Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| the role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3'-triiodothyronine generation in rats. | serum concentrations of t4, t3, and rt3 as well as liver and kidney 5'-deiodinase activity, have been examined in rats stressed by restraint. after immobilization, serum concentrations of t3 decreased significantly (6 hr, -33 +/- 1%; 8 h, -42 +/- 3%), while serum rt3 increased (6 h, +55 +/- 3%; 8 h, +75 +/- 5%). in the same or similarly treated animals, there was a time-dependent reduction in t4 5'-deiodinase activity in both liver (4 h, -23 +/- 2%; 8 h, -43 +/- 3%) and kidney (4 h, -18 +/- 1%; ... | 1987 | 3803308 |
| inherited congenital goiter in mice. | congenital goiter (cog), a new autosomal recessive mutation in mice, has been mapped to the central region of chromosome 15. young adult mutant mice are characterized by a reduced rate of growth, mild anemia, hypothyroidism, as indicated by significantly lower total serum t4 and t3, and elevated serum tsh. thyroids from mutant mice are hypertrophied, deficient in colloid, show a reduced accumulation of iodine that is partially susceptible to perchlorate ion discharge, have modestly elevated seru ... | 1987 | 3803305 |
| an analysis of the interrelationship of nuclear and plasma triiodothyronine in the sea lamprey, lake trout, and rat: evolutionary considerations. | we have studied the interrelationship of plasma and hepatic nuclear t3 in two lower vertebrates, lake trout and sea lamprey. specific nuclear t3-binding sites were observed in liver of both species. binding affinities for t3 and several analogs in lamprey and trout were similar to those in rat liver. the findings of identical sedimentation coefficients, stokes radii, and mol wt suggest a high degree of homology of the receptor molecule among these species. in lamprey ammocoete, both total (appro ... | 1987 | 3803297 |
| cell-mediated immunity in brazilian hemophilia patients. | the purpose of this study was to correlate the immunological features of healthy hemophiliac a patients treated with commercial cryoprecipitates with those who received factor viii concentrates associated or not with cryoprecipitates. the absolute number of total lymphocytes, t3, t4 and b lymphocytes did not differ for either group of patients or the controls. the number of t8 lymphocytes was higher in the group treated only with cryoprecipitates than for the controls. the t4/t8 lymphocyte ratio ... | 1986 | 3801725 |
| induction chemotherapy with cis-platinum and 5-fluorouracil for squamous cell carcinoma of the head and neck. | one hundred and eight patients with squamous cell carcinoma of the upper aerodigestive tract (uadt) (t3, t4, no-n3; 17% stage ii, 54% stage iii, 27% stage iv) were given three courses of chemotherapy before any local treatment. the regimen consisted of cis-platinum 100 mg m-2 on day 1 and 5-fluorouracil 1000 mg m-2 on days 2-6; drugs were administered by continuous infusion. the toxicity of this protocol was acceptable, as 82% of the patients were able to receive the initially scheduled drug dos ... | 1986 | 3801272 |
| a time-course study of hypothyroidism-induced hypotension: its relation to hypothermia. | dietary administration of propylthiouracil (0.2%) to male sprague-dawley rats for a period of 8 weeks induced hypothyroidism and hypotension in these animals. resting heart rate, body weight, colonic temperature and serum thyroxine (t4) were significantly lower in the treated hypothyroid rats than in the controls. time-course study indicates that the maximal depression of these parameters occurred about the eighth week of ptu treatment; except t4 level which declined abruptly about the second we ... | 1986 | 3800508 |
| histopathological characteristics predictive for growth of squamous cell carcinomas of the head and neck heterotransplanted to nude mice. | human tumours heterotransplanted to nude mice vary both with respect to take rate and the rate of tumour line establishment, according to their histological type and between primary and recurrent tumours. the acceptance rate of squamous cell carcinomas of the head and neck is also thought to vary, according to their degree of differentiation and their site of origin. this provided the basis of the present analysis of different tumour characteristics predicting growth of squamous cell carcinomas ... | 1986 | 3800324 |
| effect of fasting on thyroxine, 3,5,3'-triiodothyronine, and cortisol concentrations in serum of dogs. | the present study was designed to compare basal and stimulated concentrations of 3,5,3'-triiodothyronine (t3), thyroxine (t4), and cortisol in serum of dogs fasted 12 or 18 hours (to represent overnight fasting) or 24 or 36 hours (to represent prolonged inappetence) with those of dogs that were not fasted. twenty-five adult beagle bitches were allotted to 5 experimental fasting groups (0, 12, 18, 24, and 36 hours). blood samples for hormonal analyses were obtained 4, 3, 2, and 1 hour before food ... | 1986 | 3800108 |
| ligation of single-stranded oligodeoxyribonucleotides by t4 rna ligase. | despite its unique ability to ligate single-stranded dna molecules, t4 rna ligase has so far seen little use in molecular biology due to long reaction times, modest yields, and apparent inability to promote ligation of long oligodeoxyribonucleotides. we describe here a set of reaction conditions which dramatically shorten the reaction time and give reproducible 40 to 60% ligation of dna fragments of up to 40 bases in length. these improvements open promising new fields of application to t4 rna l ... | 1986 | 3799962 |
| 3,5,3'-triiodothyronine (t3) and 3,3',5'-triiodothyronine (rt3) synthesis in rats hosting the r3230ac mammary tumour. | generation of t3 and rt3 from t4 was studied in r3230ac mammary tumours grown in fischer 344 rats as well as in the liver and kidney of these tumour-bearing hosts. the primary objective of this study was to determine if reversion of t3 to rt3 synthesis occurs in this experimental tumour model and in organs remote from the tumour site. tumours, hepatic and renal homogenates were analyzed 14-16 days following tumour implantation for 5- and 5'-iodothyronine deiodinase activity using thyroxine as su ... | 1986 | 3797959 |
| triiodothyronine (t3) nuclear binding sites in human placenta and decidua. | we studied the binding of triiodothyronine (t3) to human placenta and decidua. although the placenta effectively blocks transfer of thyroxine (t4) and t3 it may itself be a thyroid hormone-dependent tissue and may specifically bind t3. a single class of high-affinity binding sites was found (ka 3.8 +/- 0.31 s.e.m., and 3.3 +/- 10(9) m-1) for both placenta and decidua. limited capacity was also observed, viz., 0.117 +/- 0.01 and 0.102 +/- 0.018 fmoles/microgram deoxyribonucleic acid (dna), respec ... | 1986 | 3797387 |
| the region of phage t4 genes 34, 33 and 59: primary structures and organization on the genome. | the product of gene 33 is essential for the regulation of late transcription and gene product 59 is required in recombination, dna repair and replication. the exact functions of both proteins are not known. restriction fragments spanning the genomic area of genes 33 and 59 have been cloned into phage m13 and a 4.9 kb nucleotide sequence has been determined. translation of the dna sequence predicted that gp33 contains 112 amino acids with a mol.wt. of 12.816 kd while gp59 is composed of 217 amino ... | 1986 | 3797242 |
