Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [inflammatory pulmonary lesions: resolutions and residuals (author's transl)]. | there are different patterns of development and resolution of inflammatory alveolar and interstitial pulmonary lesions. delayed resolution of peripheral pneumonia results in lung shrinkage mainly towards the mediastinum and the apices with distortion and atypical distribution of pulmonary vasculature and compensatory hyperinflation. resolution in perivascular and peribronchial parts is often delayed and results in scarring. interstitial pneumonia may result directly in pulmonary fibrosis with lo ... | 1978 | 309140 |
| combined activitiy of clavulanic acid and ticarcillin against ticarcillin-resistant, gram-negative bacilli. | fifty-one clinical isolates of ticarcillin-resistant, gram-negative bacilli were tested for susceptibility to combinations of ticarcillin and clavulanic acid (brl 14151), a potent beta-lactamase inhibitor. minimal inhibitory concentrations (mics) were measured by a microdilution method, and minimal bactericidal concentrations for selected strains were measured by the broth dilution method. ticarcillin mics were >/=128 mug/ml for all and >/=512 mug/ml for 38 (75%) of the strains. thirty-nine stra ... | 1978 | 308792 |
| [acute hemorrhagic enteritis with klebsiella oxytoca]. | 1978 | 308552 | |
| [the position of antibiotic prevention in surgery]. | the importance of antibiotic prophylaxis for surgery: the current state of the discussion of the benefits and dangers of antibiotic prophylaxis in surgery is critically considered with reference to the literature and our own investigations. situations where prophylactic administration of antibiotics may be absolutely locigal and where such administration may be without benefit to the patient or even dangerous are commented on. "shortterm prophylaxis" where antibiotics are given before, during an ... | 1978 | 305531 |
| [x-ray pictures of various pneumonias]. | 1977 | 303738 | |
| pulmonary infections. | 1977 | 303732 | |
| comparison of in vitro activity of cephalexin, cephradine, and cefaclor. | inhibitory activity of cephalexin, cephradine, and cefaclor was compared by the who-ics agar dilution technique. cefaclor was substantially more active against staphylococci, streptococci, gonococci, meningococci, haemophilus, escherichia coli, klebsiella pneumoniae, citrobacter diversus, proteus mirabilis, salmonellae, and shigellae than was cephalexin, which in turn was more active than cephradine. cefaclor appeared to be less resistant to staphylococcal penicillinase than did the other two ag ... | 1977 | 301005 |
| enhancement of certain biological activities of muramyl dipeptide derivatives after conjugation to a multi-poly(dl-alanine)--poly(l-lysine) carrier. | n-acetylmuramyl-l-ala-d-glu-nh2 (muramyl dipeptide) and several of its derivatives are effective immunoactivators that can enhance nonspecific resistance to infection but can also elicit fever. in contrast, one of its stereoisomers, n-acetylmuramyl-d-ala-d-glu-nh2, is devoid of both these activities. our present report demonstrates that macromolecularization of muramyl dipeptide by attachment of several units to a multi-poly(dl-ala)-poly(l-lys) carrier potentiates both its pyrogenic and its immu ... | 1979 | 293743 |
| klebsiella osteoarthritis in prematurity; complication of umbilical artery catheterization. | 1979 | 293533 | |
| intergeneric mobilization of rhizobium nif genes to agrobacterium and klebsiella. | 1979 | 290853 | |
| klebsiella in patients with denture stomatitis. | 1979 | 282912 | |
| gentamicin and amikacin---an in vitro comparison using 1000 clinical isolates. | the in vitro antimicrobial activities of gentamicin and amikacin against 1000 bacterial isolates from clinical material were compared. the minimum inhibitory concentrations were determined by an agar dilution technique. both of these aminoglycoside antibiotics had a similar spectrum of activity, being highly active against most species of aerobic gram negative bacilli. gentamicin was more active than amikacin against most species of enterobacteria, haemophilus influenzae and staphylococcus aureu ... | 1978 | 282852 |
| [gas producing intramuscular abscess in two patients with acute leukemia (author's transl)]. | 1978 | 279721 | |
| susceptibility of various microorganisms to chlorhexidine. | the susceptibility to chlorhexidine of bacteria in aerobic, facultatively anaerobic and anaerobic isolates from clinical specimens of wounds, urine, saliva, and dental plaque was studied. agar diffusion tests using 50 microng chlorhexidine discs and agar dilution tests were performed and the mic values correlated with inhibition zone diameters. anaerobic plaque strains were isolated and tested by the agar dilution method in an anaerobic glove box. regression lines obtained for five agar media de ... | 1977 | 266752 |
| a safer place for patients. | 1979 | 260005 | |
| comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo. | the antibacterial activities of three aminopenicillins ampicillin, epicillin and amoxycillin were compared in vitro and in vivo. the minimum inhibitory concentrations (mic) of the three penicillins were very similar and the compounds were active against non-beta-lactamase-producing strains of escherichia coli, salmonella and shigella species, proteus mirabilis, haemophilus influenzae and neisseria gonorrhoeae. streptococci including streptococcus faecalis, and non-beta-lactamase-producing staphy ... | 1979 | 256524 |
