Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| enzymic joining of polynucleotides. 8. structure of hybrids of parental t4 dna molecules. | 1969 | 4904104 | |
| enzymic joining of polynucleotides. vii. role of the t4-induced ligase in the formation of recombinant molecules. | 1969 | 4904103 | |
| the induction of trna synthesis following t4 phage infection. | 1969 | 4902823 | |
| control of gene function in bacteriophage t4. i. ribonucleic acid and deoxyribonucleic acid metabolism in t4rii-infected lambda-lysogenic hosts. | deoxyribonucleic acid (dna) synthesis in t4rii-infected, lambda-lysogenic strains of escherichia coli proceeds with one-half the rate of t4 wild-infected bacteria and stops 16 min after infection at 37 c. the rates of ribonucleic acid (rna) synthesis, however, are the same with t4rii and t4 wild. the turnover of pulse-labeled rna is slow in k strains (half-lives 10 to 20 min) as compared with b strains (half-lives 2.5 to 6 min). lambda-lysogeny increases the apparent messenger (m) rna half-lives ... | 1969 | 4902633 |
| the genome of bacteriophage t4. | 1969 | 4902619 | |
| bacteriophage t4-induced deoxycytidine triphosphate-deoxyuridine triphosphate nucleotidohydrolase: its properties and its role during phage infection of escherichia coli. | 1969 | 4902261 | |
| mutagenic effect of sensitized irradiation of bacteriophage t4. | 1969 | 4902206 | |
| dna-dependent synthesis of rna by escherichia coli rna polymerase: release and reinitiation of rna chains from dna templates. | rna synthesis in an in vitro rna polymerase system at low ionic strength soon ceases, due to inhibition by accumulated rna. measurement of rna chain initiation by the incorporation of gamma-(32)p-atp and gtp with native t2 or t4 dna as template shows that only one rna chain is formed per molecule of enzyme added. in contrast, when the polymerase reaction is carried out in 10 mm mg(++) and 0.2 m kcl, rna synthesis proceeds nearly linearly for hours, resulting in a marked increase in accumulated r ... | 1969 | 4901708 |
| ribonuclease v of escherichia coli. i. dependence on ribosomes and translocation. | a new rnase activity, tentatively named rnase v, was found in cell-free extracts of e. coli. this activity requires ribosomes, g and t factors, trna, k(+) or nh(4) (+), mg(2+), gtp, and a sulfhydryl compound to degrade poly u, poly a, t4 phage mrna, or e. coli mrna. rnase v is specific for mrna; it does not attack ribosomal rna. it is inhibited by antibiotics that decrease breakdown of mrna in vivo, such as chloramphenicol and streptomycin, and by such agents as 5'-beta, gamma-methylene-guanosin ... | 1969 | 4901707 |
| bacteriophage t4 dna-dependent in vitro synthesis of lysozyme. | a cell-free system derived from uninfected escherichia coli previously was shown to synthesize beta-glucosyl transferase in response to t4 dna. this same in vitro system, when incubated at slightly higher magnesium concentrations, also synthesized enzymatically active lysozyme. the lysozyme activity that appeared was judged to be t4-specific since antibodies prepared against authentic t4-lysozyme inactivated the in vitro synthesized enzyme. dna from a t4 mutant carrying a deletion in the lysozym ... | 1969 | 4901474 |
| endonucleolytic cleavage of uv-irradiated dna controlled by the v+ gene in phage t4. | 1969 | 4901156 | |
| transcription of the bacteriophage t4 template: strand selection by e. coli rna polymerase in vitro. | 1969 | 4901110 | |
| transcription of bacteriophage t4 deoxyribonucleic acid in vitro. | 1. rna was synthesized in vitro from a template of bacteriophage t4 dna, in the presence of mn(2+). a comparison was made of the rna synthesized by purified rna polymerase from two sources, micrococcus lysodeikticus and escherichia coli; these are referred to as micrococcus crna and e. coli crna respectively (where crna indicates rna synthesized in vitro by using purified rna polymerase and a dna primer). 2. both types of rna were self-complementary as judged by resistance to digestion with ribo ... | 1969 | 4901068 |
| synthesis of early rna in bacteriophage t4-infected escherichia coli b. | 1969 | 4900943 | |
| large-scale preparations of viruses by steric chromatography on columns of controlled pore glass. phi-x174, m13, m12, q-beta and t4 bacteriophages. | 1969 | 4900580 | |
| enzymatic breakage of deoxyribonucleic acid. ii. purification and properties of endonuclease iv from t4 phage-infected escherichia coli. | 1969 | 4900512 | |
| dna replication of phage t4 rii mutants without polynucleotide ligase (gene 30). | 1969 | 4900136 | |
