Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| herpes vegetans as a sign of hiv infection. | herpes progenitalis can present in bizarre ways when seen in conjunction with altered immune status. in the recent past, a small number of individuals have been described with herpes vegetans, an exophytic, proliferative lesion that resembles either a verrucous or malignant growth. this phenomenon can occur on the digits, genitalia or perioral skin. we present a case of a vegetating penile plaque attributed to herpesvirus in an hiv-positive patient. | 2008 | 18627728 |
| prevalence and incidence of sexually transmitted infections among south indians at increased risk of hiv infection. | sexually transmitted infections (stis) have been identified as cofactors of hiv transmission. greater understanding of local sti burdens can assist in the development of more effective sti and hiv prevention strategies. the aim of this study is to determine the prevalence and incidence of stis among south indian men and women identified to be at increased risk for hiv infection. individuals at increased risk for hiv infection were enrolled in a prospective longitudinal study in chennai, india (n ... | 2008 | 18627276 |
| famciclovir treatment options for patients with frequent outbreaks of recurrent genital herpes: the relief trial. | recurrent genital hsv outbreaks are common among those suffering from the disease. antiviral medications taken as suppressive therapy can reduce the frequency of these recurrences and reduce viral shedding occurring in between recurrences. | 2008 | 18621575 |
| an immunomodulating dipeptide, scv-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (hsv-2). | herpes simplex virus type 2 (hsv-2) infections produce a recurrent disease state associated with susceptibility to other pathogens, including human immunodeficiency virus (hiv), and cannot be cured by current therapeutic treatments. the hsv-2 epidemic must therefore be addressed by therapeutic strategies that reduce recurrent lesions and ideally lack the possibility for development of drug resistance. to this end, the therapeutic potential of scv-07 (gamma-d-glutamyl-l-tryptophan), a synthetic d ... | 2008 | 18619817 |
| high diagnostic yield by csf-pcr for entero- and herpes simplex viruses and tbev serology in adults with acute aseptic meningitis in stockholm. | acute aseptic meningitis (aam) affects 10-20/100,000 inhabitants per years in sweden. up to the beginning of the 1980s the diagnoses were made by virus isolation and/or determination of viral antibodies in serum. the development of pcr for detection of viruses in csf samples has increased the sensitivity and diagnostic efficiency considerably. we investigated the aetiology of aam and the diagnostic efficiency in an adult population in stockholm, using a limited first-line combination of microbio ... | 2008 | 18615360 |
| successful kinase bypass with new acyclovir phosphoramidate prodrugs. | novel phosphoramidates of acyclovir have been prepared and evaluated in vitro against acyclovir-sensitive and -resistant herpes simplex virus (hsv) types 1 and 2 and varicella-zoster virus (vzv). unlike the parent nucleoside these novel phosphate prodrugs retain antiviral potency versus the acv-resistant virus strain, suggesting an efficient bypass of the viral thymidine kinase. | 2008 | 18614365 |
| do protective behaviors follow the experience of testing positive for herpes simplex type 2? | to test the hypothesis that individuals attending a sexually transmitted disease (std) clinic would adopt sexual protective behaviors after receiving a positive test for herpes simplex virus 2 (hsv-2). | 2008 | 18607318 |
| viral sexually transmitted infections and bacterial vaginosis: 2001-2004 national health and nutrition examination survey data. | bacterial vaginosis (bv) is a common condition believed to be associated with sexually transmitted infection (sti) susceptibility. most studies of bv and stis have come from treatment-seeking or high-risk populations. this study examines the association between 5 viral stis, human papilloma virus (hpv), hiv, herpes simplex viruses types 1 and 2 (hsv-1 and hsv-2), and hepatitis c (hcv), and bv among women in the general us population. | 2008 | 18607314 |
| herpes simplex encephalitis as an initial presentation of creutzfeldt-jakob disease. | 2008 | 18605370 | |
| neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1. | herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2) belong to the family herpesviridae, the subfamily alphaherpesvirinae, and the genus simplexvirus. they are ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. herpes simplex encephalitis (hse) is associated with a high mortality rate and significant neurological, neuropsychological, and neurobehavioral sequelae, which afflict patients for life. hsv-1 has been suggested ... | 2008 | 18599953 |
| effect of hiv-1 and antiretroviral therapy on herpes simplex virus type 2: a prospective study in african women. | to document the natural history of herpes simplex virus type 2 (hsv-2) in relation to hiv and highly active antiretroviral therapy (haart) in africa, a longitudinal study was conducted of women in the placebo arms of two randomised controlled trials of hsv-suppressive therapy in burkina faso. | 2008 | 18596069 |
| roles of clinical and subclinical reactivated herpes simplex virus type 2 infection and human immunodeficiency virus type 1 (hiv-1)-induced immunosuppression on genital and plasma hiv-1 levels. | few longitudinal studies have described the interactions between reactivation of herpes simplex virus type 2 (hsv-2) infection (hereafter, "hsv-2 reactivation") and genital and systemic replication of human immunodeficiency virus type 1 (hiv-1). | 2008 | 18593294 |
| rapidly increasing incidence of kaposi's varicelliform eruption in patients with atopic dermatitis. | 2008 | 18583798 | |
| herpes simplex virus 2 infection: a risk factor for hiv infection in heterosexuals. | genital ulcerative disease is one of the risk factors for acquisition of hiv. as hsv-2 infection is currently the most common cause of genital ulcerative disease, it acts as a potential risk factor for hiv infection. the present study was undertaken to know the seroprevalence of antibodies to hsv-2 in hiv seropositive individuals and in the general population, and to ascertain if hsv-2 is a risk factor for developing hiv infection. | 2008 | 18583789 |
