Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| the structure-function relationships of complement receptor type 2 (cr2; cd21). | human complement receptor type 2 (cr2; cd21) is a surface-associated glycoprotein which binds to a variety of endogenous ligands, including the complement component c3 fragments ic3b, c3dg and c3d, the low-affinity ige receptor cd23, and the type i cytokine, interferon-alpha. cr2 links the innate complement-mediated immune response to pathogens and foreign antigens with the adaptive immune response by binding to c3d that is covalently attached to targets, and which results in a cell signalling p ... | 2016 | 26916158 |
| in epstein-barr virus-associated gastric carcinoma a high density of cd66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis. | epstein-barr virus-associated gastric carcinoma (ebvagc) is characterized by prominent intratumoral lymphocyte infiltration, with some infiltration by other types of inflammatory cells, such as neutrophils. in this study, the significance of tumor-associated neutrophils (tans) and cytotoxic t lymphocytes (ctls) was investigated in ebvagc. cd66b-positive tans and cd8-positive ctls in surgically resected ebvagc tissues were evaluated by immunohistochemistry and digital imaging analysis. cut-off va ... | 2016 | 26915031 |
| outcomes for paediatric burkitt lymphoma treated with anthracycline-based therapy in malawi. | burkitt lymphoma (bl) is the most common paediatric cancer in sub-saharan africa (ssa). anthracyline-based treatment is standard in resource-rich settings, but has not been described in ssa. children ≤18 years of age with newly diagnosed bl were prospectively enrolled from june 2013 to may 2015 in malawi. staging and supportive care were standardized, as was treatment with chop (cyclophosphamide, doxorubicin, vincristine, prednisone) for six cycles. among 73 children with bl, median age was 9·2 ... | 2016 | 26914979 |
| migration and multiple sclerosis in immigrants from united kingdom and ireland to australia: a reassessment. iii: risk of multiple sclerosis in uki immigrants and australian-born in hobart, tasmania. | our previous work suggested that migrants from the united kingdom and ireland (uki) to australia who left their home country at a young age had a longer interval between immigration and onset and likely acquired ms in australia. in the present study, we reassessed australian-born cases of ms identified in hobart, tasmania, a relatively high-risk zone, in our 1981 survey and compared these with cases of ms in uki immigrants incident in australia. the incidence of ms in australian-born residents r ... | 2016 | 26914927 |
| hydroa vacciniforme-like ebv-positive cutaneous t-cell lymphoma, first report of 2 cases in ecuador. | hydroa vacciniforme-like cutaneous lymphoma is a very rare epstein-barr virus positive peripheral t-cell lymphoma affecting asian and hispanic children and young adults with a defective cytotoxic immune response to ebv predisposing to the development of the disease. we report on 2 ecuadorian patients with papulovesicular and ulcerated crusted lesions on the face, upper and lower extremities and abdomen, with aggressive clinical course and, in one case, a fatal outcome. the histological and molec ... | 2016 | 26913846 |
| [research advances on extranodal nasal type nk/t cell lymphoma--review]. | extranodal nk/t cell lymphoma is a relatively uncommon type of non-hodgkin's lymphoma, which is prevalently distributed in asia and south america, and is highly associated with epstein-barr virus (ebv) infection. due to its highly aggressive course and poor response to treatment because of its multi-drug resistance, for the timebeing there is not yet a definite treatment strategy. the clinical manifestation, pathological diagnosis and the progress of treatment methods of entnkcl are reviewed bel ... | 2016 | 26913435 |
| assessment of epstein-barr virus nucleic acids in gastric but not in breast cancer by next-generation sequencing of pooled mexican samples. | gastric (gc) and breast (brc) cancer are two of the most common and deadly tumours. different lines of evidence suggest a possible causative role of viral infections for both gc and brc. wide genome sequencing (wgs) technologies allow searching for viral agents in tissues of patients with cancer. these technologies have already contributed to establish virus-cancer associations as well as to discovery new tumour viruses. the objective of this study was to document possible associations of viral ... | 2016 | 26910355 |
| bart mirnas: an unimaginable force in the development of nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a head and neck cancer that represents a major health burden in southern china and southeast asia. although the close association of npc with epstein-barr virus (ebv) infection has been demonstrated, its exact role in the pathogenesis of this malignancy is still unclear. the expression of ebv-encoded micrornas, especially bart mirnas, which are encoded from the bamhi-a region of the viral genome, is detected at a high level in npc. mirnas are small noncoding mrn ... | 2017 | 26909566 |
| an ebv recombinant deleted for residues 130-159 in ebna3c can deregulate p53/mdm2 and cyclin d1/cdk6 which results in apoptosis and reduced cell proliferation. | epstein-barr virus (ebv), a gamma herpes virus is associated with b-cell malignancies. ebna-3c is critical for in vitro primary b-cell transformation. interestingly, the n terminal domain of ebna3c which contains residues 130-159, interacts with various cellular proteins, such as p53, mdm2, cyclind1/cdk6 complex, and e2f1. in the current reverse genetics study, we deleted the residues 130-159 aa within ebna3c open reading frame (orf) by bacmid recombinant engineering methodology. our experiments ... | 2016 | 26908453 |
| cytokines and persistent viral infections. | intracellular pathogens such as the human immunodeficiency virus, hepatitis c and b or epstein-barr virus often cause chronic viral infections in humans. persistence of these viruses in the host is associated with a dramatic loss of t-cell immune response due to functional t-cell exhaustion. developing efficient immunotherapeutic approaches to prevent viral persistence and/or to restore a highly functional t-cell mediated immunity remains a major challenge. during the last two decades, numerous ... | 2016 | 26907634 |
| infectious mononucleosis triggers generation of igg auto-antibodies against native myelin oligodendrocyte glycoprotein. | a history of infectious mononucleosis (im), symptomatic primary infection with the epstein barr virus, is associated with the development of autoimmune diseases and increases the risk to develop multiple sclerosis. here, we hypothesized that immune activation during im triggers autoreactive immune responses. antibody responses towards cellular antigens using a hep-2 based indirect immunofluorescence assay and native myelin oligodendrocyte glycoprotein (mog) using a flow cytometry-based assay wer ... | 2016 | 26907324 |
