Publications

the infected pacemaker pocket.	between january, 1963, and september, 1978, a total of 1,789 pacemakers were implanted at henry ford hospital. infection at the site of implantation developed in 19 instances for an incidence of 1.06 percent. the most common organism cultured was staphylococcus epidermidis, and conservative treatment was successful with these patients. in all patients with organisms other than staphylococcus epidermidis, reimplantation of a new unit in a new, clean site was required.	1979	379440
[morphological studies on antibacterial activities of cefotiam (author's transl)].	1. cefotiam was demonstrated to be more potent than cefazolin in its antibacterial activities against clinical isolates of e. coli, klebsiella, serratia, proteus mirabilis, proteus morganii and proteus inconstans. mics of cefotiam with 10(6) cells/ml inoculum size were considerably lower than those with 10(8) cells/ml. 2. organisms lysed when exposed to cefotiam at concentrations higher than the mics with 10(8) cells/ml. morphological changes of organisms into filament occurred even at concentra ...	1979	379387
acquisition of klebsiella aerogenes by neonates.	the acquisition of klebsiella aerogenes by neonates born in hospital has been studied by sero- and klebecin typing. this organism was more commonly carried in the bowel of breast-fed babies than of bottle-fed babies. only very rarely did babies acquire strains of k. aerogenes from their mothers. k. aerogenes was widely distributed in the ward environment and on the hands of nurses and mothers. some strains were able to spread on the ward. these results are relevant to the control of k. aerogenes ...	1979	379340
enterotoxigenic enteric bacteria in foods and outbreaks of food-borne diseases in sweden.	all of 86 food routinely examined for potentially pathogenic enteric bacteria were found to harbour one or more coliform species. none of the strains isolated produced heat-labile enterotoxin (lt) or showed invasive properties. the suckling mouse test indicated that one strain of escherichia coli produced heat-stable enterotoxin (st). twelve incidents of suspected food poisoning were also investigated. in two of them the foods examined contained lt-producing strains of e. coli and in two there w ...	1979	379211
mastitis: i. in vitro antimicrobial activity of alkyl amines against mastitic bacteria.	the activities of branched and straight chain amines (10 to 18 carbons chain length) were compared in inhibiting the growth of five microorganisms that cause about 95% of bovine mastitis. three gram-positive (streptococcus agalactiae, streptococcus uberis, staphylococcus aureus) and two gram-negative (escherichia coli, klebsiella pneumoniae) bacteria were used in a trypticase soy broth tube culture growth assay. sixty-two compounds were screened at concentrations of 200, 100, 50, 25, 10, 5, and ...	1979	379061
coliform mastitis--a review.		1979	379056
introduction of bacteriophage lambda into cells of klebsiella aerogenes.	we have shown that a mutation in the cro gene of phage lambda greatly reduces zygotic induction. this observation has allowed us to move this phage on an episome into cells of klebsiella aerogenes where it grows as well as in cells of escherichia coli. this technique should allow the introduction of various derivatives of lambda into any organism which is able to receive deoxyribonucleic acid from e. coli.	1979	378984
fermentation of 1,2-propanediol with 1,2-ethanediol by some genera of enterobacteriaceae, involving coenzyme b12-dependent diol dehydratase.	klebsiella pneumoniae (aerobacter aerogenes) atcc 8724 was able to grow anaerobically on 1,2-propanediol and 1,2-ethanediol as carbon and energy sources. whole cells of the bacterium grown anaerobically on 1,2-propanediol or on glycerol catalyzed conversion of 1,2-diols and aldehydes to the corresponding acids and alcohols. glucose-grown cells also converted aldehydes, but not 1,2-diols, to acids and alcohols. the presence of activities of coenzyme b(12)-dependent diol dehydratase, alcohol dehyd ...	1979	378959
order of genes near nif in klebsiella pneumoniae.	analysis of strains with deletions of all or part of nif have ordered the klebsiella pneumoniae genetic loci as thi rbt dal udk gnd rfb has nif shia. the his-nif plasmids prd1 and ptm4010 contain the genes gnd rfb his nif shia.	1979	378930
capsular serotypic specificity of the protection conferred on mice by klebsiella pneumoniae ribosomal preparations.	klebsiella pneumoniae ribosomal preparations protect mice immunized by the subcutaneous route against an intraperitoneal challenge of 100 50% lethal doses. the minimal protective doses are 5 and 0.4 micrograms of proteins for preparations extracted from strains of capsular serotypes 1 and 2, respectively. this difference in protective activity is also found in bacteria killed by formalin. the protective activity of these preparations is not diminished by their purification on sucrose gradient, w ...	1979	378855
the possible role of catabolic plasmids in bacterial steroid degradation.		1979	378710
respiratory nitrate reductase: its localization in the cytoplasmic membrane of klebsiella aerogenes and bacillus licheniformis.	the sidedness of the respiratory nitrate reductase in the cytoplasmic membrane of bacillus licheniformis and klebsiella aerogenes was studied by indirect immunofluorescence and by lactoperoxidase-catalyzed iodination. it was shown that the two subunits (mr 150000 and 57000, respectively) of nitrate reductase of b. licheniformis are localized on the cytoplasmic side of the membrane, whereas the k. aerogenes enzyme is a transmembrane protein. the different localization of nitrate reductase in the ...	1979	378657
