Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| selection of rna-aptamer against human influenza b virus. | developing specific probes that distinguishes types and subtypes of viruses by a single probe will have a great impact not only in developing specific diagnostic reagents but also in developing tailor-made drugs and dosage requirements depending upon the genotype that cause the infection. we have selected aptamers specific for hemagglutinin protein of human influenza virus b/johannesburg/05/1999. the selected aptamer, class a-20, bind specifically to hemagglutinin of b/johannesburg/05/1999 and a ... | 2005 | 17150645 |
| safety, efficacy, and effectiveness of cold-adapted influenza vaccine-trivalent against community-acquired, culture-confirmed influenza in young children attending day care. | the goal was to evaluate the safety, tolerability, and efficacy of an investigational, refrigerator-stable formulation of live attenuated influenza vaccine (cold-adapted influenza vaccine-trivalent) against culture-confirmed influenza, acute otitis media, and effectiveness outcomes in young children in day care over 2 consecutive influenza seasons. | 2006 | 17142512 |
| human coronavirus-nl63 infections in korean children, 2004-2006. | human coronavirus-nl63 (hcov-nl63) has been isolated from children with respiratory tract infections and its prevalence in korea has not been reported. | 2007 | 17137835 |
| detection of human influenza virus in the stool of children. | 2006 | 17133173 | |
| impact of rapid viral testing for influenza a and b viruses on management of febrile infants without signs of focal infection. | the objective of this study was to assess the effect of rapid testing for influenza virus on management of febrile young infants. | 2006 | 17133161 |
| ph modulating activity of ion channels of influenza a, b, and c viruses. | the bm2 and nb proteins of influenza b virus (the b virus) and the cm2 protein of influenza c virus (the c virus) are structural homologs of the m2 protein of influenza a virus (the a virus). it was shown recently that cm2 in vitro forms a voltage-activated ion channel permeable to chloride ion (hongo et al., arch. virol. 149, 35-50, 2004). to demonstrate a possible ph modulating activity of bm2, nb and cm2, the latters were co-expressed with a ph-sensitive hemagglutinin (ha) of the a virus. bm2 ... | 2006 | 17131938 |
| human metapneumovirus infection among children in taiwan: a comparison of clinical manifestations with other virus-associated respiratory tract infections. | this study compared the clinical, laboratory and radiological features of infections caused by human metapneumovirus (hmpv) with other respiratory viruses. nasopharyngeal aspirates and throat swabs were obtained from children during a 9-week period. hmpv was the virus isolated most frequently, followed by adenovirus, influenza virus a, respiratory syncytial virus and influenza virus b. hmpv-infected children were younger, and were more likely to be female, to present with feeding difficulties, a ... | 2006 | 17121629 |
| circulation and antigenic drift in human influenza b viruses in se asia and oceania since 2000. | during annual influenza epidemics, influenza b viruses frequently co-circulate with influenza a viruses and in some years, such as 2005, large outbreaks have occurred while in other years, the virus virtually disappears. since 1987 there have been two lineages of influenza b viruses co-circulating in various countries and causing disease in humans. the proportions of these two lineages vary from year to year and country to country. for example, in 2005, the b/victoria/2/87 lineage was predominan ... | 2006 | 17120489 |
| laboratory diagnosis of human seasonal and pandemic influenza virus infection. | laboratory diagnosis is important to distinguish influenza from other respiratory virus infections. it will be especially important in detecting the first cases of pandemic influenza. good quality respiratory tract sampling is needed to maximise diagnostic yield in influenza infection. in the appropriate clinical setting, pandemic strain-specific nucleic acid testing is the initial test of choice for suspected pandemic influenza. it is more sensitive than virus isolation, and more sensitive and ... | 2006 | 17115952 |
| anti-influenza virus activity of biflavonoids. | ginkgetin was found to inhibit the influenza virus sialidase. ginkgetin-sialic acid conjugates showed a significant survival effect in the influenza-virus-infected mice. | 2007 | 17110111 |
| comparison of total white blood cell count and serum c-reactive protein levels in confirmed bacterial and viral infections. | we report the association of reaction in inflammatory markers with the microbiologic etiology of infection in children. total white blood cell counts were increased in most pneumococcal and escherichia coli infections, but in less than one-half of staphylococcus aureus infections. adenoviruses were the only viral agents that often increased total white blood cell counts or serum c-reactive protein levels. | 2006 | 17095353 |
| [peptide mapping of the monoclonal antibodies against the heavy chain hemagglutinin from influenza virus h3n2]. | interaction of the synthetic peptides corresponding to the regions 122-133, 136-147, 154-164 and 314-328 of the virus a/aichi/2/68 hemagglutinin heavy chain with monoclonal antibodies specific for this hemagglutinin was assayed in a variety of tests, e.g., elisa, competition ria, hemagglutinin-inhibition and virus-neutralization assays. the monoclonal antibody 152 reacted with the area 136-147 (epitope a), three monoclonal antibodies 3, 19 and 63 reacted exclusively with the area (154-164) glu ( ... | 2006 | 17094654 |
| [clinical features and outcome in 84 patients with influenza pneumonia]. | we examined the clinical features, illness types of pneumonia, efficacy of neuraminidase inhibitors and outcome in patients with influenza pneumonia. eighty-four patients with influenza pneumonia, in whom the diagnosis was confirmed by serology or rapid diagnostic tests, were studied. because neuraminidase inhibitors were given prior to the onset of pneumonia in some patients with secondary bacterial pneumonia, we examined the efficacy of neuraminidase inhibitors in patients other than the secon ... | 2006 | 17087332 |