| discrepancies between clinical and histopathologic diagnoses in t3 pyriform sinus cancer. | the various ways in which pyriform sinus cancer extends to laryngeal structures were analyzed by whole-organ serial-sectioning. the problems regarding vocal cord fixation (t3) by this cancer are discussed. this study found that vocal cord fixation in pyriform sinus cancer is due mainly to the involvement of the intrinsic laryngeal muscles and not to the involvement of the arytenoid cartilage or the cricoarytenoid joint. a tumor originating in the medial wall tends to extend medially and to invad ... | 1987 | 3796180 |
| effect of thymosin immunostimulation with and without corticosteroid immunosuppression on chimpanzee hepatitis b carriers. | carriers of hepatitis b surface antigen (hbsag) are at a high personal risk of developing chronic hepatitis, cirrhosis, and primary hepatocellular carcinoma, and they pose a potential health threat to others. accordingly, erradication of the carrier state is an important therapeutic goal. several categories of drugs have been evaluated for this purpose, with, at best, limited success. the immune stimulants constitute a drug group considered to have potential benefit, since altered cell-mediated ... | 1987 | 3794672 |
| thyroid hormone metabolism in thyroid disease as reflected by the ratio of serum triiodothyronine to thyroxine. | in 77 euthyroid subjects the mean ratio between serum triiodothyronine (s-t3) in nmol/l x 10(3) and serum thyroxine (s-t4) in nmol/l was 22.4 with a standard deviation of 4.3. the distribution of the ratio was close to gaussian. it was not changed in subjects under estrogen effect. the ratio was increased in hypothyroid subjects suggesting a mechanism preserving s-t3 better than s-t4 in thyroid failure. this mechanism seemed independent of tsh as the increasing s-t3/s-t4 ratio in primary hypothy ... | 1986 | 3794185 |
| a rat model of the 131i-induced changes in thyroid function. | thyrotoxic patients treated with iodine-131 (131i) often present with low thyroxine (t4), normal triiodothyronine (t3) and raised thyrotropin (tsh) concentrations in serum. we have developed a rat model of this low t4, raised tsh state. rats were injected with 50, 150 or 450 mu ci 131i. a dose of 50 mu ci 131i caused no significant effect on thyroid function, as assessed by serum parameters whereas both 150 mu ci and 450 mu ci 131i caused a significant fall in serum t4 concentration accompanied ... | 1986 | 3794182 |
| intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. | the effect of thyroxine (t4) and triiodothyronine (t3) on the expression of uncoupling protein (ucp) in rat brown adipose tissue (bat) has been examined. thyroidectomized rats have a threefold reduction in basal ucp levels. when exposed to cold, they become hypothermic and show a fivefold lower response of ucp than euthyroid controls. t3 augments the basal levels and the response of ucp and its mrna to cold in a dose-dependent manner. however, to normalize the response of ucp, t3 has to be given ... | 1987 | 3793928 |
| relationship between pituitary and other target organ responsiveness in hypothyroid patients receiving thyroxine replacement. | this study was undertaken to compare the sensitivity of the thyrotrophs to that of other tissues to t4 treatment in hypothyroid patients. to do so, we measured serum total and free thyroid hormones and tsh, in addition to several serum markers of peripheral tissue response to thyroid status, in 21 hypothyroid patients treated with 50-micrograms increments of t4 to a maximum of 200 micrograms daily (group i) and in 104 clinically euthyroid patients receiving a long term constant replacement dose ... | 1987 | 3793854 |
| the value of magnetic resonance imaging in treatment planning of nasopharyngeal carcinoma. | seven patients with ajcc stage t4 nasopharyngeal carcinoma underwent both computed tomographic (ct) and magnetic resonance (mr) examinations prior to radiation therapy treatment planning. lateral tumor extension into the infratemporal fossa was visualized by mr as less extensive in three cases than suggested by ct, as was inferior extension into the parapharyngeal soft tissues in three cases. mr clarified uncertainties on ct regarding involvement of the pontine cistern in three patients and of t ... | 1986 | 3793554 |
| chronobiologic quantification of nocturnal low-dose dopamine effect on circadian rhythms of thyroid-related hormones and prolactin (prl). | six clinically-healthy young men provided plasma samples every 30 min for 24 h (from 09:00-09:00 on 2 occasions. tsh, free t3 and free t4 were determined in the 30-min samples, while prolactin was determined in samples 1-3h apart. during the first test span, each man received an infusion of physiologic saline between 21(00)-01(00). upon re-sampling several weeks later, 3 men received a low dose of dopamine (0.1 microgram/kg/min) and 3 men received a high dose (1.0 microgram) over the same hours ... | 1986 | 3792121 |
| serum iodothyronine concentrations during introduction of thyroxine replacement therapy in hypothyroidism. | serum concentrations of total and free t4 (tt4 and ft4), total and free t3 (tt3 and ft3), rt3, t4 binding globulin (tbg), t3 uptake (t3u) and tsh were measured in 12 patients with severe hypothyroidism before and during the introduction of replacement therapy with oral t4. the dose of t4 was increased by increments of 50 micrograms at intervals of 4 weeks to a total of 200 micrograms daily. there was a linear correlation between the concentrations of ft3 and ft4 (ft3 = 1.35 + 0.23ft4, r = 0.916, ... | 1986 | 3791670 |
| prolonged treatment of hyperthyroidism with sodium tyropanoate, an oral cholecystographic agent: a re-evaluation of its clinical utility. | to re-evaluate the clinical utility of the prolonged management of hyperthyroidism with sodium tyropanoate (tp), an oral cholecystographic agent, we studied the changes in the scoring of thyrotoxic signs and symptoms (thyrotoxic index; ti), serum concentrations and binding of thyroid hormone, and circulating tsh receptor antibodies (trab) in two groups of patients with graves' disease; seven patients (tp group) received tp (1.5 g daily) alone for 14 weeks, and six patients (tp + mmi group) recei ... | 1986 | 3791669 |
| assessment of thyroxine suppression in thyroid carcinoma patients with a sensitive immunoradiometric tsh assay. | serum tsh was determined with a sensitive radioimmunometric method (tsh irma) in 57 patients on suppression therapy with t4 after operation for differentiated thyroid carcinoma. when using a conventional ria technique basal tsh was not detectable and remained so even after stimulation with trh. with the tsh irma method 46 patients had a basal tsh below the detection limit (0.02 mu/l) (81%) and in seven patients the values were between 0.02 and 0.05 mu/l (12%). in 23 of these patients there was a ... | 1986 | 3791667 |
| the electroencephalographic pattern during electroconvulsive therapy. iv. spectral energy distributions with methohexital, innovar and ketamine anesthesias. | during phase iii of nondominant unilateral ect seizures, total energy, total peak energy, total delta energy, and 1/2-power duration of total delta energy are all less (shorter) in the unstimulated, dominant hemisphere than they are in the stimulated hemisphere. interhemispheric differences in total energy are greatest in the lateral frontotemporal cortex, where they average 40 percent with both methohexital and ketamine anesthesias in f8 greater than f7 and t4 greater than t3. this circumstance ... | 1986 | 3791648 |
