Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| synthesis, antiviral and anticancer activity of some novel thioureas derived from n-(4-nitro-2-phenoxyphenyl)-methanesulfonamide. | due to a continuing effort to develop new antiviral agents, a series of 1-[4-(methanesulfonamido)-3-phenoxyphenyl]-3-alkyl/aryl thioureas 3a-i have been synthesized by the reaction of alkyl/aryl isothiocyanates with 4-amino-2-phenoxymethanesulfonanilide. these derivatives were structurally characterized by the use of spectral techniques and evaluated for their anticancer and antiviral activities. none of the tested compounds showed significant anticancer properties on a549 and l929 cell lines. a ... | 2009 | 19324473 |
| prevention of viral sexually transmitted infections--foreskin at the forefront. | 2009 | 19321872 | |
| male circumcision for the prevention of hsv-2 and hpv infections and syphilis. | male circumcision significantly reduced the incidence of human immunodeficiency virus (hiv) infection among men in three clinical trials. we assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (hsv-2) and human papillomavirus (hpv) infections and syphilis in hiv-negative adolescent boys and men. | 2009 | 19321868 |
| regulation of histone deposition on the herpes simplex virus type 1 genome during lytic infection. | during lytic infection by herpes simplex virus type 1 (hsv-1), histones are present at relatively low levels on the viral genome. however, the mechanisms that account for such low levels--how histone deposition on the viral genome is blocked or how histones are removed from the genome--are not yet defined. in this study, we show that histone occupancy on the viral genome gradually increased with time when transcription of the viral immediate-early (ie) genes was inhibited either by deletion of t ... | 2009 | 19321615 |
| prevalence of chlamydia trachomatis and herpes simplex virus 2 in cervical carcinoma associated with human papillomavirus detected in paraffin-sectioned samples. | the aim of the study was to evaluate the frequency of occurrence of hpv and co-infection: chlamydia (c.) trachomatis and hsv-2 in cervical cancer. | 2009 | 19317260 |
| in vitro detection of herpes simplex virus -1 and -2 infection with immunospecific gd3+-cl6-enhanced magnetic resonance imaging. | herpes simplex virus infections are prevalent viral infections in humans. hsvs are also the most common cause of sporadic viral encephalitis (hse). magnetic resonance is the imaging method of choice for hse because it provides the most sensitive method for detecting early lesions. the objective of this study is to set-up and in vitro test an experimental contrast agent specific for antigens present on hsv-infected cells, bound with a paramagnetic agent detectable by mr imaging. a selected anti-h ... | 2009 | 19309561 |
| hiv and other sexually transmitted infections among men, transgenders and women selling sex in two cities in pakistan: a cross-sectional prevalence survey. | the extent and possibilities of spread of the hiv epidemic are not fully understood in pakistan. a survey was conducted among men, women and transgender populations selling sex in rawalpindi (punjab) and abbottabad (north west frontier province) in order to inform evidence-based programme planning. | 2009 | 19307351 |
| genital herpes education and counselling: testing a one-page 'faq' intervention. | approximately 17% of adults in the usa have antibodies to herpes simplex virus type 2 (hsv-2), 85-90% of whom are unaware of their infection. diagnosed patients are more likely to detect hsv reactivation, disclose infection status to partner(s) and employ risk-reduction strategies; therefore, diagnosing more cases may reduce herpes transmission rates. providers are reluctant to identify genital herpes because of potentially lengthy counselling visits or discomfort in dealing with patients' emoti ... | 2009 | 19306603 |
| seroprevalence of herpes simplex virus-2 infection among women seeking medical care for signs and symptoms of vaginitis. | two identically designed studies were conducted to determine the prevalence of herpes simplex virus type 2 (hsv-2) infection and viral shedding among women with no known history of genital herpes or hsv-2 seropositivity, who sought care at a us-based obstetrics/gynaecology clinic because of recurrent signs and symptoms of vaginitis. samples comprised 50 women of any race (all-comers sample; study 1) and 49 black women (black sample; study 2) diagnosed at the clinic visit with vaginitis on the ba ... | 2009 | 19306602 |
| predictors for casual sex and/or infection among sexually transmitted disease clinic attendees in china. | to assess the risk factors for casual sex and infections among the sexually transmitted disease (std) clinic attendees in two disparate chinese cities, an std clinic-based cross-sectional study was conducted to provide demographic and sexual behaviour information. participants were recruited from nine std clinics selected by mapping strategy. std prevalence was 69.4% (68.6% of men and 65.2% of women). the most common diagnoses were non-gonococcal urethritis (22.2%), genital warts (13.2%), syphil ... | 2009 | 19304968 |
| is education the link between orphanhood and hiv/hsv-2 risk among female adolescents in urban zimbabwe? | as the population of orphans grows in aids-affected settings, recent studies describe a heightened risk of hiv and sexual risk behaviours among adolescent orphans compared to their non-orphaned peers. this study explores the role of education in explaining the excess sexual risk previously documented among unmarried female orphans in urban zimbabwe. school attendance and attainment were assessed by type of orphanhood, and for their association with markers of sexual risk (hiv and/or hsv-2 infect ... | 2009 | 19303688 |
| identification of multiple sites suitable for insertion of foreign genes in herpes simplex virus genomes. | information on sites in hsv genomes at which foreign gene(s) can be inserted without disrupting viral genes or affecting properties of the parental virus are important for basic research on hsv and development of hsv-based vectors for human therapy. the intergenic region between hsv-1 ul3 and ul4 genes has been reported to satisfy the requirements for such an insertion site. the ul3 and ul4 genes are oriented toward the intergenic region and, therefore, insertion of a foreign gene(s) into the re ... | 2009 | 19302526 |
