Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| establishment of the cells useful for murine interleukin-18 bioassay by introducing murine interleukin-18 receptor cdna into human myelomonocytic kg-1 cells. | we genetically engineered human myelomonocytic kg-i cells by introducing cdna of murine interleukin-18 receptor (muil-18r) and established human cells which were capable of responding to muil-18. these cells expressed larger number of muil-18r (> 13,000 sites/cell) than intrinsic human il-18 receptor (huil-18r) (< 2,500 sites/cell). and the cells responded to muil-18 as well as to huil-18 in a dose-dependent manner, and produced large amounts of interferon-gamma (ifn-gamma). we could estimate th ... | 1998 | 9776579 |
| effect of vaccination and the immunomodulators "bacillus of calmette-guérin, avridine and propionibacterium acnes" on rabies in mice. | responses of vaccination and treatment to immunomodulators against rabies in mice were evaluated through macrophage inhibition factor (mif), intra-pad inoculation (ipi) and serum neutralization (sn) tests and by the detection of gamma-interferon (ifn-gamma). onco-bcg, avridine and propionibacterium acnes were administered to groups of mice. higher survival rates were found in animals treated with p. acnes. lower levels of ifn-gamma were observed in the groups of infected and vaccinated mice. the ... | 1998 | 9775360 |
| [effect of silymarin on mouse liver damage, production and activity of tumor necrosis factor]. | tumor necrosis factor (tnf) has been well-characterized as a prominent mediator in the development of liver injury. effects of silymarin (sb) on mouse liver damage, tnf production and activity were studied. pretreatment with sb (25-50 mg.kg-1, i.p., bid x 3 d) before the lipopolysaccharides (lps) injection markedly alleviated liver injury and diminished lps-induced tnf production in propionibacterium acnes (pa)-primed mice. sb (12.5-50 micrograms.ml-1) significantly inhibited lps-induced tnf rel ... | 1996 | 9772703 |
| systematic review of propionibacterium acnes resistance to systemic antibiotics. | to document changes in the prevalence of resistance of propionibacterium acnes to antibiotics used for treating acne. | 1998 | 9762064 |
| update on acne. | acne is a common condition seen routinely by both primary care physicians and dermatologists. most patients have no underlying pathology and respond to traditional treatment; others, however, require more individualized evaluation and aggressive therapy. new information regarding the pathogenesis and treatment of acne is now available. this update discusses the proper evaluation of early childhood acne, the emergence of propionibacterium acnes resistance, and the rare but serious side effects oc ... | 1998 | 9757362 |
| mechanism of suppressed neutrophil mobilization in a mouse model for binge drinking: role of glucocorticoids. | the goals of this study were to determine if suppression of neutrophil accumulation and tnf-alpha production in the peritoneal cavity occurs in mice exposed to a chemical stressor [ethanol (etoh)], to evaluate the role of etoh-induced increases in endogenous glucocorticoids in any such suppression, and to determine if decreased tumor necrosis factor-alpha (tnf-alpha) production is responsible for decreases in neutrophil accumulation in etoh-treated mice. an inflammatory response induced in the p ... | 1998 | 9756533 |
| propionibacterium [correction of proprionibacterium] acnes infections of cerebrospinal fluid shunts. | ventricular cerebrospinal fluid shunt infections with propionibacterium acnes are generally low-grade, indolent infections. typical presentations include gradual shunt malfunction, nausea, headache, malaise, and infrequently, fever. in all, 489 shunt procedures performed between january 1992 and december 1995, and in 15 of these cases p. acnes was subsequently cultured from reservoir taps or an intraoperative culture which was obtained when the existing shunt components were revised. six of thes ... | 1998 | 9753404 |
| surface enhanced raman spectroscopic monitor of p. acnes lipid hydrolysis in vitro. | surface enhanced raman spectroscopy (sers) at a silver microelectrode was used to monitor bacterial hydrolysis of triglycerides in lipid mixtures that model sebaceous gland secretions. mixtures of wax esters, squalene, triolein, and triisostearin were used as model skin secretions. the transformation was followed in vitro as changes in the sers caused by hydrolysis of triglyceride to fatty acid. the fatty acid was adsorbed as its carboxylate, which is readily identified by the characteristic ban ... | 1998 | 9741703 |
| superficial suppurative thrombophlebitis in children, caused by anaerobic bacteria. | the purpose of this study was to present the microbiology and clinical features of six children with superficial suppurative thrombophlebitis (sst) caused by anaerobic bacteria. | 1998 | 9722004 |
| [chronic postoperative endophthalmitis caused by propionibacterium acnes]. | there is a report of three cases of chronic postoperative endophthalmitis following cataract operations. in two patients there was proven propionibacterium acnes. there is presented a technique to obtain specimens for microbiological examination and an overview of clinical experience in treatment of the mentioned less common types of endophthalmitis. early surgical treatment as well as intraocular injection of vancomycin can help to restore a good visual acuity despite of longlasting inflammatio ... | 1998 | 9721491 |
| in vitro activity of hmr 3647 against anaerobic bacteria. | the aim of the present investigation was to determine the in vitro activity of hmr 3647 compared with other antimicrobial agents against anaerobic bacteria. the activity of hmr 3647 was determined against 342 clinical isolates of anaerobic bacteria by the agar dilution method and was compared with azithromycin, clarithromycin, roxithromycin, erythromycin, cefoxitin, imipenem, clindamycin and metronidazole. among the macrolides hmr 3647 and among the beta-lactams imipenem were the most active age ... | 1998 | 9720465 |