| continuous infusion tobramycin combined with carbenicillin for infections in cancer patients. | the cure rate of infections in cancer patients is adversely affected by neutropenia (less than 1,000/mm3). in particular, patients with severe neutropenia (less than 100/mm3) have shown a poor response to antibiotics. to overcome the adverse effects of neutropenia, tobramycin was given by continuous infusion and combined with intermittent carbenicillin. tobramycin was given to a total daily dose of 300 mg/m2 and carbenicillin was given at a dose of 5 gm every four hours. there were 125 infectiou ... | 1979 | 256433 |
| asepsis in pulmonary care: improving old traditions. | 1979 | 255565 | |
| [antibiotic therapy, intestinal microbial pullulation and risk of infection in children]. | the effect of antibiotic therapy on the intestinal flora was studied qualitatively and quantitatively in 41 infants. the results have been compared with 27 normal children of the same age and background. antibiotics were responsible for the suppression of sensitive strains and for their replacement by resistant organisms but above all to a rapid multiplication of the intestinal flora. colistin and pristinamycin caused these changes when given orally. ampicillin when given both orally and parente ... | 1978 | 255089 |
| comparative evaluation of piperacillin in vitro. | the minimal inhibitory concentrations of piperacillin and seven other betalactam antibiotics were determined against 407 bacterial isolates. piperacillin was found to be more active than ampicillin against susceptible gram-negative bacilli and more active than either carbenicillin or ticarcillin against pseudomonas aeruginosa and streptococci. although piperacillin was active against klebsiella pneumoniae, this activity was less than that of the cephalosporins. piperacillin was not active agains ... | 1978 | 253573 |
| hr 756, a highly active cephalosporin: comparison with cefazolin and carbenicillin. | hr 756, a new parenteral cephalosporin, was compared with cefazolin and carbenicillin for activity against a total of 264 strains of pseudomonas aeruginosa, escherichia coli, klebsiella spp., proteus mirabilis, proteus spp. (indole positive), enterobacter spp., salmonella typhi, serratia marcescens, providencia stuartii, and staphylococcus aureus. in every comparison, except that with the last organism, hr 756 was clearly more active than cefazolin and carbenicillin. all three compounds had simi ... | 1978 | 253572 |
| antibacterial activity of apalcillin (pc-904) against gram-negative bacilli, especially ampicillin-, carbenicillin-, and gentamicin-resistant clinical isolates. | apalcillin (pc-904) is active against carbenicillin- and ampicillin-resistant strains of gram-negative bacilli. among pseudomonas aeruginosa strains highly resistant to carbenicillin (>/=3,200 mug/ml), half of them were susceptible to pc-904 at a concentration of 50 to 1,600 mug/ml. the minimal inhibitory concentration of pc-904 against p. aeruginosa strains resistant to carbenicillin (400 to 1,600 mug/ml) ranged from 3.1 to 25 mug/ml. ampicillin- and carbenicillin-resistant enterobacteriaceae s ... | 1978 | 248269 |
| cefuroxime, a beta-lactamase-resistant cephalosporin with a broad spectrum of gram-positive and -negative activity. | the in vitro activity of cefuroxime, a cephalosporin antibiotic, was investigated against 604 isolates and compared with the activity of other beta-lactam compounds. cefuroxime had activity comparable to that of other cephalosporins, including cefamandole and cefoxitin, against streptococcal and staphylococcal species; most streptococci were inhibited by 0.1 mug or less per ml, and staphylococci were inhibited by 1.6 mug or less per ml. enterococci were relatively resistant. cefuroxime inhibited ... | 1978 | 248268 |
| [in vitro antibacterial activity of tobramycin used in combination with cephalothin or carbenicillin (author's transl)]. | combinations of tobramycin (tob) with cephalothin (cet) or carbenicillin (cbpc) were evaluated by in vitro test against 161 clinical isolates of klebsiella pneumoniae, escherichia coli, indole-positive proteus, enterobacter and serratia marcescens which were not inhibited by 6.25 microgram/ml of cet. the combinations were considered to show synergy when there was a 4-fold or greater reduction in mic values (fic index less than or equal to 0.5) of both antibiotics when combined. synergy of tob wi ... | 1978 | 246946 |
| [in vitro reaction to antibiotics in klebsiella group organisms isolated from clinical cases (author's transl)]. | according to the antibiotic sensitivity tests of 228 klebsiella, they were found most sensitive resistant to ampicillin and penicillin. a great percentage of them had multiple resistance. | 1977 | 244771 |
| infectious complications of burns casualties during the yom-kippur war. | during the october 1973 military conflict, 41 burned patients hospitalized at the sheba medical center were closely followed up. all the patients who had burns occupying 20% or more of the body surface developed wound infections. pseudomonas aeruginosa was the major pathogen isolated. most infections occurred during the second week following the injury. serial cultures revealed that only the isolation of proteus species and p. aeruginosa from wounds could predict an infection caused by those mic ... | 1977 | 244453 |
| [diarrhea outbreak and bacterial resistance to ampicillin in newborns]. | twenty-eight healthy neonates from the san juan de dios hospital were studied to determine the pattern of antibiotic resistance of indigenous intestinal bacteria. sixty-eight per cent of infants had enterobacteriaceae resistant to several wide-spectrum antibiotics, including ampicillin; 28 per cent of the cultures had plasmid-mediated ampicillin resistance. in the course of the study, an outbreak of 10 acute cases of diarrhea occurred, not associated to any of the commonly known agents, includin ... | 1977 | 242927 |