| growth and transformation of phage t4 in escherichia coli b-4, salmonella, aerobacter, proteus, and serratia. | 1969 | 4899052 | |
| the initiation of t4 deoxyribonucleic acid-dependent beta-glucosyltransferase synthesis in vitro. | 1969 | 4899011 | |
| mutator gene studies in escherichia coli. | an escherichia coli mutator gene, mutt, has been shown by p1-mediated crosses to map between the leucine and azide loci. the mutt1 and azi-r alleles cotransduce with a frequency of >92%. in mutt1/mutt(+) merodiploids, the mutt1 phenotype is recessive; in mutt1/f'trp or mutt1/f'lac merodiploids, the mutt1 allele has a trans effect. the gene can mutate lambda and t7 phage but not t1, t3, t4, t5, and s13. | 1969 | 4899001 |
| messenger rna concentration and protein synthesis during t4 infection of escherichia coli b. | 1969 | 4898490 | |
| the effect of genetic complexity on the time-course of ribonucleic acid-deoxyribonucleic acid hybridization. | 1. the rate of rna-dna hybridization was studied under conditions of rna excess, with rna synthesized in vitro. the initial rate of the reaction was proportional to the initial rna concentration. throughout the observed course of the reaction there was a linear relationship between the reciprocal of the amount of rna hybridized/mug. of dna and the reciprocal of time. the slope of the reciprocal plot was inversely proportional to the initial rna concentration. 2. a comparison was made of the hybr ... | 1969 | 4898022 |
| e. coli sigma factor: a positive control element in phage t4 development. | 1969 | 4897820 | |
| freezing of bacteriophage t4: temperature and rate effects as a function of salt concentration. | 1969 | 4897178 | |
| effect of host cell wall material on the adsorbability of cofactor-requiring t4. | the adsorbability of t4 on host cells was determined as a function of time after their liberation from infected cells. freshly liberated (nascent) particles are readily adsorbed but lose their adsorbability with a half-time of about 2 days at 5 c, but only about 20 min at 37 c. they can be made adsorbable again with an alpha-amino acid cofactor like l-tryptophan, and this state of adsorbability can be stabilized by cell wall material from escherichia coli. such stabilized particles lose their ad ... | 1969 | 4897124 |
| on the role of ligase in genetic recombination in bacteriophage t4. | 1969 | 4896157 | |
| initiation factor requirements for the in vitro synthesis of t4 lysozyme. | 1969 | 4896045 | |
| transient activation of rna polymerase in escherichia coli b after infection with bacteriophage t4. | sköld and buchanan(1) have reported that there is a rapid loss of rna polymerase activity in escherichia coli b after infection with t4 bacteriophage. more recent studies on the mechanism of this inactivation have been made in this(2) and other laboratories.(3, 4) in this communication, we report the observation of a transient stimulation of rna polymerase activity when measurement is made immediately after infection and when cells are ruptured by a gentle lysis procedure. the increase in activi ... | 1969 | 4895538 |
| synthesis of phage-specific alpha- and beta-glucosyl transferases directed by t-even dna in vitro. | -bacteriophage t4 dna, when added to a ribonucleic acid- and protein-synthesizing system from uninfected escherichia coli, directed the in vitro synthesis of virus-specific glucosyl transferases. the t4-specific alpha- and beta-glucosyl transferases are synthesized in vivo early after infection, and function to glucosylate the hydroxymethylcytosine residues of phage dna. the in vitro glucosyl transferase synthesis was dependent upon transcription of t4 dna, as well as upon protein synthesis. dna ... | 1969 | 4895217 |
| bacteriophage-induced inhibition of host functions. ii. evidence for multiple, sequential bacteriophage-induced deoxyribonucleases responsible for degradation of cellular deoxyribonucleic acid. | degradation of bacterial deoxyribonucleic acid (dna) after infection with t4 bacteriophage was studied in an endonuclease i-deficient host. the kinetics of degradation were similar to those seen in other hosts with a normal level of this enzyme. irradiation of extracellular phage with ultraviolet (uv) destroyed the capacity of the infecting virus to induce extensive breakdown of host dna, which was, however, converted to high-molecular-weight material. addition of chloramphenicol to t4-infected ... | 1969 | 4894764 |