| [phenotyte of epidemic influenza b virus strains isolated in different years]. | the reproducing ability at elevated temperatures (non-ts phenotype) was examined for 38 influenza b virus strains isolated in different years in different countries. out of the 7 strains isolated in 1940 to 1973, only one showed temperature-sensitivity of reproduction (a ts phenotype). in 1984 to 1988, the proportion of temperature-sensitive strains increased up to 55% (6 of 11). since the late 1990s, the majority (90%) of the study influenza b viruses demonstrated a pronounced ts phenotype. inf ... | 2006 | 17087064 |
| [acute hemorrhagic colitis induced by the neuraminidase inhibitor oseltamivir]. | a 23-year-old woman had lower abdominal pain, diarrhea and bloody stool was admitted and given a diagnosis of influenza b. her home doctor had started treatment by neuraminidase inhibitor (oseltamivir) the previous day. colonoscopic examination revealed an area of hemorrhage and erosion in the left transverse colon. after halting oseltamivir treatment these symptoms disappeared and her colonoscopic findings improved. a drug-induced lymphocyte stimulation test was positive for oseltamivir. this c ... | 2006 | 17085909 |
| response to influenza vaccine in people with non-protective hi antibody titers. | the purpose of the study was to determine which factors correlate directly with response to vaccination in such a group of subjects with non-protective hi antibody titers before vaccination. two vaccines were used, a subunit virus vaccine adjuvanted with mf59 and a split virus vaccine. the analysis indicated that immunization with vaccine adjuvanted with mf59 was an independent variable for immune response against a/h3n2 (or: 3.51; 95% ci: 1.81-6.79) and b (or: 2.31; 95% ci: 1.37-3.89). the resu ... | 2006 | 17082899 |
| estimating vaccine effectiveness against laboratory-confirmed influenza using a sentinel physician network: results from the 2005-2006 season of dual a and b vaccine mismatch in canada. | we report a case-control design using a sentinel physician network to estimate vaccine effectiveness (ve) against laboratory-confirmed, medically attended influenza (lc-mai) and provide results for the 2005-2006 season of dual a and b vaccine mismatch in canada. | 2007 | 17081662 |
| exploration of the emergence of the victoria lineage of influenza b virus. | the victoria lineage represented by b/victoria/2/87 is one of the two major distinctive haemagglutinin (ha) lineages of influenza b virus, and its recent re-emergence has aroused great concerns. however, it remains unknown when, where, and how this ha lineage emerged in the world. in this study, the ha1 domain of the ha gene of fourteen influenza b viruses isolated in china in 1972-1984 was sequenced. the sequences were phylogenetically analyzed with the ha1 sequences of 41 other important influ ... | 2007 | 17075722 |
| [evaluation of immunochromatography test for rapid detection of influenza a and b viruses using real-time pcr]. | the sensitivity of rapid diagnostic kits to influenza b is lower than to influenza a. the cause-poor performance of the kit or the scarcity of viruses in type b specimens-has yet to be clarified. using real-time pcr, we measured the amount of influenza viruses with nasopharyngeal aspirate fluid previously identified by virus isolation culture and passing the rapid diagnosis test by four types of kits, including the espline influenza a&b-n (fujirebio corp., japan). we classified the results of vi ... | 2006 | 17073266 |
| neurologic manifestations in children with influenza b virus infection. | during a 29-month period, 11 (12%) of 92 hospitalized patients with influenza b virus infection presented neurologic manifestations, which included febrile seizure in 4 cases and encephalopathy/encephalitis in 7 cases. without appropriate antiviral therapy, recovery was uneventful in all but 1 patient, who had neurologic sequelae of quadriplegia and developmental delay. | 2006 | 17072138 |
| influenza. | 2006 | 17068851 | |
| activities of oseltamivir and ribavirin used alone and in combination against infections in mice with recent isolates of influenza a (h1n1) and b viruses. | mouse models have been widely used for evaluating potential influenza virus inhibitors. however, the viral strains traditionally used in these models are fairly old and do not represent currently circulating viruses in nature. we developed two new lethal infection models in mice using mouse-adapted influenza a/new caledonia/20/99 (h1n1) and influenza b/sichuan/379/99 viruses. both virus infections were used to study oral treatment with oseltamivir and ribavirin, both alone and in combination. or ... | 2006 | 17066897 |
| characterization of various strains of influenza b virus in a neuroblastoma and a glioblastoma cell line. | although influenza b virus has been reported to be involved in central nervous system infection, little is known about the infectivity of the virus. we evaluated the ability of several strains of influenza b virus to grow in 2 nerve cell culture systems. | 2006 | 17066199 |
| [the 2005-2006 influenza season in the netherlands and the vaccine composition for the 2006-2007 season]. | the first sign of influenza activity in the netherlands during the 2005-2006 influenza season was the isolation of influenza viruses in the last week of 2005. from week 1 of 2006 onwards, an increase in clinical influenza activity was also observed that did not return to baseline levels until week 15. two waves of influenza activity were observed with peak incidences of 13.8 and 9.8 influenza-like illnesses per 10,000 inhabitants on weeks 7 and 12, respectively. the first wave of influenza was c ... | 2006 | 17061434 |
| dose-related safety and immunogenicity of baculovirus-expressed trivalent influenza vaccine: a double-blind, controlled trial in adult patients with non-hodgkin b cell lymphoma. | in 27 patients randomized to receive commercial trivalent influenza vaccine (tiv) containing 15 microg of the hemagglutinin (ha) of influenza a (h3n2 and h1n1) and b virus or a recombinant vaccine (rhao) containing 15, 45, or 135 microg of each ha, reactogenicity was minor. among patients with similar prevaccination titers, 40% given 45 microg and 60% given 135 microg of rhao developed an increase in influenza a/h3 neutralizing antibody levels; there were no increases in 4 given tiv. for each va ... | 2006 | 17054068 |