| comparison of nested-polymerase chain reaction and virus culture for the diagnosis of genital herpes simplex virus infection. | this study was performed to compare nested-polymerase chain reaction (pcr) with viral culture as a diagnostic tool for genital herpes simplex virus (hsv) infection in a sexually transmitted infection (sti) clinic in singapore. | 2008 | 18581019 |
| clients of female sex workers in gonaives and st-marc, haiti characteristics, sexually transmitted infection prevalence and risk factors. | few data exist on the role of clients of female sex workers (fsws) in sti transmission. this study examined sociodemographic characteristics, risk behaviors, and sti prevalence among clients of fsws in haiti. | 2008 | 18580821 |
| acute and recurrent viral meningitis. | acute viral meningitis is the most common infection of the central nervous system. most cases occur in children and young adults and are due to enteroviruses. although the common causes of acute viral meningitis still lack treatment with an effective antiviral agent, management of patients is changing because of better and more rapid diagnostic tests to determine the exact viral etiology. these tests reduce the cost of workups and shorten hospitalizations. recurrent meningitis is less common, wi ... | 2008 | 18579020 |
| seroprevalence and risk factors associated with herpes simplex virus infection among pregnant women. | to estimate the type-specific seroprevalence and identify the risk factors associated with herpes simplex virus (hsv)-2 infection in pregnant women in bucharest, romania. | 2008 | 18576929 |
| facile biocatalytic access to 9-fluorenylmethyl polyglycosides: evaluation of antiviral activity on immunocompetent cells. | the biological activities of a series of mono- and oligosaccharides (beta-xylosides and alpha-glucosides) of 9-fluorenylmethanol were investigated together with mono-beta-galactoside and beta-glucoside of this aglycone, produced by biocatalytic routes. by using marine glycoside hydrolases and inexpensive donors such as maltose or xylan, access to mono-alpha-glucoside or mono-beta-xyloside of 9-fluorenylmethanol was obtained. additionally, interesting polyglycoside derivatives were isolated. biol ... | 2008 | 18576391 |
| inhibition of herpes simplex virus types 1 and 2 in vitro infection by sulfated derivatives of escherichia coli k5 polysaccharide. | herpes simplex virus type 1 (hsv-1) and hsv-2 are neurotropic viruses and common human pathogens causing major public health problems such as genital herpes, a sexually transmitted disease also correlated with increased transmission and replication of human immunodeficiency virus type 1 (hiv-1). therefore, compounds capable of blocking hiv-1, hsv-1, and hsv-2 transmission represent candidate microbicides with a potential added value over that of molecules acting selectively against either infect ... | 2008 | 18573926 |
| seroprevalence of sexually transmitted viruses in the tribal population of central india. | to determine the seroprevalence of human immunodeficiency virus (hiv), hepatitis b and c viruses (hbv, hcv), and herpes simplex virus type 2 (hsv-2) in the tribal population of central india. | 2009 | 18573674 |
| effect of an immune enhancer, gpi-0100, on vaccination with live attenuated herpes simplex virus (hsv) type 2 or glycoprotein d on genital hsv-2 infections of guinea pigs. | these studies were performed to determine the effect of ad-472, an attenuated human herpes simplex virus (hsv) type 2 or hsv-2 glycoprotein d (gd) when combined with an adjuvant, gpi-0100, a semi-synthetic quillaja saponin analog in a genital hsv-2 infection in guinea pigs. while animals immunized with either vaccine had reduced clinical disease, gpi-0100 only improved the efficacy of gd and did not affect the efficacy of the live vaccine. neither vaccine had any therapeutic effect if administer ... | 2008 | 18573279 |
| protein arrays based on biotin-streptavidin system for the simultaneous detection of torch infections. | in this paper, we developed a protein array based on biotin-streptavidin system (pabs) used in the identification of igm antibodies against torch antigens, including toxoplasma gondii (tox), rubella virus (ruv), cytomegalovirus (cmv) and herpes simplex virus types ii (hsv-2) antigens. the detection signal intensities and sensitivities between the pabs and the direct labeling array system (dlas) were compared. the linear ranges of detectable igm antibodies in pabs were 0.485-1000 microg/ml, which ... | 2008 | 18572639 |
| anti-herpetic activity of a sulfated xylomannan from scinaia hatei. | many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. this raises the possibility of the application of sulfated polysaccharides in antiviral therapy. in this study we have analyzed polysaccharide fractions isolated from scinaia hatei. the crude water extract (shwe) as well as one fraction (f1) obtained by size exclusion chromatography had potent anti-hsv activity. their inhibitory concentration 50% (ic50) values ranging from 0.5 t ... | 2008 | 18572208 |
| effect of aciclovir on hiv-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. | across many observational studies, herpes simplex virus type 2 (hsv-2) infection is associated with two-fold to three-fold increased risk for hiv-1 infection. we investigated whether hsv-2 suppression with aciclovir would reduce the risk of hiv-1 acquisition. | 2008 | 18572080 |
| reassessing the hypothesis on sti control for hiv prevention. | 2008 | 18572064 | |
| comparison of intramuscular and footpad subcutaneous immunization with dna vaccine encoding hsv-gd2 in mice. | herpes simplex virus type 2 is the most common infectious agent in humans that causes genital herpes disease and vaccination is a desirable method to prevent herpes infections. an effective therapeutic vaccine will need to elicit virus-specific immune responses. the route of immunization has important role in immune responses. in this study, dna vaccine encoding glycoprotein d of herpes simplex virus type 2 (hsv-gd2) was prepared and injected via intramuscular and footpad routes to determine the ... | 2009 | 18571235 |
