Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| plasma epstein-barr viral deoxyribonucleic acid predicts worse outcomes in pediatric nonmetastatic nasopharyngeal carcinoma patients: an observational study of 89 cases in an endemic area. | to evaluate the clinical significance of pretreatment levels of plasma epstein-barr virus dna (pebv dna) on prognoses in pediatric nasopharyngeal carcinoma (npc) patients. eighty-nine patients aged 21 years old or younger with nonmetastatic npc were evaluated to determine the effect of pebv dna levels on progression-free survival (pfs), distant metastasis-free survival (dmfs), and overall survival (os). survival probabilities in patient groups that were segregated by clinical stage or pebv dna l ... | 2015 | 26683909 |
| induction of mapk- and ros-dependent autophagy and apoptosis in gastric carcinoma by combination of romidepsin and bortezomib. | proteasome inhibitors and histone deacetylase (hdac) inhibitors can synergistically induce apoptotic cell death in certain cancer cell types but their combinatorial effect on the induction of autophagy remains unknown. here, we investigated the combinatorial effects of a proteasome inhibitor, bortezomib, and an hdac inhibitor, romidepsin, on the induction of apoptotic and autophagic cell death in gastric carcinoma (gc) cells. isobologram analysis showed that low nanomolar concentrations of borte ... | 2016 | 26683357 |
| lack of association between epstein-barr virus and epithelial malignancies developed after kidney transplantation. | organ transplant recipients are at high risk of developing malignancies due to immunosuppressive regimens. unlike post-transplant lymphoproliferative diseases (ptlds), where epstein-barr virus (ebv) plays an etiological role, there are conflicting data regarding the association of ebv with post-transplant epithelial malignancies. in order to clarify the role of ebv in carcinomas that develop after solid-organ transplantation, the presence of ebv infection in the carcinomas of post-kidney transpl ... | 2003 | 26680970 |
| infectious mononucleosis, other infections and prostate-specific antigen concentration as a marker of prostate involvement during infection. | although epstein-barr virus has been detected in prostate tissue, no associations have been observed with prostate cancer in the few studies conducted to date. one possible reason for these null findings may be use of cumulative exposure measures that do not inform the timing of infection, i.e., childhood versus adolescence/early adulthood when infection is more likely to manifest as infectious mononucleosis (im). we sought to determine the influence of young adult-onset im on the prostate by me ... | 2016 | 26678984 |
| viralepi v1.0: a high-throughput spectrum of viral epigenomic methylation profiles from diverse diseases. | to develop a computational resource for viral epigenomic methylation profiles from diverse diseases. | 2016 | 26678852 |
| association of interferon lambda-1 with herpes simplex viruses-1 and -2, epstein-barr virus, and human cytomegalovirus in chronic periodontitis. | periodontal tissues facilitate the homing of herpes viruses that elicit the immune-inflammatory response releasing the interferons (ifn). ifn lambda-1 (λ1) can suppress the replication of viruses, and induces the antiviral mechanism. the aim of the present study was to evaluate the association between ifn-λ1 and periodontal herpes viruses in the immunoregulation of chronic periodontal disease. | 2015 | 26677065 |
| the impact of the cumulative dose of cisplatin during concurrent chemoradiotherapy on the clinical outcomes of patients with advanced-stage nasopharyngeal carcinoma in an era of intensity-modulated radiotherapy. | the impact of cumulative dose of cisplatin on clinical outcomes of nasopharyngeal carcinoma (npc) patients who received intensity-modulated radiotherapy (imrt) was evaluated. | 2015 | 26675209 |
| a single nucleotide polymorphism in the epstein-barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma. | epstein-barr virus (ebv) commonly infects the general population and has been associated with nasopharyngeal carcinoma (npc), which has a high incidence in certain regions. this study aimed to address how ebv variations contribute to the risk of npc. | 2015 | 26675171 |
| viruses, other pathogenic microorganisms and esophageal cancer. | esophageal cancer (ec) is the eighth most prevalent malignant tumor and the sixth leading cause of cancer mortality throughout the world. despite the technical developments in diagnosis and treatment, the 5-year survival rate is still low. the etiology of ec remains poorly understood; multiple risk factors may be involved and account for the great variation in ec incidence in different geographic regions. | 2015 | 26674173 |
| accumulation mechanisms of cd4(+)cd25(+)foxp3(+) regulatory t cells in ebv-associated gastric carcinoma. | approximately 10% of gastric carcinomas are associated with epstein-barr virus (ebv) and are defined as ebv-associated gastric carcinomas (ebvagcs). ebvagcs are known to be accompanied by massive cd8(+) cytotoxic t cell (ctl) infiltration; however, adoptive cellular immunotherapy based on ebv-specific cd8(+) ctls has been explored with limited success. because regulatory t cells (tregs) are regarded as a critical hurdle in anti-tumour immunity, we assessed the distribution of tregs in 45 cases o ... | 2015 | 26673957 |
| prognostic value of tumor-infiltrating lymphocytes in epstein-barr virus-associated gastric cancer. | this study explored the prognostic impact of tumor-infiltrating lymphocytes (tils) and investigated whether three histologic subtypes (lymphoepithelioma-like carcinoma, carcinoma with crohn's disease-like lymphoid reaction, and conventional-type adenocarcinoma) could stratify a prognostic subset for patients with epstein-barr virus (ebv)-associated gastric cancer (ebvagc). | 2016 | 26673353 |
| positivity of both plasma epstein-barr virus dna and serum epstein-barr virus capsid specific immunoglobulin a is a better prognostic biomarker for nasopharyngeal carcinoma. | positivity of plasma epstein-barr virus (ebv)-dna or serum virus capsid antigen-specific iga (vca-iga) is a biomarker for the prognosis of nasopharyngeal carcinoma (npc). the objective of this study was to determine the value of positivity for plasma ebv-dna and/or vca-iga in predicting the survival of patients with npc. | 2014 | 26673151 |
| preemptive therapy with ganciclovir and cytomegalovirus hyperimmune globulin delayed the onset of epstein-barr virus-associated post-transplant acute limbic encephalitis. | 2015 | 26671100 | |
| sudden onset unilateral sensorineural hearing loss after rabies vaccination. | a 33-year-old man developed profound sudden onset right-sided hearing loss with tinnitus and vertigo, within 24 h of pretravel rabies vaccination. there was no history of upper respiratory tract infection, systemic illness, ototoxic medication or trauma, and normal otoscopic examination. pure tone audiograms (pta) demonstrated right-sided sensorineural hearing loss (thresholds 90-100 db) and normal left-sided hearing. mri internal acoustic meatus, viral serology (hepatitis b, c, hiv and cytomega ... | 2015 | 26670892 |
