Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| effects of nonthyroidal illness on thyroid function. | despite the absence of thyroid disease, patients with nonthyroidal illness frequently have changes in serum thyroid hormone measurements that may suggest either hypothyroidism or hyperthyroidism. serum t3 levels are frequently decreased mainly because of a decrease in the rate of t3 production from t4. the free t3 concentration may be either normal or reduced as well. the binding of t4 and t3 by the serum-binding proteins is almost always impaired, resulting in an increase in the dialyzable frac ... | 1985 | 3932793 |
| purification, characterization and immunological properties of the capsular polysaccharide of pasteurella haemolytica serotype t15: its identity with the k62 (k2ab) capsular polysaccharide of escherichia coli and the capsular polysaccharide of neisseria meningitidis serogroup h. | capsular polysaccharide from two strains of pasteurella haemolytica serotype t15 was purified and characterized by chemical analysis and nmr spectroscopy. the polymer, a teichoic acid, proved to be very similar in structure to the capsular polysaccharide of p. haemolytica serotype t4 and identical to the previously described k62 (k2ab) capsular polysaccharide of escherichia coli, and the capsular polysaccharide of neisseria meningitidis serotype h, i.e. ----(2-glycerol-3)----(phosphate)----(4-al ... | 1985 | 3932592 |
| increased thyroid-stimulating hormone response to thyrotropin-releasing hormone in hyperprolactinemic women. | the tsh response to trh and basal thyroid function were studied in 21 unselected women with hyperprolactinemia. the mean serum free t4 (ft4) concentration was significantly lower in hyperprolactinemic women than in normal women. the mean basal tsh concentrations were similar, but the incremental tsh response to trh was significantly greater in hyperprolactinemic women than in normal women. increased dopaminergic inhibition of tsh release has been reported in hyperprolactinemic women. the low ser ... | 1985 | 3932450 |
| measurement of thyroxine uptake from serum by cultured human hepatocytes as an index of thyroid status: reduced thyroxine uptake from serum of patients with nonthyroidal illness. | the uptake of t4 from human serum by cultured human hepatoma cells, hep g2, was compared with the free t4 estimates by equilibrium dialysis (dt4) and a resin uptake method (ft4i). the cellular uptake of t4 (ct4) was highly correlated with dt4 values (r = 0.97; p less than 0.0005) and ft4i values (r = 0.99; p less than 0.0005) in sera from euthyroid subjects and hypothyroid and thyrotoxic patients. in patients with abnormal levels of serum t4-binding globulin, the fractional uptake of t4 decrease ... | 1985 | 3932446 |
| bacteriophage t4, a new vector for the expression of cloned genes. | the amino-terminal portion of the t4 riib gene has been fused to the coding sequence of a truncated lacz gene from escherichia coli, giving rise to a fusion protein with beta-galactosidase activity. the 3192-bp riib-lacz gene fusion was transferred into phage t4, and enzymatically active protein was produced after phage infection. t4 may be a useful expression vector in special circumstances, in particular for proteins whose accumulation in e. coli is limited by sensitivity to proteases. | 1985 | 3932131 |
| in vivo release of prolactin in rana ridibunda following an intravenous injection of thyrotropin-releasing hormone. | all experiments were performed on female rana ridibunda during the months of april and may. injections were made into the canulated vena abdominalis and blood samples were taken up to 8 hr thereafter and checked for prolactin concentration using a heterologous frog radioimmunoassay. an injection of 10 micrograms trh (thyrotropin releasing hormone; pglu-his-pro nh2) will elevate control serum levels of 28.54 +/- 5.40 ng/ml prolactin to 59.56 +/- 8.78 ng/ml (n = 6) and this within half an hour. a ... | 1985 | 3932125 |
| serum thyroid stimulating hormone (tsh), total thyroxine (tt4), total triiodothyronine (tt3), triiodothyronine uptake ratio (t3ur), free thyroxine index (ft4i), free triiodothyronine index (ft3i) and t3/t4 ratio in the elderly. | 1985 | 3932018 | |
| involvement of calcium in the transient depolarization of e.coli cytoplasmic membrane induced by phage adsorption: a study with the fluorescent calcium indicator quin2. | adsorption of phage t4 to its outer membrane receptor (the lipopolysaccharide) triggers a transient depolarization of the cytoplasmic membrane which is prevented upon addition of egta, suggesting that calcium is necessary for the transmission of the signal between the two membranes. using the fluorescent indicator quin2, we show that t4 adsorption triggers the release of envelope-bound calcium, the amount of which increases with the number of infecting phages. since this amount was the same whet ... | 1985 | 3931640 |
| hormonal response to thyrotropin-releasing hormone in healthy horses and in horses with pituitary adenoma. | cortisol, triiodothyronine (t3), thyroxine (t4), insulin, and glucose responses to thyrotropin-releasing hormone (trh) were evaluated in 12 healthy, mature horses and in 7 horses and 4 ponies with clinical signs of pituitary adenoma (pa). within 1 hour after trh administration, the increase in t3 and t4 was similar in healthy horses and animals with pa. plasma cortisol in the group with pa increased (p less than 0.05) within 0.25 hours after trh administration, and remained increased for 1.5 hou ... | 1985 | 3931519 |
| elevated basal levels and exaggerated responses to thyrotrophin-releasing hormone of prolactin and thyrotrophin in turner-noonan-syndrome. | basal levels of prolactin (prl), fsh, lh, testosterone, estradiol, total thyroxine (t4), total triiodothyronine (t3) and thyrotrophin (tsh) were determined in four males with turner-noonan-syndrome. the responsiveness of gonadotrophins to lh-rh (100 micrograms i.v.) and of prl and tsh (200 micrograms i.v.) was studied. high basal levels and exaggerated responses to trh of prl were found in all patients. however no evidence of any of the well known causes of hyperprolactinaemia could be detected ... | 1985 | 3931504 |
| phenotypic expression of t lymphocytes in thymus and peripheral lymphoid tissues. | the pattern of expression of cell surface antigens and their relationship to the sequence of t-cell differentiation were delineated by the application of a series of monoclonal antibodies against t cells on tissue sections. the morphologic features and location of t-cell differentiation can be categorized into four stages: 1) subcapsular thymocytes, 2) cortical thymocytes, 3) medullary thymocytes, and 4) peripheral t cells. phenotypically, on the basis of reactivity with monoclonal antibodies, t ... | 1985 | 3931482 |
| persistence and progression of immunologic abnormalities in haemophilia. | immunologic parameters in 51 patients with haemophilia treated with cryoprecipitate from volunteer donors or with commercial lyophilized concentrate were studied on 2-7 occasions. concentrate users had significantly decreased mean t4 (helper)/t8 (suppressor) lymphocyte ratios when the initial (1.5 +/- .43) and most recent (1.25 +/- .60) values were compared (p less than .001), whereas in cryoprecipitate users mean values remained normal. of the 22 concentrate users with initially normal t4/t8 ra ... | 1985 | 3931282 |
| [dependence of the degree of antibacterial and antiphage action of ozone on cell and phage particle concentrations in nutrient media]. | the work was aimed at studying the inactivating effect of ozone on escherichia coli k-12 ab1157, pseudomonas aeruginosa pa01, erwinia herbicola eh103 and their phages t4, sm and i4. the degree of bacterial and phage inactivation was found to increase with a decrease in their initial concentration during the treatment. the effect depends on differences in the quantity of ozone per cell or per phage particle in the reaction medium. this conclusion is based on the fact that, irrespective of the sus ... | 1985 | 3930926 |