| two domains for splicing in the intron of the phage t4 thymidylate synthase (td) gene established by nondirected mutagenesis. | of 97 nondirected t4 thymidylate synthase-defective (td) mutations, 27 were mapped to the intron of the split td gene. clustering of these intron mutations defined two domains that are functional in splicing, each within approximately 220 residues of the respective splice sites. two selected mutations, tdn57 and tdn47, fell within phylogenetically conserved pairings, with tdn57 disrupting the exon i-internal guide pairing (p1) in the 5' domain and tdn47 destabilizing the p9 helix in the 3' domai ... | 1987 | 3791415 |
| a constant current peripheral nerve stimulator (neurostim t4). description, and evaluation in volunteers. | a pocket-size, battery-powered peripheral nerve stimulator featuring a calibrated constant current floating output (max. 80 ma) was evaluated in unanaesthetized volunteers. modes of stimulation included continuous 1 hz, continuous train-of-four every 15 s, and on-demand tetanus (50 hz per 5 s). within the limits of 0-250 v, voltage adjusted automatically for 0.2-ms monophasic square pulses. between 20 and 80 ma, the dial error of current intensity was less than +/- 5%. maximum allowable resistan ... | 1986 | 3790397 |
| [studies on the enhancement of anti-tumor activity in patients with cervical cancer by local administration of ok-432]. | in order to investigate an effective administration method for ok-432, a potent biological response modifier (brm), in patients with cervical cancer, preoperative local administration was conducted and the following results obtained: immunohistochemical examination using monoclonal antibodies indicated that the group given local injection of ok-432 showed a marked increase in ia antigen-positive t4 cells, ia antigen-positive macrophages and nk cells in the tissue of the area surrounding the cerv ... | 1986 | 3789753 |
| the in situ cellular immune response in acute herpes simplex encephalitis. | to characterize the in situ cellular immune response in acute herpes simplex encephalitis (hse), the authors stained frozen brain specimens from 19 patients with hse and 8 controls with a panel of monoclonal antibodies, which allowed them to identify inflammatory cell subsets and expression of activation markers and major histocompatibility complex (mhc) molecules. parenchymal and meningeal inflammatory infiltrates were composed of t cells, with fewer natural killer and b cells, and variable num ... | 1986 | 3789090 |
| the role of radiation therapy in squamous cell carcinoma of the upper aerodigestive tract with positive surgical margins. | one hundred four patients with squamous cell carcinoma of the upper aerodigestive tract and with histologically positive surgical margins were evaluated for this historically controlled study to determine the efficacy of postoperative radiation therapy. positive margins were defined as the presence of one or more of the following: carcinoma in situ, tumor within 0.5 cm from the surgical margins, microscopic disease, or dysplasia. patients received either surgery alone (44 cases) or surgery plus ... | 1986 | 3788851 |
| thyroid function in a cassava-eating population affected by epidemic spastic paraparesis. | thyroid function was studied in a rural population in mozambique that had been affected by an epidemic of spastic paraparesis attributed to dietary cyanide exposure from cassava. laboratory investigation on a sample of this population demonstrated very high levels of serum and urinary thiocyanate, indicating a heavy exposure to cyanide. the urinary excretion of iodine was within normal limits, indicating an adequate intake of iodine. the serum levels of ft4i were somewhat decreased and serum ft3 ... | 1986 | 3788422 |
| hla-dr3 and drw6: prognostic factors for the incidence of hypothyroidism in graves' disease after radioiodine treatment. | several studies demonstrated a relationship between hla-b8 and -dr3 and the early course of thyroid function after treatment of thyrotoxicosis. however, the association between certain dr antigens and the outcome of thyroid function years after radioiodine treatment for graves' disease remains unclear. we therefore determined the hla pattern in 2 groups of female patients with different severity of hypothyroidism. from a total of 45 patients, 27 had developed pre-clinical hypothyroidism (normal ... | 1986 | 3788412 |
| effect of dietary cadmium intake on serum thyroxine and triiodothyronine concentrations in rhesus monkeys. | circulating thyroxine (t4) and triiodothyronine (t3) concentrations in rhesus monkeys were determined after various periods of cadmium administration in diet. no significant change in serum t4 and t3 levels was observed after 2 months of cadmium treatment. however, cadmium treatment for 4 months and 6 months showed a significant decrease in serum t4 and t3 levels indicating the adverse effect of long-term cadmium intake which increased gradually with duration of treatment. | 1986 | 3787667 |
| testosterone enhancement of thyroid carcinoma in rats: the role of tsh. | radiation treatment of long-evans male rats (40 mu ci na131i at the age of 2 months) led to a high incidence of thyroid follicular carcinomas at the age of 24 months; castration of males before irradiation caused a significant reduction in incidence of this tumor. in this study, replacement testosterone (t) was administered to castrated male rats by means of implanted, slow-release hormone-containing pellets (t-physiologic dose). three testosterone doses (0.1t, 1.0t, and 30t) were used to treat ... | 1986 | 3787463 |
| [serum concentration of t3, t4, ft3, ft4, tsh during cycloergometer muscular exercise]. | the serum concentrations of total and free thyroid hormones and of tsh have been determined in 10 trained subjects before, during and after exercise on a bicycle ergometer. the concentrations of t4 and ft4 increase during the muscular exercise and reduce 30 minutes after the end of work; the decrease is statistically meaningful for the t4. the concentrations of tsh and t3 reduce 30 minutes after the end of work on a bicycle ergometer. the serum concentration of ft3 and of hematocrit doesn't pres ... | 1986 | 3786666 |
| [intrathyroid deiodination of thyroxine: the effect of thyrotropic hormone and denervation of the thyroid]. | intrathyroid transformation of thyroxin (t4) into triiodothyronine (t3) and the role of thyrotropic hormone and denervation in this process were studied with in vivo blood perfusion of dog thyroid gland in situ and at 37 degrees c. both labelled 125i-t4 (200,000 imp/min) and nonlabeled t4 (1000 ng) were administrated in the arteries of thyroid lobules in situ and in a constant-temperature cabinet. enhanced excretion of triiodothyronine (both labeled and nonlabeled) observed two hours after the i ... | 1986 | 3786311 |
| the effect of dodecyl sulfate on immunoglobulin hapten binding. | the instantaneous effect of dodecyl sulfate (dds), in the mm concn range, on the binding of monovalent hapten by immunoglobulin was examined. fluorescence measurements were utilized to study the effect of the detergent on sheep antiserum generated against thyroxin (t4) and against methamphetamine. haptens were conjugated with the thiocyanate derivative of fluorescein in order to determine hapten binding on the basis of increased fluorescence polarization for the fluorescein-thiocarbamyl-hapten a ... | 1986 | 3785231 |
