Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| numbers of rat dorsal root axons and ganglion cells during postnatal development. | the present study demonstrates that t4 and s2 rat dorsal root axons decrease significantly from birth to adulthood with almost all of the decrease occurring in the first two weeks of life. dorsal root ganglion cell numbers do not change during this time period. this is thus an example of postnatal axon elimination not associated with death of the cells that give rise to the axons. presumably this regressive process is important in the formation of the normal adult nervous system. in addition, th ... | 1986 | 3955377 |
| the effects of thyroxine treatment of rats on neuronal and extraneuronal uptake and metabolism of catecholamines in the heart. | the effects of thyroxine (t4) treatment of rats on the neuronal and extraneuronal uptake and subsequent metabolism of catecholamines in the heart were examined, to determine whether changes in the local dissipation of catecholamines might contribute to the enhanced sympathetic cardiac responses that occur when thyroid hormone levels are elevated. t4-treated rats were injected subcutaneously with l-thyroxine sodium 1 mg kg(-1) on days 1, 3 and 5, and controls were injected with the normal saline ... | 1986 | 3955305 |
| [seasonal characteristics of the effect of melatonin on thyroid function]. | changes in pituitary-thyroid axis sensitivity to bioactive component of pineal gland, melatonin, have been detected. in winter (short days) melatonin (100 micrograms/100 g of rat body weight) decreased t3 t4, tsh content and 131i uptake by thyroid tissue. however, it was noted that in summer (long photoperiod) the same injection caused suppression of t3 plasma level and 131i uptake ability of the thyroid gland, with t4 and tsh blood levels remaining significantly increased. | 1986 | 3955205 |
| natural killer cell response to regional lymph node metastases. | a determination of natural killer cell activity was performed in 67 individuals with advanced head and neck cancer. the mean activity of 28 patients clinically staged t3 no or t4 no was 81 +/- 11 lytic units (lu), significantly higher than 39 patients with palpable lymph node metastases (54 +/- 5 lu). assessing patients by extent of nodal disease revealed that activity actually increased, though not significantly, with progressive n-staging. a major determinate of increased natural killer cell c ... | 1986 | 3954896 |
| hyperfunctioning thyroid nodules in children and adolescents. | eight children and adolescents, seven female and one male, aged 7.1 to 15.0 years, referred over a 12-year period for a solitary mass in an otherwise normal thyroid gland, exhibited a hyperfunctioning nodule on thyroid scintiscan. tracer uptake in the surrounding thyroid tissue was reduced or completely suppressed, but could be restored after tsh stimulation. only one patient had mild clinical hyperthyroidism with normal t4 but increased t3 serum levels and blunted tsh responsiveness to trh. a s ... | 1986 | 3953267 |
| release of thyroid hormone from circulating thyroglobulin in the rat. | under normal conditions, a small amount of thyroglobulin (tg) exists in peripheral blood. however, the fate of circulating tg is unclear. in the present study, in vivo labelled rat tg was injected iv into rats whose thyroids had been blocked with ki to determine whether circulating tg released thyroid hormone by hydrolysis in extrathyroidal tissues. radiolabelled tg was obtained from thyroid of rats injected with 125i 24h before sacrifice, and subsequently purified by ammonium sulphate precipita ... | 1986 | 3953233 |
| thyroxine and triiodothyronine kinetics in cardiac patients taking amiodarone. | cardiac patients taking amiodarone, a potent anti-arrhythmic drug, often have supranormal serum thyroxine (t4) levels and normal or mildly reduced serum triiodothyronine (t3) levels. we studied t4 and t3 kinetics and conversion of t4 to t3 in 5 men with recurrent paroxysmal tachycardia before and after 5-6 weeks of therapy with amiodarone (dose 200-800 mg/day). the patients were also receiving various medicines for cardiac disease. each was injected with tracer doses of labelled t4 and t3; serum ... | 1986 | 3953231 |
| "the low t3 syndrome" and impaired thyroid protein synthesis in experimental trauma. | the thyroid response was evaluated in the present trauma model. trauma of varying severity was studied in 3 groups of anesthetized pigs. the animals were exposed to preparative surgery alone (n = 6) or followed by a standardized missile trauma to a hind leg (n = 10) or to the abdomen (n = 8). post-trauma observation for 24-48 hours under continuous anesthesia included measurements of circulating t4, t3 and rt3. the serum concentrations of t4 and t3 fell significantly in all groups, the fall bein ... | 1986 | 3953227 |
| reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. | the effect of feeding 0.1% hexachlorobenzene (hcb) for 55 days on mortality, body weight, urinary porphyrin excretion, serum thyroid hormones and induction of liver microsomal enzymes was studied in female sprague-dawley rats. this dosage regimen, followed by 42 days of a regular diet, resulted in 33% mortality with a mean time to death of 67 +/- 4 days. body weight of survivors was not affected by dietary hcb, whereas non-survivors underwent a rapid weight loss (wasting) prior to death. at the ... | 1986 | 3952775 |
| thyroid-stimulating hormone pituitary adenomas and hyperthyroidism. | six cases of hyperthyroidism secondary to thyroid-stimulating hormone (tsh)-hypersecreting pituitary adenomas are presented (five females and one male). hyperthyroidism presenting with diffuse goiter was associated with hyperprolactinemia in three cases. elevation of triiodothyronine (t3) and thyroxine (t4) plasma levels was associated with tsh levels ranging between 2 and 2,000 microu/ml. polytomography and computed tomography scanning with coronal views revealed four invasive and two enclosed ... | 1986 | 3952630 |
| endocrine response to acute cold exposure by lactating and non-lactating norway rats. | plasma levels of corticosterone, prolactin and thyroxine (t4) were measured in lactating and non-lactating norway rats at 22 degrees c and 4 degrees c. acute cold exposure increased corticosterone secretion in all groups, although non-lactating female levels rose higher than those of mother rats. while prolactin levels are unaffected by acute cold exposure in non-lactating females, mothers with their litters had lower prolactin levels in the cold. t4 levels increased during cold exposure in lact ... | 1986 | 3952179 |
| [a case of a large thoracic epidural hourglass neurinoma, incidentally detected on routine chest roentgenogram--with respect to the surgical approach]. | in case of the advanced extension into the thoracic cavity, it has been difficult to remove a large thoracic spinal hourglass tumor by conventional laminectomy, even adding costotransversectomy, due to high risk of injuring diverse important vessels and other organs by blind manipulation. a case of a large thoracic spinal hourglass neurinoma with advanced extension into the mediastinum is presented. a 49-year-old female was admitted for the further examination of the left mediastinal tumor, inci ... | 1986 | 3951666 |
| [hydromyelia combined with hydrocephalus]. | a case of hydromyelia (syringomyelia) combined with hydrocephalus is presented. the patient was a 17-year-old-boy. he was a admitted to our hospital because of disturbance of fine movement of the right hand. neurological examinations showed right hemiparesis, right upper muscle atrophy and sensory dissociation of c1-t2 dermatomes. this dissociated sensory impairment gradually deteriorated. ct scan performed 3 and 6 hours after the intrathecal injection of metrizamide revealed an intramedullary s ... | 1986 | 3951665 |