| hepatoprotective effect of propagermanium on corynebacterium parvum and lipopolysaccharide-induced liver injury in mice. | propagermanium is an organic germanium compound with immunopotentiating activity. we examined the hepatoprotective effect of propagermanium and its mechanism in an experimental animal model of acute liver injury induced with corynebacterium parvum (c. parvum) and lipopolysaccharide (lps) injection. oral pretreatment with propagermanium decreased alanine aminotransferase (alt) and aspartate aminotransferase (ast) activity in a dose-dependent manner. significant attenuation of alt and ast activity ... | 1998 | 9716110 |
| [bacterial colonization of conjunctiva with propionibacterium acnes before and after polyvidon iodine administration before intraocular interventions]. | propionibacterium acnes has been described as a causative agent of postoperative endophthalmitis. this gram-positive, immotile, non-spore-forming bacterium is highly pleomorphic and grows under conditions of low to no oxygen concentration. it is commonly found on the skin at the openings of sebaceous glands and on hairs. a near-symptomless postoperative endophthalmitis occurs particularly when propionibacteria are enclosed in the capsular bag. we investigated to what extent the number of p. acne ... | 1998 | 9703725 |
| improved detection of infection in hip replacements. a currently underestimated problem. | our aim was to determine if the detection rate of infection of total hip replacements could be improved by examining the removed prostheses. immediate transfer of prostheses to an anaerobic atmosphere, followed by mild ultrasonication to dislodge adherent bacteria, resulted in the culture of quantifiable numbers of bacteria, from 26 of the 120 implants examined. the same bacterial species were cultured by routine microbiological techniques from only five corresponding tissue samples. tissue remo ... | 1998 | 9699813 |
| pancreatic fluid collections: diagnostic and therapeutic implications of percutaneous drainage guided by ultrasound. | the aim of the present study is to assess the usefulness of biochemical and bacteriological analysis of the pancreatic fluid obtained at percutaneous drainage of pancreatic pseudocysts and abscesses guided by ultrasound. | 1998 | 9684149 |
| percutaneous suction aspiration and drainage for pyogenic spondylitis. | retrospective evaluation of results in 23 cases of early-stage pyogenic spondylitis treated with percutaneous suction aspiration and drainage. | 1998 | 9682317 |
| comparative in vitro activity of bay 12-8039 and five other antimicrobial agents against anaerobic bacteria. | the in vitro activity of bay 12-8039 against 360 anaerobic clinical isolates was determined by the agar dilution method and compared to that of five other antimicrobial agents. bay 12-8039 and imipenem were the most active agents tested. the following mic90 values were determined for bay 12-8039: peptostreptococcus spp. (50 isolates), 1 mg/l; propionibacterium acnes (30 isolates). 0.25 mg/l; clostridium perfringens (30 isolates), 0.5 mg/l; clostridium difficile (50 isolates), 2 mg/l; bacteroides ... | 1998 | 9665302 |
| subgingival microflora associated with nifedipine-induced gingival overgrowth. | the purpose of this study was to examine the composition of subgingival plaque of 140 periodontal lesions in 35 patients with cardiovascular disorders who were administered nifedipine and manifested nifedipine-induced gingival overgrowth (go). age was inversely associated with the go. plaque index and bleeding index showed a significant association with go, while nifedipine dosage and duration of nifedipine therapy were not found to be significant predictors of go. the gingival inflammation as e ... | 1998 | 9660335 |
| immunologic function in horses after non-specific immunostimulant administration. | inactivated propionibacterium acnes is a biologic response modifier for treatment of non-specific respiratory disease in horses. the objectives of this investigation were to determine alterations in phagocytic activity, phenotypic expression of lymphocyte subpopulations and lymphokine-activated killing cell response in healthy young horses. samples were collected on day 0, 7 and 14 of the investigation. blood samples were obtained via jugular venipuncture and pulmonary leukocytes were recovered ... | 1998 | 9656421 |
| microbiology of cervical lymphadenitis in adults. | the microbiology of needle aspirates from 40 inflamed cervical lymph glands was studied for aerobic and anaerobic bacteria, fungi and mycobacteria. forty-two bacterial, 11 mycobacterial and six fungal isolates were isolated. aerobic bacteria only were recovered in 11 (27.5%), anaerobes alone in five (12.5%) and mixed aerobic and anaerobic bacteria in seven (17.5%). mycobacterium sp. were recovered in 11 (27.5%) and fungi in six (15%). the recovery of anaerobes was associated with dental infectio ... | 1998 | 9655225 |
| aerobic and anaerobic microbiology of chronic venous ulcers. | the role of bacteria in the pathogenesis of chronic venous leg ulcers (cvlu) is unclear. the objective of the study was to establish the aerobic and anaerobic bacteriology of cvlu. | 1998 | 9646126 |
| corynebacterium parvum pleurodesis and survival is not significantly influenced by pleural ph and glucose level. | this study was carried out in the pulmonary department of a referral training hospital for thoracic medicine and surgery, with the aim of assessing the effects of ph and glucose level of a pleural effusion (pe) on survival and the response to pleurodesis (pd) with corynebacterium parvum. a prospective study was carried out in 204 patients with recurrent, symptomatic pes (73 benign, 131 malignant). fifty eight per cent of 204 pes had low ph (< 7.20; 7.01 +/- 0.14) nd glucose levels (< 60 mg.dl-1; ... | 1998 | 9632902 |
| contribution of cd14 to endotoxin-induced liver injury may depend on types of macrophage activation in rats. | activated kupffer cells and hepatic macrophages can produce massive liver necrosis through microcirculatory disturbance due to sinusoidal fibrin deposition. this mechanism is involved in the development of liver injury after endotoxin administration in rats pretreated with heat-killed propionibacterium acnes (p.acnes) or undergoing 70% liver resection. the significance of cd14, a receptor for lipopolysaccharide and its binding protein, was evaluated in both models in relation to the activation m ... | 1998 | 9618280 |
| nosocomial diskitis due to propionibacterium acnes. | 1998 | 9617690 | |