| [results of several combination modalities for maxillary cancer]. | two hundred forty-six patients with the histologically proved squamous cell carcinoma of the maxillary sinus were treated at the department of radiology, national sapporo hospital, with various combined modes of surgery, irradiation and chemotherapy. four combination modalities were used from 1966 to 1983. one hundred sixty-three (66.3%) patients were men and 83 (33.7%) were women. five-year survival was 41.0% in t2 (16 cases), 22.3% in t3 (176 cases) and 15% in t4 (53 cases). in 72 cases treate ... | 1986 | 3783974 |
| [relationship between tnm-classification and survival rate in cases of carcinoma of the oral cavity: a comparison between uicc and ajcc tnm staging systems]. | we compared tnm classification between uicc and ajcc in the case of oral cancer. t4 definition of uicc was indistinct and ajcc seemed better for t-classification. n-classification of ajcc was rational, since it distinguished between "solitary" and "multiple" nodes. it was inappropriate to equalize t3n0 for t3n1 in stage grouping and also to regard t4n0 as stage iv because t4n0 had better prognosis than t3n1. five-year survival rates of all cases were as follows. tongue (66.7%), floor of mouth (6 ... | 1986 | 3783963 |
| the bacteriophage t4 regulatory protein gpunf/alc binds to dna in the absence of rna polymerase. | dna-cellulose chromatography and two-dimensional gel electrophoresis have been used to demonstrate the dna-binding capacity of bacteriophage t4 gpunf/alc. the unf/alc protein does not bind to dna via an association with rna polymerase; gpunf/alc was shown to bind to dna after separation from rna polymerase and other large proteins by sephadex chromatography. | 1986 | 3783815 |
| the effect of orally administered melatonin on the seasonality of deer pelage exchange, antler development, lh, fsh, prolactin, testosterone, t3, t4, cortisol and alkaline phosphatase. | five milligrams of melatonin (m) per day was administered orally to four male white-tailed deer on a schedule that mimicked first decreasing and then increasing lengths of natural photoperiod. the following seasonal phenotypic and hormonal responses were observed: pelage exchange, antler mineralization, velvet shedding, and rutting behavior of experimental animals were advanced by 50-55 days. prolactin (prl) levels exhibited a bimodal curve with peaks in may and august, as compared to a monomoda ... | 1986 | 3783416 |
| detection of congenital hypopituitary hypothyroidism: ten-year experience in the northwest regional screening program. | we examined the results of the northwest regional screening program (nwrsp) over its first 10 years to determine whether the detection of hypopituitary hypothyroidism is a justified advantage of the primary thyroxine (t4)-supplemental thyroid-stimulating hormone (tsh) screening strategy, and to determine whether all such infants will be detected by this screening approach. between may 1975 and may 1985, the nwrsp screened 850,431 infants, detecting 192 infants with primary hypothyroidism (1:4429 ... | 1986 | 3783339 |
| bacteriophage t3 gene 8 product oligomer structure. | the structure of the connector of bacteriophage t3 (built up by the product of gene 8) has been studied in two dimensions by combined use of translational and rotational image filtering procedures applied to tetragonal ordered aggregates of the former oligomers. this analysis, performed up to 1/1.6 nm-1 resolution, has revealed the existence of a 12-fold symmetry in the outermost region of the specimen (mainly between radii 5.2 and 6.7 nm), a 6-fold one in the inner region (between radii 1.7 and ... | 1986 | 3782924 |
| serum free thyroid hormones in subclinical hypothyroidism. | serum free thyroxine (ft4) and free triiodothyronine (ft3) concentrations were measured in a group of 52 patients with subclinical hypothyroidism (sh) and in an equal group of age and sex-matched normal controls. sh was defined by normal total t4 (tt4) and total t3 (tt3) concentrations, normal ft4 and ft3 indices, raised tsh levels, in the absence of signs and symptoms of hypothyroidism. serum ft4 levels averaged 6.1 +/- 1.6 pg/ml (mean +/- sd, p less than 0.001 vs controls), with values below l ... | 1986 | 3782745 |
| development of thyroid function between vi-ix month of fetal life in humans. | well-preserved thyroid glands from 28 fetuses 22-34 weeks of gestational age and from 4 term newborns who survived at most 12 days were examined to study thyroid development in late intrauterine life. total iodine thyroglobulin (tg), t4, t3 and rt3 were assayed before and after hydrolysis with pronase. in the same maternity unit the cord-serum of 25 healthy term newborns was also assayed and the urine iodine on the day of delivery was tested in 52 newborns and their mothers. results are expresse ... | 1986 | 3782742 |
| hyperthyroidism in the elderly. | it is not uncommon for thyrotoxicosis to appear in an atypical manner in older patients. the classical symptoms are often absent. the disease is frequently characterized by cardiac, gastrointestinal, neuromuscular, and neuropsychiatric symptoms. as hyperthyroidism is readily amenable to effective treatment that can improve the quality of life, the clinical suspicion of this disease is always indicated and exclusion of this diagnosis should always be pursued. recognizing the admittedly great diff ... | 1986 | 3782702 |
| normalized noise energy as an acoustic measure to evaluate pathologic voice. | in order to evaluate noise components included in pathologic voice signals, a novel acoustic measure, normalized noise energy (nne), is proposed and its effectiveness for the detection of laryngeal pathologies is investigated with 250 vowel samples spoken by 64 control (normal) subjects and 186 patients with various laryngeal diseases. the nne is automatically computed from the voice signals using an adaptive comb filtering method performed in the frequency domain. experiments with the voice sam ... | 1986 | 3782609 |
| treatment of neonatal hyperthyroidism due to graves' disease with sodium ipodate. | we describe the effect of administration of repeated doses of sodium ipodate in a newborn infant with hyperthyroidism due to transient graves' disease. pretreatment (day 3) serum t4 and t3 concentrations were 49 micrograms/dl and 590 ng/dl, respectively. with 24 h after the first dose of ipodate, serum t3 fell by 40%, and it subsequently ranged from 209-278 ng/dl throughout the 39-day ipodate treatment period. serum t4 also decreased after ipodate administration to 69% and 41% of the pretreatmen ... | 1987 | 3782427 |
| effect of free fatty acids on the concentration of free thyroxine in human serum: the role of albumin. | the concentration of ffa in normal human plasma in vivo generally ranges between 0.2 and 0.7 meq/liter; slightly higher concentrations have occasionally been reported in patients who are seriously ill. to determine whether such ffa concentrations may increase the concentration of free t4 in serum, we added increasing amounts of oleic acid to pooled normal human serum (with known ffa content) and measured free t4 by equilibrium dialysis. total ffa up to 3 meq/liter in normal serum, representing a ... | 1986 | 3782424 |