| [epstein-barr virus associated acute retinal necrosis]. | this article reports a case of an epstein-barr virus (ebv) associated acute retinal necrosis. a 72-year-old male patient presented in the emergency department complaining of progressive loss of vision. during patient management an acute retinal necrosis was suspected and the subsequent diagnostics from a vitreal body biopsy showed positive results only for the ebv genome. | 2016 | 26906153 |
| protective role of interleukin 27 (il-27) gene polymorphisms in patients with ulcerative colitis. | ulcerative colitis (uc) is a chronic condition of unknown etiology and a polygenic disease. the interleukin 27 (il-27) have been implicated in the pathogenesis of several autoimmune diseases including inflammatory bowel disease. several polymorphisms of il-27 have been associated with several types of cancer and immune disorders. the aim of the present study was to evaluate the association between il-27 gene polymorphisms and the development of uc. four polymorphisms of il-27p28 gene (rs181206, ... | 2016 | 26905929 |
| bk virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation in the pediatric population. | to study the incidence, risk factors, and treatment of hemorrhagic cystitis secondary to bk-virus reactivation (hc-bkv) after allogeneic hematopoietic stem cell transplantation (allo-hsct) in the pediatric population. | 2016 | 26902502 |
| are hla-e*0103 alleles predictive markers for nasopharyngeal cancer risk? | nasopharyngeal carcinoma (npc) is a particular entity of head neck cancer, tightly related to epstein-barr virus infection and thus to hla genes. in this study, we aimed to analyze hla-e polymorphism in npc advent and prognosis. 130 unrelated patients with cnp and 180 unrelated and healthy controls were included in our study. hla-e genotyping was performed by pcr/rflp method; spss (13.0) was used for statistical analysis, and survival curbs were established with the "kaplan-meier" method (log ra ... | 2016 | 26896927 |
| serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis. | to assess in an observational study whether serum peptide antibody reactivities may distinguish aquaporin-4 (aqp4) antibody (ab)-positive and -negative neuromyelitis optica spectrum disorders (nmosd) and relapsing-remitting multiple sclerosis (rrms). | 2016 | 26894206 |
| diffuse large b-cell lymphoma in colon confounded by prior history of colorectal cancer: a case report and literature review. | a 66-year-old male underwent left hemicolectomy for rectal adenocarcinoma in 2008. five years later he was admitted to hospital with abdominal pain. a computed tomography scan revealed notable thickening of the middle of the ascending colon wall, and colonoscopy revealed an ulcerofungating mass of 3×3 cm in the cecum and extending to the ascending colon. under the consideration of cancer recurrence, laparoscopic right hemicolectomy was performed directly. surgical specimens revealed sheets of la ... | 2016 | 26893766 |
| primary gastric natural killer/t-cell lymphoma with diffuse cd30 expression and without cd56 expression: a case report. | the majority of natural killer (nk)/t-cell lymphomas occur in the nasal cavity and rarely involve the stomach. they possess a specific immunophenotype, with the expression of cluster of differentiation (cd)56, cd2 and cd3ε, but without cd3 expression. few cases of nk/t-cell lymphoma have partial cd30 expression. the present study reveals a unique case of a 41-year-old female patient with gastric nk/t-cell lymphoma that did not express cd56 and diffusely expressed cd30. immunohistochemical staini ... | 2016 | 26893677 |
| question 2: does amoxicillin exposure increase the risk of rash in children with acute epstein-barr virus infection? | 2016 | 26893522 | |
| natural killer/t cell lymphoma, nasal type: a retrospective clinical analysis in north-western china. | extranodal natural killer (nk)/t cell lymphoma (enktl) is an aggressive non-hodgkin's lymphoma with high mortality and poor prognosis despite radiotherapy and chemotherapy. the current analysis aimed to assess the pathological features, clinical features, and prognostic indicators of enktl. | 2016 | 26891121 |
| highly efficient crispr/cas9-mediated cloning and functional characterization of gastric cancer-derived epstein-barr virus strains. | the epstein-barr virus (ebv) is etiologically linked to approximately 10% of gastric cancers, in which viral genomes are maintained as multicopy episomes. ebv-positive gastric cancer cells are incompetent for progeny virus production, making viral dna cloning extremely difficult. here we describe a highly efficient strategy for obtaining bacterial artificial chromosome (bac) clones of ebv episomes by utilizing a crispr/cas9-mediated strand break of the viral genome and subsequent homology-direct ... | 2016 | 26889033 |
| kinetics of epstein-barr virus (ebv) neutralizing and virus-specific antibodies after primary infection with ebv. | prospective studies of antibodies to multiple epstein-barr virus (ebv) proteins and ebv neutralizing antibodies in the same individuals before, during, and after primary ebv infection have not been reported. we studied antibody responses to ebv in college students who acquired primary ebv infection during prospective surveillance and correlated the kinetics of antibody response with the severity of disease. neutralizing antibodies and enzyme-linked immunosorbent assay (elisa) antibodies to gp350 ... | 2016 | 26888186 |
| rampant infections of bone marrow stem cell niches as triggers for spondyloarthropathies and rheumatoid arthritis. | tropheryma whipplei can induce rheumatism mimicking spa or ra, but even more rampant bacterial/viral infections in epiphyseal bones could also contribute to the onset of ra and spa. indeed, as bone marrow stem cell niches are enriched in tregs and myeloid derived suppressor cells, these areas are favourable for the persistence of quiescent viruses and/or dormant bacteria. this review focuses on the possibility that such silent infections of bone marrow stem cell niches might contribute to the pa ... | 2017 | 26886813 |
| epstein-barr virus-related posttransplant lymphoproliferative disorder in children: a single-institution experience. | we report 4 pediatric cases of biopsy-proven posttransplant lymphoproliferative disorder (ptld) in the context of allogeneic hematopoietic stem cell transplantation (hsct). all cases showed diffuse staining with latent membrane protein-1 in immunohistochemistry. the median age at transplant of 4 patients with ptld was 10.1 years (range, 2.2 to 13.2 y). the median interval between hsct and the diagnosis of ptld was 5.5 months (range, 4 to 8 mo). all patients were treated with rituximab at dosage ... | 2016 | 26886374 |