| a case of mature natural killer-cell neoplasm manifesting multiple choroidal lesions: primary intraocular natural killer-cell lymphoma. | natural killer (nk) cell neoplasm is a rare disease that follows an acute course and has a poor prognosis. it usually emerges from the nose and appears in the ocular tissue as a metastasis. herein, we describe a case of nk-cell neoplasm in which the eye was considered to be the primary organ. | 2017 | 26668579 |
| nhl - extranodal t-cell lymphoma. | extranodal nk/t-cell lymphoma, nasal type (enkl) is a rare lymphoid neoplasm that in the past has been grouped with a variety of granulomatous diseases. enkl occurs in all age groups. however, it seems to occur more often in people in their 50s and affects more men than women. it is strongly linked to the epstein-barr virus (ebv), especially in people of asian countries. because this type of lymphoma occurs in organs or tissues other than lymph nodes, it is called enkl. this is a case report of ... | 2017 | 26668464 |
| molecular concept in human oral cancer. | the incidence of oral cancer remains high in both asian and western countries. several risk factors associated with development of oral cancer are now well-known, including tobacco chewing, smoking, and alcohol consumption. cancerous risk factors may cause many genetic events through chromosomal alteration or mutations in genetic material and lead to progression and development of oral cancer through histological progress, carcinogenesis. oral squamous carcinogenesis is a multistep process in wh ... | 2017 | 26668446 |
| cell-free epstein-barr virus-dna in patients with nasopharyngeal carcinoma: plasma versus urine. | the purpose of this study was to explore urinary epstein-barr virus (ebv)-dna as a potential biomarker in patients with nasopharyngeal carcinoma (npc). | 2016 | 26667883 |
| [rs3pe syndrome associated with senile epstein-barr virus-positive diffuse large b cell lymphoma of a patient with colon cancer]. | a 75-year-old woman consulted her doctor in january 2014 because of pain in the dorsum of the hands, elbows, shoulders, and knees, bilaterally, and was diagnosed as having remitting seronegative symmetrical synovitis with pitting edema (rs3pe) syndrome. although the joint pain improved with low-dose prednisolone administration, she was referred to our department in april of 2014 because she had become aware of swelling of the right cervical lymph node. biopsy of the lymph node demonstrated that ... | 2015 | 26666720 |
| association between herpesviruses and chronic periodontitis: a meta-analysis based on case-control studies. | numerous studies have investigated the associations between herpesviruses and chronic periodontitis; however, the results remain controversial. to derive a more precise estimation, a meta-analysis on all available studies was performed to identify the association between herpesviruses and chronic periodontitis. | 2015 | 26666412 |
| 5-hydroxymethylation of the ebv genome regulates the latent to lytic switch. | latent epstein-barr virus (ebv) infection and cellular hypermethylation are hallmarks of undifferentiated nasopharyngeal carcinoma (npc). however, ebv infection of normal oral epithelial cells is confined to differentiated cells and is lytic. here we demonstrate that the ebv genome can become 5-hydroxymethylated and that this dna modification affects ebv lytic reactivation. we show that global 5-hydroxymethylcytosine (5hmc)-modified dna accumulates during normal epithelial-cell differentiation, ... | 2015 | 26663912 |
| positive epstein-barr virus detection and mortality in respiratory failure patients admitted to the intensive care unit. | epstein-barr virus (ebv) infection may induce immune suppression in several ways, which may influence the proper host response to other pathogensand lead to a bad outcome of critically ill patients. | 2015 | 26663042 |
| saliva and viral infections. | over the last 10 years there have been only a handful of publications dealing with the oral virome, which is in contrast to the oral microbiome, an area that has seen considerable interest. here, we survey viral infections in general and then focus on those viruses that are found in and/or are transmitted via the oral cavity; norovirus, rabies, human papillomavirus, epstein-barr virus, herpes simplex viruses, hepatitis c virus, and hiv. increasingly, viral infections have been diagnosed using an ... | 2016 | 26662485 |
| evaluation of a standardised real-time pcr based dna-detection method (realstar®) in whole blood for the diagnosis of primary human cytomegalovirus (cmv) infections in immunocompetent patients. | cytomegalovirus (cmv) dna detection in blood could, as a supplementary test to serology, improve the accuracy and speed of diagnosis of an acute cmv infection. in this study we evaluated the performance of a commercially available and standardised cmv pcr assay in whole blood for the diagnosis of a primary infection in immunocompetent adults. moreover, the kinetics of viral dna was evaluated in order to provide a time frame in which viral dna could be detected during an acute primary infection. ... | 2016 | 26661089 |
| epigenetic alterations in epstein-barr virus-associated diseases. | latent epstein-bar virus genomes undergo epigenetic modifications which are dependent on the respective tissue type and cellular phenotype. these define distinct viral epigenotypes corresponding with latent viral gene expression profiles. viral latent membrane proteins 1 and 2a can induce cellular dna methyltransferases, thereby influencing the methylation status of the viral and cellular genomes. therefore, not only the viral genomes carry epigenetic modifications, but also the cellular genomes ... | 2016 | 26659263 |
| differential cellular localization of epstein-barr virus and human cytomegalovirus in the colonic mucosa of patients with active or quiescent inflammatory bowel disease. | the role of human cytomegalovirus (hcmv) and epstein-barr virus (ebv) in the exacerbation of inflammatory bowel disease (ibd) is still uncertain. we prospectively investigated the presence of ebv and hcmv infection in both epithelial and immune cells of colonic mucosa of ibd patients, both refractory and responders to standard therapies, in comparison with patients suffering from irritable bowel syndrome who were considered as controls, by using quantitative real-time polymerase chain reaction, ... | 2016 | 26659090 |
| epstein-barr virus reactivation in extranodal natural killer/t-cell lymphoma patients: a previously unrecognized serious adverse event in a pilot study with romidepsin. | romidepsin, a histone deacetylase (hdac) inhibitor, has been approved for the treatment of relapsed and refractory peripheral t-cell lymphoma. however, the efficacy and safety of romidepsin has never been studied in patients with relapsed or refractory extranodal natural killer (nk)/t-cell lymphoma (enktl). | 2016 | 26658891 |
