Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| influenza surveillance in the islamic republic of iran from 1991 to 2001. | to better understand the annual distribution of influenza virus in our country, we isolated and typed 45 viruses from 1043 patients with acute respiratory illnesses in a 10-year study conducted by the national influenza centre of the islamic republic of iran. the seasonal distribution of influenza typically ran from november to april. type a influenza was most common during the winters of 1991-92, 1997-98 and 2000-01 and type b influenza was most common during 1992-5 and 1996-97. both type a and ... | 2004 | 16212207 |
| [sensitivity of various influenza virus strains to arbidol. influence of arbidol combination with different antiviral drugs on reproduction of influenza virus a]. | to study antiviral activity of arbidol in relation to various antigenic subtypes of influenza virus isolated from humans; efficacy of arbidol action in combination with adamantanic antiviral drugs, ribavirin and ribamidil on reproduction of influenza virus a (iva) in cell culture. | 2005 | 16206613 |
| [influenza activity 2000/2001]. | influenza viral infections are an important cause of morbidity in all age groups and are associated with a high mortality rate amongst the elderly and in risk groups. the current study analyses data from the epidemiological surveillance of influenza during the 2000/2001-winter season. clinical, epidemiological and virological data relative to cases of influenza syndrome were collected via the national influenza surveillance scheme, in collaboration with the general directory of health and integr ... | 2005 | 16202331 |
| bereavement and marriage are associated with antibody response to influenza vaccination in the elderly. | stressful life events exposure including bereavement, an event commonly experienced by elderly people, social support, marital status, and satisfaction were examined in relation to antibody response to the annual trivalent influenza vaccination in an elderly community sample (n=184). antibody response was assessed at baseline, and at 1 and 12 months following vaccination. taking into account baseline antibody titer, overall life events exposure and social support were not associated with respons ... | 2006 | 16198083 |
| [influenza in poland in 2003]. | following two years of low influenza incidence in poland, the activity of this disease markedly increased in 2003. in total 1,216,285 cases of influenza like illness were registered (incidence 3,184.4 per 100,000). regionally the incidence ranged from 1,195.7 in zachodniopomorskie to 5,719.7 per 100,000 in mazowieckie. children and adolescents under 15 years of age accounted for 41.7% of all cases (507,102 cases, age specific incidence 7,579.0 per 100,000). in this age group the incidence varied ... | 2005 | 16190524 |
| [consecutive infection by influenza viruses type a and b in the same influenza season]. | 2005 | 16185642 | |
| influenza vaccines. | 2005 | 16171031 | |
| update: influenza activity--united states and worldwide, may 22-september 3, 2005, and 2005-06 season vaccination recommendations. | influenza a (h3n2) viruses circulated worldwide, and influenza a (h1) and b viruses were reported less frequently during may 22-september 3, 2005. in north america, isolates of influenza a (h3n2), a (h1), and influenza b were identified sporadically. this report summarizes influenza activity in the united states and worldwide since the last mmwr update. | 2005 | 16163816 |
| [clinical features of respiratory infections due to influenza virus in hospitalized children]. | infants and toddlers have the highest influenza hospitalization rate in pediatrics. although the impact of this virus in children has been recognized, there is no defined statement related to vaccination in this population. | 2005 | 16163429 |
| [prevention of community-acquired pneumonia in adults]. | polysaccharide 23 valent pneumococcal vaccine commercially available from 1983 includes 23 serotypes of streptococcus pneumoniae, representing near 90% of strains involved in invasive pneumococcal disease in immune competent adults. vaccine confers protection against invasive pneumococcal disease. immunization is recommended in adults over 65 years old, in patients affected by chronic diseases (cardiopathies, copd, nephropathies, diabetes mellitus, hepatic cirrhosis, chronic breakage in brain-bl ... | 2005 | 16163421 |
| comparison of the bd directigen flu a+b kit and the abbott testpack rsv with a multiplex rt-pcr elisa for rapid detection of influenza viruses and respiratory syncytial virus. | the directigen flu a+b enzyme immunoassay and the abbott testpack rsv enzyme immunoassay were each compared with a multiplex rt-pcr elisa by testing 635 nasopharyngeal aspirates collected from children aged < 16 years who had been hospitalised with acute respiratory tract infection during the epidemic season 2002-2003. in this study, the sensitivity of the directigen flu a+b assay was unacceptably low (29.3% and 10.0%, respectively) for the detection of influenza a and b viruses. the sensitivity ... | 2005 | 16153263 |
| influenza immunisation in children with solid tumours. | we assessed response to immunisation with trivalent split virus influenza vaccine in children with non-leukaemic malignant disease. children with solid tumours and lymphoma received one or two doses of influenza vaccine, according to current uk guidelines, in autumn 2001 and/or 2002. children were currently receiving chemotherapy or were within 6 months of completing chemotherapy. pre and post vaccination sera were assessed for antibodies to the prevalent influenza strains by haemagglutination i ... | 2005 | 16143516 |