characterization of motile and acetoin-negative klebsiella pneumoniae strains by dna: dna by hybridization.	hybridization studies were carried out to determine the extent of divergence between different members of the enterobacteriaceae and group d, previously described by numerical analysis of phenotypic characters, and comprising strains isolated from surface waters. this group, apparently belonging in or related to the genus citrobacter on the basis of the imvic tests differs from this taxon by numerical analysis and dna base composition. our work reveals a dna relatedness of 81-89% between the cen ...	1978	378119
the impact of hospitalization on the aerobic fecal microflora.	quantitative bacteriological analysis of the aerobic fecal microflora of 75 patients indicated that, at the time of admission to hospital, escherichia coli were the predominant fecal aerotolerant bacteria. subsequent fecal samples showed a progressive supplantation of e coli by klebsiella, enterobacter and proteus. at the end of 21 days of hospitalization, e coli remained predominant in only 30 patients. none of the patients had received antibiotics, undergone surgery or been subjected to x-ray ...	1979	377964
[antibacterial effect of ankerplast spray].	the diffusion test yielded no satisfactory results. in the tube test, both the spray and the solvent (in a dilution of 1:4 and 1:8, respectively) proved to be bacteriostatically active against enterococci, staphylococcus aureus, escheria coli, proteus, and pseudomonas aeruginosa. these germs were killed within 30 minutes in the test for bactericidal activity, whereas the reference substance (1% phenol) required 1--2 hours, except against the last-named germ. even the copolymer exerted a bacteric ...	1979	377580
a comparison of the antibacterial activity of sulphonamide-trimethoprim combinations.	sensitivity patterns of 326 clinical isolates toward sulphonamide/trimethoprim combinations were tested in vitro. the relative merits of the different combinations are discussed in their pharmacological and bacteriological contexts. it is concluded that organisms sensitive to cotrimoxazole as judged by in vitro sensitivity tests performed at 37 degrees c are also sensitive to sulphamoxole/trimethoprim.	1979	377523
plasmids and transposons and their stability and mutability in bacteria isolated during an outbreak of hospital infection.		1979	377321
nursing care study. patient on a ventilator: beyond the speech barrier.		1979	377248
detection of neonatal bacteremia.		1979	376806
septicemia in association with acute lymphoblastic leukemia.	fifty consecutive episodes of septicemia were studied in 41 children who had acute lymphoblastic leukemia. seventy-six percent of these episodes occurred when the absolute granulocyte count was 200/mm3 or less and were caused by gram-negative enteric and gram-positive mucocutaneous bacteria. in eight patients, streptococcus pyogenes was isolated at the time when all was diagnosed. multiple anaerobic and aerobic isolates from a single blood culture were associated with abdominal distress, whereas ...	1979	376800
an investigation into the incidence and sources of klebsiella infections in hospital patients.	coliforms isolated from infections over a period of 22 months were examined and 16% were shown to be klebsiellas. the biochemical reactions and serotypes of these klebsiellas were determined and the relationship between species, serotype and type of infection investigated. although no obvious outbreaks of infection occurred during this period a number of clusters of isolations of the same serotype of klebsiella were found. using an enrichment method for the isolation of klebsiellas from faeces, ...	1979	376698
nosocomial klebsiella pneumoniae epidemic in a neonatal special care unit.		1978	376441
coenzyme b12-dependent diol dehydrase: purification, subunit heterogeneity, and reversible association.		1979	375836
[structure of the microflora of suppurative wounds and its sensitivity to antibiotics].	clinico-bacteriological examination of patients with purulent infections showed that staphylococcus was the predominating microflora in the wounds. simultaneously an increasing role of gram-negative conditionally pathogenic bacteria was shown. multiple drug resistance was found in the organisms tested. the highest sensitivity levels were observed to gentamicin, kanamycin, tetracycline, levomycetin. it was shown by means of special typing methods that staphylococci of phage group iii and ps. aeru ...	1979	375824
enteric gram-negative rods, 1976.		1979	375729
gram-negative bacillary sepsis associated with use of lipid emulsion in parenteral nutrition.		1979	375720
[multiple drug resistance in different medical institutions: frequency and resistance patterns in escherichia coli, proteus mirabilis and klebsiella spec (author's transl)].		1979	375625
[probability of resistance to 10 standard- and 7 recently introduced antimicrobics in multiresistant strains of escherichia coli, proteus mirabilis and klebsiella spec (author's transl)].		1979	375624