| plasma epstein barr viral load in adult-onset hodgkin lymphoma in south india. | epstein barr virus (ebv) dna load is increasingly being used as a noninvasive biomarker for detecting ebv association in lymphomas. since there is a need of data from india, we undertook to prospectively evaluate plasma ebv dna load as a marker of ebv association in newly diagnosed adult-onset hodgkin lymphoma (hl). | 2016 | 26657995 |
| comparative mutagenesis of pseudorabies virus and epstein-barr virus gh identifies a structural determinant within domain iii of gh required for surface expression and entry function. | herpesviruses infect cells using the conserved core fusion machinery composed of glycoprotein b (gb) and gh/gl. the gh/gl complex plays an essential but still poorly characterized role in membrane fusion and cell tropism. our previous studies demonstrated that the conserved disulfide bond (db) c278/c335 in domain ii (d-ii) of epstein-barr virus (ebv) gh has an epithelial cell-specific function, whereas the interface of d-ii/d-iii is involved in formation of the b cell entry complex by binding to ... | 2015 | 26656711 |
| scanning mutagenesis of human cytomegalovirus glycoprotein gh/gl. | the core, conserved function of the herpesvirus gh/gl is to promote gb-mediated membrane fusion during entry, although the mechanism is poorly understood. the human cytomegalovirus (hcmv) gh/gl can exist as either the gh/gl/go trimer or the gh/gl/ul128/ul130/ul131 (gh/gl/ul128-131) pentamer. one model suggests that gh/gl/go provides the core fusion role during entry into all cells within the broad tropism of hcmv, whereas gh/gl/ul128-131 acts at an earlier stage, by a distinct receptor-binding m ... | 2015 | 26656708 |
| a meta-analysis of interaction between epstein-barr virus and hla-drb1*1501 on risk of multiple sclerosis. | infection with epstein-barr virus (ebv) and hla-drb1*1501-positivity is a risk factor for multiple sclerosis (ms), but whether an interaction between these two factors causes ms is unclear. we therefore conducted a meta-analysis on the effect of the interaction between hla-drb1*1501 and ebv infection on ms. searches of pubmed, web of science, china national knowledge infrastructure (cnki), and the wanfan databases through february 2015 yielded 5 studies that met the criteria for inclusion in the ... | 2015 | 26656273 |
| ebv status and thiopurine use in pediatric ibd. | epstein barr virus (ebv) is a human herpes virus that infects 90% of the world's population and has been linked to the development of lymphoproliferative disorders (lpds) and immunosuppression. primary ebv infection in patients with ibd on thiopurines is a risk factor for lpd, including lymphoma. we aimed to describe ebv status in a pediatric population with ibd with an emphasis on those initiating thiopurines. | 2016 | 26655944 |
| decrease in seroprevalence for herpesviruses among pregnant women in finland: cross-sectional study of three time points 1992, 2002 and 2012. | maternal herpesvirus infections during pregnancy may cause fetal and neonatal infections. we investigated the seroprevalence of five herpesviruses: cytomegalovirus (cmv), herpes simplex virus (hsv) 1 and 2, varicella zoster virus (vzv) and epstein-barr virus (ebv) in randomly selected samples from pregnant finnish women from the years 1992, 2002 and 2012. over 20 years, the seroprevalences decreased significantly for cmv from 84.5% to 71.5% (p = 0.007) and hsv-1 from 69.5% to 45% (p < 0.001). th ... | 2016 | 26654892 |
| repression of ciita by the epstein-barr virus transcription factor zta is independent of its dimerization and dna binding. | repression of the cellular ciita gene is part of the immune evasion strategy of the γherpes virus epstein-barr virus (ebv) during its lytic replication cycle in b-cells. in part, this is mediated through downregulation of mhc class ii gene expression via the targeted repression of ciita, the cellular master regulator of mhc class ii gene expression. this repression is achieved through a reduction in ciita promoter activity, initiated by the ebv transcription and replication factor, zta (bzlf1, e ... | 2016 | 26653871 |
| novel targets for natural killer/t-cell lymphoma immunotherapy. | extranodal natural killer/t-cell lymphoma, nasal type (nktl) is a rare but highly aggressive epstein-barr virus-related malignancy, which mainly occurs in nasopharyngeal and nasal/paranasal areas. in addition to its high prevalence in asian, central american and south american populations, its incidence rate has been gradually increasing in western countries. the current mainstay of treatment is a combination of multiple chemotherapies and irradiation. although chemoradiotherapy can cure nktl, i ... | 2016 | 26642249 |
| evaluation of a multiplex pcr assay for detection of cytomegalovirus in stool samples from patients with ulcerative colitis. | to evaluate a multiplex pcr assay for the detection of bacterial and viral enteropathogens in stool samples from patients with ulcerative colitis (uc). | 2015 | 26640344 |
| human papillomavirus and epstein-barr virus in nasopharyngeal carcinoma in a non-endemic eastern european population. | nasopharyngeal carcinoma (npc) is a rare malignancy in the czech republic and slovakia, with the standardized incidence rate of < 1:100000 person-years. viral status of npc in these non-endemic eastern european regions is currently unknown. in a retrospective study, we evaluated the presence of ebv and hpv in 62 npc cases. ebv status was determined by the use of in situ hybridization (ish) for ebv encoded small rna 1 (eber1). hpv status was examined with p16 immunohistochemistry, dna ish and dna ... | 2016 | 26639240 |
| the participation of p53 and bcl-2 proteins in gastric carcinomas associated with helicobacterpylori and/or epstein-barr virus (ebv). | in the presented studies p53 and bcl-2 proteins expression were evaluated in samples of gastric carcinomas in patients with helicobacter pylori or ebv or without h. pylori/ebv infection. the studies were conducted on 64 adult patients with gastric adenocarcinomas: 16 patients with h. pylori (caga+)-positivity (group 1), 14 with ebv-positive tumours (group 2), 12 with h. pylori/ebv-positive tumours (group 3) and 22 patients with h. pylori/ebv-negative tumours (group 4). h. pylori presence in gast ... | 2015 | 26638529 |
| antibodies specific for epstein-barr virus nuclear antigen-1 cross-react with human heterogeneous nuclear ribonucleoprotein l. | epstein-barr virus (ebv) is associated with multiple sclerosis (ms), and antibodies to the ebv nuclear antigen-1 (ebna-1) are consistently increased in ms patients. the hypothesis of this study is that anti-ebna-1 antibodies cross-react with a self antigen in ms patients. we affinity purified anti-ebna-1 antibodies from human plasma, used the anti-ebna-1 to immunoprecipitate antigens from human brain, and identified bound antigens with mass spectrometry. anti-ebna-1 consistently bound heterogene ... | 2016 | 26637929 |