| appropriate measures of influenza immunization program effectiveness. | groll and thomson's evaluation of the effectiveness of ontario's universal influenza immunization campaign used per capita cases of laboratory-confirmed influenza. we argue that these data are susceptible to various biases and should not be used as an outcome measure. laboratory data are traditionally used to identify the presence of influenza activity rather than to identify levels of influenza activity. a better measure of viral activity is the proportion of influenza tests positive; whereas t ... | 2007 | 17052813 |
| [detection of etiologic agents and antibiotic resistance in children with acute lower respiratory tract infection in wenzhou city]. | the etiology of acute lower respiratory tract infection (lrti) in children in wenzhou city remains poorly defined. this study investigated the etiological agents responsible for acute lrti and patterns of the antibiotic resistant bacterial pathogens in children with acute lrti from wenzhou city. | 2006 | 17052392 |
| recommended composition of influenza virus vaccines for use in the 2007 influenza season. | 2006 | 17039626 | |
| phase i, randomized, controlled trial to study the reactogenicity and immunogenicity of a nasal, inactivated trivalent influenza virus vaccine in healthy adults. | we performed a randomized, placebo-controlled, dose-escalating clinical trial to evaluate the safety and immunogenicity of an inactivated, split virion, trivalent, nasal influenza vaccine using lipid/polysaccharide molecules as carriers. a total of 64 adults (mean age 29; range 19-69 years) were randomly allocated to receive a mixture of lipid/polysaccharide carrier molecules and 7.5, 15, or 30 microg hemagglutinin antigen of each of the three influenza strains (a/johannesburg/82/96 [h1n1], a/na ... | 2005 | 17038827 |
| [seasonal influenza activity in japan and epidemiological investigation for avian influenza]. | we analyzed the seasonal influenza activity in 2004/05 and 2005/06 seasons. in 2004/05 season, the prevalence of influenza started lately. the arrival of a peak of influenzal prevalence was the ninth week, and was late in comparison with an average year. the prevalence scale was very large, and the estimation number of patients was 17,700,000. since the start of the 2004/05 season, influenza activity has mainly been associated with influenza b viruses. the start of prevalence of 2005/06 season w ... | 2006 | 17038814 |
| [acute myositis associated with influenza]. | benign acute myositis associated with influenza is reported from all over the world. the characteristics of this disorder is calf pain and difficulty walking during a viral illness (3-8 days) and creatine kinase levels are mildly or moderately elevated. recovery occurred within 1 week. midchildhood (mean age: 6-8 years) is most commonly affected and boys are more commonly than girls and its ratio is 2.4 : 1 by shimizu in japan (1993). elderly patients are also reported. viral studies show that i ... | 2006 | 17037368 |
| [the molecular basis of resistance to anti-influenza drugs]. | influenza a viruses resistant to adamantanes(amantadine and rimantadine) have drastically increased in the last few years. moreover, these adamantane-resistant viruses have acquired resistance without compromising viral pathogenicity and transmissibility. viruses resistant to the other anti-influenza drugs, neuraminidase (na) inhibitors, have also been shown to emerge at a rate higher than previously thought. in addition, several recent observations suggest that human-to-human transmission of va ... | 2006 | 17037359 |
| [rapid diagnostic kits using immunochromatography for detection of influenza viruses]. | the development of rapid diagnostic kits using immunochromatography has made it possible to definitively diagnose influenza a and b simply and quickly in outpatient services. i have studied these kits using nasopharyngeal aspirates from children as samples. with the most superior kit, the sensitivity to influenza a viruses was almost 100%, and that to influenza b viruses was 90%. | 2006 | 17037357 |
| impact of a winter respiratory virus season on patients with copd and association with influenza vaccination. | we assessed the effects of an influenza season on patients with copd. data from 2,215 veterans in a multicenter, randomized, double-blind influenza vaccine efficacy study were analyzed for changes in spirometric and functional status, comparing patients with laboratory-documented influenza (ldi)-caused illness, non-ldi-caused respiratory illness, or no illness, and for association with influenza vaccination. | 2006 | 17035445 |
| synthesis and biological evaluation of dihydrofuran-fused perhydrophenanthrenes as a new anti-influenza agent having novel structural characteristic. | dihydrofuran-fused perhydrophenanthrenes were synthesized by means of o-quinodimethane chemistry with high generality and stereoselectivity, and found to exhibit potent anti-influenza activity. these compounds exerted an inhibitory effect on various strains of influenza virus growth, including influenza a and b, with a concentration dependent manner, and direct cytotoxicity was low. several biological experiments suggested that these new drugs affected a virus replication process before mrna syn ... | 2007 | 17035034 |
| semiquantitative one-step rt-pcr for simultaneous identification of human influenza and respiratory syncytial viruses. | a multiplex reverse transcription-polymerase chain reaction (mrt-pcr) method was developed for simultaneous detection and typing/subtyping of influenza viruses a/h1, a/h3 or b, and respiratory syncytial viruses a or b, followed by dna semiquantitation using the agilent 2100 bioanalyzer. such method provides a rapid, specific and sensitive diagnostic tool for detection and semiquantification of respiratory illness specimens. | 2007 | 17030067 |
| prevalence of influenza b during the 2004-2005 season in japan. | 2006 | 17029154 | |
| [molecular biology investigation of respiratory viruses as a factor of infectious complications in hemoblastosis and myelodepression]. | communicable respiratory viruses as a causative factor of infectious complication in hemoblastosis and myelodepression were investigated in 51 patients (aplastic anemia--3, multiple myeloma--10, different patterns of acute leukemia--16, chronic leukemia--8 and non-hodgkin's lymphoma--14). our clinical evidence obtained with the aid of polymerase chain reaction featured genomes of adenoviruses, influenza a and b viruses, respiratory-scintillating virus and coronaviruses. on the whole, respiratory ... | 2006 | 17024815 |