| influenza virus infection and risk of acute myocardial infarction. | increasing evidences have shown that pathogens might promote atherosclerosis and trigger acute myocardial infarction (ami). but the conclusions from various studies on the correlation between previous influenza virus (iv) infection and ami were inconsistent. we conducted a case-control study to assess the association of previous iv infection and ami. questionnaire survey was conducted to collect information about demographic characteristics and heart disease risk factors. fasting blood sample wa ... | 2008 | 18568394 |
| comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41l in mice and guinea pigs. | a replication-defective herpes simplex virus (hsv)-2 vaccine, dl5-29, which is deleted for two essential early genes, ul5 and ul29, is highly immunogenic and protective in mice and guinea pigs. in a prior study, a derivative of hsv-2 dl5-29 termed dl5-29-41l, which has an additional deletion in ul41 (that encodes the virion-host shut-off protein), was more immunogenic and protective against challenge with wild-type hsv-2 in mice when compared with dl5-29. to determine if deletion of ul41 improve ... | 2008 | 18565628 |
| anti-herpes simplex virus (hsv-1) activity of oxyresveratrol derived from thai medicinal plant: mechanism of action and therapeutic efficacy on cutaneous hsv-1 infection in mice. | oxyresveratrol, a major compound purified from artocarpus lakoocha, a thai traditional medicinal plant, was evaluated for its mechanism of action and therapeutic efficacy on cutaneous herpes simplex virus (hsv) infection in mice. the inhibitory concentrations for 50% hsv-1 plaque formation of oxyresveratrol, three clinical isolates, thymidine kinase (tk)-deficient and phosphonoacetic acid (paa)-resistant hsv-1 were 19.8, 23.3, 23.5, 24.8, 25.5 and 21.7microg/ml, respectively. oxyresveratrol exhi ... | 2008 | 18565600 |
| prevalence of human herpes virus types 1-7 in the semen of men attending an infertility clinic and correlation with semen parameters. | to determine the prevalence of herpes viruses in the semen of an asymptomatic male cohort with and without infertility problems and its association with altered semen parameters. | 2009 | 18565516 |
| detection and quantitative analysis of human herpesvirus in pilocytic astrocytoma. | we investigated the hypothetical role of human herpesviruses (hhvs) in tumour formation of the cerebellum. thirty-five samples of pilocytic astrocytoma and 10 control samples of cerebellum from patients who died of unrelated diseases were examined. presence of the 8 known hhvs was first studied using specific real-time quantitative polymerase chain reaction (qpcr) targeting viral dna polymerase. hhv's dna polymerase was found present in 20 samples (7 controls, 13 astrocytomas) and was absent in ... | 2008 | 18565499 |
| a replication-competent, neuronal spread-defective, live attenuated herpes simplex virus type 1 vaccine. | herpes simplex virus type 1 (hsv-1) produces oral lesions, encephalitis, keratitis, and severe infections in the immunocompromised host. hsv-1 is almost as common as hsv-2 in causing first episodes of genital herpes, a disease that is associated with an increased risk of human immunodeficiency virus acquisition and transmission. no approved vaccines are currently available to protect against hsv-1 or hsv-2 infection. we developed a novel hsv vaccine strategy that uses a replication-competent str ... | 2008 | 18562543 |
| comparison of automated nucleic acid extraction methods with manual extraction. | automated nucleic acid extractors can improve workflow and decrease variability in the clinical laboratory. we evaluated qiagen ez1 (valencia, ca) and biomérieux (durham, nc) easymag extractors compared with qiagen manual extraction using targets and matrices commonly available in the clinical laboratory. pooled samples were spiked with various organisms, serially diluted, and extracted in duplicate. the organisms/matrices were bordetella pertussis/bronchoalveolar lavage, herpes simplex virus ii ... | 2008 | 18556770 |
| clinical validation of a new triplex real-time polymerase chain reaction assay for the detection and discrimination of herpes simplex virus types 1 and 2. | a new triplex real-time polymerase chain reaction (pcr) assay for herpes simplex virus (hsv) (artus hsv-1/2 tm pcr kit, qiagen) was evaluated. this assay simultaneously uses three differently labeled probes targeted to hsv-1 (fam), hsv-2 (ned), and to the manufacturer's internal control (vic). hsv-1/2 typing capability and quantitation accuracy were determined using hsv stocks and quality control panels. performance in routine clinical testing was compared with a nested hsv-1/2 pcr assay. diluti ... | 2008 | 18556766 |
| morphologic changes in fibroadenoma of breast due to chickenpox: a case report with suspicious cytology in fine needle aspiration smears. | fibroadenomas with stromal giant cell reaction have been described in the literature, but cytologic atypia including giant cell reaction due to chickenpox giving rise to suspicious cytology has not been reported. | 2008 | 18540301 |
| glycosaminoglycans are not indispensable for the anti-herpes simplex virus type 2 activity of lactoferrin. | lactoferrin has been recognized as a potent inhibitor of human herpetic viruses, such as herpes simplex type 1 (hsv-1) and 2 (hsv-2). in particular, bovine lactoferrin (blf) has been found to prevent viral infection by binding to heparan sulphate (hs) glycosaminoglycans (gags) that in turn can act as cell receptors for human herpetic viruses. in this study we further investigate the mechanism of inhibiting activity of both human lactoferrin (hlf) and blf against hsv-2. the antiviral effect of th ... | 2009 | 18534197 |
| prevalence of hsv-2 antibody in a melbourne antenatal population attending a tertiary obstetric hospital. | to determine the herpes simplex virus 2 (hsv-2) seroprevalence rate in a melbourne antenatal cohort. | 2008 | 18532957 |
