Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [treatment strategy for gastric carcinoma with lymphoid stroma]. | gastric carcinoma with lymphoid stroma (gcls) is a histological type with severe lymphocytic infiltration. gcls is very rare and few cases have been reported. we examined the clinical features, problems of preoperative diagnosis, and treatment of 14 cases (1.8%) that were diagnosed as gcls out of 790 gastric cancers surgically resected in our hospital. the mean age was 69 years. six, 8, and 0 cases were located in the upper, middle, and lower fields of the stomach, respectively, and 8, 1, 4, and ... | 2015 | 26805251 |
| inhibition of herpes virus infection in oligodendrocyte cultured cells by valproic acid. | valproic acid (vpa) is a small fatty acid used for treatment of different neurologic diseases such as epilepsy, migraines or bipolar disorders. vpa modulates different processes of cell metabolism that can lead to alterations in susceptibility of several cell types to the infection of human immunodeficiency virus (hiv), epstein-barr virus (ebv), as well as to exert an inhibitory effect on the replication of different enveloped viruses in cultured cells. taken these data into account and the fact ... | 2016 | 26805038 |
| atypical manifestations of epstein-barr virus in children: a diagnostic challenge. | clarify the frequency and the pathophysiological mechanisms of the rare manifestations of epstein-barr virus infection. | 2016 | 26802473 |
| metabolic stress is a barrier to epstein-barr virus-mediated b-cell immortalization. | epstein-barr virus (ebv) is an oncogenic herpesvirus that has been causally linked to the development of b-cell and epithelial malignancies. early after infection, ebv induces a transient period of hyperproliferation that is suppressed by the activation of the dna damage response and a g1/s-phase growth arrest. this growth arrest prevents long-term outgrowth of the majority of infected cells. we developed a method to isolate and characterize infected cells that arrest after this early burst of p ... | 2016 | 26802124 |
| co-infection of epstein-barr virus and human papillomavirus in human tumorigenesis. | viral infections contribute to approximately 12% of cancers worldwide, with the vast majority occurring in developing countries and areas. two dna viruses, epstein-barr virus (ebv) and human papillomavirus (hpv), are associated with 38% of all virus-associated cancers. the probability of one patient infected with these two distinct types of viruses is increasing. here, we summarize the co-infection of ebv and hpv in human malignancies and address the possible mechanisms for the co-infection of e ... | 2016 | 26801987 |
| patterns of pd-l1 expression and cd8 t cell infiltration in gastric adenocarcinomas and associated immune stroma. | recent data supports a significant role for immune checkpoint inhibitors in the treatment of solid tumours. here, we evaluate gastric and gastro-oesophageal junction (g/gej) adenocarcinomas for their expression of programmed death-ligand 1 (pd-l1), infiltration by cd8+ t cells and the relationship of both factors to patient survival. | 2017 | 26801886 |
| prevalence of peri-implantitis in medically compromised patients and smokers: a systematic review. | to verify whether the diversity of systemic medical conditions and smoking act as biologic associated factors for peri-implantitis. | 2016 | 26800167 |
| a viral microrna cluster regulates the expression of pten, p27 and of a bcl-2 homolog. | the epstein-barr virus (ebv) infects and transforms b-lymphocytes with high efficiency. this process requires expression of the viral latent proteins and of the 3 mir-bhrf1 micrornas. here we show that b-cells infected by a virus that lacks these non-coding rnas (δ123) grew more slowly between day 5 and day 20, relative to wild type controls. this effect could be ascribed to a reduced s phase entry combined with a moderately increased apoptosis rate. whilst the first phenotypic trait was consist ... | 2016 | 26800049 |
| comprehensive phenotypic characterization of ptld reveals potential reliance on ebv or nf-κb signalling instead of b-cell receptor signalling. | post-transplant lymphoproliferative disorders (ptld) are a major problem in transplant medicine. so far, the insights into pathogenesis and potentially druggable pathways in ptld remain scarce. we investigated a cohort of ptld patients, consisting of both polymorphic (n = 3) and monomorphic (n = 19) b-cell lymphoproliferations. several signalling pathways, cell of origin of ptld and their relation to viruses were analysed by immunohistochemistry and in situ hybridization. most ptld were of activ ... | 2016 | 26799990 |
| classic and extracavitary primary effusion lymphoma in 51 hiv-infected patients from a single institution. | human immunodeficiency virus (hiv)-associated primary effusion lymphoma (pel) is a rare b-cell non-hodgkin lymphoma with poor prognosis. lymphoma cells are always infected with human herpesvirus-8 (hhv-8) and in most cases coinfected with epstein-barr virus. in classic presentation, pel is characterized by body cavity effusions with or without mass lesions. a variant with only extracavitary localization has also been described. we report on a large single-center series of patients with pel in th ... | 2016 | 26799611 |
| application of synthetic peptides for detection of anti-citrullinated peptide antibodies. | anti-citrullinated protein antibodies (acpas) are a hallmark of rheumatoid arthritis (ra) and represent an important tool for the serological diagnosis of ra. in this study, we describe acpa reactivity to overlapping citrullinated epstein-barr virus nuclear antigen-1 (ebna-1)-derived peptides and analyze their potential as substrates for acpa detection by streptavidin capture enzyme-linked immunosorbent assay. using systematically overlapping peptides, containing a 10 amino acid overlap, labelle ... | 2016 | 26796582 |
| human wharton's jelly-derived mesenchymal stromal cells engineered to secrete epstein-barr virus interleukin-10 show enhanced immunosuppressive properties. | mesenchymal stromal cells (mscs) modulate the immune response and represent a potential treatment for inflammatory and autoimmune diseases. we hypothesized that this feature could be potentiated by co-administering anti-inflammatory cytokines. in this article, we asked whether engineering of wharton jelly-derived human mscs (wj-hmscs) to express an anti-inflammatory cytokine increases cell immunomodulatory properties without altering their native features. | 2016 | 26794713 |