| [therapeutic possibilities for acne vulgaris]. | 1998 | 9617104 | |
| kupffer cell activation with bcg. corynebacterium parvum or zymosan protects against acute liver injury induced by carbon tetrachloride in rats. | kupffer cells have been implicated in the pathogenesis of liver injury, but there is controversy about the effects of activation of these cells on the hepatotoxicity of chemicals and endotoxin. it has been shown that injection of corynebacterium parvum in rats induces macrophage activation that protects against toxic effects of carbon tetrachloride and acetaminophen, five days after injection, and this protection is due to inhibition of microsomal oxidizing enzymes and increased production of gl ... | 1997 | 9611293 |
| [fundamental studies on antibacterial activity of clindamycin against propionibacterium acnes]. | antibacterial activity of clindamycin against propionibacterium acnes (p. acnes) was evaluated in comparison with nadifloxacin in vitro. using a burned-infected mouse model, topical application of 1% gel form of clindamycin phosphate on p. acnes was also evaluated in in vivo. (1) the mic of clindamycin measured by agar dilution method was 0.02 microgram/ml, and this value was smaller than that of nadifloxacin (0.3 microgram/ml). (2) at concentrations on 1-, 2- and 4- times the mic clindamycin de ... | 1998 | 9575439 |
| systemic antibiotics for acne. | antibiotic therapy for acne is very common. antibiotics are frequently used in acne, either systemically or topically. systemic antibiotics are indicated as treatment of moderate and quite severe acne or if acne is considered as very serious by the patient for psychological or social reasons. results are very often excellent, but failure is possible; in this case using another treatment, especially isotretinoin, is necessary. a few antibiotics are useful: tetracyclines (tetracycline, doxycycline ... | 1998 | 9557248 |
| an overview of topical antibiotics for acne treatment. | topical use of antibiotics is currently a widely accepted effective and safe treatment for acne. a review of the articles published in the past 30 years revealed that topical application of antibiotics such as erythromycin, clindamycin or tetracycline showed clinical effectiveness for mild to moderate inflammatory acne, especially when they are combined with zinc, tretinoin or benzoyl peroxide, while they showed little influence on noninflammatory acne. the main mechanism of action of topical an ... | 1998 | 9557247 |
| topical drug treatment in acne. | the main part of acne treatment uses the topical route. more than 50% of acne patients belong to the group presenting with acne comedonica and papulopustulosa. whenever small nodes or scarring occur, systemic comedication is indicated, however. topical treatment affects at least three of the four main pathogenetic factors responsible for the development of acne, i.e. hyperseborrhea, hyperkeratosis, microbial colonization and inflammation. the agents currently available influence at least one of ... | 1998 | 9557245 |
| the possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation. | the purpose of this study was to investigate the possible role of reactive oxygen species (ros) generated by neutrophils in mediating acne inflammation. antibiotics used for the treatment of acne significantly inhibited ros generated by neutrophils, when compared to other antibiotics. metronidazole, which is effective in the treatment of acne, markedly inhibited ros generated by neutrophils. the drug is known to have no significant effect on the growth of propionibacterium acnes. the proportion ... | 1998 | 9557235 |
| inflammatory acne represents hypersensitivity to propionibacterium acnes. | hypersensitivity to p. acnes may account for the great variation in acne severity. alternative explanations such as hyperandrogenism fail to account for disease severity in large numbers of patients. | 1998 | 9557234 |
| resistance to erythromycin and clindamycin in cutaneous propionibacteria is associated with mutations in 23s rrna. | 1998 | 9557230 | |
| propionibacterium acnes and acne. | 1998 | 9557229 | |
| bacterial resistance in acne. | antibiotics play a major role in acne therapy. physicians base treatment choices on personal perceptions of efficacy, cost-effectiveness or risk-benefit ratios and rarely take bacterial resistance into account. it is well documented that resistant strains of coagulase-negative staphylococci within the resident skin flora increase in both prevalence and population density as duration of therapy increases. acne patients represent a considerable reservoir of resistant strains of these important nos ... | 1998 | 9557228 |
| propionibacterium acnes colonization in acne and nonacne. | propionibacterium acnes is a number of the resident bacterial flora and resides in sebaceous follicles. age-related and body-dependent quantitative differences exist, indicating the role of sebum as an important ecological factor for p. acnes. acne patients demonstrate marked increases in this organism which generates inflammation through a variety of mechanisms. | 1998 | 9557227 |
| enhancement of metastatic potential in a murine fibrosarcoma line by exposure to corynebacterium parvum-elicited macrophages; effect of eicosanoid biosynthesis inhibition. | 1997 | 9547624 | |
| investigation of the mechanism of action of 2% fusidic acid lotion in the treatment of acne vulgaris. | we describe the results of a single-centre, double-blind, vehicle-controlled, parallel group study on the quantitative effects of 2% fusidic acid lotion (fucidin lotion) in facial acne vulgaris. the trial was completed by 52 patients aged 15-25 years with mild to moderate acne who had been randomized to either fucidin lotion (n = 25) or its base (n = 27). primary outcome measures included colony counts of propionibacterium acnes and micrococcaceae and measurements of skin surface lipid free fatt ... | 1997 | 9536540 |
| defective nk cell activity and th1 response in il-18-deficient mice. | il-18 is a cytokine that is secreted from activated macrophages and induces ifngamma production. to investigate the in vivo role of il-18, we generated il-18-deficient mice. in propionibacterium acnes (p. acnes)-primed il-18-deficient mice, lps-induced ifngamma production was markedly reduced, despite normal il-12 induction. natural killer cell activity was significantly impaired. th1 cell response after injection of p. acnes or mycobacterium bovis (bacillus calmette-guerin [bcg]) was significan ... | 1998 | 9529155 |
