Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| sexually transmitted infections, bacterial vaginosis, and candidiasis in women of reproductive age in rural northeast brazil: a population-based study. | population-based data on sexually transmitted infections (sti), bacterial vaginosis (bv), and candidiasis reflect the epidemiological situation more accurately than studies performed in specific populations, but such data are scarce. to determine the prevalence of sti, bv, and candidiasis among women of reproductive age from a resource-poor community in northeast brazil, a population-based cross sectional study was undertaken. all women from seven hamlets and the centre of pacoti municipality in ... | 2007 | 17924006 |
| the value of including boys in an hpv vaccination programme: a cost-effectiveness analysis in a low-resource setting. | we assessed the cost-effectiveness of including boys vs girls alone in a pre-adolescent vaccination programme against human papillomavirus (hpv) types 16 and 18 in brazil. using demographic, epidemiological, and cancer data from brazil, we developed a dynamic transmission model of hpv infection between males and females. model-projected reductions in hpv incidence under different vaccination scenarios were applied to a stochastic model of cervical carcinogenesis to project lifetime costs and ben ... | 2007 | 17923869 |
| vaccination against human papillomavirus: a baseline survey of canadian clinicians' knowledge, attitudes and beliefs. | we assessed canadian obstetrician/gynaecologists', family physicians' and paediatricians' knowledge, attitudes, and beliefs about hpv infection and prevention, as well as factors associated with willingness to prescribe hpv vaccines. a self-administered, anonymous questionnaire was mailed to 2500 physicians. the participation rate was 51%. overall, 95% of respondents indicated that the vaccine should be given to girls before the onset of sexual activity; 80% of respondents felt that the best age ... | 2007 | 17923173 |
| human papillomavirus dna testing for the detection of cervical intraepithelial neoplasia grade 3 and cancer: 5-year follow-up of a randomised controlled implementation trial. | tests for the dna of high-risk types of human papillomavirus (hpv) have a higher sensitivity for cervical intraepithelial neoplasia grade 3 or worse (cin3+) than does cytological testing, but the necessity of such testing in cervical screening has been debated. our aim was to determine whether the effectiveness of cervical screening improves when hpv dna testing is implemented. | 2007 | 17919718 |
| p53 codon 72 polymorphism and the risk of esophageal squamous cell carcinoma. | the polymorphisms of the tumor suppressor gene p53 have been extensively investigated in numerous malignant tumors, particularly carcinomas associated with human papillomavirus (hpv) infection. however, the results remain controversial. to address a potential correlation between the p53 genotypes and the risk of esophageal squamous cell carcinoma (escc), we investigated the p53 codon 72 polymorphism in 435 patients with escc and 550 cancer-free subjects from the same geographical region. p53 arg ... | 2008 | 17918207 |
| cost-effectiveness of adding human papilloma virus testing to a managed care cervical cancer screening program. | the purpose of this study was to demonstrate a methodology for auditing the impact of hcii testing on the direct cost of cervical cancer cytological screening, where the test is collected in all women screened and processed routinely in women age 30 years and older. | 2007 | 17917570 |
| 2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ. | to provide updated consensus guidelines for the management of women with cervical intraepithelial neoplasia (cin) or adenocarcinoma in situ (ais). | 2007 | 17917567 |
| herd immunity. | 2007 | 17915372 | |
| determination of human papillomavirus type 16 genotype and construction of cloning vector ptz57r encoding hpv16 e7 gene. | to isolate and construct a cloning vector containing the human papillomavirus (hpv)16-e7 gene as a target for application as a dna vaccine. | 2007 | 17914510 |
| [mucosotropic papillomavirus genotypes in the italian population]. | 2007 | 17912182 | |
| clinical aspects of epidermodysplasia verruciformis and review of the literature. | epidermodysplasia verruciformis (ev), is an unusual genodermatosis characterized by persistent human papilloma virus infection with an autosomal recessive inheritance pattern. clinically, it is characterized by flat wart-like lesions, scaly hypo- and hyperpigmented macules and/or patches, which resemble pityriasis versicolor, and development of early beginning nonmelanoma cutaneous carcinomas. | 2007 | 17910717 |
| p16(ink4a) immunocytochemistry in liquid-based cytology samples in equivocal pap smears: added value in management of women with equivocal pap smear. | to test whether p1l6(ink4a) immunocytochemistry (icc) in liquid-based cytology (lbc) is useful with colposcopy in abnormal pap smears. | 2007 | 17910346 |
| bug breakfast in the bulletin: human papilloma virus. | the bug breakfast topic for october was human papilloma virus (hpv). the presenters covered the epidemiology of hpv, the newly introduced hpv vaccine and social and psychological issues relating to hpv vaccination. | 2007 | 17907356 |