| visceral leishmaniasis in a patient with systemic lupus erythematosus. | visceral leishmaniasis is an infection with an insidious and disabling course caused by parasites of the genus leishmania. in europe, it is mostly associated with hiv infection. systemic lupus erythematosus and its treatment are associated with increased risk of infection, neoplastic and concomitant autoimmune disorders. the association of these diseases may go unnoticed. a 60 year-old caucasian woman with lupus presented with a one-year history of fever, malaise, weakness and weight loss. the h ... | 2015 | 26793472 |
| clinicopathologic features and treatment of breast metastasis from nasopharyngeal carcinoma: a report of two cases and literature review. | breast metastasis is a rare pattern of distant metastasis from nasopharyngeal carcinoma (npc) following curative treatment. the present study reported two patients with breast metastasis from npc and reviewed four such patients reported in the literature, including the analysis of clinical profiles, pathological diagnoses, treatment strategies and outcomes. the breast is a potential metastatic site for patients with npc following curative treatment; however, thus far, only metachronous breast me ... | 2015 | 26788190 |
| consideration of epstein-barr virus-encoded noncoding rnas eber1 and eber2 as a functional backup of viral oncoprotein latent membrane protein 1. | the epstein-barr virus (ebv)-encoded noncoding rnas eber1 and eber2 are highly abundant through all four latency stages of ebv infection (iii-ii-i-0) and have been associated with an oncogenic phenotype when expressed in cell lines cultured in vitro. in vivo, ebv-infected b cells derived from freshly isolated lymphocytes show that eber1/2 deletion does not impair viral latency. based on published quantitative proteomics data from bjab cells expressing eber1 and eber2, we propose that the ebers, ... | 2016 | 26787829 |
| identification of kaposi sarcoma herpesvirus (kshv) virf1 protein as a novel interaction partner of human deubiquitinase usp7. | viral interferon regulatory factor 1 (virf1), a kaposi sarcoma herpesvirus protein, destabilizes p53 by inhibiting p53 acetylation and hdm2 phosphorylation. this leads to increased ubiquitination and degradation of p53 by hdm2, which cripples the cellular p53-mediated antiviral response. ubiquitin-specific protease 7 (usp7) deubiquitinates p53 and hdm2 and regulates their stability. we identified an egps consensus sequence in virf1, which is identical to that found in epstein-barr virus nuclear ... | 2016 | 26786098 |
| morphological and cellular features of innate immune reaction in helicobacter pylori gastritis: a brief review. | innate and adaptive immunity are both involved in acute and chronic inflammatory processes. the main cellular players in the innate immune system are macrophages, mast cells, dendritic cells, neutrophils, eosinophils, and natural killer (nk), which offer antigen-independent defense against infection. helicobacter pylori (h. pylori) infection presents peculiar characteristics in gastric mucosa infrequently occurring in other organs; its gastric colonization determines a causal role in both gastri ... | 2016 | 26784180 |
| the epstein-barr virus encoded lmp1 oncoprotein modulates cell adhesion via regulation of activin a/tgfβ and β1 integrin signalling. | approximately 20% of global cancer incidence is causally linked to an infectious agent. epstein-barr virus (ebv) accounts for around 1% of all virus-associated cancers and is associated with nasopharyngeal carcinoma (npc). latent membrane protein 1 (lmp1), the major oncoprotein encoded by ebv, behaves as a constitutively active tumour necrosis factor (tnf) receptor activating a variety of signalling pathways, including the three classic mapks (erk-mapk, p38 mapk and jnk/sapk). the present study ... | 2016 | 26782058 |
| outpatient management of patients with acute tonsillitis and peritonsillar abscess in ninety adult patients. | ethical considerations: the protocol used in this evaluation was based upon current best practices and was reviewed and accepted by departmental heads prior to use. a protocol (see figure 1) was devised based upon the aforementioned current evidence base.(3-6) patients already able to eat and drink prior to treatment were excluded from the protocol; such cases were expected to be managed as outpatients in our trust. patients unable to eat and drink were then stratified according to risk level, w ... | 2016 | 26780978 |
| shaping the molecular landscape of posttransplantation lymphoproliferative disorders. | 2016 | 26780686 | |
| ebv-positive and ebv-negative posttransplant diffuse large b cell lymphomas have distinct genomic and transcriptomic features. | the molecular pathogenesis of posttransplant diffuse large b cell lymphoma (pt-dlbcl) is largely unknown. we have recently shown that epstein-barr virus-positive (ebv(+)) and -negative (ebv(-)) pt-dlbcl have distinct gene expression profiles, and the transcriptomic profile of ebv(-) pt-dlbcl is similar to that of dlbcl in immunocompetent individuals (ic-dlbcl). to validate these observations at the genomic level, we performed array-comparative genome hybridization (acgh) analysis of 21 ebv(+) pt ... | 2016 | 26780579 |
| primary hepatic epstein-barr virus-associated cd30-positive peripheral t-cell lymphoma of cytotoxic phenotype. | primary hepatic peripheral t-cell lymphoma (ptcl) is exceedingly rare. we encountered such a case in a 58-year-old hispanic female with a history of chronic sinusitis and hypothyroidism who presented with 4weeks of fever and weight loss. laboratory studies showed altered liver function and mild pancytopenia. hepatitis and hiv infection were excluded by negative serological tests. a computed tomography (ct) scan showed innumerable small low-density lesions throughout the liver without splenomegal ... | 2016 | 26778690 |
| spontaneous regression of epstein-barr virus-positive primary diffuse large cell b-cell lymphoma of the urinary bladder after the cessation of enzalutamide. | 2016 | 26778299 | |
| the prevalence of infectious agents in patients with systemic sclerosis. | systemic sclerosis (ssc) is an autoimmune disease characterized by microvascular injury, excessive extracellular matrix deposition, and fibrosis in the skin and internal organs. bacterial and viral infectious agents have been suspected to be contributing factors in the development and progression of the pathologic features of ssc. | 2015 | 26775370 |
| next generation sequencing revealed dna ligase iv deficiency in a "developmentally normal" patient with massive brain epstein-barr virus-positive diffuse large b-cell lymphoma. | here we present an unusual case of dna ligase iv deficiency syndrome without dysmorphic facial findings and microcephaly complicated with epstein-barr virus-associated large b-cell lymphoma with the right lung involvement and a massive brain tumor lesion in a two-year-old female. | 2016 | 26774591 |