| two cases of discitis due to propionibacterium acnes. | we report two cases of discitis due to propionibacterium acnes and review previously published cases of bone and joint infections in which this organism was recovered as a pure culture. p. acnes is an anaerobic organism usually considered a normal inhabitant of the skin but capable of producing a variety of infections including discitis, osteitis, arthritis, and chest wall osteitis. most patients were immunocompetent. a few infections occurred spontaneously, whereas others were secondary to a br ... | 1998 | 9523390 |
| all-trans retinoic acid suppresses liver injury induced by propionibacterium acnes and lipopolysaccharide in rats. | all-trans retinoic acid (atra) has been reported to exert major effects on the immune system, including monocytes/macrophages. the present study was designed to determine whether atra would modulate macrophage-associated liver injury induced by propionibacterium acnes and lipopolysaccharide (lps) in rats. all-trans retinoic acid administration alleviated the liver injury and reduced the incidence of death following hepatic failure. serum alanine aminotransferase (alt) levels 5 h after, and survi ... | 1997 | 9504902 |
| entry of monocytes into the brain after injection of corynebacterium parvum. | the receptiveness of the brain to monocyte infiltration was studied in rats that had been injected intracerebrally with corynebacterium parvum. at 0-17 days after intracerebral injection and 18 h after intravenous injection of dii-labeled isogenous mononuclear cells, host rats were sacrificed and cells from the vicinity of the injection site and from the contralateral cerebral hemisphere were dissociated and analyzed by flow cytometry. in rats sacrificed 4-11 days postinjection of c. parvum, dii ... | 1998 | 9500970 |
| a painful spot on the nose. | 1998 | 9492777 | |
| glomerulopathy due to chronic infection of propionibacterium acnes in a patient with felty's syndrome. | 1998 | 9481736 | |
| [acute endocarditis of the native aortic valve caused by propionibacterium acnes]. | propionibacterium acnes is often considered to be a contaminant but it has also been found to be the principal pathogen in serious infections. p. acnes is a rare cause of infective endocarditis. it has been suggested that aortic root abscesses are caused by bacteria that are particularly virulent. the strongest risk factor for serious infections by this bacteria is the presence of foreign bodies. a case is presented in which endocarditis of a native aortic valve caused by p. acnes was associated ... | 1997 | 9470457 |
| prevalence and identity of translocating bacteria in healthy dogs. | bacterial translocation is characterized by the passage of intestinally derived bacteria across the intestinal mucosa to local or regional tissues. this phenomenon is believed to be important in the pathogenesis of gram-negative bacteremia and septicemia; however, the pathway or route of translocation remains unclear. to define the route of translocation better, mesenteric lymph nodes from 50 apparently healthy dogs undergoing elective ovariohysterectomies were cultured aerobically and anaerobic ... | 1997 | 9470154 |
| evaluation of root canal bacteria and their antimicrobial susceptibility in teeth with necrotic pulp. | this study aimed to evaluate the microbiota of necrotic pulp in teeth without carious lesions where the crown and root were intact and to test the sensitivity of this microbiota to antibiotics in order to improve treatment. the necrotic pulp was sampled from 26 single-rooted teeth in intact pulp chambers. a total of 84 strains were isolated. the number of species isolated per tooth varied from 2 to 8, with a strong component (81%) of anaerobic bacteria. the most commonly represented species were ... | 1997 | 9467386 |
| fibronectin binding by propionibacterium acnes. | strains of propionibacterium acnes, isolated from different kinds of orthopaedic and biomaterial-associated infections and from skin flora were shown to express binding of soluble as well as immobilized fibronectin. among these 7 strains isolated from orthopaedic infections, 2 from breast prostheses, and 9 skin isolates, 2, 2, and 5 strains respectively bound immobilized fibronectin. the fibronectin binding was sensitive to protease and heat treatment, and was inhibited by a cell surface extract ... | 1997 | 9453395 |
| [diagnosis and treatment of neurosurgical shunt infections]. | 1997 | 9441323 | |
| an outbreak of foal yersiniosis in poland: pathological and bacteriological examination. | in the springtime of 1995, 10 per cent of foals at a stud-farm died due to suppurative lesions. three dead foals were examined. the manifestations of watery diarrhoea and pneumonia were observed. a profuse growth of an enterotoxigenic strain of yersinia pseudotuberculosis was obtained from the internal organs of the foals. the foals with clinical symptoms of pneumonia and watery diarrhoea were immunized with propionibacterium acnes t. ii. all mares and their offspring from the stud were treated ... | 1997 | 9440204 |
| current options for the topical treatment of acne vulgaris. | the etiopathogenesis of acne vulgaris, a common disorder of youth and adolescence, includes four primary processes: hyperkeratinization (plugging) of the pilosebacous follicles, increased testosterone levels, bacterial colonization with propionibacterium acnes, and inflammation. no single agent has yet been developed that addresses all of these factors. combination regimens, therefore, which usually include an antibiotic and an agent to reduce follicular plugging, have become the mainstay of tre ... | 1997 | 9436851 |
| severe infections caused by propionibacterium acnes: an underestimated pathogen in late postoperative infections. | propionibacterium acnes belongs to the cutaneous flora of humans and is rarely considered a pathogen in human diseases. it is a frequent contaminant in blood cultures; however, in some patients it has been identified as the causative agent of life-threatening infections. within the last years we have observed an abrupt increase in severe p. acnes infections which prompted us to study in detail the clinical and microbiological features, risk factors, and outcomes of these cases. in a retrospectiv ... | 1996 | 9436290 |