| another report of acalculous cholecystitis in a greek patient with infectious mononucleosis: a matter of luck or genetic predisposition? | we here report a case of a young, male patient who presented with jaundice and was diagnosed with acalculous cholecystitis during the course of a primary epstein-barr virus (ebv) infection. the coexistence of cholestatic hepatitis and acalculous cholecystitis in patients with infectious mononucleosis is extremely uncommon and only few cases can be found in the literature. moreover, almost one-fourth of the total reports of this rare entity are coming from greece. whether this is a result of phys ... | 2016 | 26885417 |
| expression of ebv antibody ea-iga, rta-igg and vca-iga and sa in serum and the implication of combined assay in nasopharyngeal carcinoma diagnosis. | epstein-barr virus (ebv) is an important non-invasive index for nasopharyngeal carcinoma. serum sialic acid (sa) level was known to be related with tumor progression. rta protein antibody igg (rta-igg), early antigen antibody (ea-iga) and viral capsid antibody (vca-iga) levels in serum can also be used to effectively monitor the progression of cancer. this study investigated serum level of sa, rta-igg, ea-iga and vca-iga in nasopharyngeal cancer patients and the diagnostic value of combined assa ... | 2015 | 26884888 |
| prevalence and clinicopathologic features of cd30-positive de novo diffuse large b-cell lymphoma in chinese patients: a retrospective study of 232 cases. | diffuse large b-cell lymphoma (dlbcl) is a heterogeneous disease that great efforts had been made in to build up molecular and immunophenotypic subgroups that could relatively accurate indicate prognosis and give clue to therapy. recently, cd30 was reported as a useful predictor with favorable clinical outcome. however, cd30 expression patterns and the clinicopathologic features of cd30 positive dlbcl are not well described thus far, especially in asian patients. here, we studied 232 cases of de ... | 2015 | 26884853 |
| runx super-enhancer control through the notch pathway by epstein-barr virus transcription factors regulates b cell growth. | in b cells infected by the cancer-associated epstein-barr virus (ebv), runx3 and runx1 transcription is manipulated to control cell growth. the ebv-encoded ebna2 transcription factor (tf) activates runx3 transcription leading to runx3-mediated repression of the runx1 promoter and the relief of runx1-directed growth repression. we show that ebna2 activates runx3 through a specific element within a -97 kb super-enhancer in a manner dependent on the expression of the notch dna-binding partner rbp-j ... | 2016 | 26883634 |
| pretreatment whole blood epstein-barr virus-dna is a significant prognostic marker in patients with hodgkin lymphoma. | epstein-barr virus (ebv) in the peripheral blood has become a significant predictor of clinical outcomes in ebv-associated hodgkin lymphoma (hl). however, due to its relative rarity, prevalence and prognostic role of circulating ebv-dna has not been well established in asian patients. seventy patients with newly diagnosed hl were prospectively registered between october 2007 and january 2013, and underwent pretreatment whole blood (wb) ebv-dna quantitation using real-time polymerase chain reacti ... | 2016 | 26883027 |
| herpesvirus infections and transglutaminase type 2 antibody positivity in childhood: the generation r study. | persistent viral infections have been implicated in the etiology of autoimmune diseases in adulthood, but it is not known whether herpesviruses are associated with the development of celiac disease autoimmunity in childhood. we assessed whether herpesvirus infections are associated with transglutaminase type 2 antibody (tg2a) concentrations in children at 6 years of age. | 2016 | 26881413 |
| early relapse of severe chronic active epstein-barr virus infection with posterior reversible encephalopathy syndrome after reduced intensity stem cell transplantation with umbilical cord blood. | 2016 | 26879589 | |
| [clinicopathologic characteristics and immunophenotypes of histiocytic necrotizing lymphadenitis: an analysis of 84 cases]. | to study the clinical manifestation, pathologic features and immunophenotype of histiocytic necrotizing lymphadenitis (hnl). | 2016 | 26879428 |
| [diffuse large b-cell lymphoma with aberrant expression of cd56: a clinicopathologic and immunohistochemical study]. | to study the clinicopathologic features and significance of aberrant cd56 expression in diffuse large b-cell lymphoma (dlbcl). | 2016 | 26879426 |
| targeted disruption of ebna1 in ebv-infected cells attenuated cell growth. | epstein barr virus (ebv)-encoded nuclear antigen-1 (ebna1) plays a pivotal in an ebv episome replication and persistence. despite considerable attempts, there are no ebv drugs or vaccines. we attempted to eradicate ebv episomes by targeting ebna1 using the transcription activator-like effector nucleases (talen) (e1tn). e1tn-mediated transient knockout (ko) of ebna1 reduced ebna1 expression, and caused significant loss of ebv genomes and progressive death of ebv-infected cells. furthermore, when ... | 2016 | 26879316 |
| nonsteroidal anti-inflammatory drugs quickly resolve symptoms associated with ebv-induced infectious mononucleosis in patients with atopic predispositions. | infectious mononucleosis is a clinical syndrome most commonly associated with primary epstein-barr virus (ebv) infection. in adults, the symptoms can often be severe and prolonged, sometimes causing serious complications. analgesic or antipyretic drugs are normally used to relieve the symptoms. however, there is no causal treatment for the disease. | 2016 | 26874639 |
| a prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis. | the clinical outcome of extranodal natural killer t-cell lymphoma (enktl) has improved substantially as a result of new treatment strategies with non-anthracycline-based chemotherapies and upfront use of concurrent chemoradiotherapy or radiotherapy. a new prognostic model based on the outcomes obtained with these contemporary treatments was warranted. | 2016 | 26873565 |
| the role of tumour-infiltrating eosinophils, mast cells and macrophages in classical and nodular lymphocyte predominant hodgkin lymphoma in children. | to study hodgkin lymphoma (hl) microenvironment in a swedish paediatric population and its relation to clinical parameters. | 2016 | 26872637 |
| development of an ifnγ elispot for the analysis of the human t cell response against mumps virus. | in the last decade, mumps virus (muv) causes outbreaks in highly vaccinated populations. sub-optimal t cell immunity may play a role in the susceptibility to mumps in vaccinated individuals. t cell responses to mumps virus have been demonstrated, yet the quality of the muv-specific t cell response has not been analyzed using single cell immunological techniques. here we developed an ifnγ elispot assay to assess muv-specific t cell responses in peripheral blood mononuclear cells (pbmc) of healthy ... | 2016 | 26872407 |