| pharmacophore-based screening targeted at upregulated fn1, mmp-9, app reveals therapeutic compounds for nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is rare in the west but common in southeast asia and only a few other locations. with the limited geographic incidence, it is relatively under-studied. it also has as co-determinant the epstein-barr virus (ebv), which may adapt to npc therapies, so not only must a therapeutic compound be found, the discovery process must be rapid, to cope with the changing basis of the ebv. an r-based computer workbench, mendel, was developed so biologists could quickly upload geno ... | 2016 | 26773938 |
| extranodal nk/t-cell lymphoma, nasal type, manifesting as rapidly progressive dementia without any mass or enhancing brain lesion. | among the many potential etiologies for rapidly progressive dementia (rpd), primary central nervous system extranodal nk/t-cell lymphoma, nasal-type (enkl) is a rare entity. we present the first reported case of autopsy-proven rpd due to enkl without any mass or enhancing lesion of the brain. a 54-year-old immunocompetent man presented with rpd, myoclonus and ataxia. the mini-mental state examination (mmse) score was 22/30. his brain mri revealed progressive brain atrophy without gadolinium enha ... | 2016 | 26773724 |
| epstein-barr virus glycoprotein gm can interact with the cellular protein p32 and knockdown of p32 impairs virus. | the epstein-barr virus glycoprotein complex gmgn has been implicated in assembly and release of fully enveloped virus, although the precise role that it plays has not been elucidated. we report here that the long predicted cytoplasmic tail of gm is not required for complex formation and that it interacts with the cellular protein p32, which has been reported to be involved in nuclear egress of human cytomegalovirus and herpes simplex virus. although redistribution of p32 and colocalization with ... | 2016 | 26773383 |
| an analysis of myc and ebv in diffuse large b-cell lymphomas associated with angioimmunoblastic t-cell lymphoma and peripheral t-cell lymphoma not otherwise specified. | composite diffuse large b-cell lymphomas (dlbcls) with peripheral t-cell lymphomas (ptcls) are rare co-occurrences with poorly understood pathologic features. herein, we describe 15 distinct cases of dlbcl occurring in association with ptcl, including angioimmunoblastic t-cell lymphoma (aitl; n = 12) and ptcl, not otherwise specified (n = 3). sheets of large b cells were seen in all cases, with hodgkin/reed-sternberg-like (hrs-l) cells present in 6 cases. when compared to cases of aitl without d ... | 2016 | 26772393 |
| humoral response to ebv is associated with cortical atrophy and lesion burden in patients with ms. | because dysregulated epstein-barr virus (ebv)-infected b cells may induce meningeal inflammation, which contributes to cortical pathology in multiple sclerosis (ms), we investigated associations between antibody responses to ebv and development of cortical pathology in ms. | 2016 | 26770996 |
| sensing of latent ebv infection through exosomal transfer of 5'ppprna. | complex interactions between dna herpesviruses and host factors determine the establishment of a life-long asymptomatic latent infection. the lymphotropic epstein-barr virus (ebv) seems to avoid recognition by innate sensors despite massive transcription of immunostimulatory small rnas (ebv-ebers). here we demonstrate that in latently infected b cells, eber1 transcripts interact with the lupus antigen (la) ribonucleoprotein, avoiding cytoplasmic rna sensors. however, in coculture experiments we ... | 2016 | 26768848 |
| primary extranodal nk/t-cell lymphoma of the lung: mimicking bronchogenic carcinoma. | primary extranodal natural killer/t- cell lymphoma, nasal type (nk/tcl) in the lung is extremely rare and associated with epstein-barr virus (ebv) infection. an 80-year-old male presented with hemoptysis, which had lasted three days. physical examination revealed inspiratory crackles at the left lung base and massive splenomegaly. chest radiograph shows a mass-like lesion in the left lower lung but no active lesion six months earlier. computed tomography demonstrated a soft tissue mass (size: 6. ... | 2014 | 26766981 |
| lack of epidermal growth factor receptor gene mutations in exons 19 and 21 in primary lymphoepithelioma-like carcinoma of the lung. | primary lymphoepithelioma-like carcinoma (lelc) of the lung is uncommon in non-small cell lung cancer (nsclc). epidermal growth factor receptor (egfr) targeted therapy has been applied in advanced common nsclc. whether egfr-targeted therapy is also suitable for lelc of the lung remains unclear. as we know, egfr gene mutation is a predictive factor. therefore, egfr gene mutations in exons 19 and 21 in chinese patients with lelc of the lung were investigated. | 2014 | 26766974 |
| inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in xlp-1. | x-linked lymphoproliferative disease (xlp-1) is an often-fatal primary immunodeficiency associated with the exuberant expansion of activated cd8(+) t cells after epstein-barr virus (ebv) infection. xlp-1 is caused by defects in signaling lymphocytic activation molecule (slam)-associated protein (sap), an adaptor protein that modulates t cell receptor (tcr)-induced signaling. sap-deficient t cells exhibit impaired tcr restimulation-induced cell death (ricd) and diminished tcr-induced inhibition o ... | 2016 | 26764158 |
| secreted oral epithelial cell membrane vesicles induce epstein-barr virus reactivation in latently infected b cells. | in the oral epithelium, peripheral stores of epstein-barr virus (ebv) are transmitted from infiltrating b cells to epithelial cells. once the virus is transmitted to epithelial cells, the highly permissive nature of this cell type for lytic replication allows virus amplification and exchange to other hosts. since the initial transfer of ebv from b cells to epithelial cells requires transitioning of the b-cell to a state that induces virus reactivation, we hypothesized that there might be epithel ... | 2016 | 26764001 |
| intraocular relapse with hypopyon and retinal infiltrates after chemotherapy and peripheral blood stem cell transplantation for extranodal nk/t-cell lymphoma. | we report a case of intraocular relapse of extranodal nk/t-cell lymphoma with anterior chamber hypopyon and retinal infiltrates. a 55-year-old man developed fever, malaise, anorexia, and hepatosplenomegaly, and was diagnosed with nk/t-cell lymphoma by liver biopsy. he underwent 2 courses of smile (dexamethasone, methotrexate, ifosfamide, l-asparaginase, and etoposide) chemotherapy, followed by myeloablative peripheral blood stem cell transplantation, donated by his brother. two months later, he ... | 2015 | 26763364 |
