Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [propionibacterium acnes infection in patients with csf shunts]. | propionibacterium acnes is a common inhabitant of human skin rarely associated with clinical disease. however it has been recognized as a cause of shunt and postneurosurgical infections. from january 1992 to june 1995, 5,947 cerebrospinal fluid (csf) samples were cultured in our laboratory. we carried out a clinical-epidemiological study in patients where p. acnes was isolated from csf. | 1997 | 9147504 |
| clinical resistance to erythromycin and clindamycin in cutaneous propionibacteria isolated from acne patients is associated with mutations in 23s rrna. | the genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23s rrnas from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible strain. in 13 isolates and the 4 laboratory mutants, cross-resistance to macrolides, lincosamides, and b-type streptogramins was associated with an a-->g transition at a position cognat ... | 1997 | 9145890 |
| chronic propionibacterium acnes endophthalmitis as a cause of intermediate uveitis. | although the pathogenesis in most cases of intermediate uveitis is unknown, a small minority of cases is associated with a variety of specific inflammatory etiologies: sarcoidosis; multiple sclerosis; lyme disease; syphilis; ocular lymphoma; and as a rare manifestation of behçet's disease and aids. a 61-year-old woman developed pars planitis after cataract surgery. a vitrectomy was performed after ten months when a white capsular plaque and an hypopyon developed. propionibacterium acnes was isol ... | 1997 | 9145695 |
| preventive effect of cyclosporin a on experimentally induced acute liver injury in rats. | we examined the effect of cyclosporin a (csa) on the pathogenesis of acute experimental liver injury in rats induced by injection of heat-killed propionibacterium acnes (p. acnes) and subsequent injection of lipopolysaccharide (lps). pretreatment with csa significantly reduced serum alanine aminotransferase (alt), serum tumor necrosis factor-alpha (tnf-alpha) production, without changing the tnf-alpha mrna level in the liver, and plasma interferon-gamma (ifn-gamma), following lps injection in th ... | 1997 | 9138282 |
| tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis. | accumulating evidence implicates tumor necrosis factor (tnf) and fas systems in liver injury, although the interaction between these two systems remains to be investigated. in this study, we examined propionibacterium acnes-primed tnf receptor p55-deficient (tnfrp55-/-) or fas-deficient mrl/mpj lpr/lpr mice challenged with lipopolysaccharide (lps). priming with p. acnes caused mononuclear cell infiltration into the hepatic lobules and granuloma formation in the livers of tnfrp55 wild-type mice. ... | 1997 | 9125577 |
| a retrospective analysis of microbial contaminants in outdated random-donor platelets from multiple sites. | platelet components contaminated with bacteria are an important source of transfusion-associated bacterial sepsis. estimates of contamination rates vary widely (0-10%) and are highly controversial. the present study, designed with stringent testing regimens, retrospectively determined the prevalence of microbial contaminants in platelets from four collection regions. | 1997 | 9122897 |
| bacterial lipopolysaccharide rapidly inhibits expression of c-c chemokine receptors in human monocytes. | the present study was designed to investigate the effect of bacterial lipopolysaccharide (lps) on c-c chemokine receptors (ccr) expressed in human mononuclear phagocytes. lps caused a rapid and drastic reduction of ccr2 mrna levels, which binds mcp-1 and -3. ccr1 and ccr5 mrnas were also reduced, though to a lesser extent, whereas cxcr2 was unaffected. the rate of nuclear transcription of ccr2 was not affected by lps, whereas the mrna half life was reduced from 1.5 h to 45 min. as expected, lps- ... | 1997 | 9120403 |
| cloning and sequencing of the hyaluronate lyase gene from propionibacterium acnes. | the hyaluronate lyase (hyaluronidase) gene from propionibacterium acnes was cloned and sequenced. the gene was isolated on an ecori-generated 3-kb piece of dna. expression was less in escherichia coli than in p. acnes; in e. coli, active enzyme was only cell associated and not secreted. the gene is 2256-pb long and codes for a protein of 82 kda. amino terminal sequencing of the protein of the partially purified gene indicated the presence of a 32-amino-acid leader sequence. the leader sequence s ... | 1997 | 9115089 |
| therapy for acne vulgaris. | 1997 | 9099661 | |
| identification and quantification of bifidobacterium species isolated from food with genus-specific 16s rrna-targeted probes by colony hybridization and pcr. | a bifidobacterium genus-specific target sequence in the v9 variable region of the 16s rrna has been elaborated and was used to develop a hybridization probe. the specificity of this probe, named lm3 (5'-cgggtgcti*cccactttcatg-3'), was used to identify all known type strains and distinguish them from other bacteria. all of the 30 type strains of bifidobacterium which are available at the german culture collection deutsche sammlung von mikroorganismen und zellkulturen, 6 commercially available pro ... | 1997 | 9097423 |
| essential roles of the fas ligand in the development of hepatitis. | the fas ligand (fasl) is expressed in activated t cells and induces apoptosis in fas-bearing cells. a cytotoxic t lymphocyte (ctl) clone specific for hepatitis b surface antigen (hbsag) causes an acute liver disease in hbsag transgenic mice. here we observed that the ctl clone killed hepatocytes expressing hbsag in a fas-dependent manner. administration of the soluble form of fas into hbsag transgenic mice prevented the ctl-induced liver disease. in the second model, mice were primed with propio ... | 1997 | 9095174 |
| [propionibacterium acnes empyema]. | 1997 | 9091110 | |
| protection and therapy of experimental herpesvirus infections in mice with immunomodulating propionibacterium avidum kp-40 and/or acyclovir. | protection and therapy of nmri mice with experimental herpes virus (hsv-1) encephalitis were investigated using heat-killed, lyophilized propionibacterium avidum kp-40 (pa) and/or the herpes-specific antiviral substance acyclovir (acl) as immunomodifier. poly i:c as a potent macrophage activator was used as a reference compound for pa. survival of experimental hsv-1 infections during 18 days following the inoculation of viruses was used for the evaluation of the effects of immunotherapy. the app ... | 1997 | 9084118 |