| porphyrin sensitization and intracellular calcium changes in the prokaryote propionibacterium acnes. | photosensitization induces intracellular free calcium changes ([ca2+]i) in some eukaryotic cell systems which either contribute to or protect against cell inactivation. we have investigated whether or not similar changes can be induced in prokaryotes. the skin bacterium propionibacterium acnes was sensitized using protoporphyrin ix (pp ix) or 5-aminolevulinic acid (ala). exogenous ala resulted in either a preferential accumulation of protoporphyrin (ala-pp) or of coproporphyrin and/or uroporphyr ... | 1997 | 9432522 |
| colonic perforation by ventriculoperitoneal shunt tubing: a case of suspected silicone allergy. | a case of colonic perforation by a ventriculoperitoneal shunt is presented in a patient with several previous complications associated with shunt tubing. | 1998 | 9428890 |
| susceptibility of propionibacterium acnes, staphylococcus aureus and staphylococcus epidermidis to 10 kampo formulations. | we examined the in vitro sensitivities of three bacteria: propionibacterium acnes, and staphylococcus epidermidis, commonly detected in acne lesions, and staphylococcus aureus, a common cause of skin infections, to 10 kampo formulations (chinese herbal medicines; combinations of powdered extracts of crude drugs). both staphylococcus species showed similar sensitivities to all 10 formulations, with minimum inhibitory concentrations (mics) ranging from 25 to 400 mg/ml. p. acnes, however, was parti ... | 1997 | 9427165 |
| [staphylococcal sepsis associated with platelet transfusion: report of a new case and review of the literature]. | bacterial contamination of blood components is an infrequent although potentially fatal event. bacterial contamination rate of platelet concentrates (pc) varies between 1/900 to 1/2,000 random donor units. however the risk of symptomatic bacteriemias is lower (between 1/2,000 to 1/12,000 random donor units). the organisms most commonly implicated in contaminated pc are gram-positive bacteria such as coagulase negative staphylococci, bacillus cereus or propionibacterium acnes, although gram-negat ... | 1997 | 9424743 |
| [meropenem: microbiologic perspective]. | meropenem is a beta-lactamic carbapenem derived from thienamycin and is structurally characterized by the presence of a beta-methyl group in position c1 which confers stability to the molecule versus renal dehydropeptidase 1 (dhp-1), thereby making the coadministration of an enzyme inhibitor unnecessary. its esterochemical configuration of the lateral chain in c2 (dimethyl carbomoilpyrrolidenethium) increases the activity versus gram negative bacteria (enterobacteria and pseudomonas) and moreove ... | 1997 | 9410064 |
| the relationship between moyamoya disease and bacterial infection. | to examine the relationship between moyamoya disease and bacterial infections, authors studied the serum of 85 cases of moyamoya disease and the influence of propionibacterium acnes (p. acnes) infection on intracranial arteries in rats. the serum levels of p. acnes antibody, igm, transferrin (tf), alpha 2-macroglobulin (alpha 2m) were significantly higher in moyamoya disease than in normal volunteers. moyamoya-like changes of the intracranial internal carotid arteries were histopathologically de ... | 1997 | 9409442 |
| multicenter evaluation of the updated and extended api (rapid) coryne database 2.0. | in a multicenter study, 407 strains of coryneform bacteria were tested with the updated and extended api (rapid) coryne system with database 2.0 (biomérieux, la-balme-les-grottes, france) in order to evaluate the system's capability of identifying these bacteria. the design of the system was exactly the same as for the previous api (rapid) coryne strip with database 1.0, i.e., the 20 biochemical reactions covered were identical, but database 2.0 included both more taxa and additional differentia ... | 1997 | 9399506 |
| il-18 accounts for both tnf-alpha- and fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice. | when lps is administered to heat-killed propionibacterium acnes-primed balb/c nude mice, they develop endotoxin-induced liver injury. as previously reported, this liver injury can be prevented by treatment with an ab against il-18, a novel cytokine with the ability to induce ifn-gamma production and up-regulate functional fas ligand (fasl) expression. to identify the pathologic role of il-18 in this liver injury, we investigated the hepatic cytokine network and fasl induction after lps challenge ... | 1997 | 9378984 |
| ph-dependent changes of nitric oxide, peroxynitrite, and reactive oxygen species in hepatocellular damage. | low arterial blood ph and sustained nitric oxide (no) production are critical parameters in inflammatory events such as sepsis, and appropriate treatment is still under debate. because the stability of nitrogen and oxygen intermediates is dependent on the surrounding ph, we investigated whether the relationship among no, peroxynitrite (onoo-), and reactive oxygen species production also depends on the ph value, particularly with respect to their effects on hepatocellular damage. our studies demo ... | 1997 | 9374710 |
| pleural malignancies. | carcinoma of the lung, metastatic breast carcinoma, and lymphoma are responsible for approximately 75% of all malignant pleural effusions. the presence of malignant cells in the pleural fluid or in the parietal pleura confirms the diagnosis. recently, several authors have proposed the combination of morphometric procedures and quantitative analysis of nucleolar organizer regions stained by silver nitrate. videothoracoscopy is recommended for patients suspected of having a malignant pleural effus ... | 1996 | 9363162 |
| delayed infection after elective spinal instrumentation and fusion. a retrospective analysis of eight cases. | a retrospective analysis of eight cases of delayed spinal infection after elective posterior or combined anterior and posterior spinal instrumentation and fusion. | 1997 | 9355228 |