| [iodine burden in premature infants in roentgenologically controlled positioning of central venous silastic catheters]. | 22 sick preterm infants were enrolled in a prospective study of iodine excretion after intravenous injection of a definite amount of the radiopaque dye conray. measurements of tsh and t4 were performed on day 5 and 4 weeks after injection or before dismissal. for comparison iodine excretion was studied in a group of 10 pre-terms without central venous catheters. in most of the babies urinary excretion of iodine was highest on day one with an exponential decline to day three. transient hypothyrox ... | 1986 | 3951444 |
| treatment and outcome of undifferentiated carcinoma of the nasopharynx in childhood: a 13-year experience. | between 1970 and 1983, 22 pediatric patients diagnosed as having undifferentiated nasopharyngeal carcinoma (unc) were treated at the national children's hospital of costa rica; primary tumor with local extension (t3-t4) was present in 45% of the patients, and metastasis of the cervical nodes (n1-n3) in 82%. patients were divided into groups a and b according to the type of treatment received. a description of both groups is as follows. ten patients were treated with 5,000 to 6,000 rads tumor dos ... | 1986 | 3951398 |
| the inner ring (5-) monodeiodination of thyroxine (t4) in cerebral cortex during fetal, neonatal, and adult life. | inner ring (-5) monodeiodination of t4 was studied by incubating t4 (approximately 0.26 mumol/l) with rat cerebral cortical homogenate (approximately 4 mg protein) in the presence of dithiothreitol (up to 400 mmol/l) and quantifying the amount of the product, rt3, by a specific radioimmunoassay. the production of rt3 was dependent on duration of incubation (up to 2 hours), amount of tissue protein (up to 8 mg), temperature (optimal at 37 degrees c) and ph (optimal, 7.0) of the incubation mixture ... | 1986 | 3951360 |
| carcinoma of the tonsillar region. | a retrospective analysis of 171 patients with carcinoma of the tonsillar region is presented. the majority of patients (79%) presented with stage iii and iv disease. three year determinate survival was 81% - t1, 74% - t2, 59% - t3, and 20% - t4. the presence of nodal disease decreased survival by one half. radiotherapy alone was highly successful in controlling early t1 and t2 lesions of the tonsillar fossa. surgery alone or combined radiotherapy and surgery was more successful than radiotherapy ... | 1986 | 3951299 |
| relationship between thyrotropin and thyroxine changes during recovery from severe hypothyroxinemia of critical illness. | in a prospective study of critically ill hypothyroxinemic we assessed the relationship between serum tsh and t4 during the return of serum t4 to normal during recovery. in this longitudinal study of 60 patients with a variety of critical illnesses, including burns, septicemia, and acute renal failure, serum t4 fell to less than 2.7 micrograms/dl (35 nmol/liter) in 24 patients, of whom 14 survived with return of t4 to normal. a rise in total t4 of more than 1.9 microgram/dl (25 nmol/liter) within ... | 1986 | 3949952 |
| calcitonin deficiency in primary hypothyroidism. | the relative lack of sensitivity and specificity of current assays for plasma calcitonin (ct) have made it difficult to study possible ct deficiency conditions. using a new extraction method that considerably improves the sensitivity of the assay for ct monomer, ct levels were measured before and after a short calcium (ca) stimulation test (2 mg ca/kg over 5 min) to determine c-cell secretory reserve in women with autoimmune primary hypothyroidism and normal women. mean basal plasma ct concentra ... | 1986 | 3949951 |
| glucocorticoids and thyroid hormones stimulate biochemical and morphological differentiation of human fetal lung in organ culture. | we characterized the stimulatory effects of both glucocorticoids and thyroid hormones on the surfactant system in human fetal lung. synthesis of phosphatidylcholine (pc) and morphology were examined in explant cultures (15-24 weeks gestation) maintained 1-7 days in serum-free waymouth's medium in a 95%-air-5% co2 atmosphere. control explants (no hormones) had the same rate of choline incorporation into pc between 1 and 7 days, but a significant increase in tissue pc content [82 +/- 21%, (+/- sem ... | 1986 | 3949950 |
| laser cross-linking of nucleic acids to proteins. methodology and first applications to the phage t4 dna replication system. | single-pulse (approximately 8 ns) ultraviolet laser excitation of protein-nucleic acid complexes can result in efficient and rapid covalent cross-linking of proteins to nucleic acids. the reaction produces no nucleic acid-nucleic acid or protein-protein cross-links, and no nucleic acid degradation. the efficiency of cross-linking is dependent on the wavelength of the exciting radiation, on the nucleotide composition of the nucleic acid, and on the total photon flux. the yield of cross-links/lase ... | 1986 | 3949776 |
| a new class of propylthiouracil analogs: comparison of 5'-deiodinase inhibition and antithyroid activity. | after in vivo administration, propylthiouracil (ptu) inhibits not only thyroid iodide uptake and organification, but also t4 5'-deiodinase activity in most peripheral organs. the present report describes the effects of some previously untested 6-substituted 2-thiouracil derivatives on in vivo and in vitro iodide uptake and organification, and on t4 5'-deiodinase activity in liver and pituitary homogenates. when added to homogenates, many analogs were as potent or more potent than ptu in inhibiti ... | 1986 | 3948793 |
| insulin-like growth factor-i action on hypothyroid rat pituitary cells: suppression of triiodothyronine-induced growth hormone secretion and messenger ribonucleic acid levels. | t3 stimulates in vitro gh secretion, whereas somatomedins have been shown to suppress gh. we, therefore, tested the effects of a recombinant human insulin-like growth factor analog (igf-i; thr 59) on t3-induced gh secretion. pituitary monolayer cultures were derived from 4- to 7-week surgically thyroidectomized male rats and grown in hypothyroid medium stripped of t3 and t4. hypothyroid pituitary cell monolayers secreted low levels of gh (200 ng/ml x 72 h). gh secretion was stimulated (185% of t ... | 1986 | 3948790 |
| investigations on iodothyronine deiodinase activity in the maturing rat brain. | 5-monodeiodination of t4 and t3 and 5'-monodeiodination of t4 and rt3 were studied in brain homogenates of male sprague-dawley rats, aged 1-60 days. portions of the homogenates were incubated with the substrates at 37 c for 30 min. the reaction products were estimated by specific rias. all of the four reactions were dependent upon time, temperature, ph, and upon the concentrations of substrate, thiol, and tissue protein. maximal reactions were obtained between 40 and 160 mm dithioerythritol. t4 ... | 1986 | 3948784 |
| biochemical and ontogenic characterization of thyroxine 5'-monodeiodinase in brown adipose tissue from fetal and newborn lambs. | we characterized t4 5'-monodeiodinase (5'-mdi) and its ontogenic changes in brown adipose tissue (bat) of fetal lambs from a gestational age of 99 days to the newborn period. bat 5'-mdi activity in fetal or newborn lamb was markedly enhanced by dithiothreitol (dtt); a near-maximum stimulation was reached at a dtt concentration of 1 mm. the enzyme is heat-labile (inactivated when heated to 56 c for 5 min) and has a ph optimum at 6.5. in the presence of 1 mm dtt, bat 5'-mdi was extremely sensitive ... | 1986 | 3948783 |