| cervical human papillomavirus incidence and persistence in a cohort of hiv-negative women in zimbabwe. | persistent infections with oncogenic human papillomavirus (hpv) types are causally related to cervical cancer. little is known about the distribution of hpv types, independent risk factors of incidence and persistence, and patterns of persistence in sub-saharan africa. | 2009 | 19295468 |
| [impact of low-intensity laser on the suppression of infections caused by herpes simplex viruses 1 and 2: in vitro study]. | the use of low-level laser to suppress infections caused by herpes simplex viruses 1 and 2 was evaluated after one to five applications. a gradual reduction in replication of herpes simplex viruses 1 and 2 was observed, with 68.4% and 57.3% inhibition, respectively, after five applications, thus favoring its clinical use. | 2009 | 19287943 |
| evaluation of chikusetsusaponin iva isolated from alternanthera philoxeroides for its potency against viral replication. | chikusetsusaponin iva and calenduloside e were isolated from the whole plant of alternanthera philoxeroides (mart.) griseb (amaranthaceae) and evaluated for their antiviral activities. chikusetsusaponin iva showed antiviral activities against hsv-1, hsv-2, human cytomegalovirus, measles virus, and mumps virus with selectivity indices (cc (50)/ic (50)) of 29, 30, 73, 25, and 25, respectively. on the other hand, calenduloside e showed no antiviral effects against any of the viruses tested. the mod ... | 2009 | 19277947 |
| impervious. | 2009 | 19272483 | |
| fatal herpes simplex virus type 2 pneumonia in a person with aids. | 2009 | 19271329 | |
| impairment in reactivation of a latency associated transcript (lat)-deficient hsv-2 is not solely dependent on the latent viral load or the number of cd8(+) t cells infiltrating the ganglia. | the hsv latency-associated transcript (lat) is abundantly expressed during virus latency. previous studies have shown that the latent viral load and cd8(+) t cells in ganglia influence the rate of reactivation of hsv. while lat is important for efficient reactivation and establishment of latency, it is uncertain how lat affects either the hsv latent viral load or cd8(+) t cell infiltration of ganglia. we infected mice with lat-deficient or lat-restored hsv-2 at a wide range of inocula. we found ... | 2009 | 19269661 |
| [update on the treatment of genital herpes]. | genital herpes is a chronic infection characterized by periodic reactivation. it can produce symptomatic disease in the host although asymptomatic viral excretion can also occur. it is currently the main cause of genital ulceration and an important public health problem that has substantial clinical, psychological, and economic repercussions. this review analyzes the currently available therapeutic options and regimens, which are based mainly on systemic use of antiviral agents such as aciclovir ... | 2009 | 19268108 |
| hsv-2 icp34.5 protein modulates herpes simplex virus glycoprotein processing. | the icp34.5 gene from hsv-2 strain 333 was cloned and, when expressed in vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein c (gc1), a representative viral glycoprotein, during infection with hsv-1 sp7. the icp34.5 from hsv-1 sp7 limits the extent and efficiency of viral glycoprotein processing. the ability of the hsv-2 icp34.5 protein to enhance the efficiency and extent of hsv-1 sp7 glycoprotein processing indicates that modulation of viral glycoprotein p ... | 2009 | 19267180 |
| the acceptance of hsv-testing partners of hsv-2 seronegative pregnant women. | to estimate the acceptance of hsv testing partners of hsv seronegative pregnant women and identify associated factors. | 2009 | 19265731 |
| seroprevalence of herpes simplex virus 1 and 2 in a population-based cohort in japan. | there have been few population-based studies of the seroprevalence and correlates of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) in japan. | 2009 | 19265271 |
| herpes simplex virus type 2 tegument proteins contain subdominant t-cell epitopes detectable in balb/c mice after dna immunization and infection. | cytotoxic t cells are important in controlling herpes simplex virus type 2 (hsv-2) reactivation and peripheral lesion resolution. humans latently infected with hsv-2 have cytotoxic t cells directed against epitopes present in tegument proteins. studies in mice of immunity to hsv have commonly focused on immunodominant responses in hsv envelope glycoproteins. these antigens have not proved to be an effective prophylactic vaccine target for most of the human population. the murine immune response ... | 2009 | 19264627 |
| herpes simplex virus: incidence of neonatal herpes simplex virus, maternal screening, management during pregnancy, and hiv. | neonatal herpes simplex virus infection is often severe, if not fatal. what is our understanding of the epidemiology of this disease? how is it diagnosed? would maternal screening for herpes simplex virus-2 (hsv-2) in pregnancy make a difference? does maternal hsv alter transmission of hiv vertically or horizontally or both? these questions continue to be pursued and unfortunately, there are few clear answers. | 2009 | 19262380 |
| multiplex pcr testing detection of higher-than-expected rates of cervical mycoplasma, ureaplasma, and trichomonas and viral agent infections in sexually active australian women. | knowing the prevalence of potential etiologic agents of nongonococcal and nonchlamydial cervicitis is important for improving the efficacy of empirical treatments for this commonly encountered condition. we describe four multiplex pcrs (mpcrs), designated vdl05, vdl06, vdl07, and vdl09, which facilitate the detection of a wide range of agents either known to be or putatively associated with cervicitis, including cytomegalovirus (cmv), enterovirus (ev), epstein-barr virus (ebv), varicella-zoster ... | 2009 | 19261782 |