| intrafollicular epstein-barr virus-positive large b cell lymphoma. a variant of "germinotropic" lymphoproliferative disorder. | germinotropic lymphoproliferative disorders were previously described as localized disorders associated with coinfection by human herpes virus 8 and epstein-barr virus and characterized by good clinical outcome. we report the clinical, morphological, phenotypical, and molecular features of three cases of a hitherto unreported variant of epstein-barr virus (ebv)-positive, human herpes virus 8 (hhv8)-negative large b cell lymphoma with exclusive intrafollicular localization. all cases occurred in ... | 2016 | 26762526 |
| profile of the pleximmune blood test for transplant rejection risk prediction. | the pleximmune™ test (plexision inc., pittsburgh, pa, usa) is the first cell-based test approved by the us fda, which predicts acute cellular rejection in children with liver- or intestine transplantation. the test addresses an unmet need to improve management of immunosuppression, which incurs greater risks of opportunistic infections and epstein-barr virus-induced malignancy during childhood. high-dose immunosuppression and recurrent rejection after intestine transplantation also result in a 5 ... | 2016 | 26760313 |
| practical applications in immunohistochemistry: evaluation of rejection and infection in organ transplantation. | -immunohistochemical analysis of tissue biopsy specimens is a crucial tool in diagnosis of both rejection and infection in patients with solid organ transplants. in the past 15 years, the concept of antibody-mediated rejection has been refined, and diagnostic criteria have been codified in renal, heart, pancreas, and lung allografts (with studies ongoing in liver, small intestine, and composite grafts), all of which include immunoanalysis for the complement split product c4d. | 2016 | 26759930 |
| overexpression of tlr2 and tlr9 on monocyte subsets of active rheumatoid arthritis patients contributes to enhance responsiveness to tlr agonists. | synovial infiltration of monocytes is commonly associated with inflammation in rheumatoid arthritis (ra). toll-like receptors (tlrs) are innate sensors that recognize cell debris and microbial components in host, a process contributing to maintain chronic inflammation in ra. we assessed the expression levels of tlr2 and tlr9 in monocyte subsets of active ra patients and characterized their cytokine profiles in response to synthetic and viral tlr2 and tlr9 agonists, including epstein-barr virus ( ... | 2016 | 26759164 |
| [treatment of gaucher disease with allogeneic hematopoietic stem cell transplantation: report of three cases and review of literatures]. | to explore the efficacy of unrelated umbilical cord blood transplantation (ucbt) in the treatment of gaucher disease. | 2015 | 26758318 |
| meningitis and meningoencephalitis among israel defense force soldiers: 20 years experience at the hadassah medical centers. | meningitis and meningoencephalitis pose major risks of morbidity and mortality. | 2015 | 26757567 |
| acute acalculous cholecystitis by epstein-barr virus infection: a rare association. | acute acalculous cholecystitis (aac) is a rare complication of epstein barr virus (ebv) infection, with only a few cases reported among pediatric population. this clinical condition is frequently associated with a favorable outcome and, usually, a surgical intervention is not required. we report a 16-year-old girl who presented with aac following primary ebv infection. the diagnosis of aac was documented by clinical and ultrasonographic examination, whereas ebv infection was confirmed serologica ... | 2015 | 26753086 |
| ebna2 drives formation of new chromosome binding sites and target genes for b-cell master regulatory transcription factors rbp-jκ and ebf1. | epstein-barr virus (ebv) transforms resting b-lymphocytes into proliferating lymphoblasts to establish latent infections that can give rise to malignancies. we show here that ebv-encoded transcriptional regulator ebna2 drives the cooperative and combinatorial genome-wide binding of two master regulators of b-cell fate, namely ebf1 and rbp-jκ. previous studies suggest that these b-cell factors are statically bound to target gene promoters. in contrast, we found that ebna2 induces the formation of ... | 2016 | 26752713 |
| evaluation of serum granulysin as a potential biomarker for nasopharyngeal carcinoma. | granulysin (gnly) is excreted from cytotoxic t lymphocytes and natural killer cells, and plays an important role in antitumor immunity. however, few studies have estimated serum gnly concentrations in patients with nasopharyngeal carcinoma (npc). we evaluated gnly as a potential biomarker for npc. | 2016 | 26751807 |
| ebna3c directs recruitment of rbpj (cbf1) to chromatin during the process of gene repression in ebv infected b cells. | it is well established that epstein-barr virus nuclear antigen 3c (ebna3c) can act as a potent repressor of gene expression, but little is known about the sequence of events occurring during the repression process. to explore further the role of ebna3c in gene repression-particularly in relation to histone modifications and cell factors involved-the three host genes previously reported as most robustly repressed by ebna3c were investigated. cobll1, a gene of unknown function, is regulated by ebn ... | 2016 | 26751214 |
| post-transplant lymphoproliferative disorder following kidney transplantation: a population-based cohort study. | post-transplant lymphoproliferative disorder (ptld) incidence is difficult to determine, mainly because both early and other lesions may go unrecognized and unregistered. few studies have included systematic pathology review to maximize case identification and decide more accurately ptld frequency after long-term post-transplantation follow-up. a retrospective population-based cohort study including all kidney transplant recipients at two danish centres (1990-2011; population covered 3.1 million ... | 2016 | 26749337 |
| 5'utr +24t>c cr2 is not associated with nasopharyngeal carcinoma development in the north region of portugal. | we have analysed the association of the +24t>c polymorphism (rs3813946) in cr2, the cellular receptor for epstein-barr virus (ebv), in the susceptibility for the development of nasopharyngeal carcinoma (npc). | 2016 | 26748973 |
| the clinical significance of ebv dna in the plasma and peripheral blood mononuclear cells of patients with or without ebv diseases. | epstein-barr virus (ebv) is a ubiquitous virus that establishes a latent infection within the host and in some cases can lead to the development of ebv-associated lymphomas, lymphoproliferative disorders, hemophagocytic lymphohistiocytosis, solid tumors, and other diseases. we studied the clinical significance of detecting ebv dna in the plasma and peripheral blood mononuclear cells (pbmcs) of 2146 patients who had blood specimens sent to the johns hopkins hospital clinical laboratory for viral ... | 2016 | 26744460 |