| antiviral effect of catechins in green tea on influenza virus. | polyphenolic compound catechins ((-)-epigallocatechin gallate (egcg), (-)-epicatechin gallate (ecg) and (-)-epigallocatechin (egc)) from green tea were evaluated for their ability to inhibit influenza virus replication in cell culture and for potentially direct virucidal effect. among the test compounds, the egcg and ecg were found to be potent inhibitors of influenza virus replication in mdck cell culture and this effect was observed in all influenza virus subtypes tested, including a/h1n1, a/h ... | 2005 | 16137775 |
| sensitivity of influenza viruses to zanamivir and oseltamivir: a study performed on viruses circulating in france prior to the introduction of neuraminidase inhibitors in clinical practice. | influenza virus neuraminidase inhibitors (nais) were introduced in clinical practice in various parts of the world since 1999 but were only scarcely distributed in france. prior to the generalization of zanamivir and oseltamivir utilization in our country, we decided to test a large panel of influenza strains to establish the baseline sensitivity of these viruses to anti-neuraminidase drugs, based upon a fluorometric neuraminidase enzymatic test. our study was performed on clinical samples colle ... | 2005 | 16125799 |
| replication of respiratory viruses, particularly influenza virus, rhinovirus, and coronavirus in huh7 hepatocarcinoma cell line. | detection of viral antigens and isolation methods has long been used for the diagnosis of respiratory virus infections. the objective was to determine the ability of huh7 cells to support the replication of prototype and wild strains of respiratory viruses. the cell culture-adapted strains of influenza viruses a and b, parainfluenza viruses 1-4, respiratory syncytial viruses a and b, both strains of the human metapneumoviruses, numerous rhinoviruses, most of the adenoviruses, coronaviruses 229e ... | 2005 | 16121382 |
| respiratory disease caused by a species b2 adenovirus in a military camp in turkey. | in april 2004, two patients were admitted to hospital in berlin, germany, with clinical signs of acute respiratory infection after returning from a military exercise in their home country of turkey. they were admitted to a high security infectious disease unit as epidemiological data pointed to an outbreak of unknown etiology. samples taken at the time of admission proved to be strongly positive for adenovirus by pcr, but negative for influenza a/h1n1 virus, influenza a/h3n2 virus, influenza b v ... | 2005 | 16121380 |
| annual report of the national influenza surveillance scheme, 2004. | the national influenza surveillance scheme includes data on influenza-like illness from sentinel general practitioner practices, laboratory reports of influenza from national notifiable diseases surveillance scheme and absenteeism data from a national employer. in 2004, 2,116 cases of laboratory-confirmed influenza-like illness were reported, which was 41 per cent lower than the previous year. peak activity was recorded in september, a month later than in 2003. influenza a was again predominant ... | 2005 | 16119760 |
| [conjugates of pancreatic ribonuclease and ligand-free human serum albumin]. | conjugates of pancreatic rnase and ligand-free human serum albumin (lfhsa) have been obtained. the number of hydrophobic binding sites both for initial hsa and lfhsa has been determined by the polarised luminescence method. interaction between rnase and hsa involves additional electrovalent linkage. unlike initial enzyme, conjugates exhibit activity toward double-strand rna. after intravenous injection, transferase activity of unmodified enzyme remains in the blood during 20 min., whereas 30-40% ... | 2003 | 16119087 |
| influenza in taiwan: seasonality and vaccine strain match. | this article explores seasonality, epidemiology and dominant epidemic strains of influenza in taiwan. surveillance in taiwan demonstrates that influenza is a disease which occurs throughout the year but has peak activity in winter. due to the high mutability of influenza virus, effective vaccination is the best strategy for protection. although the world health organization-recommended vaccine compositions usually matched with around 77% of circulating strains worldwide, the rate of matching in ... | 2005 | 16118670 |
| [antivirals for influenza]. | this paper describes antivirals active against myxovirus influenzae (influenza vaccine excluded), together with their indications in inter-pandemic and pandemic situations. three kinds of antiviral drug, with different mechanisms of action, are active against myxovirus influenzae: the adamantanes (amantadine and rimantadine); ribavirin; and neuraminidase inhibitors (zanamivir and oseltamivir). amantadine is available in france but its indications are limited by its inactivity against influenza b ... | 2005 | 16114863 |
| molecular epidemiology of human respiratory syncytial virus in uruguay: 1985-2001--a review. | the variability of the g glycoprotein from human respiratory syncytial viruses (hrsv) (groups a and b) isolated during 17 consecutive epidemics in montevideo, uruguay have been analyzed. several annual epidemics were studied, where strains from groups a and b circulated together throughout the epidemics with predominance of one of them. usually, group a predominates, but in some epidemics group b is more frequently detected. to analyse the antigenic diversity of the strains, extracts of cells in ... | 2005 | 16113858 |
| [diagnostic tests: influenza a, b, c viruses]. | 2005 | 16111270 | |
| emerging infections and children: influenza and acute necrotizing encephalopathy. | 2005 | 16107062 | |
| multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca b/ann arbor/1/66. | cold-adapted (ca) b/ann arbor/1/66 is the influenza b virus strain master donor virus for flumist, a live, attenuated, influenza virus vaccine licensed in 2003 in the united states. each flumist vaccine strain contains six gene segments of the master donor virus; these master donor gene segments control the vaccine's replication and attenuation. these gene segments also express characteristic biological traits in model systems. unlike most virulent wild-type (wt) influenza b viruses, ca b/ann ar ... | 2005 | 16103152 |
| acute stress exposure prior to influenza vaccination enhances antibody response in women. | animal studies have shown that an acute stressor in close temporal proximity to immune challenge can enhance the response to delayed-type hypersensitivity and antibody response to vaccination. the current study examined the effects of acute exercise or mental stress prior to influenza vaccination on the subsequent antibody response to each of the three viral strains. sixty young healthy adults (31 men, 29 women) were randomly allocated to one of three task conditions: dynamic exercise, mental st ... | 2006 | 16102936 |
| [research on influenza virus inhibitors]. | 1969 | 16089155 | |
| in vitro and in vivo influenza virus-inhibitory effects of viramidine. | viramidine, the 3-carboxamidine derivative of ribavirin, was effective against a spectrum of influenza a (h1n1, h3n2 and h5n1) and b viruses in vitro, with the 50% effective concentration (ec50) ranging from 2 to 32 microg/ml. the mean 50% cytotoxic concentration (cc50) in the mdck cells used in these experiments was 760 microg/ml. ribavirin, run in parallel, had a similar antiviral spectrum, with ec50 values ranging from 0.6 to 5.5 microg/ml; the mean cc50 for ribavirin was 560 microg/ml. oral ... | 2005 | 16087250 |
| prevention and control of influenza. recommendations of the advisory committee on immunization practices (acip). | this report updates the 2004 recommendations by the advisory committee on immunization practices (acip) regarding the use of influenza vaccine and antiviral agents (cdc. prevention and control of influenza: recommendations of the advisory committee on immunization practices [acip]. mmwr 2004;53[no. rr-6]:1-40). the 2005 recommendations include new or updated information regarding 1) vaccination of persons with conditions leading to compromise of the respiratory system; 2) vaccination of health-c ... | 2005 | 16086456 |
| evaluation of three influenza a and b rapid antigen detection kits--update. | 2005 | 16085921 | |
| variation of the conserved neutralizing epitope in influenza b virus victoria group isolates in japan. | for almost 20 years, the neutralizing-epitope site specific for influenza b virus victoria group isolates was conserved at the "tip" of the hemagglutinin molecule; however, it was not detected in half of the isolates from the 2002-2003 epidemic in japan. amino acid substitutions (d164e or n165k) were observed at the "tip", and the epitope was altered. the viral antigenicities were affected, and human antibodies did not substantially inhibit the hemagglutination in the hemagglutination inhibition ... | 2005 | 16081981 |
| risk of acquiring influenza b in a nursing home from a culture-positive roommate. | 2005 | 16078980 | |
| update: influenza activity--us and worldwide, 2004-2005 season. | 2005 | 16076906 | |
| few but severe viral infections in children with cancer: a prospective rt-pcr and pcr-based 12-month study. | treatment of low-risk febrile episodes with oral administered antibiotics at home is a new approach in pediatric oncology and protective isolation is loosened in more centers. the impact of viral respiratory infections in febrile diseases in this population is still unclear in terms of occurrence and morbidity. | 2005 | 16047356 |
| childhood respiratory infections and hospital admissions for copd. | chronic obstructive pulmonary disease (copd) exacerbations are associated with viral infections. we wished to determine if respiratory viral infection of children in the community was associated with hospital admissions of patients with exacerbations of copd. | 2006 | 16046259 |
| influenza activity among the paediatric age group in chennai. | respiratory viral infections have a major impact on public health. acute respiratory infections largely caused by viruses, are the most common illnesses experienced by otherwise healthy adults and children. among the respiratory viruses, influenza viruses are known to cause outbreaks globally. information on the activity of influenza virus in our country is limited and none from chennai. the present study was carried out to isolate and identify the influenza virus serotypes causing acute respira ... | 2005 | 16037623 |
| [screening for new binding proteins which interact with bm2 of influenza b virus with yeast two-hybrid system]. | to explore the role of bm2 protein in the life cycle of influenza b virus. | 2005 | 16027793 |
| [quantitative fluorogenic real-time pcr assay for respiratory syncytial virus detection]. | to establish a rapid and objective quantitative fluorogenic real-time pcr assay for early detection of human respiratory syncytial virus (hrsv). | 2005 | 16027084 |
| post-viral influenza streptococcus pneumoniae pneumonia in an intravenous drug abuser. | viral influenza is a seasonal cause of community-acquired pneumonia (cap). viral influenza may be caused by influenza a or b and affect any age group. viral influenza a is usually more severe than influenza b in adults. viral influenza may present as 3 clinical scenarios: viral influenza alone, viral influenza followed in 1 to 3 days by staphylococcus aureus pneumonia, or viral influenza followed in 1 to 3 weeks by pneumonia caused by streptococcus pneumoniae or haemophilus influenzae. intraveno ... | 2005 | 16015228 |