| [thyroid hormones in women with liver cirrhosis]. | basal thyroid hormone levels were measured in 68 women with liver cirrhosis (lc) of different etiology (alcoholic n = 34, posthepatitic b n = 9, pbc n = 5, cryptogenetic n = 18, m. wilson n = 2). in addition the rise of tsh after 400 micrograms trh was measured in 23 women with lc and compared with the data obtained from 17 women of a control group. there was no difference of the median t4-concentrations (lc 8.0 micrograms/dl versus 7.2 micrograms/dl) but a significant correlation of t4 to the g ... | 1985 | 3930834 |
| lymphocyte anergy specific to toxoplasma gondii antigens in a baby with congenital toxoplasmosis. | a baby's clinical course during her first year of life documented her congenital infection with toxoplasma gondii. certain of her peripheral blood lymphocyte subtype numbers and functions were studied at intervals during this year: this patient's lymphocytes did not respond to toxoplasma gondii antigens when she was 2 or 6 months old but did respond when she was 1 year old. her lymphocyte anergy appeared to be a specific impairment or delay in lymphocyte blastogenic response to t. gondii antigen ... | 1985 | 3930751 |
| progesterone has no effect on serum thyroxine-binding globulin concentration in men. | to examine the possible effect of progesterone on circulating t4-binding globulin (tbg) in men, ria measurements of plasma tbg and t4 levels were made before and after weekly administration of 500 mg medroxyprogesterone acetate, im, to men being treated for paraphilia (sexual deviation syndromes). no change in the mean pretreatment plasma tbg concentration was found after 7-29 days [21.5 +/- 1.2 (+/- sem) to 22.0 +/- 0.9 microgram/ml; n = 14) or 381-415 days (23.0 +/- 2.5 to 23.1 +/- 2.5 microgr ... | 1985 | 3930557 |
| hyperfractionation in the radiation therapy of unresectable non-oat cell carcinoma of the lung: preliminary report of a rtog pilot study. | patients with localized unresectable non-oat cell carcinoma of the lung were treated by supervoltage radiation therapy to the primary tumor, mediastinum and supraclavicular lymph nodes with 50.4 gy, 42 fractions of 1.2 gy, twice daily, 4 to 6 hours apart, 5 times a week. small field treatment to the known involved areas of primary and lymph nodes was given from 9.6 to 24 gy, also with 1.2 gy, twice daily. one hundred twenty-five patients were entered, three of whom were cancelled and two were in ... | 1985 | 3930443 |
| free and total triiodothyronine and thyroxine in malnourished jamaican infants. the effect of diet on plasma levels of thyroid hormones, insulin and glucose during recovery. | plasma concentrations of free triiodothyronine (ft3), total triiodothyronine (tt3) and total thyroxine (tt4) were reduced to 63.0, 37.7, 61.7 per cent of controls respectively in protein-energy malnutrition (pem), while free thyroxine (ft4) was elevated by 23 per cent. there was a gradual increase of both tt4 and tt3 during recovery. the ratio of free to bound hormones was high in malnutrition and declined with recovery, indicating a deficiency of thyroid-hormone binding in malnutrition. the obs ... | 1985 | 3930436 |
| free triiodothyronine (t3) and thyroxine (t4) in a group of unipolar depressed patients and normal subjects. | we examined levels of free triiodothyronine (ft3) and free thyroxine (ft4) in serum from a group of 32 patients with unipolar major depression and 46 normal control subjects using the amerlex (amersham, arlington heights, il) ria procedures for these hormones. free t3 levels were significantly lower (p less than 0.004) in the depressed patients as a group (5.02 +/- 1.01 pmol/l, mean +/- sd) than in the normal control subjects (5.74 +/- 1.23 pmol/l). free t3 levels were lower (p less than 0.01) i ... | 1985 | 3929846 |
| post-natal thyroid function in low birth weight infants; a longitudinal assessment of free thyroxine and thyroid hormone binding globulin. | because the concentrations of serum free thyroxine (ft4) and thyroid hormone binding globulin (tbg) have not been fully evaluated in preterm infants at the immediate post-natal period, we studied the longitudinal changes of serum ft4 and tbg, along with thyroxine (t4) and thyroid stimulating hormone (tsh), at birth (cord blood), 2 days, 1 week and 2 weeks of age in 7 infants with birth body weight less than or equal to 1000 g, 7 infants with body weight 1001 to 1350 g, 11 infants with body weigh ... | 1985 | 3929519 |
| changes in thyroidal function and liver udpglucuronosyltransferase activity in rats following administration of a novel imidazole (sc-37211). | sc-37211, an imidazole with antianaerobic activity, was administered po to male rats for 2 weeks at dosages of 20, 60, and 200 mg/kg/day. histological changes in the thyroid included irregularly shaped follicles and slightly enlarged follicular cells. serum triiodothyronine (t3) and/or thyroxine (t4) were significantly decreased in treated animals at all dosages; these decreases were not observed following a 2-week recovery period. the half-life of serum [125i]thyroxine was also significantly de ... | 1985 | 3929431 |
| interleukin 2 promotes growth and cytolytic activity in human t3+4-8- thymocytes. | human thymocytes bearing t3 but neither t4 nor t8 antigens (t3+4-8- cells) were obtained after negative selection of thymocytes, either fresh or cultured in medium containing recombinant interleukin 2 (il-2), by treatment with na1/34, okt4a and b9.4 monoclonal antibodies (which recognize t6, t4, and t8 antigens, respectively) and complement. quantitative flow cytometry showed a 98% pure population of t3+4-8- lymphocytes, which included proliferating cells. the growth and maturation requirements ... | 1985 | 3929254 |
| normal thyrotrophin response to intravenous thyrotrophin releasing hormone administration: the best index of optimal l-thyroxine therapy in primary hypothyroidism. | normalization of basal thyrotrophin (tsh) level is used as the endpoint in l-thyroxine (l-t4) therapy of primary hypothyroidism. however, several reports have questioned the reliability of this index because of seasonal variation of tsh. therefore, we studied 85 consecutive patients with primary hypothyroidism over a period of 3.5 y. in these patients, tsh response (delta tsh) to intravenous thyrotrophin releasing hormone (trh) administration was examined when basal tsh was normalized with l-t4 ... | 1985 | 3929241 |
| variant thyroxine-binding globulin in serum of australian aborigines: its physical, chemical and biological properties. | low serum total thyroxine (tt4) and triiodothyronine (tt3) is found in approximately 40% of australian aborigines. studies were carried out to characterize the properties of thyroxine-binding globulin (tbg) in these australian aborigines to explain the observed reduction of thyroid hormone concentration in their serum. tbg from aborigines with low serum tt4 concentrations was compared to tbg from aborigines with normal tt4 concentration and caucasians and american blacks with normal or reduced s ... | 1985 | 3928734 |
| variant thyroxine-binding globulin in serum of australian aborigines: a comparison with familial tbg deficiency in caucasians and american blacks. | about 40% of clinically euthyroid australian aborigines have low concentrations of total thyroxine (tt4) and triiodothyronine (tt3) in serum. while the finding of normal concentrations of serum thyrotropin (tsh) in such individuals is compatible with their eumetabolic state, the reason for the finding of a low free t4 index (ft4i) has been unclear. a genetic variant of t4-binding globulin (tbg) with reduced affinity for t4 has been suggested but decrease in the absolute concentration of tbg has ... | 1985 | 3928733 |
