Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| one-day regimen of valacyclovir for treatment of recurrent genital herpes simplex virus 2 infection. | to evaluate the efficacy of a 1-day course of valacyclovir in reducing the duration and severity of genital herpes recurrences and to measure the frequency of viral shedding episodes subsequent to antiviral therapy. | 2008 | 18362859 |
| evaluation of mixed infection cases with both herpes simplex virus types 1 and 2. | herpes simplex virus type 1 (hsv-1) is isolated principally from the upper half of the body innervated by the trigeminal ganglia whereas herpes simplex virus type 2 (hsv-2) is generally isolated from the lower half of the body innervated by the sacral ganglia. however, recent reports suggest that hsv-1 and hsv-2 can each infect both the upper and lower half of the body causing a variety of symptoms and there is a possibility that hsv-1 and hsv-2 infections can occur simultaneously with both caus ... | 2008 | 18360901 |
| genital ulcers and concomitant complaints in men attending a sexually transmitted infections clinic: implications for sexually transmitted infections management. | although genital herpes has emerged as the most common cause of genital ulcers in southern africa, treatment for herpes is not available routinely in the region. this study was performed to determine the etiology of genital ulcers in men in durban and assess other sexually transmitted infections-related symptoms, presentation, and treatment patterns in this group. | 2008 | 18356769 |
| from affected to infected? orphanhood and hiv risk among female adolescents in urban zimbabwe. | despite the 15 million children orphaned by aids, and fears of sexual vulnerability, little is known about the link between orphanhood and hiv risk. | 2008 | 18356606 |
| hiv-neutralizing immunoglobulin a and hiv-specific proliferation are independently associated with reduced hiv acquisition in kenyan sex workers. | hiv-neutralizing immunoglobulin a (iga) and hiv-specific cellular immunity have been described in highly exposed, persistently seronegative (heps) individuals, but well controlled studies have not been performed. we performed a prospective, nested case-control study to examine the association of genital iga and systemic cellular immune responses with subsequent hiv acquisition in high-risk kenyan female sex workers (fsws). | 2008 | 18356602 |
| aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-hiv-1 activity by increasing the virion density. | aqueous extracts from leaves of well known species of the lamiaceae family were examined for their potency to inhibit infection by human immunodeficiency virus type 1 (hiv-1). | 2008 | 18355409 |
| [zao "ekolab" enzyme immunoassay systems for the diagnosis of herpes simplex]. | the laboratory diagnosis of herpes has recently ranked among the most topical problems of modern public health care since the role of the above infection, as other torch-group infections, is constantly increasing in the development of maternal and infant diseases. for the laboratory diagnosis of herpes, zao "ekolab" has proposed the enzyme immunoassay systems "eia-hsv-1-igg", "eia-hsv-2-igg", and "eia-hsv-1,2-igm" that allow for making type-specific diagnosis of herpes and for determining the ch ... | 2008 | 18354919 |
| influence of sexual activity on cytomegalovirus seroprevalence in the united states, 1988-1994. | sexual and nonsexual transmission of cytomegalovirus (cmv) occurs, but the frequency of sexual transmission in the general population of the united states is unknown. | 2008 | 18354346 |
| hiv and stis in clients and female sex workers in mining regions of gejiu city, china. | to investigate hiv/sexually transmitted infections (stis) among female sex workers (fsws) and clients in a mining region of china. | 2008 | 18354344 |
| herpes simplex virus type 2 ul56 interacts with the ubiquitin ligase nedd4 and increases its ubiquitination. | the herpes simplex virus ul56 gene is conserved among most members of the alphaherpesvirinae family and plays a critical role in viral pathogenicity in vivo. the hsv-2 ul56 protein (ul56) is a c-terminally anchored type ii membrane protein that is predicted to be inserted into the virion envelope, leaving its n-terminal domain in the tegument. ul56 interacts with kif1a and ul11. here we report that ul56 also interacts with the ubiquitin ligase nedd4 and increases its ubiquitination. nedd4 was id ... | 2008 | 18353951 |
| phase i dose-escalation study of a monovalent heat shock protein 70-herpes simplex virus type 2 (hsv-2) peptide-based vaccine designed to prime or boost cd8 t-cell responses in hsv-naïve and hsv-2-infected subjects. | this was a phase i study to assess the safety, tolerability, and immunogenicity of escalating doses of ag-702, a noncovalent complex of an hla a*0201-restricted epitope in the glycoprotein b protein of herpes simplex virus type 2 (gb2) and truncated human constitutive heat shock protein 70. similar vaccines have been immunogenic in animals. three injections of 10 to 250 mug were administered intradermally to hla a*0201-bearing subjects who were either herpes simplex virus type 2 (hsv-2)-infected ... | 2008 | 18353920 |
| 6-azathymidine-4'-thionucleosides: synthesis and antiviral evaluation. | the synthesis of dideoxy-6-azathymidine 4'-thionucleoside 1-(2,3-dideoxy-4-thio-beta-d-erythro-pentofuranosyl)-(6-azathymidine) (2), and the l-nucleoside, 1-(4-thio-beta-l-erythro-pentofuranosyl)-(6-azathymidine) (3) and their evaluation against a wide panel of antiviral assays are described. the l-thionucleoside (3) was devoid of antiviral activity. the dideoxy-thionucleoside (2) was moderately active against vaccinia virus (vv) and the herpes simplex virus strains hsv-1 (strain kos) and hsv-2 ... | 2008 | 18341254 |
| acyclovir does not reduce risk of hiv infection. | 2008 | 18338945 | |
| effect of herpes simplex suppression on incidence of hiv among women in tanzania. | infection with herpes simplex virus type 2 (hsv-2) is associated with an increased risk of acquiring infection with the human immunodeficiency virus (hiv). this study tested the hypothesis that hsv-2 suppressive therapy reduces the risk of hiv acquisition. | 2008 | 18337596 |