| vaccination against influenza in rheumatoid arthritis: the effect of disease modifying drugs, including tnf alpha blockers. | to assess the efficacy and safety of vaccination against influenza virus in patients with rheumatoid arthritis, with special emphasis on the effect of disease modifying antirheumatic drugs (dmards), including tumour necrosis factor alpha (tnfalpha) blockers. | 2006 | 16014674 |
| development of cold agglutinin autoimmune hemolytic anemia during treatment for pediatric acute lymphoblastic leukemia. | autoimmune hemolytic anemia (aiha) is a potentially fatal complication of many lymphoid malignancies. those most often associated with aiha include chronic lymphocytic leukemia, b-cell lymphomas, and burkitt-type acute lymphoblastic leukemia (all) and are clonal populations of mature b cells. there have been no reports of patients with b-cell precursor all who developed aiha while undergoing chemotherapy, but aiha has been reported in a few patients with all after hematopoietic stem cell transpl ... | 2005 | 16012332 |
| human isg15 conjugation targets both ifn-induced and constitutively expressed proteins functioning in diverse cellular pathways. | ifn-alpha/beta plays an essential role in innate immunity against viral and bacterial infection. among the proteins induced by ifn-alpha/beta are the ubiquitin-like isg15 protein and its e1- (ube1l) and e2- (ubch8) conjugating enzymes, leading to the conjugation of isg15 to cellular proteins. it is likely that isg15 conjugation plays an important role in antiviral response because a human virus, influenza b virus, inhibits isg15 conjugation. however, the biological function of isg15 modification ... | 2005 | 16009940 |
| immune response after influenza vaccination in children with cancer. | to assess the immune response to inactivated trivalent split influenza vaccine in children with cancer. | 2005 | 16007602 |
| [influenza virus infections in infants aged less than two years old]. | influenza is a major cause of respiratory tract illness in infants. the clinical characteristics of these infections are non-specific and the burden of influenza is frequently underestimated in very young children. the objective of this study was to describe confirmed influenza infections in infants < 2 years attended in a level ii public hospital. a second-rate aim was to compare influenza infections in hospitalized infants with respiratory syncytial virus (vrs) infection in the same population ... | 2005 | 15989867 |
| update: influenza activity--united states and worldwide, 2004-05 season. | during the 2004-05 influenza season, influenza a (h1),* a (h3n2), and b viruses cocirculated worldwide, and influenza a (h3n2) viruses predominated. in addition, several asian countries continued to report widespread outbreaks of avian influenza a (h5n1) among poultry; in vietnam, thailand, and cambodia, these outbreaks were associated with severe illnesses and deaths among humans. in the united states, the 2004-05 influenza season peaked in february, was moderate, and was associated predominant ... | 2005 | 15988408 |
| vaccination of patients with haematological malignancies with one or two doses of influenza vaccine: a randomised study. | an open, randomised study was performed to determine whether two doses of influenza vaccine were more effective than one to elicit an immune response in 70 patients with haematological malignancies. the responses were not improved by two doses compared with one (influenza a virus serotypes h1/n1 18% vs. 22% and h3/n2 26% vs. 14%; influenza b 25% vs. 22%). the results were similar in patients with ongoing and discontinued therapy. patients treated with monoclonal antibodies for lymphoma had very ... | 2005 | 15982350 |
| influenza surveillance in victoria, 2004. | influenza activity during the traditional victorian influenza season from may to october 2004 was low with no well-defined peak. surveillance was based on sentinel general practice influenza-like illness (ili) notification with laboratory confirmation, locum service ili notification and laboratory reporting of influenza detections. eight hundred and fifteen consultations for ili were reported from 38 general practices and 216 consultations for ili were reported from the locum service. the averag ... | 2005 | 15966678 |
| significance of atypical pathogens among community-acquired pneumonia adult patients admitted to hospital in kuwait. | the aim of this study is to determine the microbial etiology and severity of community-acquired pneumonia (cap) in kuwait. | 2005 | 15961932 |
| statement on influenza vaccination for the 2005-2006 season. an advisory committee statement. | 2005 | 15959943 | |
| duration of virus shedding after trivalent intranasal live attenuated influenza vaccination in adults. | to characterize the probability and duration of viral shedding among adults given trivalent live attenuated influenza vaccine (laiv). | 2005 | 15954490 |
| structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors. | the structure-activity relationship (sar) of a novel hydrophobic binding interaction within a subsite of the influenza neuraminidase (na) active site was characterized and optimized for a series of trisubstituted pyrrolidine inhibitors modified at the 4-position. previously, potent inhibitors have targeted this subsite with hydrophilic substituents such as amines and guanidines. inhibitor-bound crystal structures revealed that hydrophobic substituents with sp(2) hybridization could achieve optim ... | 2005 | 15943472 |
| [relationship between infection burden and atherosclerosis and plaque feature]. | to evaluate the relationship between infection burden and coronary atherosclerosis and the plaque feature. | 2005 | 15932655 |