| effects of exercise on the macrophage mhc ii response to inflammation. | the purpose of this investigation was to determine the effects of different doses of exercise on the ability of propionibacterium acnes (p. acnes) to induce major histocompatibility complex (mhc) ii antigen expression on macrophages (m phi's). pathogen-free male balb/c mice were exercised on a treadmill moderately (mod, 15-17 m/min, 5% grade, 30 min/day) or exhaustively (exh, 15-40m/min, 5% grade, 2-4hr/day) for a period of 7 days during p. acnes-induced inflammation. a control group (con) consi ... | 1997 | 9351697 |
| comparison of serum antibiotic levels in acne patients receiving the standard or a modified release formulation of minocycline hydrochloride. | serum levels of minocycline hydrochloride were determined by bioassay in a total of 223 acne patients (123 male, 100 female) receiving either the recommended dose (100mg/day) or a high dose (200mg/day) of the standard preparation (101 patients) of a modified release formulation (132 patients). sera were collected within 6 h of the morning dose 7-10 days after the start of treatment. mean minocycline serum levels were consistently higher in females than in males, irrespective of dose or formulati ... | 1997 | 9330069 |
| spread of antibiotic-resistant bacteria from acne patients to personal contacts--a problem beyond the skin? | 1997 | 9329508 | |
| does oral isotretinoin prevent propionibacterium acnes resistance? | oral and topical antibiotics play a major role in acne therapy. physicians base treatment choices on personal perceptions of efficacy, cost-effectiveness or risk-benefit ratios and rarely take bacterial resistance into account. propionibacterium acnes isolates resistant to one or more anti-acne antibiotics have been reported in europe, the usa, japan and new zealand. therapeutic failure on some but not all antibiotic regimens is an increasing management problem. in leeds, uk, resistant strains a ... | 1997 | 9310739 |
| bacterial flora of stethoscopes' earpieces and otitis externa. | external otitis caused by staphylococcus aureus was observed in a nurse after extensive use of a stethoscope. the infection recurred and a similar organism was isolated from the stethoscope's earpiece. the infection did not recur after the earpiece was cleansed after each use. in a prospective study, the bacterial flora of 35 earpieces was evaluated. fifty-three isolates, 36 aerobic or facultative and 17 anaerobic, were recovered. the number of organisms per earpiece ranged from 14 to 204 (avera ... | 1997 | 9302906 |
| effects of non-specific immunopotentiators in experimental schistosoma mansoni infection. ii. corynebacterium parvum. | the effects of corynebacterium parvum on host protection, tissue reaction and "in vivo" chemotaxis in schistosoma mansoni infected mice were studied. the c. parvum was given intraperitoneally using a dose of 0.7 mg, twice a week (for 4 weeks), thirty days before (prophylactic treatment) or after infection (curative treatment). the host protection was evaluated through the recovery of adult worms by liver perfusion and was lower in the prophylactic group as compared to the control group (p = 0.01 ... | 1996 | 9293078 |
| immunotherapy and cytokines. | immunomodulation is now possible in veterinary medicine with the licensure of a number of biological products by the united states department of agriculture for veterinary use. these products activate primarily macrophages, induce the production of cytokines, and have various effects on the activity and proliferation of b and t lymphocytes. those products most commonly used are inactivated whole bacteria of propionibacterium acnes, cell wall fractions of nonpathogenic mycobacterium spp, and the ... | 1997 | 9283244 |
| inhibition of nitric oxide synthesis improves detoxication in inflammatory liver dysfunction in vivo. | inflammatory stimulation of the liver induces nitric oxide (no) biosynthesis and suppression of detoxication. in this study the effect of no biosynthesis on cytochrome p-450 (cyp) enzyme activity was investigated by comparing in vivo and in vitro assays. to establish liver inflammation, cd rats were injected with corynebacterium parvum (c. parvum) suspension. after 5 days no biosynthesis was highly induced as indicated by increased no2- plus no3- serum concentrations. at the same time the aminop ... | 1997 | 9277434 |
| postoperative endophthalmitis: incidence, predisposing surgery, clinical course and outcome. | to describe the predisposing surgery, clinical course and final visual outcome for patients with culture-proven and culture-negative postoperative endophthalmitis. | 1997 | 9276117 |
| culture and biological activity of propionibacterium acnes. | administration of killed propionibacterium acnes to experimental animals leads to the development of hypersensitivity to the lethal and cytokine-inducing effects of endotoxin. this sensitizing property of p. acnes is not always expressed by different bacterial preparations. its expression depends very much on the conditions employed for the cultivation of this microorganism. the present study investigates which culturing conditions result in p. acnes preparations with optimal sensitizing propert ... | 1997 | 9266265 |
| propionibacterium endophthalmitis following molteno tube repositioning. | we describe an aphakic patient who developed recurrent propionibacterium acnes endophthalmitis after molteno tube revision. | 1997 | 9264297 |
| advances and perspectives in acne therapy. | acne is one of the most common diseases in dermatology. it is of considerable esthetic significance, which explains the mental stress in affected patients. although acne almost always heals spontaneously in early adulthood, treatment measures can shorten the course, reduce the severity of the disease, and avoid complications such as scarring. treatment has changed substantially in recent years. in accordance with pathogenic principles, effective treatment is possible. in most patients, a combina ... | 1997 | 9262484 |