| immunohistochemical and ultrastructural analyses of in situ activation of hepatic stellate cells around propionibacterium acnes-induced granulomas in the rat liver. | stellate cells embrace the hepatic sinusoids as pericytes. to demonstrate their activation in juxta-sinusoidal location, we induced hepatic granulomatous inflammation, which did not accompany liver injury nor fibrosis, by administrating a low dose (10 mg/kg b.w.) of heat-killed propionibacterium acnes into rats. macrophages and lymphocytes migrated out of the sinusoid and made compact granulomas in the space of disse. stellate cells which faced on the granulomas were closely attached to the sinu ... | 1997 | 9066151 |
| preoperative disinfection of the conjunctival sac in cataract surgery. | conjunctival cultures were obtained from 488 patients undergoing cataract extraction. bacterial isolation rates from the lids and conjunctiva were 84.6 and 36.7, respectively. propionibacterium acnes was the only anaerobic organism identified. a significantly lower incidence of p. acnes was observed in the eyes after preoperative conjunctival irrigation using povidone-iodine solution (9%) compared with those using benzetonium chloride solution (30%). topical use of ofloxacin and cefmenoxime for ... | 1997 | 9065940 |
| propionibacterium acnes in the cortex of patients with alzheimer's disease. | propionibacterium acnes was found in the cortex of three patients with alzheimer's disease and in one frontal cortex of an elderly patient with cardiovascular risk factors and hypoxia due to a large glioblastoma of the right frontal lobe with severely increased intracranial pressure. propionibacterium acnes is an atypical anaerobic bacterium which is sensitive to cephalosporins, but insensitive to metronidazole. it is concluded that a capillary microangiopathy (in consequence of old age and card ... | 1996 | 9063907 |
| enhancement of lung-colonizing potential of murine tumor cell lines co-cultivated with activated macrophages. | in order to explore the influence of activated macrophages on tumor cells, we cultured a series of weakly metastatic clones isolated from the murine t3 fibrosarcoma line (t3 clones) and the b16-f10 melanoma cells on feeder layers of c. parvum- or thioglycollate-elicited macrophages, or 'resident' (unstimulated) macrophages. co-cultivation with c. parvum-elicited macrophages, but not with resident macrophages, induced an increase of the lung-colonizing potential of t3 clones and b16-f10 cells. an ... | 1997 | 9062385 |
| propionebacterium acnes in cultures from ventriculo-peritoneal shunts: infection or contamination? | we have examined the accuracy of our present csf sampling technique in 14 referred patients with suspect shunt dysfunction. the study was performed comparing culture results from shunt reservoir punctures and sham samples from skin tissue fluid close to the reservoirs. propionebacterium acnes (p acnes) was found in five of fifteen cultures from reservoir punctures and in five of fifteen sham procedures. positive cultures correlated in two cases. thirteen of the fourteen patients included in the ... | 1997 | 9059709 |
| propionibacterium avidum sacroiliitis and osteomyelitis. | the anaerobic gram-positive bacterium propionibacterium avidum is a common inhabitant of the skin with low pathogenicity. we report a case of p. avidum sacroilitis, psoas abscess and osteomyelitis in a 67-year-old male who had recently undergone surgical repair of an inguinal hernia. the organism was recovered from blood cultures, a bone biopsy specimen and specimens from the abscess. the spectrum of bone and joint infections caused by propionibacterium is discussed. infection by propionibacteri ... | 1997 | 9051860 |
| presumed noninfectious endophthalmitis after cataract surgery. | to study the clinical features and results of conservative management in cases of presumed noninfectious endophthalmitis after cataract surgery. | 1996 | 9051508 |
| late infection of hand implant after a dental procedure: a case report. | a 78-year-old woman with a silicone implant in her first carpometacarpal joint had acute inflammation and lymphangitis beginning 24 hours after a dental root canal procedure. the infection resolved after implant removal and debridement of the residual carpometacarpal space. although this is a rare event, the use of prophylactic antibiotics to protect implants in the hand should be reviewed. | 1997 | 9040890 |
| activity of eleven kampo formulations and eight kampo crude drugs against propionibacterium acnes isolated from acne patients: retrospective evaluation in 1990 and 1995. | we reviewed the susceptibility of propionibacterium acnes to eleven kampo formulations and to eight kampo crude drugs that had been studied by examining their minimum inhibitory concentrations (mic) in 1990 and 1995. p. acnes strains were most sensitive to oren-gedoku-to (ogt) among these kampo formulations. coptidis rhizoma (cr) and phellodendri cortex (pc) inhibited the growth of p. acnes significantly among the eight kampo crude drugs examined. the patterns of distribution of mic of kampo for ... | 1996 | 9037918 |
| lethal effect of recombinant human fas ligand in mice pretreated with propionibacterium acnes. | fas ligand (fasl) is a type ii membrane protein. binding of fasl to its receptor, fas, induces apoptosis. matrix metalloproteinase cleaves the membrane-bound human fasl to yield the active soluble form. here, we have produced a large amount of human soluble rfasl using the yeast, pichia pastoris. the purified rfasl was found to be glycosylated and to exist as a trimer. the rfasl was effective in inducing apoptosis in a fas-expressing t cell or a fibroblast cell line. the id50 of rfasl for mouse ... | 1997 | 9036978 |
| electrophoresis of whole-cell soluble proteins of microorganisms isolated from bacteremias in endodontic therapy. | we have previously demonstrated that anaerobic bacteria are the microorganisms most frequently isolated from blood following endodontic therapy of teeth with apical periodontitis. phenotypic characterisation of the isolates suggested that the bacteria in the blood originated from the root canal. the present experiment using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) was carried out in an effort to verify these findings, and to further study the microorganisms involved i ... | 1996 | 9021323 |
| bacterial colonization on internal surfaces of brånemark system implant components. | the aim of the present study was to examine the microbiota on the internal surface of the components of 28 brånemark implants in 10 partially edentulous patients who had been treated with 1 fixed partial prostheses each. the prostheses had been in function for 1 to 8 years. the fixed prostheses were checked for mobility and removed. the abutment screws were loosened and classified as stable, easily removed or loose. then, bacterial samples were obtained from the various internal surfaces of the ... | 1996 | 9002826 |