| maternal herpes simplex virus type 2 coinfection increases the risk of perinatal hiv transmission: possibility to further decrease transmission? | to evaluate the association between maternal herpes simplex virus type 2 seropositivity and genital herpes simplex virus type 2 shedding with perinatal hiv transmission. | 2008 | 18525263 |
| herpes simplex virus type 2 displays atypical melting-temperature profiles at low viral titers. | real-time pcr is a powerful tool for the detection and typing of herpes simplex virus (hsv). hsv types 1 and 2 can be distinguished by using the differences in the melting temperatures (t(m)s) of the hybridization probes. the efficacy of t(m) profiling with low dna concentrations was evaluated in this study. | 2008 | 18524967 |
| herpes simplex virus type 2 trends in relation to the hiv epidemic in northern malawi. | it is unclear whether the high prevalence of herpes simplex virus type 2 (hsv-2) found in much of africa predates the hiv epidemic or is, to some extent, a consequence of it. hsv-2 prevalence trends in a rural african community were assessed over a period in which hiv prevalence rose sharply, and antenatal clinic (anc) surveillance was explored as a method of estimating community hsv-2 prevalence. | 2008 | 18524842 |
| efficient amplification with nasba of hepatitis b virus, herpes simplex virus and methicillin resistant staphylococcus aureus dna. | a new mechanism is described for dna amplification using nucleic acid sequence-based amplification (nasba) including a restriction enzyme digestion and p1 primer binding directly upstream of the digestion. for hepatitis b virus (hbv), herpes simplex virus (hsv) and methicillin resistant staphylococcus aureus (mrsa) dna, which all show very poor amplification with normal nasba, assay sensitivity was improved by a factor 100-1000 when restriction enzyme digestion was performed prior to amplificati ... | 2008 | 18514336 |
| hiv-1, hsv-2 and syphilis among pregnant women in a rural area of tanzania: prevalence and risk factors. | evidence suggests that a substantial proportion of new hiv infections in african countries are associated with herpes simplex virus type 2 (hsv-2). thus, the magnitude of hsv-2 infection in an area may suggest the expected course of the hiv epidemic. we determined prevalence of genital herpes, syphilis and associated factors among pregnant women from a remote rural tanzanian community that has a low but increasing hiv prevalence. | 2008 | 18513451 |
| comparison of three commercial immunoassays for detection of herpes simplex virus type 2 antibodies in commercial sex workers in yunnan province, china. | five hundred commercial sex workers in china were tested for herpes simplex virus type 2 by three immunoassays and western blotting. sensitivities for the focus, kalon, and biokit assays were 86.7%, 82.3%, and 34.9%, respectively, and specificities were 91.8%, 94.2%, and 60.1%, respectively. the focus assay performed optimally at an index of 1.5 (95.2% sensitivity and 93.4% specificity), and the kalon assay performed optimally at an index of 1.2 (93.3% sensitivity and 95.2% specificity). | 2008 | 18508932 |
| expression of the herpes simplex virus type 2 glycoprotein d in baculovirus expression system and evaluation of its immunogenicity in guinea pigs. | herpes simplex virus type 2 (hsv-2) is highly prevalent and major cause of genital herpes in humans. the life-long nature of infection and the increasing prevalence of genital herpes imply that vaccination is the best strategy for controlling the spread of infection and limiting hsv disease. hsv glycoprotein d (gd) is one of the most important viral immunogen which has an essential role in virus infectivity and induction of immune responses. | 2008 | 18506211 |
| amphipathic dna polymers exhibit antiherpetic activity in vitro and in vivo. | phosphorothioated oligonucleotides have a sequence-independent antiviral activity as amphipathic polymers (aps). the activity of these agents against herpesvirus infections in vitro and in vivo was investigated. the previously established sequence-independent, phosphorothioation-dependent antiviral activity of aps was confirmed in vitro by showing that a variety of equivalently sized homo- and heteropolymeric ap sequences were similarly active against herpes simplex virus type 1 (hsv-1) infectio ... | 2008 | 18505857 |
| detection of hsv type-1 and type-2 igg using an in vitro pca based homogeneous immunoassay. | enzyme immunoassays (eias) are widely used in the clinical laboratory and research institutes for the detection of biologically relevant analytes. almost all eias are heterogeneous in nature and require multiple steps of process. in contrast, homogeneous immunoassays (ha) offer a simplified one-step approach with a number of potential advantages over contemporary heterogeneous eias such as higher throughput and greater clinical utility. utilizing tem-1 beta-lactamase as a reporter enzyme, we hav ... | 2008 | 18503749 |
| icp10pk inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin mpp+. | apoptosis is a widely accepted component of the pathogenesis of parkinson's disease (pd), a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. however, additional death programs were implicated, and current understanding of the cycle of intracellular events that leads to the demise of these neuron jis limited. gene therapy strategies were proposed to inhibit apoptosis, but they have met with relatively limited success. here we report th ... | 2008 | 18496573 |
| [mutational pressure in genomes of alphaherpesviruses infecting human]. | genomes of the herpes simplex viruses are extremely enriched with gc. elevated g+c level in genomes of the simplex viruses is a result of their long-term evolution under the influence of the mutational pressure. we counted the rates of nucleotide substitutions from gene coding major capsid protein (mcp) (g+c = 0.68, 3gc = 0.89) of human simplex virus 1 (hsv-1) to the mcp gene (g+c = 0.70, 3gc = 0.91) of hsv-2 (the first pair of genes) and from the same mcp gene of hsv-1 to the homologous gene (g ... | 2008 | 18488448 |