| monitoring of herpes simplex virus in the lower respiratory tract of critically ill patients using real-time pcr: a prospective study. | herpes simplex virus (hsv) has increasingly been associated with pulmonary disease in critically ill patients. however, the clinical relevance of hsv is still a topic of debate. monitoring of hsv in a quantitative way could potentially give relevant information on its role in the pathogenesis of lower respiratory tract infection. a fast and reliable quantitative real-time pcr (q-pcr) for the quantitative detection of hsv-1 and hsv-2 dna was developed. a prospective observational study was perfor ... | 2009 | 19260875 |
| dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: synthesis and biological evaluation of 2,3- and 3,4-dideoxy-3-fluoro-4- and -2-keto-beta-d-glucopyranosyl derivatives of n(4)-benzoyl cytosine. | the synthesis of the dideoxy fluoro ketopyranonucleoside analogues, 1-(2,3-dideoxy-3-fluoro-6-o-trityl-beta-d-glycero-hexopyranosyl-4-ulose)-n(4)-benzoyl cytosine (7a), 1-(3,4-dideoxy-3-fluoro-6-o-trityl-beta-d-glycero-hexopyranosyl-2-ulose)-n(4)-benzoyl cytosine (13a) and their detritylated analogues 8a and 14a, respectively, is described. condensation of peracetylated 3-deoxy-3-fluoro-d-glucopyranose (1) with silylated n(4)-benzoyl cytosine, followed by selective deprotection and isopropyliden ... | 2009 | 19246130 |
| co-infection of herpes simplex virus (hsv) with human immunodeficiency virus (hiv) in women with reproductive tract infections (rti). | in india, hsv seroprevalence and its coinfection with hiv among female patients with reproductive tract infections (rti) are sparse. we aim to ascertain the seroprevalence of hsv and its coinfection with hiv and common sexually transmitted infections attending obstetrics and gynaecology outpatient department, rims. the study included 92 female patients with rti. diagnostic serology was done for hsv-1 and hsv-2 using group specific igm indirect immunoassay using elisa, hiv by 3 elisa/rapid/simple ... | 2008 | 19245157 |
| entry of herpes simplex virus 1 and other alphaherpesviruses via the paired immunoglobulin-like type 2 receptor alpha. | herpes simplex virus 1 (hsv-1) enters cells either via fusion of the virion envelope and host cell plasma membrane or via endocytosis, depending on the cell type. in the study reported here, we investigated a viral entry pathway dependent on the paired immunoglobulin-like type 2 receptor alpha (pilralpha), a recently identified entry coreceptor for hsv-1 that associates with viral envelope glycoprotein b (gb). experiments using inhibitors of endocytic pathways and ultrastructural analyses of chi ... | 2009 | 19244335 |
| prevalence of sexually transmitted infections among pregnant women with known hiv status in northern tanzania. | to determine the prevalence of sexually transmitted infections (stis) and other reproductive tract infections (rtis) among pregnant women in moshi, tanzania and to compare the occurrence of stis/rtis among human immunodeficiency virus (hiv)-infected and uninfected women. | 2009 | 19243592 |
| seroprevalences of herpes simplex virus type 2 and chlamydia trachomatis in turkey. | aim was to detect the seroprevalences of herpes simplex virus type 2 (hsv-2) and chlamydia trachomatis in a subpopulation of turkey. | 2009 | 19242702 |
| update on successes and challenges regarding mother-to-child transmission of hiv. | there is an unprecedented global commitment to reverse the pediatric hiv epidemic by making prevention of mother-to-child transmission (pmtct) services accessible in all countries. this review outlines the successes made and the challenges that remain. | 2009 | 19242245 |
| [computer assessment of an apoptotic process dynamics in the nuclei of placental villi syncytiotrophoblast in puerperas after the outburst of herpes virus infection]. | the development of an apoptotic process in the nuclei of syncytiotrophoblast was studied in the placenta of 50 puerperas, who had the outburst of herpes virus infection in the second part of their pregnancy (antibody titre--1:12800). control group was represented by the placental material obtained from 20 women with no disease. apoptosis was demonstrated in paraffin sections of the material fixed in 10% buffered formalin by in situ labeling of dna fragments (isel-method). the assessment was perf ... | 2008 | 19241877 |
| simultaneous occurrence of pemphigus foliaceus and bullous pemphigoid with concomitant herpesvirus infection. | 2009 | 19236424 | |
| role of nectin-1, hvem, and pilr-alpha in hsv-2 entry into human retinal pigment epithelial cells. | herpes simplex virus-type 2 (hsv-2) can cause acute retinal necrosis (arn), which can lead to exudative and rhegmatogenous retinal detachment, yet little is known about the cellular and molecular mechanisms of hsv-2 entry into retinal pigment epithelial (rpe) cells. the goal of this study was to establish the identity of the critical receptors used by the virus for infection. | 2009 | 19234349 |
| detection of herpes viruses in children with acute appendicitis. | this study aimed to investigate the incidence of herpes simplex virus (hsv) types-1 and -2, varicella-zoster virus (vzv), cytomegalovirus (cmv), epstein-barr virus (ebv), human herpes virus 6 (hhv-6) and human herpes virus 7 (hhv-7) in childhood acute appendicitis. | 2009 | 19233720 |
| viral supraglottitis in an adult. | 2009 | 19224474 | |
| effect of hsv-2 serostatus on acquisition of hiv by young men: results of a longitudinal study in orange farm, south africa. | the objectives of this study were to assess the impact among young men of herpes simplex virus type 2 (hsv-2) status on the acquisition of human immunodeficiency virus (hiv) and on the protective effect of male circumcision against hiv acquisition. | 2009 | 19220143 |
| factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in rakai, uganda. | little is known about risk factors for incident herpes simplex virus type 2 (hsv-2) infection among men in africa. in a trial in rakai, uganda, 6396 men aged 15-49 years were evaluated for serological evidence of hsv-2, human immunodeficiency virus (hiv), and syphilis infections at enrollment and at 6, 12, and 24 months. the prevalence of hsv-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. hsv-2 incidence increased with alcohol use with sexual intercourse (adjusted ... | 2009 | 19220138 |