bacteriophage specificity in the identification of yersinia pestis as compared with other enterobacteria.	bacteriophage typing of yersinia pestis and the specificity of the phage among enterobacteriaceae were investigated. the bacteriophage used for rapid identification of y. pestis reacted with representative strains of all recognized species of shigella as well as with salmonella cholerae-suis. reactive shigella serotypes were sh. dysenteriae 1 and 9, sh. flexneri 2a, sh. boydii 1 and 6, and sh. sonnei. patterns consisting of isolated plaques (two cases) or absence of plaques were observed when th ...	1978	375327
the mutagenic action of nitroimidazoles. iv. a comparison of the mutagenic action of several nitroimidazoles and some imidazoles.	the mutagenic action of 51 imidazoles was investigated. the fluctuation test of luria and delbrück was used, with klebsiella pneumoniae as test organism. 8 compounds, including 5 with a weak mutagenic action in the fluctuation test, were also investigated by the ames test in which salmonella typhimurium ta100 was used. of the 51 imidazoles examined, 33 were nitroimidazoles. 31 of the latter appeared to be mutagenic, whereas out of the 18 other imidazoles without a nitro group only 2 were mutagen ...	1979	375080
spontaneous degradation of prd1 dna into unique size classes is reca dependent.	the his and nif genes of the p1 type plasmid prd1 were lost at a high frequency in a reca+ but not in a reca- escherichia coli host during growth in a non-selective medium. 92% of the his- nif- segregants after 6 subcultures retained the genetic markers of the precursor plasmid rp4, while the remainder lost all of the prd1 markers with the concomitant loss of ccc-dna. plasmids purified from the his- nif- segregants resembled rp4 in the physical and genetic properties examined. the contour length ...	1979	375020
antimicrobial therapy of septicemia due to klebsiella pneumoniae in neutropenic rats.	three different isolates of klebsiella pneumoniae, highly sensitive to amikacin but varying in susceptibility to cefazolin, were injected intraperitoneally into neutropenic rats. animals were treated every 8 hr for 72 hr with saline (controls), cefzolin (full dose, 40 mg/kg; one-fourth dose, 10 mg/kg), amikacin (full dose, 8 mg/kg; one-fourth dose, 2 mg/kg), or a combination of both drugs at either full dose or one-fourth dose. all drugs were given intramuscularly. combination therapy with full ...	1979	374646
association of tellurium resistance and bacteriophage inhibition conferred by r plasmids.	concomitant resistance to tellurium compounds (ter) and inhibition of coli-phage development (phi) are properties mediated by many h2 incompatibility group r plasmids which have been isolated from diverse bacterial and geographic sources. ter plasmids from tellurium-resistant bacteria that were isolated from sewage and industrial wastes also mediated phage inhibition. of these ter plasmids, three from citrobacter freundii belonged to the h incompatibility group, whereas three from klebsiella pne ...	1979	374351
overflow metabolism in aerobic micro-organisms.		1979	374156
endotracheally administered antibiotics for gram-negative bronchopneumonia.	sisomicin or a placebo was administered endotracheally to two groups of 18 and 20 unconscious patients, respectively, who had tracheostomies or endotracheal tubes in place and developed a severe gram-negative broncho-pneumonia. in addition, the patients received systemically a combination of sisomicin and carbenicillin. a favorable clinical response was obtained in 14 (77 percent) of the 18 patients who were treated with sisomicin and in nine (45 percent) of the 20 patients who received the plac ...	1979	374017
klebsiella pneumoniae.		1978	373650
histamine production by klebsiella pneumoniae and an incident of scombroid fish poisoning.	a histamine-producing strain of klebsiella pneumoniae was isolated from a sample of tuna sashimi implicated in an outbreak of scombroid fish poisoning. none of the other nine gram-negative bacterial strains isolated from the tuna sashimi was capable of equivalent histamine production. bacterial histamine production was monitored in a tuna fish infusion broth (tfib), and the implicated k. pneumoniae was capable of producing 442 mg of histamine per 100 g of tuna in tfib in 7 h under controlled inc ...	1979	373626
limitations of the moeller lysine and ornithine decarboxylase tests.	a total of 40 fecal and environmental isolates, including 26 escherichia coli strains, 9 members of the genus klebsiella, and 5 members of the genus enterobacter, were tested by enzyme assay for their endogenous and induced levels of lysine decarboxylase and ornithine decarboxylase when grown in moeller decarboxylase medium. all of the coliforms examined had measurable lysine decarboxylase and ornithine decarboxylase activities whether or not they were positive in the moeller test. in general, t ...	1979	373624
lymph follicular cholecystitis.	ten cases of cholecystitis with severe lymphocytic reactions were selected among serially examined 131 cases of cholecystitis or/and cholelithiasis. gram-negative bacterial infection, especially e. coli and k. pneumonia seemed to be related as the cause of these severe lymphocytic reactions, but the gallstone revealed no definite influence. we would like to separate the cases with severe lymphocytic reactions as a lymph follicular cholecystitis and consider the possibility of a gram-negative bac ...	1979	373378