| the prognostic role of eber in pediatric cancer. | the epstein-barr virus (ebv) infection is an endemic disease, over 90% of the population being exposed to it by adulthood. ebv is implicated in the etiology of a significant number of neoplasms, which acquire particular features in terms of course and prognosis. incidence rates are much higher in children. to establish the link between ebv and neoplasms, eber (epstein-barr virus non-encoded rnas) needs to be highlighted in tumor tissue. the role of ebv in patient response to oncological treatmen ... | 2015 | 26743271 |
| advances in understanding the pathogenesis of epstein-barr virus-associated lymphoproliferative disorders. | epstein-barr virus (ebv) was discovered 50 years ago from an african burkitt lymphoma cell line. ebv-associated lymphoproliferative disorders (lpds) are life- threatening diseases, especially in children. in this article, we review ebv-associated lpds, especially in the area of primary immunodeficiency disease (pid). we searched pubmed for publications with key words including ebv infection, lymphoma, lpds and pid, and selected the manuscripts written in english that we judged to be relevant to ... | 2015 | 26742434 |
| utility of 18f-fdg pet/ct in the assessment of lymphoepithelioma-like carcinoma. | lymphoepithelioma-like carcinoma (lelc) is a rare epstein-barr virus (ebv)-related disease, which commonly originates from the lung and is associated with more favourable treatment outcomes compared with other non-lelc thoracic carcinomas. radiological assessment utilizing fluorine-18 fluorodeoxyglucose pet combined with computed tomography (f-fdg pet/ct) is important for initial disease staging to tailor the treatment strategy, evaluation of treatment response and detection of disease recurrenc ... | 2016 | 26741291 |
| cd123 redirected multiple virus-specific t cells for acute myeloid leukemia. | hematopoietic stem cell transplantation (hsct) has been increasingly used as a curative treatment for acute myeloid leukemia (aml). however, relapse rates after hsct in complete remission (cr) are reported between 30% and 70%. in addition, numerous studies suggested that secondary viral infection from a variety of viruses including epstein-barr virus (ebv), adenovirus (adv), and cytomegalovirus (cmv) are among the most common causes of death post-hsct. currently, chimeric antigen receptor (car)- ... | 2016 | 26740053 |
| search for the potential "second-hit" mechanism underlying the onset of familial hemophagocytic lymphohistiocytosis type 2 by whole-exome sequencing analysis. | familial hemophagocytic lymphohistiocytosis type 2 (fhl2), caused by perforin 1 (prf1), is a genetic disorder of lymphocyte cytotoxicity that usually presents in the first 2 years of life and has a poor prognosis. late onset of fhl2 has been sporadically reported, and the mechanism is largely unknown. a newly diagnosed fhl2 patient was detected to have compound mutations in both prf1 alleles and positive epstein-barr virus (ebv) infection. her brother carried the same mutations and ebv infection ... | 2016 | 26739415 |
| carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism. | current proposed mechanisms implicate both early and latent epstein-barr virus (ebv) infection in the carcinogenic cascade, whereas epidemiological studies have always associated nasopharyngeal carcinoma (npc) with early childhood ebv infection and with chronic ear, nose, and sinus conditions. moreover, most patients with npc present with iga antibody titers to ebv capsid antigen (vca-iga), which can precede actual tumor presentation by several years. if early childhood ebv infection indeed cons ... | 2016 | 26738743 |
| central nervous system ebv lymphoproliferative disorder in a patient with rhabdomyosarcoma. | epstein-barr virus associated lymphoproliferative disorder (ebv-lpd) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. we describe a child with rhabdomyosarcoma who developed isolated central nervous system (cns) ebv-lpd during combination chemotherapy with vincristine, actinomycin d and cyclophosphamide. the patient was treated with high-dose methotrexate (hd-mtx) for cns ebv-lpd and then treated with rituxi ... | 2016 | 26738608 |
| multiple sclerosis between genetics and infections: human endogenous retroviruses in monocytes and macrophages. | the etiology of multiple sclerosis (ms) is still unknown, but there is strong evidence that genetic predisposition associated with environmental factors can trigger the disease. an estimated 30 million years ago, exogenous retroviruses are thought to have integrated themselves into human germ line cells, becoming part of human dna and being transmitted over generations. usually such human endogenous retroviruses (hervs) are silenced or expressed at low levels, but in some pathological conditions ... | 2015 | 26734011 |
| the pseudorabies virus dna polymerase processivity factor ul42 exists as a monomer in vitro and in vivo. | the processivity factors (pfs) of herpesviruses confer processivity to the dna polymerase. understanding whether the herpesvirus pfs function as monomers or multimers is important for clarifying the mechanism by which they provide the dna polymerase with processivity. herpes simplex virus type 1 ul42 is a monomer, whereas human cytomegalovirus ul44, epstein-barr virus bmrf1, and kaposi's sarcoma-associated herpesvirus pf-8 exist as dimers. however, the oligomeric status of the pseudorabies virus ... | 2016 | 26733297 |
| transmission of cytomegalovirus, epstein-barr virus, and herpes simplex virus infections: from the lucy australopithecus epoch to modern-day netherlands. | 2016 | 26732408 | |
| monitoring of epstein-barr virus (ebv)/cytomegalovirus (cmv)/varicella-zoster virus (vzv) load in patients receiving tocilizumab for rheumatoid arthritis. | il-6 is involved in viral immunosurveillance. we studied the effect of tocilizumab (tcz) on the evolution in viral load (vl) for the epstein-barr virus (ebv), cytomegalovirus (cmv) and varicella-zoster virus (vzv) in patients with rheumatoid arthritis (ra). | 2016 | 26725744 |
| increased expression of toll-like receptors 7 and 9 in myasthenia gravis thymus characterized by active epstein-barr virus infection. | considerable data implicate the thymus as the main site of autosensitization to the acetylcholine receptor in myasthenia gravis (mg), a b-cell-mediated autoimmune disease affecting the neuromuscular junction. we recently demonstrated an active epstein-barr virus (ebv) infection in the thymus of mg patients, suggesting that ebv might contribute to the onset or maintenance of the autoimmune response within mg thymus, because of its ability to activate and immortalize autoreactive b cells. ebv has ... | 2016 | 26723518 |