| events occurring during the replication of bacteriophage t4 dna. | ten temperature-sensitive mutants of t4d have been examined to find the times in the lytic cycle at which a shift to a restrictive temperature no longer exerts a lethal effect. nine of these mutants play a role in phage dna synthesis. the results of these experiments suggest that the products of three of the genes tested-genes 42, 44, and 45-have control or complexing functions in addition to any enzymatic ones. the data also indicate that the products of genes 30 and 41 may act cooperatively. t ... | 1969 | 4894686 |
| dna-dependent rna polymerase from phage t4 infected e. coli: an enzyme missing a factor required for transcription of t4 dna. | 1969 | 4894360 | |
| [synthesis of early phage messengers in escherichia coli infected by t4 during a specific amino acid deficiency]. | 1969 | 4894287 | |
| molecular recombination in the ligase negative t4 amber mutant. | 1968 | 4894254 | |
| kinetics of the alteration and modification of dna-dependent rna-polymerase in t4-infected e. coli cells. | 1969 | 4894028 | |
| studies of deoxycytidylate deaminase from t4-infected escherichia coli. | 1969 | 4893683 | |
| functions of f pili in mating-pair formation and male bacteriophage infection studies by blending spectra and reappearance kinetics. | the extent of removal at various blending speeds (blending spectrum) and the kinetics of reappearance after blending of the ability of male escherichia coli bacteria to form mating pairs, to adsorb and be infected by ribonucleic acid male phage, and to adsorb and be infected by deoxyribonucleic male phage were identical to the blending spectrum and reappearance kinetics of microscopically visible f pili. the same results were obtained with an hfr (high-frequency recombinant), f', or resistance t ... | 1969 | 4892378 |
| initiation and propagation of growing points in the dna of phage t4. | 1968 | 4891989 | |
| dna polymerase and the cell membrane after t4 infection. | 1968 | 4891988 | |
| phage dna synthesis in bacteria infected with t4 light particles. | 1968 | 4891977 | |
| replication and recombination of dna fragments in bacteriophage t4. | 1968 | 4891976 | |
| evidence for a possible direct role of dcmp hydroxymethylase in t4 phage dna synthesis. | 1968 | 4891975 | |
| the function of t4 dna polymerase. | 1968 | 4891974 | |
| repair and recombination in phage t4. ii. genes affecting uv sensitivity. | 1968 | 4891973 | |
| repair and recombination in phage t4. i. genes affecting recombination. | 1968 | 4891972 | |
| studies on the joining of dna by polynucleotide ligase of phage t4. | 1968 | 4891960 | |
| intermediates in t4 dna replication in a t4 ligase deficient strain. | 1968 | 4891959 | |
| site- and gene-specific limited heterocatalytic expression in bacteriophage t4-infected escherichia coli. | genetic evidence for site- and gene-specific variation in limited heterocatalytic expression in phage t4-infected escherichia coli is reported, and the implications of such variation are discussed. | 1969 | 4891752 |
| phospholipid metabolism in t4 bacteriophage infected escherichia coli k-12 (lambda). | infection of escherichia coli k-12 (lambda) by bacteriophage results in an altered labeling pattern of phospholipids in the host cell. although the overall incorporation of (32)p(i) into phospholipids is decreased by infection, the relative amounts of phosphatidylglycerol and cardiolipin are increased. phospholipid changes occurring at later stages in the lytic cycle of infected bacteria are more prominent than those at earlier time intervals. the uptake of (32)p(i) into phospholipids of cells i ... | 1969 | 4891751 |
| enzymatic activities on cell walls in bacteriophage t4. | 1969 | 4891420 | |
| the inability to alter limited heterocatalytic expression in phage t4-infected escherichia coli by growth of host cells under various physiological conditions. | 1969 | 4891414 | |
| the infection of escherichia coli by t2 and t4 bacteriophages as seen in the electron microscope. 3. membrane-associated intracellular bacteriophages. | 1969 | 4891411 | |
| a role for phospholipid hydrolysis in the lysis of escherichia coli infected with bacteriophage t4. | 1969 | 4891410 | |
| unbiased participation of t4 phage dna strands in replication. | 1969 | 4890822 | |
| covalent repair of molecular recombinants in the ligase-negative amber mutant of t4 bacteriophage. | 1969 | 4890770 | |
| bacterial genetic factors controlling the suppression of t4 phage amber mutants. ii. suppression patterns among the segregants of bacterial crosses. | 1968 | 4890345 | |