| abnormal forms of bacteria produced by antibiotics. | subinhibitory concentrations of antibiotics can produce in vitro aberrant forms of bacteria that are similar to those observed in specimens and cultures from patients being treated with antibacterial agents. eight species of bacteria were grown on membranes placed on agar containing subinhibitory concentrations of nine antibiotics. the resulting organisms were examined by gram stain and electron microscopy. gram stains showed filamentous and granular forms of enterobacteria with bipolar staining ... | 1975 | 242211 |
| acute phlegmonous gastritis: differentiation from primary peritonitis and the peritonitis of collagen vascular disease. | 1975 | 241281 | |
| [synthetic medium for testing of susceptibility. ii. susceptibility of bacteria to sulphonamides (author's transl)]. | a comparative study of 9 media for testing the susceptibility of bacteria to 7 sulphonamides has been carried out. the evaluated culture-media included 4 "mueller hinton" media (mh), 4 others based on the formula of the "diagnostic sensitivity test" agar base (d.s.t.) and a "synthetic medium" (sm) which has been developed in our laboratory. mh and d.s.t. culture-media have been supplied by 4 manufacturing companies in europe and usa. a total number of 21 bacterial cultures have been employed. th ... | 1975 | 241178 |
| puncture wounds of the foot. | serious complications occurred in 29 of 887 children with puncture wounds of the feet treated over a four-year period at the dr. charles a. janeway child health centre. osteomyelitis in one of the small bones of the foot was the commonest complication and occurred when a cartilaginous surface (physeal plate or articular cartilage) had been violated. although systemic signs of osteomyelitis frequently are absent, this infectious process is refractory to medical management. the combined surgical a ... | 1975 | 241038 |
| [on sensitivity test of dibekacin by the disc method (author's transl)]. | 1975 | 240956 | |
| synthesis and antibacterial properties of methylsulfinyl and methylsulfonyl analongs of some nitrofurans. | the sulfoxides 5-methylsulfinyl-2-furaldehyde semicarbazone (2) and 1-[(5-methylsulfinyl-2-fufurylidene)amino]hydantoin (3) as well as the sulfones 1-[(5-methylsulfonyl-2-furfurylidene)animo]hydantoin (1) and 1-(5-methylsulfonly-2-furyl)-2-(6-amino-3-p-ridazyl)ethylene hydrochloride (4) have been prepared and tested for antibacterial activity against a number of gram-negative and gram-positive organisms. the compounds are much less active than the corresponding 5-nitrofuran derivatives, possibly ... | 1975 | 240940 |
| regulation of the ammonia assimilatory enzymes in salmonella typhimurium. | the regulation of glutamate dehydrogenase (ec 1.4.1.4), glutamine synthetase (ec 6.3.1.2), and glutamate synthase (ec 2.6.1.53) was examined for cultures of salmonella typhimurium grown with various nitrogen and amino acid sources. in contrast to the regulatory pattern observed in klebsiella aerogenes, the glutamate dehydrogenase levels of s. typhimurium do not decrease when glutamine synthetase is derepressed during growth with limiting ammonia. thus, it appears that the s. typhimurium glutamin ... | 1975 | 240804 |
| bacterial respiration-linked proton translocation and its relationship to respiratory-chain composition. | 1. the relationship between chain composition and the efficiency of respiration-linked proton translocation was studied in nine bacterial species of widely differing taxonomic and ecological status. 2. all the bacteria investigated contained respiratory chain dehydrogenases, ubiquinone and/or menaquinone, cytochrome b and cytochrome oxidase aa3 and/or o. in addition, some of these organisms also contained pyridine nucleotide transhydrogenase and/or cytochrome c. 3. leads to h+/o ratios of whole ... | 1975 | 240679 |
| [chemotherapy of purulent meningitis in children (author's transl)]. | purulent meningitis in patients admitted to the pediatric department of kyoto university hospital and affiliated institutions from 1951 through 1973 were studied with emphasis on the kinds of the causative organisms and the susceptibility of these organisms to antibiotics. the findings in this study have served to help select antibiotics most likely to be effective against this disease. the overall incidence of purulent meningitis was 0.68%. this figure decreased little throughout the period. as ... | 1975 | 240048 |
| [comparison of the antibacterial activity of amikacin (bb-k8) with other aminoglycosides against pathogens recently isolated from clinical materials (author's transl) ]. | we determined the antibacterial activity of amikacin against 1,277 strains of pathogenic bacteria isolated from clinical materials during 1974, including beta hemolytic streptococci, pneumococci, enterococci, staphylococcus aureus, staph. epidermidis, escherichia coli, klebsiella, enterobacter, citrobacter, serratia, proteus morganii and pseudomonas aeruginosa, and compared the minimum inhibitory concentration (mic) of this drug with gentamicin, dibekacin, tobramycin and kanamycin. 1)antibacteri ... | 1975 | 240047 |
| the effects of staphylococcus aureus and klebsiella pneumoniae peritonitis in mice exposed to normal and hypoxic conditions on red cell oxygen transport function. | normal mice exposed to 10% oxygen concentration developed a slight but statistically significant decrease in blood ph and a slight statistically insignificant decrease in red cell 2,3-dpg. mice that were infected intraperitoneally with staphylococcus aureus or klebsiella pneumoniae and exposed to 20% oxygen developed acidosis, hemoconcentration, and decreased red cell 2,3-dpg levels. when mice with acute bacterial peritonitis were exposed to 10% oxygen concentration they likewise developed signi ... | 1975 | 239991 |