| pretreatment with anti-thymocyte globulin versus no anti-thymocyte globulin in patients with haematological malignancies undergoing haemopoietic cell transplantation from unrelated donors: a randomised, controlled, open-label, phase 3, multicentre trial. | pretreatment with anti-thymocyte globulin (atg) decreases the occurrence of chronic graft-versus-host disease (cgvhd) after haemopoietic cell transplantation from an unrelated donor, but evidence of patient benefit is absent. we did a study to test whether atg provides patient benefit, particularly in reducing the need for long-term immunosuppressive treatment after transplantation. | 2016 | 26723083 |
| levels of plasma epstein-barr virus dna prior and subsequent to treatment predicts the prognosis of nasopharyngeal carcinoma. | the level of epstein-barr virus dna (ebv-dna) in the plasma prior and subsequent to treatment is a reliable biomarker for the screening, diagnosis, monitoring and prognosis of nasopharyngeal carcinoma (npc). the present retrospective study aimed to determine whether pre- and post-treatment levels of plasma ebv-dna were predictive of survival in a large sample of patients with npc. the level of plasma ebv-dna in 637 npc patients prior and subsequent to treatment was determined by quantitative pol ... | 2015 | 26722258 |
| effects of anti-nkg2a antibody administration on leukemia and normal hematopoietic cells. | natural killer cells are key cells of the innate immune system. natural killer cell receptor repertoires are diversified by a stochastic expression of killer-cell-immunoglobulin-like receptors and lectin-like receptors such as nkg2 receptors. all individuals harbor a subset of natural killer cells expressing nkg2a, the inhibitory checkpoint receptor for hla-e. most neoplastic and normal hematopoietic cells express hla-e, the inhibitory ligand of nkg2a. a novel anti-human nkg2a antibody induced t ... | 2016 | 26721894 |
| de novo cpg methylation on an artificial chromosome-like vector maintained for a long-term in mammalian cells. | to examine whether an autonomously replicating, artificial chromosome-like vector containing a long genomic dna sequence (namely, epigenosome-nanog) undergoes de novo cpg methylation after maintenance in cultured cells for more than a half year. | 2016 | 26721236 |
| hydroa vacciniforme-like eruption associated with epstein-barr virus infection in an older adult. | 2015 | 26719662 | |
| correction for strong et al., epstein-barr virus and human herpesvirus 6 detection in a non-hodgkin's diffuse large b-cell lymphoma cohort by using rna sequencing. | 2016 | 26719559 | |
| epstein-barr virus nuclear antigen 3 (ebna3) proteins regulate ebna2 binding to distinct rbpj genomic sites. | latent infection of b lymphocytes by epstein-barr virus (ebv) in vitro results in their immortalization into lymphoblastoid cell lines (lcls); this latency program is controlled by the ebna2 viral transcriptional activator, which targets promoters via rbpj, a dna binding protein in the notch signaling pathway. three other ebna3 proteins (ebna3a, ebna3b, and ebna3c) interact with rbpj to regulate cell gene expression. the mechanism by which ebnas regulate different genes via rbpj remains unclear. ... | 2015 | 26719268 |
| epidemiology of multiple sclerosis. | multiple sclerosis (ms) is the most frequently seen demyelinating disease, with a prevalence that varies considerably, from high levels in north america and europe (>100/100,000 inhabitants) to low rates in eastern asia and sub-saharan africa (2/100,000 population). knowledge of the geographical distribution of the disease and its survival data, and a better understanding of the natural history of the disease, have improved our understanding of the respective roles of endogenous and exogenous ca ... | 2016 | 26718593 |
| prevalence of herpesvirus and correlation with clinical parameters in indian subjects with chronic periodontitis. | the identification of new uncultured species and viruses supports the possibility of combination of the herpes-virus-bacterial periodontal infection for periodontitis. the paucity of data and studies with larger sample size in indian subjects provides an unclear picture of the presence of the herpesvirus in this population. | 2015 | 26718301 |
| [lung injury associated with severe epstein-barr virus (ebv) infection]. | severe epstein-barr (eb) virus infection is potentially a devastating process that often leads to death encountered in pediatrics recently. inappropriate control of eb virus replication may cause severe infection resulting in multiple organ dysfunction. however, little information is available on pulmonary complications associated with eb virus infection. the aim of the present study was to investigate severe eb virus (ebv) infection complicated with lung injury in pediatric intensive care unit ... | 2015 | 26717656 |
| identification of novel small organic compounds with diverse structures for the induction of epstein-barr virus (ebv) lytic cycle in ebv-positive epithelial malignancies. | phorbol esters, which are protein kinase c (pkc) activators, and histone deacetylase (hdac) inhibitors, which cause enhanced acetylation of cellular proteins, are the main classes of chemical inducers of epstein-barr virus (ebv) lytic cycle in latently ebv-infected cells acting through the pkc pathway. chemical inducers which induce ebv lytic cycle through alternative cellular pathways may aid in defining the mechanisms leading to lytic cycle reactivation and improve cells' responsiveness toward ... | 2015 | 26717578 |
| genome-wide analysis of epstein-barr virus (ebv) isolated from ebv-associated gastric carcinoma (ebvagc). | epstein-barr virus (ebv) is linked to the development of a variety of malignancies, including ebv-associated gastric carcinoma (ebvagc). in this study, ebvagc was detected in 15 (7.3%) of 206 gc cases. to identify the ebv genomic variation, ebv genomic sequences isolated from 9 ebvagc biopsy specimens were successfully retrieved, designated ebvagc1 to ebvagc9. by comparative analysis of these strains with another 6 completely sequenced ebv strains, ebv-wild type, b95-8, ag876, gd1, gd2, and hknp ... | 2016 | 26716899 |
| polymerase chain reaction in unilateral cases of presumed viral anterior uveitis. | anterior uveitis is the most common form of intraocular inflammation. the main aim of this study was to determine the viral etiology in patients with unilateral cases of anterior uveitis. | 2015 | 26715836 |
| differential impact of two doses of antithymocyte globulin conditioning on lymphocyte recovery upon haploidentical hematopoietic stem cell transplantation. | in vivo depletion of host t cells with antithymocyte globulin (atg) is a common strategy for preventing graft-versus-host disease in allogeneic hematopoietic stem cell transplantation (hsct). the total dose of atg in conditioning regimens appears to be an important factor that influences the outcome in recipients of transplants. however, the optimal atg dosage has not been established to date. it remains unclear whether, in the setting of haploidentical hsct (haplohsct), different doses of atg m ... | 2015 | 26715367 |