| the in vitro anti-herpes simplex virus type-1 and type-2 activity of long dan xie gan tan, a prescription of traditional chinese medicine. | long dan xie gan tan (ldxgt), a decoction of radix gentianae for purging the pathogenic inflammation of the liver, is a widely used prescription among many in traditional chinese medicine. the prescription is primarily used to treat the disorders induced by damp-heat in the liver and the gall bladder. | 2008 | 18332627 |
| evaluation of real-time polymerase chain reaction assays for the detection of herpes simplex virus in swab specimens. | an in-house herpes simplex virus (hsv) real-time polymerase chain reaction (pcr) hydrolysis probe assay and three commercial real-time hsv assays were evaluated for the detection of hsv from genital, oral, ocular and dermal clinical samples. five hundred and sixty samples from patients displaying signs and symptoms of hsv infection were used to evaluate the in-house hsv assay. a representative 151 samples were processed using the artus hsv-1/2 tm pcr kit, smartcycler non-typing and smartcycler t ... | 2008 | 18322714 |
| improved performance of enzyme-linked immunosorbent assays and the effect of human immunodeficiency virus coinfection on the serologic detection of herpes simplex virus type 2 in rakai, uganda. | ugandan subjects (820) were tested by focus herpeselect enzyme-linked immunosorbent assay (elisa), kalon herpes simplex virus type 2 elisa, and biokit rapid test, and the results were compared to those of western blotting. higher-than-standard-index cutoff values gave optimal sensitivity and specificity. kalon elisa was the optimal assay when an index value of 1.5 was used (sensitivity, 91.7%; specificity, 92.4%). | 2008 | 18321879 |
| phenoxazine derivatives inactivate human cytomegalovirus, herpes simplex virus-1, and herpes simplex virus-2 in vitro. | we examined whether phenoxazine derivatives, 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3h-phenoxazine-3-one (phx-1), 3-amino-1,4alpha-dihydro-4alpha-8-dimethyl-2h-phenoxazine-2-one (phx-2), and 2-amino-phenoxazine-3-one (phx-3) may have antiviral activity against herpes family viruses: human cytomegalovirus (hcmv), herpes simplex virus type 1 (hsv-1), and herpes simplex virus type 2 (hsv-2). the antiviral activity was evaluated by the selectivity index (si), which is the ratio of 50% cytotoxic ... | 2008 | 18319567 |
| [clinical features of acute retinal necrosis at hokkaido university hospital]. | to study clinical features of acute retinal necrosis (arn) at hokkaido university hospital. | 2008 | 18318274 |
| [acute retinal necrosis--today, past and future]. | 2008 | 18318270 | |
| hiv transmission risk behavior among hiv-infected adults in uganda: results of a nationally representative survey. | evaluate factors associated with hiv transmission risk behavior among hiv-infected adults in uganda. | 2008 | 18317003 |
| deletion of the marek's disease virus ul41 gene (vhs) has no measurable effect on latency or pathogenesis. | marek's disease is an economically important disease of poultry and is caused by an alphaherpesvirus, marek's disease virus (mdv). the predicted protein product of the mdv ul41 open reading frame has significant protein sequence identity with the virion host shutoff (vhs) protein gene in other alphaherpesviruses. to determine whether the mdv ul41 gene functions as a vhs protein, we utilized a transient co-transfection assay and demonstrated that the mdv ul41 protein was as active in degrading rn ... | 2008 | 18311518 |
| herpes simplex virus co-infection-induced chlamydia trachomatis persistence is not mediated by any known persistence inducer or anti-chlamydial pathway. | several inducers of chlamydial persistence have been described, including interferon-gamma (ifn-gamma), ifn-alpha, ifn-beta, and tumour necrosis factor-alpha (tnf-alpha) exposure, and iron, amino acid or glucose deprivation. a tissue-culture model of chlamydia trachomatis/herpes simplex virus type-2 (hsv-2) co-infection indicates that viral co-infection stimulates the formation of persistent chlamydiae. this study was designed to ascertain whether co-infection-induced persistence is mediated by ... | 2008 | 18310043 |
| prevalence of human papillomavirus and herpes simplex virus type 2 infection in korean commercial sex workers. | in order to investigate the prevalence of sexually transmitted viruses such as human papillomavirus (hpv) and herpes simplex virus (hsv) in korean commercial sex workers (csws), we selected 188 csws (age range 20-44 years, median age 24 years) who regularly visited one public health center in seoul, korea. hpv genotypes were analyzed by using a hpv dna chip, and an enzyme-linked immunosorbent assay (elisa) was used to detect type-specific igg against hsv2 antibody identifying seropositivity for ... | 2008 | 18309283 |
| no association between maternal recurrent genital herpes in pregnancy and higher risk for congenital abnormalities. | to study the possible links between recurrent symptomatic genital herpes during pregnancy and risk for congenital abnormalities (cas). | 2008 | 18307068 |
| zosteriform herpes simplex. | herpes simplex virus (hsv) infection, though most commonly seen in the oral, perioral and genital areas, can occur anywhere on the body. after primary infection, hsv then establishes latency in sensory nerve ganglia and reactivates intermittently, precipitated by various factors. these reactivations may be recurrent and appear in a dermatomal distribution, mimicking herpes zoster, often leading to misdiagnosis if no confirmatory laboratory tests are carried out. we report a 65-year-old man who p ... | 2008 | 18301829 |
| no evidence of sexual transmission of kaposi's sarcoma herpes virus in a heterosexual south african population. | the transmission of kaposi's sarcoma herpes virus (kshv) in men who have sex with men is clearly associated with sexual risk factors, but evidence of heterosexual transmission of kshv is conflicting. | 2008 | 18301065 |
| hsv2 acute retinal necrosis: diagnosis and monitoring with quantitative polymerase chain reaction. | to describe a case of hsv2 acute retinal necrosis (arn) diagnosed and monitored with quantitative polymerase chain reaction (pcr) in ocular fluids. | 2009 | 18297242 |