| dynamic modeling of herpes simplex virus type-2 (hsv-2) transmission: issues in structural uncertainty. | the sexually transmitted infection (sti) herpes simplex virus type-2 (hsv-2) is of public health concern because it is a very common frequently unrecognized lifelong infection, which may facilitate hiv transmission. within hiv/sti modeling, structural uncertainty has received less attention than parametric uncertainty. by merging the compartments of a "complex" model, a "simple" hsv-2 model is developed. sexual interactions between female sex workers (fsws) and clients are modeled using data fro ... | 2009 | 19219511 |
| type i ifn response to papiine herpesvirus 2 (herpesvirus papio 2; hvp2) determines neuropathogenicity in mice. | isolates of baboon alpha-herpesvirus papiine herpesvirus 2 (hvp2) exhibit one of two distinct phenotypes in mice: extremely neurovirulent or apathogenic. previous studies implicated the type i interferon (ifn) response as being a major factor in controlling infection by apathogenic isolates. to further investigate the possibility that the host ifn-beta response underlies the pathogenicity of the two hvp2 subtypes, the susceptibility of mice lacking the ifn-beta receptor (ifnar(-/-)) to infection ... | 2009 | 19215952 |
| beta-androstenes and resistance to viral and bacterial infections. | this report illustrates that the beta-androstenes are indeed able to upregulate the host immune response to a level that enables the host to resist lethal infection by viruses or bacteria. these agents consist of a subgroup of steroids, which also mediates a rapid recovery of hematopoietic precursor cells after whole-body lethal radiation injury. in vivo, the androstenes increase the levels of the th1 cytokines such as il-2, il-3, and ifn. similar to hydrocortisone, they suppress inflammation, b ... | 2009 | 19212128 |
| use of the designation "shedder" in mucosal detection of herpes simplex virus dna involving repeated sampling. | we evaluated two methods to describe detection of herpes simplex virus (hsv) from the genital mucosa. | 2009 | 19211593 |
| intent to accept and acceptance of herpes testing in adolescents and young adults. | understanding the intention-behaviour association with hsv-2 testing is important because it can inform interventions that might be needed to support an effective hsv-2 control programme. this study aims to understand attitudinal, symptomatic and historical precursors to intent to accept, and acceptance of, hsv-2 testing. | 2009 | 19211592 |
| sti prevalence and associated factors among urban men in pakistan. | to measure the prevalence of selected sexually transmitted infections (stis) among urban men in pakistan and identify associated factors. | 2009 | 19211591 |
| cell type specific accumulation of the major latency-associated transcript (lat) of herpes simplex virus type 2 in lat transgenic mice. | we performed in situ hybridization to determine the cell type specific accumulation of the intron of the latency-associated transcript (lat) in tissues in hsv-2 lat transgenic mice in which lat expression is driven by its native promoter. we identified lat in multiple cell types in most tissues analyzed from hsv-2 lat transgenic mice. while weak to moderate signals were seen in brain and spinal cord neurons, epithelial cells, and muscle cells, the strongest signals were detected in neurons from ... | 2009 | 19200567 |
| anti-herpes virus activity of polyether antibiotic cp-44161 in vivo. | in the previous study, we discovered a polyether antibiotic cp-44161, which was reported earlier as an anticoccidal agent, as an anti-varicella zoster virus compound. in this study, we demonstrated that cp-44161 had a very strong and broad anti-herpes virus activities against herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) in vitro. to determine the antiviral activity of cp-44161 in vivo, we examined its effect on the cutaneous hsv-2 infection model in balb/c mice. cp-44161 showed inhibit ... | 2009 | 19198635 |
| transmission probabilities of hiv and herpes simplex virus type 2, effect of male circumcision and interaction: a longitudinal study in a township of south africa. | a synergy between hiv and herpes simplex virus type 2 (hsv-2) infections has been reported in observational studies. the objectives of this study were to estimate the per-sex-act female-to-male transmission probabilities (ftomtps) of hiv and hsv-2, the effect of each infection on the ftomtp of the other and the effect of male circumcision on these ftomtps. | 2009 | 19198042 |
| eight-plex pcr and liquid-array detection of bacterial and viral pathogens in cerebrospinal fluid from patients with suspected meningitis. | we here report on the development of a novel multiplex pcr with product detection in a luminex 100 suspension array system. the assay covers the nine most important bacterial and viral pathogens found in danish meningitis patients. the microorganisms include neisseria meningitidis, streptococcus pneumoniae, escherichia coli, staphylococcus aureus, listeria monocytogenes, streptococcus agalactiae, herpes simplex virus types 1 and 2, and varicella-zoster virus. the study was based on 1,187 samples ... | 2009 | 19193844 |
| index of suspicion. | 2009 | 19188302 | |
| group sex events and hiv/sti risk in an urban network. | to describe: (a) the prevalence and individual and network characteristics of group sex events (gses) and gse attendees; and (b) hiv/sexually transmitted infection (sti) discordance among respondents who said they went to a gse together. | 2008 | 19186355 |
| comparison of cervicovaginal lavage, cervicovaginal lavage enriched with cervical swab, and vaginal tampon for the detection of hiv-1 rna and hsv-2 dna in genital secretions. | we compared the performance of 3 collection methods for cervicovaginal secretions [cervicovaginal lavage (cvl), cvl enriched with a cervical swab (ecvl), and vaginal tampon (vt)] to identify the most reliable method for detection of cervicovaginal hiv-1 and herpes simplex virus type 2 (hsv-2). hiv-1 rna (nuclisens easyq; biomerieux, marcy-l'etoile, france), hsv-2 dna (real-time polymerase chain reaction), and microscopic blood and semen traces were detected in samples from 19 hiv-1-hsv-2-coinfec ... | 2008 | 19186353 |
| herpes simplex virus-2 infection in male rural migrants in shanghai, china. | the overall herpes simplex virus (hsv)-2 seroprevalence was 5.5% among male rural migrants working in construction sites, markets and factories, 5.4% among those reporting having had sexual intercourse and 5.8% among those reporting no sexual intercourse. multiple logistic regression analyses indicate that migrants having higher income were more likely to have hsv-2 infection. none of the hsv-2-positives realized their infection status. future sexually transmitted disease (std) intervention prog ... | 2009 | 19182057 |