| illuminating vitamin d effects on b cells--the multiple sclerosis perspective. | vitamin d is associated with many immune-mediated disorders. in multiple sclerosis (ms) a poor vitamin d status is a major environmental factor associated with disease incidence and severity. the inflammation in ms is primarily t-cell-mediated, but increasing evidence points to an important role for b cells. this has paved the way for investigating vitamin d effects on b cells. in this review we elaborate on vitamin d interactions with antibody production, t-cell-stimulating capacity and regulat ... | 2016 | 26714674 |
| phosphoproteomic profiling reveals epstein-barr virus protein kinase integration of dna damage response and mitotic signaling. | epstein-barr virus (ebv) is etiologically linked to infectious mononucleosis and several human cancers. ebv encodes a conserved protein kinase bglf4 that plays a key role in the viral life cycle. to provide new insight into the host proteins regulated by bglf4, we utilized stable isotope labeling by amino acids in cell culture (silac)-based quantitative proteomics to compare site-specific phosphorylation in bglf4-expressing akata b cells. our analysis revealed bglf4-mediated hyperphosphorylation ... | 2015 | 26714015 |
| extranodal natural killer/t-cell lymphoma in children and adolescents: a report of 17 cases in china. | to investigate the clinicopathologic features of extranodal natural killer/t-cell lymphoma (enktl) not preceded by another epstein-barr virus (ebv)-related disorder in children and adolescents. | 2016 | 26712870 |
| diagnostic values for the viral load in peripheral blood mononuclear cells of patients with chronic active epstein-barr virus disease. | chronic active epstein-barr virus disease (caebv) is a distinct ebv-associated lymphoproliferative disease with a poor prognosis. although the viral load in blood samples has been widely used for diagnosing caebv, well-defined viral load thresholds to guide clinicians are currently lacking. the aim of the present study was to determine standardized diagnostic values for ebv load in blood samples of caebv patients using the world health organization international standard for reporting. levels of ... | 2016 | 26712582 |
| secondary neuroendocrine tumor after allogeneic bone marrow transplantation. | here we report a case of aggressive neuroendocrine tumor (net), which is an extremely rare secondary solid tumor that occurs after allogeneic hematopoietic cell transplantation (allo-hsct). a patient with chronic active epstein-barr virus infection received allo-hsct from an hla-dr two allele-mismatched unrelated donor. four years later, he developed net with multiple metastases. he received thoraco-abdominal irradiation as a conditioning regimen, and developed repeated episodes of intestinal gr ... | 2015 | 26711919 |
| [infection status and prognostic significance analysis of epstein-barr virus in 207 cases with newly diagnosed hodgkin's lymphoma]. | to evaluate the epstein barr virus (ebv) positive rate in untreated hodgkin's lymphoma (hl) and investigate the prognostic significance of ebv status. | 2015 | 26711606 |
| [cellular immune therapy for epstein-barr virus infection after hematopoietic stem cell transplantation]. | hematopoietic stem cell transplantation is an effective method for treatment of hematologic malignancies. due to the use of immunosuppressive agents and a long time of immune restoration after transplantation, the incidence of virus infection is high. epstein-barr virus (ebv) infection is a common viral infection after transplantation. in spite of the low incidence of post transplantation lymphoproliferative disorder (ptld) caused by ebv, this disease is characte-rized by rapid progression and h ... | 2015 | 26708907 |
| determinants of ethnic differences in cytomegalovirus, epstein-barr virus, and herpes simplex virus type 1 seroprevalence in childhood. | to identify whether there are ethnic differences in cytomegalovirus (cmv), epstein-barr virus (ebv), and herpes simplex virus type 1 (hsv-1) seroprevalence rates in children at 6 years of age, and when present, to evaluate how these differences can be explained by sociodemographic and environmental factors. | 2016 | 26707579 |
| [clinicopathologic analysis of angioimmunoblastic t-cell lymphoma with hodgkin/reed-sternberg-like cells]. | to study the clinicopathologic features and pathologic diagnosis and differential diagnosis of angioimmunoblastic t-cell lymphoma with hrs-like cells. | 2015 | 26705178 |
| [epstein-barr virus-associated inflammatory pseudotumour of kidney]. | 2015 | 26704837 | |
| pediatric advanced stage nasopharyngeal carcinoma - case report. | nasopharyngeal carcinoma is an extremely rare pediatric malignancy predominantly occurring in adolescent males. its multifactorial pathogenesis is most strongly associated with the exposure to epstein-barr virus in genetically susceptible hosts. in younger patients, more aggressive biological behavior has been observed, although the overall survival is better compared to adults. due to its rarity and nonspecific clinical presentation, the diagnosis in children is often delayed and misinterpreted ... | 2015 | 26702913 |
| identification and functional analysis of the bim interactome; new clues on its possible involvement in epstein-barr virus-associated diseases. | epigenetic deregulation is a common feature in the pathogenesis of epstein-barr virus (ebv)-related lymphomas and carcinomas. previous studies have demonstrated a strong association between ebv latency in b-cells and epigenetic silencing of the tumor suppressor gene bim. this study aimed to the construction and functional analysis of the bim interactome in order to identify novel host genes that may be targeted by ebv. fifty-nine unique interactors were found to compose the bim gene network. ont ... | 2015 | 26702402 |
| epstein-barr virus mir-bart1-5p detection via nasopharyngeal brush sampling is effective for diagnosing nasopharyngeal carcinoma. | epstein-barr virus (ebv)-encoded micrornas (mirnas) are highly expressed in nasopharyngeal carcinoma (npc) cases in high-risk areas, and may be involved in tumorigenesis. using quantitative rt-pcr, we detected four ebv-encoded bamhi a rightward transcript (bart) mirnas (mir-bart1-5p, mir-bart5, mir-bart6-5p and mir-bart17-5p) exclusively in 53 npc biopsies as compared to 69 controls. in a larger patient group, that included 215 npc cases and 209 controls, significantly higher levels of all four ... | 2016 | 26701721 |
| imaging of herpesvirus infections of the cns. | herpesviridae are a family of dna viruses remarkable for their ability to both promote acute infection and enter a latent phase with potential of reactivation. herpes infections are ubiquitous throughout the human life span, regardless of the degree of immunocompetence. | 2016 | 26700334 |