| relative efficiency of polymerase chain reaction and enzyme-linked immunosorbant assay in determination of viral etiology in congenital cataract in infants. | perinatal viral infections of fetus are among the leading causes of congenital cataract and identifying the viral etiology is important. | 2008 | 18296799 |
| seroprevalences of herpes simplex virus type 2, five oncogenic human papillomaviruses, and chlamydia trachomatis in katowice, poland. | herpes simplex virus type 2 (hsv-2), human papillomaviruses (hpvs), and chlamydia trachomatis are the most common pathogens causing sexually transmitted infections (stis). there is limited information about the prevalences of these stis in poland. here, we estimated the occurrence of immunoglobulin g (igg) antibodies against hsv-2, hpv, and c. trachomatis in 199 blood donors and 110 patients of both genders attending an sti clinic in katowice in southern poland. the seroprevalences of hsv-2 were ... | 2008 | 18287578 |
| acute retinal necrosis secondary to herpes simplex virus type 2 with preexisting chorioretinal scarring. | acute retinal necrosis in children is a devastating disease that requires early diagnosis and treatment. the authors describe a rarely reported case of bilateral acute retinal necrosis in a child caused by neonatal herpes simplex virus type 2, where the presence of previous chorioretinal scarring made diagnosis challenging. | 2008 | 18286969 |
| prevalence of hiv, herpes simplex virus-2, and syphilis in male sex partners of pregnant women in peru. | sexually active heterosexual men may represent an important risk factor for hiv infection and sti transmission to their female partners and unborn children, though little is known about the prevalence of stis in this population. we sought to determine the prevalence of hiv, herpes simplex virus type 2 (hsv-2), and syphilis infection and associated risk behaviors among male sex partners of pregnant women in peru. | 2008 | 18284696 |
| [infection of cytomegalovirus and herpes simplex virus and morphology of the infected spermatogenic cells in infertile men]. | to study the infection of human cytomegalovirus (hcmv) and herpes simplex virus type ii (hsv-i) and the morphological characteristics of the infected spermatogenic cells in the semen of infertile men. | 2007 | 18284053 |
| rectal immunization generates protective immunity in the female genital tract against herpes simplex virus type 2 infection: relative importance of myeloid differentiation factor 88. | the present study was undertaken to examine the potential of rectal route of immunization for induction of protective immunity in the female genital tract against genital herpes infection in mice. a single rectal immunization of female c57bl/6 mice with live attenuated herpes simplex virus type 2 lacking thymidine kinase (hsv-2 tk-) was shown to confer hsv-specific cellular and humoral immune responses as well as protection against an otherwise lethal vaginal challenge with a virulent hsv-2 stra ... | 2008 | 18276020 |
| trichomonas vaginalis infection and human immunodeficiency virus acquisition in african women. | trichomoniasis vaginalis is the most common nonviral sexually transmitted infection (sti) worldwide, with a particularly high prevalence in regions of human immunodeficiency virus (hiv) endemicity. however, its impact as a cofactor for hiv acquisition is poorly understood. | 2008 | 18275275 |
| factors associated with the prevalence and incidence of trichomonas vaginalis infection among african american women in new york city who use drugs. | trichomoniasis vaginalis, the most prevalent nonviral sexually transmitted infection, is associated with negative reproductive outcomes and increased hiv transmission and may be overrepresented among african americans. | 2008 | 18275272 |
| fetal exposure to herpesviruses may be associated with pregnancy-induced hypertensive disorders and preterm birth in a caucasian population. | to investigate the role of fetal viral infection in the development of a range of adverse pregnancy outcomes (apos), including pregnancy-induced hypertensive disorders (pihd), antepartum haemorrhage (aph), birthweight <10th percentile (small for gestational age, sga) and preterm birth (ptb). | 2008 | 18271886 |
| population levels of psychological stress, herpesvirus reactivation and hiv. | nearly 40,000 americans are newly infected with human immunodeficiency virus (hiv) each year. recently, studies have demonstrated associations between group-level characteristics and the prevalence and incidence of hiv/acquired immune deficiency syndrome (aids) and other sexually transmitted diseases. two mechanisms previously posited to explain these associations are neighborhood effects on risk behaviors and social or institutional policies. in this paper, we hypothesize that adversity at the ... | 2010 | 18264753 |
| detection of type 2 herpes simplex virus in cells of spermatogenic epithelium in infected testes of guinea pigs. | we developed a model of herpetic orchitis in guinea pigs. intratesticular inoculation of type 2 herpes simplex virus suspension results in infection of the testicular spermatocytes and spermatides. the possibility of viral infection dissemination from infected into intact testis is proven. | 2007 | 18256757 |
| vaccines against human papillomaviruses--a major breakthrough in cancer prevention. | carcinoma of the cervix (cacer) is the second most frequent malignancy in women on a global scale. epidemiological studies carried out at the beginning of the second half of the 20th century showed that cacer was of infectious nature and that its agent was transmitted by sexual intercourse. for some 15 years, herpes simplex virus type 2 (hsv2), the genital herpes virus, was suspected to be the etiological agent. this hypothesis was disproved just in the time when the first convincing evidence th ... | 2007 | 18251226 |
| an important role for type iii interferon (ifn-lambda/il-28) in tlr-induced antiviral activity. | type iii ifns (ifn-lambda/il-28/29) are cytokines with type i ifn-like antiviral activities, which remain poorly characterized. we herein show that most cell types expressed both types i and iii ifns after tlr stimulation or virus infection, whereas the ability of cells to respond to ifn-lambda was restricted to a narrow subset of cells, including plasmacytoid dendritic cells and epithelial cells. to examine the role of type iii ifn in antiviral defense, we generated il-28ralpha-deficient mice. ... | 2008 | 18250457 |