[investigations on the antimicrobial activity of amine-aldehyde-condensates. 6. communication: azomethines of substituted benzaldehydes (author's transl)].	in the scope of our research about the antimicrobial activity of amin-aldehydecondensates a number of substituted benzaldehyde azomethines was synthesized by condensation of suitable benzaldehydes with primary amines (aminoethanol and n-butylamine). structures and physical constants are shown in the table 1. the antimicrobial activity is demonstrated by the results of the disk-test (table 2 and 3), of the minimal inhibition concentration test (mic, table 4) and of the suspension-disinfecting tes ...	1978	373326
experience with a quantitative carrier test for the evaluation of disinfectants.		1978	373325
[experimental studies to culture bacteria from blood specimen with an addition of ampicillin in various nutrient media (author's transl)].	ampicillin-sensitive or -resistant staphylococcus aureus and klebsiella strains were cultured in various nutrient media as prototypes of the agents of sepsis isolated in bacteriological routine analysis. in each case, 2 ml of defibrinated human blood containing 100 and 1000 cells, 8 gamma and 80 gamma ampicillin/1 ml blood respectively were added to 50 ml of nutrient medium. the following media were used. 1. casein soya-bean meal peptone broth (oxoid), 2. tryptose-phosphate medium (oxoid), 3. de ...	1978	373322
[a case of skeletal dissemination of septic foci with disastrous outcome (proceedings)].		1978	373023
integration of a transposable dna sequence which mediates ampicillin resistance into clo df13 plasmid dna: determination of the site and orientation of tna insertions.		1978	372963
antibody-coated bacteria in persistent and recurrent urinary tract infections.		1978	372670
the variable response of bacteria to excess ferric iron in host tissues.	the enhancement by exogenous ferric iron, both systemic and local, of the infectivity of 120 strains of bacteria, representing 17 genera, was measured in the skin of guinea-pigs. systemic iron enhanced only 23% of 115 strains, and local iron 49% of 71 strains. systemic iron, by an apparently anti-inflammatory action, depressed the size of lesions produced by 27 of the non-enhanced strains from nine of the genera tested. for most strains, the degree of enhancement was small, ranging from 2- to 8- ...	1979	372534
the development and assessment of a bacteriocin typing method for klebsiella.	klebsiellas are generally typed by the method of capsular serotyping but, although this is a reliable method, it is time consuming, requires the production of a large number of antisera and is not generally available. for this reason another method for typing klebsiellas was sought. a bacteriocin typing method involving mitomycin c induction was developed and the cultural conditions giving optimum klebecin production and the best methods of testing the sensitivity of the organisms to klebecins w ...	1979	372440
reproducibility of an indirect immunofluorescent-antibody technique for capsular serotyping of klebsiella pneumoniae.	reproducibility of capsular serotypes of 55 consecutive clinical isolates of klebsiella pneumoniae was evaluated by an indirect immunofluorescent-antibody technique previously described by riser et al. (j. clin. pathol. 29: 296-304, 1976) five colonies per specimen were examined for colony-to-colony variation, day-to-day variation, and reader-to-reader variation. seventy-two reference strains were tested with each of 18 pools and 72 specific antisera prior to the clinical specimens to determine ...	1979	372225
sensitivity, precision, and accuracy of the y1 adrenal cell enterotoxin assay.	the y1 adrenal cell assay for heat-labile enterotoxin (lt) was found to be relatively insensitive for filtrates of toxigenic escherichia coli h10407. when observations were made blindly and subjected to rigorous controls, reliable detection of lt occured only at filtrate dilutions from 1:4 to 1:10. detection of lt was unreliable when e. coli h10407 was mixed with another enteric organism. overall, 7.1% of observers' reports from a single assay were imprecise, and 2.6% would have resulted in erro ...	1979	372224
cefuroxime therapy for urinary tract infections caused by a multi-resistant, epidemic klebsiella aerogenes.		1979	372170
trimethoprim in combination with a sulfonamide for oral treatment of canine urinary tract infections.	trimethoprim, in combination with sulfadiazine or sulfamethoxazole was administered orally for 7 to 14 days to 84 dogs with urinary tract infections (uti). the daily dosage of 26.4 mg/kg (12 mg/lb) was divided into 2 equal parts and administered at about 12-hour intervals. response to treatment, based on negative urine culture during or after therapy, was 37 of 45 (82%) for uti caused by escherichia coli, 11 of 15 (73%) uti caused by proteus mirabilis, 8 of 12 (67%) uti caused by klebsiella pneu ...	1979	372165
klebocin typing of klebsiella pneumoniae.		1979	372098
[cefazedone in infectious diseases in gynecology. clinical tests on efficacy and tolerance].	a clinical trial on efficacy and tolerance of cefazedone, a new semisynthetic cephalosporine-derivate, was carried out in a gynaecological clinic on 75 patients. in 38 of these cases, besides the gynaecological affection, urinary tract infections were determined microbiologically (e. coli, p. mirabilis, klebsiella or enterococci). inflammation of the lower abdominal area was established in the remaining 37 patients (adnexitis, pelvic peritonitis, endometritis, salpingitis). the average duration ...	1979	372073
