Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| infection of human endothelium in vitro by cytomegalovirus causes enhanced expression of purinergic receptors: a potential virus escape mechanism? | human cytomegalovirus (cmv) uses different strategies to escape from human host defense reactions. previously we have observed that infection of endothelial cells with cmv in vitro leads to enhanced activity of endothelial ectonucleotidases. these ectoenzymes are responsible for hydrolysis of extracellular adenine nucleotides, resulting in the formation of adenosine. infection with cmv in vivo therefore may result in local increase of adenosine production, providing an anti-inflammatory and anti ... | 2007 | 18049120 |
| possible roles of transcription factors of pseudorabies virus in neuropathogenicity. | pseudorabies virus (prv) is also known by its taxonomic name, suid herpesvirus 1, or by its original name, aujeszky's disease virus. prv is a swine herpesvirus of the alphaherpesvirinae subfamily to which varicella-zoster virus (vzv) and herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) belong. prv is a pathogen of swine resulting in devastating disease and economic losses worldwide. it causes severe neurological disorders in infected piglets and latent infection in surviving pigs. prv also ... | 2007 | 18046989 |
| the number of herpes simplex virus-infected neurons and the number of viral genome copies per neuron correlate with the latent viral load in ganglia. | the latent viral load is the most important factor that predicts reactivation rates of animals latently infected with herpes simplex virus (hsv). to estimate the latent viral load, individual latently infected mouse trigeminal ganglia were dispersed into single cell suspensions and plated into 96-well real-time pcr plates, and hsv-2 genome copies were measured. by assuming a poisson distribution for both the number of hsv-2 infected cells per well and the number of hsv-2 genome copies per infect ... | 2008 | 18045638 |
| risk factors for herpes simplex virus type 2 and hiv among women at high risk in northwestern tanzania: preparing for an hsv-2 intervention trial. | to determine prevalence of and risk factors for herpes simplex virus type 2 (hsv-2) and hiv among women being screened for a randomized, controlled trial of hsv suppressive therapy in northwestern tanzania. | 2007 | 18043318 |
| [genital herpes and hsv transmission in hiv patients]. | there is a bidirectional relationship between hsv-2 and hiv-1, both at the cellular level, as well as regarding transmission and even progression of hiv-1 infection. there is clear evidence that anti-herpetic therapy reduces the plasma and mucosal hiv-1 viral load, as well as transmission. serologic testing for hsv-2 in patients with an increased hiv-1 risk, coupled with a better understanding of the interaction between the viruses and appropriate anti-herpetic suppression therapy could both red ... | 2008 | 18040650 |
| effect of resiquimod 0.01% gel on lesion healing and viral shedding when applied to genital herpes lesions. | resiquimod, a toll-like receptor 7/8 agonist developed as a topical treatment to decrease recurrences of anogenital herpes, induces proinflammatory cytokines that may delay lesion healing. adults with frequently recurring anogenital herpes were randomized within 24 h of onset of a recurrence to vehicle or resiquimod 0.01% gel two times per week for 3 weeks. subjects underwent daily lesion assessments and sampling for herpes simplex virus dna pcr for 21 days or until investigator-determined heali ... | 2008 | 18039918 |
| multinucleate epithelial change in colorectal hyperplastic polyps: a review of 27 cases. | to document the histological features of multinucleated epithelial giant cells (megs) in colorectal hyperplastic polyps and determine a possible aetiological agent. | 2008 | 18037663 |
| real-time pcr for type-specific identification of herpes simplex in clinical samples: evaluation of type-specific results in the context of cns diseases. | hsv-1 and hsv-2 cause cns infections of dissimilar clinico-pathological characteristics with prognostic and therapeutic implications. | 2008 | 18037340 |
| exophytic ulcerated tumors in hiv patients: diagnostic and therapeutic problems. | two hiv-positive male patients with a rarely documented form of genital herpes are described. in both cases the atypical clinical presentation suggested neoplastic rather than infectious lesions. this tumorous genital herpes may occur in hiv-infected patients while on antiretroviral therapy. since therapeutic failure to nucleoside analogues is common in these cases even in the absence of phenotypical resistance, other treatment options are discussed. | 2008 | 18032901 |
| the ul14 tegument protein of herpes simplex virus type 1 is required for efficient nuclear transport of the alpha transinducing factor vp16 and viral capsids. | the protein encoded by the ul14 gene of herpes simplex virus type 1 (hsv-1) and hsv-2 is expressed late in infection and is a minor component of the virion tegument. an ul14-deficient hsv-1 mutant (ul14d) forms small plaques and exhibits an extended growth cycle at low multiplicities of infection (moi) compared to wild-type virus. although ul14 is likely to be involved in the process of viral maturation and egress, its precise role in viral replication is still enigmatic. in this study, we found ... | 2008 | 18032514 |
| [is antiviral therapy indicated in patients with rheumatological diseases?]. | there is recently being observed increase of the specific weight of the opportunistic bacterial-and-viral infections, the initial onset or reactivation of which are associated with the immunity suppression, e.g. due to immunosuppressive therapy. viral infection in cases with rheumatic diseases often leads to severe process of the main disease and development of serious complications, such as hepatitis, nephritis, pneumonia and others. this is especially actual at the early stages of the disease ... | 2006 | 18030787 |
| development of a multiplex polymerase chain reaction for detection and typing of major human herpesviruses in cerebrospinal fluid. | infections of the central nervous system (cns) represent a difficult diagnostic problem for both clinicians and microbiologists. in particular, the herpesviridae family plays a central etiological role in cns viral infections. these diseases have acquired growing importance in the past few years owing to the increasing number of immunocompromised patients and the availability of new antiviral drugs. prompt detection and diagnosis of cns viral infections are critical because most infections are t ... | 2007 | 18026203 |