| hla and risk of diffuse large b cell lymphoma after solid organ transplantation. | solid organ transplant recipients have heightened risk for diffuse large b cell lymphoma (dlbcl). the role of donor-recipient hla mismatch and recipient hla type on dlbcl risk are not well established. | 2016 | 26636741 |
| epstein-barr and cytomegalovirus dna salivary shedding correlate with long-term plasma hiv rna detection in hiv-infected men who have sex with men. | the aim of the study was to evaluate cytomegalovirus (cmv) and epstein-barr virus (ebv) dna salivary shedding in hiv-positive men who have sex with men (msm) and to determine whether viro-immunological parameters and long-term (24 months) plasma hiv rna (phiv) detection may predict herpesviruses replication. a total of 193 hiv-positive msm were consecutively recruited (mean cd4+ cell count 607 cells/mm(3) and mean nadir value 333 cells/mm(3) ); phiv was analyzed for 24 months prior to saliva sam ... | 2016 | 26636290 |
| the role of epstein-barr virus lmp-1 immunohistochemical staining in childhood hodgkin lymphoma. | there are a few published studies about prognostic markers of epstein-b virus (ebv) related to outcomes in pediatric hodgkin lymphoma (hl). | 2015 | 26635935 |
| cytomegalovirus reactivation and its clinical impact in patients with solid tumors. | cytomegalovirus reactivation can be life threatening. however, little evidence on its incidence in solid cancers is available. therefore our single center cytomegalovirus polymerase chain reaction database with altogether 890 cmv positive blood serum samples of mainly hematological and oncological patients was retrospectively analyzed to examine the occurrence of cytomegalovirus reactivation in patients with solid tumors, resulting in 107 patients tested positive for cytomegalovirus reactivation ... | 2015 | 26635891 |
| a diverse repertoire of cd4 t cells targets the immediate-early 1 protein of human cytomegalovirus. | t-cell responses to the immediate-early 1 (ie-1) protein of human cytomegalovirus (hcmv) are associated with protection from viral disease. thus, ie-1 is a promising target for immunotherapy. cd8 t-cell responses to ie-1 are generally strong. in contrast, cd4 t-cell responses to ie-1 were described to be comparatively infrequent or undetectable in hcmv carriers, and information on their target epitopes and their function has been limited. to analyze the repertoire of ie-1-specific cd4 t cells, w ... | 2015 | 26635812 |
| the expression of a viral microrna is regulated by clustering to allow optimal b cell transformation. | the epstein-barr virus (ebv) transforms b cells by expressing latent proteins and the bhrf1 microrna cluster. mir-bhrf1-3, its most transforming member, belongs to the recently identified group of weakly expressed micrornas. we show here that mir-bhrf1-3 displays an unusually low propensity to form a stem-loop structure, an effect potentiated by mir-bhrf1-3's proximity to the bhrf1 polya site. cloning mir-bhrf1-2 or a cellular microrna, but not a ribozyme, 5' of mir-bhrf1-3 markedly enhanced its ... | 2016 | 26635399 |
| dynamic expression of viral and cellular micrornas in infectious mononucleosis caused by primary epstein-barr virus infection in children. | epstein-barr virus (ebv) was the first virus identified to encode micrornas (mirnas). both of viral and human cellular mirnas are important in ebv infection. however, the dynamic expression profile of mirnas during primary ebv infection was unknown. this study aimed to investigate the dynamic expression profile of viral and cellular mirnas in infectious mononucleosis (im) caused by primary ebv infection. | 2015 | 26634702 |
| t-cell receptor binding affects the dynamics of the peptide/mhc-i complex. | the recognition of peptide/mhc by t-cell receptors is one of the most important interactions in the adaptive immune system. a large number of computational studies have investigated the structural dynamics of this interaction. however, to date only limited attention has been paid to differences between the dynamics of peptide/mhc with the t-cell receptor bound and unbound. here we present the first large-scale molecular dynamics simulation study of this type investigating hla-b*08:01 in complex ... | 2016 | 26633740 |
| fever, dry cough and exertional dyspnea: pulmonary lymphomatoid granulomatosis masquerading as pneumonia, granulomatosis with polyangiitis and infectious mononucleosis. | lymphomatoid granulomatosis (lyg) is a rare epstein-barr virus-associated lymphoproliferative disorder. the disease lacks specific clinical and radiological manifestations, which may delay a definitive diagnosis. we report the case of a 39-year-old man with pulmonary lyg who presented to a hospital after experiencing three months of fever, weight loss, dry cough and exertional dyspnea. he was initially misdiagnosed with pneumonia, granulomatosis with polyangiitis and infectious mononucleosis due ... | 2015 | 26631890 |
| epstein-barr virus-associated lymphoproliferative disorders: experimental and clinical developments. | epstein-barr virus (ebv), the first human virus related to oncogenesis, was initially identified in a burkitt lymphoma cell line in 1964. ebv infects over 90% of the world's population. most infected people maintain an asymptomatic but persistent ebv infection lifelong. however, in some individuals, ebv infection has been involved in the development of cancer and autoimmune disease. nowadays, oncogenic potential of ebv has been intensively studied in a wide range of human neoplasms, including ho ... | 2015 | 26628948 |
| gammaherpesvirus infection of human neuronal cells. | gammaherpesviruses human herpesvirus 4 (hhv4) and hhv8 are two prominent members of the herpesvirus family associated with a number of human cancers. hhv4, also known as epstein-barr virus (ebv), a ubiquitous gammaherpesvirus prevalent in 90 to 95% of the human population, is clinically associated with various neurological diseases such as primary central nervous system lymphoma, multiple sclerosis, alzheimer's disease, cerebellar ataxia, and encephalitis. however, the possibility that ebv and k ... | 2015 | 26628726 |
| computed tomography findings for a gastric lymphoepithelioma-like carcinoma: how often does it present as a submucosal mass? | to describe the anatomical location, size, tumour characteristics and morphology on ct of gastric lymphoepithelioma-like carcinoma (lelc) in order to determine the proportion of lesions that present as submucosal masses, and to review the clinicopathological findings. | 2016 | 26628066 |
| seroprevalence of anti-ebv igg among various age groups from khon kaen province, thailand. | epstein-barr virus (ebv) is an extremely common herpesvirus that may cause asymptomatic infection or various diseases, including infectious mononucleosis, certain lymphoproliferative diseases and several types of neoplasms. vaccine development is an important strategy to reduce the burden of ebv-associated diseases and the timing of vaccinations should be before primary infection occurs. in the past, more than 90% of thai children were infected with ebv in early childhood. now, due to the improv ... | 2015 | 26625765 |