| antibody responses after dose-sparing intradermal influenza vaccination. | reduced-dose intradermal (id) influenza vaccination is an attractive approach to increase availability of vaccine supply in an event of vaccine shortage. we conducted a randomized open-label study, in which 500 subjects were randomly assigned to receive an id injection of 0.1 ml dose of inactivated split-virion influenza vaccine or an im injection of 0.5 ml dose. the subjects who had hemagglutination inhibition (hi) antibody titer of at least 1:40 at day 28 post-vaccination in id and im groups w ... | 2007 | 17011678 |
| [antiviral therapy: from influenza to pfeiffer's disease]. | antiviral drug therapy has rapidly evolved in recent years. a large number of specific inhibitors against newly detected viral targets has been developed. viral infections except hiv and viral hepatitis infections are clinically relevant mostly in severely immunocompromised patients. especially respiratory viral infections and herpes virus infections are associated with high morbidity and mortality in these patients. therapeutic and preventive strategies have been developed for a number of these ... | 2006 | 17009040 |
| lack of correlation between nutritional status and seroprotection against influenza in a long term care facility. | we conducted a prospective study in a long-term care facility. virologic diagnosis was assessed using viral isolation, polymerase chain reaction and serology for all patients with a flu-like syndrome. albumin, vitamins and trace elements were also measured. results: the risk of influenza increased 6.5-fold in patients with an antibody titer of 40 during the influenza outbreak (p=0.04). micronutrients and vitamins deficiencies were important. patients with antibody titer >1:40 could still be infe ... | 2006 | 17008234 |
| superior relative efficacy of live attenuated influenza vaccine compared with inactivated influenza vaccine in young children with recurrent respiratory tract infections. | young children have a high incidence of influenza and influenza-related complications. this study compared the efficacy and safety of cold-adapted influenza vaccine, trivalent (caiv-t) with trivalent inactivated influenza vaccine (tiv) in young children with a history of recurrent respiratory tract infections (rtis). | 2006 | 17006279 |
| comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma. | despite their potential for increased morbidity, 75% to 90% of asthmatic children do not receive influenza vaccination. live attenuated influenza vaccine (laiv), a cold-adapted, temperature-sensitive, trivalent influenza vaccine, is approved for prevention of influenza in healthy children 5 to 19 years of age. laiv has been studied in only a small number of children with asthma. | 2006 | 17006278 |
| comparison of multiplex pcr assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness. | the performances of four multiplex pcr (m-pcr) were compared to direct immunofluorescence assay (dfa) and huh7 cell culture for the detection of viruses in 263 children admitted to hospital with an acute respiratory illness. one hundred fifty (57.6%) nasal aspirates were found dfa-positive; 188 (72.3%) were found positive by both dfa and huh7 cell culture, and 242 (92%) were pcr-positive. the m-pcr detected 124 viruses which were not found by conventional methods: 68 rhinovirus, 17 human metapne ... | 2006 | 16998894 |
| clinical study of influenza-associated rhabdomyolysis with acute renal failure. | influenza-associated rhabdomyolysis induces renal failure with a fatal outcome. the aim of this study is to evaluate the clinical features, diagnosis, and treatment efficacy of influenza-associated rhabdomyolysis patients with acute renal failure (arf). | 2006 | 16995338 |
| update: influenza activity--united states and worldwide, may 21-september 9, 2006. | in the united states, cdc uses seven systems for national influenza surveillance, four of which operate year-round: 1) the world health organization (who) and the national respiratory and enteric virus surveillance system (nrevss) collaborating laboratory systems; 2) the u.s. influenza sentinel provider surveillance system; 3) the 122 cities mortality reporting system; and 4) a national surveillance system that records pediatric deaths associated with laboratory-confirmed influenza. data from th ... | 2006 | 16988642 |
| double-stranded rna binding of influenza b virus nonstructural ns1 protein inhibits protein kinase r but is not essential to antagonize production of alpha/beta interferon. | expression of alpha/beta interferon (ifn-alpha/beta) in virus-infected vertebrate cells is a key event in the establishment of a sustained antiviral response, which is triggered by double-stranded rna (dsrna) produced during viral replication. these antiviral cytokines initiate the expression of cellular proteins with activities that limit the replication and spread of the invading viruses. within this response, the dsrna-dependent protein kinase r (pkr) that is expressed at constitutive levels ... | 2006 | 16987984 |
| influenza b viruses isolated in uruguay during the 2002-2005 seasons: genetic relations and vaccine strain match. | monitoring antigenic and genetic variations of circulating influenza viruses is critical for the selection of annual vaccine strains. in order to gain insight into the molecular evolution of influenza b viruses (ibv) isolated in uruguay in 2002 and 2005 outbreaks, antigenic and phylogenetic studies were carried out for the hemagglutinin (ha) gene. antigenic relations among uruguayan and reference strains isolated elsewhere were performed by means of hemagglutination inhibition assays (hai). gene ... | 2007 | 16987563 |
| 14-3-3 protein detection in the cerebrospinal fluid of patients with influenza-associated encephalopathy. | influenza-associated encephalopathy is characterized by high fever, convulsions, and loss of consciousness associated with influenza infection in children, but its pathophysiology remains to be clarified. we examined 14-3-3 proteins, which are acidic brain proteins, in cerebrospinal fluid by immunoblotting in four patients with influenza-associated encephalopathy, four patients with influenza without encephalopathy, and four patients with another encephalopathy. interestingly, we detected 14-3-3 ... | 2006 | 16970844 |