| extranodal nk/t-cell lymphoma, nasal type of the uterine cervix: a case report. | we report a rare case of extranodal nk/t-cell lymphoma, nasal type of the uterine cervix that showed cytologic features mimicking cervical cancer. a 65-year-old woman presented with vaginal bleeding. gynecological examination revealed a bulky tumor of the cervix. a conventional papanicolaou-stained cervical smear showed hypercellularity consisting of numerous variably sized cohesive clusters that mimicked epithelial tumors, with a necrotic and inflammatory background. a small number of individua ... | 2016 | 26872300 |
| detection of epstein-barr virus dna in langerhans cell histiocytosis. | langerhans cell histiocytosis (lch) is a rare histiocytic proliferation of unknown etiology. it is characterized by granuloma-like proliferation of langerhans-type dendritic cells and mainly affects young children. although multiple investigators have suggested the possible role of viruses, such as epstein-barr virus (ebv), human herpesvirus-6 (hhv-6), herpes simplex virus (hsv) types 1 and 2, and cytomegalovirus (cmv) in the pathogenesis of lch, it remains, however, debated. | 2015 | 26870310 |
| expression of epstein-barr virus-induced gene 3 in cervical cancer: association with clinicopathological parameters and prognosis. | epstein-barr virus-induced gene 3 (ebi3) encodes a secretory glycoprotein, and has previously been identified as upregulated in a series of cancers. however, the clinical significance of ebi3 in cervical cancer and the potential of ebi3 as a therapeutic target for this disease have not been elucidated. in the present study, ebi3 expression was analyzed by immunohistochemistry in 90 clinicopathologically characterized cervical cancer tissue samples. the association between ebi3 expression and sur ... | 2016 | 26870212 |
| primary cutaneous anaplastic large-cell lymphoma with 6p25.3 rearrangement in a cardiac transplant recipient: a case report and review of the literature. | posttransplant lymphoproliferative disorders define an important form of lymphoproliferative disease causally linked with a state of iatrogenic immune dysregulation inherent to the posttransplant setting. most posttransplant lymphoproliferative disorders are in the context of epstein-barr virus-associated b-cell lymphoproliferative disease, most notably diffuse large-cell b-cell lymphoma. a less common variant falls under the rubric of posttransplant t-cell lymphoproliferative disease, which is ... | 2016 | 26863058 |
| historical review of the causes of cancer. | in the early 1900s, numerous seminal publications reported that high rates of cancer occurred in certain occupations. during this period, work with infectious agents produced only meager results which seemed irrelevant to humans. then in the 1980s ground breaking evidence began to emerge that a variety of viruses also cause cancer in humans. there is now sufficient evidence of carcinogenicity in humans for human t-cell lymphotrophic virus, human immunodeficiency virus, hepatitis b virus, hepatit ... | 2016 | 26862491 |
| epstein- barr virus: clinical and epidemiological revisits and genetic basis of oncogenesis. | epstein-barr virus (ebv) is classified as a member in the order herpesvirales, family herpesviridae, subfamily gammaherpesvirinae and the genus lymphocytovirus. the virus is an exclusively human pathogen and thus also termed as human herpesvirus 4 (hhv4). it was the first oncogenic virus recognized and has been incriminated in the causation of tumors of both lymphatic and epithelial nature. it was reported in some previous studies that 95% of the population worldwide are serologically positive t ... | 2015 | 26862355 |
| zosteriform staphylococcus aureus cutaneous infection: report of two patients with dermatomal bacterial infection. | the aim of this study was to describe cutaneous infections, which are zosteriform in distribution, including two patients with dermatomal staphylococcus aureus infection. herpes zoster infectious lesions usually occur in a dermatomal distribution. other viruses, such as herpes simplex virus, can also appear with zosteriform lesions and closely mimic the clinical presentation of herpes zoster. additionally, other skin infections, less commonly, are zosteriform. two patients who developed zosterif ... | 2016 | 26861424 |
| [immunodeficiency-associated burkitt lymphoma developed in a patient receiving a long-term methotrexate therapy for rheumatoid arthritis]. | an increased risk of lymphoproliferative disorders (lpd) has been demonstrated in patients treated with methotrexate (mtx) for rheumatoid arthritis (ra). the role of epstein-barr virus (ebv) has been discussed in the pathogenesis of immunodeficiency-associated lpds. we herein present a ra patient, who developed burkitt lymphoma during mtx treatment. the patient was a 61-year-old japanese female with a 10-year history of weekly mtx therapy for ra. she presented with a one-month history of submand ... | 2016 | 26861097 |
| [pathogenesis and novel therapy for ebv-related b-cell lymphoma]. | epstein-barr virus (ebv), a type of γ-herpes virus, is known to be a tumor virus. about 90% of adults were found to be persistently infected with ebv and this infection is responsible for burkitt lymphoma (bl), extranodal nk/t cell lymphoma, hodgkin lymphoma (hl), acquired immune deficiency syndrome (aids)-associated lymphoma, and a portion of diffuse large b cell lymphomas (dlbcl). ebv-positive dlbcl in the elderly, a disease recognized in japan, is described in the who classification as a new ... | 2016 | 26861096 |
| epstein-barr virus infection in gastric remnant carcinoma and recurrent gastric carcinoma in qingdao of northern china. | epstein-barr virus (ebv) is associated with a subset of gastric carcinoma which was defined as ebv associated gastric carcinoma (ebvagc). the proportion of ebvagc in gastric remnant carcinoma (grc) which occurs in the intact stomach five or more years after gastric surgery for benign disease is significantly higher than that in conventional gastric carcinoma (cgc). the infection of ebv in recurrent gastric carcinoma (rgc) with local anastomotic recurrence is poorly understood. | 2016 | 26859565 |
| the role of biologicals in intestinal transplantation. | this article reviews the role of biologicals in intestinal transplantation. | 2016 | 26859221 |