| long term treatment of graves' hyperthyroidism with sodium ipodate. | to investigate the long term usefulness of sodium ipodate (oragrafin) in the management of graves' hyperthyroidism, we studied the effects of ipodate (500 mg, orally, daily for 23-31 weeks) on serum t3, t4, rt3, and some clinical parameters in five newly diagnosed graves' hyperthyroid patients. mean pretreatment serum t3, t4, and rt3 concentrations were 780 ng/dl, 25.4 micrograms/dl, and 118 ng/dl, respectively. one day after the first dose of ipodate, serum t3 decreased by 62% (p less than 0.01 ... | 1985 | 3928675 |
| limited external irradiation and interstitial 192iridium implant in the treatment of squamous cell carcinoma of the tonsillar region. | between january 1976 and march 1982, 80 patients with histologically proven diagnosis of squamous cell carcinoma of the tonsillar region were treated with definitive radiotherapy. sixty-five (81%) of these patients had locally advanced tumors (stage iii and iv); 49% of patients had clinically palpable cervical lymphadenopathy. all patients received a combined external megavoltage and interstitial irradiation. the dose of external irradiation was limited to 4500-5000 cgy over 41/2 to 51/2 weeks. ... | 1985 | 3928545 |
| the lymph node in mycosis fungoides: a light and electron microscopy and immunohistological study supporting the langerhans' cell-retrovirus hypothesis. | this paper describes the light and electron microscopy and monoclonal antibody findings in the lymph nodes of nine patients with mycosis fungoides. four cases showed dermatopathic change characterized by close association between small convoluted t4 lymphocytes and t6 antigen-presenting cells (langerhans' and indeterminate dendritic cells) in the sinuses and paracortical zones. the t4:t8 ratio was between 3 and 5:1. one case showed dermatopathic change but included large convoluted t4 lymphocyte ... | 1985 | 3928479 |
| activity of the hypothalamo-pituitary axis and testicular development in prepubertal ram lambs with induced hypothyroidism or hyperthyroidism. | prepubertal (16 weeks old) ram lambs were used to investigate the effects of hyperthyroidism and hypothyroidism on development of reproductive endocrine function. over a period of 8 weeks, ram lambs were made hypothyroid (serum t4 less than or equal to 3 ng/ml compared with controls congruent to 30 ng/ml) by daily oral administration of methyl thiouracil or hyperthyroid (serum t4 congruent to 135 ng/ml) by daily sc injection of t4. hyperthyroidism was associated with decreases in lh pulse freque ... | 1985 | 3928336 |
| ontogeny of human t and b lymphocytes during stressed and normal gestation: phenotypic analysis of umbilical cord lymphocytes from term and preterm infants. | cord blood lymphocytes from premature and stressed term infants were phenotyped and contrasted with t and b lymphocytes from healthy newborns at term. cytofluorometric analysis shows that in the early third trimester, 80-85% of fetal t cells belong to the t4+ inducer population, and 10% to the t8+ suppressor/cytotoxic subset. as gestation progresses, the t4:t8 ratio shifts toward adult values and there is an increase in expression of the mature antigen, t12. the b-cell-differentiation antigens b ... | 1985 | 3928218 |
| persistent trh-induced growth hormone release after short-term and long-term l-thyroxine replacement therapy in primary congenital hypothyroidism. | no appreciable changes in plasma gh levels after trh stimulation have been observed in normal subjects, whereas acute gh release has been reported in primary hypothyroidism and other pathophysiological states. to evaluate the effect of the t4 replacement therapy on trh-induced gh release, 28 patient volunteers with primary congenital hypothyroidism (pch), were studied before (11 subjects), after 1 month (nine subjects) and after long-term t4 replacement therapy (eight subjects). all patients und ... | 1985 | 3928212 |
| improved control in advanced head and neck cancer with simultaneous radiation and cisplatin/5-fu chemotherapy. | chemotherapy with cisplatin plus 5-fu infusion was given simultaneously with radiation therapy; both were administered every other week. twenty-seven patients with stage iv disease and three with stage iii disease were treated; 57% had t4, 33% had n3, and 10% had m1 disease. of these patients, 17 (57%) achieved complete response and the rest achieved partial response. however, whether or not a clinically complete response occurred had no effect on subsequent risk for disease recurrence. with a m ... | 1985 | 3928158 |
| [light entrainment and stimulation of the secretion of prolactin in rams]. | light entrainment and stimulation of prl release were studied in rams submitted to artificial light regimes: in a first experiment four groups of animals were submitted to light regimes with a period of 6, 4, 3 or 2 months respectively (t6 to t2 groups) and amplitude of 8-16 h of daylength. in all four groups prl level was significantly correlated with daylength (r greater than 0.51; p less than 0.01). however in july, when temperatures were indeed high, an additional prl increase was observed i ... | 1985 | 3928108 |
| the diagnostic challenge of euthyroid hyperthyroxinemia. | in euthyroid hyperthyroxinemia high levels of thyroxine (t4) may be either transient or persistent, associated with high, normal, or low levels of tri-iodothyronine (t3). euthyroid hyperthyroxinemia may occur: as a response to abnormal plasma binding (thyroxine binding globulin, albumin, prealbumin, or autoantibodies), because of hormone resistance, after exposure to drugs such as amiodarone, cholecystographic contrast agents, or propranolol, during acute psychiatric illness or stress, and in hy ... | 1985 | 3927889 |
| thyrotropin-releasing hormone stimulation testing in healthy dogs. | serum triiodothyronine (t3) and thyroxine (t4) concentrations were determined after iv administration of 200 micrograms of thyrotropin-releasing hormone (trh) to 10 healthy euthyroid dogs. significant (p less than 0.05) changes were not found in the t3 concentration throughout an 8-hour sampling interval. all dogs had a significant increase (p less than 0.05) in the t4 concentration at 4, 5, 6, 7, and 8 hours after trh administration. the largest increase in the serum t4 concentration occurred 4 ... | 1985 | 3927801 |
| thymulin (zn-facteur thymique serique) activity in anorexia nervosa patients. | thymulin (or fts-zn) a well-defined thymic hormone was studied in fifteen female patients hospitalized for anorexia nervosa. the circulating hormone was measured together with the plasma levels of thyroid hormones, cortisol and zinc. thymulin activity determined by the rosette assay was significantly reduced in the anorexia nervosa patients compared to sex- and age-matched healthy control subjects. the patients were characterized by very depressed plasma levels of triiodothyronine (t3) but exhib ... | 1985 | 3927699 |
| [correlation between the thyroxine, 17-beta-estradiol and luteinizing hormones in the systemic circulation and the rectal and vaginal temperature in heifers and cows after administration of cloprostenol]. | changes in the concentration of 17beta-oestradiol (e2) and luteinizing hormone (lh) and in the rectal and vaginal temperatures (rt and vt) were studied along with the changes in thyroxine concentration (t4) in three cows and three heifers in the luteal stage of the cycle; the animals had been intramuscularly treated with 2 ml oestrophan (cloprostenol). the closeness of the correlation between t4 and the remaining parameters under study was determined by the calculation of the correlation coeffic ... | 1985 | 3927552 |