| surveillance for influenza admissions among children hospitalized in canadian immunization monitoring program active centers, 2003-2004. | influenza is a common childhood infection that may result in hospitalization. our objectives were to (1) determine characteristics of children hospitalized for influenza and disease manifestations and (2) obtain baseline data before implementation of new recommendations for routine immunization of young children and their caretakers against influenza. | 2006 | 16950953 |
| immunization with trivalent inactivated influenza vaccine in partially immunized toddlers. | children > or = 6 months of age who have previously received 1 dose of trivalent inactivated influenza vaccine are recommended to be given an additional single trivalent inactivated influenza vaccine dose the following fall. limited data exist documenting the immunogenicity of 2 doses of influenza vaccine given in separate years to young children, and it is not known if the antigen content of each of the 2 doses of vaccine must be identical or similar to optimally immunize children in this age g ... | 2006 | 16950949 |
| influenza vaccine immunogenicity in 6- to 23-month-old children: are identical antigens necessary for priming? | immunoprophylaxis with influenza vaccine is the primary method for reducing the effect of influenza on children, and inactivated influenza vaccine has been shown to be safe and effective in children. the advisory committee on immunization practices recommends that children 6 to 23 months of age who are receiving trivalent inactivated influenza vaccine for the first time be given 2 doses; however, delivering 2 doses of trivalent inactivated influenza vaccine > or = 4 weeks apart each fall can be ... | 2006 | 16950948 |
| [genetic stability of cold-adapted influenza viruses]. | the stability of cold adaptation, temperature-sensitivity, and marker mutations that are typical of attenuated influenza a and b viruses--master donor strains and their based reassortant vaccine strains was studied. after 5 sequential passages in chick embryos (ce) at resolving temperatures of 32 and 37 degrees c, the master donor strains and vaccine viruses retained their adaptability and temperature sensitive phenotype. passage at the temperatures maximally permissible for viral reproduction ( ... | 2006 | 16929592 |
| etiology of influenza viruses isolated in russia from 1998 up to present time. | influenza epidemic events in russia from 1998 up to 2005 were associated with the circulation of influenza a (h3n2), a (h1n1) and b viruses. the antigenic analysis revealed that the evolution of a (h3n2) viruses proceeded as following: a/sydney/05/97-->a/panama/2007/99-->a/fujian/411/02-->a/wellington/01/04; a (h1n1) viruses: a/bayern/07/95-->a/bejing/262/95-->a/new caledonia/20/99; b viruses evolved as two distinct lineages: victoria- and yamagata-like viruses. our results have shown that the e ... | 2006 | 16920234 |
| early detection of a/california/7/2004-like a(h3n2) strains in norway during the 2004-2005 season, and emergence of a novel h3n2 genetic sub-variant toward the end. | influenza activity in norway during the 2004-2005 season was unusually slow in its development despite the early occurrence of an influenza a(h3n2) drift variant. analysis of initial import and domestic cases in august-november gave early warning of a novel influenza a(h3n2) antigenic variant that had drifted further than the southern hemisphere a/wellington/1/2004-like strains, and this novel variant, subsequently represented by the a/california/7/2004 vaccine strain, came to predominate in the ... | 2006 | 16920231 |
| rhabdomyolysis and acute renal failure associated with influenza virus type b infection. | a patient with rhabdomyolysis-induced acute renal failure due to influenza b virus infection is presented. influenza b infection caused rhabdomyolysis with efflux of myoglobin from myocytes, causing acute renal failure. in conclusion, influenza virus type b can cause severe rhabdomyolysis leading to acute renal failure. | 2006 | 16909056 |
| experimental evaluation of the fluchip diagnostic microarray for influenza virus surveillance. | global surveillance of influenza is critical for improvements in disease management and is especially important for early detection, rapid intervention, and a possible reduction of the impact of an influenza pandemic. enhanced surveillance requires rapid, robust, and inexpensive analytical techniques capable of providing a detailed analysis of influenza virus strains. low-density oligonucleotide microarrays with highly multiplexed "signatures" for influenza viruses offer many of the desired char ... | 2006 | 16891504 |
| robust sequence selection method used to develop the fluchip diagnostic microarray for influenza virus. | dna microarrays have proven to be powerful tools for gene expression analyses and are becoming increasingly attractive for diagnostic applications, e.g., for virus identification and subtyping. the selection of appropriate sequences for use on a microarray poses a challenge, particularly for highly mutable organisms such as influenza viruses, human immunodeficiency viruses, and hepatitis c viruses. the goal of this work was to develop an efficient method for mining large databases in order to id ... | 2006 | 16891503 |
| increasing appearance of reassortant influenza b virus in taiwan from 2002 to 2005. | genetic and antigenic analyses of influenza b virus field strains isolated in taiwan from 1998 to 2005 were performed. to investigate the molecular evolution of influenza b viruses, sequence analysis of the hemagglutinin (ha1 subunit) and neuraminidase genes was performed. all influenza b viruses isolated between 1998 and 2000 belonged to the b/yamagata/16/88 lineage. the b/victoria/2/87 lineage, which was cocirculating with the yamagata lineage, was identified in taiwan in march 2001. concurren ... | 2006 | 16891481 |
| the association of newly identified respiratory viruses with lower respiratory tract infections in korean children, 2000-2005. | this study was performed to evaluate the associations of newly recognized viruses, namely, human metapneumovirus (hmpv), human coronavirus (hcov)-nl63, and human bocavirus (hbov) with lower respiratory tract infections (lrtis) in previously healthy children. | 2006 | 16886150 |