| plasmacytoma-like posttransplant lymphoproliferative disorder in a pediatric heart transplant recipient. | posttransplant lymphoproliferative disorder (ptld) is a diversely manifesting group of lymphoid or plasmacytic proliferations found in solid organ and bone marrow transplant recipients. ptld occurs as a result of immunosuppression and is often driven by the epstein barr virus. although most commonly of b-cell origin, similar to b-cell lymphomas, ptld can rarely present as a plasmacytic process, resembling multiple myeloma. although more common in adults, 8 cases of plasmacytoma-like ptld have be ... | 2016 | 26859193 |
| ribosome protein l4 is essential for epstein-barr virus nuclear antigen 1 function. | epstein-barr virus (ebv) nuclear antigen 1 (ebna1)-mediated origin of plasmid replication (orip) dna episome maintenance is essential for ebv-mediated tumorigenesis. we have now found that ebna1 binds to ribosome protein l4 (rpl4). rpl4 shrna knockdown decreased ebna1 activation of an orip luciferase reporter, ebna1 dna binding in lymphoblastoid cell lines, and ebv genome number per lymphoblastoid cell line. ebv infection increased rpl4 expression and redistributed rpl4 to cell nuclei. rpl4 and ... | 2016 | 26858444 |
| cervical lymphadenopathies in children: a prospective clinical cohort study. | cervical lymphadenopathy (lap) is a common sign and may raise fears about serious illnesses. the aim of our study was to evaluate the patients with cervical laps in a general pediatrics clinic setting, and to evaluate follow-up results for potential causes and risk factors for malignancies. | 2016 | 26857321 |
| sudden sensorineural hearing loss in children: etiology, management, and outcome. | pediatric sudden sensorineural hearing loss (ssnhl) is uncommon, and the current guidelines for its management refer to adults. our objective was to review cases of ssnhl in children and examine their etiologies, management, and outcome. | 2016 | 26857312 |
| primary intraventricular leiomyoma in an immunocompetent patient: first case report and review of the literature. | primary intracranial leiomyoma is an extremely rare occurrence of a low-grade mesenchymal tumor characterized by a proliferation of smooth muscle cells. when present, these lesions predominantly occur in immunocompromised patients in the setting of infection or transplant and have not been known to involve the ventricular system of the brain. in this report, we describe a case of primary leiomyoma of the lateral ventricle in an immunocompetent patient. | 2016 | 26855311 |
| dihydro-β-agarofuran sesquiterpenes from celastraceae species as anti-tumour-promoting agents: structure-activity relationship. | inhibition of tumour promotion in multistage chemical carcinogenesis is considered a promising strategy for cancer chemoprevention. in an ongoing investigation of bioactive secondary metabolites from celastraceae species, five new dihydro-β-agarofuran sesquiterpenes (1-5), named chiapens a-e, and seventeen known ones, were isolated from maytenus chiapensis. their structures were elucidated by extensive nmr spectroscopic and mass spectrometric techniques, and their absolute configurations were de ... | 2016 | 26854381 |
| mir-1, regulated by lmp1, suppresses tumour growth and metastasis by targeting k-ras in nasopharyngeal carcinoma. | there is evidence to show that downregulation of mir-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (npc). however, the molecular mechanisms underlying mir-1 downregulation in npc remain largely unknown, especially its association with epstein-barr virus (ebv). in this study we found that restoration of mir-1 dramatically inhibited cell invasion in vitro, together with tumour growth and metastasis in vivo. importantly, we found that lmp1, an epstein- ... | 2015 | 26852690 |
| unusual presentation of epstein-barr virus-positive diffuse large b-cell non-hodgkin lymphoma of the elderly. | this report describes the case of a 76-year-old woman diagnosed with epstein-barr virus-positive diffuse large b-cell non-hodgkin lymphoma of the elderly. she had an unusual presentation of the disease with widespread skeletal muscle, masticatory muscle, and parotid gland involvement and the development of interesting erythematous lesions in the neck during chemotherapy. one month after completion of chemotherapy, positron-emission tomography (pet) showed features of persistent lymphoma, but a r ... | 2016 | 26850867 |
| gh/gl supercomplexes at early stages of herpesvirus entry. | membrane fusion during herpesvirus entry into host cells is a complex process where multiple glycoproteins interact to relay the triggering signal from a receptor-binding protein to the conserved fusogen gb through the conserved heterodimer gh/gl. crystal structures of individual glycoproteins are available, yet high-order 'supercomplexes' have been elusive. recent structures of complexes between gh/gl from human cytomegalovirus or epstein-barr virus and the receptor-binding proteins that form a ... | 2016 | 26849495 |
| identifying patient-specific epstein-barr nuclear antigen-1 genetic variation and potential autoreactive targets relevant to multiple sclerosis pathogenesis. | epstein-barr virus (ebv) infection represents a major environmental risk factor for multiple sclerosis (ms), with evidence of selective expansion of epstein-barr nuclear antigen-1 (ebna1)-specific cd4+ t cells that cross-recognize ms-associated myelin antigens in ms patients. hla-drb1*15-restricted antigen presentation also appears to determine susceptibility given its role as a dominant risk allele. in this study, we have utilised standard and next-generation sequencing techniques to investigat ... | 2016 | 26849221 |
| constitutively active mavs inhibits hiv-1 replication via type i interferon secretion and induction of hiv-1 restriction factors. | type i interferon is known to inhibit hiv-1 replication through the induction of interferon stimulated genes (isg), including a number of hiv-1 restriction factors. to better understand interferon-mediated hiv-1 restriction, we constructed a constitutively active form of the rig-i adapter protein mavs. constitutive mavs was generated by fusion of full length mavs to a truncated form of the epstein barr virus protein lmp1 (δlmp1). supernatant from δlmp1-mavs-transfected 293t cells contained high ... | 2016 | 26849062 |
| reduced mitochondrial function in human huntington disease lymphoblasts is not due to alterations in cardiolipin metabolism or mitochondrial supercomplex assembly. | huntington's disease (hd) is an autosomal dominant disease that occurs as a result of expansion of the trinucleotide repeat cag (glutamine) on the htt gene. hd patients exhibit various forms of mitochondrial dysfunction within neurons and peripheral tissues. cardiolipin (ptd2gro) is a polyglycerophospholipid found exclusively in mitochondria and is important for maintaining mitochondrial function. we examined if altered ptd2gro metabolism was involved in the mitochondrial dysfunction associated ... | 2016 | 26846325 |