| enterotoxigenic intestinal bacteria in tropical sprue. iii. preliminary characterization of klebsiella pneumoniae enterotoxin. | cell-free broth filtrates of a strain of klebsiella pneumoniae serotype 5 retained their capacity to induce fluid secretion in the rabbit ileal loop model after heating (100 c for 30 min), acid treatment (ph 4.4), and dialysis through viscose tubing. sequential passage of an acetone precipitate of the broth filtrate through diaflo membranes yielded an active fraction in the um 2, but not the um 10, retentate; this observation indicates that the molecular weight of the enterotoxin is in the range ... | 1975 | 239990 |
| comparative inhibitory activity of bl-s640 and two other cephalosporins. | in vitro antibacterial activity of bl-s640 was compared to that of cephalothin and cephalexin against gram-negative and gram-positive bacteria isolated from clinical specimens. bl-s640 demonstrated the best activity on nearly all microbial species studied, except for haemophilus influenzae and diplococcus pneumoniae against which cephalothin was slightly more active. | 1975 | 239917 |
| 1-alkyl-2-nitroimidazol-5-yl derivatives ii. n-substituted nitrones. | 1975 | 239726 | |
| [clinical effects of lividomycin on respiratory tract infections, primarily wet cases of bronchiectasis (author's transl)]. | patients with various respiratory infections, primarily wet cases of bronchiectasis, were treated with lividomycin (lvdm) at a dose of 1 g/day for about a week. the results obtained are as follows: 1. of the 15 patients with refractory bronchiectasis who had previously been treated with various other antibiotics, 11 patients (73.3%) responded to lvdm. although there was no patient who responded to lvdm excellently, good cures were achieved in 5 pateints and fair cures in 6 patients. 2. in bronc ... | 1975 | 239263 |
| [clinical evaluation of a new oral cephalosporin preparation, cephradine dry syrup, in pediatrics (author's transl)]. | 1975 | 239262 | |
| automated system for analytical microbiology v: calibration lines for antibiotics. | the accuracy of an automated system for the microbiological assay of antibiotics was increased by improvement attendant to connection to an on-line computer. the system was used to investigate the suitability of four forms of interpolation formulas by assaying for chlortetracycline and erythromycin. the calibration lines were prepared as point-to-point straight-line approximations and as cubic equations. cubic equations through four calibration points were preferred. since the automated system w ... | 1975 | 239199 |
| purification and properties of citrate lyase from streptococcus diacetilactis. | citrate lyase from streptococcus diacetilactis has been purified to yield a protein that was homogeneous as judged by sedimentation velocity and sedimentation equilibrium experiments. the enzyme's sedimentation coefficient is 16.8 s and its molecular weight is around 585,000. it contains three nonidentical subunits of about 53,000, 34,000, and 10,000 daltons. the enzyme in its active form contains an acetyl group which turns over during the citrate cleavage reaction. removal of the acetyl group ... | 1975 | 238987 |
| regulation of nitrogen metabolism in escherichia coli and klebsiella aerogenes: studies with the continuous-culture technique. | ammonia-nitrogen-limited continuous cultures of escherichia coli and klebsiella aerogenes contain induced levels of glutamine synthetase that is deadenylyated (i.e., fully active). in the presence of excess ammonia or glutamate in glucose-limited cultures of e. coli, glutamine synthetase is repressed and adenylylated (inactive). the average state of adenylylation (n) is a linear function of the specific growth rate. at low specific growth rates, glutamine synthetase is adenylylated; as the speci ... | 1975 | 238954 |
| gene order of the histidine utilization (hut) operons in klebsiella aerogenes. | p1-sensitive mutants of klebsiella aerogenes were isolated and the gene order of the hut region was then determined using p1-mediated transduction. the genes are located in the klebsiella chromosome between gal and bio as in salmonella typhimurium. the gene order, gal, huti, hutg, hutc, huu, huth, bio is also the same as that observed in s. typhimurium. | 1975 | 238937 |
| a new parenteral cephalosporin. sk&f 59962: in vitro and in vivo antibacterial activity and serum levels in experimental animals. | sk&f 59962, a new parenteral cephalosporin was found to have a high order of in vitro and in vivo antibacterial activity against a broad-spectrum of clinical isolates. when tested in vitro against gram-negative organisms, sk&f 59962 was consistently more active than cefazolin and far superior to cephalothin. this new antibiotic had activity equal to that of cephalothin against gram-positive bacteria. enterobacter species were found to be susceptible to sk&f 59962. in mouse infection studies usin ... | 1975 | 238925 |
| studies on stimulation and properties of antiglobulin antibodies. ii. antiglobulin antibodies against homologous globulins and antigens of thermally denatured autologous sera in the sera of rabbits immunized with various antigens. | sera of 48 rabbits after long-term immunization with suspensions of diplococcus pneumoniae, klebsiella friedländeri, proteus ox19 and solution of bovine albumin were examined for antibodies reacting with homologous gamma-globulins and antigens of thermally denatured autologous sera. appearance of antibodies of this type was related to duration of immunization, but not related to the type of antigen used. the experimental results were explained as a result of altered antigenic properties of antib ... | 1975 | 238486 |