| effect of trh on tsh and prolactin levels in affective disorders. | the thyrotropin-releasing hormone (trh) test was studied in 32 patients with acute major depressive disorder, 16 patients with recurrent unipolar (n = 8) or bipolar (n = 8) affective disorder in remission, and 22 healthy control subjects. twenty-six of the 32 acutely ill patients were also studied when in remission. outcome in these patients was correlated to serum levels of triiodothyronine (t3), 3,3',5'triiodothyronine (reverse t3), thyroxine (t4), thyroid-stimulating hormone (tsh), prolactin ... | 1985 | 3927333 |
| effect of propranolol on thyroid homeostasis of healthy volunteers. | the effect of propranolol on thyroid status was investigated by administering the drug in 2 therapeutic doses (80 mg b.d. and 120 mg b.d.) to 8 healthy volunteers and serially measuring total and free thyroid hormones and their major binding protein. mean free t3 fell by 1.2 pmol/l (p less than 0.05) whilst mean free t4 and mean rt3 rose by 3.3 pmol/l (p less than 0.01) and 0.16 nmol/l (p less than 0.01) respectively. mean thyroxine binding globulin (tbg) fell by 1.2 mg/l (p less than 0.001). de ... | 1985 | 3927277 |
| comparison of the ability of thyroxine and triiodothyronine to suppress trh-induced tsh secretion by perfused rat anterior pituitary fragments. | adenohypophyseal fragments from 8 rats were perifused in small 0.2-ml chambers with medium alone or with medium containing 0.2 or 2 micrograms/dl t3 or 20 micrograms/dl t4. the tsh secretion in response to 1-min perifusion with 3 x 10(-8) m trh was measured before and at 20- to 40-min intervals after beginning t4 or t3 perifusions. a similar temporal course of inhibition of trh-induced tsh secretion was produced by both iodothyronines, suggesting but not proving that t4 may inhibit the tsh secre ... | 1985 | 3927182 |
| evidence for expansion of a population of lymphocytes with reduced or absent t3 expression in aged human donors. | in a previous report, we described an unusual pattern of t cell associated surface marker expression in unfractionated mononuclear cells from aged donors; an excess of t4 and t8 positive cells relative to t3 positive cells. this study further characterizes these cells on the basis of density, adherence to nylon wool and quantitative expression of cell surface markers. we find that the population of lymphocytes responsible for the unusual surface marker expression is of low density, adheres to ny ... | 1985 | 3927075 |
| [evaluation of combined radiotherapy of gastric carcinoma]. | combined radiotherapy with chemotherapy was performed on 82 patients with advanced gastric carcinoma (t2-t4: m0). a small target volume, including the primary lesion and regional lymph nodes (n1), was irradiated with the dose of 60 gy. the survival rate was 21% at two years and 6% at five. the prognosis was better in cases of less advanced carcinoma, types i and ii carcinoma and radioresponsive tumor. as the conclusion, it was suggested that this combination therapy could be curative in a few pa ... | 1985 | 3927034 |
| effect of carbadox on growth, fasting metabolism, thyroid function and gastrointestinal tract in young pigs. | five experiments were done with 34 weanling and 24 growing crossbred gilts. individually penned pigs were fed ad libitum (expt 1) or pair-fed (expt 2 through expt 5) for either 2 (expt 1 through expt 4) or 3 (expt 5) wk. mean body weight gain and gain/feed values were significantly (p less than 0.05) greater in pigs fed carbadox (a synthetic antimicrobial). fasting o2 consumption and co2 production of pigs were measured during the 32- to 48-h (expt 1, 4 and 5) or during the 24- to 40-h (expt 2 a ... | 1985 | 3926967 |
| human lymphocyte responses to hepatitis a virus-infected cells: interferon production and lysis of infected cells. | peripheral blood mononuclear cells (pbmc) from nonimmune healthy donors who did not have antibody to hepatitis a virus lysed hepatitis a virus-infected bs-c-1 cells to a greater degree than uninfected bs-c-1 cells. the predominant effector cells were contained in the nonadherent peripheral blood lymphocyte (pbl) fraction, although some lytic activity was associated with adherent cells. characterization of the pbl with monoclonal antibodies showed that the responsible effector lymphocytes were co ... | 1985 | 3926897 |
| mechanism of accessory cell requirement in inducing il 2 responsiveness by human t4 lymphocytes that generate colonies under pha stimulation. | pha-driven monoclonal colony formation by low concentrations of resting t4 lymphocytes in agar culture requires the presence of interleukin 2 (il 2) and accessory cells. using recombinant il 2 and anti-tac monoclonal antibody as a probe for the il 2 receptor, we demonstrate that the requirement of accessory cells (here an irradiated b cell line) in inducing il 2 responsiveness relies on their enhancing effect in functional il 2 receptor expression by the t colony progenitors. furthermore, it is ... | 1985 | 3926884 |
| human t cell antigen expression during the early stages of fetal thymic maturation. | human thymus tissue was examined from 7 wk of gestation through birth for the expression of antigens reacting with a panel of anti-t cell monoclonal antibodies. additionally, the reactivities of reagents against the transferrin receptor, against leukocytes, against low m. w. keratins, and against major histocompatibility complex antigens were studied on human fetal thymic tissue. frozen tissue sections were evaluated by using indirect immunofluorescence assays. at 7 wk of gestation, no lymphoid ... | 1985 | 3926883 |
| differentiation and activation phenotypes of lung t lymphocytes differ from those of circulating t lymphocytes. | we used dual laser two-color flow cytometry to compare the expression of surface markers associated with activation and with differentiation in lung and peripheral blood t lymphocytes from normal subjects. t cell subsets, defined based on their reactivity with monoclonal antibodies (mab) okt3, okt4, and okt8, were analyzed for expression of activation antigens as detected by mabs to the interleukin-2 receptor, the transferrin receptor, and hla-dr determinants. whereas circulating t lymphocytes e ... | 1985 | 3926821 |
| growth enhancement by dopaminergic therapy in children with intrauterine growth retardation. | in a previous study we reported stimulation of growth velocity in hypopituitary children by dopaminergic therapy (da), i.e. either l-dopa or bromocriptine. the purpose of the present study was to determine if da stimulated endogenous gh release and growth in children with intrauterine growth retardation (iugr), who also had microcephaly and psychomotor retardation. the effect of da on serum lh, fsh, gonadal steroids, cortisol, t4, and tsh also was examined. six prepubertal children [four girls a ... | 1985 | 3926809 |
| blunted growth hormone (gh) response to gh-releasing hormone in hypothyroidism resolves in the euthyroid state. | gh secretion is dependent upon thyroid hormone availability. in this study, the gh response to gh-releasing hormone (ghrh) was studied in a group of patients when they were hypothyroid and also when they were euthyroid. hypothyroidism was associated with a significant reduction in both the peak gh response and the integrated gh secretory response to ghrh compared to those in the euthyroid state [4.7 +/- 1.6 (+/- sem) vs. 12.2 +/- 3.9 ng/ml (p less than 0.025), and 349 +/- 116 ng vs. 986 +/- 304 ... | 1985 | 3926807 |
| patterns of failure in carcinoma of the nasopharynx: i. failure at the primary site. | between 1970 and 1980, we treated 107 previously untreated patients with biopsy proven carcinoma of the nasopharynx by megavoltage external radiation therapy to the primary site, base of the skull and both sides of the neck. fifty-three percent of the patients had t4 primaries and 87% had stage iv disease. the histology was poorly differentiated, undifferentiated or anaplastic carcinoma in 81% of the patients, and well differentiated or moderately well differentiated epidermoid carcinoma in 19%. ... | 1985 | 3926733 |