| molecular proof that bacteriophage t4 alc and unf genes are the same gene. | the dna of bacteriophage t4 normally has a substituted base, hydroxymethylcytosine, instead of the usual cytosine. the bacteriophage shuts off host transcription after infection presumably by specifically blocking transcription of cytosine dna. if t4 incorporates cytosine into its own dna, this shutoff mechanism is directed back at itself and blocks its own transcription. mutations which overcome this transcriptional block are in the t4 alc gene, and alc mutations allow the propagation of t4 wit ... | 1986 | 3782028 |
| s-t4 and s-t3 levels during the l-thyroxine suppression test. | 1986 | 3781481 | |
| presence of random single-strand gaps in mycobacteriophage i3 dna. | the genomic double-stranded dna of mycobacteriophage i3, when denatured with alkali, heat, formamide or dimethylsulfoxide, breaks down to heterogeneous-sized single-strand (ss) fragments smaller than the expected intact unit genome length suggesting the presence of random ss interruptions on both the strands. the occurrence of the interruptions at random is also demonstrated by two-dimensional gel electrophoresis of the restriction fragments of i3 dna. these interruptions have no adverse effect ... | 1986 | 3781246 |
| the endocrine control of reproduction and molt in male and female emperor (aptenodytes forsteri) and adelie (pygoscelis adeliae) penguins. ii. annual changes in plasma levels of thyroxine and triiodothyronine. | changes in plasma thyroxine (t4) and triiodothyronine (t3) levels were studied during a breeding season and in more detail during the postbreeding molt in male and female emperor (aptenodytes forsteri) and adelie (pygoscelis adeliae) penguins under natural conditions in the antarctic. during the 4-month natural fast that accompanies courtship and incubation in male emperors, plasma t4 and t3 levels were maintained around 11 and 0.6 ng/ml, respectively. in courting, fasting female emperors plasma ... | 1986 | 3781233 |
| in vitro release of triiodothyronine and thyroxine from thyroid glands of the domestic fowl (gallus domesticus). | basal and thyrotrophin (tsh)-stimulated release of iodothyronines (triiodothyronine, t3, and thyroxine, t4) from intact chicken thyroid glands was determined in vitro. in the absence of tsh, t3 and t4 were released in measurable amounts in the incubation media. the release of both iodothyronines was directly related to the media tsh concentrations and incubation period. lineweaver-burke analysis revealed that the vmax for t3 was 99.4 pg/gland, with an apparent km of 17.8 mu tsh, and that the vma ... | 1986 | 3781229 |
| [changes in plasma fibronectin levels in patients with thyroid disease and its mechanism]. | plasma fibronectin (fn) level was determined in normal subjects and patients with thyroid disease by the laurell method. in vitro effect of triiodothyronine (t3) on fn synthesis by cultured human fetal skin fibroblasts was also studied. plasma fn level was 32.2 +/- 5.5 mg/dl (mean +/- sd) in normal adults, and no sex difference was observed. the plasma fn concentrations were increased in patients with hyperthyroidism (63.3 +/- 15.2 mg/dl), decreased in patients with hypothyroidism (19.5 +/- 6.5 ... | 1986 | 3781067 |
| thyroid function in insulin-dependent diabetic children. | serum concentrations of thyroxine (t4),3,5,3'-triiodothyronine (t3),3,3',5'-reverse triiodothyronine (rt3),t3-binding capacity (tbc) and tsh were measured in 10 children with diabetes mellitus (mean age: 12.8 +/- 2 yr). the children were without ketoacidosis and serum glucose concentrations were 10.64 +/- 1.68 mmol/l (sd). the mean concentrations of serum t4, t3, rt3, tbc and tsh were 116.35 +/- 10.68 nmol/l (sd), 2.81 +/- 0.33 nmol/l, 0.27 +/- 0.04 nmol/l, 1.087 +/- 0.031 and 3.16 +/- 0.9 mu iu ... | 1986 | 3780868 |
| progressive recruitment of follicular cells with graded secretory responsiveness during stimulation of the thyroid gland by thyrotropin. | one of the earliest responses of the thyroid cells to tsh is macropinocytosis with formation of intracellular colloid droplets. we demonstrate here that increasing stimulation with tsh not only elicits a highly individual macropinocytotic response among different follicular cells but that the fraction of tsh-responsive cells is also a function of the tsh dose. after pretreatment with t4, mice and rats were injected ip with bovine tsh and killed 2 h later. the macropinocytotic response to tsh was ... | 1987 | 3780572 |
| nuclear 3,5,3'-triiodothyronine (t3) in brown adipose tissue: receptor occupancy and sources of t3 as determined by in vivo techniques. | the amount and sources of t3 associated with high affinity, low capacity cellular nuclear receptors in brown adipose tissue (bat) have been estimated by in vivo pulse-labeling techniques. maximal binding capacity was measured by in vivo saturation analysis. nuclear receptor occupancy at endogenous levels of t3 and t4 in euthyroid rats was estimated from the equilibrium nuclear to serum ratio of tracer t3, and the locally generated nuclear t3 to serum t4 ratio after injecting tracer t3 and t4. th ... | 1987 | 3780570 |
| triiodothyronine binding in adult rat brain: compartmentation of receptor populations in purified neuronal and glial nuclei. | in order to investigate the localization of nuclear t3 receptors in adult rat brain, we have developed a technique for separating neuronal and glial nuclei, and compared nuclear t3 binding in both fractions. glial and neuronal nuclear populations were prepared by homogenization of the whole brain except the cerebellum, followed by discontinuous density gradient centrifugation in 2.4 and 2.2 m sucrose. for purposes of comparison, liver nuclei were prepared by centrifugation in 2.4 m sucrose. micr ... | 1987 | 3780566 |
| energy-dependent uptake of 3,5,3'-triiodo-l-thyronine in rat skeletal muscle. | the uptake of [125i]t3 in rat skeletal muscle was investigated by incubating intact soleus muscles with a tracer amount of [125i]t3. at 37 c [125i]t3 uptake increased asymptotically; at 60 min the muscle contained 10% of the total [125i]t3 or 0.238 +/- 0.021% per mg wet tissue. at 0 c the [125i]t3 uptake was 1/5 of that at 37 c. the specific [125i]t3 uptake, determined by subtracting the uptake in the presence of 10 microm unlabeled t3 from the total [125i]t3 uptake, attained a plateau after 60 ... | 1986 | 3780550 |
| a chemical 5'-phosphorylation of oligodeoxyribonucleotides. | to circumvent the use of t4 polynucleotide kinase and atp for the 5'-phosphorylation of synthetic oligodeoxyribonucleotides after deprotection and purification, we have developed a new chemical phosphorylation reagent that can be used on automated dna synthesis instruments. the phosphite-derived compound, bis(beta-cyanoethoxy)-n,n-diisopropylaminophosphine, is coupled to a solid-supported fragment and oxidized under the same conditions as nucleoside phosphoramidites. the resultant 5'-phosphate o ... | 1986 | 3780373 |
| [effect of hormonal and neurotrophic factors on the expression of fast myosin in slow muscle]. | myosin atpase and succinic dehydrogenase activity and fast myosin (indirect immunochemical test) were assayed in m. soleus of guinea-pigs after the administration of t4 (200 micrograms/kg) to animals every day for 3 weeks. this was followed by the application of 10 mm colchicine solution to sciatic nerve for 6 min. fast muscle fibers and the line of precipitation with antiserum to fast myosin were revealed in soleus muscle of experimental animals after the application of colchicine and t4 inject ... | 1986 | 3779067 |