| herpesvirus vaccines: an update. | the development of vaccines against the herpesviruses has major public health importance because of the wide spectrum of associated clinical disease with this virus in both immunocompetent and immunocompromised populations. because these viruses establish latent infections capable of subsequent reactivation, both immunotherapeutic and prophylactic vaccine strategies are needed. a range of vaccine formulations has been devised, largely as a result of the rapid growth in knowledge in molecular mic ... | 1998 | 18020599 |
| [meningoradiculitis caused by herpes simplex virus type 2]. | a 24-year-old immune-competent woman was admitted to hospital with a three-day history of fever and headache. on examination bilateral facial nerve palsy, lumbosacral radicular pain, reduced sacral sensibility and urinary retention were found. open perianal lesions were suspect for genital herpes. the symptoms were compatible with a meningoradiculitis including a sacral polyradiculitis. on testing, cerebrospinal fluid was found to be abnormal with a lymphocytic cell reaction. polymerase chain re ... | 2007 | 18019219 |
| prevalent herpes simplex virus type 2 infection is associated with altered vaginal flora and an increased susceptibility to multiple sexually transmitted infections. | prevalent herpes simplex virus type 2 (hsv-2) infection increases human immunodeficiency virus acquisition. we hypothesized that hsv-2 infection might also predispose individuals to acquire other common sexually transmitted infections (stis). | 2007 | 18008255 |
| effect of genital ulcer disease on hiv-1 coreceptor expression in the female genital tract. | to examine the expression of human immunodeficiency virus type 1 (hiv-1) coreceptors (ccr5 and cxcr4) by monocytic cells within human genital ulcers. | 2007 | 18008231 |
| herpes simplex virus (hsv) suppression with valacyclovir reduces rectal and blood plasma hiv-1 levels in hiv-1/hsv-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial. | herpes simplex virus type 2 (hsv-2) infection is common among human immunodeficiency virus (hiv)-infected persons, and hsv reactivation increases plasma and genital hiv-1 levels. we studied hiv-1 levels during hsv suppression in coinfected persons in a placebo-controlled crossover trial. | 2007 | 18008230 |
| disruption of the u(l)41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes. | the herpes simplex virus 2 dl5-29 replication-defective mutant virus has been shown to induce protective immunity in mice and both prophylactic and therapeutic immunity in guinea pigs. in an attempt to improve the efficacy of dl5-29 we disrupted its u(l)41 gene, producing the triple mutant virus dl5-29-41l. dl5-29-41l has a decreased ability to inhibit host cell protein synthesis and a reduced cytopathic effect on cultured cells. when used to immunize mice, dl5-29-41l elicited significantly stro ... | 2008 | 18006033 |
| alternative entry receptors for herpes simplex virus and their roles in disease. | either herpesvirus entry mediator (hvem, tnfrsf14) or nectin-1 (pvrl1) is sufficient for herpes simplex virus (hsv) infection of cultured cells. the contribution of individual receptors to infection in vivo and to disease is less clear. to assess this, tnfrsf14(-/-) and/or pvrl1(-/-) mice were challenged intravaginally with hsv-2. infection of the vaginal epithelium occurred in the absence of either hvem or nectin-1 but was virtually undetectable when both receptors were absent, indicating that ... | 2007 | 18005714 |
| seroprevalence of herpes simplex virus type 2 infection in russia. | 2007 | 18005521 | |
| human immunodeficiency virus-1 infection correlates strongly with herpes simplex virus-2 (genital herpes) seropositivity in south african and united states blood donations. | in south africa, human immunodeficiency virus-1 (hiv-1) infection correlates with herpes simplex virus-2 (hsv-2; genital herpes) seropositivity in genitourinary disease clinic attendees. hsv-2 infection may be a marker for risk behavior and/or directly facilitate hiv-1 transmission. the rate of hsv-2 infection in hiv-infected south african and us blood donations was assessed, and whether the infections were correlated in donors screened and found negative for high-risk behavior by predonation in ... | 2008 | 18005322 |
| rapid, sensitive, and specific lateral-flow immunochromatographic point-of-care device for detection of herpes simplex virus type 2-specific immunoglobulin g antibodies in serum and whole blood. | herpes simplex virus type 2 (hsv-2) is a common human pathogen that can cause a variety of clinical manifestations in humans. in order to provide near-patient results to allow for faster counseling and treatment, a rapid point-of-care test that is accurate and simple to use is desirable. here, we describe the development and evaluation of an hsv-2 immunoglobulin g (igg)-specific antibody lateral-flow immunochromatographic assay (lfia) based on colloidal gold nanoparticles. a total of 359 serum s ... | 2008 | 18003814 |
| the effect of highly active antiretroviral therapy on outcome of central nervous system herpesviruses infection in cuban human immunodeficiency virus-infected individuals. | with the rapid progress in the development of highly active antiretroviral therapy (haart), the observed patterns in human immunodeficiency virus (hiv) encephalitis has changed, allowing herpesvirus (hv) infection to be controlled. haart was first administered to hiv patients in cuba in 2001. consequently with the aim of investigate the behavior of the hvs causing neurological disorders in this population in the post-haart era, the authors perform a clinical evaluation by a multiplex nested poly ... | 2007 | 17994429 |
| a delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology. | the etiology of bacterial vaginosis (bv) is poorly understood, but better definition of the risk factors associated with its acquisition should improve our understanding of this complex disease entity. | 2008 | 17989585 |
| discrimination of antibody to herpes b virus from antibody to herpes simplex virus types 1 and 2 in human and macaque sera. | the antigenic cross-reactive characteristics of herpes b virus and herpes simplex virus (hsv) type 1 (hsv-1) and hsv-2 are responsible for false-positive diagnoses by serological assays in humans and macaques. in the present study, we developed a fluorometric indirect enzyme-linked immunosorbent assay (elisa) with recombinant herpes b virus glycoprotein d (gd) and hsv-1 and hsv-2 gg (gg-1 and gg-2, respectively) to discriminate between the three primate herpesvirus infections. the secreted form ... | 2008 | 17989200 |