| universal influenza b vaccine based on the maturational cleavage site of the hemagglutinin precursor. | conventional influenza vaccines can prevent infection, but their efficacy depends on the degree of antigenic "match" between the strains used for vaccine preparation and those circulating in the population. a universal influenza vaccine based on invariant regions of the virus, able to provide broadly cross-reactive protection, without requiring continuous manufacturing update, would solve a major medical need. since the temporal and geographical dominance of the influenza virus type and/or subty ... | 2005 | 15919893 |
| analysis of synonymous codon usage in h5n1 virus and other influenza a viruses. | in this study, we calculated the codon usage bias in h5n1 virus and performed a comparative analysis of synonymous codon usage patterns in h5n1 virus, five other evolutionary related influenza a viruses and a influenza b virus. codon usage bias in h5n1 genome is a little slight, which is mainly determined by the base compositions on the third codon position. by comparing synonymous codon usage patterns in different viruses, we observed that the codon usage pattern of h5n1 virus is similar with o ... | 2005 | 15917130 |
| laboratory surveillance of influenza in northern greece, 1993-2003. | 2005 | 15902542 | |
| a single amino acid change in the c-terminal domain of the matrix protein m1 of influenza b virus confers mouse adaptation and virulence. | serial passage of an initially avirulent influenza b virus, b/memphis/12/97, resulted in the selection of a variant which was lethal in mice. virulence correlated with improved growth in vivo and prolonged replication. sequencing of the complete coding regions of the parent and mouse-adapted viruses revealed 8 amino acid differences. sequencing and characterization of intermediate passages suggested that one change in the c-terminal domain of the m1 protein, an asparagine to a serine at position ... | 2005 | 15892972 |
| detection and characterization of new influenza b virus variants in 2002. | one-hundred five influenza b-positive specimens obtained from southeast asia in 2002 were categorized on the basis of dna sequencing of ha1 gene as well as real-time pcr analysis of the na gene. phylogenetic analysis of the ha1 gene sequences showed that the majority of the viruses (96.2%) belonged to the b/victoria/2/87 lineage, while a smaller percentage of the viruses (3.8%) belonged to the b/yamagata/16/88 lineage. the b/yamagata/16/88 viruses displayed significant antigenic drift in the ded ... | 2005 | 15872264 |
| influenza. | 2004 | 15865706 | |
| development of three multiplex rt-pcr assays for the detection of 12 respiratory rna viruses. | three multiplex hemi-nested rt-pcr assays were developed to detect simultaneously 12 rna respiratory viruses: influenza viruses a, b and c, human respiratory syncytial virus (hrsv), human metapneumovirus (hmpv), parainfluenza virus types 1-4 (piv-1, -2, -3 and -4), human coronavirus oc43 and 229e (hcov) and rhinovirus (hrv). an internal amplification control was included in one of the rt-pcr assays. the rt-pcr multiplex 1 and the hemi-nested multiplex 1 detected 1 and 0.1 tcid50 of rsv a, respec ... | 2005 | 15847919 |
| myocardial ischaemia in a child infected with influenza b. | cardiac involvement is a rare complication of infection by the influenza b virus. it usually presents with ventricular dysfunction, arrhythmias, or both. we report a 13-year-old boy with clinical, electrocardiographic, and laboratory findings of myocardial ischaemia during an otherwise silent acute infection with influenza b. coronary endothelial injury constituted a potential underlying mechanism, and microthrombosis was promoted by high levels of lipoprotein(a) in the serum. | 2005 | 15845170 |
| drug screening for influenza neuraminidase inhibitors. | neuraminidase (na) is one of the most important targets to screen the drugs of anti-influenza virus a and b. after virtual screening approaches were applied to a compound database which possesses more than 10000 compound structures, 160 compounds were selected for bioactivity assay, then a high throughput screening (hts) model established for influenza virus na inhibitors was applied to detect these compounds. finally, three compounds among them displayed higher inhibitory activities, the range ... | 2005 | 15844351 |
| influence of additional acylation site(s) of influenza b virus hemagglutinin on syncytium formation. | we studied the effects of an increase in the hydrophobicity of the transmembrane domain (tm) and cytoplasmic tail (ct) of influenza b virus hemagglutinin (bha) on fusion activities. for this purpose, we created mutant has with novel acylation site(s) in the tm and/or ct. all mutants were able to induce hemifusion and to form fusion pores as well as could wild type (wt) bha. however, the ability of these mutants to form syncytia was impaired, indicating that the increase in the hydrophobicity of ... | 2005 | 15840961 |
| dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including h5n1 avian influenza. | the synthesis, antiviral and pharmacokinetic properties of zanamivir (zmv) dimers 8 and 13 are described. the compounds are highly potent neuraminidase (na) inhibitors which, along with dimer 3, are being investigated as potential second generation inhaled therapies both for the treatment of influenza and for prophylactic use. they show outstanding activity in a 1 week mouse influenza prophylaxis assay, and compared with zmv, high concentrations of 8 and 13 are found in rat lung tissue after 1 w ... | 2005 | 15828835 |
| factors influencing the effectiveness of oseltamivir and amantadine for the treatment of influenza: a multicenter study from japan of the 2002-2003 influenza season. | to evaluate the effectiveness of oseltamivir and amantadine for the treatment of influenza with respect to various clinical factors, a prospective multicenter study of the influenza season of 2002-2003 was done with 2163 patients whose condition was diagnosed by an antigen-detection test kit. | 2005 | 15825034 |