| elevated levels of no in both unchallenged and lps-challenged c. parvum-primed mice are attributable to the activity of a cytokine-inducible isoform of inos. | elevated levels of nitric oxide (no2-/no3-) were detected in the serum of mice 3-7 days after priming with corynebacterium parvum (propionibacterium acnes). the serum no2-/no3- response was completely inhibited when c. parvum-primed (c. parrum) mice were treated with n(g)-monomethyl-l-arginine (l-nmma) or aminoguanidine (ag) on days 6 and 7 post priming. the response was also inhibited when the mice were treated with interleukin-10 (il-10) and the cytokine was most effective when given in multip ... | 1997 | 9000533 |
| activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. | the interleukin-1beta (il-1beta) converting enzyme (ice) processes the inactive il-1beta precursor to the proinflammatory cytokine. ice was also shown to cleave the precursor of interferon-gamma inducing factor (igif) at the authentic processing site with high efficiency, thereby activating igif and facilitating its export. lipopolysaccharide-activated ice-deficient (ice-/-) kupffer cells synthesized the igif precursor but failed to process it into the active form. interferon-gamma and igif were ... | 1997 | 8999548 |
| bacterial immunomodulator olimunostim inhibits degranulation of mastocytes in vitro. | a bacterial immunomodulator olimunostim (os) is one of the first czech biologic response modifiers, which have been introduced into clinical practice. os activates the mechanisms of non-specific immunity and is used for the most part in chronic infections. since os is indicated in patients suffering from infection complicated allergic diseases (asthma bronchiale, atopic eczema, etc.), (1) the concentration of histamine (hi) and hi-like compounds in os, and (2) the possible role of os in the proc ... | 1996 | 8997641 |
| chemical composition of the cell wall of lactic acid bacteria and related species. | in order to examine the relationship between biological activities and the cell wall content, the murein type and the teichoic acid of the cell wall from five strains of bacteria were studied. two of these lactobacillus casei crl 431 and l. acidophilus crl 730, are used in a commercial fermented milk (bio milk), which is believed to be beneficial for health. the other strains, lactococcus lactis crl 526, pediococcus pentosaceus crl 923 and propionibacterium acidipropionici crl 1198 were included ... | 1996 | 8996856 |
| clinical microbiology of coryneform bacteria. | coryneform bacteria are aerobically growing, asporogenous, non-partially-acid-fast, gram-positive rods of irregular morphology. within the last few years, there has been a massive increase in the number of publications related to all aspects of their clinical microbiology. clinical microbiologists are often confronted with making identifications within this heterogeneous group as well as with considerations of the clinical significance of such isolates. this review provides comprehensive informa ... | 1997 | 8993861 |
| molecular cloning of a novel gene, dtsr, which rescues the detergent sensitivity of a mutant derived from brevibacterium lactofermentum. | several strains of corynebacterium and brevibacterium are known for their ability to secrete large amounts of amino acids, especially l-glutamate. we focused on the mechanism of l-glutamate secretion triggered by a detergent, namely polyoxyethylenesorbitan monopalmitate (pesp). a mutant strain, aj11060, derived from brevibacterium lactofermentum atcc 13869 indicates the sensitivity to pesp. a multicopy suppresser gene that compliments the sensitivity of aj11060 to the detergent was derived from ... | 1996 | 8987652 |
| [roles of inflammatory cells in the pathogenesis of acute lung injury in guinea pigs exposed to heat-killed bacteria]. | to study the contribution of polymorphonuclear (pmn) and mononuclear (mn) phagocytes to the development of acute lung injury, we studied lung injury after intratracheal instillation of lipopolysaccharide (0.02 mg/kg) in guinea pigs previously exposed to heat-killed corynebacterium parvum. in on group, cyclophosphamide was given to deplete peripheral pmns. in another group, gadolinium chloride (gdcl3) was injected to suppress the function of mns. four hours after instillation of lippoly soccharid ... | 1996 | 8965395 |
| biosynthesis of vitamin b12: concerning the identity of the two-carbon fragment eliminated during anaerobic formation of cobyrinic acid. | it has been proved that, during anaerobic biosynthesis of the corrin macrocycle, the two-carbon fragment excised from the precursor, precorrin-3, is acetaldehyde, which originates from c-20 and its attached methyl group. this apparently contradictory finding is rationalized in terms of the subsequent enzymatic oxidation of acetaldehyde to acetic acid, which was previously regarded as the volatile fragment released by the action of the biosynthetic enzymes of propionibacterium shermanii. the obse ... | 1996 | 8962048 |
| biosynthesis of vitamin b12: factor iv, a new intermediate in the anaerobic pathway. | the structure of a novel tetradehydrocorrin, factor iv, isolated from propionibacterium shermanii has been established by multidimensional nmr spectroscopy. incorporation of radiolabeled factor iv into cobyrinic acid established the biointermediacy of this cobalt complex, whose structure has implications for the mechanisms of the anaerobic pathway to b12. | 1996 | 8962047 |
| sensitivity of propionibacterium acnes isolated from acne patients: comparative study of antimicrobial agents. | the antimicrobial susceptibility of propionibacterium acnes isolated before and after treatment of acne patients was measured. the four female and three male acne patients were treated with an oral acne medication, roxithromycin or minocycline, and/or a topical acne medication, nadifloxacin cream or clindamycin hydrochloride lotion for 1-8 weeks. the isolated strains were tested for their susceptibility to the antimicrobial action of: nadifloxacin, ofloxacin, erythromycin, clindamycin hydrochlor ... | 1996 | 8959531 |
| use of fura-2/am to measure intracellular free calcium in selenomonas ruminantium. | this paper describes a procedure for loading the acetoxymethyl ester of fura-2 (fura-2/am), and the subsequent measurement of the concentration of intracellular free ca2+ ([ca2+]i) in selenomonas ruminantium (s. ruminantium) using this technique. to ascertain the optimal loading conditions, the effect was examined on the loading of fura-2/am of ethylenediamine-tetraacetic acid (edta), lysozyme, pluronic f127 alone, or the simultaneous application of edta and pluronic f127. individual administrat ... | 1996 | 8944431 |
| corynebacterium parvum- and mycobacterium bovis bacillus calmette-guerin-induced granuloma formation is inhibited in tnf receptor i (tnf-ri) knockout mice and by treatment with soluble tnf-ri. | the aim of this study was to examine the role of tnf receptor i (tnf-ri) in the pathogenesis of heat-killed corynebacterium parvum- and live bacillus calmette-guerin (bcg)-induced granulomas. granuloma formation was analyzed in tnf-ri knockout mice and after treatment with soluble tnf-ri (stnf-ri). tnf-ri knockout mice injected with c. parvum or bcg developed fewer and smaller granulomas than wild-type control mice. mice treated with stnf-ri from days 7 to 13 after injection of c. parvum or bcg ... | 1996 | 8943410 |