| identification of surface-exposed segments of apolipoprotein b-100 in the ldl particle. | the isolation and amino acid sequence of eleven peptides liberated by tryptic treatment from surface-exposed regions of apolipoprotein b-100 in the native low-density lipoprotein particle are described. these peptides represent eight segments in the sequence of the b-100 protein, one of which was localised to the amino-terminal thrombolytic fragment t4 (1297 amino acids), four to the t3 fragment (2052 residues) and three to the carboxylterminal fragment t2 (1287 residues). an exposed segment was ... | 1986 | 3778445 |
| triiodothyronine (t3) neogenesis in lean and obese la/n-cp rats. | pre-obese la/n-cp rats consumed more food and gained weight more rapidly than their lean littermates, and measures of adipose tissue depots indicated that the excess weight was deposited principally as carcass fat. serum t3 concentrations and resting metabolic rates were lower in corpulent than in lean animals, consistent with a greater efficiency of weight gain in those animals. in vitro measures of t3 neogenesis from t4 were lower in corpulent than in lean animals in liver, kidney, and skeleta ... | 1986 | 3778441 |
| [acquired immunodeficiency syndrome in an adolescent hemophiliac]. | in an adolescent with hemophilia b, the diagnosis of aids was established in face of cachexia, orodigestive candidiasis, associated with lymphopenia, major decrease in t4/t8 ratio with marked decrease in t helper cells and presence of lav-antibodies. the patient died rapidly from a cerebral infection due to toxoplasma gondii. difficulties in diagnosis and treatment of cerebral toxoplasmosis are discussed. | 1986 | 3778094 |
| the effect of methimazole on the development of spontaneous lymphocytic thyroiditis in the diabetes-prone bb/w rat. | methimazole (mmi) administration decreases the incidence and intensity of experimentally induced lymphocytic thyroiditis (lt) in the female august rat and male a/j mouse. spontaneous lt frequently occurs in the insulin-dependent type-i diabetic (dm) bb/w rat. experiments were carried out to determine whether mmi administration to bb/w rats from 30 to 120 days of age would affect the incidence and intensity of spontaneous lt and the incidence of spontaneous dm. a total of 870 ng mmi/gm bw or sali ... | 1986 | 3777011 |
| serum tsh concentration as an aid to monitoring compliance with thyroid hormone therapy in hypothyroidism. | to monitor the compliance of patients taking levothyroxine as replacement therapy for primary hypothyroidism, the authors measured serum thyroid-stimulating hormone (tsh), free thyroxine index (ft4i), and free triiodothyronine index (ft3i) in patients attending the endocrine clinic. during a 6-month period, there were 159 visits by 132 patients with treated hypothyroidism. five of the 132 patients had tsh levels greater than 12 microu/ml (normal, 0.3-5.7 microu/ml), with ft3i greater than 85 (no ... | 1986 | 3777010 |
| amiodarone, thyroid hormone indexes, and altered thyroid function: long-term serial effects in patients with cardiac arrhythmias. | amiodarone, a drug that has electrophysiologic actions resembling those of hypothyroidism, increases serum levels of t4 and reverse t3 (rt3) and decreases t3. the drug's long-term effects on thyroid function are poorly defined. serial thyroid hormone indexes in 76 patients given amiodarone for 6 to 32 months (mean +/- standard deviation 16 +/- 7) for arrhythmias were determined serially. over this period, 68 patients (89%) remained euthyroid; hypothyroidism developed in 6 (8%) and hyperthyroidis ... | 1986 | 3776855 |
| effects of betamethasone on serum iodothyronines and thyroid hormone-binding proteins in graves' disease. | the influence of betamethasone on iodothyronines and their binding proteins in serum was studied in 18 patients with graves' disease. betamethasone, 6 mg daily, was given orally for 5 days. serum triiodothyronine (t3) concentration decreased, reverse triiodothyronine increased, while thyroxine (t4) and thyroid-stimulating hormone were unchanged. thyroxine-binding globulin (tbg) decreased and thyroxine-binding prealbumin increased. in accordance with the decrease in tbg, the in vitro t3 uptake in ... | 1986 | 3776699 |
| diminished hepatic triiodothyronine production in gunn rats. | the liver is a major site of conversion of thyroxine (t4) to the more active thyroid hormone 3,5,3'-triiodothyronine (t3). hepatic t4 to t3 conversion is altered by a variety of pathological processes and pharmacological agents. we studied t4 to t3 conversion in glucuronyl transferase deficient homozygous gunn rats because they have a hepatic enzyme abnormality which leads to hyperbilirubinaemia, and also because they have been reported to have alterations in thyroid hormone metabolism. an in vi ... | 1986 | 3776437 |
| [misuse of thyrostatic drugs in cattle: determination of thyroxine (t4) concentration and thyroid weight and detection of methylthiouracil (mtu)]. | 1986 | 3775350 | |
| action of some pesticides on t4 to t3 conversion in cultured kidney and liver cells in the presence or absence of cysteine. | the influence of aminotriazole (ata), atrazine (atz), prometryne (p) and atc on t4 to t3 conversion in kidney and liver cell cultures in the presence or absence of cysteine was studied. the experiment was carried out on cell cultures (rat renal cells and human embryo cells) and organotypic cultures (rat liver cells), treated with the above mentioned pesticides in 2 doses each, in the presence of 1 microgram and 10 micrograms t4 in the culture medium. this experiment was reproduced in the same co ... | 1986 | 3775222 |
| [hypophyseal-thyroid system in chronic alcoholism]. | the levels of the thyroid hormones in the peripheral blood of patients with stage i and ii chronic alcoholism increased moderately at the expense of ejection activation in the blood but not hyperproduction of the thyroid and correlated with a decrease in the secretion of corticosteroids and an increase in the acth level. disproportion of the t3 and t4 levels was in direct relation to a degree of alcoholic liver affection. in a long-term period following antialcoholic treatment hormonal function ... | 1986 | 3773661 |
| stimulatory effects of growth hormone and thyroxine on the concentration of gangliosides in the snell dwarf cerebrum. | the concentration of gangliosides in the snell dwarf mouse cerebrum was monitored from postnatal day 5 to day 40. in the dwarf cerebrum, the concentration of total gangliosides increased up to postnatal day 20 and then stopped, whereas in the control cerebrum, it continued to increase up to postnatal day 40. at postnatal day 40, the ganglioside level in the dwarf cerebrum was 70% of that in the control cerebrum. among the ganglioside species, the concentrations of gm4, gm2, gm1, gd1a, gd3, gd1b, ... | 1986 | 3772377 |
| [studies on the relationship between reproductive phenomena and thyroid function--dynamics of the concentrations of thyroid hormones in pregnancy, parturition and puerperium]. | thyroid function during pregnancy, parturition and puerperium was studied by measuring the concentration of free thyroxine (f-t4), free triiodothyronine (f-t3) and reverse triiodothyronine (r-t3) in maternal and cord sera, and simultaneously metabolism of thyroid hormones in chorionic tissues was examined. results obtained were as follows: in cases of normal pregnancy, maternal f-t4 and f-t3 levels tend to decrease during the course of pregnancy toward parturition. pathological pregnancies such ... | 1986 | 3772204 |