| characterization of tumor necrosis factor-deficient mice. | although tumor necrosis factor (tnf) initially came to prominence because of its anti-tumor activity, most attention is now focused on its proinflammatory actions. tnf appears to play a critical role in both early and late events involved in inflammation, from localizing the noxious agent and amplifying the cellular and mediator responses at the local site and systemically, to editing (e.g., apoptosis) injured cells or effete immune cells and repairing inflammatory damage. we have generated mice ... | 1997 | 9223320 |
| identification and antibiotic sensitivity of bacteria isolated from periapical lesions. | periradicular tissues from 28 refractory endodontic cases requiring surgical intervention were submitted for histological diagnosis and microbiological culture. bacteria isolated from these lesions were identified and then tested for their antibiotic sensitivity to a panel of common antibiotics. the periapical tissue specimens of 22 out of 28 lesions (79%) contained microorganisms. of the 22 cases showing positive growth cultures, 15 were polymicrobial and 7 were single species isolates. fifty-t ... | 1997 | 9220741 |
| igg subclasses specific to staphylococcus epidermidis and propionibacterium acnes in patients with acne vulgaris. | igg subclasses specific to staphylococcus epidermidis and propionibacterium acnes were determined in sera from patients with mild, moderate or severe acne and from a control group. titres specific to s. epidermidis were all within the same range and did not differ between groups. the titres of igg subclasses to specific to p. acnes did vary between groups. igg1 and igg3 were significantly higher in severe acne patients compared with moderate acne patients, while igg2 was significantly higher in ... | 1997 | 9205507 |
| propionibacterium acnes treatment diminishes cd4+ nk1.1+ t cells but induces type i t cells in the liver by induction of il-12 and il-18 production from kupffer cells. | lps injection into normal mice does not induce liver injury, while the same treatment of propionibacterium acnes-primed mice induces severe liver injury, indicating that p. acnes treatment renders the mice susceptible to lps. since ifn-gamma sensitizes macrophages to lps, we investigated the mechanism of induction and activation of ifn-gamma-producing (type 1) t cells by p. acnes. twenty percent of liver lymphocytes of c57bl/6 mice are cd4+ nk1.1+ t cells that promptly produce il-4 in response t ... | 1997 | 9200444 |
| failure of intravenous antibiotic therapy of multiple temporal brain abscesses due to propionibacterium acnes requiring temporal lobectomy. | propionibacterium acnes is a common skin colonizer. its involvement in brain abscesses is generally described as a complication of neurosurgical intervention. propionibacterium acnes is susceptible to antibiotics used as treatment of anaerobic infections, except for the 5-nitroimidazoles. surgical excision or drainage of a simple abscess combined with a long course of antibiotics is considered the treatment of choice. a case of a patient with multiple brain abscesses located in the right tempora ... | 1997 | 9200038 |
| pyogenic vertebral osteomyelitis. | i retrospectively reviewed the records of 111 patients who had pyogenic vertebral osteomyelitis unrelated to an open procedure on the spine. the mean age at the time of the diagnosis was sixty years (range, eighteen to eighty-four years); sixty-one patients (55 per cent) were sixty years old or more. forty-four patients (40 per cent) had an impaired immune system secondary to diabetes mellitus, the use of corticosteroids, chemotherapy for cancer, rheumatic or immunological disease, renal or hepa ... | 1997 | 9199385 |
| current management of acne. | 1997 | 9183086 | |
| ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo. | 1. ro 32-3555 (3(r)-(cyclopentylmethyl)-2(r)-[(3,4,4-trimethyl-2,5-dioxo-1- imidazolidinyl)methyl]-4-oxo-4-piperidinobutyrohydroxamic acid) is a potent, competitive inhibitor of human collagenases 1, 2 and 3 (ki values of 3.0, 4.4 and 3.4 nm, respectively). the compound is a selective inhibitor of collagenases over the related human matrix metalloproteinases stromelysin 1, and gelatinases a and b (ki values of 527, 154 and 59 nm, respectively). 2. ro 32-3555 inhibited interleukin-1 alpha (il-1 a ... | 1997 | 9179398 |
| experimental hepatitis in neonatally thymectomized mice: transfer of disease and the role of t cells. | using neonatally a/j thymectomized mice, we have produced chronic hepatitis by administration of sublethal doses of propionibacterium acnes and lipopolysaccharide (lps). our goal in this unique model was to evaluate the effector cell population required to generate chronic hepatitis by transferring spleen cells or splenic subpopulations derived from donor thymectomized mice with chronic hepatitis into congenic recipient nonimmunized thymectomized or sham-thymectomized animals. several key observ ... | 1997 | 9175920 |
| [pharma clinics. drug of the month. benzamycin, an up-date on topical treatment of acne]. | 1997 | 9173479 | |
| propionibacterium acnes, a resident of lipid-rich human skin, produces a 33 kda extracellular lipase encoded by geha. | five independent clones of the propionibacterium acnes p-37 lipase gene (geha) were obtained in escherichia coli, and the gene was localized to a 2.75 kb xhol fragment by subcloning. the five clones were shown to contain the same gene by southern blotting with a dig-labelled probe to geha. the nucleotide sequence of geha was determined, and shown to contain a single orf of 1017 kb, encoding a protein of 339 amino acids. the predicted molecular mass was 36 kda. a 33 kda (page) radiolabelled polyp ... | 1997 | 9168624 |
| adjuvant therapy for melanoma. | the search for effective adjuvant therapy for melanoma has resulted in the testing of a remarkably broad spectrum of therapeutic agents. until recently, there was little evidence to suggest a benefit for any adjuvant therapy. the demonstration of activity for adjuvant high-dose interferon alfa in a cooperative group trial resulted in food and drug administration approval and has dramatically changed the melanoma landscape. this article reviews all the randomized adjuvant trials conducted to date ... | 1997 | 9161800 |
| bacteraemia caused by periodontal probing. | bacteraemia of oral origin may result in infective endocarditis in susceptible individuals. the aim of this pilot study was to investigate the occurrence of bacteraemia due to periodontal probing. thirty patients (15 male, 15 female; mean age 42.7 years) with untreated periodontitis were investigated. all were free of significant medical disorders and none had taken antibiotics in the previous month. prior to and immediately following periodontal probing, 20 ml of venous blood were obtained from ... | 1997 | 9153833 |