| microbial evaluation: 139 implants removed from symptomatic patients. | possible adverse effects of microbial organisms have been implicated in symptomatic silicone implant patients. in the literature, numerous authors have investigated the possible role of infection with respect to implant problems. to date, various bacterial species have been reported, including staphylococcus aureus, staphylococcus epidermidis, peptostreptococci, and clostridium perfringens. infections in polyurethane-coated prostheses also have been shown to prolong morbidity. antibiotic use has ... | 1996 | 8942908 |
| degradation of host protease inhibitors and activation of plasminogen by proteolytic enzymes from porphyromonas gingivalis and treponema denticola. | bacterial proteases may participate in the pathogenesis of periodontal diseases through their action on host proteins. in the present study, the ability of selected periodontopathogens, as well as two proteases isolated from porphyromonas gingivalis and treponema denticola, to degrade host protease inhibitors was evaluated. the activation of human plasminogen by the two bacterial proteases was also investigated. proteolytic breakdown of host protease inhibitors (alpha-1-antitrypsin, antichymotry ... | 1996 | 8936322 |
| mycotic aneurysm after aortic bifurcation prosthesis. | fever in the presence of an intravascular graft will focus the clinical investigation on an infection of this graft. this case report describes an uncommon cause of fever in a 75-year-old patient, namely a mycotic aneurysm of the aortic stump. | 1996 | 8935752 |
| a scanning electron microscopic evaluation of in vitro dentinal tubules penetration by selected anaerobic bacteria. | in vitro root canal dentinal tubule invasion by selected anaerobic bacteria commonly isolated from endodontic infections was evaluated. dentinal cylinders obtained from bovine incisors were inoculated with bacteria, and microbial penetration into tubules was demonstrated by scanning electron microscopy. the results indicated that all bacterial strains tested were able to penetrate into dentinal tubules, but to different extents. | 1996 | 8934991 |
| microbiology of chronic maxillary sinusitis in adults: isolated aerobic and anaerobic bacteria and their susceptibility to twenty antibiotics. | in a comparative study on the efficacy of two surgical treatment procedures, 90 patients diagnosed with chronic maxillary sinusitis received antimicrobial prophylaxis. maxillary sinus fluid samples were taken from these 90 patients before the initiation of antimicrobial prophylaxis, and were cultured for aerobic and anaerobic bacteria. in 81% of all samples, bacterial growth was present. anaerobic bacteria were present in 29% of the cases (5% pure anaerobic and 24% mixed aerobic and anaerobic). ... | 1995 | 8928641 |
| [bacterial flora of acne lesions in diagnostic material of the microbiology and immunology department, pomeranian medical academy (pam) in szczecin]. | a retrospective analysis of the bacterial flora of acne lesions was carried out in 320 patients. atypical flora was isolated very rarely. the pathogenic flora was found most frequently in the autovaccine laboratory when the microbiological material was taken directly onto plates and the investigation was repeated several times. atypical flora was isolated only from three cases. propionibacterium and staphylococcus epidermidis were found to be sensitive to the antibiotics routinely used in the tr ... | 1996 | 8926769 |
| [occurrence of non-spore forming anaerobic bacteria in the upper airways of patients with chronic obstructive pulmonary disease]. | the aim of this study was to assess the occurrence of anaerobic non-sporeforming bacteria upper airways flora in the exacerbation of copd. sputum from 35 copd patients was sent to the laboratory in sterile, filled with co2 containers and cultured under anaerobic conditions. in all patients bacteriological tests were positive. the most common anaerobic bacteria were as follows: peptostreptococcus - in 28 pts, fusobacterium - in 27 pts, bacteroides - in 26 pts and prevotella in 24. less common wer ... | 1996 | 8926767 |
| endocarditis due to propionibacterium granulosum. | 1996 | 8922825 | |
| administration of interleukin-10 at the time of priming protects corynebacterium parvum-primed mice against lps- and tnf-alpha-induced lethality. | several laboratories have described the protective effects of interleukin-10 (il-10) in mouse models of lethal endotoxemia. in most of these experiments, protection was observed in normal mice that were given a lethal dose of lps. however, we failed to observe protection with il-10 in lps-challenged mice that had been primed with corynebacterium parvum (proprionibacterium acnes). we have extended our studies with il-10 in c. parvum-primed mice and in some cases have observed protection that appe ... | 1996 | 8912878 |
| oral administration of a bacterial immunomodulator enhances the immune response to cholera toxin. | attempts to achieve iga responses in the intestine by oral immunization with non replicating antigens have been characterized by ineffective responses of short duration unless long term dosages are administered. cholera toxin (ct) is an exception in that it is able to produce a high secretory and systemic immune response. we study the effects of a bacterial immunomodulator [3 x 10(10) propionibacterium granulosum ml-1 and lipopolysaccharide (lps) 5 mg ml-1] on the immune response to ct orally ad ... | 1996 | 8911015 |
| susceptibility to immunologically mediated fatigue in c57bl/6 versus balb/c mice. | proinflammatory cytokines such as interleukin (il)-1 and tumor necrosis factor (tnf)-alpha have been proposed to play a role in the pathogenesis of fatigue. in the present study we compared the susceptibility of two mouse strains to immunologically induced fatigue. daily running of two strains of mice, balb/c and c57bl/ 6, was assessed after a single injection of corynebacterium parvum antigen (2 mg/mouse). spontaneous running activity of each animal was compared to mean running distance prior t ... | 1996 | 8906747 |
| sub-species discrimination, using pyrolysis mass spectrometry and self-organising neural networks, of propionibacterium acnes isolated from normal human skin. | curie-point pyrolysis mass spectra were obtained from 30 propionibacterium acnes strains isolated from the foreheads of six healthy humans. multivariate analyses and kohonen artificial neural networks (kanns), employing unsupervised learning, were used successfully to discriminate between the p.acnes isolates from different individual hosts. the classification of the isolates by kanns was compared with the more classical multivariate techniques of canonical variates analysis and hierarchical clu ... | 1996 | 8899970 |