synthesis and excretion of polygalacturonic acid trans-eliminase in erwinia, yersinia, and klebsiella species.		1979	371775
endotoxin in germfree, gnotobiotic, or conventional-flora sprague-dawley rats.	the limulus assay for bacterial endotoxin was performed on serum and (or) plasma from animals monoassociated with clostridium species, staphylococcus aureus, escherichia coli, proteus mirabilis, enterobacter agglomerans, bacteroides fragilis, klebsiella pneumoniae, or candida albicans. plasma from animals monoassociated with the gram-negative bacteria or c. albicans consistently showed a positive limulus test while conventional-flora controls, germfree rats, and gnotobiotic animals monoassociate ...	1978	371771
bacteriocin typing of serratia marcescens. a simplified system.	the authors describe a simplified system for the detection of bacteriocin production by serratia marcescens with the use of six indicator strains, which include escherichia coli, klebsiella pneumoniae, citrobacter diversus, enterobacter aerogenes (two strains), and serratia rubidaea grown on arabinose minimal medium plates. of the 64 possible bacteriocin types, 11 were observed; 66% of the isolates tested were found to be one of three types. occasionally more than one bacteriocin type was observ ...	1979	371382
[gibbs free energy in periodic enterobacterial cultures].	the authors present the results of study of the gibbs' free energy (--delta g) output in periodic cultures of nonpathogenic and enteropathogenic escherichia, shigellae, salmonellae, proteus, serratia, and klebsiellae in the hydrolysate broth in a special twelve--chamber cultivator. graphic expression--deltag = f(n) permitted to reveal differences in the energy characteristics of individual enterobacteria genera and species. it is supposed that such studies could be useful in the choice of redox ...	1978	371306
[a new method for evaluation of beta-lactamase production of resistant enterobacteriaceae strains (author's transl)].	resistant strains of enterobacteriaceae were investigated with a chemical and microbiological test on beta-lactamase activity. the chemical method was needed as screening-test basing on the enzymatic hydrolysis of the chromogenic cephalosporin compound 87/312. the microbiological test is a modified cup plate method using staph. aureus sg 511 as sensitive test strain for penicillins and cephalosporins. in one of the two cups of the blood agar plate 20 microliter of the beta-lactam antibiotic, in ...	1978	371259
septicemia in children with cancer.	because of the persistently high mortality from sepsis in cancer patients, a retrospective study was designed to identify the causative organisms and to determine the factors affecting the outcome of sepsis. a total of 84 episodes of septicemia in 61 children with cancer were studied. the more frequently isolated organisms were: staphylococcus aureus (21.4%); escherichia coli (18%); klebsiella (7.1%); pseudomonas (6%); and bacteroides fragilis (6%). other isolates included proteus, serratia, aci ...	1979	371000
[basic and clinical examinations of cs-1170 in pediatrics (author's transl)].	1. cs-1170 was administered for the purpose of prophylaxis during cardiac catheterization in patients with heart disease, and its blood levels were measured. 2. the mean blood level (moni-trol i standard) after one intravenous shot of 20 mg/kg was 53.6 mcg/ml in catheterized children aged below 6 and 66.9 mcg/ml in catheterized children aged above 10 at 30 minutes, and 1.95 mcg/ml and 5.2 mcg/ml respectively at 6 hours. 3. the mean half life of the blood level was 1.09 hours in catheterized chil ...	1979	370423
epidemiologic and bacteriologic evaluation of neonatal necrotizing enterocolitis.	the incidence of necrotizing enterocolitis (nec) in our neonatal unit has varied from 4.7% to zero to 4.4% during three time periods. simultaneously, significant changes have occurred in the spectrum of bacterial species in the gastrointestinal tract of unaffected infants in the same unit. during the first period of increased attack rate, 82% of gastric and 88% of fecal enterobacteriaceae were e. coli and k. pneumoniae. when the attack rate decreased the frequencies were 11% (gastric) and 47% (f ...	1979	370356
thermosensitive h1 plasmids determining citrate utilization.	twelve thermosensitive h1 plasmids from strains of salmonella typhi that had caused outbreaks of chloramphenicol-resistant typhoid fever in vietnam, thailand and india mediated citrate utilization (cit+) in a prototrophic escherichia coli k12 strain but not in the s. typhi strains from which they were derived. four h1 plasmids from a similar outbreak in mexico differed from the far eastern plasmids in not mediating citrate utlization but in mediating mercury resistance. h1 plasmids resembling th ...	1978	370344
simultaneous nosocomial outbreaks caused by multiply resistant klebsiella pneumoniae types 2 and 30.	two simultaneous klebsiella pneumoniae outbreaks resistant to multiple antibiotics are reported. the closely related strains were distinguished by comparing the zone diameters obtained by disk diffusion susceptibility testing but not by interpretations of susceptible, resistant, or intermediate. similar conclusions were made when minimal inhibitory concentrations were considered. the separation was subsequently confirmed by capsular serotyping into types 2 and 30. the data presented suggest that ...	1978	370152