| herpes simplex virus type 2 encephalitis in an elderly immunocompetent male. | an 85-year-old immunocompetent man was hospitalized following the development of increasing confusion and intermittent disorientation over a 48-hour period. within 48 hours of hospitalization, he was oriented to person only and was unable to follow commands. there were no focal neurologic deficits. magnetic resonance imaging of the brain showed extensive perivascular demyelination. lumbar puncture was performed and showed normal opening pressure. cerebrospinal fluid analysis showed 8 leukocytes ... | 2007 | 17984749 |
| maternal exposure to herpes simplex virus and risk of psychosis among adult offspring. | viral exposure during gestation is thought to be a risk factor for schizophrenia. previous studies have indicated that prenatal exposure to herpes simplex virus type 2 (hsv-2) may be a risk for the subsequent development of schizophrenia in some populations. in this investigation, we tested a large and diverse population to assess the risk of psychoses among offspring of mothers with serological evidence of hsv-2 infection. | 2008 | 17981263 |
| inhibitory effect of essential oils against herpes simplex virus type 2. | essential oils from anise, hyssop, thyme, ginger, camomile and sandalwood were screened for their inhibitory effect against herpes simplex virus type 2 (hsv-2) in vitro on rc-37 cells using a plaque reduction assay. genital herpes is a chronic, persistent infection spreading efficiently and silently as sexually transmitted disease through the population. antiviral agents currently applied for the treatment of herpesvirus infections include acyclovir and its derivatives. the inhibitory concentrat ... | 2008 | 17976968 |
| intrahepatic cholestasis occurring with prurigo of pregnancy. | a 23-year-old woman presented to our polyclinic complaining of itching, generalized dermatitis, and jaundice. she was in her 31st gestational week and had developed pruritus and the dermatitis since the first month of pregnancy; her jaundice started about a month before presentation. her history included similar complaints in a previous pregnancy, which resulted in premature birth of a baby with a permanent brain defect. one of her sisters had had jaundice and itching in her 27th gestational wee ... | 2007 | 17975352 |
| 2-phenylimidazopyridines, a new series of golgi compounds with potent antiviral activity. | drugs targeted to viral proteins are highly vulnerable to the development of resistant strains. we previously characterized a group of 2-phenylbenzimidazole compounds for their activity against allergy and asthma and more recently established the golgi as their probable site of action. herein we describe their activity against the propagation of several virus types through an action on the host cell. the most potent derivatives are the novel 2-phenylimidazopyridines, the lead compound of which i ... | 2007 | 17973358 |
| sentinel surveillance of sexually transmitted infections/hiv and risk behaviors in vulnerable populations in 5 central american countries. | in el salvador, guatemala, honduras, nicaragua, and panama, we recruited 2466 female sex workers (fsws) by probabilistic or comprehensive sampling and 1418 men who have sex with men (msm) by convenience sampling to measure sociobehavioral risk and sexually transmitted infections. for msm, hiv seroprevalence ranged from 7.6% in nicaragua to 15.3% in el salvador, and estimated hiv seroincidence per 100 person-years ranged from 2.7 in panama to 14.4 in nicaragua; 61% reported using condoms consiste ... | 2007 | 17972366 |
| a 9 year-old girl with herpes simplex virus type 2 acute retinal necrosis treated with intravitreal foscarnet. | a 9-year-old girl presented with a 2-week history of redness in the left eye. examination revealed vitritis, retinal whitening, vasculitis, and optic nerve head edema. polymerase chain reaction testing of the aqueous fluid revealed herpes simplex virus type 2. the retinitis was controlled with intravenous acyclovir and intravitreal foscarnet. the clinical course was complicated by retinal neovascularization and vitreous hemorrhage, which was treated by pars plana vitrectomy and endolaser. while ... | 2007 | 17972224 |
| high-risk sexual behaviour in men attending a sexually transmitted infection clinic in durban, south africa. | a study of men with genital ulcer disease (gud) in durban, south africa, at the start of the local hiv epidemic in 1988/1989 found that 36% of men with gud continued with sexual intercourse despite symptoms. the aim of this study was to determine whether this high-risk behaviour was still prevalent and to enquire about similar risk behaviours with other sexually transmitted infection (sti)-related problems. | 2007 | 17971375 |
| [development of multiplex real-time pcr assay for the detection of herpes simplex virus types 1 and 2]. | we developed a multiplex real-time pcr assay to simultaneously detect herpes simplex virus-1 (hsv-1) and hsv-2 genomes. taqman pcr primer pairs and fluologenic probes targeting the hsv-1 or hsv-2 gpd region were originally designed. the detection limit was 15 copies/tube, and the quantitative range was from 15 to 1.5 x 10(6) copies/tube of hsv-1 or hsv-2 dna. the sensitivity of this assay was 10(3) times higher than the conventional pcr assay. no other herpes virus dna-cytomegalovirus, epstein-b ... | 2007 | 17966636 |
| evaluation of a theta-defensin in a murine model of herpes simplex virus type 1 keratitis. | to test the activity of a synthetic theta-defensin, retrocyclin (rc)-2, in a murine herpes simplex virus (hsv)-1 keratitis model. | 2007 | 17962464 |
| [epidemiologic study on std/hiv infections among tin mining workers in gejiu, yunnan province]. | to estimate human immunodeficiency virus (hiv)/sexually transmitted diseases (stds) related knowledge, the prevalence and risk factors for hiv/stds among tin miners in gejiu, yunnan province. | 2007 | 17959049 |
| epidemiology of orofacial herpes simplex virus infections in the general population in france: results of the herpimax study. | prevalence of clinically manifest orofacial herpes in the general population is poorly characterized. objectives to establish the lifetime prevalence of clinically manifest orofacial herpes and its relationship with herpes simplex virus (hsv) serotype in the french general population. | 2007 | 17958848 |