| seasonal cycles in testicular activity, gonadotropin, and thyroxine in the painted turtle, chrysemys picta, under natural conditions. | plasma levels of testosterone (t), thyroxine (t4) and follicle-stimulating hormone (fsh) were measured in a field population of the painted turtle, chrysemys picta, in michigan. all three hormones showed pronounced seasonality; plasma luteinizing hormone (lh) remained nondetectable. plasma t and fsh concentrations were highly correlated and exhibited biphasic cycles with peaks in spring and fall, whereas t4 showed a single peak in summer, coincident with the nadir in t. hormone levels were minim ... | 1985 | 3926601 |
| radioimmunoassay of thyroxine in saliva. | a simple radioimmunoassay (ria) for thyroxine (t4) in saliva has been described. fifty euthyroid control subjects, 14 euthyroid pregnant women, 23 thyreotoxic and 10 hypothyroid patients were examined. serum t3, t4, thyroxine binding globulin (tbg) and tsh were measured simultaneously. the mean level of t4 in saliva in controls was 1.10 +/- 0.07 nmol/l. there was a good correlation between the saliva and serum t4 concentrations (r = 0.74) and between saliva t4 values and the t4/tbg ratio (r = 0. ... | 1985 | 3926523 |
| effect of prednison therapy on serum levels of thyroxine (t4), triiodothyronine (t3), reverse triiodothyronine (rt3), t3-binding capacity, basal tsh level and tsh response to thyreoliberin (trh) in children. | effects of prednison therapy on serum levels of t4, t3, rt3, tbc, basal tsh and tsh response to trh in 10 children (7 with nephrotic syndrome, 3 with trombocytopenia) were studied. it has been found out that corticotherapy (prednison 1--2 mg/kg/24 h; 2--4 weeks) causes a significant decrease of total t3 concentration together with a considerable rise of reverse t3 and lower t3-binding capacity. basal tsh level was increased about twice; tsh response to trh between both groups (without and with p ... | 1985 | 3926522 |
| effects of trh and a rat tsh preparation on discrete hypothalamic and forebrain catecholamine nerve terminal networks in the hypophysectomized male rat. | a rat pituitary tsh preparation in doses of 10 and 100 micrograms/kg produced rapid and marked increases in dopamine (da) levels and alpha-methyltyrosine-induced decline consistent with increased da synthesis and release in the medial and lateral palisade zones (mpz, lpz) of the median eminence, and reduced noradrenaline (na) turnover in the paraventricular hypothalamic nucleus (pa) of the hypophysectomized male rat. the tsh serum levels measured in these rats 2 h after the injection were within ... | 1985 | 3926514 |
| effects of exposure of pregnant rats to trh on development of the pituitary-thyroid axis in their progeny. | trh (10 and 1000 micrograms/kg body weight (bw] was injected ip into pregnant rats daily from day 0 to 20 of pregnancy, and the pituitary-thyroid axis of their pups (mat-trh rats) was examined on days 0, 4, 10, 21 and 90 after birth. the pituitary tsh content of male mat-trh rats was significantly lower on day 4, and higher on day 10 than that of control rats. the serum tsh was significantly higher on day 10 (except female 10 micrograms/kg group). an exaggerated tsh response to exogenous trh (10 ... | 1985 | 3926475 |
| effects of food deprivation on the feedback regulation of the hypothalamic-pituitary-thyroid axis of the rat. | we have studied the effects of food deprivation on the plasma concentrations of t4, t3, and tsh, the tsh mcr, the pituitary tsh content, and the pituitary tsh response to trh in female rats. two days before the beginning of the experiment all rats were prepared with chronic intraatrial catheters through which trh (100 ng/100 g bw) or [125i]iodo-tsh was administered, and sequential blood samples were obtained. the plasma concentrations of t4 and t3 in food-deprived rats were significantly (p less ... | 1985 | 3926471 |
| protein utilization in growth: effect of lysine deficiency on serum growth hormone, somatomedins, insulin, total thyroxine (t4) and triiodothyronine, free t4 index, and total corticosterone. | we have studied the effect of a lysine-deficient diet on the growth of young rats and on serum levels of gh, somatomedins [insulin-like growth factors (igfs) i and ii], insulin, total t4 and t3, free t4 index, and total corticosterone. rats eating a wheat gluten diet consumed about one third as much lysine as controls eating an isocaloric and isonitrogenous casein diet and grew at approximately 56% of the control rate. the mean (+/- sem) gh level in the experimental group (68 +/- 9 ng/ml) was si ... | 1985 | 3926459 |
| thyroid hormone-binding inhibitor in normal, pregnant, and lactating rat and postmenopausal human breast tissue. | the regulatory role of thyroid hormones in the synthesis of milk proteins and functional differentiation of the murine mammary gland has been demonstrated. further, t4 and t3 and their metabolites are found in both rat and human milk. since the enhanced metabolic demands of mammo- and lactogenesis may result in increased local hormonal requirements, we examined breast tissue from normal (virgin), pregnant, and lactating female rats, as well as postmenopausal human breast tissue for the presence ... | 1985 | 3926454 |
| an evaluation of a fluorescence polarization immunoassay of thyroxin and thyroxin-uptake. | we evaluated the fluorescence polarization immunoassay for total thyroxin (t4) and thyroxin-uptake (t-u) in the abbott "tdx" analyzer. between-assay precision was good when we did once-fortnightly calibration and assayed samples in singleton. measured t4 concentration was decreased in hemolyzed samples with obvious red coloration and undetectable in severely hemolyzed samples. the t-u assay was unaffected by hemolysis. unlike the triiodothyronine-uptake methods, the t-u assay utilizes labeled t4 ... | 1985 | 3926346 |
| raised plasma glutathione s-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage. | using plasma glutathione s-transferase measurements hepatocellular integrity was assessed in groups of hyperthyroid and hypothyroid patients before and after treatment. ten of 14 hyperthyroid patients had clearly raised plasma glutathione s-transferase values at presentation and in each patient treatment with either iodine-131 or carbimazole resulted in a significant fall in glutathione s-transferase. the eight hypothyroid patients had normal glutathione s-transferase values at presentation and ... | 1985 | 3926229 |
| 5,6-dihydroxyindole oxidation by mammalian, mushroom and amphibian tyrosinase preparations. | the oxidation of 5,6-dihydroxyindole by tyrosinases from mushroom, harding-passey melanoma, bovine eye and bufo bufo embryo has been investigated. the apparent km values for this substrate were measured and found to be of the same order of magnitude as those for l-tyrosine and l-3,4-dihydroxyphenylalanine, as reported in the literature (5 x 10(-4) m). the 5,6-dihydroxyindole oxidases of mushroom and t4 melanoma isozyme are sensitive to phenylthiourea, while, on the other hand, those from crude p ... | 1985 | 3926006 |
| recent advances of ultrastructural immunocytochemistry of epidermal langerhans cells. | using electron microscopy, the immunological visualization of the membrane antigens of langerhans cells (lc) can be performed by immunoperoxidase and immunogold techniques. the immunoperoxidase labelling permits the identification of only one antigen and the observation of qualitative variations of surface antigens. the immunogold method allows the identification of one antigen or simultaneously two or three surface antigens using gold particles of various sizes. this technique can be used to qu ... | 1985 | 3925979 |