| [influenza b virus pneumonia after bone marrow transplantation: case report with emphasis to the high resolution computed tomography findings]. | nine year-old male patient, who underwent bone marrow transplantation because of acute myelogenous leukemia, presented with fever and dry cough three days after the procedure. the chest radiograph demonstrated bilateral diffuse reticular infiltrate. the high resolution computed tomography showed peribronchovascular interstitial thickening, peripheral small centrilobular nodules and areas of ground-glass attenuation. the bronchoalveolar lavage demonstrated positive direct fluorescence antibody te ... | 2005 | 15824866 |
| reappearance of influenza b/victoria/2/87-lineage viruses: epidemic activity, genetic diversity and vaccination efficacy in the finnish defence forces. | a new b/shangdong/7/97-like influenza virus (victoria/2/87 lineage) predominated during the 2002/2003 epidemic season in finland and was estimated to account for 2246 of the 13,496 feverish upper respiratory tract infections (uris) occurring among conscripts in the finnish army. the incidence (1716/10,000 conscripts) was indicative of moderate epidemic activity at most. analysis of the cross-reactive antibodies induced in 1988 suggests that the basis of the protection was probably established du ... | 2005 | 15816151 |
| update: influenza activity--united states, 2004-05 season. | this report summarizes influenza activity in the united states during october 3, 2004-march 26, 2005, updates the previous summary, and describes the composition of the 2005-06 influenza vaccine. influenza activity was moderate in the united states overall, but varied by region. preliminary data collected through the seven components of the cdc influenza surveillance indicate that national influenza activity peaked in early-february. | 2005 | 15815563 |
| evaluation of pcr testing of ethanol-fixed nasal swab specimens as an augmented surveillance strategy for influenza virus and adenovirus identification. | viral culture isolation has been widely accepted as the "gold standard" for laboratory confirmation of viral infection; however, it requires ultralow temperature specimen storage. storage of specimens in ethanol at room temperature could expand our ability to conduct active surveillance and retrospective screenings of viruses with rapid and inexpensive real-time pcr tests, including isolates from remote regions where freezing specimens for culture is not feasible. molecular methods allow for rap ... | 2005 | 15814997 |
| laboratory-based surveillance and molecular epidemiology of influenza virus in taiwan. | a laboratory-based surveillance network of 11 clinical virological laboratories for influenza viruses was established in taiwan under the coordination of the center for disease control and prevention (cdc), taiwan. from october 2000 to march 2004, 3,244 influenza viruses were isolated, including 1,969 influenza a and 1,275 influenza b viruses. the influenza infections usually occurred frequently in winter in the northern hemisphere. however, the influenza seasonality in taiwan was not clear duri ... | 2005 | 15814980 |
| i wish to comment on several points in the recent "guidelines". | 2005 | 15797370 | |
| cranberry juice constituents affect influenza virus adhesion and infectivity. | cranberry juice contains high molecular weight materials (ndm) that inhibit bacterial adhesion to host cells as well as the co-aggregation of many oral bacteria. because of its broad-spectrum activity, we investigated ndm's potential for inhibiting influenza virus adhesion to cells, and subsequent infectivity. hemagglutination (ha) of red blood cells (rbc) caused by representatives of both influenza virus a subtypes (h1n1)and h3n2) and the b type was inhibited by ndm at concentrations of 125 mic ... | 2005 | 15781126 |
| influenza in the world: september 2004-january 2005. | 2005 | 15779713 | |
| recommended composition of influenza virus vaccines for use in the 2005-2006 influenza season. | 2005 | 15771207 | |
| [analysis of influenza antibodies in normal people in jiangsu province in 2003 ]. | 2004 | 15769348 | |
| influenza-like illness criteria were poorly related to laboratory-confirmed influenza in a sentinel surveillance study. | to analyze the most related clinical data for influenza and the utility of influenza-like illness criteria as the clinical threshold for sampling in an influenza sentinel surveillance over a 3-year period. | 2005 | 15768487 |
| [influenza pandemic planning. national influenza pandemic plan]. | 2005 | 15768309 | |
| mutational pattern of influenza b viruses adapted to high growth replication in embryonated eggs. | improved replication of influenza viruses in embryonated chicken eggs (ce) permits increased vaccine production and availability. we investigated the growth properties of influenza b viruses in relation to specific mutations occurring after serial passage in ce. in serial passage experiments yielding high growth variants of b/victoria/504/2000, mutations predicted to alter amino acid (aa) composition occurred only near the receptor-binding pocket of the hemagglutinins (ha) and in no other genes. ... | 2004 | 15763145 |
| intradermal vaccination against influenza. | 2005 | 15758019 | |
| evaluation of three immunoassay kits for rapid detection of influenza virus a and b. | influenza causes high morbidity and mortality in very young and elderly individuals, which can be controlled with antivirals and/or vaccines. the success of therapeutic measures is predicated on the rapid and precise diagnosis of the infection. we compared three rapid influenza immunoassay (riia) kits for the diagnosis of influenza virus a and b using 178 respiratory specimens submitted for routine testing. bd directigen flu a+b (directigen), directigen ez flu a+b (ez), and now flu a now flu b ( ... | 2005 | 15753248 |