| humoral immune responses to t cell tropic retrovirus simian t lymphotropic virus type iii in monkeys with experimentally induced acquired immune deficiency-like syndrome. | the t cell tropic retrovirus of macaque monkeys simian t lymphotropic virus type iii (stlv-iii) has morphologic, growth, and antigenic properties indicating that it is related to human t cell lymphotropic virus type iii/lymphadenopathy-associated virus (htlv-iii/lav), the etiologic agent of the acquired immune deficiency syndrome (aids) of humans. stlv-iii has recently been shown to induce an aids-like disease in macaque monkeys. in this study the humoral immune responses of six experimentally i ... | 1986 | 3771794 |
| the effects of sodium ipodate (oragrafin) on thyroid function in rainbow trout, salmo gairdneri. | immature rainbow trout held at 12 +/- 1 degree were injected intraperitoneally with a fine saline suspension of sodium ipodate (5 mg/100 g body wt) every 3 days. plasma 3,5,3'-triiodo-l-thyronine (t3) fell to 40% of control levels by day 1 and remained at about this level for the duration of the study (22 days). plasma l-thyroxine (t4) level was not altered on day 1 but was lowered to 50% of control values by days 7 and 22. immersion of trout in t4 (2 micrograms/100 ml water) elevated plasma t4 ... | 1986 | 3770448 |
| annual cycle of plasma thyroid hormone levels in the toad, bufo japonicus. | plasma thyroxine (t4) of the toad, bufo japonicus formosus, was monitored monthly from march, 1981 to february, 1982. toads were captured at sayama, saitama prefecture, and individual blood samples were collected from the heart soon after capture in the field. the plasma t4 levels were minimal in november for males (0.096 ng/ml) and in december for females (0.038 ng/ml). levels increased during the resting stage in winter and reached a peak in march, about 1 week before the breeding migration, i ... | 1986 | 3770432 |
| relationship between circulating thyroid hormones and humoral immunity in immature male chickens. | the objective of this experiment was to examine the relationship between levels of circulating t3, t4, and humoral immunity in immature male chickens. three week old single comb white leghorn male chicks were used as the experimental animals. in order to produce a wide range of circulating thyroid hormone concentrations, birds were divided into groups and received one of nine treatments including surgical thyroidectomy; 0.1% propylthiouracil (ptu) in the feed; 1 ppm t3 and 10 ppm t4 in the feed. ... | 1986 | 3770270 |
| triiodothyronine (t3)-induced down-regulation of the nuclear t3 receptor in mouse preadipocyte cell lines. | as previously reported, preadipocytes cloned from the epididymal fat of lean or genetically obese mice (hgfu and ob 17, respectively) contain the nuclear t3 receptor. the number of receptor sites was similar in confluent cells of both lines and approximately doubled during adipocyte differentiation. t3 added to the culture medium increased triacylglycerol synthesis. t3 also increased fatty acid synthase specific activity, relative synthesis rate, and relative mrna content (1.5- to 2.5-fold). opt ... | 1986 | 3769873 |
| ontogenesis of growth hormone (gh)-responsive hepatic gene products: lack of correlation with hepatic gh receptor content. | the ontogenesis of hepatic gh receptor content is postulated as a major determinant of expression of hepatic gh-responsive gene products, since the ontogeny of the receptors and the responsive gene products, somatomedin-c, somatomedin-binding protein, and gh-responsive acidic protein, have similar qualitatively ontogenetic patterns. two-dimensional gel electrophoresis of in vitro synthesized [35s]methionine-labeled proteins formed in the cell-free mrna-dependent rabbit reticulocyte lysate system ... | 1986 | 3769871 |
| the role of 3,3',5'-triiodothyronine in the regulation of type ii iodothyronine 5'-deiodinase in the rat cerebral cortex. | type ii iodothyronine 5'-deiodinase (5'd-ii) activity is the source of 75-80% of the cerebral cortex t3 content in euthyroid rats. the activity of this enzyme is increased in hypothyroidism and can be quickly suppressed by t4 and rt3 by mechanisms involving neither protein synthesis nor nuclear t3 receptors. we have examined the possibility that endogenous cerebrocortical rt3 levels play a physiological role in the regulation of this enzyme. thyroidectomized rats were injected with graded doses ... | 1986 | 3769868 |
| identification and characterization of l-triiodothyronine receptors in cells of glial and neuronal origin. | high affinity-low capacity binding sites for thyroid hormone have been identified in the nuclei of glial (c6) and neuronal (neuro 2a) cultured cells. equilibrium dissociation constants, determined by scatchard analysis, were very similar in both types of cells (0.2-0.3 nm). the relative affinity of hormonal analogs was also similar: the affinity for t3 was lower than for triiodothyroacetic acid and higher than for t4 or tetraiodothyroacetic acid. the sedimentation coefficients obtained by gradie ... | 1986 | 3769867 |
| t3/t4 ratio in cimetidine treatment. | 1986 | 3769713 | |
| the wavelength dependence of u.v.-induced pyrimidine dimer formation, cell killing and mutation induction in human diploid skin fibroblasts. | in this study, we determined the wavelength dependence of u.v.-induced pyrimidine dimer formation, cell killing and mutation induction in human diploid skin fibroblasts. pyrimidine dimers were quantified using the t4 endonuclease v assay, cell killing was measured as loss of colony forming ability and mutation induction was detected at the hprt locus. u.v. irradiation was performed with monochromatic light of four different wavelengths (254, 297, 302 and 365 nm) and with polychromatic light of a ... | 1986 | 3769130 |
| hypothalamic neuroendocrine correlates of cutaneous burn injury in the rat: i. scanning electron microscopy. | rats were given a standard scald burn on 60% of the body surface or only a sham burn and were sacrificed at intervals from 6 hr to 14 days later. serum thyroxine (t4), free thyroxine index (ft4i) and triiodothyronine (t3) were depressed compared to values in respective shams as early as 6 hr post-burn. t4 and ft4i were less depressed on post-burn days (pbd) 2-3 than on pbd 1 and then exhibited a further fall. t3 remained depressed through pbd 14. pineal melatonin content was elevated at 6 hr and ... | 1986 | 3768739 |
| synthesis and properties of oligodeoxyribonucleotides containing an ethylated internucleotide phosphate. | internucleotide phosphotriesters comprise an important class of dna lesions produced by carcinogenic alkylating agents. to avoid confusion resulting from the presence of other dna lesions, synthetically prepared oligonucleotides containing ethylated internucleotide phosphates as the sole form of damage were employed to investigate several chemical and biochemical properties of dna alkyl phosphotriesters. a total of four oligonucleotides were synthesised for this study, the dimers tp(et)t and ptp ... | 1986 | 3768334 |
| [use of enzymun-t4 and enzymun-tbk tests to determine thyroid function in cattle]. | 1986 | 3767576 | |
