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exhaustive hybridization and its application to an analysis of the ribonucleic acid synthesized in t4-infected cells. 19684868543
some steps in the assembly of bacteriophage t4. 19684868422
assembly of the tail of bacteriophage t4. 19684868421
location of glucosyl transferase genes on the genetic map of phage t4. 19684867911
acridine binding by escherichia coli: ph dependency and strain differences.acridine dye binding by cells of escherichia coli has been characterized in terms of a number of parameters. there is a temperature-dependent, readily reversible binding of acriflavine which occurs to a greater extent with acridine-sensitive mutants of e. coli k-12 than with wild-type e. coli b or k-12. there is an essentially irreversible internal binding of acriflavine which occurs when the cellular permeability barriers are destroyed or altered by heat-treatment, elevated ph, treatment with t ...19684867737
early intracellular events in the replication of t4 phage dna, iv. host-mediated single-stranded breaks and repair in ultraviolet-damaged t4 dna. 19674866987
enzymatic synthesis of deoxyribonucleic acid. xxv. purification and properties of deoxyribonucleic acid polymerase induced by infection with phage t4. 19684866523
on the requirement for formyl residues in the synthesis of bacteriophage t4 proteins. 19674866444
transcription during bacteriophage t4 development: synthesis and relative stability of early and late rna. 19684866329
polyriboadenylate polymerase and its inhibition in t4-infected escherichia coli and shigella dysenteriae. 19684866301
non-repeating nucleotide sequences in the genome of bacteriophage t4. 19684866115
purification of bacteriophage t4 lysozyme. 19684865643
transformation in phage t4: minmal recognition length between donor and recipient dna. 19674865571
a frame-shift mutation resulting in the deletion of two base pairs in the lysozyme gene of bacteriophage t4. 19674865145
methylation of rna in bacteriophage t4 infected escherichia coli. 19674864798
the action of 5-azacytidine on bacteria infected with bacteriophage t4. 19674863910
effect of acridine orange on survival and capacity of escherichia coli b for t3 and t4 phage during anoxia. 19674863401
[study of the genetic code with t4 phage lysozyme]. 19674863362
the mechanism of lysis in phage t4-infected cells. 19674863172
incorporation of uracil-14c into nucleic acids in escherichia coli infected with bacteriophage t4 and t4 amber mutants. 19674863170
characterization of revertants of e. coli wu36-10 and wp2 using amber mutants and an ochre mutant of bacteriphage t4. 19674862436
interference of bacteriophage t4 in the reproduction of rna-phage m12. 19674861612
detection of a peptide determined by the rii b cistron of phage t4. 19674861309
presence of t4 "early" messenger rna on polysomes late in infection. 19674861178
studies on the mechanism of bacteriophage t4 interference with host metabolism. 19674860987
mutants of bacteriophage t4 unable to induce dihydrofolate reductase activity. 19674860754
low-molecular-weight t4 phage-specific rna. 19674860429
the interaction of acetylcholinesterase with specific inhibitors conjugated to bacteriophage t4 and of proteins. 19744857340
[effect of prednisolone on the serum tsh, t3 and t4 in a case of hypothyroidism caused by chronic thyroiditis with inflammatory symptoms]. 19744857018
the use of the t4 dna polymerase in identification of 3' terminal nucleotide sequences of duplex dna. 19744855152
recovery of phage t4 from nitrous acid damage. 19744854053
two modes of in vivo transcription for genes 43 and 45 of phage t4.sensitivities of the expression of early genes of phage t4 to uv light were determined at various stages of intracellular development of t4 wild type, a dna-negative mutant (t4 do), and t4 tsg1, (a mutant that exhibits delayed expression of some t4 early genes). whereas the sensitivities of some genes in the t4 wild type and t4 do remain constant, genes 43 and 45 exhibit greatly reduced sensitivities several minutes after the onset of phage development. since uv sensitivities are a measure of th ...19744847327