| hiv-1/hsv-2 co-infected adults in early hiv-1 infection have elevated cd4+ t cell counts. | hiv-1 is often acquired in the presence of pre-existing co-infections, such as herpes simplex virus 2 (hsv-2). we examined the impact of hsv-2 status at the time of hiv-1 acquisition for its impact on subsequent clinical course, and total cd4+ t cell phenotypes. | 2007 | 17957262 |
| atypical herpes simplex infection masquerading as recalcitrant pemphigus vulgaris. | a 57-year-old woman presented with refractory genital erosive disease. one year earlier she experienced gingival fragility; direct immunofluorescence resulted in the diagnosis of cicatricial pemphigoid, and prednisone therapy led to initial improvement. initial skin biopsy of her genital erosions demonstrated full-thickness ulceration with viral cytopathic change and a re-epithelializing subepidermal separation. indirect immunofluorescence revealed intercellular igg staining on monkey oesophagus ... | 2007 | 17956485 |
| antibody-mediated protection against genital herpes simplex virus type 2 disease in mice by fc gamma receptor-dependent and -independent mechanisms. | the ability of antibody (ab) to modulate hsv pathogenesis is well recognized but the mechanisms by which hsv-specific igg antibodies protect against genital hsv-2 disease are not well understood. the requirement for ab interactions with fcgamma receptors (fcgammar) in protection was examined using a murine model of genital hsv-2 infection. igg antibodies isolated from the serum of hsv-immune mice protected normal mice against hsv-2 disease when administered prior to genital hsv-2 inoculation. ho ... | 2008 | 17950908 |
| a monocyte-specific peptide from herpes simplex virus type 2 glycoprotein g activates the nadph-oxidase but not chemotaxis through a g-protein-coupled receptor distinct from the members of the formyl peptide receptor family. | we have recently identified a peptide derived from the secreted portion of the hsv-2 glycoprotein g, gg-2p20, to be proinflammatory. based on its ability to activate neutrophils and monocytes via the formyl peptide receptor (fpr) to produce reactive oxygen species (ros) that down-regulate nk cell function, we suggested it to be of importance in hsv-2 pathogenesis. we now describe the effects of an overlapping peptide, gg-2p19, derived from the same hsv-2 protein. also, this peptide activated the ... | 2007 | 17947682 |
| importance of myeloid differentiation factor 88 in innate and acquired immune protection against genital herpes infection in mice. | toll-like receptors (tlrs) play an important role as pattern-recognition receptors to sense and respond to pathogens. our laboratory and others have shown recently that activation of tlr/myd88 signaling through vaginal administration of cpg oligodeoxynucleotides, either singly or in combination with recombinant glycoprotein from herpes simplex virus type 2 (hsv-2), confers immunity against genital herpes infection. in this study, we have investigated the importance of the myeloid differentiation ... | 2008 | 17945349 |
| the neurotropic herpes viruses: herpes simplex and varicella-zoster. | herpes simplex viruses types 1 and 2 (hsv1 and hsv2) and varicella-zoster virus (vzv) establish latent infection in dorsal root ganglia for the entire life of the host. from this reservoir they can reactivate to cause human morbidity and mortality. although the viruses vary in the clinical disorders they cause and in their molecular structure, they share several features that affect the course of infection of the human nervous system. hsv1 is the causative agent of encephalitis, corneal blindnes ... | 2007 | 17945155 |
| decline in hiv prevalence among women of childbearing age in moshi urban, tanzania. | the objective of this study was to describe trends over time in hiv prevalence, sexually transmitted infections (stis) and sexual behaviour among women in moshi urban, tanzania. two cross-sectional studies were conducted in 1999 and in 2002-04 among women attending three primary health-care clinics. they were interviewed and screened for hiv and stis. there was a significant decrease in hiv prevalence (11.5-6.9%). the decline was greatest among women aged 15-24 years. syphilis, trichomoniasis, b ... | 2007 | 17945046 |
| common infectious agents in multiple sclerosis: a case-control study in children. | environmental factors, in particular infections, have been linked with the risk of developing multiple sclerosis (ms). the association of epstein-barr virus infection with childhood onset of ms has been recently recognized. as other infections characteristically experienced during childhood have not yet been studied in larger cohorts of paediatric ms, we conducted a study on 152 german children with ms (age at onset <16 years) and matched controls in the hope of gaining evidence for their possib ... | 2008 | 17942525 |
| case report: herpes meningitis complicating genital herpes presenting as anal fissure. | a 33-year-old woman presented with stabbing perianal pain and intermittent headache and photophobia. examination revealed atypical multiple perianal fissures with non-specific neurological findings. polymerase chain reaction of the perianal swab and cerebrospinal fluid examination confirmed the diagnosis of perianal herpes simplex type 2 ulcer with herpes meningitis. this report emphasizes the importance of performing further investigations on patients with atypical anal fissures with or without ... | 2007 | 17939904 |
| [study on the association between vaginal douching and sexually transmitted diseases among female sex workers in a county of yunnan province]. | to explore the epidemic characteristics of vaginal douching, human immunodeficiency virus (hiv) and other sexually transmitted diseases(std) among female sex workers (fsws) in yunnan province. | 2007 | 17939384 |
| human papillomavirus infection: epidemiology and pathophysiology. | more than 120 different types of the human papillomavirus (hpv) have been isolated; >40 of these types infect the epithelial lining of the anogenital tract and other mucosal areas. in the majority of individuals, hpv infections are transient and asymptomatic with most new infections resolving within 2 years. epidemiological data from the u.s. national health and nutrition examination survey determined that the prevalence of hpv infection in a representative sample of women was highest in those a ... | 2007 | 17938014 |