enzyme-linked immunospecific antibody test for detecting antibody to klebsiella.	the enzyme-linked immunospecific antibody test was performed in standard test tubes and microtiter plates to meausre high-titer antibody against klebsiella capsular polysaccharide. initial studies were conducted with rabbit sera; other studies were conducted with the serum of a patient infected with type 9 klebsiella. both immunized rabbits and an infected patient disclosed high titers of anticapsular antibody. control sera from other immunized rabbits and other infected humans failed to show t ...	1978	370145
multi-laboratory evaluation of an automated microbial detection/identification system.	an automated and computerized system (automicrobic system [ams]) for the detection of frequently encountered bacteria in clinical urine specimens was tested in a collaborative study among six laboratories. the sensitivity, specificity, reliability, and reproducibility of the ams were determined, and the system was compared with conventional detection and identification systems. in this study, pure cultures and mixtures of pure cultures were used to simulate clinical urine specimens. with pure cu ...	1978	370141
transfer by bone marrow cells of increased natural resistance to klebsiella pneumoniae induced by lipopolysaccharide in genetically deficient c3h/he mice.	in a previous study we demonstrated that lipopolysaccharide failed to elicit nonspecific resistance in c3h/he lipopolysaccharide low-responder mice against klebsiella infection in contrast to its activity in a closely related histocompatible high-responder subline, c3heb/fe. complete restoration of lipopolysaccharide-induced protection against 10(5) klebsiella was obtained in the present study by transferring bone marrow from high-responder mice to the highly deficient c3h/he mice. the ability o ...	1979	370012
dental infection in a cirrhotic patient. source of recurrent sepsis.	a patient with alcoholic cirrhosis had multiple episodes of sepsis with klebsiella pneumonia. repeated searches for the source of infection finally revealed the organism in the root of a tooth. evidence indicated that this site was the primary source of infection. the importance of dental infections in alcoholics and the difficulty in diagnosing those infections are emphasized by this case.	1979	369935
empiric therapy of febrile granulocytopenic patients.	antibiotic therapy in granulocytopenic cancer patients, the risk factors predisposing these patients to infection, and the signs, symptoms and types of infections occurring in these patients are reviewed. the four most commonly isolated organism at most cancer treatment centers are escherichia coli, klebsiella spp., pseudomonas aeruginosa and staphylococcus aureus. early antimicrobial therapy with broad-spectrum antibiotics before culture results are known produces cure rates of approximately 70 ...	1979	369364
search for cross-reacting antigens of oral acidogenic bacteria and members of the normal intestinal flora.		1978	369317
[progress in antibacterial chemotherapy].		1978	369199
[studies on the bacterial causes of neonatal mortality in foals. report on post-mortem findings (author's transl)].	the causes of neonatal mortality in foals were studied over a period of two years. the total number of foals studied was 121. bacterial infection was found to be an important factor. infection caused by a. equuli (1.6%) which previously was the most important one, has been superseded by e. coli infection (56%). e. coli infections particularly occur during the first weeks of life and, depending on the course of the disease, give rise to various pathological changes. infections running an acute co ...	1979	369036
microbial adjuvant and autoimmunity. iii. histological studies of development of experimental autoimmune thyroiditis in mice immunized with syngeneic thyroid extract together with the capsular polysaccharide of klebsiella pneumoniae.		1978	368527
chemotherapy of pneumonias.		1979	368330
the configuration and location of the ribosidic linkage in the prosthetic group of citrate lyase (klebsiella aerogenes).	the structure of the prosthetic group of citrate lyase (klebsiella aerogenes) was studied by nuclear magnetic resonance and mass spectrometry. the spectra at 360 mhz of the nucleoside moiety (2'-ribosyladenosine) show the absence of 2'-hydroxyl proton, thus confirming the 2' position as the site of attachment of the second ribose moiety to the dephospho-coa. this glycosidic linkage is found to be alpha(1" leads to 2') and is identical to that of poly(adp-ribose). studies of permethylation produc ...	1979	368065
klebsiella pneumoniae infection with secondary hypopyon in tokay gecko lizards.		1978	367993
klebsiella pneumoniae and acute anterior uveitis in ankylosing spondylitis.		1979	367506
combined clinical and laboratory studies with carbenicillin and ticarcillin: use in infections involving anaerobic bacteria.	eleven patients with serious infections involving anaerobic bacteria were treated with carbenicillin (four patients) or ticarcillin (seven patients). all patients were cured clinically and bacteriologically of their infections. an in vitro study testing 157 recently isolated anaerobic organisms against 11 antibiotics showed chloramphenicol, carbenicillin, and ticarcillin at blood level concentrations to be inhibitory to more anaerobic strains than the other eight antibiotics tested. ticarcillin ...	1978	367159