| metabolism of deoxycorticosterone by human fecal flora. | 21-dehydroxylation, a feature of metabolism of corticoids in humans, was observed in mixed cultures of fecal flora of normal individuals on a western diet. the model substrate, 11-deoxycorticosterone (doc), was metabolized to 3alpha-21-dihydroxy-5beta-pregnan-20-one (thdoc), 3alpha-hydroxy-5beta-pregnan20-one (pregnanolone), and to two unidentified structures, metabolites x and y. doc was not metabolized in all media supporting growth of fecal flora. conversion required an initial ph between 6.0 ... | 1975 | 238472 |
| molecular biology of nitrogen fixation. | 1975 | 238283 | |
| aminoglycosides from the clinical microbiologist's viewpoint. | the author is discussing the aminoglycosides from the clinical microbiologists viewpoint. it is both an review of the literature and a personal attempt to put into perspective some of his own experience with these agents and reports in the literature. he is discussing the influence of the culture media composition of the outcome of susceptibility tests with these agents as well as the problems of bacterial resistance. furthermore the topic of rapid and reasonably accurate serum drug level determ ... | 1975 | 237839 |
| letter: group-y meningococcal disease. | 1975 | 237449 | |
| cephalothin and cephaloridine therapy for bacterial meningitis. | the efficacy of cephalothin and cephaloridine in the treatment of bacterial meningitis was evaluated from a review of 106 cases reported in the literature. fifty-nine percent of 34 patients treated with intravenous cephalothin responded suboptimally; those receiving daily doses of 12 g or more fared significantly better (p less than 0.025). in contrast, 74% of 72 patients treated with cephaloridine responded favorably; those who received concomitant intrathecal cephaloridine responded significan ... | 1975 | 237448 |
| bacteriophage-borne enzymes in carbohydrate chemistry. part i. on the glycanase activity associated with particles of klebsiella bacteriophage no. 11. | the preparation and use of particles of klebsiella bacteriophage no. 11 are described. a glycanase activity associated with the viruses catalyses the depolymerization of (alkali-treated) klebsiella serotype 11 capsular polysaccharide, ultimately to a mixture of oligosaccharides consisting of one or two repeating units. mainly glucosidic bonds are hydrolysed. the substrate specificity of the viral enzyme has been characterized by using derivatives of serotype-11 polysaccharide, as well as 81 hete ... | 1975 | 236830 |
| the structure of klebsiella serotype ii capsular polysaccharide. | using periodate oxidation, methylation analysis, the characterization of oligosaccharides obtained by partial acid hydrolysis, p.m.r. spectroscopy, and analytical ultracentrifugation, the structure of the (mildly alkali-treated) klebsiella serotype 11 capusular polysaccharide has been elucidated. the tetrasaccharide repeating-unit comprises the sequence yields 3)-beta-d-glcp-(1 yields 3)-beta-d-glcuap-(1 yields 3)-alpha-d-galp-(1 yields with a 4,6-o-(1-carboxyethylidene)-alpha-d-galactosyl resid ... | 1975 | 236829 |
| long-term therapy of chronic bacterial prostatitis with trimethoprim-sulfamethoxazole. | trimethoprim (tmp) meets all of the theoretical requirements of diffusion into, and actual concentration in, human prostatic fluid. when tmp is combined with the sulfonamide sulfamethoxazole (smx), potentiation of antibacterial activity is achieved and the development of resistant bacterial strains is less likely to occur. in our initial use of tmp-smx in the treatment of 13 men with chronic bacterial prostatitis due to gram-negative organisms, patients were given two tablets of tmp-smx twice da ... | 1975 | 236820 |
| evaluation of bacterial contamination in blood processing. | in the routine deglycerolization of frozen red blood cells, a bottle of solution intended as a final wash (0.8% nacl, 0.2% dextrose) was found to be abnormally colored and slightly turbid. close inspection revealed a small crack in the base of the bottle. a pure growth of klebsiella pneumoniae was cultured. the rabbit pyrogen test on the solution was positive using 2.5 mul as was the limulus amebocyte lysate (lal) test at a dilution of 1:10-5 for endotoxin. studies of the growth of this organism ... | 1975 | 236609 |
| impedance monitoring of bacterial activity. | bacterial activity and growth were monitored by following the changes of electrical impedance of cultures in liquid media. the signal is expressed automatically as a curve similar to grwoth curves produced by other methods. the technique offers a new, rapid and sensitive means of detecting active micro-organisms and is potentially the basis of rapid automated systems in this field. the impedance changes indicate that the micro-organisms metabolise substrates of low conductivity into products of ... | 1975 | 236390 |
| nationwide epidemic of septicemia caused by contaminated infusion products. iv. growth of microbial pathogens in fluids for intravenous infusions. | septicemia caused by contaminated infusion fluid is a newly appreciated hazard of intravenous infusion therapy. microorganisms of the tribe klebsielleae (klebsiella, enterobacter, and serratia) have predominated in these infections. members of this tribe found to possess a selecive ability over common non-klebsielleae microbial pathogens to proliferate rapidly in commerical parential fluids contaning clucose at room temperautre. fifty-one klebsielleae strains, washed twice before inoculation of ... | 1975 | 236343 |