| herpes simplex virus seroprevalence among children, adolescents and adults in greece. | the aim was to study the type-specific seroprevalence of herpes simplex virus (hsv)-1 and hsv-2 infections and the associated risk factors in children, adolescents and adults in greece. a total of 1867 serum samples from children, adolescents and adults of both genders aged from 0 to 60 years were collected from three large hospital-referral centres in athens. all sera were tested for type-specific antibodies to hsv-1 and hsv-2 using herpeselect igg elisa tests (focus diagnostics cypress, cal, u ... | 2008 | 18482949 |
| cervical antibodies to herpes simplex virus proteins in pregnancy and puerperium: a pilot study. | this study was undertaken to evaluate the changes in total and anti-herpes simplex virus (hsv)-specific cervical iga and igg antibody profiles during and after pregnancy. | 1996 | 18476057 |
| correction: effect of copper acyclovir complexes on herpes simplex virus type 1 and type 2 (hsv-1, hsv-2) infection in cultured cells. | 1998 | 18475863 | |
| effect of copper acyclovir complexes on herpes simplex virus type 1 and type 2 (hsv-1, hsv-2) infection in cultured cells. | we have found that when copper, zinc or cobalt is bound to a suitable ligand, the appropriate complex exhibited a significant anti-hsv effect (varadinova et al., 1993; 1996). recently published data by sagripanti et al. (1997) also show that the inhibition of hsv by copper was enhanced by reducing agents and that mechanism of the inactivation is similar as for copper-mediated dna damage (aruoma, et al. 1991; dizdaroglu, et al., 1991; toyokuni and sagripanti, 1994). therefore it was interesting t ... | 1998 | 18475820 |
| rapid immunoassay for the detection of genital herpes infection. | we evaluated a new affinity membrane strip test for the diagnosis of herpetic genital infections. test strip results, which are available by immunoassay in 30 min without the need for special equipment, were compared with the results of viral culture. | 1994 | 18475363 |
| neurological complications of herpes simplex virus type 2 infection. | herpes simplex virus type 2 (hsv-2) infection is responsible for significant neurological morbidity, perhaps more than any other virus. seroprevalence studies suggest that as many as 45 million people in the united states have been infected with hsv-2, and the estimated incidence of new infection is 1 million annually. substantial numbers of these persons will manifest neurological symptoms that are generally, although not always, mild and self-limited. despite a 50% genetic homology between hsv ... | 2008 | 18474734 |
| herpes simplex virus viremia during primary genital infection. | primary genital herpes simplex virus (hsv) infection is commonly associated with systemic symptoms. a systematic evaluation of hsv viremia during primary genital infection has not been performed previously. plasma samples from adults with a first clinical episode of genital hsv infection were assayed for hsv dna by polymerase chain reaction. one hundred sixty-four adults had confirmed primary genital hsv infection. of these, 40 (24%) had hsv dna detected in plasma. thirty-seven (93%) of 40 were ... | 2008 | 18471083 |
| core group approach to identify college students at risk for sexually transmitted infections. | to analyze the core group for sexually transmitted infections (sti) among college students. | 2008 | 18470365 |
| uracil-dna glycosylase (ung) influences the melting temperature (t(m)) of herpes simplex virus (hsv) hybridization probes. | prior to pcr amplification, uracil-dna glycosylase (ung) can be incorporated to prevent amplicon contamination. melting temperature (t(m)) analysis of herpes simplex virus (hsv) hybridization probes was used to demonstrate a concentration-dependent decrease in t(m) values when heat stabile or heat labile ung was added. | 2008 | 18468698 |
| [removal of intrauterine device possible cause of herpes simplex infection. liver affection and thrombocytopenia in an immunocompetent woman]. | 2008 | 18461856 | |
| prevalence of, and risk factors for kaposi's sarcoma-associated herpesvirus infection among blood donors in brazil: a multi-center serosurvey. | kaposi's sarcoma-associated herpesvirus (kshv) is endemic in the amazon and rare in southern regions of brazil. however, geographical distribution and epidemiological correlates of infection in this large country are still poorly defined. to estimate the seroprevalence of, and risk factors for, kshv infection in brazil, a multi-center study was conducted among 3,493 first-time voluntary unpaid blood donors from salvador, sao paulo and manaus. antibodies against kshv were detected using a whole-v ... | 2008 | 18461622 |
| oral mucosal reactivation rates of herpesviruses among hiv-1 seropositive persons. | herpes simplex virus, cytomegalovirus and epstein-barr virus infections are prevalent among hiv-1 infected persons. the relationships between salivary shedding of these herpesviruses have not been characterized. salivary samples were collected on a median of 61 consecutive days from 41 hiv-1 seropositive persons and tested for hsv-1, hsv-2, cmv and ebv. hsv was detected on 5%, cmv on 19% and ebv on 71% of the days of sampling. hsv shedding was not related to cmv or ebv shedding rates. persons wi ... | 2008 | 18461621 |
| an international, randomized, double-blind, placebo-controlled, study of valacyclovir for the suppression of herpes simplex virus type 2 genital herpes in newly diagnosed patients. | antiviral suppressive therapy of genital herpes is often initiated based on the established pattern of recurrences in an individual. because most persons with first episode herpes simplex virus type 2 (hsv-2) infection experience recurrences and because viral shedding occurs frequently in the first year after infection, we examined the strategy of initiating suppressive therapy shortly after diagnosis of genital hsv-2 infection. | 2008 | 18461016 |
| risk factors for incident herpes simplex type 2 virus infection among women attending a sexually transmitted disease clinic. | to estimate the incidence of herpes simplex type 2 virus (hsv-2) infection, to identify risk factors for its acquisition, and to assess the protective effect of condoms. | 2008 | 18461012 |