| the incubation period of primary epstein-barr virus infection: viral dynamics and immunologic events. | epstein-barr virus (ebv) is a human herpesvirus that causes acute infectious mononucleosis and is associated with cancer and autoimmune disease. while many studies have been performed examining acute disease in adults following primary infection, little is known about the virological and immunological events during ebv's lengthy 6 week incubation period owing to the challenge of collecting samples from this stage of infection. we conducted a prospective study in college students with special emp ... | 2015 | 26624012 |
| adult systemic epstein-barr virus-positive t-cell lymphoproliferative disease: a case report. | systemic epstein-barr virus (ebv)-positive t-cell lymphoproliferative disease (ebv(+) t-lpd) occurs mainly in asia and south america and is extremely rare in adults. the disease is characterized by a clonal proliferation of ebv-infected t cells with a cytotoxic immunophenotype and is associated with a poor clinical outcome and can be life-threatening. the majority of the patients have evidence of systemic disease, often with lymph node, liver and spleen involvement. the present study describes a ... | 2015 | 26622433 |
| epstein-barr virus infection involving bilateral middle cerebellar peduncles in an old woman: a case report. | 2016 | 26621363 | |
| simultaneously increased expression of microrna-155 and suppressor of cytokine signaling 1 (socs1) gene in the peripheral blood mononuclear cells of patients with primary sjögren's syndrome. | the microrna-155 (mir-155) is regarded as a central modulator of t-cell responses and could be a potential therapeutic target for certain inflammatory diseases. in our present study we analyzed the expression rate of mir-155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 (socs1) in primary sjögren's syndrome (pss). | 2015 | 26620207 |
| hpv infection, but not ebv or hhv-8 infection, is associated with salivary gland tumours. | benign and malignant salivary gland tumours are clinically heterogeneous and show different histology. little is known about the role of human herpes virus 8 (hhv-8), epstein-barr virus (ebv), and human papillomavirus (hpv) infection in salivary gland neoplasms. we investigated the presence of the three viruses in formalin-fixed, paraffin-embedded tissue samples in a cohort of 200 different salivary gland tumours. we performed ebv-lmp-1 and hhv-8 and p16 immunohistochemistry, a specific chip bas ... | 2015 | 26618178 |
| a case of gastric cancer with heterogeneous components of eb virus (+)/tp53 (+) and eb virus (-)/tp53 (-). | epstein-barr virus (ebv)-associated gastric adenocarcinoma is a histological subtype of gastric adenocarcinoma, in which all of the carcinoma cells are basically positive for ebv-encoded small rna (eber) by in situ hybridization. although its typical histology has some overlap with gastric carcinoma with lymphoid stroma, absence of massive lymphoid infiltrate is sometimes observed either in whole or in part. ebv-associated adenocarcinoma is one of the four representative molecular pathological s ... | 2015 | 26617924 |
| primary mucosal cd30-positive t-cell lymphoproliferative disorders of the head and neck rarely involving epiglottis: clinicopathological, immunohistomchemical and genetic features of a case. | a case of primary mucosal cd30-positive t-cell lymphoproliferative disorder of the head and neck rarely involving epiglottis in a 59-year-old male was reported. histologically, the ulcerative mucosa was affected by sheets of mixed inflammatory infiltration, with scattered large atypical lymphoid cells arranging in an individual or small clusters with focal epidermotropism. immunohistochemically, tumor cells were uniformly immunoreactive to antibodies against cd2, cd3, cd7, cd43, cd4, tia-1, with ... | 2015 | 26617911 |
| prognostic value of trop2 in human nasopharyngeal carcinoma. | there is increasing evidence demonstrating the role of human trophoblast cell surface antigen 2 (trop2) in cancer development and progression. however, their prognostic value in epstein-barr virus (ebv) associated nasopharyngeal carcinoma (npc) remains to be elucidated. | 2015 | 26617817 |
| genotypic detection of epstein barr virus in pediatric transplant recipients from india. | to determine the rate of occurrence and genotypes of epstein-barr virus (ebv) among pediatric renal and liver transplants recipients. | 2015 | 26615341 |
| effects of mtor and calcineurin inhibitors combined therapy in epstein-barr virus positive and negative burkitt lymphoma cells. | post-transplant lymphoproliferative disorder is a severe complication in solid organ transplant recipients, which is highly associated with epstein-barr virus infection in pediatric patients and occasionally presents as burkitt- or burkitt-like lymphoma. the mammalian target of rapamycin (mtor) pathway has been described as a possible antitumor target whose inhibition may influence lymphoma development and proliferation after pediatric transplantation. we treated epstein-barr virus positive (raj ... | 2016 | 26613512 |
| the first report of a previously undescribed ebv-negative nk-cell lymphoma of the gi tract presenting as chronic diarrhoea with eosinophilia. | a 74-year-old man presented with a 2-month history of watery diarrhoea. his complete blood count showed lymphopaenia and marked eosinophilia. investigations for common infectious causes including clostridium difficile toxin, stool culture, ova and parasites were negative. endoscopy revealed extensive colitis and a ct of the abdomen identified numerous large abdominal lymph nodes suspicious for lymphoma. multiple tissue samples were obtained; colon, mesenteric lymph node and bone marrow biopsy, a ... | 2015 | 26611482 |
| plasmablastic lymphoma presenting as a large intracardiac mass and bilateral pleural effusions. | plasmablastic lymphoma (pbl) is a rare aggressive lymphoma arising most frequently in the oral cavity of hiv-infected patients. rare cases of pbl have been reported in extra-oral sites, as well as in hiv-negative patients. cardiac involvement by lymphoma is very rare. the most common primary cardiac lymphoma is diffuse large b-cell lymphoma. we report an unusual case of pbl in a 49-year-old, hiv-positive man presenting with a large intracardiac mass and bilateral pleural effusions. histological ... | 2016 | 26607603 |
| the unexpected finding of a splenic infarction in a patient with infectious mononucleosis due to epstein-barr virus. | the authors present a case of a 24-year-old man with infectious mononucleosis (im) due to epstein-barr virus (ebv). among his symptoms, he reported abdominal pain in the upper left quadrant. an abdominal ultrasound and ct revealed an extensive splenic infarction. during the acute stage of this disease, the thrombophilic screening revealed reduced free protein s and elevated factor viii, with normalisation on re-evaluation 6 weeks later. splenic infarction is a very rare complication of im due to ... | 2015 | 26607191 |