| effects of maternal iodine deficiency on the l-thyroxine and 3,5,3'-triiodo-l-thyronine contents of rat embryonic tissues before and after onset of fetal thyroid function. | female rats were placed on a low iodine diet (lid) or lid supplemented with ki. they were mated 3-6 months later. maternal and embryonic tissues were obtained both before the onset of fetal thyroid function, at 11 and 17 days of pregnancy, and at 21 days of gestation. t4 and t3 concentrations were measured by ria. t4 concentrations were very low in the plasma, liver, and lung of lid dams and in all embryonic samples obtained from such mothers, namely 11-day-old embryotrophoblasts, 17-day-old pla ... | 1986 | 3948782 |
| thyroxine entering the thyroid gland via the vascular bed may leave the gland as triiodothyronines. studies with perfused dog thyroid lobes. | in perfused dog thyroid lobes some of the t4 released from thyroglobulin (endogenous t4) is deiodinated during the secretion process to t3 and rt3, leading to a relative hypersecretion of triiodothyronines. the enzymes responsible for this deiodination are found in the follicular cells and resemble the t4 deiodinases in the liver. in the present study we investigated whether exogenous t4 infused into the thyroid via the vascular bed is also deiodinated to t3 and rt3. in two-sided thyroid perfusi ... | 1986 | 3948778 |
| chemiluminescent labeled-antibody assay for thyroxin in serum, with magnetic separation of the solid-phase. | a chemiluminescent labeled-antibody immunoassay has been developed for measurement of total thyroxin (t4) in serum. monoclonal antibodies to t4 labeled with a chemiluminescent acridinium ester are used. serum samples are incubated with the labeled antibodies and a thyroxin-rabbit immunoglobulin conjugate, then reacted with magnetizable particles containing sheep anti-rabbit immunoglobulin. the total reaction time is 40 min. the chemiluminescence intensity of the solid-phase immune complexes is i ... | 1986 | 3948401 |
| radiotherapeutic management of cancer of the supraglottis. | one hundred eighty-five patients with cancer of the supraglottis were treated with curative intent by radiotherapy alone or combined with surgery over a 14-year period. minimum follow-up was 3 years. sixty-eight percent had stage iii or iv disease. moderate-dose radiotherapy, with surgery in reserve, was the policy for the early lesions, and yielded a 3-year locoregional control rate of 76% for t1 n0/n1, t2 n0/n1, and t3 n0/n1 lesions combined. in this group, 84% of patients with locoregional co ... | 1986 | 3948113 |
| spinocerebellar projection fields in the horizontal plane of lobules of the cerebellar anterior lobe in the cat: an anterograde wheat germ agglutinin-horseradish peroxidase study. | using the anterograde transport of wheat germ agglutinin-horseradish peroxidase in the cat, the projection fields of the spinocerebellar tracts were studied in the horizontal plane of lobules of the anterior lobe. the central cervical nucleus projected to 3 longitudinal areas in zone a and the medial part of zone b. the t4-t7 segments projected to two major longitudinal areas in zones a and b, and small areas in zones c1-d. the l2-l4 segments projected densely to longitudinal areas in zone a and ... | 1986 | 3947998 |
| [radioimmunologic system for the quantitative determination of thyroxine in human blood serum]. | a methodological approach to development of a radioimmunological system for quantitative assay of thyroxine (t4) in human blood serum is described. it implies investigation of every component of the system and matching of the components by the physico-chemical properties and concentrations. an antiserum to the t4 conjugate was prepared with bovine serum albumin. the hapten "fitting density" was 30 mol per 1 mol of protein. the antiserum had a titer of 5000, was highly specific and showed affinit ... | 1986 | 3947050 |
| effects of desethylamiodarone on thyroid hormone metabolism in rats: comparison with the effects of amiodarone. | desethylamiodarone is the principal metabolite of amiodarone. amiodarone is a class iii antiarrhythmic agent, which acts by lengthening repolarization in the myocardium, an effect that is identical to that produced by hypothyroidism. amiodarone is known to alter thyroid hormone metabolism, and it has been suggested that the mechanism underlying its antiarrhythmic action is the induction of a myocardial but not generalized hypothyroidism. since the serum levels of desethylamiodarone reach those o ... | 1986 | 3945630 |
| the effects of thyroid hormones on the formation of stress ulcers in the rat. | the low t3 sick syndrome is a syndrome of low triiodothyronine (t3), low to normal thyroxine (t4), and a nonelevated thyrotropin despite the low t3 levels. this syndrome is frequently encountered in critically ill patients. these same patients are also at higher risk to develop acute stress ulcerations. the objective of this study was to access the effects of low circulating thyroid hormone levels on the development of stress ulcers in the rat. rats having had previous surgical thyroidectomies w ... | 1986 | 3945072 |
| transpubic cystectomy and ileocecal bladder replacement after preoperative radiotherapy for bladder cancer. | radical cystectomy was modified by leaving the apical prostatic capsule to facilitate anastomosis of the isolated ileocecal segment to the urethra and to preserve erectile potency. the transpubic approach was used to increase the exposure, and to facilitate dissection and anastomosis. a total of 15 patients with stages t1 to t4 bladder tumors underwent the operation: 13 after preoperative radiotherapy with 4,000 rad and 2 had salvage cystectomy after 6,000 rad. one patient died postoperatively. ... | 1986 | 3944888 |
| iodine kinetic studies during amiodarone treatment. | iodine kinetic studies were performed serially in 15 patients taking 300 mg amiodarone/day for 6 months to assess the biological significance of the high iodine content of the drug. urinary inorganic iodide excretion increased from 0.25 +/- 0.03 (+/- se) mumol/mmol creatinine before treatment to over 7 mumol/mmol during therapy. thyroid iodide clearance fell from 5.93 +/- 0.82 ml/min to less than 0.5 ml/min, while plasma inorganic iodide rose from 0.05 +/- 0.01 mumol/liter to approximately 2.2 m ... | 1986 | 3944239 |
| thyroid function modulates thymic endocrine activity. | the thymus produces humoral factors that induce proliferation and differentiation of t-cells, which are responsible for cell-mediated immunity. recent data in animals suggest that such thymic hormone activity is modulated by the neuroendocrine network and, in particular, by thyroid hormones, but no information is presently available in humans. to study this question, we measured the circulating thymic factor called thymulin (zn-fts) in hyperthyroid and hypothyroid patients. thymulin levels were ... | 1986 | 3944232 |
| twice-a-day radiation therapy for supraglottic carcinoma. | this is a report of a group of 106 patients with supraglottic carcinomas treated by the twice-a-day radiation therapy program at the massachusetts general hospital from october 1979 through april 1984. the program consisted of 1.6 gy per fraction, 2 fractions a day, 5 days a week for a total of 64 gy with 2 weeks rest after the twelfth b.i.d. day. the local control of this group of patients was compared to that of 79 patients treated by the conventional once-a-day program with a daily fraction o ... | 1986 | 3943989 |
| maxillary squamous cell carcinomas staged by computed tomography. | in 72 patients with maxillary squamous cell carcinoma, computed tomography (ct) alone was used for t-staging according to the ajc classification. five, 31, and 36 tumors were diagnosed as t2, t3, t4, respectively. in n0 patients with a minimum follow-up of 2 years, local control rates for t2, t3, and t4 tumors were 33% (1/3), 64% (16/25) and 38% (9/24), respectively. addition of maxillectomy to treatment seemed to have improved the local prognoses in t3 and t4 tumors. high radiation doses of 60 ... | 1986 | 3943982 |