| evaluation of three analyte-specific reagents for detection and typing of herpes simplex virus in cerebrospinal fluid. | the performance of three analyte-specific reagents (asrs); cepheid herpes simplex virus (hsv) typing primer probe set (cd), eragen multicode-rtx hsv-1/2 kit primer mix (er), and roche lightcycler hsv-1/2 primer/hybridization probes (rd), was evaluated for detection and typing of herpes simplex virus (hsv-1 and hsv-2) in cerebrospinal fluid (csf) specimens. of 68 csf specimens, hsv-1 was detected in 8 specimens and hsv-2 was detected in 17 specimens. er detected all 25 hsv-positive specimens, whe ... | 2009 | 19179035 |
| [genital herpes]. | genital herpes (gh) is the second leading cause of sexual transmitted disease in women and the third in men. about 40% of female genital herpes is caused by herpes simplex virus type 1 (hsv-1) and the remaining by type-2 (hsv-2). fifty four percent of primary female gh was caused by type-1, whereas 86% of recurrent cases by type-2. for rapid diagnosis of gh, lamp(loop-mediated isothermal amplification), hsv dna nuclear amplification method developed in japan, was applied and favorable results we ... | 2009 | 19177764 |
| [std in the eye]. | in this paper, we review sexually transmitted diseases (std) involving the eye. recently conjunctivitis due to chlamydia trachomatis in children and adults is increasing, and that of neisseria gonorrhoeae resistant to multiple antibiotics has attracted special attention in our country. syphilis has many ocular manifestations such as keratitis, iridocyclitis, retinochorioiditis, and neuritis, etc. ocular complications related to hiv infection, including hiv retinopathy, cytomegalovirus retinitis, ... | 2009 | 19177759 |
| [human immunodeficiency virus/sexually transmitted infection, risk behavior and sexual networks among men who have sex with men in taizhou city, zhejiang province]. | to study the prevalence of human immunodeficiency virus (hiv), sexually transmitted infection (sti), risk behavior and the sexual networks among men who have sex with men (msm) in taizhou city, zhejiang province. | 2008 | 19173880 |
| a molecular method for typing herpes simplex virus isolates as an alternative to immunofluorescence methods. | typing of herpes simplex virus (hsv) isolates is required to identify the virus isolated in culture. the methods available for this include antigen detection by immunofluorescence (if) assays and polymerase chain reaction (pcr). this study was undertaken to standardize a molecular method for typing of hsv and compare it with a commercial if reagent for typing. | 2009 | 19172054 |
| [persistent painful periorificial ulcerations]. | 2009 | 19171237 | |
| hsv suppression reduces seminal hiv-1 levels in hiv-1/hsv-2 co-infected men who have sex with men. | suppressive herpes simplex virus (hsv) therapy can decrease plasma, cervical, and rectal hiv-1 levels in hiv-1/hsv-2 co-infected persons. we evaluated the effect of hsv-2 suppression on seminal hiv-1 levels. | 2009 | 19169140 |
| application of cumulative odds logistic model on risk factors analysis for sexually transmitted infections among female sex workers in kaiyuan city, yunnan province, china. | to investigate the epidemiology of sexually transmitted infections (sti) among female sex workers (fsw) in kaiyuan city, yunnan province, china, and to identify risk factors associated with sti. | 2009 | 19158150 |
| impact of aciclovir on genital and plasma hiv-1 rna in hsv-2/hiv-1 co-infected women: a randomized placebo-controlled trial in south africa. | several studies suggest that herpes simplex virus type 2 (hsv-2) may enhance hiv-1 transmission and disease progression. | 2009 | 19155993 |
| durable protection from herpes simplex virus-2 transmission following intravaginal application of sirnas targeting both a viral and host gene. | a vaginal microbicide should prevent pathogen transmission without disrupting tissue barriers to infection. ideally, it would not need to be applied immediately before sexual intercourse, when compliance is a problem. intravaginal administration of small interfering rna (sirna) lipoplexes targeting herpes simplex virus type 2 (hsv-2) genes protects mice from hsv-2. however, protection is short-lived, and the transfection lipid on its own unacceptably enhances transmission. here, we show that cho ... | 2009 | 19154990 |
| morphofunctional changes in guinea pig ovaries in experimental chronic herpesvirus infection. | the ovaries of adult guinea pigs infected with herpesvirus-2 were examined by light microscopy under conditions of latent infection and relapse of infectious process. morphofunctional changes in the ovarian follicles at all stages of folliculogenesis and in ovarian stroma were caused by the negative effects of type 2 herpes simplex virus. | 2008 | 19145331 |
| [immunohistochemical expression of p16 and herpes simplex virus type 2 in squamous intraepithelial lesions and cervical cancer]. | to demonstrate the expression of biomarkers, detected by immunohistochemical techniques in healthy tissues, as well as in preneoplastic and neoplastic lesions of the uterine cervix. | 2008 | 19142477 |
| serologic detection of herpes simplex virus type 2 antibodies among pregnant women using a point-of-care test from focus diagnostics. | serologic assays that identify herpes simplex type 2 (hsv-2) type-specific antibodies have been commercially available for more than a decade. greater acceptance of these tests is hindered by uncertainty regarding their performance in real-world clinical settings. | 2009 | 19131273 |
| seroprevalence of hsv-2 in hungary and comparison of the hsv-2 prevalence of pregnant and infertile women. | herpes simplex virus type 2 infection is a quite common but frequently asymptomatic, therefore undiagnosed condition. genital hsv-2 infection may cause neonatal herpes, enhances hiv transmission and may play a role in infertility. to evaluate the prevalence of hsv-2 in hungary we tested 2500 serum samples for the presence of anti-hsv-2 igg by elisa method. according to our results hungary belongs to the low-infected countries, the hsv-2 seroprevalence grows with age and is significantly higher a ... | 2008 | 19130750 |