| yin chen hao tang, a chinese prescription, inhibits both herpes simplex virus type-1 and type-2 infections in vitro. | yin chen hao tang (ycht) is one of the most frequently used prescriptions in the long history of traditional chinese medicine practice. the prescription contains three chinese herbs, namely artemisia capillaries thunb. (compositae), rheum officinale baillon (polygonaceae), and gardenia jasminoids ellis (rubiaceae), and has been widely used to treat acute hepatitis with jaundice. in this study, the in vitro anti-hsv-1 and hsv-2 activities of the water extract of ycht were investigated. results sh ... | 2008 | 17931713 |
| inhibition of hsv-1 replication and hsv dna polymerase by the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-d-ribofuranosyl) quinoline-3-carboxylic acid and its aglycone. | we describe in this paper that the synthetic chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-d-ribofuranosyl) quinoline-3-carboxylic acid (compound a) and its free aglycogene base (compound b) inhibit, with low cytotoxicity, the replication of herpes simplex virus type 1 and 2 (hsv-1 and hsv-2). compound a inhibited hsv-1 replication in vero cells with an ec(50) of 1.3 and 1.4 microm for an acyclovir (acv)-sensitive strain and an acv-resistant strain of this virus, respectiv ... | 2008 | 17931712 |
| rise in seroprevalence of herpes simplex virus type 1 among highly sexual active homosexual men and an increasing association between herpes simplex virus type 2 and hiv over time (1984-2003). | herpes simplex virus type 1 and type 2 (hsv-1 and hsv-2) are both highly prevalent. the rate of genital hsv-1 transmission is reportedly increasing over time. hsv-2 is considered to be an important risk factor for hiv transmission. we therefore studied changes in the hsv-1 and hsv-2 prevalence in a large cohort of men who have sex with men (msm) over a 20-year time period. | 2007 | 17929177 |
| herpes simplex virus type 2 glycoprotein g is targeted by the sulfated oligo- and polysaccharide inhibitors of virus attachment to cells. | variants of herpes simplex virus type 2 (hsv-2) generated by virus passage in gmk-ah1 cells in the presence of the sulfated oligosaccharide pi-88 were analyzed. many of these variants were substantially resistant to pi-88 in their initial infection of cells and/or their cell-to-cell spread. the major alteration detected in all variants resistant to pi-88 in the initial infection of cells was a frameshift mutation(s) in the glycoprotein g (gg) gene that resulted in the lack of protein expression. ... | 2007 | 17928351 |
| potent inhibition of genital herpesvirus infection in goats by cidofovir. | like human herpesvirus 2 (hhv-2) in humans, infection by caprine herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects of anti-herpetic drugs. | 2007 | 17926653 |
| seminal plasma reduces the effectiveness of topical polyanionic microbicides. | the objective of this study was to test the activity of microbicides against herpes simplex virus type 2 (hsv-2) introduced in seminal plasma. we found that seminal plasma interfered with the activity of pro 2000 and of cellulose sulfate, increasing by 100-fold the concentration of drug required to inhibit 90% of viral plaque formation. seminal plasma competitively inhibited binding of the microbicides to the hsv-2 envelope. most of the interference was found in a high molecular-weight fraction; ... | 2007 | 17922405 |
| does frequency of genital herpes recurrences predict risk of transmission? further analysis of the valacyclovir transmission study. | the benefit of suppressive antiviral therapy for reducing the risk of herpes simplex virus (hsv)-2 transmission to sex partners may be enhanced if persons at high risk for transmission can be identified. | 2008 | 17921912 |
| purification and identification of antiviral components from laggera pterodonta by high-speed counter-current chromatography. | although laggera pterodonta, a folk medicine has been widely used for several centuries as an antiviral agent, there have been no studies to identify its antiviral components. a bioassay-guided phytochemical examination of l. pterodonta disclosed that its aqueous extract, which was made up of three dicaffeoylquinic acids showed significant inhibitory activity of virus replication. then a simple and efficient preparative high-speed counter-current chromatography (hsccc) method was successfully es ... | 2007 | 17920342 |
| impaired antiviral activity of monocytes from patients on hemodiafiltration. | the aim of our study was to determine whether intermittent hemodiafiltration (hdf) leads to an alteration in monocyte antiviral activity as well as in the in vitro release of cytokines such as interleukin-12 (il-12), tumor necrosis factor-alpha (tnf-alpha) and interferon-alpha (ifn-alpha) by the same cells. | 2007 | 17918141 |
| immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ocular disease. | ocular infections with herpes simplex virus 1 can lead to corneal scarring and blindness, with herpes keratitis being the major infectious cause of blindness. there is currently no clinically approved vaccine and nearly all developmental vaccines are targeted against hsv-2 and genital herpes. we tested the ability of an hsv-2 replication-defective virus, a genital herpes vaccine candidate, to protect against hsv-1 corneal infection. immunization with hsv-2 dl5-29 reduced viral replication in the ... | 2007 | 17915278 |
| effect of sexually transmitted disease (std) coinfections on performance of three commercially available immunosorbent assays used for detection of herpes simplex virus type 2-specific antibody in men attending baltimore, maryland, std clinics. | two hundred seventy-nine serum samples from men attending sexually transmitted disease (std) clinics in baltimore, maryland, were tested for herpes simplex virus type 2 (hsv-2)-specific antibody by three immunosorbent glycoprotein g-2-based assays (the kalon, focus, and biokit assays). the results for all samples with positive results were confirmed by western blotting (91/279; 32.6% hsv-2 seroprevalence). all patients were also tested for chlamydia trachomatis, neisseria gonorrhoeae, trichomona ... | 2007 | 17913866 |
| type i interferon production during herpes simplex virus infection is controlled by cell-type-specific viral recognition through toll-like receptor 9, the mitochondrial antiviral signaling protein pathway, and novel recognition systems. | recognition of viruses by germ line-encoded pattern recognition receptors of the innate immune system is essential for rapid production of type i interferon (ifn) and early antiviral defense. we investigated the mechanisms of viral recognition governing production of type i ifn during herpes simplex virus (hsv) infection. we show that early production of ifn in vivo is mediated through toll-like receptor 9 (tlr9) and plasmacytoid dendritic cells, whereas the subsequent alpha/beta ifn (ifn-alpha/ ... | 2007 | 17913820 |