| decrease of circulating level of shbg in postmenopausal obese women as a risk factor in breast cancer: reversible effect of weight loss. | levels of circulating estrone (e1), estradiol (e2), androst-4-ene-3,17-dione (adione), 3,5,3'-triiodothyronine (t3), thyroxine (t4), and sex hormone-binding globulin (shbg) were measured in 10 obese postmenopausal patients with breast cancer and in 10 obese postmenopausal control subjects matched for age, body size, and menopausal status. t3, t4, and shbg were also measured in 10 lean postmenopausal control subjects. in cancer patients after mastectomy, the cytosolic estrogen receptors (e2r) in ... | 1986 | 3943755 |
| effects of vasoactive intestinal peptide on thyroid blood flow and circulating thyroid hormone levels in the rat. | the effects of vasoactive intestinal peptide (vip) on thyroid blood flow and hormone levels were studied in rats. tissue blood flow was determined from the distribution of radioactive microspheres after injection by cardiac puncture directly into the left ventricle of anesthetized rats. initial results indicated that the systemic infusion of 6.25 micrograms vip iv resulted in increased thyroid blood flow, but was also associated with hypotension, as measured by left ventricular pressure. in cont ... | 1986 | 3943485 |
| total and free serum thyroid hormone concentrations in fetal and adult pregnant and nonpregnant guinea pigs. | information on total and free serum thyroid hormone concentrations in the adult and fetal guinea pig (cavia porcellus) is limited. these variables were studied in adult male and female guinea pigs and in pregnant guinea pigs and their fetuses at various times during gestation. total serum t4 levels in adult males, nonpregnant females, and pregnant females did not differ significantly [range, 2.5 +/- 0.3 to 3.2 +/- 0.8 micrograms/dl (mean +/- sd)]. similarly, there were no significant differences ... | 1986 | 3943484 |
| action of hypo- and hyperthyroidism on the postmortal decay of acetylcholine in the rat spinal cord. | the postmortal decay of acetylcholine (ach) was studied in the cervical spinal cords of rats in conditions of hyper- and hypothyroidism. the modifications of thyroid function were achieved either by chronic (20-25 days) administration of l-thyroxine or of methimazole. the basal metabolic rate and plasma t4 concentration were measured to estimate the degree of modification of thyroid activity. the levels of ach at the start of postmortal decay were evaluated by extrapolation to time 0 of the curv ... | 1986 | 3941756 |
| serum thyroglobulin levels are elevated in newborns from iodine-deficient areas. | newborn infants have elevated serum thyroglobulin (tg) levels and reduced iodination of tg. to determine whether a relationship exists between serum tg levels and the degree of tg iodination, 699 newborn infants were studied in 3 areas of sicily: a normal iodine-sufficient (control) area and 2 iodine-deficient areas. in the iodine-sufficient area, the mean cord serum tg level was 25.8 ng/ml (median, 18.0; n = 183). in the iodine-deficient areas, the serum tg levels in newborns were significantly ... | 1986 | 3941162 |
| plasma t4 and t3 levels in naturally metamorphosing eurycea bislineata (amphibia; plethodontidae). | we measured the circulating t4 and t3 levels in the plethodontid salamander eurycea bislineata at various stages of metamorphosis using radioimmunoassay (ria). seven distinct metamorphic stages were defined based on specific developmental events concerning the remodeling and differentiation of skeletal elements. special effort was made to study individual variation in the levels of plasma thyroid hormones. for this reason we did not pool serum from several specimens. the ria was conducted in ali ... | 1986 | 3940927 |
| the thyroid gland of the hawaiian parrotfish and its use as an in vitro model system. | thyroid tissue in the hawaiian parrotfish, scarus dubius, is organized into two discrete lobes, one anterior to the first pair of afferent branchial arteries and the other between the first and second pairs. lobes or pieces of thyroid lobes from s. dubius were incubated in static or perifusion culture using a simple defined medium. in static culture, this thyroid tissue releases thyroxine (t4) responding to bovine thyrotropin (btsh) in a dose-related manner during 4- and 24-hr incubations. at 24 ... | 1986 | 3940924 |
| increased metabolic rate in x-linked hypophosphatemic mice. | hyp mice are a model for human x-linked hypophosphatemia, the most common form of vitamin d-resistant rickets. it has previously been observed that hyp mice have a greater food consumption per gram body weight than do normal mice. this led to the search for some alteration in metabolism in hyp mice. we found that oxygen consumption was significantly higher in hyp mice than in normal c57bl/6j mice and this was accompanied by an increased percentage of cardiac output being delivered to organs of h ... | 1986 | 3940855 |
| thyroid disease in patients with benign and malignant mastopathy. | the incidence of thyroid disease was examined prospectively in 97 consecutive patients with breast cancer (group i) and was compared with that of 61 women with cystic breast disease (group ii) and that of 60 control women (group iii) with no breast problems. thyroid enlargement was found in 47%, 49%, and 22% of those in groups i, ii, and iii, respectively, and treatment with thyroid hormones was taken by 9.3% (i), 8.2% (ii), and 5.0% (iii) of the cases. the mean thyroid-stimulating hormone (tsh) ... | 1986 | 3940612 |
| sarcoid-like lymphocytosis of the lower respiratory tract in patients with active crohn's disease. | to re-evaluate the relationship between crohn's disease and sarcoidosis, we compared the numbers and types of cells recovered by bronchoalveolar lavage from normal volunteers and patients with crohn's disease, with other forms of inflammatory bowel disease, and with sarcoidosis. patients with crohn's disease, but not patients with other inflammatory bowel disorders, had an increase in the number of t lymphocytes on the surface of the lower respiratory tract similar to that seen in patients with ... | 1986 | 3940500 |
| pharmacology of propylthiouracil (ptu) in pregnant hyperthyroid women: correlation of maternal ptu concentrations with cord serum thyroid function tests. | previous studies have characterized the pharmacology of propylthiouracil (ptu) in normal and hyperthyroid subjects, but there is little information available regarding ptu pharmacokinetics in pregnant hyperthyroid women. we investigated the serum ptu response to an oral dose of ptu in six hyperthyroid pregnant women both ante- and postpartum. the serum ptu profile during the third trimester of pregnancy was qualitatively similar to that in nonpregnant subjects, but serum ptu concentrations were ... | 1986 | 3940267 |
| studies on the diurnal pattern of serum 3,5,3'-triiodothyronine. | seventeen subjects, including 12 mildly obese women, were investigated to determine the presence of a diurnal variation in serum t3 levels. a subset of 8 subjects was studied after fasting for 6 days, while another subset of 5 subjects was studied 2 days after receiving 3 mg t4, orally, to suppress tsh secretion. to negate the influence of hemoconcentration produced by ambulation, serum t3 to t4 ratios (nanograms per microgram) rather than total t3 values were used for analysis. a synchronous di ... | 1986 | 3940263 |