| prevention and control of influenza: recommendations of the advisory committee on immunization practices (acip). | this report updates the 2005 recommendations by the advisory committee on immunization practices (acip) regarding the use of influenza vaccine and antiviral agents (cdc. prevention and control of influenza: recommendations of the advisory committee on immunization practices [acip]. mmwr 2005;54[no. rr-8]:1--44). the 2006 recommendations include new and updated information. principal changes include 1) recommending vaccination of children aged 24-59 months and their household contacts and out-of- ... | 2006 | 16874296 |
| influenza vaccination in patients with breast cancer: a case-series analysis. | our aim was to evaluate the serological response and safety of influenza vaccine in patients with breast cancer in mexico. | 2006 | 16865064 |
| genomic analysis of influenza a viruses, including avian flu (h5n1) strains. | this study was designed to conduct genomic analysis in two steps, such as the overall relative synonymous codon usage (rscu) analysis of the five virus species in the orthomyxoviridae family, and more intensive pattern analysis of the four subtypes of influenza a virus (h1n1, h2n2, h3n2, and h5n1) which were isolated from human population. all the subtypes were categorized by their isolated regions, including asia, europe, and africa, and most of the synonymous codon usage patterns were analyzed ... | 2006 | 16858618 |
| viral etiology of pneumonia in a cohort of newborns till 24 months of age in rural mirzapur, bangladesh. | limited information is available on the etiology of acute lower respiratory infection (alri) particularly pneumonia in the rural community of developing countries since most etiological studies are carried out in the hospital settings. this study examined the etiology of pneumonia among young children in a rural community of bangladesh. a cohort of 252 newborns was followed till 24 months of age during 1993-1996. community health workers (chws) identified cases of alri during household surveilla ... | 2006 | 16857616 |
| rapid identification of small interfering rna that can effectively inhibit the replication of multiple influenza b virus strains. | influenza b virus is a cause of substantial morbidity and mortality in humans and current vaccination strategies and antiviral drugs only provide limited protection. here, we report the evaluation of small interfering rna (sirna) for repression of viral replication in cultured cells as well as in chicken embryos. several sirnas targeting conserved regions of the virus (in chemically synthesized or plasmid-encoded forms) were found to effectively block the replication of the influenza b virus. th ... | 2006 | 16856616 |
| hhs-cdc news: update: influenza activity--us and worldwide, 2005-2006 season, and composition of the 2006-2007 influenza vaccine. | 2006 | 16849615 | |
| insights into the interaction between influenza virus and pneumococcus. | bacterial infections following influenza are an important cause of morbidity and mortality worldwide. based on the historical importance of pneumonia as a cause of death during pandemic influenza, the increasingly likely possibility that highly pathogenic avian influenza viruses will trigger the next worldwide pandemic underscores the need to understand the multiple mechanisms underlying the interaction between influenza virus and bacterial pathogens such as streptococcus pneumoniae. there is am ... | 2006 | 16847087 |
| annual report of the national influenza surveillance scheme, 2005. | surveillance of influenza in australia is based on laboratory isolation of influenza viruses, sentinel general-practitioner reports of influenza-like illness, and absenteeism data from a major national employer. in 2005, 4,575 cases of laboratory-confirmed influenza-like illness were reported, which was 115 per cent higher than in 2004. the influenza season started in the first week of june, with peak activity in early august, a month earlier than in 2004. influenza a was the predominant type no ... | 2006 | 16841500 |
| a comparison of the effectiveness of oseltamivir for the treatment of influenza a and influenza b: a japanese multicenter study of the 2003-2004 and 2004-2005 influenza seasons. | to compare the effectiveness of oseltamivir for treatment of influenza a and influenza b, we conducted a prospective, multicenter study of the 2003-2004 and 2004-2005 influenza seasons. the study included 3351 patients in whom influenza had been diagnosed by use of an antigen detection test kit. | 2006 | 16838232 |
| bordetella pertussis and mixed infections. | in pertussis-like respiratory infections, once pertussis has been laboratory confirmed, other potential causative pathogens will seldom be looked for. probably most mixed infections are found accidentally and since these mixed infections might cause a more severe disease we performed a retrospective study of their incidence. | 2006 | 16835573 |
| the safety and efficacy of dose-sparing intradermal administration of influenza vaccine in human immunodeficiency virus-positive patients. | 2006 | 16832008 | |
| the effect of giving influenza vaccination to general practitioners: a controlled trial [nct00221676]. | no efficacy studies of influenza vaccination given to gps have yet been published. therefore, our purpose was to assess the effect of an inactivated influenza vaccine given to gps on the rate of clinical respiratory tract infections (rtis) and proven influenza cases (influenza positive nose and throat swabs and a 4-fold titre rise), while adjusting for important covariates. | 2006 | 16831228 |
| [etiology of influenza according to the data of serological diagnostics in hospital patients in st. petersburg at the period of 1968 - 2000]. | the specific features of the etiology of influenza in children and adults at the period of the simultaneous circulation of two subtypes of influenza virus a, according to the results in the hemagglutination-inhibition reaction in 261,490 influenza and ard patients hospitalized in st. petersburg in the course of 32 years, were analyzed. the results of serological diagnostics was shown to correspond to the data of the identification of influenza viruses in russia and all over the world. at the per ... | 2006 | 16830588 |