| bs69/zmynd11 c-terminal domains bind and inhibit ebna2. | epstein-barr virus (ebv) nuclear antigen 2 (ebna2) plays an important role in driving immortalization of ebv-infected b cells through regulating the expression of many viral and cellular genes. we report a structural study of the tumor suppressor bs69/zmynd11 c-terminal region, comprised of tandem coiled-coil-mynd domains (bs69cc-mynd), in complex with an ebna2 peptide containing a pxlxp motif. the coiled-coil domain of bs69 self-associates to bring two separate mynd domains in close proximity, ... | 2016 | 26845565 |
| intralymphatic proliferation of t-cell lymphoid blasts in the setting of hidradenitis suppurativa. | intralymphatic proliferation of t-cell lymphoid blasts (iptclbs) is a rare, recently described entity, associated with cutaneous inflammatory conditions and characterized by intralymphatic proliferation of highly proliferating, blastoid t lymphocytes expressing cd30, thus mimicking an intravascular lymphoma. in all reported cases, the intralymphatic proliferation was associated with an underlying inflammatory condition, with no clonal t-cell receptor rearrangement, no signs of systemic or cutane ... | 2016 | 26844617 |
| epstein-barr virus-positive t/nk-cell lymphoproliferative disorders manifested as gastrointestinal perforations and skin lesions: a case report. | systemic epstein-barr virus (ebv)-positive t-cell lymphoproliferative disorders (lpds) of childhood is a highly aggressive ebv-positive t/natural killer (nk)-cell lpd, which emerges in the background of chronic active ebv infection (caebv) or shortly after primary acute ebv infection. the clinical presentations of caebv are varied; patients with atypical manifestations are easily misdiagnosed. we described a 14-year-old boy suffering from digestive disorders and intermittent fever for 1 year and ... | 2016 | 26844502 |
| prognostic value of plasma epstein-barr virus dna for local and regionally advanced nasopharyngeal carcinoma treated with cisplatin-based concurrent chemoradiotherapy in intensity-modulated radiotherapy era. | this study aimed to evaluate the prognostic value of plasma epstein-barr virus dna (ebv dna) for local and regionally advanced nasopharyngeal carcinoma (npc) patients treated with concurrent chemoradiotherapy in intensity-modulated radiotherapy (imrt) era.in this observational study, 404 nonmetastatic local and regionally advanced npc patients treated with imrt and cisplatin-based concurrent chemotherapy were recruited. blood samples were collected before treatment for examination of plasma ebv ... | 2016 | 26844482 |
| quantitative pcr for plasma epstein-barr virus loads in cancer diagnostics. | epstein-barr virus (ebv) is the causative agent of infectious mononucleosis and is associated with posttransplant lymphoproliferative disease (ptld), hodgkin's lymphoma, burkitt's lymphoma, nasopharyngeal carcinoma, and hiv-related lymphomas. it infects nearly all humans and then persists for the life of the host in a small proportion of benign b lymphocytes. ebv reactivation, usually in the setting of immunosuppression, is the main risk factor for development of ebv-associated malignancies. ebv ... | 2016 | 26843046 |
| replication of human herpesviruses is associated with higher hiv dna levels during antiretroviral therapy started at early phases of hiv infection. | asymptomatic replication of human herpesviruses (hhv) is frequent in hiv-infected men and is associated with increased t-cell activation and hiv disease progression. we hypothesized that the presence of replication of cytomegalovirus (cmv) and epstein-barr virus (ebv) (the most frequently detected hhv) might influence hiv dna decay during antiretroviral therapy (art). we investigated 607 peripheral blood mononuclear cell (pbmc) samples from 107 cmv-seropositive, hiv-infected men who have sex wit ... | 2016 | 26842469 |
| transient seizure-related mri abnormalities in a child with primary epstein-barr virus infection. | we describe the case of a 6-year-old girl with typical infectious mononucleosis syndrome complicated by clustered right hemiconvulsions and disturbed consciousness. diffusion-weighted magnetic resonance imaging on admission demonstrated reduced diffusion in the left temporo-posterior cortex and pulvinar of the ipsilateral thalamus. her neurological symptoms resolved completely by the next day, with complete disappearance of abnormal signal intensities on magnetic resonance imaging (mri). elevate ... | 2016 | 26842344 |
| risk stratification based on change in plasma epstein-barr virus dna load after treatment in nasopharyngeal carcinoma. | nasopharyngeal carcinoma is associated with epstein-barr virus (ebv). the current study investigated change in the plasma ebv dna load in the first 3 months after treatment and its clinical significance in npc. | 2016 | 26840023 |
| correction: human leukocyte antigen (hla) a*1101-restricted epstein-barr virus-specific t-cell receptor gene transfer to target nasopharyngeal carcinoma. | 2016 | 26839310 | |
| diagnosis of burkitt lymphoma and related high-grade b-cell neoplasms. | burkitt lymphoma (bl) is an aggressive b-cell neoplasm with an extremely short doubling time that mainly affects children and young adults. despite having several characteristic features, none is entirely specific for bl and the differential diagnosis may include diffuse large b-cell lymphoma (dlbcl), b lymphoblastic leukemia/lymphoma, and b-cell lymphoma unclassifiable with features intermediate between dlbcl and bl. we outline a practical approach to establish a diagnosis of bl and distinguish ... | 2010 | 26839298 |
| herpesvirus-associated b-cell proliferations. | this article reviews the spectrum of epstein-barr virus and kaposi sarcoma herpesvirus (kshv/hhv-8)-associated b-cell lymphoid proliferations, their pathologic features and clinical presentation, diagnostic criteria, and pathogenetic aspects. emphasis is on the differential diagnosis issues and difficulties that the pathologist may face for the correct identification and interpretation of these lesions. | 2010 | 26839297 |
| liver transplant pathology: review of challenging diagnostic situations. | histopathologic assessment of allograft liver biopsies has an important role in managing patients who have undergone liver transplantation. in this review, several topics are discussed that create diagnostic problems in transplant pathology, with emphasis on pathologic features and differential diagnosis. the topics discussed are acute cellular rejection, late acute rejection (centrizonal/parenchymal rejection), chronic rejection, plasma cell hepatitis, idiopathic posttransplant chronic hepatiti ... | 2013 | 26838975 |