| cutting edge: progesterone regulates ifn-alpha production by plasmacytoid dendritic cells. | use of the progesterone (pg) birth control depot medroxyprogesterone acetate (dmpa) increases a woman's risk for sexually transmitted infection with hiv or hsv-2 via unknown mechanisms. plasmacytoid dendritic cells (pdcs) are circulating and tissue-resident sentinels capable of making large quantities of ifn-alpha upon recognizing viruses through tlrs 7 and 9. in this study, we show that pg inhibits tlr9-induced ifn-alpha production by human and mouse pdcs and that dmpa impairs tlr9- and virus-i ... | 2008 | 18250406 |
| imaging findings of neonatal herpes simplex virus type 2 encephalitis. | the ct, mr, and diffusion-weighted initial and follow-up imaging findings in neonatal herpes simplex virus type 2 (hsv-2) encephalitis were assessed. | 2008 | 18246335 |
| amphipathic dna polymers are candidate vaginal microbicides and block herpes simplex virus binding, entry and viral gene expression. | amphipathic dna polymers are promising therapies for the prevention of hiv and genital herpes infections. recent studies on a panel of such compounds indicated potent activity against hiv binding and entry. this current study was conducted to explore the anti-herpes simplex virus (hsv) activity of the same panel of compounds and to determine their mechanism of activity. | 2007 | 18240855 |
| [detection of herpesvirus genome by multiplex polymerase chain reaction (pcr) and real-time pcr in ocular fluids of patients with acute retinal necrosis]. | the human herpesvirus (hhv) family consists of types 1 to 8 (hhv1-8). the purpose of this study was to investigate the detection of hhv dna, especially hsv1 (herpes simplex virus 1, hhv1), hsv2 (herpes simplex virus 2, hhv2), and vzv (varicella-zoster virus, hhv3) in ocular fluids of patients with acute retinal necrosis(arn). | 2008 | 18240601 |
| detection of herpes virus dna in post-operative thyroid tissue specimens of patients with autoimmune thyroid disease. | to demonstrate any differences in the detection of herpes simplex virus type 1 and 2, cytomegalovirus, human herpes virus type 6 and 7 dna from thyroid tissue blocks of patients with autoimmune thyroid disease and multi-nodular goiter and to propose few mechanisms, which could explain the possible role of herpesvirus infection in the development of thyroid autoimmune responses. | 2008 | 18240111 |
| herpes virus and ménière's disease. | the main goal of this study was to examine the vestibular ganglia from patients with intractable classic ménière's disease (md) for the presence or absence of dna from three neurotropic viruses herpes simplex virus 1 and 2 (hsv1, hsv2) and varicella zoster virus (vzv) and to investigate the hypothesis that md is associated with virus reactivation within scarpa's ganglion. | 2008 | 18235203 |
| selective ablation of virion host shutoff protein rnase activity attenuates herpes simplex virus 2 in mice. | the virion host shutoff (vhs) protein of herpes simplex virus (hsv) has endoribonuclease activity and rapidly reduces protein synthesis in infected cells through mrna degradation. herpes simplex virus 1 (hsv-1) and hsv-2 vhs mutants are highly attenuated in vivo, but replication and virulence are largely restored to hsv-2 vhs mutants in the absence of a type i interferon (ifn) response. the role of vhs in pathogenesis and the hindrance of the type i ifn response have classically been examined wi ... | 2008 | 18234805 |
| community-based study on seroprevalence of herpes simplex virus type 2 infection in new delhi. | to determine the seroprevalence of herpes simplex virus type 2 (hsv-2) in two urban communities in delhi and to correlate the presence of hsv-2 seroprevalence with sociodemographic profile, risk factors and presence of other reproductive tract infections (rtis). | 2008 | 18227595 |
| t regulatory cells contribute to the attenuated primary cd8+ and cd4+ t cell responses to herpes simplex virus type 2 in neonatal mice. | the first weeks of life are characterized by immune tolerance and increased susceptibility to intracellular pathogens. the neonatal adaptive response to hsv is attenuated compared with adult control models in humans and mice. t regulatory cells (tregs) control autoimmunity and excessive immune responses to infection. we therefore compared treg responses in the draining lymph nodes (ln) of hsv-infected neonatal and adult c57bl/6 mice with the effect of treg depletion/inactivation by anti-cd25 (pc ... | 2008 | 18209051 |
| substrate specificity of the herpes simplex virus type 2 ul13 protein kinase. | the ul13 protein kinase is conserved among many herpesviruses but hsv-2 ul13 specificity is not known. here, we found that hsv-2 ul13 is a phosphoprotein that autophosphorylates, and that serines within erk and cdc2 motifs were important for autophosphorylation but not for ul13 phosphorylation of exogenous substrates. hsv-2 ul13 phosphorylated a peptide also recognized by erk and cdc2. however, mutation of substrate residues critical for cdc2 or erk phosphorylation did not alter hsv-2 ul13 phosp ... | 2008 | 18207213 |
| rapid quantitative pcr assays for the simultaneous detection of herpes simplex virus, varicella zoster virus, cytomegalovirus, epstein-barr virus, and human herpesvirus 6 dna in blood and other clinical specimens. | rapid diagnosis of human herpesvirus primary infections or reactivations is facilitated by quantitative pcrs. quantitative pcr assays with a standard thermal cycling profile permitting simultaneous detection of herpes simplex virus (hsv), varicella zoster virus (vzv), cytomegalovirus (cmv), epstein-barr virus (ebv), and human herpesvirus 6 (hhv6) dna were developed and validated for diagnostic use. high specificity and sensitivity were achieved and the new pcr assays correlated well with commerc ... | 2008 | 18205230 |