point mutants in the d2a region of bacteriophage t4 fail to induce t4 endonuclease iv.we have studied the properties of presumptive point mutants in the d2a region of bacteriophage t4. dominance tests showed that the d2a mutation was recessive to the wild-type allele. the mutations were shown to map in the d2a region by complementation against rii deletions. the d2a mutations were also located between gene 52 and riib by two- and three-factor crosses. the mutants are located at at least two distinct loci in the d2a region. the point mutants grow normally on all hosts tested and n ...19744847325
characterization of bacteriophage t4 dna on the basis of an asymmetric distribution of (g plus c)-rich and (a plus t)-rich segments and their bearing on early and late mrna transcription. 19744841174
free triiodothyronine (t3)- and thyroxine (t4) serum levels in old age. 19744834667
structural aberrations in t-even bacteriophage. v. effects of canavanine on the maturation and utilization of specific gene products.previous results have shown that when a t-even bacteriophage-infected cell was exposed to l-canavanine followed by an exposure to l-arginine, a monster phage particle, termed a lollipop, was formed. l-canavanine was necessary for the induction event but l-arginine was required for the maturation of the particle. we now describe the effects of canavanine on the maturation of certain t4 proteins and their role in the induction of lollipops. the cleavage reactions of the head proteins p22, p23, p24 ...19744833614
structural aberrations in t-even bacteriophage. iv. parameters of induction and formation of lollipops.previous results from our laboratory have shown that when a t-even bacteriophage-infected bacterial cell was exposed to l-canavanine followed by an l-arginine chase, a monster phage particle, termed a lollipop, was formed. we now describe certain parameters concerning (i) the induction and (ii) the formation of t4 lollipops. the induction step involves a t4 late function, and can require only a 3-min exposure to l-canavanine. short pulses of l-canavanine result in the formation of shorter lollip ...19744833613
is bacteriophage t4 dna polymerase involved in the repair of ultraviolet damage? 19744833546
studies on phage internal proteins. 3. specific binding of t4 internal proteins to t4 dna. 19744833538
evidence for the absence of terminal redundancy in the genome of t4 "light" particles. 19744826207
protein composition of the tail and contracted sheath of bacteriophage t4. 19744826201
the genetic mechanism of the integration of fragments of transforming dna of phage t4 and its relationship to the problem of high negative interference. 19744824838
size and folding of the messenger for phage t4 lysozyme. 19744819638
rapid radioimmunoassay for both t4 and t3 in the same sample of human serum. 19744815178
thyroxine (t4) and triiodothyronine (t3): effects of iodine on the serum concentrations and disposal rates in subjects from an endemic goiter area. 19744815170
dependence of the uv sensitivity of phage t4 on the localization of conditionally lethal (amber) mutations in the genome. 19734804064
[thyroxine (t4) determination by radioimmunological method in dried blood eluate: new diagnostic method of neonatal hypothyroidism?]. 19734799831
packing of dna molecules inside bacteriophages t7, n4 and t4. 19734792948
[t4 determination using "oxford t4 column" test and murphy-pattee method. amethodical comparison]. 19734790144
[control of substitution therapy in hypothyroid children using the t3 and t4 test]. 19734786246
a simple method for atp determination in bacteriophage t4. 19734784861
transient electric birefringence of t-even bacteriophages. i. t4b in the absence of tryptophan and fiberless t4 particles. 19734780722
[t3 and t4 kinetics in the elderly. production rates (author's transl)]. 19734779733
presumptive d2a point mutants of bacteriophage t4.mutants of bacteriophage t4 have been isolated that show phenotypes seen previously with those rii deletions that extend into the nearby d2a region. analysis indicates that rii mutations are not necessary in order to get the d2a phenotypes.19734776969
[t4-test, thyro-binding-index, and free-thyroxine-index in children (author's transl)]. 19734769931
characterization of nuclear polyhedrosis virus dnas.the nuclear polyhedrosis virus dnas characterized and compared in this study consist of the singly-enveloped nucleocapsids (snpv) of trichoplusia ni and the bundles of nucleocapsids common to a single envelope (mnpv) from spodoptera frugiperda and rachiplusia ou. the snpv and mnpv dnas are very similar in hydrodynamic properties and molecular weights. in addition, the npv dnas are similar in size to those extracted from the granulosis viruses that infect t. ni and s. frugiperda. as isolated from ...19734761726