| effect of aeration and sodium on the metabolism of citrate by klebsiella aerogenes. | anaerobic growth of klebsiella aerogenes ncdo 711 (nctc 418) on citrate was dependent on the presence of na+ in the medium, and fermentation of citrate was mediated via the fermentation pathway enzymes, citrate lyase and a na+-dependent oxalacetate decarboxylase. this confirms the previous findings on strain nctc 418. growth under aerobic conditions was independent of na+. the mean generation time for cells grown aerobically on either na+ or k+ citrate medium was about 60 min, with a molar growt ... | 1975 | 236280 |
| the classic bacterial pneumonias. | 1975 | 236155 | |
| a three year retrospective analysis of septic shock in a general hospital. | records of all patients with a clinical diagnosis of septic shock were reviewed retrospectively; cases occurred from august 1968-july 1971 in a general teaching hospital with 667 beds. in the 3-year period, 80 patients (38 males and 42 females) presented with 82 episodes of septic shock; this represented 14% of total hospital admissions to intensive care. the age range was from 15-78 years, with a mean of 52+ or -16 years. the incidence of the syndrome increased with age, reaching a maximum i ... | 1975 | 235790 |
| 1-alkyl-2-nitroimidazol-5-yl derivatives. i. | 1975 | 235267 | |
| genetic control of glutamine synthetase in klebiella aerogenes. | mutations at two sites, glna and glnb, of the klebsiella aerogenes chromosome result in the loss of glutamine synthetase. the locations of these sites on the chromosome were established by complementation by episomes of escherichia coli and by determination of their linkage to other genetic sites by transduction with phage p1. the glnb gene is located at a position corresponding to 48 min on the taylor map of the e. coli chromosome; it is linked to trya, nadb, and gua. the glna gene is at a posi ... | 1975 | 234939 |
| identification of the structural gene for glutamine synthetase in klebsiella aerogenes. | mutations at two sites of the klebsiella aerogenes chromosome, unlinked by transduction with phages pw52 and p1, result in the lack of enzymatically active glutamine synthetase. a mutation in the glnb site leads to a marked decrease in the formation of an apparently normal enzyme. some of the mutations in the glna site lead to the production of enzymatically inactive material capable of reacting with anti-glutamine synthetase serum. the revertant of a glna mutant was found to produce a glutamine ... | 1975 | 234938 |
| purification, structure and properties of the respiratory nitrate reductase of klebsiella aerogenes. | 1. the respiratory nitrate reductase of klebsiella aerogenes was solubilized from the bacterial membranes by deoxycholate and purified further by means of gel chromatography in the presence of deoxycholate, and anion-exchange chromatography. 2. dependent on the isolation procedure two different homogeneous forms of the enzyme, having different subunit compositions, can be obtained. these forms are designated nitrate reductase i and nitrate reductase ii. both enzyme preparations are isolated as t ... | 1975 | 234757 |
| [clinico-bacteriological correlations in patents with chronic nonspecific diseases of the lungs]. | 1975 | 234629 | |
| in vitro activity of sisomicin, an aminoglycoside antibiotic, against clinical isolates. | sisomicin, a new aminoglycoside antibiotic which is produced by micromonospora myoensis, was studied against 565 clinical isolates of gram-negative bacilli and gram-positive cocci. with the exception of serratia marcescens, over 90% of isolates of gram-negative bacilli were inhibited by 1.56 mug/ml or less of sisomicin. sisomicin was slightly more active than gentamicin and tobramycin aganist isolates of escherichia coli, proteus mirabilis and klebsiella spp. it was substantially more active tha ... | 1975 | 234415 |
| changes in protein synthesis on mitomycin c induction of wild-type and mutant clodf13 plasmids. | mitomycin c treatment of escherichia coli k-12 cells containing the nonconjugative plasmid clodf13 resulted in inhibition of host chromosome protein synthesis and a high rate of synthesis of two clodf13-specified proteins whose molecular weights correspond to cloacin and immunity protein. five molecules of immunity protein were synthesized for each cloacin df13 molecule. mitomycin c-treated cells containing a copy mutant of clodf13 made three to four times as much of each protein as cells contai ... | 1977 | 233723 |
| prolonged cultures of entamoeba histolytica. | 1979 | 232687 | |
| cloning of the entire region for nitrogen fixation from klebsiella pneumoniae on a multicopy plasmid vehicle in escherichia coli. | 1979 | 232231 | |
| specificity of attachment of certain enterobacteriaceae to mammalian cells. | the specificity of adherence of various enterobacteriaceae to different mammalian cells was studied in vitro. 3h-labelled organisms of the same species isolated from various clinical sources differed significantly in their abilities to adhere to the same mammalian cells. bacteria frequently adhered better to cells derived from sites other than those analogous to their original source. bacteria did not display consistently 'high' or 'low' attachment to a variety of human and tissue-cultured cells ... | 1979 | 231084 |
| investigations into the klebsiella aerogenes pentitol operons using specialised transducing phages lambdaprbt and lambdaprbt dal. | 1979 | 230352 | |