| inhibition of hsv cell-to-cell spread by lactoferrin and lactoferricin. | the milk protein lactoferrin (lf) has multiple functions, including immune stimulation and antiviral activity towards herpes simplex virus 1 and 2 (hsv-1 and hsv-2); antiviral activity has also been reported for the n-terminal pepsin-derived fragment lactoferricin (lfcin). the anti-hsv mode of action of lf and lfcin is assumed to involve, in part, their interaction with the cell surface glycosaminoglycan heparan sulfate, thereby blocking of viral entry. in this study we investigated the ability ... | 2008 | 18456345 |
| understanding herpes simplex virus: transmission, diagnosis, and considerations in pregnancy management. | genital herpes simplex virus (hsv) infections are frequently asymptomatic or undiagnosed, but more than half the us population is seropositive for hsv, and about one-fifth are positive for hsv-2. these two factors contribute to the risk for sexual transmission and therefore to the risk of late-pregnancy acquisition of hsv. most neonatal herpes infections are the result of undiagnosed, new-onset hsv infection in the mother. this article reviews the epidemiology of hsv, risks of transmission, and ... | 2008 | 18455094 |
| breaking the cycle of infection: torch and other infections in women's health. | 2008 | 18455090 | |
| [structure and antiviral activity of an acidic polysaccharide from an edible blue-green alga, nostoc flagelliforme]. | recently, the development of antiviral agents with novel mechanisms of action has been required since many types of infectious disease have become a serious problem in our society. in the present study, we isolated a novel acidic polysaccharide, nostoflan (nsf), from a terrestrial blue-green alga, nostoc flagelliforme, and examined its structure and antiviral activity. the sugar composition and methylation analyses of nsf revealed that it is mainly composed of (-->4)- d-glcp-(1-->, -->6,4)-d-glc ... | 2008 | 18451619 |
| evaluation of anti-hsv-2 activity of gallic acid and pentyl gallate. | the synthetic n-alkyl esters of gallic acid, also known as gallates, are widely employed as antioxidants by food and pharmaceutical industries. besides the antioxidant activity, other biological activities have been described for this group of molecules, mainly anticancer, antibacterial and antifungal properties. in the present study, the anti-herpes simplex virus (hsv)-2 activity of gallic acid and pentyl gallate was evaluated followed by the determination of the site of antiviral activity of t ... | 2008 | 18451516 |
| prevalence and correlates of bacterial vaginosis among young women of reproductive age in mysore, india. | bacterial vaginosis (bv) is the most common cause of abnormal vaginal discharge among women of childbearing age and is associated with sti/hiv and adverse birth outcomes. the objective of this study was to determine the prevalence and correlates of bv among young women of reproductive age in mysore, india. | 2008 | 18445948 |
| coinfection with herpes simplex virus type 2 is associated with reduced hiv-specific t cell responses and systemic immune activation. | chronic coinfection with herpes simplex virus type 2 (hsv-2) and human immunodeficiency virus (hiv) has been associated with an increased hiv viral load and more rapid disease progression, perhaps related to hsv-2-associated alterations in host immunity. | 2008 | 18444797 |
| recombinant listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2. | recombinant listeria monocytogenes expressing a type-common herpes simplex virus (hsv) gb-peptide was shown previously to protect against footpad inoculation with hsv-1. we tested this construct for protection against vaginal challenge with hsv-2. primed mice demonstrated strong recall responses, had modest reductions in hsv-2 dna in vaginal mucosa, but were not protected from disease. | 2008 | 18443737 |
| highlights of the 15th conference on retroviruses and opportunistic infections. hiv testing and prevention strategies. | a number of presentations at the 15th conference on retroviruses and opportunistic infections focused on approaches to identify hiv-infected persons for early referral to treatment and prevention. this year's conference also highlighted the challenges we face in developing effective biomedical preventions, with reports on the failure of a candidate hiv vaccine and chronic herpes simplex virus type 2 suppression to prevent hiv acquisition, and the failure of male circumcision for hiv-seropositive ... | 2008 | 18441378 |
| bilateral macular scars following intrauterine herpes simplex virus type 2 infection. | neonatal herpetic infection is uncommon, with an estimated incidence of 1 in 3000 to 20,000 births. ocular involvement most commonly consists of blepharoconjunctivitis or keratitis. we present a further manifestation of congenital herpes simplex virus (hsv) 2 infection. | 2008 | 18440255 |
| challenges in designing a taqman-based multiplex assay for the simultaneous detection of herpes simplex virus types 1 and 2 and varicella-zoster virus. | to optimise molecular detection of herpesviruses an internally controlled multiplex taqman-pcr for the detection of herpes simplex virus 1 (hsv1), herpes simplex virus 2 (hsv2) and varicella-zoster virus (vzv) was developed. the selection of the dye combination working on the abi 7700 cycler for this multiplex pcr revealed crosstalk phenomena between several combinations of reference dyes and reporter dyes. a final dye combination with cy5 as reference dye and fam/joe/txr as reporter dyes was se ... | 2008 | 18439871 |
| multi-antigenic dna immunization using herpes simplex virus type 2 genomic fragments. | a novel dna vaccine was generated using genomic fragments of a pathogen as the source of both the antigen coding and regulatory regions. the constructs, termed subgenomic vaccines (sgvs), incorporated genomic dna sequences up to 45 kbp that encompass 15-20 different genes. the sgvs were developed to generate vaccines capable of expressing multiple genes from a single construct, which could be of great benefit for commercialization. the unique feature of the sgvs is that genes are expressed from ... | 2008 | 18438102 |