| the antidromic activation of tectal neurons by electrical stimuli applied to the caudal medulla oblongata in the toad, bufo bufo l. | in order to specify the tectal projection to the bulbar/spinal regions, the antidromic responses of the physiologically identified tectal neurons as well as the gross antidromic field responses in the optic tectum to electrical stimuli applied to the caudal medulla were examined in the paralyzed common toad, bufo bufo. the antidromic field potential was recorded in the optic tectum in response to electrical stimuli applied to the ventral paramedian portion of the contralateral caudal medulla (wh ... | 1985 | 3939244 |
| human autologous rosette-forming cells. iv. functional role in t-cell activation. | human autorosette-forming cells (auto-rfc), which represent a t4/leu 3a+ cell subset, were investigated for their functional role in t-cell activation. peripheral blood lymphocytes from healthy subjects either remained unfractionated or were separated into recovered or depleted auto-rfc populations. the phytohemagglutinin p stimulation of these three cell suspensions induced normal levels of proliferation, whereas the pokeweed mitogen activation was significantly decreased in the auto-rfc-deplet ... | 1985 | 3939108 |
| a study of lymphocyte populations and subpopulations in hemophiliacs and their relationships with age and consumption of lyophilized factor viii concentrates. | peripheral blood lymphocyte populations and subpopulations of 154 hemophiliacs treated with factor viii concentrates were studied. the patients had significantly increased percentages of leukocytes and lymphocytes and also absolute numbers of the lymphocyte populations in cells/mm3. the increases in cell counts in the two major t cell subpopulations (t4 and t8) were unbalanced, leading to a significant decrease in the t4/t8 ratio. there was no correlation between the t4/t8 ratio and the consumpt ... | 1985 | 3938863 |
| persistent pituitary resistance to thyroid hormone in congenital versus later-onset hypothyroidism. | the pituitary and peripheral responses to l-t4 and l-t3 therapy were studied in 12 patients with congenital goitrous hypothyroidism, in 10 patients with an ectopic thyroid and onset of hypothyroidism at 3-8 years of age, and in 6 patients with adult-onset hypothyroidism, after they had had their chronic thyroid hormone replacement therapy discontinued for 30 days. they were first treated with increasing l-t4 (0.1, 0.2 and 0.4 mg daily) followed by l-t3 (0.05 and 0.2 mg daily) after stopping thyr ... | 1985 | 3938790 |
| further evidence for the presence of thyroxine binding globulin-like protein in human breast adipose tissue. deiodination of thyroxine and triiodothyronine by the microsomal fraction. | the object of the study was to obtain information on how adipose tissue of normal subjects processes thyroid hormones. l-125i-thyroxine(125i-t4) is bound by the cytosol fraction of normal human female breast adipose tissue with high affinity. computer analysis of the binding data revealed the presence of two saturable systems with kd values of 3.9 and 29.1 nm and binding capacities of 1.7 and 8.7 pmol/mg of cytosol protein, respectively; a third binding system was non-saturable. the binding of t ... | 1985 | 3938789 |
| influence of anticonvulsant drugs on thyroid hormones in epileptic children. | thyroid function tests were studied in epileptic children undergoing long-term anticonvulsive therapy with phenytoin, primidone or mephenytoin. serum t4 was decreased in all three treated groups, serum t3 was diminished only in those treated with phenytoin or primidone. ft4 was also significantly decreased while serum tsh and tbg were not affected in the treated patients. the effect of anticonvulsant drugs on thyroid hormone catabolism and peripheral conversion of t4 seems to be important in the ... | 1985 | 3938291 |
| the effect of maneb, zineb, and ethylenethiourea on the humoral activity of the pituitary-thyroid axis in rat. | ethylenebisdithiocarbamates (ebdcs) maneb and zineb are widely used fungicides the final metabolite of which is ethylenethiourea (etu). ebdcs distort the humoral activity of the thyroid gland, and etu is especially active in this respect. male wistar rats were exposed either to exogenous (100 ng i.p.) or endogenous (+4 degrees c) trh stimulation. etu (100-500 mg/kg i.p.) caused no changes in serum tsh levels whereas zineb (70-500 mg/kg i.p.) significantly decreased the bursts induced by cold or ... | 1985 | 3938269 |
| [contribution of amino acid deficiency to primary hypothyroidism associated with protein-calorie malnutrition]. | a 68-year-old male patient without any previous thyroidal disease developed three times of transient primary hypothyroidism associated with protein-calorie malnutrition (pcm). because of his diabetes mellitus, alcoholic hepatitis, chronic pancreatitis and blind loop syndrome, his nutritional balance was easily disturbed leading to pcm. although he recurrently developed primary hypothyroidism associated with pcm, this condition was completely restored by protein-calorie repletion. the possibility ... | 1985 | 3937744 |
| neomycin is more efficient than streptomycin in suppressing frameshift mutations. | the effects of streptomycin and neomycin on the phenotypic suppression of frameshift mutations in the lacz gene of escherichia coli and on the efficiency of suppression of amber mutations in t4 phage by the informational supe trna nonsense suppressor were compared. neomycin stimulated much more efficiently than streptomycin the phenotypic suppression of frameshift mutations. because neomycin favors mismatches of the central codon base whereas streptomycin favors mismatches of the first codon bas ... | 1985 | 3937597 |
| t cell differentiation antigens expressed by peripheral blood lymphocytes in crohn's disease. | the aim of the present study was to investigate whether an imbalance of peripheral blood immunoregulatory t cells is a feature of crohn's disease. the cluster of differentiation antigens 3,4 and 8 were investigated and the relative prevalence of pbl expressing each antigen was defined using a panel of three monoclonal antibodies (okt3, otk4 and okt8). a significant decrease in the okt3 and okt4 positive cells was found in cd patients as compared with healthy controls. no significant difference w ... | 1985 | 3937546 |
| [prognostic factors and results of external irradiation of cancers of the base of the tongue]. | at the curie institute, between 1958-1980, 166 patients were treated for squamous cell carcinoma of the base of the tongue, by external radiotherapy alone. the absolute survival was 45%, 39%, 26% at 2, 3, 5 years. 95% local and loco-regional failures arrived within the first two years; the nodal failures isolated were rare (4%). unfavorable prognosis features are: the size of the tumor and the clinical radiation-induced regression of the primary. a new therapeutic approach is discussed: an addit ... | 1985 | 3937474 |
| [effect of ethinyl estradiol sulfonate/norethisterone acetate on tsh, t4, tbc and the ft4 index in pubertal girls]. | in 13 healthy tall girls the influence of the hormonal treatment with depotestrogen ethinylestradiolsulfonate and norethisterone acetate on basal and trh stimulated tsh secretion, total thyroxine (t4), thyroxine binding capacity (tbc) and free thyroxine index (ft4 index) was investigated. the investigations were performed before treatment, during the 8th to 11th cycles of treatment, and in the 4th month after finishing the therapy. tsh and t4 serum levels were determined by ria, tbc by radio age ... | 1985 | 3937373 |