| bacterial genetic factors controlling the suppression of t4 phage amber mutants. i. suppression patterns of a collection of e. coli strains. | 1968 | 4890344 | |
| loss of lysis inhibition in filamentous escherichia coli infected with wild-type bacteriophage t4. | the plaque enlargement of wild-type t4 bacteriophage observed when assayed in the presence of low concentrations of mitomycin c or after exposure to very low doses of ultraviolet light was studied by using solid as well as liquid culture media. it was found that the filamentous cell formed by the treatment with the agents is responsible for the phenomenon. the filamentous cell was also shown to be characterized not only by the loss of capacity of lysis inhibition but also by a shortening of the ... | 1969 | 4889473 |
| effect of hydroxyurea on replication of bacteriophage t4 in escherichia coli. | hydroxyurea inhibited the replication of bacteriophage t4 in escherichia coli b. the concentration of hydroxyurea required to inhibit net deoxyribonucleic acid (dna) synthesis 50% was about 50-fold less than that required in uninfected cells. even in the presence of high hydroxyurea concentrations, phage dna was readily synthesized from the products of breakdown of the e. coli dna, and viable phage were made. deoxyribonucleotide, but not ribonucleotide, synthesis was strongly inhibited in the pr ... | 1969 | 4889472 |
| control of pyrimidine biosynthesis by phage t4: mutants unable to catalyze the reduction of cytidine diphosphate. | 1969 | 4889429 | |
| separation of t-even bacteriophage deoxyribonucleic acid from host deoxyribonucleic acid by hydroxyapatite chromatography. | a simple and rapid method is described for separation of t-even bacteriophage deoxyribonucleic acid (dna) from host (escherichia coli) dna by hydroxyapatite column chromatography with a shallow gradient of phosphate buffer at neutral ph. by this method, bacteriophage t2, t4, and t6 dna (but not t5, t7, or lambda dna) could be separated from host e. coli dna. it was found that glucosylation of the t-even phage dna is an important factor in separation. | 1969 | 4889266 |
| incorporation and phosphorylation of 5-azacytidine by normal and t4-phage-infected cells of e. coli. | 1969 | 4889173 | |
| a t4 bacteriophage mutant which lacks deoxyribonucleic acid polymerase but retains the polymerase-associated nuclease. | 1969 | 4886429 | |
| in vitro synthesis of t4 proteins. | 1969 | 4886115 | |
| amino acid regulation of messenger ribonucleic acid synthesis in t4-infected escherichia coli. | the effect of amino acid starvation on the synthesis of t4 messenger ribonucleic acid (mrna) was studied by measuring the uptake of labeled precursors into escherichia coli cells which were infected prior to amino acid starvation. the results indicated that the rate of uptake of labeled uracil and adenine into t4 mrna was reduced by approximately 50% when amino acids were withheld from stringent k-12 strains, but not when they were withheld from a stringent strain b or a relaxed strain k-12. chl ... | 1969 | 4884817 |
| enzymatic breakage and joining of deoxyribonucleic acid. iv. dna synthesis in e. coli infected with ligase-negative mutants of phage t4. | 1968 | 4884682 | |
| recovery of uv-inactivated e. coli cells by the v-gene action of phage t4. | 1968 | 4884675 | |
| amino acid control of rna synthesis in t4-infected escherichia coli. | 1968 | 4884582 | |
| studies on the lysozyme from the bacteriophage t4 ejd7ejd4, carrying two frame shift mutations. | 1968 | 4883531 | |
| further studies on the requirement for formyl residues in the synthesis of bacteriophage t4 proteins. | 1968 | 4883326 | |
| inhibition of host protein synthesis during infection of escherichia coli by bacteriophage t4. i. continued synthesis of host ribonucleic acid. | the ribonucleic acid (rna) synthesized at specified intervals during infection of escherichia coli k-12 by bacteriophage t4 was hybridized to denatured e. coli or t4 deoxyribonucleic acids (dna). the reactions were performed under conditions that maximized the yield and at rna/dna inputs such that excess dna sites were available for all rna species. most of the rna synthesized at any time during the first 3 min of infection was host-specific. the fraction declined rapidly as infection progressed ... | 1968 | 4883015 |
| distribution of growing points in dna of bacteriophage t4. | 1968 | 4882615 | |
| [polarity mutation of t4 phage]. | 1968 | 4882392 | |