| lymphocyte subset ratios and factor viii usage in haemophilia. | type and quantity of replacement treatment, together with haematological and immunological parameters were determined in 37 boys with severe haemophilia a and 41 children with other bleeding disorders. the quantity of factor viii concentrate given to boys with severe haemophilia a (mean u/year) showed a significant inverse correlation with total white cell counts, lymphocyte counts, platelet counts, and the ratio of monoclonal antibody defined t lymphocyte subsets, t4 and t8 (t4:t8). of the boys ... | 1985 | 3925894 |
| sequential changes in the pituitary thyroid axis after chronic trh administration: effects on euthyroid and thyroxine treated female rats. | the effect of chronic oral thyrotrophin-releasing hormone (trh) administration on thyrotrophin (tsh), l-triiodothyronine (t3) and l-thyroxine (t4) serum levels, pituitary tsh concentration and serum response to acute trh injection, has been studied in female rats under different thyroidal conditions: sham-operated control animals, and thyroidectomized animals receiving 25 micrograms l-t4/100 g body weight/day. after 30 days, these groups were divided into two subgroups (6-10 animals per group), ... | 1985 | 3925674 |
| effects of oestradiol benzoate on the pituitary secretion and peripheral kinetics of thyrotrophin in the rat. | previous works from this laboratory have demonstrated that oestradiol benzoate (eb) in euthyroid male and female rats induced a significant decrease in the pituitary content of tsh while serum levels of this hormone remained normal. the present work studied the effects of eb (25 micrograms/100 g body weight, during 9 days) on the peripheral metabolism of [125i]rtsh and on the pituitary and plasma concentration of tsh in euthyroid and hypothyroid rats. no significant variations were observed in [ ... | 1985 | 3925673 |
| host transfer rna cleavage and reunion in t4-infected escherichia coli ctr5x. | t4 mutants lacking polynucleotide kinase (pnk-) or rna ligase (rli-) do not grow on e. coli ctr5x. during the abortive infections there accumulate host trna fragments that match into two species severed 3' to the anticodon. the ctr5x-specific fragments appear only transiently with wt phage, implicating the affected enzymes in phosphoryl group rearrangement and religation [david et al. (1982) virol. 123, 480]. in a search for the vulnerable host trnas and putative religation products, trna ensemb ... | 1985 | 3925439 |
| the effect of serum dilution on free thyroxine (t4) concentration in the low t4 syndrome of nonthyroidal illness. | progressive dilution of normal sera causes little change in free t4 concentrations. similar dilution of sera containing drug inhibitors of t4 binding to serum proteins causes a progressive fall in free t4. the low t4 syndrome of nonthyroidal illness is thought to be associated with a circulating inhibitor(s) of t4 binding. it would be expected, therefore, that dilution of sera from the low t4 syndrome might also result in a fall in free t4 concentrations. we compared the effect of progressive se ... | 1985 | 3924947 |
| nucleotide sequence of the thymidylate synthetase gene (thyp3) from the bacillus subtilis phage phi 3t. | the thyp3 gene, encoding thymidylate synthetase, from the bacillus subtilis phage phi 3t has been cloned and the nucleotide sequence determined. the derived amino acid sequence indicates a subunit mr of 32 748. the primary amino acid sequence is compared with the sequences of the analogous proteins specified by escherichia coli (thya), lactobacillus casei, (thya) and phage t4 (td). extensive conservation exists in all four sequences implying a shared tertiary structure. | 1985 | 3924741 |
| thyroid hormone binding in serum of 15 vertebrate species: isolation of thyroxine-binding globulin and prealbumin analogs. | the binding of [125i]t4 to serum proteins was studied in human, monkey, cattle, sheep, goat, water buffalo, horse, swine, dog, cat, rabbit, rat, chicken, frog, and salmon. attempts were made to isolate thyroxine-binding globulin (tbg) and thyroxine-binding prealbumin (tbpa) from serum of all species, utilizing purification methods based on the specific properties of these proteins. tbpa was found to exist in all species examined. the protein was found anodal to albumin only in human, monkey, hor ... | 1985 | 3924724 |
| human clones with natural killer function can activate b cells and secrete b cell differentiation factors. | large granular lymphocyte clones were prepared from normal human mononuclear cells. seven clones were studied in detail. all had high cytotoxic activity against the natural killer (nk) cell target k562 and all were t11- and dr-positive but t4- and t8-negative: none released migration inhibitory factor, a characteristic of helper t cell clones. when these nk cell clones were co-cultured with autologous b cells in a 1:1 ratio, 4 of the 7 induced both igm and igg synthesis. ig production could not ... | 1985 | 3924630 |
| growth hormone response to thyrotropin-releasing hormone in the urethane-anesthetized rat: effect of thyroid status. | to evaluate the role of thyroid hormones in regulation of the gh-stimulatory effects of trh and human pancreatic gh-releasing factor (hpgrf-40), we studied the plasma gh responses to these secretagogues under conditions of thyroid hormone deprivation and replacement in the urethane-anesthetized rat. in euthyroid control rats, trh (1 microgram/kg) elicited a small transient rise in plasma gh, which peaked at 2-5 min and returned to basal by 20 min. in chronically hypothyroid rats (10 weeks after ... | 1985 | 3924582 |
| clinical chemistry in women treated with six levonorgestrel covered rods or with a copper iud. | a group of women treated with six levonorgestrel covered rods participated in a study on general chemistry and blood levels of selected hormones at treatment months 20 and 65. a comparable group of copper t users served as control. parameters analyzed were the sma 12 chemistry profile, estradiol, testosterone, cortisol, t3, t4 and tsh. samples from treated and control subjects were drawn within the same calendar period and were run simultaneously for the assay of each parameter. the values obser ... | 1985 | 3924475 |
| phenotypic and functional heterogeneity of human t lymphocytes producing b-cell growth factor(s): a clonal analysis. | human t cells active on b-cell proliferation are phenotypically and functionally heterogeneous. a series of 43 human t-cell clones, selected according to their ability to release factors active on b-cell proliferation, were analyzed. b-cell proliferation was evaluated by two different assays, namely, a costimulation assay with anti-mu antibody or by an assay based on b-cell preactivation with staphylococcus aureus. eight of these clones expressed the t4-/t8+ phenotype while the remaining were t4 ... | 1985 | 3924456 |
| endocrine activity in preterm and full-term lambs. 1. adrenal response to synacthen. 2. thyroid response to ovine thyroid-stimulating hormone or thyrotropin-releasing hormone. | neonatal endocrine status was studied in 14 lambs born 7 days before term, after estrogen injection into the ewes, and in 15 full-term animals. plasma cortisol and triiodothyronine (t3) levels were depressed during the first hours of life in preterm lambs and plasma reverse t3 levels were significantly higher than in controls. the rise in plasma cortisol levels after synacthen injection was significantly lowered by prematurity, suggesting reduced sensitivity of the adrenal cortex to acth. after ... | 1985 | 3924127 |
| genetics and clinical significance of thyroxine binding globulin deficiency, an analysis of seven families. | seven families, ascertained through probands with undetectable levels of thyroxine binding globulin (tbg) were studied from clinical and genetic points of view. the blood levels of tbg, thyroxine binding prealbumin (tbpa), thyroid-stimulating hormone (tsh), triiodothyronine (t3), and thyroxine (t4) were determined in altogether 128 family members. the concentration of free thyroxine (ft4) was calculated from the concentrations of t4, tbg and tbpa. only men (n = 15) were found to have total tbg d ... | 1985 | 3923758 |