| preparation of (t3 + t4)-free pooled plasma. | 1986 | 3767280 | |
| thyroid function tests in patients with familial dysalbuminaemic hyperthyroxinaemia (fdh). | two patients with familial dysalbuminaemic hyperthyroxinaemia (fdh) are described in whom the albumin variant resulted in raised total t4 levels, and artefactually raised free t4 using a 'single-step' technique employing an analogue of t4 as tracer. the first patient was clinically euthyroid and presented with relapse of schizophrenia and abnormal thyroid function tests (total t4 336 nmol/l, total t3 4.2 nmol/l, tsh 1.8 mu/l, free t4 73 pmol/l). these results led to diagnostic confusion and the ... | 1986 | 3767254 |
| [clinical analysis of high grade bladder cancer]. | the prognosis and other clinical manifestation of 128 patients with high grade bladder tumor were analyzed. thirty two percent of the total cases of bladder cancer were high grade bladder cancer and 83% of their tumors were invasive tumor at stage t2 and worse. urinary cytologies were positive in 88% of these patients. the 5-year survival rate in these patients was 32% and those in t1, t2 t3 and t4 cases were 64.2%, 55.6%, 22.7% and 8.0% respectively. the patients treated with radical (total) cy ... | 1986 | 3766339 |
| thyroid function tests in elderly finnish men. | serum total thyroxine (t4), triiodothyronine (t3) and thyrotrophin (tsh) levels were determined among 65-84-year-old finnish men living either in eastern finland (n = 309) or in southwestern finland (n = 389). the mean value for serum total t4 was 112.2 +/- 23.0 nmol/l in eastern finland and 111.3 +/- 21.9 nmol/l in southwestern finland. the mean value for serum t3 was 1.76 +/- 0.30 nmol/l in eastern finland and 1.75 +/- 0.46 nmol/l in southwestern finland. serum tsh values showed the mean for m ... | 1986 | 3766209 |
| a prospective critical evaluation of in vitro thyroid function tests. | a number of 2 325 serum samples from a population of in- and outpatients were collected during a six-month period in order to evaluate the usefulness of various thyroid function tests in the clinical laboratory routine. the samples were analysed with the following thyroid function tests: total triiodothyronine (t3) (tt3), total thyroxine (t4) (tt4), free t3 index (ft3i), free t4 index (ft4i) and thyrotropin (tsh). one to two years after the primary evaluation, a follow-up was performed and the f ... | 1986 | 3766208 |
| intestinal phosphate and calcium absorption: joint regulation by thyroid hormones and 1,25-dihydroxyvitamin d3. | thyroxine (t4) and triiodothyronine (t3) activate na+-dependent inorganic phosphate (pi) transport in organ-cultured embryonic chick small intestine. induction of transport activity requires intact protein synthesis and can be expressed in enterocytes with varying degrees of differentiation. t3 and t4 exert their effect independent of 1,25-dihydroxyvitamin d3 (1,25(oh)2d3), which is shown to stimulate pi uptake only in the final stage of embryonic differentiation. at this time point, a potentiat ... | 1986 | 3766052 |
| conversion of thyroxine to 3,5,3'-triiodothyronine in several rat tissues in vivo: the effect of hypothyroidism. | the local conversion of thyroxine (t4) to 3,5,3'-triiodothyronine (t3) has been recognized as a source of t3 at various sites in euthyroid rats. the present study was designed to evaluate the effect of hypothyroidism on the source and quantity of t3 at several of these sites (liver, cerebral cortex (cx), thymus, testis, brown adipose tissue). for this purpose intact euthyroid rats and radiothyroidectomized (rtx) rats received a continuous iv infusion of [125i]t4 and [131i]t3 until isotopic equil ... | 1986 | 3766050 |
| variation in serum levels of t3, t4, ft4 and tsh during thyroxine replacement therapy. | serum levels of t3, t4, ft4 and tsh were determined in 9 euthyroid patients during 6 h after intake of morning thyroxine replacement medication. four hypothyroid patients were studied in the same way after the intake of 50 micrograms thyroxine. in the euthyroid patients the ft4 level increased by 31%, while the increase of t4 was 16% and the increase of t3 11%. in the hypothyroid patients levels of t3, t4 and ft4 did not change after ingestion of 50 micrograms thyroxine, while the tsh level was ... | 1986 | 3766048 |
| relationships between thyroid hormone and catecholamines in experimental trauma. | the relationship between thyroid hormones (t4 and t3) and the catecholamines (adrenaline and noradrenaline) was studied as regards the possible value of administered t3 in the treatment of severely injured patients. preparative surgery was performed on 36 pigs, 26 of which were then submitted to a standardized high-energy missile trauma to a hind leg. in 14 of the latter group, infusion of t3 was begun immediately before the trauma (n = 6), or after a delay of 8 h (n = 4) or 24 h (n = 4). a corr ... | 1986 | 3766027 |
| effects of frequent and sustained plateletapheresis on peripheral blood mononuclear cell populations and lymphocyte functions of normal volunteer donors. | per procedure, plateletapheresis may remove 2 x 10(9) to 3 x 10(9) white cells from the peripheral blood of a normal donor. to investigate the effects of frequent and sustained plateletapheresis, multiple peripheral blood tests were performed on 25 volunteer donors undergoing plateletapheresis an average of 72 times over periods of up to 8 years, and results were compared with 25 age- and sex-matched controls who had not undergone apheresis. in donors, significant decreases were observed in: 1) ... | 1986 | 3765039 |
| [preoperative tumor staging in rectal cancer--a prospective study]. | a precise preoperative tumor staging is the prerequisite of distinct treatment planning and subtle operative regimen. diagnostic contribution of the various examination techniques especially of imaging modalities were determined in a prospective study and correlated to intra- and postoperative findings. the tnm classification of malignant tumors of the uicc, both in its present valid and the modified form to be introduced in january 1987, formed the basis of our clinical diagnostic staging. diag ... | 1986 | 3763846 |
| [reflexometry: an early prognostic test for assessing postoperative hypothyroidism]. | the serum content of thyroxin (t4) and the duration of achilles reflex was studied in 23 patients with toxic goiter 1-3 months after subtotal thyroidectomy. concentration of t4 assessed in the serum revealed 9 euthyroid subjects and 14 patients with hypothyrosis. but as the duration of achilles tendon reflex was within the norm in all 14 hypothyrosis patients reflexometry technique turned to be inconsistent in distinguishing between hypo- and euthyroidism. however the high prognostic value of th ... | 1986 | 3763567 |
| the effects of d-phenylalanine and its derivatives on enkephalin degradation in vitro: relation to analgesia and attenuation of the morphine withdrawal syndrome. | the effect of d-phenylalanine (d-phe), putative carboxypeptidase a inhibitor and its four derivatives (t1-t4) on analgesia, development of tolerance and physical dependence to morphine, and on degradation of both exogenous and endogenous enkephalins was investigated. systemic administration of either d-phe or its derivatives produced naloxone-reversible analgesia in the hot-plate test in mice. naloxone-precipitated morphine withdrawal syndrome was attenuated in mice after systemic subacute admin ... | 1986 | 3763485 |