| virus-specific cd8(+) t cells cross-reactive to donor-alloantigen are transiently present in the circulation of kidney transplant recipients infected with cmv and/or ebv. | t cells play a dual role in transplantation: they mediate transplant rejection and are crucial for virus control. memory t cells generated in response to pathogens can cross-react to alloantigen, a phenomenon called heterologous immunity. virus-specific cd8(+) t cells cross-reacting to donor-alloantigen might affect alloimmune responses and hamper tolerance induction following transplantation. here, we longitudinally studied these cross-reactive cells in peripheral blood of 25 kidney transplant ... | 2016 | 26603974 |
| splenic infarction in acute infectious mononucleosis. | the evaluation of a febrile patient with acute abdominal pain represents a frequent yet possibly challenging situation in the emergency department (ed). splenic infarction is an uncommon complication of infectious mononucleosis, and may have a wide range of clinical presentations, from dramatic to more subtle. its pathogenesis is still incompletely understood, yet it may be associated with the occurrence of transient prothrombotic factors. | 2016 | 26602427 |
| lymphoproliferative disorders in inflammatory bowel disease patients on immunosuppression: lessons from other inflammatory disorders. | immunosuppressive agents, such as thiopurines, methotrexate, and biologics, have revolutionized the treatment of inflammatory bowel disease (ibd). however, a number of case reports, case control studies and retrospective studies over the last decade have identified a concerning link between immunosuppression and lymphoproliferative disorders (lpds), the oncological phenomenon whereby lymphocytes divide uncontrollably. these lpds have been associated with epstein-barr virus (ebv) infection in whi ... | 2015 | 26600976 |
| transient widespread cortical and splenial lesions in acute encephalitis/encephalopathy associated with primary epstein-barr virus infection. | infection with epstein-barr virus (ebv) is very common and usually occurs in childhood or early adulthood. encephalitis/encephalopathy is an uncommon but serious neurological complication of ebv. a case of ebv-associated encephalitis/encephalopathy with involvement of reversible widespread cortical and splenial lesions is presented herein. an 8-year-old chinese girl who presented with fever and headache, followed by seizures and drowsiness, was admitted to the hospital. magnetic resonance imagin ... | 2016 | 26600186 |
| medullary carcinoma of the small bowel. | medullary carcinoma of the large bowel occurs mainly right-sided in elderly females. the tumour is almost invariably microsatellite instable and has been associated with favourable outcome. our study aimed to present three cases of medullary carcinoma originating from the small bowel. | 2016 | 26599717 |
| epstein-barr virus from burkitt lymphoma biopsies from africa and south america share novel lmp-1 promoter and gene variations. | epstein barr virus (ebv) sequence variation is thought to contribute to burkitt lymphoma (bl), but lack of data from primary bl tumors hampers efforts to test this hypothesis. we directly sequenced ebv from 12 bl biopsies from ghana, brazil, and argentina, aligned the obtained reads to the wild-type (wt) ebv reference sequence, and compared them with 100 published ebv genomes from normal and diseased people from around the world. the 12 bl ebvs were type 1. eleven clustered close to each other a ... | 2015 | 26593963 |
| oxidative stress enables epstein-barr virus-induced b-cell transformation by posttranscriptional regulation of viral and cellular growth-promoting factors. | infection of human b lymphocytes by epstein-barr virus (ebv) leads to the establishment of immortalized lymphoblastoid cell lines (lcls) that are widely used as a model of viral oncogenesis. an early consequence of infection is the induction of dna damage and activation of the dna damage response, which limits the efficiency of growth transformation. the cause of the dna damage remains poorly understood. we have addressed this question by comparing the response of b lymphocytes infected with ebv ... | 2016 | 26592445 |
| [development of taqman-based real-time pcr assay for detection of epstein-barr virus dna]. | epstein-barr virus (ebv) is a human herpesvirus which infects almost all of the world's population subclinically during childhood and thereafter remains for a life. immunocompromised persons often show active ebv infection, which may progress to virus-associated lymphoproliferative disorders. many clinical researches show a strong role for viral load measurement in predicting and monitoring ebv-associated diseases, especially in immunosuppressed patients. the aim of this work was to design and t ... | 2015 | 26591663 |
| the genomic sequence of lymphocryptovirus from cynomolgus macaque. | lymphocryptoviruses such as epstein-barr virus (ebv) cause persistent infections in human and non-human primates, and suppression of the immune system can increase the risk of lymphocryptovirus (lcv)-associated tumor development in both human and non-human primates. to enable lcv infection as a non-clinical model to study effects of therapeutics on ebv immunity, we determined the genomic dna sequence of the lcv from cynomolgus macaque, a species commonly used for non-clinical testing. comparison ... | 2016 | 26590795 |
| role of non-hepatotropic viruses in acute sporadic viral hepatitis and acute-on-chronic liver failure in adults. | acute viral hepatitis (avh) is mostly caused by hepatitis e (hev) and hepatitis a (hav) viruses in india. this study was undertaken to find out the incidence of various hepatotropic and non-hepatotropic viruses in avh and acute-on-chronic liver failure (aclf) patients. | 2015 | 26589230 |
| first case of primary intraocular natural killer t-cell lymphoma. | natural killer cell tumors can be broadly divided by origin into mature-cell and progenitor-cell types. the invasion of nasal-origin natural killer cells into the ophthalmologic field is sometimes observed in patients, but primary ocular natural killer cell tumors are a rare occurrence. | 2015 | 26585973 |
| interpreting the distinct and shared genetic characteristics between epstein-barr virus associated and non-associated gastric carcinoma. | gastric carcinoma is one of the major causes of cancer mortality worldwide. there is a better prognosis for patients with epstein-barr virus (ebv)-associated gastric carcinoma (ebvagc) compared with those with ebv negative gastric carcinoma (ebvngc). it is partly due to the fact that ebv infection recruits lymphocytes infiltrating the tumor. it has been reported that this infection indeed resulted in the changes in immune response genes and thus preventing the development of tumor. it is worthwh ... | 2016 | 26584536 |