| influence of extradural blockade on serum thyroid hormone concentrations after surgery. | to study the changes in thyroid hormone metabolism after surgery, the influence of neurogenic blockade by extradural local anaesthetics, and possible hormonal interactions, 16 women undergoing cholecystectomy were randomly allocated to two groups of eight each. all patients received general anaesthesia and in addition one group received extradural blockade for 24 h. preoperatively and at 2, 4, 6, 12 and 24 h after skin incision arterial serum concentrations of thyroid hormones (t3, free t3, rt3, ... | 1985 | 3923748 |
| [methods and clinical evaluation of a new enzyme immunologic method for determination of thyroxin binding globulin (tbg) and t4/tbg quotient: a multicenter study]. | a heterogeneous enzyme immunoassay for the determination of thyroxine binding globulin (tbg) was developed and assessed in clinical trials in 12 laboratories. the assay is based on the competition principle and employs plastic tubes coated with goat anti-tbg. cv's between 1.4-8.9% for intra-assay precision and 2.9-8.6% for inter-assay precision were found over the concentration range of 4-40 mg/l tbg. in comparative studies using highly purified tbg as standard, values with enzymun-test tbg were ... | 1985 | 3923151 |
| characterization of a t4+/leu-8+ t cell clone that directly helps b cell ig production by secreting b cell differentiation factor. | a human t4+/leu-8+ t cell clone (ya2) was established by phytohemagglutinin activation and interleukin 2 (il 2) propagation. functional characterization of this clone demonstrated that it provided potent help towards ig production by pokeweed mitogen-stimulated b cells in the presence of small numbers of autologous t cells or by staphylococcus aureus cowan i (sac)-activated b cells in the presence of b cell growth factor (bcgf). ya2 provided no help to resting b cells and minimal help to either ... | 1985 | 3923106 |
| disparity of thyrotropin (tsh) and prolactin responses to tsh-releasing hormone in obesity. | the effect of trh administration on tsh and prl release was investigated in 11 obese women and 16 normal weight women. there were no differences in basal serum levels of estradiol, t3, t4, tsh, or prl between the 2 groups. the increment of tsh levels in the obese group [mean maximum change (delta max), 19.3 +/- 3.0 (+/-sem) miu/liter] was significantly higher (p less than 0.025) than that in the control group (delta max, 11.3 +/- 1.3 miu/liter), whereas prl levels rose significantly less (p less ... | 1985 | 3923032 |
| association of melasma with thyroid autoimmunity and other thyroidal abnormalities and their relationship to the origin of the melasma. | melasma is localized hyperpigmentation over the forehead, upper lips, cheeks, and chin. in this study, evidence suggesting an association between autoimmune thyroid disorders and melasma and the relationship of thyroid disorders to the origin of melasma is presented. a total of 108 nonpregnant women, aged 20-56 yr, were divided into 2 groups for the purpose of this study: 1) melasma, 84 patients; 2) control group, 24 patients from the dermatology clinic matched for age and sex. microsomal thyroi ... | 1985 | 3923030 |
| caloric restriction does not alter thyrotropin secretion in hypothyroidism. | the effect of caloric restriction, as a model of nonthyroid illness, on serum thyroid hormone and tsh concentrations in hypothyroid patients was studied to determine if pituitary-thyroid function is altered in such patients, as it is in euthyroid subjects. serum t4, t3, and tsh concentrations and serum tsh responses to trh were measured in 5 untreated hypothyroid patients and 10 hypothyroid patients receiving t4 replacement therapy before and after restriction of caloric intake to 500 cal daily ... | 1985 | 3923016 |
| prolactin and thyrotropin response to thyrotropin-releasing hormone in premenopausal women with fibrocystic disease of the breast. | plasma prl, tsh, total and free t4, total and free t3, and 17 beta-estradiol were evaluated in 29 premenopausal women with well-documented fibrocystic disease of the breast and in 29 healthy matched controls. plasma prl and tsh dynamics after acute trh injection (200 micrograms i.v.) were also determined. all hormonal measurements were performed in the follicular phase of the menstrual cycle. neither patients nor controls showed any thyroid function impairment. basal plasma levels of the examine ... | 1985 | 3922866 |
| low thyroidal t3 in nodular goitrous tissue. | six nodular tissues of non-treated and four of treated patients (suppressive treatment with thyroid hormones from three months to two years until the operation) with nodular non-toxic goitre contained low t3 (less than 1 ug/g w.w.). the results of iodothyronines and thyroglobulin (tg) were compared with respective tissues containing t3 greater than 1 ug/g w.w. in non-treated patients, nodular tissues with low t3 and very high t4/t3 ratio showed t4 and tg concentrations not different from the tis ... | 1985 | 3922865 |
| functional specificity of gonadotropin and thyrotropin in fundulus heteroclitus. | gonadotropic hormones (gths) and thyrotropic hormones (tshs) reportedly bear close evolutionary and structural relationships, and the thyroid appears to be active in reproduction in some fish species. we tested the sensitivity of the thyroid of fundulus heteroclitus to glycoprotein hormones from mammalian and piscine sources. six mammalian glycoprotein hormones, including four gonadotropins and two thyrotropins, produced dose-dependent elevations in serum thyroxin. a release of endogenous gonado ... | 1985 | 3922851 |
| effects of anticonvulsant monotherapy in pregnancy on the newborn endocrine system. preliminary data. | pituitary-thyroid axis function and gonadotropin secretion were evaluated by a combined trh and lhrh test in 4 newborn female infants appropriate for gestational age of mothers treated by aeds throughout pregnancy. we found: high basal fsh levels with normal fsh reserve, normal lh-hcg levels both before and after lhrh stimulation, normal tsh and t4 levels both before and after trh stimulation, high t3 basal values with a normal increase after trh and low rt3 basal values. it is suggested an aed ... | 1985 | 3922390 |
| effects of chronic anticonvulsant monotherapy on endocrine system in prepubertal children with convulsive disorders. preliminary data. | effects of phenobarbital (pb), carbamazepine (cbz) and sodium valproate (vpa) monotherapy on endocrine functions were investigated in 7 clinically prepubertal children aged 5-10 8/12 years. the following meaning results were observed: normal prl release, low basal t4 levels in pb-, cbz-treated children and normal t4 basal level in the vpa-treated child; normal t3, rt3, tbg and tsh basal values and normal tsh release in all treated children, normal fsh release in pb-, cbz- and vpa-treated females ... | 1985 | 3922389 |
| transport of thyroxine bound to human prealbumin into rat liver. | the transport into rat liver of thyroxine (t4) bound to human prealbumin was studied with the use of sera obtained from patients with thyroid hormone-binding globulin (tbg) deficiency and with purified human prealbumin. the unidirectional extraction of 125i-t4 by liver was measured after rapid injection of isotope mixed in human serum into the portal vein of ketamine-anesthetized rats. the percentage of total serum t4 transported into liver was 47.6 +/- 5.2% in subjects with tbg deficiency, and ... | 1985 | 3922231 |