| ifn-gamma-inducing factor up-regulates fas ligand-mediated cytotoxic activity of murine natural killer cell clones. | nk cells, non-t non-b immune effector lymphocytes, are localized in many organs, including liver, as well as in the circulation. to investigate the regulatory mechanism of killing apparatus in hepatic nk cells, we established il-2-dependent nk cell clones from liver lymphocytes of balb/c nude mice. to generate the nk cell clones, we incubated liver lymphocytes with a high dose of il-2 in the presence of irradiated kupffer cells, as feeder cells and as the source of il-12, originally identified a ... | 1996 | 8892629 |
| in vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms. | the antibacterial activities of nitazoxanide and its main metabolite, tizoxanide, were tested against a broad range of bacteria, including anaerobes. metronidazole, amoxicillin, amoxicillin-clavulanic acid, piperacillin, cefoxitin, imipenem, and clindamycin were used as positive controls. mics were determined by reference agar dilution methods. the 241 anaerobes were all inhibited by nitazoxanide, with the mics at which 90% of isolates are inhibited (mic90s) being between 0.06 and 4 mg/liter wit ... | 1996 | 8891127 |
| homology modeling of human methylmalonyl-coa mutase: a structural basis for point mutations causing methylmalonic aciduria. | point mutations in the human gene encoding coenzyme b12 (adenosylcobalamin)-dependent methylmalonyl-coa mutase give rise to an inherited disorder of propionic acid metabolism termed mut methylmalonic aciduria. almost all such mutations alter amino acids in the homodimeric human enzyme that are identical to residues in the catalytic alpha-subunit of the heterodimeric methylmalonyl-coa mutase from the bacterium propionibacterium shermanii, to which the mature human enzyme shows an overall 65% sequ ... | 1996 | 8880917 |
| intervertebral diskitis caused by propionibacterium acnes: a report of four cases. | 1996 | 8879798 | |
| fed-batch fermentation with and without on-line extraction for propionic and acetic acid production by propionibacterium acidipropionici. | fed-batch propionic and acetic acid fermentations were performed in semi-defined laboratory medium and in corn steep liquor with propionibacterium acidipropionici strain p9. on average, over four experiments, 34.5 milligrams propionic acid and 12.8 milligrams acetic acid were obtained in about 146 h in laboratory medium with 79 milligrams glucose added over five feeding periods. the highest concentration of propionic acid, 45 milligrams, was obtained when the glucose concentration was not allowe ... | 1996 | 8867628 |
| influence of hemodilution on cefuroxime levels and bacterial contamination of intra- and postoperative processed wound blood during hip replacement. | materials and methods: in a prospective randomized study we investigated the effect of hemodilution on cefuroxime levels and bacterial contamination of processed shed blood during hip arthroplasty. 10 patients received cefuroxime 1,5 g as single shot prophylaxis before (group a), 10 after hemodilution (15 ml/kg) (group b). cefuroxime levels in serum 1 h after administration, at the end of operation, after 12 h and in drainage-blood after 12 h were assessed by hplc. bacteriological study was perf ... | 1996 | 8865946 |
| experimental extrinsic allergic alveolitis and pulmonary angiitis induced by intratracheal or intravenous challenge with corynebacterium parvum in sensitized rats. | extrinsic allergic alveolitis and pulmonary sarcoidosis are granulomatous diseases of the lung for which clinical presentation and anatomic site of granuloma formation differ. extrinsic allergic alveolitis is caused by inhaled antigens, whereas the nature and source of the inciting antigen in sarcoidosis is unknown. to test the hypothesis that the route via which antigen is introduced to the lung contributes to the clinicopathological presentation of pulmonary granulomatous disease, rats immuniz ... | 1996 | 8863677 |
| protective effect of celosian, an acidic polysaccharide, on chemically and immunologically induced liver injuries. | hepatoprotective effect of celosian, an acidic polysaccharide isolated from the water extract of the seed of celosia argentea, was investigated using chemical and immunological liver injury models. celosian inhibited the elevation of serum enzyme (gpt, got, ldh) and bilirubin levels on carbon tetrachloride (cc1(4))-induced liver injuries in rat. in addition, the hepatoprotective effect of celosian was also observed in this model of liver injury by histopathological findings. moreover, celosian s ... | 1996 | 8860960 |
| infection of a total knee joint prosthesis by peptostreptococcus micros and propionibacterium acnes in an elderly ra patient: implant salvage with longterm antibiotics and needle aspiration/irrigation. | we describe the favourable long-term outcome after late total knee joint prosthesis infection in an elderly ra patient. peptostreptococcus micros and propionibacterium acnes were cultured from the synovial fluid, and the finding of a coexistent abscess at the root of a wisdom tooth suggested a dental origin to the joint infection. long-term antibiotics in conjunction with aspiration/irrigation resulted in salvage of the implant and an excellent functional outcome. | 1996 | 8853177 |
| the masked cysteine residues in methylmalonyl-coa mutase from propionibacterium shermanii are essential for catalytic activity. | two masked cysteine residues have been reported in methylmalonyl-coa mutase from propionibacterium shermanii, cys-535 in the alpha-subunit and cys-517 in the beta-subunit, which are revealed only after reduction of the denatured enzyme with dithiothreitol. it has been postulated that these residues are involved in disulphide linkages to unknown thiols of low m(r). these two masked cysteine residues have been changed to an alanine, individually. both the mutants, c535alphaa and c517betaa, were in ... | 1996 | 8843148 |
| orbital infections in patients with human immunodeficiency virus infection. | opportunistic infections frequently involve the anterior and posterior segments of the eye but rarely occur in the orbit in patients with human immunodeficiency virus (hiv) infection. the authors managed eight patients with hiv and unilateral orbital infections who presented between july 1988 and march 1995. | 1996 | 8841310 |