| [concentrations of thyroxine, beta carotene, vitamin a and pregnancy in heifers after administration of beta carotene]. | serum concentrations of thyroxine (t4), beta-carotene (beta k), vitamin a and conception after the first insemination on the zero, sixth and 21st day were studied in 63 heifers fed synthetic beta k supplement in groups i to iv at stanchion housing and low-carotene diet. the following amount of beta k was supplemented per head/day: i--0 mg (control, n = 17), ii--100 mg (n = 16), iii--200 mg (n = 14) and iv--400 mg (n = 16). the parameters were evaluated separately according to groups and concepti ... | 1985 | 3937314 |
| [function of the hypothalamo-hypophyseal-thyroid system in juvenile enlargement of the thyroid]. | a study of tth, t3 and t4 content in the blood serum of adolescents with juvenile thyroid enlargement showed changes which were typical of subclinical hypothyrosis. a conclusion is made about the necessity of a follow-up of children with juvenile thyroid enlargement and administration of pathogenetic therapy with thyroid hormonal drugs. | 1985 | 3937155 |
| [the thyroid hormone system in mucoviscidosis]. | endocrine disorders do not represent primary manifestations in children with cystic fibrosis. abnormal thyroid gland function is commonly observed in patients with chronic nonthyroidal illnesses. serum concentrations of tsh, t4 and t3 were measured and a trh-stimulation test (200 micrograms relefact per kg body weight) was performed in 24 patients with cf 6 to 16 1/2 years of age. as compared to the controls, cf patients had increased basal tsh and lower t4 and t3 concentrations. finally they ex ... | 1985 | 3936972 |
| amniotic fluid thyrotropin (tsh) following maternal administration of thyrotropin releasing hormone. | cord blood and amniotic fluid thyrotropin (tsh), t4, t3, and rt3 concentrations were measured in 49 women who received 400 micrograms thyrotropin releasing hormone (trh) iv during labor and in 16 control women who received saline. cord blood serum tsh concentrations were elevated for as long as 4 hours after trh administration and peak values (38.0 +/- 4.2 microu/ml) were observed from 61-120 minutes after tsh as compared to control values of 5.0 +/- 0.3 microu/ml. the elevations in fetal tsh co ... | 1985 | 3936914 |
| assessment of pentachlorophenol toxicity in newborn calves: clinicopathology and tissue residues. | newborn holstein bull calves were fed either analytical pentachlorophenol (apcp) or technical pentachlorophenol (tpcp) for 6 wk to establish and compare the clinical and pathologic manifestations of toxicity. four groups of three calves/group were each fed either 1 or 10 mg x (kg body weight)-1 x d-1 of either apcp or tpcp. a fifth group served as control. dosages of both pcp preparations were normalized to contain equal concentrations of pcp. toxic effects were observed only at the 10 mg/kg dos ... | 1985 | 3936833 |
| relationship between serum free thyroxine, total thyroxine and thyroxine-binding globulin concentrations in patients with graves' disease. | statistical analysis of relationship between free thyroxine (ft4) and thyroxine (t4) in patients with graves' disease has revealed that serum ft4 values correlated well with serum t4 values at variable thyroid states before and during treatment with anti-thyroid drugs. however, the ratio of ft4 concentration to t4 concentration at hyperthyroid state was more than twice as large as the ratio at euthyroid and hypothyroid states. these findings are considered to denote the elevation of per cent of ... | 1985 | 3936763 |
| [partial abolition of seasonal variations of testicular weight in rams by decreasing the photoperiod]. | under moderate latitudes all breeds of rams undergo seasonal variations in testicular weight with a maximum during summer under decreasing daylength ([1]-[4]). similarly, in rams submitted to a 6-month artificial light regime [5] or to an alternation of long (16l:8d) and short (8l:16d) days [6] an increase in testicular weight occurred following a decrease in daylength and vice versa. however this effect is transitory, a phenomenon which can be referred as photorefractoriness. in the present stu ... | 1985 | 3936602 |
| reevaluation of thyroid function in low birth weight infants based on free triiodothyronine and triiodothyronine. | we attempted to analyze the physiological meaning of abnormally low thyroid hormones in low birth weight (lbw) infants on the basis of cross-sectional data on free triiodothyronine (free t3) and t3 in addition to the other thyroid hormones. in lbw infants, the levels of free t3 and t3 were lower than those of normal infants, similar to the relation between free thyroxine (free t4) and t4. the ratio of free t3/t3 or free t4/t4, however, was not different between the groups. the levels of thyroid- ... | 1985 | 3936550 |
| thyroid hormones in the human pregnancy. | radio-immunologic t3, t4, ft3, ft4, rt3, tbg and 17 beta-estradiol were measured in women in the 2nd and 3rd trimester of pregnancy, during labor, and during the first 14 days of the puerperium. a group of women suffering with gestosis eph were also investigated. our data suggest that in women suffering with gestosis eph and during labor in normal pregnancy there is a t3-selective defect (low t3 syndrome) in which the conversion route of t4 into t3 is inhibited while the conversion route of t4 i ... | 1985 | 3936332 |
| modulation of red cell metabolism by states of decreased activation: comparison between states. | marked decline of red cell metabolism has been described during the acute state of decreased activation associated with the stylized mental technique of transcendental meditation (tm) in long-term meditators (5-10 years regular elicitation, tm instructors). it is not known whether unstylized rest is accompanied by a similar effect and it is not known what effector(s) may contribute to red cell metabolic changes in these states. in the present study ordinary, unstylized rest was found to be accom ... | 1985 | 3936073 |
| heteroantibody duplexes target cells for lysis by cytotoxic t lymphocytes. | antibodies to the clonally unique variable-region determinants (idiotype) of the antigen-specific alpha beta heterodimeric receptor of a clone of cytotoxic t cells (ctls) were shown previously to render diverse cells, regardless of their own surface antigens, susceptible to lysis by that clone of ctls. to extend these findings, we have sought to develop a general means for targeting cells for destruction by any ctl, without regard to its alpha beta idiotype and specificity for antigen. we explor ... | 1985 | 3936039 |
| [prealbumin and retinol-binding protein]. | thyroxin binding prealbumin (tbpa) and retinol binding protein (rbp) are associated in a complex responsible for the transport of vitamin a and of about 10% of the thyroid hormones t3 and t4. both are synthetized in the liver. rbp can be characterized by two essential points: its hepatic secretion depending on the nutritional vitamin a status explains the close relation noted between these two parameters; its catabolism located in the renal tubular cells indicates the important role played by ki ... | 1985 | 3936007 |
| thyroid hormone induces metamorphosis of flounder larvae. | the role of thyroid hormone in flounder metamorphosis was studied by use of thyroxine and the antithyroidal agent, thiourea (tu). t4 stimulated metamorphosis of pelagic larvae, producing miniatures of naturally metamorphosed benthic juveniles. in contrast, tu induced metamorphic stasis, resulting in giant pelagic larvae. these results indicate that the thyroid plays a role in flounder metamorphosis comparable to its well-known developmental role in amphibian metamorphosis. | 1985 | 3935513 |