| phenotypic and functional heterogeneity of human t cell clones producing gamma-interferon. | human t cell clones were derived from peripheral blood and screened for their ability to release gamma-interferon (gamma-if) following pha stimulation. nine clones producing more than 20 u/ml of gamma-if were expanded and analyzed for cytolytic activity in a lectin-dependent assay and for the ability to release interleukin-2 (il-2). in addition, clones were analyzed for t4 and t8 antigen expression. five out of nine clones had cytolytic t lymphocyte activity, while four released relatively large ... | 1985 | 3922041 |
| a prospective study of the effects of lithium on thyroid function and on the prevalence of antithyroid antibodies. | tests of thyroid function and pathology were carried out on 133 patients before they were treated with lithium (li+). of the 12 patients who subsequently became hypothyroid during treatment with lithium 9 had, before the commencement of treatment, thyroid autoantibodies and/or an exaggerated thyroid stimulating hormone (tsh) response to thyrotropin releasing hormone (trh), whereas 3 patients had neither of these indicators. lithium administration was accompanied by a rise in thyroid antibody tit ... | 1985 | 3922008 |
| thyroid function during the spontaneous course of subacute thyroiditis. | a study of changes in serum t4, t3, and tg as well as of serum tsh response to trh was done in ten patients with subacute thyroiditis, from the acute phase up to 56 mo. all patients had symptoms of thyrotoxicosis. the mean +/- s.e.m. serum t4 (21.6 +/- 8.2 micrograms/dl), t3 (315 +/- 191 ng/dl) and tg (149 +/- 52 ng/ml) concentrations were significantly higher than in normal subjects (8.5 +/- 1.7 micrograms/dl, 136 +/- 34 ng/dl, and 10.5 +/- 1.0 ng/ml, respectively). the basal tsh concentrations ... | 1985 | 3921671 |
| distinction between antigen receptor and il 2 receptor triggering events in the activation of alloreactive t cell clones with calcium ionophore and phorbol ester. | a previous study indicated that ca++ ionophores in conjunction with the phorbol ester 12-o-tetradecanoylphorbol 13-acetate (tpa) could induce normal t lymphocytes to express receptors for the t cell growth factor, interleukin 2 (il 2), to secrete il 2, and to proliferate (1). here we used long-term alloreactive lyt-2+ cytotoxic or t4+ "helper" t cell clones. in response to their specific alloantigen, all of the clones secreted ifn-gamma but only the t4+ clone secreted il 2 and proliferated in re ... | 1985 | 3921610 |
| comparative study of intravenous, nasal, oral and buccal trh administration among healthy subjects. | four different modes of trh application (400 micrograms iv, 1 mg nasal, 10 mg buccal and 40 mg oral) were investigated in young healthy subjects for evaluation of thyrotropin (tsh) and prolactin (prl) stimulation. plasma tsh, prl, t4, t3, thyroxine-binding-globulin (tbg) were measured by radioimmunoassay. there were significant increases of tsh and prl following trh stimulation by all test forms. bolus injection of trh led to maximal tsh and prl plasma levels within 20 min to 30 min, compared wi ... | 1985 | 3921595 |
| serum thyroxine and triiodothyronine concentrations in rats receiving lithium carbonate. | circulating thyroxine (t4) and triiodothyronine (t3) concentrations in rats were determined after various periods of lithium administration in diet. no significant change in serum t4 and t3 levels was observed after ten days of lithium treatment. however, lithium treatment for one month, two months and four months showed a significant decrease in serum t4 and t3 levels indicating the adverse effect of chronic lithium intake. | 1985 | 3921447 |
| hypothyroidism blunts the growth hormone (gh) releasing effect of human pancreatic gh releasing factor in the adult male rat in vivo and in vitro. | the effect of the 44-amino-acid peptide human pancreatic gh releasing factor (hpgrf-44) upon the secretion of gh was studied in control and hypothyroid adult male rats. in animals rendered hypothyroid by ingestion of propylthiouracil (ptu), basal and hpgrf-44-stimulated secretion of gh was depressed in vivo. administration of t4 together with ptu prevented the decline in basal and hpgrf-provoked gh secretion in vivo. hpgrf-44-stimulated release of rat gh was also impaired in vitro, an effect par ... | 1985 | 3921343 |
| conversion of thyroxine (t4) to t3 and rt3 in human leucocyte suspension: its application to clinical investigation. | the generation of t3 and rt3 from added nonradioactive t4 in human polymorphonuclear leucocytes was measured. the amounts of the t3 and rt3 generated were estimated by radioimmunoassay in healthy volunteers and patients suffering of thyroidal and nonthyroidal diseases. under the incubation conditions employed an increase of in vitro generation of t3 and rt3 was observed in suspensions of hyperthyroid patients, while a significant decrease was found when leucocytes from hypothyroid patients were ... | 1985 | 3921342 |
| the effect of propranolol on circulating thyroid hormone measurements in thyrotoxic and euthyroid subjects. | circulating concentrations of total and free thyroid hormones and thyroid hormone binding proteins were measured in thyrotoxic and euthyroid subjects treated with propranolol. in the thyrotoxic group, total triiodothyronine (t3) concentration fell after propranolol therapy, suggesting an effect of the drug on the peripheral conversion of thyroxine (t4) to t3. in euthyroid subjects, a rise in circulating concentrations of free t4 and reverse t3 (rt3) was observed, while only a small decrease in f ... | 1985 | 3920853 |
| [intranasal trh for the stimulation of hypophyseal and thyroid reserves. preliminary report]. | intranasal, intravenous and oral trh have been compared in 9 healthy volunteers. intranasal administration of trh leads to excellent stimulation of pituitary tsh secretion. serum tsh levels are significantly higher than after intravenous trh (p less than 0.005) and lower than after oral trh (p less than 0.005). as with intravenous trh, peak tsh response is reached at 20-30 minutes, but the stimulatory effect is prolonged and elevated tsh levels can be measured for up to 3 hours. stimulation of t ... | 1985 | 3920752 |
| squamous cell carcinoma of the anal canal: treatment by external beam irradiation. | external beam radiation therapy alone or in combination with curietherapy is the recommended treatment for anal canal carcinoma in some countries. in others, surgery is the sole accepted treatment. the results for 64 patients treated by external radiotherapy alone show excellent survival for stage t1t2 tumors but results are poor for large tumors (stage t4). the overall 5 year crude survival rate is 46%. the 5-year results are better for stage t1t2 (72%) than for stage t3t4 (35%). the presence o ... | 1985 | 3920734 |
| amiodarone-treated patients with suppressed tsh test are at risk of thyrotoxicosis. | therapeutic use of the potent antiarrhythmic drug amiodarone requires early detection of impending hyperthyroidism, a potentially life-threatening adverse reaction in cardiac patients. since amiodarone inhibits peripheral conversion of thyroxine (t4) to triiodothyronine (t3), serum t4 and t3 levels become unreliable parameters of thyroid function. in 44 patients treated with amiodarone for a median period of 7.3 months, up to seven trh-tsh tests were performed. the tsh response to trh was normal ... | 1985 | 3920432 |
| serum concentration of unsaturated thyroxine-binding globulin in hyper- and hypothyroidism. | the concentration of serum thyroxine (t4)-binding globulin (tbg) not binding t4 (unsaturated tbg, u-tbg) was determined in hyper- and hypothyroidism. u-tbg was expressed as the product of tbg concentration and the ratio of free tbg capacity to maximal tbg capacity as determined by reverse-flow electrophoresis. u-tbg concentration in normal sera (n = 40) was 15.5 +/- 2.3 mg/l (mean +/- sd), or 257 +/- 38 nmol/l for a molecular weight of tbg of 60 000 daltons. u-tbg levels were significantly lower ... | 1985 | 3919974 |