| coordination of early protective immunity to viral infection by regulatory t cells. | suppression of immune responses by regulatory t cells (tregs) is thought to limit late stages of pathogen-specific immunity as a means of minimizing associated tissue damage. we examined a role for tregs during mucosal herpes simplex virus infection in mice, and observed an accelerated fatal infection with increased viral loads in the mucosa and central nervous system after ablation of tregs. although augmented interferon production was detected in the draining lymph nodes (dlns) in treg-deprive ... | 2008 | 18436744 |
| [herpes serology for genital herpes]. | the epidemiology of genital herpes is changing. the seroprevalence of hsv-2 infections is increasing, while hsv-1 is an increasingly common cause of herpetic ulcerations. the reference examination provides direct diagnosis after viral isolation in a cell culture or genome amplification. herpes serology is indicated principally if direct examination is negative and in the absence of lesions. non-type-specific serology detects antibodies common to hsv-1 and hsv-2. its specificity and sensitivity a ... | 2008 | 18436423 |
| dna microarray technology for simultaneous detection and species identification of seven human herpes viruses. | the aim of the study was to develop a multiplex pcr-based dna microarray technology for simultaneous detection and species identification of seven human herpes viruses, namely herpes simplex virus type 1, type 2 (hsv-1, hsv-2), varicella-zoster virus (vzv), epstein-barr virus (ebv), cytomegalovirus (cmv), and human herpes virus 6 (hhv-6a, hhv-6b), and to apply this technology to accurate diagnosis of herpesvirus-associated diseases. primers and oligonucleotide probes were designed and synthesize ... | 2008 | 18428126 |
| herpesvirus prevalence and viral load in healthy blood donors by quantitative real-time polymerase chain reaction. | after primary infection, human herpesviruses (hhvs) maintain long-term latent persistence, often punctuated years later by sporadic episodes of symptomatic lytic activation. also, blood-borne herpesvirus from healthy persistently infected blood donors can lead to active primary infection of immunocompromised transfusion recipients. | 2008 | 18422852 |
| a systematic review of the incidence of sensorineural hearing loss in neonates exposed to herpes simplex virus (hsv). | to develop evidence-based guidelines for appropriate audiological monitoring of children born following exposure to or infection with herpes simplex virus (hsv) for development of immediate or delayed-onset of sensorineural hearing loss (snhl). | 2008 | 18420284 |
| [applying the dna diagnostics in patients with superficial keratitis of viral origin]. | the authors evaluate the significance of the dna diagnostics in patients with superficial keratitis of viral origin and their capability to be used for monitoring of the treatment effectiveness in the follow-up. the presence of herpes simplex virus 1 and 2, varicella zoster virus (hsv 1, hsv 2, vzv), and adenoviruses was assessed by means of the dna analysis. | 2008 | 18419101 |
| seroprevalence of herpes simplex virus type 2 and characteristics associated with undiagnosed infection: new york city, 2004. | herpes simplex virus type 2 (hsv-2) infection is associated with substantial morbidity and increased risk for human immunodeficiency virus acquisition. we describe hsv-2 seroprevalence in adult new yorkers, and examine the relationship between select characteristics, infection, and diagnosis. | 2008 | 18418295 |
| hiv, the clustering of sexually transmitted infections, and sex risk among african american women who use drugs. | african american women have high rates of most sexually transmitted infections (stis), including hiv. stis have been associated with increased hiv transmission risk. | 2008 | 18418289 |
| widespread unilateral pain associated with herpes simplex virus infections. | we describe a patient group with unexplained widespread pain on one side of the body and pain exacerbations during active labial or genital herpes and during herpetic central nervous system infections. the patients had no visible lesion of the central nervous system on magnetic resonance imaging or abnormality in electrophysiological studies. to understand the nature of the pain and its possible relation to herpes simplex virus (hsv) infections, a clinical neurological examination was performed ... | 2008 | 18417422 |
| replication-defective virus vaccine-induced protection of mice from genital herpes simplex virus 2 requires cd4 t cells. | replication-defective herpes simplex virus 2 (hsv-2), used as an immunization strategy, protects against hsv-2 challenge in animal models. the roles of replication-defective virus-induced t cell subsets in control of hsv-2 infection have not been established. mice lacking b cells (micromt) were immunized, depleted of cd4 or cd8 t cells, and then challenged intravaginally with hsv-2 to elucidate t cell subset contributions in the absence of virus-specific antibody. immunized, cd4-depleted micromt ... | 2008 | 18410949 |
| regression of herpes viral infection symptoms using melatonin and sb-73: comparison with acyclovir. | infection with herpes simplex virus type 1 (hsv-1) typically causes lesions of the mouth, face, skin, esophagus, or brain. herpes simplex virus type 2 (hsv-2) usually causes infections of the genitals, rectum, skin, hands, or meninges. the herpes viruses are a major cause of blindness from keratitis. the usual drugs used for herpes are vidarabine, acyclovir, penciclovir and ganciclovir; they are associated with several complications. the aim of this study was to investigate if a formulation cont ... | 2008 | 18410585 |
| use of multiplex pcr and real-time pcr to detect human herpes virus genome in ocular fluids of patients with uveitis. | to measure the genomic dna of human herpes viruses (hhv) in the ocular fluids and to analyse the clinical relevance of hhv in uveitis. | 2008 | 18408082 |
| challenges to hiv prevention--seeking effective measures in the absence of a vaccine. | 2008 | 18403764 | |