| acute ebv masquerading as peripheral t-cell lymphoma. | histological features of epstein-barr virus (ebv) can rarely mimic lymphoma. a 25-year-old presented with a spontaneous splenic rupture following a short illness. histopathology assessment of the splenic and marrow tissue was highly suggestive of peripheral t-cell lymphoma not-otherwise-specified (ptcl-nos). t-cell receptor (tcr) pcr clonality studies revealed a monoclonal t-cell population expressing for both tcrβ and γ, strongly suggestive of a t-cell clonal disease. ebv igm was positive and i ... | 2016 | 26838300 |
| epstein-barr virus-associated diffuse large b-cell lymphoma: diagnosis, difficulties and therapeutic options. | epstein barr virus (ebv)-positive diffuse large b cell lymphoma (dlbcl) most frequently affects elderly patients, without previous immunosuppression, with frequent extra-nodal involvement and whose disease runs an aggressive clinical course with high international prognostic index (ipi) scores. various ebv-related transforming mechanisms, much favored by immunosenescence, have been described, including activation of the nfkb transcriptional program. elderly patients show poor survival after trea ... | 2016 | 26838128 |
| mild form of guillain-barré syndrome in a patient with primary epstein-barr virus infection. | 2016 | 26837010 | |
| high-density peptide microarray analysis of igg autoantibody reactivities in serum and cerebrospinal fluid of multiple sclerosis patients. | intrathecal immunoglobulin g (igg) synthesis and oligoclonal igg bands in cerebrospinal fluid (csf) are hallmarks of multiple sclerosis (ms), but the antigen specificities remain enigmatic. our study is the first investigating the autoantibody repertoire in paired serum and csf samples from patients with relapsing-remitting ms (rrms), primary progressive ms (ppms), and other neurological diseases by the use of high-density peptide microarrays. protein sequences of 45 presumed ms autoantigens (e. ... | 2016 | 26831522 |
| intratonsillar metastasis of ebv-positive nasopharyngeal carcinoma. | we present the case of a 47-year-old man with a history of epstein-barr-virus-positive nasopharyngeal carcino- ma who developed a metastasis to the palatine tonsil. to the best of our knowledge, this is the first reported case of an intratonsillar metastasis of a nasopharyngeal carcinoma. the aim of this report is to emphasize the importance of vigilant surveillance in patients with nasopharyngeal carcinoma. this case also demonstrates that an atypical metastatic pattern can raise suspicion of a ... | 2016 | 26829691 |
| prevalence of salivary epstein-barr virus in potentially malignant oral disorders and oral squamous cell carcinoma. | to analyze the presence of salivary epstein-barr virus (ebv) dna in oral squamous cell carcinoma and potentially malignant oral disorders. | 2016 | 26827058 |
| relationship of long noncoding rna and viruses. | long noncoding (lnc)rnas comprise a diverse group of transcripts including large intervening noncoding (linc)rnas, natural antisense transcripts (nats) and intronic lncrnas. the functions and mechanisms of more than 200 lncrnas have been studied in vitro and the results suggest that lncrnas may be molecular markers of prognosis in cancer patients. some lncrnas can promote virus replication and allow escape from cytosolic surveillance to suppress antiviral immunity. for example, lncrna can cause ... | 2016 | 26826341 |
| t-cell libraries allow simple parallel generation of multiple peptide-specific human t-cell clones. | isolation of peptide-specific t-cell clones is highly desirable for determining the role of t-cells in human disease, as well as for the development of therapies and diagnostics. however, generation of monoclonal t-cells with the required specificity is challenging and time-consuming. here we describe a library-based strategy for the simple parallel detection and isolation of multiple peptide-specific human t-cell clones from cd8(+) or cd4(+) polyclonal t-cell populations. t-cells were first amp ... | 2016 | 26826277 |
| extranodal nk/t-cell lymphoma, nasal type, presenting as a breast mass. | extranodal natural killer/t-cell lymphoma, nasal type, is a rare type of non-hodgkin cell lymphoma endemic to east asia and parts of central and south america. in most cases, it is driven by epstein-barr virus infections, with a broad range of morphologic appearances, frequent necrosis, and angioinvasion. it is designated as nk/t reflecting uncertainty in its cellular origins. these tumors usually arise in the nasal region, typically presenting with symptoms of nasal obstruction, epistaxis, and/ ... | 2015 | 26824008 |
| viral infections of the central nervous system in elderly patients: a retrospective study. | very few data exist on viral meningitis and encephalitis in elderly patients (>65 years old). | 2016 | 26820759 |
| genome-wide analysis of epstein-barr virus (ebv) integration and strain in c666-1 and raji cells. | ebv is a key risk factor for many malignancy diseases such as nasopharyngeal carcinoma (npc) and burkitt lymphoma (bl). ebv integration has been reported, but its scale and impact to cancer development is remains unclear. c666-1 (npc cell line) and raji (bl cell line) are commonly studied ebv-positive cancer cells. a rare few ebv integration sites in raji were found in previous research by traditional methods. to deeply survey ebv integration, we sequenced c666-1 and raji whole genomes by the ne ... | 2016 | 26819646 |
| pan-cancer immunogenomic perspective on the tumor microenvironment based on pd-l1 and cd8 t-cell infiltration. | there is currently no reliable biomarker to predict who would benefit from anti-pd-1/pd-l1 inhibitors. we comprehensively analyzed the immunogenomic properties in the cancer genome atlas (tcga) according to the classification of tumor into four groups based on pd-l1 status and tumor-infiltrating lymphocyte recruitment (til), a combination that has been suggested to be a theoretically reliable biomarker of anti-pd-1/pd-l1 inhibitors. | 2016 | 26819449 |
| induction of epstein-barr virus oncoprotein lmp1 by transcription factors ap-2 and early b cell factor. | latent membrane protein 1 (lmp1) is a major oncogene essential for primary b cell transformation by epstein-barr virus (ebv). previous studies suggested that some transcription factors, such as pu.1, rbp-jκ, nf-κb, and stat, are involved in this expression, but the underlying mechanism is unclear. here, we identified binding sites for pax5, ap-2, and ebf in the proximal lmp1 promoter (ed-l1p). we first confirmed the significance of pu.1 and pou domain transcription factor binding for activation ... | 2016 | 26819314 |
| genetic loci for epstein-barr virus nuclear antigen-1 are associated with risk of multiple sclerosis. | infection with the epstein-barr virus (ebv) is associated with an increased risk of multiple sclerosis (ms). | 2016 | 26819262 |