proceedings: the radioimmunoassay of free (diffusible) t3 and t4 concentrations in serum. 19734759610
assembly of bacteriophage t4 tail fibers. iv. subunit composition of tail fibers and fiber precursors. 19734758066
t4 bacteriophage trnagly. 19734756786
letter: crystallographic data fro lysoxyme from bacteriophage t4. 19734754847
the invariance of mutation rates in bacteriophage t4 as functions of medium ph. 19734753931
purification of t4 phage by adsorption on polylysine agarose. 19734753762
nucleotide sequence of a glycine transfer rna coded by bacteriophage t4. 19734753761
[intrathyroid iodine metabolism and biological half-life of t4 in children]. 19734751476
intragenic complementation between temperature-sensitive mutants of gene 42 (dcmp hydroxymethylase) of bacteriophage t4.interallelic complementation between certain temperature-sensitive mutants of gene 42 of bacteriophage t4 was demonstrated by measuring the incorporation of labeled thymine into dna.19734747990
replicative hybrid of t4 bacteriophage dna.hybrid density replicative t4 dna was isolated from cscl, sheared, and reanalyzed in cscl. the results rule out a branched model for t4 dna replication and confirm that t4 dna replicates to a conventional, semiconservative, colinear hybrid.19734747988
multiple initiation of bacteriophage t4 dna replication: delaying effect of bromodeoxyuridine.effects of bromodeoxyuridine (budr) substitutions in phage t4 dna on the initial stages of dna replication were investigated. electron microscope studies of partially replicated, light (thymidine-containing) t4 dna revealed the presence of multiple loops and forks. these dna preparations had no budr in either parental or newly synthesized dna, and the observations thus show that multiple initiation of dna replication is a normal event in t4 development and is not caused by the presence of budr. ...19734747986
t4 extraction efficiencies of three alcohols. 19734743037
[examination of tsh (thyroid stimulating hormone) test using t4 level in the blood as an index]. 19734736418
detection of antibodies specific for ftc, dns and myoglobin by neutralization of conjugated bacteriophage t4. 19734734807
crystalline t4 bacteriophage. 19734732075
involvement of bacteriophage t4 genes in radiation repair. 19734731014
function of the bacteriophage t4 transfer rna's. 19734729526
late gene function in bacteriophage t4 in the absence of phage dna replication. 19734729525
modification of column chromatography in t4 analysis. 19734728960
the urinary excretion of triiodothyronine (t3) and thyroxine (t4) in man. 19734720945
the genetic control of spontaneous and induced mutation rates in bacteriophage t4. 19734711557
in vitro characterization of a mutator t4 dna polymerase. 19734711554
the unexpected location of a gene conferring abnormal radiation sensitivity on phage t4. 19734700894
relationship between molecular weight of t4 phag-induced deoxynucleotide kinase and the size of its messenger ribonucleic acid. 19734700455
studies on t4-induced nucleases. isolation and characterization of a manganese-activated t4-induced endonuclease. 19734692845
radiation sensitive mutants of phage t4. a comparative study. 19734686984
[new semi-automated method for the determination of serum thyroxine(t4) using the t4 column (oxford company) and autoanalyzer--a new method using chloride as an activator]. 19724674583
a genetic assay for transversion mutations in bacteriophage t4. 19724662742
[comparison of automated chemical determination of plasma hormonal iodine and thyroxinemia measured by competition (t4 test)]. 19724661591
[reciprocal action of dna dependent rna polymerase with t4-dna and desoxyribonucleotides]. 19724649768
chemical synthesis of two deoxyribopolynucleotide fragments containing the natural sequence of t4 lysozyme gene e. 19724640369
[various results of t3 and t4 tests in autonomous thyroid nodules before and after treatment]. 19724639003
bacteriophage t4 head maturation: release of progeny dna from the host cell membrane.we have presented a new approach to studying bacteriophage t4 head maturation. using a modified m-band technique, we have shown that progeny deoxyribonucleic acid (dna) was synthesized on the host cell membrane throughout infection. this dna was released from the membrane later in infection as the result of formation of the phage head; detachment of the dna required the action of gene products 20, 21, 22, 23, 24, 31, 16, 17 and 49, known to be necessary for normal head formation. gene products 2 ...19734632440