| exocellular phospholipase c activity from a propionibacterium acnes strain isolated from a periodontal pocket. | the culture supernatant of a strain of propionibacterium acnes was investigated for its phospholipase (pl) activity. the microorganism was isolated from a periodontal pocket of a patient with periodontal disease. supernatants from cultures of this microorganism were used as a source to obtain enzymes. proteins from the supernatants were concentrated, and their enzymatic activity was partially purified through molecular sieving. the procedure yielded two peaks of activity. this activity was shown ... | 1997 | 9150042 |
| [propionibacterium acnes infection in patients with csf shunts]. | propionibacterium acnes is a common inhabitant of human skin rarely associated with clinical disease. however it has been recognized as a cause of shunt and postneurosurgical infections. from january 1992 to june 1995, 5,947 cerebrospinal fluid (csf) samples were cultured in our laboratory. we carried out a clinical-epidemiological study in patients where p. acnes was isolated from csf. | 1997 | 9147504 |
| chronic propionibacterium acnes endophthalmitis as a cause of intermediate uveitis. | although the pathogenesis in most cases of intermediate uveitis is unknown, a small minority of cases is associated with a variety of specific inflammatory etiologies: sarcoidosis; multiple sclerosis; lyme disease; syphilis; ocular lymphoma; and as a rare manifestation of behçet's disease and aids. a 61-year-old woman developed pars planitis after cataract surgery. a vitrectomy was performed after ten months when a white capsular plaque and an hypopyon developed. propionibacterium acnes was isol ... | 1997 | 9145695 |
| preventive effect of cyclosporin a on experimentally induced acute liver injury in rats. | we examined the effect of cyclosporin a (csa) on the pathogenesis of acute experimental liver injury in rats induced by injection of heat-killed propionibacterium acnes (p. acnes) and subsequent injection of lipopolysaccharide (lps). pretreatment with csa significantly reduced serum alanine aminotransferase (alt), serum tumor necrosis factor-alpha (tnf-alpha) production, without changing the tnf-alpha mrna level in the liver, and plasma interferon-gamma (ifn-gamma), following lps injection in th ... | 1997 | 9138282 |
| tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis. | accumulating evidence implicates tumor necrosis factor (tnf) and fas systems in liver injury, although the interaction between these two systems remains to be investigated. in this study, we examined propionibacterium acnes-primed tnf receptor p55-deficient (tnfrp55-/-) or fas-deficient mrl/mpj lpr/lpr mice challenged with lipopolysaccharide (lps). priming with p. acnes caused mononuclear cell infiltration into the hepatic lobules and granuloma formation in the livers of tnfrp55 wild-type mice. ... | 1997 | 9125577 |
| a retrospective analysis of microbial contaminants in outdated random-donor platelets from multiple sites. | platelet components contaminated with bacteria are an important source of transfusion-associated bacterial sepsis. estimates of contamination rates vary widely (0-10%) and are highly controversial. the present study, designed with stringent testing regimens, retrospectively determined the prevalence of microbial contaminants in platelets from four collection regions. | 1997 | 9122897 |
| bacterial lipopolysaccharide rapidly inhibits expression of c-c chemokine receptors in human monocytes. | the present study was designed to investigate the effect of bacterial lipopolysaccharide (lps) on c-c chemokine receptors (ccr) expressed in human mononuclear phagocytes. lps caused a rapid and drastic reduction of ccr2 mrna levels, which binds mcp-1 and -3. ccr1 and ccr5 mrnas were also reduced, though to a lesser extent, whereas cxcr2 was unaffected. the rate of nuclear transcription of ccr2 was not affected by lps, whereas the mrna half life was reduced from 1.5 h to 45 min. as expected, lps- ... | 1997 | 9120403 |
| cloning and sequencing of the hyaluronate lyase gene from propionibacterium acnes. | the hyaluronate lyase (hyaluronidase) gene from propionibacterium acnes was cloned and sequenced. the gene was isolated on an ecori-generated 3-kb piece of dna. expression was less in escherichia coli than in p. acnes; in e. coli, active enzyme was only cell associated and not secreted. the gene is 2256-pb long and codes for a protein of 82 kda. amino terminal sequencing of the protein of the partially purified gene indicated the presence of a 32-amino-acid leader sequence. the leader sequence s ... | 1997 | 9115089 |
| therapy for acne vulgaris. | 1997 | 9099661 | |
| essential roles of the fas ligand in the development of hepatitis. | the fas ligand (fasl) is expressed in activated t cells and induces apoptosis in fas-bearing cells. a cytotoxic t lymphocyte (ctl) clone specific for hepatitis b surface antigen (hbsag) causes an acute liver disease in hbsag transgenic mice. here we observed that the ctl clone killed hepatocytes expressing hbsag in a fas-dependent manner. administration of the soluble form of fas into hbsag transgenic mice prevented the ctl-induced liver disease. in the second model, mice were primed with propio ... | 1997 | 9095174 |
| [propionibacterium acnes empyema]. | 1997 | 9091110 | |
| immunohistochemical and ultrastructural analyses of in situ activation of hepatic stellate cells around propionibacterium acnes-induced granulomas in the rat liver. | stellate cells embrace the hepatic sinusoids as pericytes. to demonstrate their activation in juxta-sinusoidal location, we induced hepatic granulomatous inflammation, which did not accompany liver injury nor fibrosis, by administrating a low dose (10 mg/kg b.w.) of heat-killed propionibacterium acnes into rats. macrophages and lymphocytes migrated out of the sinusoid and made compact granulomas in the space of disse. stellate cells which faced on the granulomas were closely attached to the sinu ... | 1997 | 9066151 |