| risk factors of herpes simplex virus type 2 among std clinic attenders in delhi, india. | the present study was conducted to determine the seroprevalence and risk factors associated with hsv-2 infection among sexually transmitted diseases (std) clinic attenders of delhi in india. out of 128 patients included, 76 were males and 52 were females. antibodies to hsv 1 and 2 and hiv infection were determined by elisa. syphilis seropositivity was determined by vdrl test and confirm by tpha test. ulcer scrapping were stained by giemsa for herpes progenitalis and donovan bodies and grams for ... | 2006 | 17913210 |
| sexual risk factors for hiv infection in early and advanced hiv epidemics in sub-saharan africa: systematic overview of 68 epidemiological studies. | it is commonly assumed that sexual risk factors for heterosexual hiv transmission in sub-saharan africa, such as multi-partner sex, paid sex and co-infections, become less important as hiv epidemics mature and prevalence increases. | 2007 | 17912340 |
| antimicrobial activity and protective properties of vaginal lactobacilli from healthy bulgarian women. | the role of vaginal lactobacillus as an efficient barrier against invading pathogens is of considerable interest. the purpose of the present study was to assess in vitro the ability of 20 recently identified vaginal lactobacilli to protect the vagina. in order to evaluate their significance, the antimicrobial, hemagglutination (ha) and aggregation (agg) activities, as well as acid and hydrogen peroxide (h(2)o(2)) production, were estimated. the cell-free cultures of eight strains showed a stable ... | 2007 | 17910924 |
| systemic therapy of spontaneous prostate cancer in transgenic mice with oncolytic herpes simplex viruses. | oncolytic viruses are an innovative therapeutic strategy for cancer, wherein viral replication and cytotoxicity are selective for tumor cells. here we show the efficacy of systemically administered oncolytic viruses for the treatment of spontaneously arising tumors, specifically the use of oncolytic herpes simplex viruses (hsv) administered i.v. to treat spontaneously developing primary and metastatic prostate cancer in the transgenic tramp mouse, which recapitulates human prostate cancer progre ... | 2007 | 17909046 |
| a regulatory role of interleukin 15 in wound healing and mucosal infection in mice. | il-15 plays a critical role in the development and maturation of gammadelta intraepithelial t lymphocytes (iel), which are known to play important roles in wound healing and resolving inflammation in mice. in this study, we found that il-15 transgenic (tg) mice, under the control of a mhc class i promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with hsv-2. the iel in the skin and reproductive organs of il-15 tg mice produced an aberrantly higher leve ... | 2008 | 17906118 |
| aciclovir resistance among indian strains of herpes simplex virus as determined using a dye uptake assay. | resistance to aciclovir (acv) among herpes simplex virus (hsv) isolates is increasingly being reported in the literature particularly in immunocompromised patients. however, there is only limited data available from india despite widespread use of acv in our hospital. a cross-sectional study was hence conducted to determine the aciclovir (acv) susceptibility of hsv 1 and 2 isolates using a dye uptake (du) assay. this study showed a 3.0% prevalence of acv resistance among hsv-1 strains (2/66, med ... | 2007 | 17901647 |
| predictors of incident herpes simplex virus type 2 infections in young women at risk for unintended pregnancy in san francisco. | young women receiving family planning services are at risk for both unintended pregnancy and herpes simplex virus type 2 (hsv-2) infection. | 2007 | 17897466 |
| antiherpevirus activity of artemisia arborescens essential oil and inhibition of lateral diffusion in vero cells. | new prophylactic and therapeutic tools are needed for the treatment of herpes simplex virus infections. several essential oils have shown to possess antiviral activity in vitro against a wide spectrum of viruses. | 2007 | 17894898 |
| growth-compromised hsv-2 vector delta rr protects from n-methyl-d-aspartate-induced neuronal degeneration through redundant activation of the mek/erk and pi3-k/akt survival pathways, either one of which overrides apoptotic cascades. | we have previously shown that intrastriatal injection of delta rr, the growth-compromised herpes simplex virus type 2 (hsv-2) vector for the antiapoptotic protein icp10pk, prevents apoptosis caused by the excitotoxin n-methyl-d-aspartate (nmda) in a mouse model of glutamatergic neuronal cell death (golembewski et al. [2007] exp. neurol. 203:381-393). because apoptosis regulation is stimulus and cell type specific, our studies were designed to examine the mechanism of delta rr-mediated neuroprote ... | 2008 | 17893911 |
| childhood weber-christian disease: clinical investigation and virus detection. | to investigate clinical features of childhood weber-christian disease (wcd) and the relationship between wcd and virus. | 2007 | 17888054 |
| fold recognition insights into function of herpes icp4 protein. | icp4 is an important factor regulating the life cycle of hsv1. this conserved protein has several molecular functions, including activation of expression of viral late gene transcripts and inhibition of immediate early genes. although icp4 and its alphaherpesvirinae homologs (eg.: ie62 of vzv) have been subjects of various molecular studies, a complete view of their molecular function is lacking. here we present the results of fold recognition and molecular modelling of icp4 functional domains. ... | 2007 | 17882324 |
| effectiveness and efficiency of imperfect therapeutic hsv-2 vaccines. | efforts are currently underway to develop therapeutic vaccines for herpes simplex virus type 2 (hsv-2). | 2007 | 17881889 |
| susceptibility of human female primary genital epithelial cells to herpes simplex virus, type-2 and the effect of tlr3 ligand and sex hormones on infection. | genital epithelial cells (ecs) are the first line of defense that sexually transmitted viruses encounter. the mechanism of viral pathogenesis in these cells is not well understood. here, we show that a primary cell culture model from human reproductive tract tissues can be used as a novel ex vivo model in examining the interaction of herpes simplex virus, type 2 (hsv-2), with female genital mucosa. confluent, polarized primary cultures of human endometrial and cervical ecs were established and s ... | 2007 | 17881767 |