| anti-cehv1 antibodies of two cynomolgus macaques cross-react with hsv2 but not hsv1 antigens in elisa. | the aim of the study was to compare the cross-reactivity of macaque anti-cehv1 antibodies with type 1 and type 2 human herpes simplex viruses (hsv1 and hsv2). | 2008 | 18199071 |
| identification of a herpes simplex labialis susceptibility region on human chromosome 21. | most of the united states population is infected with either herpes simplex virus type 1 (hsv-1), herpes simplex virus type 2, or both. reactivations of hsv-1 infection cause herpes simplex labialis (hsl; cold sores or fever blisters), which is the most common recurring viral infection in humans. | 2008 | 18199027 |
| herpes simplex virus type 1 infection: overview on relevant clinico-pathological features. | herpes simplex virus type 1 (hsv-1) is a nuclear replicating enveloped virus, usually acquired through direct contact with infected lesions or body fluids (typically saliva). the prevalence of hsv-1 infection increases progressively from childhood, the seroprevalence being inversely related to socioeconomic background. primary hsv-1 infections in children are either asymptomatic or following an incubation period of about 1 week gives rise to mucocutaneous vesicular eruptions. herpetic gingivosto ... | 2008 | 18197856 |
| herpes simplex virus type 2 acquisition during recent hiv infection does not influence plasma hiv levels. | we assessed the effect of herpes simplex virus type 2 (hsv-2) acquisition on the plasma hiv rna and cd4 cell levels among individuals with primary hiv infection using a retrospective cohort analysis. we studied 119 adult, antiretroviral-naive, recently hiv-infected men with a negative hsv-2-specific enzyme immunoassay (eia) result at enrollment. hsv-2 acquisition was determined by seroconversion on hsv-2 eia, confirmed by western blot analysis. ten men acquired hsv-2 infection a median of 1.3 ye ... | 2008 | 18197122 |
| epigallocatechin gallate inactivates clinical isolates of herpes simplex virus. | in the absence of a fully effective herpes simplex virus (hsv) vaccine, topical microbicides represent an important strategy for preventing hsv transmission. (-)-epigallocatechin gallate (egcg) (molecular weight, 458.4) is the primary catechin in green tea. the present study shows that egcg has greater anti-hsv activity than other green tea catechins and inactivates multiple clinical isolates of hsv type 1 (hsv-1) and hsv-2. egcg reduced hsv-2 titers by >or=1,000-fold in 10 to 20 min and reduced ... | 2008 | 18195068 |
| [herpes simplex virus meningitis in 11 patients]. | we reviewed retrospectively the demographic, clinical, biological characteristics and outcomes of 11 patients with hsv meningitis. | 2008 | 18191515 |
| herpes simplex: insights on pathogenesis and possible vaccines. | abstract herpes simplex viruses are evolutionarily ancient and ubiquitous. in the past 20 years, there has been increasing recognition of a worldwide pandemic of hsv-2 infection. moreover, hsv-2 prevalence has increased despite fairly widespread use of antiviral drugs for hsv. the success of hsv-1 and hsv-2 stems from latency within long-lived neurons and frequent mucocutaneous shedding. the generally mild medical consequences of hsv infection reflect a functional equilibrium between host and mi ... | 2008 | 18186706 |
| deltarr vaccination protects from ka-induced seizures and neuronal loss through icp10pk-mediated modulation of the neuronal-microglial axis. | ischemic brain injury and epilepsy are common neurodegenerative diseases caused by excitotoxicity. their pathogenesis includes microglial production of inflammatory cytokines. our studies were designed to examine whether a growth compromised hsv-2 mutant (delta rr) prevents excitotoxic injury through modulation of microglial responses by the anti-apoptotic hsv-2 protein icp10pk. eoc2 and eoc20 microglial cells, which are differentially activated, were infected with delta rr or the icp10pk delete ... | 2008 | 18179717 |
| cxcl9 and cxcl10 expression are critical for control of genital herpes simplex virus type 2 infection through mobilization of hsv-specific ctl and nk cells to the nervous system. | cxcl9 and cxcl10 mediate the recruitment of t lymphocytes and nk cells known to be important in viral surveillance. the relevance of cxcl10 in comparison to cxcl9 in response to genital hsv-2 infection was determined using mice deficient in cxcl9 (cxcl9-/-) and deficient in cxcl10 (cxcl10-/-) along with wild-type (wt) c57bl/6 mice. an increased sensitivity to infection was found in cxcl10-/- mice in comparison to cxcl9-/- or wt mice as determined by detection of hsv-2 in the cns at day 3 postinf ... | 2008 | 18178850 |
| no association between antepartum serologic and genital tract evidence of herpes simplex virus-2 coinfection and perinatal hiv-1 transmission. | the purpose of this study was to assess the risk of perinatal hiv-1 transmission in women who are coinfected with herpes simplex virus-2 (hsv-2). | 2008 | 18177832 |
| treating curable sexually transmitted infections to prevent hiv in africa: still an effective control strategy? | evidence regarding the effectiveness of sexually transmitted infection (sti) treatment for hiv prevention in africa is equivocal, leading some policy makers to question whether it should continue to be promoted for hiv control. we explore whether treating curable stis remains a cost-effective hiv control strategy in africa. | 2008 | 18176323 |
| frequency of acyclovir-resistant herpes simplex viruses isolated from the general immunocompetent population and patients with acquired immunodeficiency syndrome. | herpes simplex virus (hsv) infections are usually chronically recurrent in the normal population and represent a significant cause of morbidity in immunocompromised patients. acyclovir (acv) is widely used for the treatment and prophylaxis of hsv infections. the emergence of acv-resistant strains has been frequently reported as a result of long-term acv therapy. | 2007 | 18173520 |