serological relatedness of bacterial deoxyribonucleic acid polymerases.a number of bacterial species have been surveyed for serological activities with antiserum to escherichia coli b deoxyribonucleic acid (dna) polymerase i (ec 2.7.7.7.). the degree of serological cross-reaction is taken as a measure of relatedness of both the enzyme molecules from various species and the bacterial species themselves. extracts were assayed by complement fixation only after treatment with deoxyribonuclease, since dna bound to dna polymerase alters the serological activity of the en ...19734630512
use of a clonal line of porcine kidney cell cultures for primary isolation and vaccine studies with adenoviruses.the clonal line (y15) of porcine kidney stable cells provided a recovery system for adenovirus t4 from specimens from adults with respiratory illnesses that was as sensitive as human embryo kidney cultures. adenoviruses t7 from adults, and t1, 2, 3, and 5 from children could be readily isolated in porcine kidney cell cultures. the latter were useful for adenovirus vaccine studies in that infectivity titers of live virus vaccine and neutralization antibody responses after vaccination were equal t ...19724629702
human prolactin and thyrotropin concentrations in the serums of normal and hypopituitary children before and after the administration of synthetic thyrotropin-releasing hormone.synthetic thyrotropin-releasing hormone (trh) was administered to normal children and hypopituitary patients in a dose of 7 mug/kg i.v. over 30-60 sec. serum thyrotropin (tsh) and prolactin (hpr) concentrations were measured by radioimmunoassay before and at 15-min intervals for 2 hr after trh. in 20 normal children hpr rose from a mean baseline value of 7.0+/-1.2 (sem) ng/ml to a mean peak value of 39.5+/-5 ng/ml. in 11 patients with growth hormone (gh) deficiency without tsh deficiency. hpr va ...19724626583
[induction of mutations in the bacteriophage t4 by a treatment of bacteria with 2 amino-purine before the infection]. 19724625040
product of t4 gene 12. 19724624817
metabolism of t4 bacteriophage ghost-infected cells. ii. do ghosts cause a generalized permeability change?ghosts appear to alter the barrier function of the cell membrane, allowing the release of phosphorylated sugars which normally cannot pass through the cell membrane, whereas phage do not. no increased influx of normally impermeable compounds is observed in the presence of ghosts, indicating that the loss of membrane function after ghost infection cannot be attributed to a generalized breakdown of the permeability barrier.19724624785
effect of nalidixic acid on the growth of deoxyribonucleic acid bacteriophages.the effect of nalidixic acid on the growth of various deoxyribonucleic acid (dna) bacteriophages has been investigated by one-step growth experiments. the escherichia coli bacteriophages t5, lambda, t7 and phir are strongly inhibited by nalidixic acid, whereas t4 and t2 are only partially inhibited. the bacillus subtilis bacteriophages sp82, sp50, and phi29 are relatively unaffected by nalidixic acid. there is no correlation between those bacteriophages which can grow in the presence of nalidixi ...19724621668
[the suppressor gene contained in the genome of t4 phage]. 19744620269
[transcription time of phage t4 genes and its relation to chromosome replication]. 19734619992
[genetic transformation of phage t4rii-638 by phage t4 deoxyribonucleic acid. xvi. effect of phage t4 gene v and bacterial genes rec a and uvr a on the effectiveness of phage t4rii-638 transformation]. 19734619991
phospholipase a-deficient mutants of escherichia coli b.phospholipase a-deficient mutants were isolated from escherichia coli b/sm as follows. replica plates were incubated to allow formation of colonies and then overlayed with soft agar containing washed sheep erythrocytes, lecithin ca++, colistin, lysozyme and streptomycin. the mutant colonies were detected as colonies without hemolytic zones. two or three cycles of treatment with mutagen and selection were necessary for their isolation. the mutants obtained could grow in a synthetic medium with g ...19744619011
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