| coprevalence of epstein-barr virus, cytomegalovirus, and herpes simplex virus type-1 antibodies among united states children and factors associated with their acquisition. | epstein-barr virus (ebv), cytomegalovirus (cmv), and herpes simplex virus type-1 (hsv-1) infections are common worldwide, but age-specific prevalence of primary infection varies by race or ethnicity and geographical location. comparing demographic groups could identify factors influencing the rate of acquisition, age-specific antibody prevalence is relevant for determining when to administer prophylactic vaccines, and coprevalence suggests similar risk factors. | 2015 | 26582871 |
| epstein-barr virus mimicking lymphoma--a case report. | a 50-year-old male without a relevant medical history came to the emergency department with fever, muscle pain and fatigue without any localising symptoms. blood and urine cultures remained negative. laboratory work- up showed elevated liver enzymes and lactate dehydrogenase; epstein-barr virus (ebv) serology was negative. additional imaging showed a splenomegaly and cervical, axillary, mediastinal and hilar lymphadenopathy. pathological examination of one of the lymph nodes and bone marrow biop ... | 2015 | 26582808 |
| epstein-barr virus microrna mir-bart20-5p suppresses lytic induction by inhibiting bad-mediated caspase-3-dependent apoptosis. | epstein-barr virus (ebv) is a human gammaherpesvirus associated with a variety of tumor types. ebv can establish latency or undergo lytic replication in host cells. in general, ebv remains latent in tumors and expresses a limited repertoire of latent proteins to avoid host immune surveillance. when the lytic cycle is triggered by some as-yet-unknown form of stimulation, lytic gene expression and progeny virus production commence. thus far, the exact mechanism of ebv latency maintenance and the i ... | 2015 | 26581978 |
| the role of latently infected b cells in cns autoimmunity. | the onset of multiple sclerosis (ms) is caused by both genetic and environmental factors. among the environmental factors, it is believed that previous infection with epstein-barr virus (ebv) may contribute in the development of ms. ebv has been associated with other autoimmune diseases, such as systemic lupus erythematous, and cancers like burkitt's lymphoma. ebv establishes a life-long latency in b cells with occasional reactivation of the virus throughout the individual's life. the role playe ... | 2015 | 26579121 |
| the genetic diversity of epstein-barr virus in the setting of transplantation relative to non-transplant settings: a feasibility study. | this study examines ebv strains from transplant patients and patients with im by sequencing major ebv genes. we also used ngs to detect ebv dna within total genomic dna, and to evaluate its genetic variation. sanger sequencing of major ebv genes was used to compare snvs from samples taken from transplant patients vs. patients with im. we sequenced ebv dna from a healthy ebv-seropositive individual on a hiseq 2000 instrument. data were mapped to the ebv reference genomes (ag876 and b95-8). the nu ... | 2016 | 26578436 |
| a young man presenting with pleuritic chest pain and fever after electrophysiological study and implantable cardioverter-defibrillator placement: diagnostic difficulties and value of bedside thoracic sonography. | we describe the case of a 23-year-old man presenting with recurrent pleuritic chest pain and prolonged fever after electrophysiology testing and placement of an implantable cardioverter-defibrillator because of a suspected arrhythmogenic right ventricular dysplasia. the clinical suspicion was initially directed toward pneumonia with pleural effusion and later toward an infection of the cardiac device complicated by septic pulmonary embolism. the definitive diagnosis of pulmonary embolism and inf ... | 2015 | 26576159 |
| prospective epstein-barr virus-related post-transplant lymphoproliferative disorder prevention program in pediatric allogeneic hematopoietic stem cell transplant: virological monitoring and first-line treatment. | in 28 pediatric allogeneic hematopoietic stem cell transplant (allo-hsct) recipients, we aimed to evaluate: (i) the impact of routine epstein-barr virus (ebv) dna monitoring on the development of ebv-related post-transplant lymphoproliferative disorder (ebv-ptld); (ii) the incidence of ebv infection and the potential risk factors; and (iii) the suitability of whole blood (wb) as clinical specimen to monitor the risk of patients to develop ebv-ptld. | 2016 | 26574232 |
| epstein-barr virus positivity, not mismatch repair-deficiency, is a favorable risk factor for lymph node metastasis in submucosa-invasive early gastric cancer. | epstein-barr virus (ebv)-associated gastric cancer (gc) and microsatellite-instability-high gc are associated with a low prevalence of regional lymph node metastasis (lnm). to evaluate the feasibility of endoscopic treatment of ebv-associated and/or microsatellite-instability-high early gc (egc), we analyzed the risk factors for lnm using a large series (n = 756) of submucosa-invasive (sm) egc. | 2016 | 26573601 |
| study of the frequency of herpesvirus infections among patients suspected aseptic meningitis in the west of iran. | aseptic meningitis is the most common type of meningitis and is characterized by meningeal inflammation that is not linked to identifiable bacterial pathogens in cerebrospinal fluid (csf). | 2015 | 26568804 |
| eb-virus latent membrane protein 1 potentiates the stemness of nasopharyngeal carcinoma via preferential activation of pi3k/akt pathway by a positive feedback loop. | our previous study reported that epstein-barr virus(ebv)-encoded latent membrane protein 1 (lmp1) could induce development of cd44(+/high) stem-like cells in nasopharyngeal carcinoma (npc). however, the molecular mechanisms that underlie modulation of cancer stem cells (cscs) in npc remain unclear. here, we show that lmp1 induced csc-like properties through promotion of the expression of epithelial-mesenchymal transition-like cellular markers and through alterations in differentiation markers. f ... | 2016 | 26568302 |
| multiple intestinal ulcers associated with primary epstein-barr virus infection in a patient with rheumatoid arthritis undergoing methotrexate therapy. | a 47-year-old woman with a 2-year history of rheumatoid arthritis (ra) undergoing methotrexate treatment developed a perforated ulcer in the ileum for which she underwent emergency surgery. a histological analysis of the extirpated specimen presented a possible epstein-barr virus (ebv) infection in the ulcerative lesion without a feature of lymphoproliferative disorder. interestingly, the patient's serological tests with a paired serum diagnosed a primary ebv infection. the present case emphasiz ... | 2015 | 26567997 |