| divergence and recombination of clinical herpes simplex virus type 2 isolates. | herpes simplex virus type 2 (hsv-2) infects the genital mucosa and is one of the most common sexually transmitted viruses. here we sequenced a segment comprising 3.5% of the hsv-2 genome, including genes coding for glycoproteins g, i, and e, from 27 clinical isolates from tanzania, 10 isolates from norway, and 10 isolates from sweden. the sequence variation was low compared to that described for clinical hsv-1 isolates, with an overall similarity of 99.6% between the two most distant hsv-2 isola ... | 2007 | 17881457 |
| an update on short-course episodic and prevention therapies for herpes genitalis. | the prevalence of herpes genitalis (genital herpes) has increased markedly over the past three decades. the most common cause is infection with the herpes simplex virus type 2 (hsv-2), but it can also occur as a result of hsv-1 infection. herpes genitalis can cause substantial psychosexual as well as physical morbidity and, in immunocompromised individuals, such as those who are hiv-positive, hsv infection can result in severe disease with progressive and extensive lesions. the natural history o ... | 2007 | 17877886 |
| recommendations for short-course therapies in herpes genitalis and herpes labialis. | 2007 | 17877885 | |
| the herpes simplex virus type 2 gene icp10pk protects from apoptosis caused by nerve growth factor deprivation through inhibition of caspase-3 activation and xiap up-regulation. | the herpes simplex virus type 2 (hsv-2) protein icp10pk has anti-apoptotic activity in virus-infected hippocampal cultures through activation of the ras/raf-1/mek/erk pathway. to exclude the possible contribution of other viral proteins to cell fate determination, we examined the survival of primary hippocampal cultures and neuronally differentiated pc12 cells transfected with icp10pk from apoptosis caused by nerve growth factor (ngf) withdrawal. ngf deprivation caused apoptosis in cultures mock ... | 2007 | 17877640 |
| viral infections and lower urinary tract symptoms in the third national health and nutrition examination survey. | previous epidemiological studies described suggestive positive associations between sexually transmitted infections, particularly gonorrhea and human immunodeficiency virus infection, and lower urinary tract symptoms. to our knowledge no groups have investigated other infections, such as human papillomavirus type 16, herpes simplex virus type 2, cytomegalovirus, human herpesvirus type 8, herpes simplex type 1, and hepatitis b and c virus infection, in relation to lower urinary tract symptoms. th ... | 2007 | 17870113 |
| herpes simplex virus type 2 infection among young uncircumcised men in kisumu, kenya. | to identify factors associated with herpes simplex virus type 2 (hsv-2) infection among men aged 18-24 in kisumu, kenya. | 2008 | 17855489 |
| genital herpes due to acyclovir-sensitive herpes simplex virus caused secondary and recurrent herpetic whitlows due to thymidine kinase-deficient/temperature-sensitive virus. | herpes simplex virus (hsv)-2 caused a genital ulcer in a 40-year-old allogenic stem cell recipient, and a secondary herpetic whitlow appeared during 2 months of acyclovir (acv) therapy. both genital ulcer, and whitlow were cured 3 months later, but 6 months after recovery the whitlow alone recurred. dna of the genital, first, and recurrent whitlow isolates showed similar endonuclease digestion fragment profiles. the genital virus was acv-sensitive, and the two whitlow isolates were acv-resistant ... | 2007 | 17854045 |
| herpes simplex virus type 2 infections of the central nervous system: a retrospective study of 49 patients. | herpes simplex virus type 2 (hsv-2) infections of the central nervous system (cns) are rare with meningitis as the most common clinical presentation. we have investigated the clinical spectrum of cns infections in 49 adult consecutive patients with hsv-2 genome in the cerebrospinal fluid (csf). hsv-2 in the csf was determined by polymerase chain reaction (pcr), and patients were diagnosed as encephalitis or meningitis according to predefined clinical criteria by retrospective data information fr ... | 2008 | 17852910 |
| herpes simplex virus type 2 among mexican high school adolescents: prevalence and association with community characteristics. | we undertook this study to estimate the prevalence and correlates of herpes simplex virus type 2 (hsv-2) among mexican adolescents in high school. | 2007 | 17845898 |
| b7 costimulation molecules expressed from the herpes simplex virus 2 genome rescue immune induction in b7-deficient mice. | the interaction between b7 costimulation molecules on antigen-presenting cells and cd28 on antigen-responsive t cells is essential for t-cell activation and maturation of immune responses to herpes simplex virus (hsv) infection. vaccine-induced immune responses also depend upon adequate upregulation of b7 costimulation molecules, but this signal may be limiting for replication-defective virus vaccines. we investigated whether expression of b7 costimulation molecules by a prototypical replication ... | 2007 | 17804511 |
| investigation of hsv-1, hsv-2, cmv, hhv-6 and hhv-8 dna by real-time pcr in surgical resection materials of epilepsy patients with mesial temporal lobe sclerosis. | the objective of this study is to investigate the presence of viral dnas of hsv-1, hsv-2, hhv-6, hhv-8, and cmv in hippocampus of the patients with mesial temporal lobe epilepsy (mtle) syndrome. | 2008 | 17804017 |
| unexpected high prevalence of herpes simplex virus (hsv) type 2 seropositivity and hsv genital shedding in pregnant women living in an east paris suburban area. | both herpes simplex virus type 2 (hsv-2) seroprevalence and the proportion of hsv-1 genital ulcers are increasing in industrialized countries. the consequences of these epidemiological changes, in pregnant women in france, for both the genital shedding of hsv and vertical transmission, have been poorly evaluated. the hsv-1 and hsv-2 seroprevalence and the rate of subclinical genital shedding of herpes close to delivery were evaluated in pregnant women, with no history of genital herpes, living i ... | 2007 | 17785000 |
| relative prevalence of different sexually transmitted infections in hiv-discordant sexual partnerships: data from a risk network study in a high-risk new york neighbourhood. | to determine infection patterns of sexually transmitted infections that facilitate hiv transmission among hiv-discordant couples. | 2008 | 17728340 |