| a genital tract peptide epitope vaccine targeting tlr-2 efficiently induces local and systemic cd8+ t cells and protects against herpes simplex virus type 2 challenge. | the next generation of needle-free mucosal vaccines is being rationally designed according to rules that govern the way in which the epitopes are recognized by and stimulate the genital mucosal immune system. we hypothesized that synthetic peptide epitopes extended with an agonist of toll-like receptor 2 (tlr-2), that are abundantly expressed by dendritic and epithelial cells of the vaginal mucosa, would lead to induction of protective immunity against genital herpes. to test this hypothesis, we ... | 2009 | 19129756 |
| serological diagnosis of human herpes simplex virus type 1 and 2 infections by luciferase immunoprecipitation system assay. | highly quantitative and high-throughput serological tests for evaluation of humoral responses to herpes simplex virus 1 (hsv-1) and hsv-2 are not available. the efficacy of luciferase immunoprecipitation system (lips) assays for antibody profiling and serologic diagnosis of hsv-1 and hsv-2 infection was investigated using a panel of five recombinant hsv antigens. plasma samples from subjects seropositive for hsv-1 and/or hsv-2 or seronegative for hsv-1 and hsv-2 that had previously been analyzed ... | 2009 | 19129469 |
| herpes simplex virus: a histopathologic study of the depth of herpetic wounds. | herpes is a prevalent, infectious disease that can occur anywhere on the body; it is found primarily on the face and genitalia. herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2) are the dna viruses that cause human herpes. clinically, hsv-1 and hsv-2 infections produce lesions generally located on the mucocutaneous junctions of the face and genitalia. at times, vesicular lesions may ulcerate, leaving recalcitrant wounds that are challenging to treat. until now, the basi ... | 2009 | 19126048 |
| hsv-2 induces tlrs and nf-kappab-dependent cytokines in cervical epithelial cells. | herpes simplex virus type 2 (hsv-2) is one of the most common sexually transmitted pathogens worldwide. the host immune response induced by viral infection is cell-type specific. little is known about the innate immune response to this virus in its natural host cells. in this study, we established an in vitro hsv-2 infection model with human cervical epithelial (hce) cells. the viral infection was sufficient to induce expression of toll-like receptors (tlrs), and western blot and reporter assays ... | 2009 | 19124006 |
| cell type-specific induction and inhibition of apoptosis by herpes simplex virus type 2 icp10. | herpes simplex virus (hsv) inhibits apoptosis induced by external stimuli in epithelial cells. in contrast, apoptosis is the primary outcome in hsv-infected lymphocytes. here, we show that hsv type 2 (hsv-2) gene expression appears to be necessary for the induction of apoptosis in jurkat cells, a t-cell leukemia line. hsv-2 icp10 gene expression is sufficient to induce apoptosis in jurkat cells, while its expression protects epithelial hep-2 cells from apoptosis triggered by cycloheximide and tu ... | 2009 | 19116254 |
| risk factors for hiv incidence in women participating in an hsv suppressive treatment trial in tanzania. | a randomized, double-blind, placebo-controlled trial (rct) of herpes simplex virus type 2 suppressive therapy with acyclovir 400 mg twice daily conducted among women in northwestern tanzania reported a similar rate of hiv acquisition in both trial arms (current controlled trials number isrctn35385041). risk factors for hiv incidence were examined in the context of 3-monthly follow-up visits offering both voluntary counselling and testing and care for sexually transmitted infections. | 2009 | 19114859 |
| drug-resistant herpes simplex virus in hiv infected patients. | herpes simplex virus type 2 (hsv2) infection is a major source of morbidity in human immunodeficiency virus (hiv)-infected patients, since reactivations - whether symptomatic or asymptomatic - are associated with increased hiv viral load and viral shedding. acyclovir, valacyclovir and famcyclovir are indicated for the treatment of hsv2 in hiv patients. this class of drugs has been shown to enhance survival in hiv-infected individuals. however, with the emergence of drug-resistant strains of hsv2 ... | 2008 | 19111144 |
| using hepatitis c virus and herpes simplex virus-2 to track hiv among injecting drug users in new york city. | to explore the potential utility of hepatitis c virus (hcv) seroprevalence as a biomarker for injection risk, and herpes simplex virus-2 (hsv-2) as a biomarker for sexual risk among injecting drug users (idus). we examined the relationships between hcv and hiv and between hsv-2 and hiv among injecting drug users in new york city relative to the large-scale implementation of syringe exchange in the mid-1990s. | 2009 | 19108958 |
| hsv-1 genital infection rare in men over the age of 35 years. | 2009 | 19103904 | |
| febrile ulceronecrotic mucha-habermann disease associated with herpes simplex virus type 2. | febrile ulceronecrotic mucha-habermann disease is a rare severe variant of pityriasis lichenoides et varioliformis acuta, a disease within the pityriasis lichenoides spectrum of disorders. it remains uncertain whether these disorders are preneoplastic or reactive against infectious or other antigenic stimuli. febrile ulceronecrotic mucha-habermann disease varies in severity and may be accompanied by a range of systemic symptoms. we present a case associated with herpes simplex virus infection. i ... | 2009 | 19103367 |
| seroprevalence and risk factors for herpes simplex virus infection in a population of hiv-infected patients in canada. | objective:: to determine the seroprevalence of herpes simplex virus infection in a population of hiv-infected individuals in canada. methods:: hiv-infected patients attending 5 infectious disease clinics for follow-up care were approached to participate in the study. after informed consent was obtained, subjects completed a questionnaire documenting hiv-risk behavior, duration of infection, history of oral and/or genital herpes, and treatment for hiv and/or genital herpes. blood for hsv type-spe ... | 2008 | 19098690 |