| update: influenza activity united states, 2004-05 season. | influenza activity has increased steadily in the united states since late december and, as of february 19, might not have peaked. laboratory-confirmed influenza infections have been reported from all 50 states. this report summarizes influenza activity during october 3, 2004-february 19, 2005. | 2005 | 15744226 |
| does this patient have influenza? | influenza vaccination lowers, but does not eliminate, the risk of influenza. making a reliable, rapid clinical diagnosis is essential to appropriate patient management that may be especially important during shortages of antiviral agents caused by high demand. | 2005 | 15728170 |
| clinical presentations for influenza and influenza-like illness in young, immunized soldiers. | concern about respiratory diseases in soldiers increased in the late 1990s as production of the successful adenovirus vaccines stopped and the possibilities of an emergent pandemic influenza strain and use of bioweapons by terrorists were seriously considered. current information on the causes and severity of influenza-like illness (ili) was lacking. viral agents and clinical presentations were described in a population of soldiers highly immunized for influenza. using standard virus isolation t ... | 2005 | 15724862 |
| two formulations of the industrial surfactant, toximul, differentially reduce mouse weight gain and hepatic glycogen in vivo during early development: effects of exposure to influenza b virus. | previous studies demonstrated that young mice exposed chronically to industrial surfactant (is) do not exhibit obvious adverse health effects, but do have persistently reduced body weights and compromised hepatic energy metabolism. the present study examined the time course of effects of two formulations of the toximul (tox) class of anionic/nonionic is on body weights and liver glycogen (+/-virus) during early development. results showed that effects differed in two commonly used strains of mic ... | 2005 | 15722095 |
| [evaluation of immunochromatography test for rapid detection of influenza a and b viruses]. | 2005 | 15717481 | |
| impact of influenza vaccination on seasonal mortality in the us elderly population. | observational studies report that influenza vaccination reduces winter mortality risk from any cause by 50% among the elderly. influenza vaccination coverage among elderly persons (> or =65 years) in the united states increased from between 15% and 20% before 1980 to 65% in 2001. unexpectedly, estimates of influenza-related mortality in this age group also increased during this period. we tried to reconcile these conflicting findings by adjusting excess mortality estimates for aging and increase ... | 2005 | 15710788 |
| evaluation of a multiplex real-time reverse transcriptase pcr assay for detection and differentiation of influenza viruses a and b during the 2001-2002 influenza season in israel. | the ability to rapidly diagnose influenza virus infections is of the utmost importance in the evaluation of patients with upper respiratory tract infections. it is also important for the influenza surveillance activities performed by national influenza centers. in the present study we modified a multiplex real-time reverse transcriptase pcr (rt-pcr) assay (which uses taqman chemistry) and evaluated it for its ability to detect and concomitantly differentiate influenza viruses a and b in 370 pati ... | 2005 | 15695650 |
| invasive pulmonary aspergillosis associated with influenza b. | invasive pulmonary aspergillosis (ipa) usually occurs in immunocompromised patients. however, rarely, this infection can occur in normal hosts. this review of the literature identified 13 cases of ipa associated with influenza, of which 12 had influenza a and the type of influenza was not mentioned in the other case. reported here is a case of ipa, which was associated with influenza b, in a 63-year-old immunocompetent woman. her lungs showed gross invasion and she was treated with itraconazole ... | 2005 | 15691249 |
| [influenza epidemiologic and virologic surveillance in antananarivo from 1995 to 2002]. | the "institut pasteur de madagascar" virology laboratory is the national who centre for influenza surveillance in madagascar. on this surveillance collaborate the ministry of health with 9 sentinel centres. in the present article, the authors relate the results of influenza surveillance in antananarivo between 1995 and 2002. among 6341 patients with nasal and/or pharyngeal swabs, influenza virus were isolated from 427 patients (6.7%): 307 (68.4%) influenza virus a (h3n2), 124 (27.1%) influenza v ... | 2003 | 15678811 |
| antibody response to influenza vaccination in healthy adults. | the aim of this study was to assess antibody response in 184 healthy adults vaccinated with split influenza vaccine (begrivac, chiron behring). response to hemagglutinin and neuraminidase was assessed before vaccination and after 1 month by hemagglutination inhibition test and neuraminidase inhibition test. after vaccination, statistically significant increases of antibody titers, both for hemagglutinins and for neuraminidases, were observed. the post-vaccination proportion of persons with prote ... | 2004 | 15671759 |
| characterization of recombinant influenza b viruses with key neuraminidase inhibitor resistance mutations. | objectives and methods: an influenza b virus plasmid-based rescue system was used to introduce site-specific mutations, previously observed in neuraminidase (na) inhibitor-resistant viruses, into the na protein of six recombinant viruses. three mutations observed only among in vitro selected zanamivir-resistant influenza a mutants were introduced into the b/beijing/1/87 virus na protein, to change residue e116 to glycine, alanine or aspartic acid. residue e116 was also mutated to valine, a mutat ... | 2005 | 15665027 |