| susceptibility of kshv-infected pel cell lines to the human complement system. | pleural effusion lymphoma (pel) is a rare b-cell lymphoma that has a very poor prognosis with a median survival time of around 6 months. pel is caused by kaposi's sarcoma-associated herpesvirus, and is often co-infected with the epstein barr virus. the complement system is fundamental in the innate immune system against pathogen invasion and tumor development. in the present study, we investigated the activation of the complement system in pel cells using human serum complements. interestingly, ... | 2016 | 26699745 |
| epstein-barr virus-encoded lmp1 increases mir-155 expression, which promotes radioresistance of nasopharyngeal carcinoma via suppressing ubqln1. | epstein-barr virus (ebv)-encoded latent membrane protein (lmp1) can drive aberrant expression of mir-155 in nasopharyngeal carcinoma (npc). in this study, we investigated the regulation of mir-155 expression over ubqln1 and studied their effects on radio-sensitivity of npc. | 2015 | 26698246 |
| the epstein-barr virus bart mirna cluster of the m81 strain modulates multiple functions in primary b cells. | the epstein-barr virus (ebv) is a b lymphotropic virus that infects the majority of the human population. all ebv strains transform b lymphocytes, but some strains, such as m81, also induce spontaneous virus replication. ebv encodes 22 micrornas (mirnas) that form a cluster within the bart region of the virus and have been previously been found to stimulate tumor cell growth. here we describe their functions in b cells infected by m81. we found that the bart mirnas are downregulated in replicati ... | 2015 | 26694854 |
| epstein-barr virus-induced gene 3 suppresses t helper type 1, type 17 and type 2 immune responses after trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation. | the epstein-barr virus-induced gene 3 (ebi3) is a member of the interleukin-12 (il)-12) family structurally related to the subunit p40 of il-12 and forms a heterodimer either with the p28 subunit to build il-27 or with p35 to form il-35. interleukin-27 is secreted by antigen-presenting cells whereas il-35 appears to be produced mainly by regulatory t cells and regulatory b cells but both cytokines negatively regulate inflammatory immune responses. we here analysed the function of ebi3 during inf ... | 2016 | 26694585 |
| lymphoepithelioma-like carcinoma of the urinary bladder: a rare case report. | bladder cancers are the second most common urogenital malignancy, its most common type being urothelial carcinoma. lymphoepithelioma-like carcinoma (lelc) which is commonly described in the nasopharynx is a very rare presentation in the bladder. diagnosis of this entity poses a histopathological challenge. nonetheless, the correct diagnosis is important as it implies a different therapeutic approach with the potential bladder salvage treatment protocol. we here present a case of an 87-year-old m ... | 2017 | 26692678 |
| non-human cancers in aids patients. | neoplasms are more frequent in hiv-positive persons than in non-infected individuals. the incidence of malignancies associated to oncoviruses increases with low cd4 counts in hiv carriers. this is the case for kaposi sarcoma, castleman disease or effusive cavity lymphomas due to hhv-8, anorectal or cervical cancer due to human papillomavirus, and burkitt lymphoma or large b-cell lymphoma due to epstein-barr virus. | 2015 | 26690493 |
| opportunistic dna recombination with epstein-barr virus at sites of control region rearrangements mediating jc virus neurovirulence. | we document a unique dna recombination between polyomavirus jc (jc virus [jcv]) and epstein-barr virus (ebv) at sequences of jcv found infecting the brain. archetype jcv is present in bone marrow and uroepithelial cells of most adults. during immunosuppression, jcv can infect the brain, causing a demyelinating disease, progressive multifocal leukoencephalopathy. rearrangements in the archetype noncoding control region are necessary for neurovirulence. two nccr deletions and a duplication occur a ... | 2016 | 26690342 |
| risk stratification on the basis of deauville score on pet-ct and the presence of epstein-barr virus dna after completion of primary treatment for extranodal natural killer/t-cell lymphoma, nasal type: a multicentre, retrospective analysis. | assessment of tumour viability after treatment is essential for prediction of treatment failure in patients with extranodal natural killer/t-cell lymphoma (enktl). we aimed to assess the use of the post-treatment deauville score on pet-ct and epstein-barr virus dna as a predictor of residual tumour, to establish the risk of treatment failure in patients with newly diagnosed enktl. | 2015 | 26687611 |
| successful management of ebv-ptld in allogeneic bone marrow transplant recipient by virological-immunological monitoring of ebv infection, prompt diagnosis and early treatment. | epstein-barr virus-related post-transplant lymphoproliferative disorder (ebv-ptld) is an uncommon, but frequently fatal, complication after allogeneic hematopoietic stem cell transplant. prospective post-transplant virological and immunological monitoring allowed to successfully manage a patient who developed both polymorphic and monomorphic, "diffuse large b-cell lymphoma like", as an ebv-ptld, 65days after allogeneic bone marrow transplant. early detection of significant increase in ebv dna le ... | 2016 | 26687013 |
| diversity and combinations of infectious agents in 38 adults with an infection-triggered reactive haemophagocytic syndrome: a multicenter study. | reactive haemophagocytic syndrome (hs) is a rare condition that occurs in patients with infections, haematological malignancies or autoimmune diseases. although various microorganisms are thought to trigger hs, most of the literature data on this topic have been gathered in single-centre case series. here, we sought to characterize infectious triggers in a large, multicentre cohort of patients with hs. patients were included in the present study if hs was solely due to one or more infections. de ... | 2016 | 26686809 |
| metabolic reprogramming: a hallmark of viral oncogenesis. | more than 1 in 10 cases of cancer in the world are due to chronic viral infections. viruses induce oncogenesis by targeting the same pathways known to be responsible for neoplasia in tumor cells, such as control of cell cycle progression, cell migration, proliferation and evasion from cell death and the host's immune defense. in addition, metabolic reprogramming has been identified over a century ago as a requirement for growth of transformed cells. renewed interest in this topic has emerged rec ... | 2016 | 26686092 |