| mollaret's meningitis caused by herpes simplex virus type 2: case report and review of literature. | 2008 | 19097344 | |
| [comparison of two elisa tests to study the seroprevalence of herpes simplex 1 et 2 infection in a maternity near paris]. | the diagnosis of herpes simplex virus (hsv) genital infection is primarily clinical. the primary indication for serodiagnosis is to detect seronegativity in pregnant women at risk of acquiring the hsv virus during the course of their pregnancy. in this study, two elisa tests were compared for the detection of hsv infection among a population of 307 pregnant women followed at the maternity of a community-based hospital in france (robert ballanger hospital in the seine-saint-denis department). the ... | 2008 | 19091666 |
| population-based prevalence of antibodies against herpes simplex virus type 2 and socio-demographic characteristics in mexico. | although several studies to evaluate the correlates between seroprevalence of herpes simplex virus type 2 (hsv-2) and sexual practices have been carried out with specific groups in mexico, none has evaluated overall seroprevalence among the general population or its relationship with socio-demographic characteristics. the national health survey performed during 2000 in mexico studied a multi-stage, stratified, cluster sample of the general population. characteristics of the adult population, suc ... | 2009 | 19084884 |
| is smoking an independent risk factor for invasive cervical cancer? a nested case-control study within nordic biobanks. | the strong correlation between smoking and exposure to oncogenic human papillomaviruses (hpvs) has made it difficult to verify the independent role of smoking in cervical carcinogenesis. thus, the authors evaluated this role. five large nordic serum banks containing samples from more than 1,000,000 subjects were linked with nationwide cancer registries (1973-2003). serum samples were retrieved from 588 women who developed invasive cervical cancer and 2,861 matched controls. the samples were anal ... | 2009 | 19074773 |
| population-level effect of potential hsv2 prophylactic vaccines on hiv incidence in sub-saharan africa. | herpes simplex virus type-2 (hsv2) infection increases hiv transmission. we explore the impact of a potential prophylactic hsv2 vaccination on hiv incidence in africa using stdsim an individual-based model. a campaign that achieved 70% coverage over 5 years with a vaccine that reduced susceptibility to hsv2 acquisition and hsv2 reactivation by 75% for 10 years, reduced hiv incidence by 30-40% after 20 years (range 4-66%). over 20 years, in most scenarios fewer than 100 vaccinations were required ... | 2009 | 19071187 |
| a serological survey of herpes simplex virus type 1 and 2 immunity in pregnant women at labor stage in tehran, iran. | this study was carried out to determine the prevalence of neutralizing antibodies to herpes simplex virus type 1 (hsv-i) and type 2 (hsv-2) in pregnant women at labor stage. blood samples from umbilical cord of four hundred women aging 16 to 40 years at labor stage were collected. after sera separation quantity of anti hsv-1 and hsv-2 antibodies were measured by serum neutralization test. antibody quantification was assayed by two fold dilution of sera (from 1/2 to 1/256) with 500 tissue culture ... | 2007 | 19070003 |
| amplification and cloning of herpes simplex virus type 2 glycoprotein g from an iranian isolate. | herpes simplex virus type-2 (hsv-2) is the main cause of genital herpes infection. its prevalence is increasing worldwide and varies widely with generally higher rate in developing than developed countries and urban than rural areas. hsv-2 iranian isolate was propagated in hela cell line. the viral genome was extracted by phenol-chloroform and used as template in nested polymerase chain reactions (n-pcr) to amplify gg-2 gene. the amplified gene was cloned into a cloning vector (ptz57r/t) and tra ... | 2007 | 19069897 |
| antiviral activities of extracts from hong kong seaweeds. | we extracted six hong kong brown seaweed species with hot water for their antiviral properties. the cytotoxicity and antiviral activity of these extracts were tested by mtt [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenlytetrezolium bromide] method, cytopathic effect reduction assay, and plaque reduction assay. the antiviral effect was further determined by flow cytometric analysis. the results showed that most of these extracts inhibited the propagation of herpes simplex virus types 1 and 2 (hsv-1 an ... | 2008 | 19067465 |
| evaluation of multiplex real-time pcr for detection of haemophilus ducreyi, treponema pallidum, herpes simplex virus type 1 and 2 in the diagnosis of genital ulcer disease in the rakai district, uganda. | to develop a real-time pcr assay that reliably and accurately detects the predominant sexually transmitted aetiological agents of genital ulcer disease (gud) (haemophilus ducreyi, treponema pallidum and herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2)) and to assess the use of real-time pcr diagnostic testing in a rural african field site. | 2009 | 19066198 |
| fimh adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires tlr4 and type 1 interferon signalling. | components of bacteria have been shown to induce innate antiviral immunity via toll-like receptors (tlrs). we have recently shown that fimh, the adhesin portion of type 1 fimbria, can induce the innate immune system via tlr4. here we report that fimh induces potent in vitro and in vivo innate antimicrobial responses. fimh induced an innate antiviral state in murine macrophage and primary mefs which was correlated with ifn-beta production. moreover, fimh induced the innate antiviral responses in ... | 2008 | 19057665 |
| discontinued drugs in 2007: anti-infectives. | twelve drugs related to therapy and/or prevention of infectious diseases were discontinued from development during 2007. all of these agents were aimed at viral infections, primarily hepatitis c virus (six agents) and hiv (five agents). nearly half were vaccines, including three against hiv, a therapeutic vaccine for hepatitis c, and a vaccine for prevention and treatment of herpes simplex virus type 2. each of these agents is briefly reviewed and the reasons for failure are discussed. | 2009 | 19053877 |