| evaluation of the quidel quickvue test for detection of influenza a and b viruses in the pediatric emergency medicine setting by use of three specimen collection methods. | the quidel quickvue influenza test was compared to viral culture and reverse transcriptase pcr by the use of three different respiratory specimen types. of 122 pediatric subjects enrolled, 59 had influenza virus infections: 44 were infected with influenza a virus and 15 were infected with influenza b virus. the sensitivity of the quickvue test was 85% with nasopharyngeal swabs, 78% with nasal swabs, and 69% with nasopharyngeal washes. specificities were equivalent (97% to 98%) for all three coll ... | 2006 | 16825402 |
| eccentric exercise as an adjuvant to influenza vaccination in humans. | the immune response to vaccination in animals can be enhanced by exposure to acute stress at the time of vaccination. the efficacy of this adjuvant strategy for vaccination in humans requires investigation. the current study employed a randomised controlled trial design to examine the effects of eccentric exercise prior to influenza vaccination on the antibody and cell-mediated responses. sixty young healthy adults (29 men, 31 women) performed eccentric contractions of the deltoid and biceps bra ... | 2007 | 16824730 |
| adjuvant effect of bacillus firmus in intranasal immunization of guinea pigs with inactivated type b infuenza virus. | intranasal immunization of guinea pigs with inactivated type b influenza virus plus inactivated bacillus firmus as an adjuvant compared to the virus alone yields higher titers of serum hemagglutination-inhibiting antibodies and virus-neutralizing antibodies. this phenomenon could be useful in standard serology, especially in the preparation of immune sera against highly pathogenic strains for in vitro diagnosis. | 2006 | 16821727 |
| [antigenic and genetic study of influenza virus b circulated in china in 2004-2005]. | to analyze the genetic and antigenic characteristics of hemagglutinin (ha) gene of human influenza b virus isolated from the mainland of china since 2004-2005. | 2006 | 16816852 |
| [influenza, an existing public health problem]. | seasonal influenza is an acute and recurring respiratory disease known since ancient times, occuring, in particular, during winter months and having an elevated effect on public health worldwide. the disease has high morbidity rates for people of all ages and particularly high mortality rates for children, adults over 60 years old, patients with chronic illnesses and pregnant women. prevention control strategies include vaccination using inactivated, subunit or genetically modified virus vaccine ... | 2006 | 16813133 |
| seasonal influenza activity for 2005-2006 season seems to be ending in most european countries. | 2006 | 16809823 | |
| statement on influenza vaccination for the 2006-2007 season. an advisory committee statement (acs). | 2006 | 16805064 | |
| influenza-related hospitalizations in children younger than three years of age. | to determine the rates of influenza-related hospitalization and to know the clinical manifestations and underlying diseases in children younger than 3 years who are hospitalized with influenza. | 2006 | 16804428 |
| a randomized, double-blind study of the safety, transmissibility and phenotypic and genotypic stability of cold-adapted influenza virus vaccine. | live attenuated influenza vaccine (laiv; flumist) is a trivalent vaccine containing cold-adapted influenza vaccine viruses that infect and replicate in cells lining the nasopharynx to induce immunity. recovery of viruses (shedding) is measured by culture of nasal specimens. shedding of vaccine viruses is not equated with transmission because transmission requires more virus than is detected in many nasal swabs. previous studies with laiv did not detect transmission to close contacts. the primary ... | 2006 | 16804427 |
| clinical influenza activity in europe is still low, with influenza b virus being dominant: an update from eiss. | 2006 | 16804211 | |
| detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their use. | emergence of influenza viruses with reduced susceptibility to neuraminidase inhibitors (nais) develops at a low level following drug treatment, and person-to-person transmission of resistant virus has not been recognized to date. the neuraminidase inhibitor susceptibility network (nisn) was established to follow susceptibility of isolates and occurrence of nai resistance at a population level in various parts of the world. isolates from the who influenza collaborating centers were screened for s ... | 2006 | 16801417 |
| influenza in children. | excess mortality associated with annual influenza epidemics is highest among persons over 65 y of age, and therefore influenza is often regarded as an illness of the elderly population. ample evidence indicates, however, that the burden of influenza is also substantial in children, and that children have a central role in the spread of influenza in the community during epidemics. vaccination of children against influenza could bring about substantial health benefits not only to children themselv ... | 2006 | 16801171 |
| field performance and new uses of rapid influenza testing in thailand. | rapid influenza tests are increasingly used in surveillance systems and for clinical care in southeast asia. however, the performance and utility of rapid influenza tests under field conditions in rural southeast asia has not been evaluated. | 2007 | 16798041 |
| [influenza surveillance from 1999 to 2005 in liaoning regions]. | to investigate the prevalence and subtypes of influenza viruses in liaoning regions from november 1999 to march 2005. | 2006 | 16792894 |
| frequency and effects of bacterial infection in children with influenza under oseltamivir treatment. | new antiviral drugs can rapidly improve the symptoms of influenza, but some patients still have prolonged fever and complications. the cause of the prolonged symptoms despite antiviral therapy remains unclear. recent studies have shown a synergistic effect between influenza viruses and bacteria. this study investigated the frequency of bacterial infection in such patients and its effects on the clinical course to determine the need for antibiotics. | 2006 | 16790978 |