| mode of action of colicins of types e1, e2, e3, and k. | the effect of colicins on deoxyribonucleic acid and protein synthesis, and also their effect on the ability of t4 phage to replicate in escherichia coli k-12, were studied. colicins of type k inhibited deoxyribonucleic acid synthesis, protein synthesis, and phage growth. among colicins of type e, there was an absolute correlation between mode of action and subdivision into types e(1), e(2), and e(3). | 1968 | 4882019 |
| a structural gene for bacteriophage t4-induced deoxycytidine triphosphate-deoxyuridine triphosphage nucleotidohydrolase. | 1968 | 4881036 | |
| the role of phage lysozyme in the life cycle of phage t4. | 1968 | 4881032 | |
| biochemistry of deoxyribonucleic acid-defective amber mutant of bacteriophage t4. i. ribonucleic acid metabolism. | 1968 | 4880757 | |
| transfer rna coded by the t4 bacteriophage genome. | 1968 | 4880604 | |
| effect of t4 infection on messenger rna synthesis in escherichia coli. | 1968 | 4880561 | |
| phospholipid synthesis in escherichia coli infected with t4 bacteriophages. | after infection of escherichia coli with t4 phage, phospholipid synthesis continued but at a reduced rate. the same phospholipid components were synthesized as in uninfected cells; however, the relative rates of (32)p(i) incorporation into phosphatidylglycerol (pg) and phosphatidylethanolamine (pe) were altered. this alteration was most pronounced during the first 10 min after infection. under these conditions, the isotope incorporated into pg equaled or exceeded that found in pg from uninfected ... | 1968 | 4880428 |
| control of phage and host ribonucleic acid synthesis in phage t4 infected escherichia coli. | 1968 | 4879187 | |
| enzymatic breakage and joining of deoxyribonucleic acid. vi. further purification and properties of polynucleotide ligase from escherichia coli infected with bacteriophage t4. | 1968 | 4879167 | |
| [correlation between filament formation of e. coli and plaque-type changes of bacteriophage t4]. | 1968 | 4878095 | |
| [t4 phage-induced lysozyme dependent e. coli treated with mytomycin c]. | 1968 | 4878093 | |
| coding by t4 phage dna of soluble rna containing pseudouridylic acid. | 1968 | 4877271 | |
| role of polynucleotide ligase in t4 dna replication. | 1968 | 4877007 | |
| influence of t4 on the formation of rna phage-specific polyribosomes and polymerase. | 1968 | 4877003 | |
| studies of dna replication in vivo. 3. accumulation of a single-stranded isolation product of dna replication by conditional mutant strains of t4. | 1968 | 4875804 | |
| metabolism of deoxythymidine 3'-mono- and diphosphate in normal and t4 bacteriophage-infected escherichia coli. | 1968 | 4875414 | |
| nonsense suppression in a multiauxotrophic derivative of escherichia coli 15t-: identification and consequences of an amber triplet in the deoxyribomutase gene. | previously, arginine revertants of escherichia coli wwu, a derivative of e. coli 15t(-), have been subdivided by two independent methods: (i) the streak morphology on nutrient agar, and (ii) the pattern of phage growth using amber and ochre mutants of bacteriophage t4. in the first assay, revertants were subdivided into two classes according to the appearance of streaks after incubation on nutrient agar, a thick, even line of growth defining normal revertants and a thin, irregular line defining ... | 1968 | 4874302 |
| genetic transformation of the bacteriophage t4. i. an outline and some properties of the phage transformation system. | 1968 | 4873560 | |
| genetic transformation of the bacteriophage t4. ii. biological activity of dna fragments. | 1968 | 4873555 | |
| evidence for long dna strands in the replicating pool after t4 infection. | 1968 | 4873341 | |
| inhibition of gamma-ray-induced degradation of e. coli bs-1 dna by infection with t1, t2 and t4 bacteriophage. | 1968 | 4871998 | |
| failure of incomplete t4 genomes to replicate under conditions of single infection. | 1968 | 4871002 | |
| lysis of t4-infected bacteria in the absence of lysozyme. | 1968 | 4871001 | |
| studies on the morphopoiesis of the head of phage t-even. v. the components of the t4 capsid and of other, capsid-related structures. | 1968 | 4870477 | |
| fractionation of the complementary strands of coliphage t4 dna based on the asymmetric distribution of the poly u and poly u,g binding sites. | 1968 | 4870391 | |
| specificity of polyribosomes in the synthesis of t4 bacteriophage head protein. | 1968 | 4870334 | |
| modified dna-dependent rna polymerase from e. coli infected with bacteriophage t4. | 1968 | 4869542 |