| [a herpes simplex virus encephalitis case with no clinical response to acyclovir treatment]. | in spite of high rates of morbidity and mortality in herpes simplex virus (hsv) encephalitis, however, it is one of the exceptional viral infections with specific and effective therapy. in this report a hsv encephalitis case who was clinically unresponsive to acyclovir treatment, has been presented. an 11 months old girl patient has been brought to our clinic with the complaints of high fever and focal convulsions. analysis of cerebrospinal fluid (csf) revealed decreased glucose level and abunda ... | 2007 | 18173083 |
| maternal infection and risk of preeclampsia: systematic review and metaanalysis. | there are lingering questions regarding the association between maternal infection and preeclampsia. systematic review and metaanalysis was conducted of observational studies that examined the relationship between maternal infection and preeclampsia. forty-nine studies met the inclusion criteria. the risk of preeclampsia was increased in pregnant women with urinary tract infection (pooled odds ratio, 1.57; 95% ci, 1.45-1.70) and periodontal disease (pooled odds ratio, 1.76; 95% ci, 1.43-2.18). t ... | 2008 | 18166297 |
| disseminated herpes simplex type-2 (hsv-2) infection after solid-organ transplantation. | we report on three cases of severe disseminated herpes simplex type-2 (hsv-2) infection that occurred in two orthotopic liver-transplant (olt) and one renal-transplant patients. in two cases, i.e., in the olt patients, this was associated with hsv-2-related acute hepatitis. the rapid onset of iv acyclovir (acv) therapy led to recovery within 8-12 days. although rare, hsv-2-disseminated infection, in the context of organ transplantation may be life-threatening, but can be cured if acv therapy is ... | 2008 | 18165863 |
| herpes simplex virus type 2 seroprevalence in korea: rapid increase of hsv-2 seroprevalence in the 30s in the southern part. | to determine the characteristics of seroprevalence of herpes simplex virus type 2 (hsv-2) infection among korean people, a cross-sectional study was conducted on three groups in 2004. the three groups consisted of the general public who visited public health centers, commercial sex workers (csws), and human immunodeficiency virus (hiv)-infected persons. among the general public, hsv-2 seroprevalence rates for age under the 20s, in the 20s, 30s, 40s and the above 22.6%, 32.7% and 32.3%, respectiv ... | 2007 | 18162706 |
| [human papilloma virus infection in pregnant women with normal pap-smears, hpv oncogenity and risk factors]. | the process of carcinogenesis in both types of cervical carcinoma is dependent on the infection of oncogenic types of hpv. hpv infection could be diagnosed on the basis of whether or not the dna virus in present. in pregnant women the latent-persistent infection easily changes into its active form. this process is related to changes in immunological response and concentration of the hormones. | 2007 | 18159820 |
| predominance of herpes simplex virus type 1 from patients with genital herpes in nova scotia. | the epidemiology of genital herpes is changing with evidence to suggest an increasing incidence of herpes simplex virus type 1 (hsv-1) infections. the results of 6529 hsv genital cultures taken between april 1998 and december 2001 were reviewed. overall, hsv-1 was recovered more often than hsv-2; 1213 versus 1045. this trend was particularly striking in young women 30 years of age or less, in whom 70.8% of isolates were hsv-1. in men of the same age range, 45% of isolates were hsv-1. the proport ... | 2003 | 18159431 |
| the effect of daily valacyclovir suppression on herpes simplex virus type 2 viral shedding in hsv-2 seropositive subjects without a history of genital herpes. | a substantial number of hsv-2 seropositive individuals lack a history of clinically recognized genital herpes. these individuals can transmit disease during periods of asymptomatic viral shedding. the frequency of asymptomatic shedding and the efficacy of antiviral therapy in reducing shedding has not been assessed in this population. | 2008 | 18157071 |
| results from a hypothesis generating case-control study: herpes family viruses and schizophrenia among military personnel. | herpes family viruses can cause central nervous system inflammatory changes that can present with symptoms indistinguishable from schizophrenia and therefore are of interest in schizophrenia research. most existing studies of herpes viruses have used small populations and postdiagnosis specimens. as part of a larger research program, we conducted a hypothesis-generating case-control study of selected herpes virus antibodies among individuals discharged from the us military with schizophrenia and ... | 2008 | 18156638 |
| genital herpes in africa: time to rethink treatment. | 2007 | 18156037 | |
| genital herpes. | genital herpes is the main cause of genital ulcers worldwide; the prevalence of herpes simplex virus (hsv) type 2 infections in the general population ranges from 10% to 60%. most genital herpes is caused by hsv-2, although hsv-1 accounts for about half of new cases in developed countries. the risk of hiv acquisition is three times higher in people with hsv-2. neonatal herpes is an uncommon but serious complication of genital herpes. most genital hsv-2 infections are unrecognised and undiagnosed ... | 2007 | 18156035 |
| the role of toll-like receptor ligands/agonists in protection against genital hsv-2 infection. | control of virus replication initially depends on rapid activation of the innate immune responses. toll-like receptor (tlr) ligands are potent inducers of innate immunity against viral infections, including herpes simplex virus (hsv). hsv-2 is currently one of the most common sexually transmitted infections in developed nations and is becoming more prevalent in adolescents. hsv-2 infects the genital mucosa and is associated with an increased risk of obtaining other sexually transmitted infection ... | 2008 | 18154594 |
| population prevalence of reported and unreported hiv and related behaviors among the household adult population in new york city, 2004. | surveillance for hiv likely underestimates infection among the general population: 25% of us residents are estimated to be unaware of their hiv infection. | 2008 | 18097231 |