| lethal effect of complement and lysozyme on polymyxin-treated, serum-resistant gram-negative bacilli. | when genetically serum-resistant escherichia coli, klebsiella pneumoniae, and citrobacter freundii, but not pseudomonas aeruginosa or proteus mirabilis, were exposed to polymyxin b, they became susceptible to the bactericidal action of normal human and rabbit sera. in constrast, beta-lactam and aminoglycoside antibiotics did not render any serum-resistant bacteria serum-sensitive. synergy between polymyxin b and the serum bactericidal system could be demonstrated by the addition of polymyxin b t ... | 1979 | 229175 |
| mecillinam-ampicillin synergism in experimental enterobacteriaceae meningitis. | the in vitro activities of mecillinam, a new beta-amidinopenicillin, and ampicillin, alone and in combination, against an escherichia coli strain and a klebsiella pneumoniae strain were compared, and these results were correlated with their respective activities in vivo in experimental meningitis. the mecillinam-ampicillin combination was synergistic in vitro against both strains when tested by a modified checkerboard technique (bacteriostatic synergy). however when quantitative bactericidal syn ... | 1979 | 228591 |
| in vitro combination of mecillinam with cephradine or amoxycillin for organisms resistant to single agents. | of 36 multi-resistant gram-negative bacilli isolated from different cases of urinary tract infection, 18 strains of escherichia coli, klebsiella, enterobacter, proteus, providencia and serratia with the exception of acinetobacter species showed synergy when mecillinam was combined with cephradine or amoxycillin in the ratio of 1:1. combination with cephradine was synergistic on sixteen occasions and amoxycillin on six. synergy, which might have clinical relevance, was demonstrated only when the ... | 1979 | 227829 |
| [effects of ampicillin and cefazolin combined with mecillinam (author's transl)]. | combination effects of mecillinam + ampicillin and mecillinam + cefazolin were investigated by the cross diffusion test and by the kinetics of bactericidal action. synergism was found by cross diffusion in about 50% of strains of e. coli, klebsiella and proteus. sensitivity against ampicillin was correlated with synergism. in mecillinam-resistant strains, synergism is usually absent. the combination of ampicillin or cefazolin with mecillinam leads to bactericidal acceleration; the effects are co ... | 1978 | 226099 |
| "triple infections" (fungal, bacterial and viral) in immunosuppressed renal transplant recipients. | in a period of 5 years, 8 out of 77 renal transplant patients showed simultaneous fungal, bacterial and viral infections. candida albicans was found in all cases. the most severe bacterial complications were infections with klebsiella, pseudomonas and staphylococcus aureus. cytomegalovirus, persistent hbsag positive hepatitis, herpes zoster, and herpes simplex infections were also found. seven patients died of bacterial superinfection and miliary tuberculosis. the data presented show that "tripl ... | 1979 | 224003 |
| clostridia as pathogens in neonatal necrotizing enterocolitis. | 1979 | 221640 | |
| role of peripheral side chains of vitamin b12 coenzymes in the reaction catalyzed by dioldehydrase. | 1979 | 217415 | |
| stopcock: bacterial contamination in invasive monitoring systems. | 1979 | 215570 | |
| nitrogenase x: mössbauer and epr studies on reversibly oxidized mofe protein from azotobacter vinelandii op. nature of the iron centers. | under anaerobic conditions the molybdenum-iron protein (mofe protein) from azotobacter vinelandii can be reversibly oxidized with thionine. electron paramagnetic resonance studies reveal that the oxidation proceeds in two distinct phases: the mofe protein can be oxidized by four electrons without loss of the epr signal from the s = 3/2 cofactor centers. a second oxidation step, involving two electrons, leads to the disappearance of the cofactor epr signal. in order to correlate the events during ... | 1978 | 215215 |
| experimental evolution in bacteria. | 1978 | 212253 | |
| electron-paramagnetic-resonance studies on nitrogenase of klebsiella pneumoniae. evidence for acetylene- and ethylene-nitrogenase transient complexes. | klebsiella pneumoniae nitrogenase exhibited four new electron-paramagnetic-resonance signals during turnover at 10 degrees c, ph7.4, which were assigned to intermediates present in low concentrations in the steady state. 57fe-substituted mo--fe protein showed that they arose from fe--s clusters in the mo--fe protein of nitrogenase. the new signals are designated: ic, g values at 4.67, 3.37 and approx. 2.0; vi, g values at 2.125, 2.000 and 2.000; vii, g values at 5.7 and 5.4; viii, g values at 2. ... | 1978 | 210766 |
| coenzyme b12-dependent diol dehydratase: regulation of apoenzyme synthesis in klebsiella pneumoniae (aerobacter aerogenes) atcc 8724. | immunochemical studies demonstrated that klebsiella pneumoniae (aerobacter aerogenes) atcc 8724 produces only a single diol dehydratase whether grown on glycerol or on 1,2-propanediol. the enzyme was subject to induction by 1,2-diols and to catabolite repression reversed by cyclic amp. | 1978 | 210157 |
| electron paramagnetic resonance studies on membrane-bound respiratory nitrate reductase of klebsiella aerogenes. | 1978 | 207577 | |
| subcellular distribution of enzymes involved in alpha-glucan utilization in klebsiella pneumoniae. proteins of cytopasm, periplasm, cytoplasmic and outer membrane. | 1978 | 206221 | |