[analysis of penicillin and ampicillin resistance in bacteria i. resistance and beta-lactamase production in clinical isolates (author's transl)].	the penicillin beta-lactamase (pbl) activity of the clinical isolates was measured at the same time by colorimetric microtitration, the iodometric method and chromatographic analysis. the minimal inhibitory concentration (mic) of ampicillin (ap) was determined for each isolate, the character of the coupled resistances, their frequency and distribution in the pbl producing and pbl-negative strains were also investigated. it was found that 1. the mic value was 100 microgram/ml in 87.5 per cent of ...	1978	366997
urinary tract infection in general practice.	in three studies, 616 patients (610 female and six male) presented with symptoms suggesting urinary tract infection (uti). of these, 321 had greater than 100 x 10(6) bacteria per litre in a midstream urine sample. none of the presenting symptoms could be considered to be a reliable indicator of bacteriuria. ninety percent of infected urines and 44 percent of uninfected urines had a raised white cell concentration. escherichia coli was the most common infecting organism (71.3 percent). next were ...	1978	366474
genetic and biochemical analysis of mutants induced by bacteriophage mu dna integration into klebsiella pneumoniae nitrogen fixation genes.	polar mutations were obtained by integration of bacteriophage mu c+ or mu cts dna into the klebsiella pneumoniae nif genes located on plasmid pce1, a derivative of prd1. in addition, nif deletions were isolated from nif::mu cts plasmids. complementation data allowed the characterization of twelve nif cistrons, nine corresponding to previously identified genes. polar effect of mu dna insertions suggested the existence of at least six transcription units: 1) nif k, nif d and nif h--2)nif a and nif ...	1978	366377
[synergistic effect of ampicillin and dicloxacillin on penicillin and cephalosporin-susceptible escherichia coli (author's transl)].	an effect of a combination of ampicillin (abpc) and dicloxacillin (mdipc) on penicillins and cephalosporin-susceptible e. coli was determined. minimum inhibitory concentrations of the combined drug were as same as that of abpc, but bacterial growth was inhibited by the combined drug stronger than abpc, low activity of beta-lactamase was detected in sonicated e. coli 0.225 cells, and this activity was inhibited by relatively low concentration of mdipc. we considered that a weak synergism of the c ...	1978	366193
lysogenic conversion in klebsiella pneumoniae: system which requires active immunity regulation for expression of the conversion phenomenon.	we have previously described klebsiella pneumoniae mirm7b, which, although stably lysogenic for the inducible and nondefective phages fr2 and ap3, is not immune to superinfection by these same viruses. mira12b, a strain which is lysogenic for fr2 and ap3 and immune to superinfection, has been derived from mirm7b. the sensitivity of this strain and that of the nonimmune parent to several bacteriophages have been compared in this work. it has been found that, whereas mirm7b is sensitive to colipha ...	1978	366181
close association between shape alteration and loss of immunity to superinfection in a wild-type klebsiella pneumoniae stable lysogen which can be both immune and nonimmune to superinfection.	klebsiella pneumoniae mirm7 is a wild-type strain which grows as cocci at ph 7 and above and as rods at ph 6.5 and below. cultures of this strain and an auxotrophic derivative, mirm7b, have been found to undergo spontaneous lysis after purification from possible contaminating viruses. lysates always contained two phages, fr2 and ap3, most often at high titers. fr2 and ap3 plated with the same efficiency on both mirm7b and k59 (another k. pneumoniae strain sensitive to fr2 and ap3) and lysogenize ...	1978	366180
modulation of influenza in mice by transfer factor therapy.		1978	366134
the capsules of corynebacterium equi and streptococcus equi.	the capsules of corynebacterium equi and streptococcus equi were examined by electron microscopy after staining with ruthenium red. they were compared with the capsule of klebsiella pneumoniae which had previously been examined using the same procedure (springer & roth, 1973). the capsule of c. equi had a laminated appearance. when s. equi was grown on solid medium, its capsule appeared as radially arranged projections capped by a thick electron dense layer. when grown in liquid medium, s. equi ...	1978	366078
secondary bacterial infection in bilharzial urological patients with special reference to the effect of tartar emetic on the causative micro-organisms.		1977	366058
antibody-independent interaction of the first component of complement with gram-negative bacteria.	the interaction of the first component of complement with two serum-sensitive strains of escherichia coli and klebsiella pneumoniae was studied. it could be demonstrated that highly purified c1, free of immunoglobulin g and immunoglobulin m, binds to e. coli or k. pneumoniae. c1 binding was also found with specifically absorbed human serum, after incubation of bacteria with normal serum in the presence of ethylenediaminetetraacetate or agammaglobulinemic serum; the number of c1 molecules taken u ...	1978	365750
effect of monocontamination of germfree rats by enterotoxigenic coliform bacteria.		1979	365667