| time-series analysis comparing the prevalence of antibodies against nine viral species found in umbilical cord blood in japan. | in this study, we investigated the prevalence of antibodies against 9 viral species found in umbilical cord blood from 561 neonates in 2013. serum igg antibodies against the following viruses were measured: herpes simplex virus (hsv), varicella-zoster virus (vzv), epstein-barr virus (ebv), cytomegalovirus (cmv), human herpesvirus 6 (hhv-6), measles virus (mv), rubella virus (rv), mumps virus (muv), and human parvovirus b19 (hpv b19). a survey questionnaire regarding past medical history and mate ... | 2016 | 26567842 |
| constitutive autophagy contributes to resistance to tp53-mediated apoptosis in epstein-barr virus-positive latency iii b-cell lymphoproliferations. | the epstein-barr virus (ebv) is associated with various lymphoproliferative disorders and lymphomas. we have previously demonstrated that treating wild-type tp53-expressing b cell lines with the tp53 pathway activator nutlin-3 induced apoptosis in ebv-negative and ebv-positive latency i cells whereas ebv-positive latency iii cells remained much more apoptosis-resistant. here, we report a constitutively high level of autophagy in these resistant cells which express high levels of the proautophagi ... | 2015 | 26565591 |
| neoadjuvant chemotherapy in locally advanced nasopharyngeal carcinoma: defining high-risk patients who may benefit before concurrent chemotherapy combined with intensity-modulated radiotherapy. | the purpose of this study was to create a prognostic model for distant metastasis in patients with locally advanced npc who accept concurrent chemotherapy combined with intensity-modulated radiotherapy (ccrt) to identify high-risk patients who may benefit from neoadjuvant chemotherapy (nact). a total of 881 patients with newly-diagnosed, non-disseminated, biopsy-proven locoregionally advanced npc were retrospectively reviewed; 411 (46.7%) accepted ccrt and 470 (53.3%) accepted nact followed by c ... | 2015 | 26564805 |
| novel treatment for early-stage nasal natural killer/t-cell lymphoma: intra-maxillary arterial infusion chemotherapy with concomitant radiotherapy. | nasal natural killer (nk)/t-cell lymphoma (nnktl) displays unusual clinicopathological features, and the prognosis is very poor, even in the early stages of the disease. for early stage nnktl, we have developed a novel chemoradiotherapy regimen incorporating arterial infusion chemotherapy, administered via the superficial temporal artery, in combination with radiotherapy. the novel arterial infusion regimen consists of ifosfamide, carboplatin, methotrexate, peplomycin, and etoposide (mpvic-p). f ... | 2015 | 26563973 |
| splenic rupture in infectious mononucleosis: a systematic review of published case reports. | infectious mononucleosis (im) is a common viral illness that predominantly causes sore throat, fever and cervical lymphadenopathy in adolescents and young adults. although usually a benign, self-limiting disease, it is associated with a small risk of splenic rupture, which can be life-threatening. it is common practice therefore to advise avoiding vigorous physical activity for at least 4-6 weeks, however this is not based on controlled trials or national guidelines. we reviewed published case r ... | 2016 | 26563483 |
| infectious agents associated with head and neck carcinomas. | in addition to traditional risk factors such as smoking habits and alcohol consumption, certain microbes also play an important role in the generation of head and neck carcinomas. infection with high-risk human papillomavirus types is strongly associated with the development of oropharyngeal carcinoma, and epstein-barr virus appears to be indispensable for the development of non-keratinizing squamous cell carcinoma of the nasopharynx. other viruses including torque teno virus and hepatitis c vir ... | 2016 | 26563307 |
| porphyromonas gingivalis and epstein-barr virus are associated with increased levels of visfatin in gingival crevicular fluid. | there is little clinical information on the relationship between periodontopathogens and visfatin. the purpose of this study is to determine visfatin levels in the gingival crevicular fluid (gcf) of healthy individuals and patients with periodontitis and to investigate the possible relationship between this adipokine and the presence and levels of porphyromonas gingivalis, prevotella intermedia, prevotella nigrescense, and epstein-barr virus (ebv). | 2016 | 26561994 |
| copy number variation in cep57l1 predisposes to congenital absence of bilateral acl and pcl ligaments. | absence of the anterior (acl) or posterior cruciate ligament (pcl) are rare congenital malformations that result in knee joint instability, with a prevalence of 1.7 per 100,000 live births and can be associated with other lower-limb abnormalities such as acl agnesia and absence of the menisci of the knee. while a few cases of absence of acl/pcl are reported in the literature, a number of large familial case series of related conditions such as acl agnesia suggest a potential underlying monogenic ... | 2015 | 26561035 |
| molecular approach to targeted therapy for multiple sclerosis. | the development and evolution of targeted therapy to any disease require the identification of targets amenable to treatment of patients. here the pathogenetic signalling systems involved in multiple sclerosis are scrutinised to locate nodes of deregulation and dysfunction in order to devise strategies of drug development for targeted intervention. oliogoclonal bands (ocb) are isoelectric focusing profiles of immunoglobulins synthesised in the central nervous system. ocbs enable the diagnosis of ... | 2016 | 26560895 |
| prognostic value of p16 expression in epstein-barr virus-positive nasopharyngeal carcinomas. | overexpression of p16 is associated with improved outcomes among patients with oropharyngeal carcinoma. however, its role in the outcomes of patients with nasopharyngeal cancer (npc) remains unclear. | 2016 | 26560893 |
| epstein-barr virus (ebv) tegument protein bglf2 promotes ebv reactivation through activation of the p38 mitogen-activated protein kinase. | epstein-barr virus (ebv) is a ubiquitous gammaherpesvirus associated with both b cell and epithelial cell malignancies. ebv infection of b cells triggers activation of several signaling pathways that are critical for cell survival, virus latency, and growth transformation. to identify ebv proteins important for regulating cell signaling, we used a proteomic approach to screen viral proteins for ap-1 and nf-κb promoter activity in ap-1- and nf-κb-luciferase reporter assays. we found that ebv bglf ... | 2015 | 26559845 |
| identification and characterization of the physiological gene targets of the essential lytic replicative epstein-barr virus sm protein. | epstein-barr virus (ebv) sm protein is an essential lytic cycle protein with multiple posttranscriptional mechanisms of action. sm binds rna and increases accumulation of specific ebv transcripts. previous studies using microarrays and pcr have shown that sm-null mutants fail to accumulate several lytic cycle mrnas and proteins at wild-type levels. however, the complete effect of sm on the ebv transcriptome has been incompletely characterized. here we precisely identify the effects of sm on all ... | 2015 | 26559842 |