| spontaneous infectious diseases of marmosets. | the various species of marmosets are susceptible to a wide variety of infectious agents of which only a few have been fully characterized. little is known concerning spontaneous disease in their natural habitat, and often deaths in the laboratory go unexplained. in captivity, herpesvirus-t infection appears to be the most important viral infection, but serious disease may also follow infection with measles virus (rubeola) and an unidentified paramyxovirus. bacterial diseases are multiple, but ra ... | 1978 | 205855 |
| anaerobes in human biliary tracts. | during a 2-year period, 1,892 patients underwent biliary tract surgery at the mayo clinic. both aerobic and anaerobic cultures of bile were performed in 371 of these patients. sixty-nine percent of the cultures were positive, and 41% (117) of these grew anaerobes, although they were present in pure culture only twice. mixed cultures most commonly contained four different organisms (three aerobes and one anaerobe). bacteroides fragilis was the single most commonly isolated anaerobe and ranked fou ... | 1977 | 200634 |
| [specific endonuclease of klebsiella pneumoniae oks]. | 1977 | 199404 | |
| on the structure of the prosthetic group of citrate (pro-3s)-lyase. | the prosthetic group of citrate (pro-3s)-lyase from klebsiella aerogenes as well as streptococcus diacetilactis was obtained eigher by beta elimination or pronase digestion of the enzyme and purified by deae-cellulose chromatography. the compound was shown to contain 3 mol of po4, 2 mol of ribose, and 1 mol of sulfhydryl/mol of adenine. 5'-amp and dephospho-coa are components of the prosthetic group. the evidence obtained so far support our proposed structure of 3' (or 2') leads to 1''-(5''-phos ... | 1977 | 197081 |
| bacteriology of the human biliary tract and the duodenum. | using the modern anaerobic transport media and meticulous culture techniques, 74 patients undergoing biliary tract surgery were studied. the biliary system was found to be sterile in 58 patients (78%). fifteen patients had 35 isolates of aerobic and facultative bacteria. the most common ones were klebsiella, enterococcus, and escherichia coli. the only anaerobe isolated was clostridium perfringens. eight of 17 patients (47%) with acute cholecystitis and five of 49 patients (10%) with chronic cho ... | 1977 | 195558 |
| [studies on the antimicrobial effect of vitamin d (author's transl)]. | in in vitro studies vitamin d3 proved inhibitory on strains of staphylococcus aureus, streptococcus pyogenes, klebsiella pneumoniae. escherichia coli, and candida albicans. in the presence of 5x10(4)-9x10(4) iu/ml vitamin d3 the organisms were killed or reacted with a marked growth inhibition. | 1977 | 195120 |
| structural investigation of klebsiella serotype k36 polysaccharide. | klebsiella d36 capsular polysaccharide has been investigated by methylation, smith-periodate oxidation and partial hydrolysis techniques. the structure was found to consist of a hexasaccharide repeating unit as shown. the anomeric configurations of the sugar residues were determined by 1h and 13cn.m.r.spectroscopy on isolated oligomers obtained during the degradative studies and on the intact polysaccharide. | 1977 | 193645 |
| [etiology of acute respiratory infection in hospitalized children (author's transl)]. | incidence of respiratory tract infection represents 23% of the total number of admissions between 1-24 months of age, during a period of 18 months. the diagnosis were: bronchiolities, 143 cases; bronchopneumonia, 134 cases; tracheobronchitis, 50 cases; laryngitis, four cases, and bacterial pneumonia, 61 cases. monthly incidence was maximal in december of each year. from the total group, 144 cases were included in the present study to determine etiology of the infection. in 19% of the cases a ser ... | 1976 | 193420 |
| synthesis and some biological properties of 6-aminopenicillanic derivatives. | the properties of 33 6-aminopenicillanic derivates were described, the majority of which and particularly all 3,4-disubstituted phenyl derivatives, are new compounds. these derivatives were synthesized by three different methods consisting in treating of 6-aminopenicillanic acid (6-apa) with appropriate phenylthio -- and phenoxyalkanecarboxylic acids. the method consisting in use of aryloxyketenes is new and claimed by the patent applications. all synthesized compounds were screened for their bi ... | 1977 | 193092 |
| [bacteriological studies on mecillinam (author's transl)]. | 1977 | 192923 | |
| expression of klebsiella nif and his genes in salmonella typhimurium. | derivatives of salmonella typhimurium carrying f prime or p prime plasmids with klebsiella nif and his genes had specific nitrogenase activities similar to klebsiella in selective conditions, even to showing "hyperinduction" under argon. no evidence was obtained for catabolite repression of normal nif expression but dibutyl cyclic amp often augmented "hyperinduction". in non-selective conditions the klebsiella his nif determinants were rapidly lost from the plasmids; the low levels of nif expres ... | 1977 | 192833 |
| anaerobic bacteria in biliary disease in elderly patients. | gallbladder bile from 52 elderly subjects who had undergone biliary tract surgery was examined for the presence of bacteria. twelve patients had sterile bile, 18 specimens of bile yielded anaerobes as well as aerobes, and 22 yielded aerobic bacteria only. escherichia coli was the most commonly isolated organism (30 strains). bacteroides fragilis was the most frequently encountered anaerobic bacterium and was found in 15 patients. the klebsiella-enterobacter group was the second most commonly iso ... | 1977 | 192815 |