| role of ifn gamma on tnf alpha, il-1 beta and il-6 release during hhv-6 infection. | the release of monokines such as tumor necrosis factor a (tnf alpha), interleukin-1 beta (il-1 beta) and interleukin-6 (il-6) by activated monocytes/macrophages is an important step in the immune as well as in the inflammatory response. in this study the production of tnf alpha, il-1 beta and il-6 by human monocytes (hm) and peripheral blood mononuclear cells (pbmc) was evaluated after hhv-6 infection. our results demonstrate that hhv-6 can selectively regulate monokine synthesis, in a time-depe ... | 1996 | 8841033 |
| influence of propionibacterium avidum kp-40 on the cellular immune system after intensive sport activity. | intensive sport activities resulted in temporary downregulation of defined immune functions. to check its influence on the cellular immune system, 15 male professional ice hockey players of a german first league club were observed and a decrease of lymphocyte subset counts and activities was found after anaerobic exercise. to stabilize cellular immune functions, the players were orally treated with propionibacterium avidum kp-40 (10 mg per administration; twice a day; 7 days), a well documented ... | 1996 | 8837397 |
| an identification scheme for rapidly and aerobically growing gram-positive rods. | an identification scheme for aerobically growing gram-positive rods (genera actinomyces, arcanobacterium, aureobacterium, bacillus, brevibacterium, cellulomonas, corynebacterium, dermabacter, erysipelothrix, gardnerella, lactobacillus, listeria, microbacterium, oerskovia, propionibacterium, rhodococcus, rothia, turicella, as well as unnamed cdc groups, clostridium tertium, and mycobacterium fortuitum/chelonae) is presented. it is derived from the hollis-weaver scheme and uses catalase, oxidative ... | 1996 | 8837385 |
| application of direct-fed microbial bacteria and fructooligosaccharides for salmonella control in broilers during feed withdrawal. | providing direct-fed-microbial (dfm) bacteria and fructooligosaccharides (fos) for the control of potential escalation of salmonella colonization during simulated feed withdrawal and confinement was assessed. eight hundred and eighty broilers (16 pens; 55 chicks per pen) were reared to 6 wk of age. chicks were sprayed with a solution containing 10(6) nalidixic-acid resistant salmonella typhimuriumnr cells per milliliter on the 2nd d after hatching. because this first challenge did not yield a hi ... | 1996 | 8833368 |
| critical comments on "propionibacterium acnes in the cortex of patients with alzheimer's disease" by h.h. kornhuber (eur arch psychiatry clin neurosci, 1996, 246:108-109) | 1996 | 8832202 | |
| propionibacterium acnes isolated from sternal osteitis in a patient with sapho syndrome. | a woman presented with palmar pustulosis and deep chest pain in association with osteitic lesions in the lower part of the sternum. propionibacterium acnes was isolated and grew in pure culture from 6 surgically obtained bone specimens. the patient received clindamycin treatment for 6 months. synovitis in both her wrists persisted and, based on a clinical suspicion of seronegative rheumatoid arthritis, she was treated with intramuscular gold and methotrexate with no apparent benefit. subsequentl ... | 1996 | 8823714 |
| failure of gram stain to detect propionibacterium acnes in specimens from clinically significant infections. | 1996 | 8818915 | |
| susceptibility testing of propionibacterium acnes comparing agar dilution with e test. | propionibacterium acnes has been identified as a significant agent of nosocomial infections, including endophthalmitis. data concerning susceptibility of p. acnes to newer beta-lactam antibiotics and fluoroquinolones are limited. recent reports suggest that quinolones have activity against these organisms sufficient to warrant further study. we undertook a study to select appropriate antimicrobial agents for use in a rabbit model of p. acnes endophthalmitis. we compared the antibiotic susceptibi ... | 1996 | 8815076 |
| how coenzyme b12 radicals are generated: the crystal structure of methylmalonyl-coenzyme a mutase at 2 a resolution. | the enzyme methylmalonyl-coenzyme a (coa) mutase, an alphabeta heterodimer of 150 kda, is a member of a class of enzymes that uses coenzyme b12 (adenosylcobalamin) as a cofactor. the enzyme induces the formation of an adenosyl radical from the cofactor. this radical then initiates a free-radical rearrangement of its substrate, succinyl-coa, to methylmalonyl-coa. | 1996 | 8805541 |
| coexpression of interleukin-4 and b7.1 in murine tumor cells leads to improved tumor rejection and vaccine effect compared to single gene transfectants and a classical adjuvant. | to improve the vaccine potency of gene-modified tumor cells, using retroviruses, we have expressed the b7.1 gene in j558l cells and a subline previously transfected with the gene for interleukin-4 (il-4). complete longterm tumor eradication occurred in only 73-82% of syngeneic balb/c mice injected with il-4 or b7.1 transfectants or tumor cells mixed with the adjuvant corynebacterium parvum. in contrast, none of the mice injected with j558-il4/b7.1 cells developed a tumor, thus demonstrating that ... | 1996 | 8800747 |
| postoperative subdural empyema caused by propionibacterium acnes--a report of two cases. | two patients with postoperative subdural empyema following burr hole evacuation of chronic subdural haematoma are reported, both caused by propionibacterium acnes. the need to consider this diagnosis in patients developing recurrent symptoms after surgical drainage of chronic subdural haematoma is emphasized. | 1996 | 8799549 |
| iron chelates bind nitric oxide and decrease mortality in an experimental model of septic shock. | the hydroxamic acid siderophore ferrioxamine b [feiii(hdfb)+] and the iron complex of diethylenetri-aminepentaacetic acid [feiii(dtpa)2-] protected mice against death by septic shock induced by corynebacterium parvum + lipopolysaccharide. although feiii(dtpa)2- was somewhat more effective than feiii(hdfb)+, the iron-free ligand h4dfb+ was significantly more effective than dtpa. the hydroxamic acid chelator has a much higher iron affinity than the amine carboxylate, allowing for more efficient fo ... | 1996 | 8799167 |
| tritium isotope effects in adenosylcobalamin-dependent methylmalonyl-coa mutase. | methylmalonyl-coa mutase from propionibacterium shermanii is an adenosylcobalamin-dependent enzyme which catalyzes the reversible isomerization of methylmalonyl-coa and succinyl-coa. the rate of tritium loss from 5'-[3h]adenosylcobalamin during the enzymic reaction and the relative rates of tritium appearance in substrate and product were examined. upon the addition of methylmalonyl-coa to a solution of holoenzyme, tritium was completely released from the cofactor within about 500 ms. no tritium ... | 1996 | 8794760 |
| microbiology of acute purulent pericarditis. a 12-year experience in a military hospital. | to study the aerobic and anaerobic micro-biological and clinical characteristics in 15 cases of acute pericarditis treated over a 12-year period. | 1996 | 8790081 |