| maternal herpes simplex virus type 2 infection, syphilis and risk of intra-partum transmission of hiv-1: results of a case control study. | genital ulcer disease including that caused by herpes simplex virus type 2 (hsv-2) and syphilis facilitates sexual transmission of hiv-1. the effect of these infections on intra-partum mother-to-child-transmission (mtct) of hiv-1 is unknown. | 2008 | 18097221 |
| hla-a*0201-restricted cd8+ cytotoxic t lymphocyte epitopes identified from herpes simplex virus glycoprotein d. | evidence obtained from both animal models and humans suggests that t cells specific for hsv-1 and hsv-2 glycoprotein d (gd) contribute to protective immunity against herpes infection. however, knowledge of gd-specific human t cell responses is limited to cd4+ t cell epitopes, with no cd8+ t cell epitopes identified to date. in this study, we screened the hsv-1 gd amino acid sequence for hla-a*0201-restricted epitopes using several predictive computational algorithms and identified 10 high probab ... | 2008 | 18097044 |
| sexual and demographic determinants for herpes simplex virus type 2 among fishermen along lake victoria, kenya. | to determine the prevalence and correlates of herpes simplex virus type 2 (hsv-2) seropositivity among fishermen along the shores of lake victoria in kisumu district, kenya. | 2008 | 18096647 |
| comparison of electrical properties of viruses studied by ac capacitance scanning probe microscopy. | capacitances of five types of viruses, adenovirus type 5 (av5), herpes simplex virus type 1 (hsv1), simian virus 40 (sv40), vaccinia (mva), and cowpea mosaic virus (cpmv), were compared by ac capacitance scanning probe microscopy. this technique, using a pt-coated afm tip as an electrode to probe capacitance of materials between the tip and a bottom electrode, has been applied to study surface structures of semiconductors and polymers with nanometer spatial resolution; however, biological sample ... | 2008 | 18092777 |
| response to brown et al., 'incident and prevalent herpes simplex virus type 2 infection increases risk of hiv acquisition among women in uganda and zimbabwe'. | 2007 | 18090290 | |
| histone modifications associated with herpes simplex virus type 1 genomes during quiescence and following icp0-mediated de-repression. | in the current study, it was shown that repressed virus genomes in quiescently infected mrc5 cells adopt a repressed histone-associated structure marked by the enrichment of deacetylated histones at a wide variety of herpes simplex virus type 1 (hsv-1) promoters. in addition, it was shown that genome de-repression, mediated by hsv-2 superinfection or delivery of icp0 using a recombinant adenovirus vector, resulted in the enrichment of acetylated histones on hsv dna. these data indicate that icp0 ... | 2008 | 18089730 |
| part xiv. antiviral agents other than antiretrovirals: therapy for herpesvirus infections, viral hepatitis, and influenza. | the incidences of viral infectious diseases are increasing at an alarming rate in the us and worldwide. antiviral therapy is challenging because viruses subsume normal host cellular mechanisms for many functions, have rapid replication rates, have poor error scanning when reading genetic code, and undergo frequent drug target mutations. this article will focus on antiviral drugs and principles of treatment for infections due to herpes simplex viruses (hsv1 and hsv2), varicella zoster virus (vzv) ... | 2007 | 18085096 |
| neonatal cd8+ t cells are slow to develop into lytic effectors after hsv infection in vivo. | hsv is an important neonatal pathogen. we defined the kinetics of the primary ctl response to hsv-2 in vivo in neonatal mice. using a replication-defective hsv-2 virus, we demonstrate that neonates mount a primary hsv-specific ctl effector response in the draining ln, with delayed onset and shortened peak activity, in contrast to the rapid, strong response observed in adult mice. the shortened peak neonatal ctl response is independent of hsv dose and is associated with retarded cd8(+) t cell exp ... | 2008 | 18081035 |
| type-specific seroprevalence of herpes simplex virus type 2 and associated risk factors in middle-aged women from 6 countries: the iarc multicentric study. | to determine type-specific seroprevalence of herpes simplex viruses (hsv-1 and hsv-2) and hsv-2 risk factors. | 2007 | 18080353 |
| hiv rates and risk behaviors are low in the general population of men in southern india but high in alcohol venues: results from 2 probability surveys. | as the hiv epidemic continues to expand in india, empiric data are needed to determine the course of the epidemic for high-risk populations and the general population. | 2007 | 18077840 |
| discrimination of herpes simplex virus type 2 strains by nucleotide sequence variations. | we determined the polymorphous 400-bp regions in ul53, us1, and us4 for the discrimination of herpes simplex virus type 2 (hsv-2) strains. thirty-six hsv-2 clinical strains could be differentiated into 35 groups using these three regions and into 36 groups by additional analysis of three noncoding regions previously reported as polymorphous. | 2008 | 18077652 |
| cervical human papillomavirus (hpv) infection and hpv type 16 antibodies in south african women. | there is a high incidence of cervical cancer in south african women. no large studies to assess human papillomavirus virus (hpv) infection or hpv type 16 (hpv-16) exposure have occurred in the region, a requirement for policy making with regards to hpv screening and the introduction of vaccines. control women (n = 1,003) enrolled in a case control study of hormonal contraceptives and cervical cancer were tested for 27 cervical hpv types by reverse line blot analysis. the seroprevalence of hpv-16 ... | 2008 | 18077644 |
| use of commercial enzyme immunoassays to detect antibodies to the herpes simplex virus type 2 glycoprotein g in a low-risk population in hanoi, vietnam. | sera from 1,238 vietnamese women in hanoi were tested for herpes simplex virus type 2 (hsv-2). hsv-2 prevalence was 2.0%. the kalon and biokit assays showed significantly higher concordance to western blotting data than did the focus assay (p < 0.01). screening by focus and then retesting with kalon/biokit of positive samples can reduce falsely positive results significantly (p < 0.01). | 2008 | 18077617 |