| thyroglobulin and thyroid hormones in patients on long-term treatment with phenytoin, carbamazepine, and valproic acid. | serum concentrations of total triiodothyronine (t3) and thyroxine (t4) as well as serum thyroid-stimulating hormone (tsh) and thyroglobulin (tg) were measured in 24 patients with epilepsy taking anticonvulsants (either phenytoin, carbamazepine, or valproic acid as single treatment) and in a control group of 28 patients with scoliosis but without thyroid disease. the t4 as well as the tsh concentrations were depressed in patients on phenytoin or carbamazepine treatment. the t3 concentration was i ... | 1985 | 3935423 |
| hypothalamic pituitary function testing on children receiving carbamazepine or sodium valproate. | an investigation of hypothalamic pituitary axis (hpa) function was performed on children and adolescents receiving long-term monotherapy with either carbamazepine (cbz) or sodium valproate (nav). there was a significant reduction in total t4 in the cbz group. free t4, t3, and thyroid-stimulating hormone response to thyrotropin-releasing hormone were similar in both groups. all patients produced an adequate growth hormone response to either arginine or l-dopa. basal cortisol levels were similar i ... | 1985 | 3935421 |
| hyperthyroidism caused by a pituitary thyrotrophin-secreting tumour with excessive secretion of thyrotrophin-releasing hormone and subsequently followed by graves' disease in a middle-aged woman. | a 46-year-old woman had signs of thyrotoxicosis and galactorrhoea. serum immunoreactive tsh and its alpha-subunit increased in the presence of high serum triiodothyronine (t3), thyroxine (t4), and free t4 concentrations, whereas beta-subunit tsh was undetectable. exogenous trh failed to increase serum tsh. serum tsh was markedly suppressed by glucocorticoid, but was increased by antithyroid drug. l-dopa or bromocriptine partially suppressed, but nomifensine had no influence on serum tsh. serum p ... | 1985 | 3934894 |
| [age and thyroid function (radioimmunologic study)]. | radio-immunologic study on the hormones of hypopheseal-thyroid axis was performed in 207 healthy subjects, aged from 0 to 79, namely: thyroxine (t4), triiodothyronine(t3) revrese t3 (rt3), thyrotropic hormone (tth), thyroxine-binding globulin (tbg) and the index of free thyroxine was calculated (ift4). considerably elevated levels of thyroid indices were established at birth and only rt3 and tth were normalized during the early neonatal period. the thyroid indices were also kept higher during th ... | 1985 | 3934847 |
| proliferating cells in the synovial fluid in rheumatic disease. an analysis with autoradiography-immunoperoxidase double staining. | the subtype of the proliferating cells in the synovial fluid of patients with rheumatoid arthritis (ra), ankylopoietic spondylarthrosis (spa), and osteoarthritis (oa) was studied with autoradiography-immunoperoxidase double staining. of all spontaneously proliferating synovial fluid cells in chronic arthritis, 59 +/- 4% displayed t8 differentiation marker, whereas t4 (21 +/- 4%) and b (2 +/- 1%) cells were few. of all t4+ and all t8+ lymphocytes, 0.55 +/- 0.1% and 0.90 +/- 0.1%, respectively, in ... | 1985 | 3934748 |
| supplemental thyroid hormones and hatchability of turkey eggs. | fertile turkey eggs were injected with thyroid hormones to test the effects of exogenous hormones on hatchability. physiological doses of thyroxine (t4) and triiodothyronine (t3) of 50 and 25 ng, respectively, injected at setting, depressed hatchability. conversely, injections of t4 and t3 at 25 days of incubation significantly (p less than .05) improved hatchability. injections with thyroid-stimulating hormone (tsh) or tyrosine had no significant effect on hatchability when injected at setting ... | 1985 | 3934657 |
| patients at risk for aids-related opportunistic infections. clinical manifestations and impaired gamma interferon production. | we studied 81 men (79 homosexuals and 2 drug abusers) with persistent lymphadenopathy to determine whether those at risk for aids-related opportunistic infections could be identified prospectively. (sixty-nine of 76 [91 per cent] had antibodies to human t-cell lymphotropic virus type iii [htlv-iii], and 76 of 79 [96 per cent] had abnormal t4/t8 cell ratios.) during the follow-up period (mean +/- s.e.m., 12.9 +/- 0.5 months; range, 8 to 19), infections developed in none of 38 patients with lympha ... | 1985 | 3934537 |
| natural anti-bacterial activity against salmonella typhi by human t4+ lymphocytes armed with iga antibodies. | peripheral blood mononuclear cells from normal volunteers possess natural anti-bacterial (na) activity against s. typhi that can be measured in a 2-hr in vitro assay. employing fractionation on nylon wool columns, percoll gradients, plastic adherence, and e rosetting, the effector cell of na activity appeared to be a lymphocyte of the t lineage rather than a macrophage, a b lymphocyte, or a large granular cell. moreover, complement-dependent killing with monoclonal antibodies such as okm1, okb7, ... | 1985 | 3934277 |
| antigen presentation by interferon-gamma-treated endothelial cells and fibroblasts: differential ability to function as antigen-presenting cells despite comparable ia expression. | the effect of interferon-gamma (ifn-gamma) on endothelial cell (ec) and fibroblast (fb) class ii major histocompatibility complex (mhc) gene product expression and antigen presenting ability was examined. control fb did not express class ii mhc gene products, whereas a small (less than 1%) population of passaged ec expressed class ii gene products. ifn-gamma induced a comparable density of hla-dr expression on nearly all ec and fb. ifn-gamma-treated ec and fb also expressed hla-dp but at a lower ... | 1985 | 3934267 |
| interpreting thyroid tests in the elderly: updated guidelines. | t4 determinations by themselves have been reported to be cost-effective as a screening test to identify patients with unsuspected thyroid disease. the most consistent finding in healthy older subjects, that of a decrease in circulating t3, means that reference intervals for t3 need to be adjusted downward by as much as 25%. | 1985 | 3934049 |
| the relative potencies of l-t4 and l-t3 on the pituitary-thyroid axis in the japanese quail. | we have studied indirectly the relative contribution of the two thyroid hormones t4 and t3 to the feedback regulation of thyrotropin (tsh) secretion in quails, by means of the trh-test. adult euthyroid quails received a single injection of thyrotropin-releasing hormone (trh) (1 or 10 micrograms/100 g body wt) and were killed different times after. peak level of t4 occurred at 40 min and further served as the trh-test response. the administration of two different doses of t4 or t3 (0.5 or 2 micro ... | 1985 | 3934029 |
| the effect of exposure to 40 degrees on the heat production and the serum concentrations of triiodothyronine, thyroxine, and corticosterone in immature domestic fowl. | four-week-old fowl were exposed to 40 degrees for 35 days and the effects on the serum concentrations of triiodothyronine (t3), thyroxine (t4), and corticosterone were investigated. changes in resting heat production, food intake, body temperature, body weight gain, and growth (both in terms of skeletal growth and weight of selected organs) were also measured. body temperature was increased at 40 degrees, and body weight gain and skeletal growth were both reduced. the serum concentrations of t3 ... | 1985 | 3934027 |
| food intake regulation of circulating thyroid hormones in domestic fowl. | the relationship between food intake and thyroid function has been investigated in immature domestic fowl. starvation delayed, but did not suppress, the triiodothyronine (t3) response to intravenously administered thyrotropin-releasing hormone (10 micrograms/kg). this probably resulted from a suppression of monodeiodinase activity, since the conversion of thyroxine (t4) to t3 in thyroidectomised birds following an intramuscular injection of t4 (10 micrograms/kg) was markedly reduced by starvatio ... | 1985 | 3934026 |