| rapid characterization of periodontal bacterial isolates by using fluorogenic substrate tests. | eighty-nine species of subgingival bacteria, represented by 121 reference strains and 892 patient isolates, including gram-negative, gram-positive, aerobic, facultatively anaerobic, microaerophilic, and anaerobic species, were characterized with a panel of fluorogenic, 4-methylumbelliferyl-linked substrate tests. identifications of all patient isolates were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) of whole-cell proteins relative to reference strains. char ... | 1996 | 8789019 |
| bacteria and antimicrobial agents in the treatment of acne. | 1996 | 8786181 | |
| immunohistochemical localization of nitric oxide synthases. | 1996 | 8782617 | |
| [sepsis following autologous blood transfusion]. | postoperatively, after an uncomplicated vaginal hysterectomy, a 58-year-old female patient developed the signs of disseminated intravascular coagulation and fever, which progressed to a septic shock. she received two units of autologous blood, one during and one after the operation. a blood culture from the patient and one unit of the autologous blood showed abundant growth of pseudomonas cepacia and serratia marcescens within 24 h and culture of this blood bag also showed slight growth of staph ... | 1996 | 8779406 |
| propionibacterium granulosum activities in rats during the muscle phase of trichinella spiralis invasion. | immune response of wistar rats, infected with 4000 l1 t. spiralis and treated with p. granulosum during the muscle phase of nematode invasion were measured. the increase of spleen mass was observed in all groups infected and exposed to p. granulosum. intraperitoneal injection of bacteria results in higher level of t lymphocytes and activated neutrophils. the level of inhibition of macrophages migration was depended on relation to the time and doses of injection. in non-specific stimulated animal ... | 1996 | 8755145 |
| kinetics of nitric oxide synthase induction by propionibacterium avidum and lipopolysaccharide. | conditions for the induction of rat liver ca2(+)-independent nitric oxide synthase were determined with killed propionibacterium avidum, and compared with lipopolysaccharide endotoxin. similar maximal induction was obtained intraperitoneally with the two types of inducers but killed propionibacterium avidum gave a long-lasting induction while lipopolysaccharide displayed a rapid and short response. moreover, the induction resulting from an intravenous administration of killed propionibacterium a ... | 1995 | 8748697 |
| protective effects of macrophage-derived interferon against encephalomyocarditis virus-induced diabetes mellitus in mice. | the involvement of macrophages in protection against diabetes mellitus in mice of balb/c (susceptible) and c57bl (resistant) strains infected with the b (non-diabetogenic) or d (highly diabetogenic) variant of encephalomyocarditis (emc) virus was examined. pretreatment with the b variant of emc virus (emc-b), avirulent interferon (ifn) inducer, or corynebacterium parvum inhibited diabetes in balb/c mice infected with the d variant of emc virus (emc-d). treatment of c57bl mice with carrageenan to ... | 1995 | 8746525 |
| rapid formation of multicellular spheroids composed of propionibacterium acnes pretreated adult rat liver cells by rotary culture and their immunological properties. | an experimental acute liver injury model can be produced by the injection of bacterial lipopolysaccharide (lps) into propionibacterium acnes (p. acnes) pretreated rats. the massive liver cell necrosis is estimated by elevation of serum transaminase activities. in this study, we produced this necrosis in an in vitro model by using primary co-cultured rat liver cells. a novel method for the preparation of spheroids consisting of p. acnes pretreated parenchymal and nonparenchymal liver cells has be ... | 1995 | 8746484 |
| the effects of acne treatment with a combination of benzoyl peroxide and erythromycin on skin carriage of erythromycin-resistant propionibacteria. | concomitant application of 5% w/w benzoyl peroxide and 3% w/w erythromycin has previously been shown to prevent the overgrowth, on the skin of acne patients, of erythromycin-resistant coagulase-negative staphylococci, which occurs when the antibiotic is used alone. two in vivo studies were carried out to assess the ability of the same therapeutic combination to inhibit the growth of pre-existing erythromycin-resistant propionibacteria and to prevent the selection of resistant strains during trea ... | 1996 | 8745894 |
| [search for bacterial contamination of the aqueous humor during cataract surgery with and without local antibiotic prophylaxis]. | bacterial contamination of anterior chamber at the end of cataract surgery, was compared between two techniques: extracapsular extraction and phacoemulsification. the effectiveness of preoperative antibiotic eyedrops using norfloxacine 0.3% (chibroxine) was also evaluated. | 1995 | 8745762 |
| bacterial contamination of autologous bone marrow during processing. | as part of an audit of the processing of autologous bone marrow, we found that marrow was often contaminated with organisms potentially pathogenic to neutropenic recipients. one of 14 marrows studied was found to be contaminated before the processing stage and five others became contaminated during processing. the organisms isolated at these stages were propionibacterium sp., coagulase-negative staphylococci, staphylococcus aureus and coryneforms, suggesting that the skin was the likely source o ... | 1996 | 8738204 |
| the reactivity of b12 cofactors: the proteins make a difference. | determination of the structure of intact methylmalonyl-coa mutase from propionibacterium shermanii, and comparisons with the structure of the cobalamin-binding fragment of methionine synthase from escherichia coli, afford a first glimpse at the similarities and distinctions between the two principal classes of b12-dependent enzymes: the mutases and the methyltransferases. | 1996 | 8736549 |
| [positive corneal findings of propioni bacterium acnes and keratitis]. | propioni bacterium acnes may be isolated from corneal specimens. its presence usually evokes a neighbouring tissue contamination. nevertheless we have tried to find arguments in favour of a possible pathological responsibility of this microorganism in corneal affections. | 1996 | 8729835 |
| oxytetracycline-mediated alteration of murine immunocompetence. | the immunomodulatory effect of oxytetracycline (otc) on murine splenic lymphocytes (msl), peritoneal exudate macrophage (pem) functions and antibody production was examined. in vivo exposure to otc slightly delayed initiation of antibody formation during the primary response. however, otc exposure had no effect on either the peak time of antibody response or peak antibody titer. otc also had no significant effect on the secondary antibody response. mitogen-induced proliferation of msl cocultured ... | 1995 | 8724209 |