| acute retinal necrosis caused by herpes simplex virus type 2 in a 3-year-old japanese boy. | acute retinal necrosis (arn), which is characterized by rapidly progressing peripheral retinal necrosis, is caused mainly by herpes simplex virus type 1, herpes simplex virus type 2 (hsv-2), or varicella-zoster virus. a previously healthy 3-year-old japanese boy developed arn in his left eye after being bruised by a milk container. hsv-2 dna was detected in the aqueous humor of the affected eye. serological testing suggested that the route of infection was from mother to child, although there wa ... | 2009 | 19050917 |
| tlr2 and tlr9 synergistically control herpes simplex virus infection in the brain. | viruses are recognized by the innate immune system through pattern recognition receptors (prrs). for instance, hsv virions and genomic dna are recognized by tlr2 and tlr9, respectively. although several viruses and viral components have been shown to stimulate cells through tlrs, only very few studies have defined essential roles for single tlrs in innate immune defense in vivo. this could suggest that prrs act in concert to mount the first line of defense against virus infections. to test this ... | 2008 | 19050280 |
| dendritic cells and b cells maximize mucosal th1 memory response to herpes simplex virus. | although the importance of cytotoxic t lymphocytes and neutralizing antibodies for antiviral defense is well known, the antiviral mechanism of th1 remains unclear. we show that th1 cells mediate noncytolytic antiviral protection independent of direct lysis through local secretion of ifn-gamma after herpes simplex virus (hsv) 2 infection. ifn-gamma acted on stromal cells, but not on hematopoietic cells, to prevent further viral replication and spread throughout the vaginal mucosa. importantly, un ... | 2008 | 19047439 |
| chemokines and chemokine receptors critical to host resistance following genital herpes simplex virus type 2 (hsv-2) infection. | hsv-2 is a highly successful human pathogen with a remarkable ability to elude immune detection or counter the innate and adaptive immune response through the production of viral-encoded proteins. in response to infection, resident cells secrete soluble factors including chemokines that mobilize and guide leukocytes including t and nk cells, neutrophils, and monocytes to sites of infection. while there is built-in redundancy within the system, chemokines signal through specific membrane-bound re ... | 2008 | 19043604 |
| persistent and recurring viral infections: the human herpesviruses. | 2009 | 19038775 | |
| vulnerability of women in southern africa to infection with hiv: biological determinants and priority health sector interventions. | to review biomedical determinants of women's vulnerability to infection with hiv and interventions to counter this, within the southern african context. | 2008 | 19033753 |
| functional activity of peritoneal macrophages from sensitive and resistant mouse strains during intravaginal infection with herpes simplex virus type 2 and mucosal vaccination. | in the early period after intravaginal infection with herpes simplex virus type 2 (2 h), macrophages from sensitive dba/2 mice were characterized by higher capacity to engulf the antigen, decreased function of the lysosomal apparatus, lower activity of cathepsin d, and reduced oxygen metabolism compared to cells from resistant balb/c mice. mucosal vaccination with herpes vaccine and hyaluronic acid promoted the increase in functional activity of macrophages and improved survival of sensitive mic ... | 2008 | 19023978 |
| inhibitory activity of melissa officinalis l. extract on herpes simplex virus type 2 replication. | melissa officinalis l. (lamiaceae) (lemon balm) is used in folk medicine for nervous complaints, lower abdominal disorders and, more recently, for treating herpes simplex lesions. in this work the antiviral activity of a hydroalcoholic extract of lemon balm leaves against the herpes simplex virus type 2 (hsv-2) was assessed by the cytopathic effect inhibition assay on vero cells (atcc ccl-81), in comparison with acyclovir. the cytotoxicity of the extract on vero cells was previously tested by ev ... | 2008 | 19023806 |
| comparison of a multiplexed herpes simplex virus type-specific immunoglobulin g serology assay to immunoblot, western blot, and enzyme-linked immunosorbent assays. | the human herpes simplex virus (hsv) is highly pathogenic, with infections caused by two distinct antigenic types, hsv-1 and hsv-2. differentiation of antibodies to these specific antigens can provide useful information for the diagnosis of subclinical or undiagnosed hsv-2 infections, as well as for reducing the risk of maternal transfer of hsv to the neonate. in this study, a multiplex assay capable of concurrent detection of hsv-1 and -2 immunoglobulin g (igg) antibodies was compared to immuno ... | 2009 | 19020107 |
| novel less-abundant viral micrornas encoded by herpes simplex virus 2 latency-associated transcript and their roles in regulating icp34.5 and icp0 mrnas. | we recently identified an acutely and latently expressed viral microrna (mirna), mir-i, encoded by herpes simplex virus 2 (hsv-2) latency-associated transcript (lat) through small rna cloning and two mirnas encoded by hsv-1 lat through prediction. we now report the use of high-throughput sequencing technology to identify two additional relatively less-abundant viral mirnas, mir-ii and mir-iii, encoded by hsv-2 lat exon 2. mir-ii includes two mirnas, mir-ii-5p and mir-ii-3p, which are processed f ... | 2009 | 19019961 |
| differential induction of innate anti-viral responses by tlr ligands against herpes simplex virus, type 2, infection in primary genital epithelium of women. | genital epithelial cells (gecs) are the first line of mucosal defense against sexually transmitted infections. we exploited the ability of gecs to mount innate immune responses, by using tlr ligands to induce anti-viral activity against herpes simplex virus, type 2 (hsv-2). primary cultures of gecs were grown to confluent, polarized monolayers and found to express different levels of mrna for tlr1-10. innate anti-viral responses against hsv-2 infection were determined following treatment with ei ... | 2009 | 19013198 |