| bone marrow manifestations in multicentric castleman disease. | this study aimed to document the morphological and immunophenotypic features, and describe the diagnostic features of bone marrow (bm) involvement in human herpes virus 8 multicentric castleman disease (hhv8-mcd). bm trephine biopsy (bmtb) specimens from 28 patients were revisited. samples were evaluated for expression of cd3, cd20, cd138, cd68r, glycophorin c, cd42b, hhv8-latency-associated nuclear antigen (lana1), epstein-barr virus-encoded small rna and light chains. presence of significant n ... | 2016 | 26817834 |
| primary extranodal natural killer/t-cell lymphoma of bronchus and lung: a case report and review of literature. | primary pulmonary non-hodgkin's lymphoma (nhl) is very rare. it represents less than 1% of all nhl, and 0.5-1% of all primary pulmonary malignancies. almost all cases of primary pulmonary nhl originate from b-cell lineage. we present a case of a 53-year-old man with primary extranodal nk/t-cell lymphoma of the bronchus and lung, presented progressive dyspnea caused by right lower lung consolidation, and pleural effusion. initial chest computed tomography suggested advanced lung cancer. bronchofi ... | 2016 | 26816549 |
| absence of human herpesvirus 6b detection in association with illness in children undergoing cancer chemotherapy. | the lymphotropic herpesviruses, cytomegalovirus (cmv), epstein-barr virus (ebv), and human herpesvirus 6b (hhv-6b) can reactivate and cause disease in organ transplant recipients; the contributions of hhv-6a and hhv-7 to disease are less certain. less is known about their pathogenic roles in children undergoing treatment for malignancies. children with newly diagnosed cancer were followed for 24 months. clinical information and blood samples were collected during routine visits and during acute ... | 2016 | 26815906 |
| herpesvirus infections and childhood arterial ischemic stroke: results of the vips study. | epidemiological studies demonstrate that childhood infections, including varicella zoster virus, are associated with an increased risk of arterial ischemic stroke (ais). other herpesviruses have been linked to childhood ais in case reports. we sought to determine whether herpesvirus infections, which are potentially treatable, increase the risk of childhood ais. | 2016 | 26813104 |
| exposure to perinatal infections and bipolar disorder: a systematic review. | bipolar disorder (bd) is a debilitating psychiatric disorder and a growing global public health issue. notwithstanding bd has been conceptualized as a neuroprogressive illness, there are some evidences to suggest a role for neurodevelopmental pathways in the patho-etiology of this disorder. evidences on the associations between perinatal infections and risk for bipolar disorder have been inconsistent across studies. here, we performed a systematic review of observational studies on the relations ... | 2016 | 26812921 |
| genomic and epigenomic heterogeneity in molecular subtypes of gastric cancer. | gastric cancer is a complex disease that is affected by multiple genetic and environmental factors. for the precise diagnosis and effective treatment of gastric cancer, the heterogeneity of the disease must be simplified; one way to achieve this is by dividing the disease into subgroups. toward this effort, recent advances in high-throughput sequencing technology have revealed four molecular subtypes of gastric cancer, which are classified as epstein-barr virus-positive, microsatellite instabili ... | 2016 | 26811657 |
| epstein-barr virus and multiple sclerosis. from evidence to therapeutic strategies. | multiple sclerosis is caused by a complex interaction between genetic predisposition and environmental factors. epstein-barr virus (ebv) is an environmental risk factor that is strongly related to multiple sclerosis (ms), since ebv seropositivity is linked to a significant risk of developing ms. ebv may be involved in the pathogenesis of the disease and it is possibly a prerequisite for the development of ms. ebv infection persists in b-cells during the lifetime of the host and can modulate thei ... | 2016 | 26810546 |
| [a case of severe chronic active epstein-barr virus infection with aplastic anemia and hepatitis]. | epstein-barr virus (ebv) causes various acute and chronic diseases. chronic active ebv infection (caebv) is characterized by infectious mononucleosis-like symptoms that persist for more than 6 months with high viral loads in peripheral blood and/or an unusual pattern of anti-ebv antibodies. severe caebv is associated with poor prognosis with severe symptoms, an extremely high ebv-related antibody titer, and hematologic complications that often include hemophagocytic lymphohistiocytosis. however, ... | 2016 | 26809631 |
| genital epstein barr virus is associated with higher prevalence and persistence of anal human papillomavirus in hiv-infected men on antiretroviral therapy. | epstein barr virus (ebv) and human papillomavirus (hpv) can co-exist in pharyngeal and cervical malignancies. however, the natural history and factors associated with persistent hpv infection among hiv-infected men who have sex with men (msm) are unclear. | 2016 | 26809559 |
| integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in ebv infected-b cells. | we sought to gain a better understanding of the low-dose ionizing radiation (ldir)-induced molecular changes in transformed pre-malignant cells in their microenvironment. | 2016 | 26809544 |
| a case of igg4-related lung disease complicated by asymptomatic chronic epstein-barr virus infection. | a 70-year-old male visited our hospital due to failure of pneumonia treatment. chest ct showed consolidation in the right middle field and slight mediastinal lymphadenopathy in the subcarinal region. lung consolidation improved with antibiotics; subcarinal lymphadenopathy progressed after four months. malignant lymphoma was suspected given elevated sil2-r levels (1862 u/ml). patchy ground glass opacities appeared in the bilateral lung field just before surgical biopsy. he was diagnosed with igg4 ... | 2016 | 26808729 |
| correction: elevated concentrations of serum immunoglobulin free light chains in systemic lupus erythematosus patients in relation to disease activity, inflammatory status, b cell activity and epstein-barr virus antibodies. | 2016 | 26808424 | |
| enhanced antitumor effect of combining chemotherapy with epstein-barr virus (ebv)-specific cytotoxic t lymphocytes in mice with ebv-related non-hodgkin's lymphoma. | epstein-barr virus (ebv)-related non-hodgkin's lymphoma (nhl) represents a major problem in hematological clinical studies due to its drug tolerance and refractoriness. ebv infection is a key factor driving the process of tumor growth. immune therapy is an important biotherapeutic method of treating cancer, which is attracting increasing attention. we hypothesized that combining conventional chemotherapy with immune therapy in the treatment of ebv-related nhl may achieve better outcomes. first, ... | 2015 | 26807226 |