| [diagnostics of viral respiratory infections in hospitalized patients and ambulatory patients from sentinel program during 2004/05 season in poland]. | the aim of the study was to evaluate an impact of respiratory infections on the study population, type/subtype of influenza viruses circulating during 2004/05 season within the groups of hospitalised (n=35) and ambulatory patients (n=420) and to determine antigenic affinity of isolated viral strains. laboratory diagnostics of influenza a and b type, rsv, adenovirus and parainfluenzavirus (type 1, 2 and 3) was performed using direct immunofluorescence test (difa), virus isolation on mdck cell lin ... | 2005 | 16789521 |
| genetic recombination for antigenic markers of antigenically different strains of influenza b virus. | incorporation of trypsin in agar overlay or fluid maintenance media resulted in enhancement of plaquing efficiency and replication of influenza b viruses in primary chicken embryo fibroblasts. using this improved technique, recombination was attempted with two serologically distinct strains of influenza b virus, b/lee/40 and b/massachusetts/1/71. after mixed infection, two virus clones were selected and characterized in detail. hemagglutination inhibition and neuraminidase inhibition tests showe ... | 1974 | 16789141 |
| histopathologic and immunohistochemical features of fatal influenza virus infection in children during the 2003-2004 season. | the centers for disease control and prevention enhanced national surveillance for influenza-associated deaths among children because of early reports of pediatric deaths during the 2003-2004 influenza season. | 2006 | 16779738 |
| update: influenza activity--united states and worldwide, 2005-06 season, and composition of the 2006-07 influenza vaccine. | during the 2005-06 influenza season, influenza a (h1n1), a (h3n2), and b viruses cocirculated worldwide. in the united states, influenza a (h3n2) viruses predominated overall, but influenza b viruses were isolated more frequently than influenza a viruses late in the season. influenza activity in the united states peaked in early march, and the number of pneumonia and influenza deaths did not exceed the epidemic threshold. worldwide, influenza b viruses were the most commonly reported influenza t ... | 2006 | 16775576 |
| influenza vaccination and the production of anti-phospholipid antibodies in patients with systemic lupus erythematosus. | 2006 | 16766374 | |
| influenza virus proton channels. | the m2 ion channel proteins of influenza a and b viruses are essential to viral replication. the two ion channels share a common motif, hxxxw, that is responsible for proton selectivity and activation. the ion channel for the influenza a virus, but not influenza b virus, is inhibited by the antiviral drug amantadine and amantadine-resistant escape mutants form in treated influenza a patients. the studies reviewed suggest that an antiviral compound directed against the conserved motif would be mo ... | 2006 | 16761092 |
| epidemiological and virological assessment of influenza activity in europe, during the 2004-2005 winter. | the 2004-2005 influenza season in europe started in late december 2004 and the first influenza activity occurred in the west and southwest (spain, united kingdom and ireland). influenza activity then moved gradually east across europe during january and early february 2005, and from late february until late march, most movement was south to north. the intensity of clinical influenza activity in ten out of 23 countries was higher than during the 2003-2004 season, and lower or equal to the 2003-20 ... | 2006 | 16757850 |
| [internal epidemic influenza virus proteins: isolation and investigation]. | the internal influenza virus proteins m1 and rnp free from surface protein impurities were isolated from subviral particles (virions free from ha and na ectomenes). the spikeless particles had no propensity to aggregate in the solution at ph 5.0 as compared with native viruses. the subviral particles of b/hong kong/330/01 influenza virus, which belonged to b/victoria/2/87-lineage, were obtained by proteolytic treatment with the enzyme bromelain under the same conditions as in cases of influenza ... | 2006 | 16756174 |
| an efficient rna aptamer against human influenza b virus hemagglutinin. | aptamers are known for their higher discriminating ability between closely related molecules and their requirement for only a small region for binding, as compared to an antibody. in the present studies, we have isolated a specific rna aptamer against the influenza virus b/johannesburg/05/1999 by an in vitro selection procedure. the aptamer bound efficiently to the ha of influenza b and required 5 mm mgcl(2) ion for its recognition. the aptamer not only distinguished ha derived from the influenz ... | 2006 | 16751591 |
| molecular analysis of isolates from influenza b outbreaks in the u.s. and nepal, 2005. | currently circulating influenza b viruses can be divided into two antigenically and genetically distinct lineages referred to by their respective prototype strains, b/yamagata/16/88 and b/victoria/2/87, based on amino acid differences in the hemagglutinin surface glycoprotein. during may and july 2005, clinical specimens from two early season influenza b outbreaks in arizona and southeastern nepal were subjected to antigenic (hemagglutinin inhibition) and nucleotide sequence analysis of hemagglu ... | 2006 | 16736092 |
| [clinical and epidemiological characteristics of respiratory virus infections among adults hospitalized during 2004 influenza season]. | during yearly influenza (flu) season, flu viruses are well represented among hospitalized patients as in the community. also, other respiratory viruses could be represented among adult in-patients. aim: to describe the presence and clinical- epidemiological characteristics of non-flu respiratory virus infections (respiratory syncytial-rsv, parainfluenza and adenovirus-adv) among hospitalized adults during flu season and to compare with flu-a (ia) or -b (ib) cases. | 2006 | 16721443 |
| safety of high doses of influenza vaccine and effect on antibody responses in elderly persons. | immune responses after influenza immunization are reduced in elderly individuals, the group at greatest risk for complications and death after influenza. improved vaccines are needed to address this problem. | 2006 | 16717175 |