| effect of silica treatment on resistance to babesia rodhaini infection in immunized mice. | the effect of silica treatment on the course of babesia rodhaini infection was investigated in icr mice pretreated with either a mixture of b. rodhaini parasitized red blood cell hemolysation-sonication (s) antigen and propionibacterium acnes bacterin or p. acnes bacterin alone and not subjected to immunization. in the normal mice (non-immunized), the mean survival time was decreased by approximately 1 day when 5 mg per mouse of silica were intraperitoneally inoculated at 5 h before infection. i ... | 1996 | 8720558 |
| salivacin 140, a novel bacteriocin from lactobacillus salivarius subsp. salicinius t140 active against pathogenic bacteria. | fifteen of 353 environmental isolates of lactic acid bacteria consistently showed activity against listeria monocytogenes, streptococcus mutans, actinomyces viscosus, and/or propionibacterium acnes. strain t140, isolated from the surface of japanese pampas grass leaves and identified as lactobacillus salivarius subsp. salicinius, also had activity against several lactobacillus species, staphylococcus aureus and yersinia enterocolitica. since the antagonistic factor(s) produced by t140 was sensit ... | 1996 | 8695066 |
| singlet oxygen (1 delta g) generation from coproporphyrin in propionibacterium acnes on irradiation. | although singlet oxygen has been postulated to be a highly reactive and toxic intermediate, there has been no evidence of considerable generation of singlet oxygen in vivo level except for special cases. in this work, we firstly measured the near-infrared emission spectra corresponding to the o2(1 delta g) --> o2(3 epsilon g-) transition of singlet oxygen of cutaneous propionibacterium acnes (p. acnes) porphyrin under laser excitation. a comparison of the singlet oxygen production of coproporphy ... | 1996 | 8687438 |
| [current treatment strategy in malignant pleural effusion]. | malignant pleural effusions are a grave consequence of advanced cancer disease. the successful suppression of pleural fluid reaccumulation can make a major contribution to the management and palliative care of patients with disseminated cancer. many treatment concepts have been reported in the literature. the recommended therapy in malignant pleural effusions consists of intrapleural instillation of a sclerotic agent to produce pleurodesis. different substances have been used, including tetracyc ... | 1996 | 8686317 |
| fluorescence photography in the evaluation of acne. | quantification of acne remains a challenge. it may be difficult to identify lesions by standard flash photography. previous studies have shown that foci of light in fluorescence photographs correspond to high protoporphyrin ix production by propionibacterium acnes in open comedones, follicles, and inflammatory lesions. | 1996 | 8682965 |
| in vitro activity of mdl 62,879 against gram-positive bacteria and bacteroides species. | the new thiazolyl peptide antibiotic mdl 62,879 (ge2270 a) showed excellent in vitro activity in testing against staphylococci and streptococci, with mic90s ranging from 0.23 to 0.9 mg/l. it was very active against clostridium difficile and propionibacterium acnes (mic90 0.06 mg/l in each case) and had variable activity against bacteroides spp. mdl 62,879 had exceptionally good activity against enterococcus faecalis, including against a collection of high-level aminoglycoside-resistant isolates ... | 1995 | 8681991 |
| anti-lipase activity of kampo formulations, coptidis rhizoma and its alkaloids against propionibacterium acnes. | anti-lipase activity of kampo formulations, coptidis rhizoma (cr), and its alkaloids against propionibacterium acnes were examined in vitro. the amounts of propionic and butyric acids in the medium were measured as growth and lipase activity of p. acnes, respectively. in tributyrin-pyg medium with each concentration of kampo formulation, cr, or the alkaloids added, the production of propionic acid was suppressed remarkably more than that of butyric acid. the suppression of production of these ac ... | 1996 | 8675819 |
| a pivotal role of il-12 in th1-dependent mouse liver injury. | intravenous injection of propionibacterium acnes and lipopolysaccharide (lps) with a 7 day interval caused cd4+ t cell-dependent severe liver injury in the c57bl/6 (h-2b) mouse strain. in contrast, balb/c (h-2d) mice were resistant to p. acnes and lps-induced liver injury. the different susceptibilities of the two mouse strains to liver injury appeared to be closely correlated with their different abilities to produce ifn-gamma after p. acnes priming. namely, the sensitive c57bl/6 mouse strain p ... | 1996 | 8671644 |
| bacterial contamination of anaerobic vitreous cultures: using techniques employed for endophthalmitis. | to investigate the occurrence of contaminated cultures of vitreous specimens from non-infected eyes obtained using anaerobic techniques employed for endophthalmitis. | 1996 | 8670775 |
| the in vitro activity of trospectomycin against anaerobic bacteria. | the authors evaluated the activity of trospectomycin, a new aminocyclitol which is characterized by good antibacterial and broad spectrum activity, in comparison with clindamycin and ampicillin on a sample of recent isolates: bacteroides fragilis (15 strains), bacteroides urealyticus (5 strains), bacteroides vulgatus (5 strains), bacteroides spp. (15 strains), prevotella melaninogenica (6 strains), porphyromonas asaccharolytica (7 strains), mobiluncus spp. (3 strains), peptococcus niger (3 strai ... | 1995 | 8667035 |
| corynebacterium parvum versus tetracycline as pleural sclerosing agents in rabbits. | tetracycline has been one of the most commonly used agents for producing a pleurodesis. however, it is no longer available due to more stringent requirements on the manufacturing process. the objective of this project was to determine whether corynebacterium parvum is an effective sclerosant in an experimental model in rabbits. the following medications were instilled intrapleurally in anaesthetized male rabbits: tetracycline 35 mg.kg-1 or c. parvum 4 or 8 mg, all diluted with bacteriostatic sal ... | 1995 | 8666113 |
| exafs investigation of the active site of iron superoxide dismutase of escherichia coli and propionibacterium shermanii. | the local structure of the iron site in ferric superoxide dismutase from p. shermanii was analyzed by x-ray absorption spectroscopy. the metal-ligand cluster of the enzyme is found to be similar to the crystallographically investigated ferric superoxide dismutase from e. coli. at ph 6.4 the enzyme is five-fold coordinated with three histidines, an aspartate and a water molecule. the average bond lengths between the metal and the histidines are about 2.10 a, between metal and aspartate they are a ... | 1996 | 8665837 |