| microarray analysis of transcriptional responses to infection by herpes simplex virus types 1 and 2 and their us3-deficient mutants. | herpes simplex virus types 1 (hsv-1) and 2 (hsv-2) induce similar responses in infected cells and animals but differ in several significant respects. previous studies have shown that defects in the us3-encoded protein kinase greatly affect both viruses in their interactions with cells and hosts. to investigate the impact of infection with hsv-1, hsv-2 and their us3-deficient mutants (deltaus3) on cellular transcriptional responses, we performed a global microarray analysis on human epithelial he ... | 2008 | 18403238 |
| low seroprevalence of herpes simplex virus type 2 among pregnant women in senegal. | herpes simplex virus type 2 (hsv-2) is considered as a major co-factor of both sexual transmission and acquisition of the human immunodeficiency virus (hiv). the hiv epidemic in senegal is characterized by a remarkable and stable low prevalence. whether hsv-2 may also constitute a possible co-factor favouring the spreading of hiv epidemic in senegal is yet unknown. this prompted us to evaluate the hsv-2 seroprevalence in the sentinel population of pregnant women in senegal. two hundred and sixty ... | 2008 | 18397553 |
| viral reactivation is not related to septic complications after major surgical resections. | anastomotic leakage and septic complications are the most important determinants of postoperative outcome after major surgical resections. malignant diseases and surgical trauma can influence immune responses and the ability to react against infectious factors, such as bacteria and viruses. comparable immune suppression can cause viral reactivation in transplantation and trauma patients. in this prospective study, patients who underwent major surgical resections for oesophageal or pancreatic can ... | 2008 | 18397464 |
| herpes simplex type 1 versus herpes simplex type 2 in anogenital herpes; a 10 year study from the waikato region of new zealand. | to determine the proportion of herpes simplex type 1 vs herpes simplex type 2, as a cause of anogenital herpes in the waikato region. we specifically looked for changes in the proportions over time, and for gender or age group associations. | 2008 | 18392061 |
| geographic prevalence and multilevel determination of community-level factors associated with herpes simplex virus type 2 infection in chennai, india. | herpes simplex virus type 2 (hsv-2) is one of the most prevalent sexually transmitted infections, and it increases the risk of transmission of human immunodeficiency virus type 1 at least twofold. individual-level factors are insufficient to explain geographic and population variation in hsv-2, suggesting the need to identify ecologic factors. the authors sought to determine the geographic prevalence and community-level factors associated with hsv-2 after controlling for individual-level factors ... | 2008 | 18388348 |
| anti-herpesvirus activities of pseudomonas sp. s-17 rhamnolipid and its complex with alginate. | the rhamnolipid biosurfactant ps-17 and its complex with the polysaccharide alginate, both produced by the pseudomonas sp. s-17 strain, were studied for their antiviral activity against herpes simplex virus (hsv) types 1 and 2. they significantly inhibited the herpesvirus cytopathic effect (cpe) in the madin-darby bovine kidney (mdbk) cell line. the investigations were carried out according to the cpe inhibition assay protocol. the suppressive effect of the compounds on hsv replication was dose- ... | 2008 | 18386492 |
| performance of herpeselect and kalon assays in detection of antibodies to herpes simplex virus type 2. | the performances of commercial enzyme-linked immunosorbent assays (elisas) in detecting herpes simplex virus type 2 (hsv-2) antibodies have been inconsistent for african and human immunodeficiency virus (hiv)-positive populations. we compared the performances of the herpeselect and kalon glycoprotein g2 elisas for patients with genital ulcer disease in ghana and the central african republic. sera from 434 women were tested with the herpeselect assay, and a subsample (n = 199) was tested by the k ... | 2008 | 18385443 |
| modelling the cost per ulcer treated of incorporating episodic treatment for hsv-2 into the syndromic algorithm for genital ulcer disease. | the proportion of genital ulcer disease (gud) due to herpes simplex virus type-2 (hsv-2) has increased in sub-saharan africa. the most recent 2003 who syndromic gud algorithm includes antiviral treatment for hsv-2 for anyone with "typical" symptoms/signs, and suggests that all gud patients receive treatment for hsv-2 in settings where hsv-2 gud aetiology is greater than 30%. the previous algorithm (1994) only targeted haemophilus ducreyi (hd) and treponema pallidum (tp). | 2008 | 18385226 |
| the burden of asymptomatic sexually transmitted infections among men in carletonville, south africa: implications for syndromic management. | to determine the prevalence of sexually transmitted infections (sti) and hiv among men attending an outreach sti/hiv screening service in informal settlements in south africa over a 3-month period. | 2008 | 18385225 |
| detection of herpesvirus dna in cerebrospinal fluid and correlation with clinical symptoms. | novel pcr techniques can detect minute quantities of herpesvirus dna in cerebrospinal fluid (csf). the clinical significance of such findings is not always clear. | 2008 | 18379728 |
| triptans: actions and reactions. | subcutaneous sumatriptan is superior to placebo in achieving headache relief. some commonly reported adverse events are paresthesias, tingling, and transient worsening of headache. why do patients develop these symptoms? our unique case may shed light on its actions. | 2008 | 18377383 |
| the continuing evolution of antiviral therapy for recurrent genital herpes: 1-day patient-initiated treatment with famciclovir. | increased understanding of the clinical and virological characteristics of recurrent genital herpes simplex virus infection in healthy adults, recognition of the critical importance of early initiation of therapy, which is best achieved by self-initiated therapy, and an appreciation of the excellent tolerance and safety of relatively high doses of available antiviral drugs have facilitated refinements to treatment regimens that are more convenient as well as efficacious and well-tolerated. this ... | 2007 | 18371288 |