| terpenoids and phenolics from plectranthus strigosus, bioactivity screening. | further studies on plectranthus sp. (lamiaceae) led to the isolation of terpenes and phenol esters from plectranthus strigosus benth. ent-16-kauren-19-ol (1), ent-16-kauren-19-oic acid (2), xylopic acid (3), xylopinic acid (4), hinokiol (5), 4 beta,6 beta-dihydroxy-1 alpha,5 beta(h)-guai-9-ene (6) 4 beta,6 beta-dihydroxy-1 alpha,5 beta(h)-guai-10(14)-ene (7), mixtures of hexacosan-1,26-diol and octacosan-1,28-diol ferulate diesters (8), of esters from ferulic acid and fatty alcohols (9) and of e ... | 2008 | 18075900 |
| neonatal herpes in herpes simplex virus type 2 and hiv-seropositive pregnant patients; the role of preventive measures in the absence of clinical disease of herpes. | there is very little knowledge about how herpes simplex virus (hsv) seropositivity of hiv-positive mothers could complicate the occurrence of neonatal herpetic disease, in the absence of genital ulcers, in this group of patients. we present a case of fatal disseminated neonatal herpes infection in a baby, born to a hiv-positive patient, and wish to discuss the potential need for changes in the management of this group of patients during pregnancy. disseminated hsv disease is a rare, yet serious ... | 2007 | 18073024 |
| comparative in vitro study on the anti-herpetic effect of phytochemically characterized aqueous and ethanolic extracts of salvia officinalis grown at two different locations. | aqueous and ethanolic extracts of salvia officinalis (lamiaceae) from two different locations (garden and swabian mountains) were examined in vitro on rc-37 cells for their antiviral activity against herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) using a plaque reduction assay. the 50% inhibitory concentrations (ic50) of the extracts for hsv plaque formation were determined in dose-response studies. all extracts tested revealed a high virucidal activity against free hsv-1 and hsv-2. the ... | 2008 | 18068963 |
| new pseudonucleosides containing chiral oxazolidin-2-ones and cyclosulfamides as aglycones: synthesis and antiviral evaluation. | a series of chiral cyclosulfamides and oxazolidinon-2-ones have been synthesized starting from aminoacids. regioselective substitution of these pseudopyrimidic heterocyles was carried out under mitsunobu conditions. best substitution results were obtained by preliminary deprotection of cyclosulfamides and their condensation with beta-d-ribofuranose. chiral oxazolidin-2-ones were coupled directly with d-ribofuranose. all compounds were tested against hsv-2, vv and sv viruses. two compounds 6b and ... | 2007 | 18066822 |
| characterization and susceptibility to antiviral agents of herpes simplex virus type 1 containing a unique thymidine kinase gene with an amber codon between the first and the second initiation codons. | a herpes simplex virus type 1 (hsv-1) containing a thymidine (tk) gene with an amber mutation at the 8th position counted from the first aug codon was isolated from a child with acute gingivostomatitis. the virus was predicted to express a mutant viral translated from the 2nd aug codon at the 46th amino acid position and consisting of 331 amino acids. the virus was as sensitive to acyclovir (acv), 5-bromovinyl-2'-deoxyuridine (bvdu), 1-beta-d-arabinofuranosyl-(e)-5-(2-bromovinyl)uracil (bvarau), ... | 2008 | 18066636 |
| in vitro evaluation of the antiviral effects of the homeopathic preparation gripp-heel on selected respiratory viruses. | gripp-heel is a homeopathic preparation frequently used in the treatment of respiratory viral infections such as various types of influenza and the common cold. the antiviral activity of gripp-heel was studied in vitro on human pathogenic enveloped and nonenveloped rna and dna viruses. before the antiviral assays, in vitro cytotoxicity of gripp-heel was determined with cells used for the infection experiments (hela, hep-2, mdck, bgm) as well as with mitogen-stimulated peripheral blood mononuclea ... | 2007 | 18066110 |
| antiviral and immunomodulatory effect of a lyophilized extract of capparis spinosa l. buds. | herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2) are common human pathogens that in particular cases can also cause severe problems especially in immunodeficient patients. the present paper reports the antiviral and immunomodulatory properties of a methanolic extract of c. spinosa buds (cap), rich in flavonoids, including several quercetin and kaempferol glycosides. in particular we have investigated whether the in vitro exposure of human peripheral blood mononuclear c ... | 2008 | 18058988 |
| synthesis and anti-hsv activity of new n1-acyclic c4 and c6-disubstituted pyrazolo[3,4-d]pyrimidine nucleosides. | several n(1)-(2-hydroxyethoxy)methyl, (4-hydroxybutyl) and (2,3-dihydroxy-1-propoxy)methyl-c(4),c(6)-disubstituted-1h-pyrozolo[3,4-d]pyrimidines were synthesized. some of them were evaluated against herpes simplex virus 1 and 2 replications in e(6)sm cells. | 2007 | 18058546 |
| new analogs of acyclovir substituted at the side chain. | a series of novel analogs of acyclovir, substituted with an alkyl (methyl, ethyl, n-butyl) or phenyl group at the positions 1', 4', and/or 5', has been obtained in a direct one-pot coupling reaction of guanosine and the respective 1,3-dioxolanes. the new acyclonucleosides were essentially inactive in antiviral (hsv, vv, vsv, hbv) evaluation in vitro. | 2007 | 18058508 |
| herpes simplex virus-2 and hiv among noninjecting drug users in new york city. | to examine the relationship between herpes simplex virus 2 (hsv-2) seroprevalence and human immunodeficiency virus (hiv) seroprevalence among noninjecting heroin and cocaine users in new york city. | 2007 | 18049425 |
| papanicolaou smears induce partial immunity against sexually transmitted viral infections. | in a case-control study of hormonal contraceptives and invasive cervical cancer, an unexpected finding was a substantial decline in the prevalence of high-risk human papillomavirus (hpv) infection according to the lifetime number of pap smears received. here we assess the risk of 3 sexually transmitted viral infections -- herpes simplex virus 2 (hsv2), hpv, and human immunodeficiency virus (hiv) 1 and 2 -- in relation to the lifetime receipt of pap smears. | 2007 | 18049186 |