gram negative bone and joint infection: sixty patients treated with amikacin.	sixty patients with bone and joint infections secondary to gram negative infection were evaluated in relation to treatment with amikacin. forty-seven of these patients had osteomyelitis, and 13 had joint infections, including 3 prosthetic replacements. the patients' average was 35 years and there was no predilection for any particular skeletal location. only 6 patients had no associated predisposing medical problems. of these problems fracture, diabetes and narcotic abuse were most common. thirt ...	1978	365414
procedure for the simultaneous large-scale isolation of pullulanase and 1,4-alpha-glucan phosphorylase from klebsiella pneumoniae involving liquid-liquid separations.	a procedure for the simultaneous large-scale isolation of pullulanase and 1,4-alpha-glucan phosphorylase from klebsiella pneumoniae is described. the pullulanase is solubilized from the cell wall by cholate treatment; cells and cell debris are removed by partition in a poly(ethylene glycol) (peg)-dextran two-phase system and from the upper (peg) phase of this system the pullulanase is isolated by ultrafiltration and precipitation with n-cetyl,n-,n-,n-trimethyl ammonium bromide to a purity of abo ...	1978	365257
technical aspects of separation using aqueous two-phase systems in enzyme isolation processes.		1978	365256
primary klebsiella identification with macconkey-inositol-carbenicillin agar.	macconkey-inositol-carbenicillin agar has successfully been used as a primary selective medium for klebsiella enumeration. with pure cultures, nearly 100% recovery of klebsiella was observed by membrane filtration. with environmental samples using membrane filtration, 95% of typical pink- to red-colored colonies were verified as klebsiella, as opposed to only 1% of yellow background colonies. recovery of klebsiella on macconkey-inositol-carbenicillin agar was as good or better than on mendo agar ...	1978	365108
synergistic activity of gentamicin with trimethoprim or sulfamethoxazole-trimethoprim against escherichia coli and klebsiella pneumoniae.	the effect of combinations of gentamicin with trimethoprim or sulfamethoxazole-trimethoprim against clinical isolates of escherichia coli (11 strains) and klebsiella pneumoniae (12 strains) was examined by using a microdilution checkerboard technique. all isolates were susceptible to each antimicrobial agent. synergism, defined as at least a 2-log(2)-dilution lowering of the minimal inhibitory concentration of either antibiotic in the combination compared with the minimal inhibitory concentratio ...	1978	365085
acquisition of multiple antibiotic resistance by salmonella dublin from the gramnegative hospital flora, in a kidney allograft recipient.	the case of a kidney allograft recipient, who suffered from several episodes of salmonella dublin sepsis following massive immunosuppressive therapy to overcome a transplant rejection crisis, is presented. the focus of sepsis was the chronic inflamed gallbladder. the salmonella dublin strain isolated from the blood during the last episode was found to exhibit multiple resistance to antimicrobiol drugs. because the resistance phenotype was characteristic for the gramnegative flora of the universi ...	1978	364885
pathophysiologic responses to klebsiella aerogenes bacteria: 24-hour observations.		1977	364736
effect of cardiopulmonary bypass on in vivo clearance of live klebsiella aerogens.		1977	364718
variation in metabolism of biochemical test substrates by klebsiella species: an epidemiological tool.	the variation in metabolism of biochemical test substrates by klebsiella isolates has been demonstrated. it is suggested that this variation is likely to result in false-negative reactions in biochemical tests incubated for short periods. the observations made may explain the reported difficulties in obtaining reproducible results in biotyping klebsiella strains. preliminary work suggests that differences in substrate metabolism will provide a means of increasing the sensitivity of methods for t ...	1978	364067
intraventricular administration of amikacin for complicated gram-negative meningitis and ventriculitis.	four pediatric neurosurgical patients with gram-negative meningitis and ventriculitis were treated with parenteral and intraventricular amikacin, a new aminoglycoside. the organisms infecting these patients were resistant to multiple antimicrobial drugs but were sensitive to amikacin. treatment was continued for 14 days after cerebrospinal fluid cultures became negative. all four patients were cured and have demonstrated no nephrotoxicity, ototoxicity, or evidence of persistent infection on foll ...	1979	363982
nitrogenase of klebsiella pneumoniae: a pre-steady state burst of atp hydrolysis is coupled to electron transfer between the component proteins.		1978	363454
pharyngeal flora in ambulatory alcoholic patients: prevalence of gram-negative bacilli.	the pharyngeal flora of a group of ambulatory alcoholic patients was studied and compared with the pharyngeal flora of a control group. sixty-eight patients were studied, 34 alcoholics and 28 controls. of the alcoholic patients, 59% had gram-negative bacilli in their pharyngeal flora, while 14% of the control group had the same organisms. there were no differences in gram-positive cocci colonization between the groups. klebsiella pneumoniae was the most frequent isolate (40%) and the klebsiella- ...	1978	363086