| simple and rapid strategy for genetic characterization of influenza b virus reassortants. | genetic reassortment of influenza viruses is widely used for creating viruses with specific phenotypes. reassortment of two influenza viruses, each with eight rna segments potentially yields as many as 256 gene segment combinations. therefore, confirmation that progeny viruses possess genomes corresponding to the specified phenotypes can be laborious and time-consuming. to establish a convenient method for genotyping influenza virus reassortants, we adapted single-strand conformation polymorphis ... | 2005 | 15664070 |
| association of influenza epidemics with global climate variability. | the reasons for the seasonality and annual changes in the impact of influenza epidemics remain poorly understood. we investigated the covariations between a major component of climate, namely the el niño southern oscillation (enso), and indicators of the impact of influenza, as measured by morbidity, excess mortality and viral subtypes collected in france during the period 1971-2002. we show that both the circulating subtype and the magnitude of enso are associated with the impact of influenza e ... | 2004 | 15648600 |
| influenza in canada: 2003-2004 season. | 2005 | 15645607 | |
| [clinical characteristics of children hospitalized for influenza virus infection]. | the clinical manifestations of influenza virus are fairly nonspecific and are similar to those of other viral infections, respiratory processes due to other causes and even septic disease in neonates. few studies have been performed of the clinical characteristics of influenza virus infection in hospitalized children. | 2005 | 15642235 |
| [safety and immunogenicity of split vaccines of influenza viruses]. | to evaluate the safety and immunogenicity of influenza split vaccine. | 2004 | 15640848 |
| influenza a viruses of migrating wild aquatic birds in north america. | surveillance of north america's wild ducks and shorebirds for 26 and 16 years, respectively, revealed differences in the prevalence of orthomyxoviruses between these hosts. shorebirds had a high frequency of influenza a virus isolation during their northern migration, while wild ducks had high virus isolation frequencies during their southern migration. some subtypes of influenza occurred regularly in both hosts with a 2-year periodicity, whereas others rarely occurred. hemagglutinin subtypes h1 ... | 2004 | 15631061 |
| [comparison of three rapid diagnostic kits using immunochromatography for detection of influenza a virsuses]. | in 2004, 3 new rapid influenza diagnostic kits using immunochromatography that allow type differentiation became commercially available. they are the espline influenza a & b-n (fujirebio corp., japan: espline-n hereafter), quickvue rapid sp influ (quidel corp., usa: quickvue), and poctem influenza a/b (international reagents corp., japan: poctem). the authors performed a prospective study that compared the usefulness among the 3 kits in 151 children with suspected influenza, who were examined wi ... | 2004 | 15628525 |
| influenza b virus associated pneumonia: report of one case. | influenza a virus is a more common cause of pneumonia than influenza b virus. influenza virus pneumonia complicated with acute respiratory distress syndrome (ards) is rare and has a high mortality rate. in addition to pneumonia, influenza occasionally causes neurologic, cardiac, renal, or muscular complications. hepatic involvement in influenza virus infection has been rarely reported. we reported the case of a 7-year-old girl who was initially treated for upper respiratory tract infection, but ... | 2004 | 15624374 |
| [aetiologic study on the outbreaks of influenza-like disease in shenzhen]. | during march to may in 1994, the outbreaks of influenza like disease occurred in shenzhen city. the outbreaks were caused by influenza b virus demonstrated by aetiologic and serological studies. the antigenic analysis indicated that the isolates were antigenically similar to b/shanghai/1/93 and b/guangdong/8/93 strains (both are b/victoria/2/87. like virus). the genetic analysis showed that the ha1 genes of the isolates were 1038 nucleotides in length coding for ha1 protein of 346 amino acids wh ... | 1997 | 15619828 |
| method for detection of respiratory viruses in the sputa of patients with cystic fibrosis. | since the role of respiratory viruses in lung exacerbations of patients with cystic fibrosis has been hampered by the difficulty of detecting viruses in viscous sputum specimens, a multiplex reverse transcriptase pcr (rt-pcr) assay combined with colorimetric amplicon detection was tested for the identification of seven common respiratory viruses in the sputa of cystic fibrosis patients. of 52 sputa from 38 patients, 12 (23%) samples from 12 patients were positive for a respiratory virus (4 for i ... | 2005 | 15616837 |
| safety, immunogenicity and efficacy of intranasal, live attenuated influenza vaccine. | data supporting the use of the live attenuated influenza vaccine (laiv) in children and adults is reviewed, and the development and characteristics of the vaccine are summarized. the vaccine is highly effective and well tolerated in children and adults from 5 to 49 years of age. correlates of immune protection include serum hemagglutination-inhibition antibody and secretory immunoglobulin a. efficacy against antigenically well-matched epidemic influenza strains was high at 92%. in 1 year, despit ... | 2004 | 15606348 |