| [asymptomatic genital herpes infection and infertility in males]. | incidence of herpes simplex virus (hsv) was studied in ejaculates of 100 men. the examinees had neither history nor clinical symptoms of hsv genital infection. hsv was detected by a rapid cultural method in the ejaculate of 20 out of 100 examinees (20%). of 67 males with infertility hsv was detected in 25%, in 19 males examined prophylactically and 14 patients with varicocele (a comparison group) it was found in 10.5 and 7% cases, respectively. oligozoospermia was two times more frequent in hsv- ... | 2007 | 17722620 |
| biological and behavioural impact of an adolescent sexual health intervention in tanzania: a community-randomized trial. | the impact of a multicomponent intervention programme on the sexual health of adolescents was assessed in rural tanzania. | 2007 | 17721102 |
| unlabeled probes for the detection and typing of herpes simplex virus. | unlabeled probe detection with a double-stranded dna (dsdna) binding dye is one method to detect and confirm target amplification after pcr. unlabeled probes and amplicon melting have been used to detect small deletions and single-nucleotide polymorphisms in assays where template is in abundance. unlabeled probes have not been applied to low-level target detection, however. | 2007 | 17720894 |
| microbicides development program, tanzania-baseline characteristics of an occupational cohort and reattendance at 3 months. | to determine baseline characteristics of an occupational cohort of women in mwanza city, tanzania, and factors associated with reattendance at 3 months, in preparation for a microbicide trial. | 2007 | 17717482 |
| successful liver transplantation in a kidney and pancreas allograft recipient with fulminant herpes simplex virus type 2 hepatitis. | 2007 | 17717028 | |
| asymptomatic shedding of herpes simplex virus (hsv) in the oral cavity. | the aim of this study was to investigate the rate of herpes simplex virus (hsv) shedding from the oral cavity, because recent studies suggest that shedding is more frequent than originally reported. factors that could influence the rate and duration of shedding from the oral cavity were examined. | 2008 | 17703961 |
| human herpesvirus-8 infection and oral shedding in amerindian and non-amerindian populations in the brazilian amazon region. | human herpesvirus type 8 (hhv-8) is hyperendemic in amerindian populations, but its modes of transmission are unknown. | 2007 | 17703414 |
| coadministration of a herpes simplex virus-2 based oncolytic virus and cyclophosphamide produces a synergistic antitumor effect and enhances tumor-specific immune responses. | despite their unique property of selective replication and propagation in tumor tissues, oncolytic viruses have had only limited antitumor effects in cancer patients. one of the major reasons is probably the host's immune defense mechanisms, which can restrict the ability of the virus to replicate and spread within tumors. the innate immune system, which can be rapidly activated during virus infection, likely plays a more pivotal antiviral role than does acquired immunity, as the antitumor effec ... | 2007 | 17699791 |
| prevalence of viral and mycobacterial co-infections in perinatally hiv-infected children. | the progression of hiv disease may be affected by co-infection with other viruses. this study investigates the prevalence of epstein-barr virus (ebv); cytomegalovirus (cmv); herpes simplex virus (hsv) types 1 and 2; hepatitis a, b, and c (ha, hb, hc); and tuberculosis in perinatally hiv-infected children. electrochemiluminescence immunoassay (eia) against ebv, cmv, hsv 1 and 2, hav hbv hcv, and skin testing with purified protein derivative was performed on 45 perinatally hiv-infected children. c ... | 2006 | 17696043 |
| herpes simplex virus protein ul11 but not ul51 is associated with lipid rafts. | the ul11 and ul51 gene products of herpes simplex virus (hsv) are membrane-associated tegument proteins that are incorporated into the hsv virion. ul11 and ul51 are conserved throughout the herpesvirus family. both ul11 and ul51, either singly or in combination, are involved in virion envelopment and/or egress. both proteins are fatty acylated: ul11 is both acylated by myristoic and palmitoic acids and ul51 is monoacylated by palmitoic acid. using confocal microscopy and sucrose gradient fractio ... | 2007 | 17694428 |
| hormonal contraceptive use, herpes simplex virus infection, and risk of hiv-1 acquisition among kenyan women. | studies of the effect of hormonal contraceptive use on the risk of hiv-1 acquisition have generated conflicting results. a recent study from uganda and zimbabwe found that women using hormonal contraception were at increased risk for hiv-1 if they were seronegative for herpes simplex virus type 2 (hsv-2), but not if they were hsv-2 seropositive. | 2007 | 17690576 |
| microglial glt-1 is upregulated in response to herpes simplex virus infection to provide an antiviral defence via glutathione. | herpes simplex virus (hsv) can enter the central nervous system and cause encephalitis (hsv-1) or meningitis (hsv-2). microglia, the immunocompetent cells of the central nervous system, are potentially able to detect viral infections. microglia have been shown to express the glutamate transporter glt-1 during pathological events, leading to increased microglial glutamate uptake and glutathione synthesis. this study aims to address the role of glt-1 and glutathione, a major antioxidant with antiv ... | 2007 | 17680651 |
| herpetic whitlow. | herpetic whitlow is a painful cutaneous infection that most commonly affects the distal phalanx of the fingers and occasionally the toes. it is caused by herpes simplex virus (hsv) types 1 or 2. herpetic whitlow has been known mainly for infecting healthcare workers in contact with infected secretions or mucous membranes, but the implementation of universal precautions has resulted in a decrease in the incidence of occupation-related cases. herpetic whitlow occurs mainly in adults aged 20 to 30 ... | 2007 | 17674583 |
| brainstem involvement in neonatal herpes simplex virus type 2 encephalitis. | herpes simplex virus encephalitis in the newborn typically involves the cerebral cortex in a widespread manner. herpes simplex virus type 2 rarely involves the brainstem. here we report a 16-day-old infant with predominant brainstem and cerebellar involvement secondary to herpes simplex virus type 2 infection. diffusion-weighted mri performed 3 days after the onset of symptoms revealed restricted diffusion mainly in brainstem and cerebellar structures. no abnormal findings were seen on conventio ... | 2007 | 17671049 |