| effects of melatonin and thyroxine replacement on thyrotropin, luteinizing hormone, and prolactin in male hypothyroid hamsters. | the effects of daily evening melatonin injections on plasma and pituitary levels of tsh, lh, and prl in hypothyroid hamsters maintained under a 14-h light, 10-h dark photoperiod were investigated. circulating levels of thyroid hormones were monitored, and testicular weights were recorded. thiourea-induced increases in serum and pituitary tsh were significantly reduced by melatonin injections. control hamsters, not receiving thiourea, responded to daily evening melatonin injections with a decreas ... | 1985 | 3933963 |
| diagnosis of hyperthyroidism: the newer biochemical tests. | investigation of suspected hyperthyroidism is conventionally based on measurement of total or free t4 as the initial test, followed in equivocal cases by total or free t3, and the trh test. recent developments in techniques for measuring free hormones and tsh promise to change this approach. free t4 and free t3 can now be rapidly and simply quantitated in whole serum using labelled analogue radioimmunoassays. specific and highly sensitive assays using labelled monoclonal antibodies are now avail ... | 1985 | 3933863 |
| free thyroid hormone levels and tsh response to trh in patients with autonomous thyroid adenomata and normal t3 and t4. | free thyroid hormone levels together with basal and trh stimulated tsh levels, have been determined in 50 patients with autonomous thyroid adenomata, who had normal serum total t3 and t4 values. similar measurements were made in 33 healthy subjects. ft3 and ft4 plasma levels were significantly higher (p less than 0.01 and p less than 0.05 respectively), and basal and trh stimulated tsh were significantly lower (p less than 0.05 and p less than 0.001 respectively) in the patients than in the cont ... | 1985 | 3933862 |
| t-cell phenotypic profile and colony formation during recovery from cytotoxic therapy-induced marrow aplasia. | lymphocytes which appeared in the peripheral blood early (approximately 4 weeks) after complete bone marrow aplasia were studied in two groups of patients. twenty-two allogeneic bone marrow transplant recipients and 12 acute nonlymphocytic leukemia patients (entering remission) were compared to 70 healthy control subjects studied during the same time interval. studies performed included phenotyping t-cells using monoclonal antibodies and t-cell colony formation in response to phytohemagglutinin. ... | 1985 | 3933827 |
| influence of hormones and undernutrition on brain development in newborn rats. | high l-thyroxine (t4) and cortisol doses given to rats during the first 8 days of life and on the first day only respectively, produce decrease of body and brain weight and perturbances to brain energy substrates, i.e. glucose and ketone bodies. the same alterations are found in the undernourished rats from the prenatal period. the pituitary gh and tsh is decreased in the t4- and cortisol-injected animals. the plasma acth is decreased in the treated cortisol animals at 8, 12 and 22 days of life. ... | 1985 | 3933579 |
| iridium-192 implants in the treatment of tonsillar region malignancies. | a total of 127 patients with histologically proved diagnosis of carcinoma of the tonsillar region and soft palate were treated over the past ten years utilizing interstitial iridium-192 implants. eighty patients were treated for primary tumors and 47 patients for either recurrent or persistent tumors after definitive irradiation and/or surgery. all patients with primary tumors were treated by a combination of external megavoltage irradiation and interstitial iridium-192 implants, whereas patient ... | 1985 | 3933464 |
| the influence of age and sex on tests of thyroid function. | serum concentrations of total thyroid hormones, thyroid hormone binding proteins, free thyroid hormones and thyroid stimulating hormone (tsh) were measured in a large group of healthy normal subjects (n = 218) to determine the influence of age and sex on tests of thyroid function. no effect of age on measurements of total thyroxine (t4), total triiodothyronine (t3) or reverse t3 was evident. concentrations of free t4, free t3 and tsh were similarly unaffected, suggesting that increasing age alon ... | 1985 | 3933400 |
| t-cell subpopulations in patients with monoclonal gammopathies: essential monoclonal gammopathy, multiple myeloma, and waldenstrom macroglobulinemia. | t-cell subsets defined by monoclonal antibodies (okt3, okt4, and okt8) were analyzed in 117 patients with monoclonal gammopathies--69 multiple myeloma (mm) (30 untreated and 39 treated), 14 waldenström's macroglobulinaemia (wm), and 34 essential monoclonal gammopathy (emg) patients. the percentage and absolute numbers of total t-lymphocytes (e+, okt3+ cells) were within the normal range in all groups except for the treated mm patients, in which a decrease in the absolute number could be observed ... | 1985 | 3933332 |
| post-operative analgesia by epidural versus intramuscular nicomorphine after thoracotomy. part ii. | one hundred and sixty-three patients subjected to three different types of thoracic operation were allocated randomly either to balanced intravenous anaesthesia including i.v. opiates with post-operative intramuscular opiates (intramuscular group) or to balanced intravenous anaesthesia without i.v. opiates but with high thoracic epidural regional block during the operation as well as epidural nicomorphine post-operatively (epidural group). post-operative nicomorphine in either group was given on ... | 1985 | 3933262 |
| effect of thyroid hormones on liver microsomal enzyme induction in rats exposed to 2,3,7,8,-tetrachlorodibenzo-p-dioxin. | the effect of thyroidectomy and thyroid hormone replacement therapy on liver microsomal enzyme induction was studied in 2,3,7,8,-tetrachlorodibenzo-p-dioxin (tcdd)-treated rats (100 micrograms/kg). treatment of non-thyroidectomized rats with tcdd had no effect on the concentration of liver microsomal cytochrome b5. in contrast, cytochrome b5 content was increased by tcdd treatment of thyroidectomized rats, regardless of replacement therapy with either t3 or t4. tcdd treatment increased the conce ... | 1985 | 3933144 |
| hyperthyroidism in elderly women. registered and detected by screening in a primary health care district. | a laboratory screening for thyroid disease was performed among women older than 60 years in a primary health care district in a goiter region. the screening was combined with a questionnaire regarding previously treated thyroid disorder. a total of 1442 women i.e., 97.3% of the population studied were investigated. through the laboratory screening we found 28 women (1.9%) with hyperthyroidism and they were successfully treated. through the questionnaire 50 women (3.4%) were identified with previ ... | 1985 | 3933071 |
| alterations in circulating thyroid hormones and thyrotropin in euthyroid patients with graves' disease after total thyroidectomy: comparison between responders and nonresponders to tsh-releasing hormone. | eleven euthyroid patients with severe exophthalmos of graves' disease who had been treated with antithyroidal drugs for one to three years prior to total thyroidectomy were studied. all patients were clinically and biochemically euthyroid at the time of operation. according to their responses of tsh to trh prior to operation, the patients were divided into two groups: (1) five responders and (2) six nonresponders. in group 1, serum tsh levels increased significantly on the third day after thyroi ... | 1985 | 3932818 |