| interobserver agreement in the evaluation of digitized cervical images. | to estimate the agreement among multiple expert colposcopists evaluating high-resolution digitized cervigrams taken from patients with a variety of human papillomavirus (hpv) infection states and previous cervigram interpretations. | 2007 | 17906017 |
| a novel splice donor site at nt 1534 is required for long-term maintenance of hpv31 genomes. | human papillomaviruses (hpv) are small double-stranded dna viruses that replicate as low copy number nuclear plasmids during the persistent phase. hpv only possess nine open reading frames but extend their coding capabilities by alternative rna splicing. we have identified in cell lines with replicating hpv31 genomes viral transcripts that connect the novel splice donor (sd) sites at nt 1426 and 1534 within the e1 replication gene to known splice acceptors at nt 3295 or 3332 within the e2/e4 reg ... | 2008 | 17904182 |
| the human papillomavirus type 16 e7 oncoprotein activates the fanconi anemia (fa) pathway and causes accelerated chromosomal instability in fa cells. | fanconi anemia (fa) patients have an increased risk for squamous cell carcinomas (sccs) at sites of predilection for infection with high-risk human papillomavirus (hpv) types, including the oral cavity and the anogenital tract. we show here that activation of the fa pathway is a frequent event in cervical sccs. we found that fa pathway activation is triggered mainly by the hpv type 16 (hpv-16) e7 oncoprotein and is associated with an enhanced formation of large fancd2 foci and recruitment of fan ... | 2007 | 17898070 |
| human papillomavirus (hpv) genotype distribution in invasive cervical cancers in france: edith study. | invasive cervical cancer (icc) remains a significant cause of morbidity and mortality in france. since human papillomavirus (hpv) is the necessary cause of icc, the aim of this study was to assess the type-specific prevalence of hpv in icc in france in order to locally evaluate the potential benefit of an hpv 16/18 l1 virus-like particles (vlp) vaccination. a total of 516 histological specimens collected in 15 centers were analyzed. among them, 86% had a diagnosis of squamous cell carcinoma (scc ... | 2008 | 17893882 |
| rising incidence of oropharyngeal cancer and the role of oncogenic human papilloma virus. | to document the increasing incidence of oropharyngeal (op) cancer and to provide evidence that this increase is caused by oncogenic human papilloma virus (hpv). | 2007 | 17891052 |
| effects of quadrivalent human papillomavirus vaccination. | 2007 | 17889236 | |
| abnormal anal cytology in high-risk human papilloma virus infection in hiv-infected australians. | to assess the prevalence of abnormal anal cytology and high-risk human papilloma virus (hpv)-type infection in hiv-infected people with a cd4 cell count >300 cells/microl. | 2008 | 17881414 |
| [study on the genotyping of human papillomavirus using a new dna liquid chip in women of high-risk group of shandong province]. | to evaluate the diagnostic applicability of human papillomavirus (hpv) liquid chip assay which is based on luminex xmap system, and perform a hpv epidemiologic study with the liquid chip in women of shandong province. | 2007 | 17877181 |
| update on vaccination against human papillomavirus (hpv). | hpv vaccine offers a new approach to preventing hpv and associated conditions. the vaccine has mainly been studied in young women, and clinical trials have supported its efficacy in preventing genital warts and cervical precancers caused by targeted hpv types. while health care experts and others endorse the use of the vaccine, they disagree on making it mandatory. for now, lawmakers would like further discussion and debate before pushing legislation to make the vaccine a legal requirement. | 2007 | 17877102 |
| human papillomavirus vaccine. | 2007 | 17874469 | |
| comparison of the amplicor human papillomavirus test and the hybrid capture 2 assay for detection of high-risk human papillomavirus in women with abnormal pap smear. | infection with human papillomavirus (hpv) is a necessary step in the progression to cervical cancer. many methods for hpv testing are currently available, mostly developed to detect pools of hpv types. hybrid capture 2 (hc2) is one of the most widely used. a new pcr-based assay, the roche amplicor hpv test, has been recently developed. both assays recognize a group of 13 hr hpv types contemporaneously. this study evaluated the performance of both methods for detecting high-grade cervical lesions ... | 2008 | 17854914 |
| human papillomavirus dna detection in thinprep pap test vials is independent of cytologic sampling of the transformation zone. | sampling of the transformation zone (tz) and endocervical cells (ec) has been widely regarded as a quality indicator in cervical screening programs; however, the significance of a tz/ec sample (tz/ecs) in promoting disease detection remains a matter of controversy. because little data are available on the relationship between tz/ec sampling and hpv dna test results, we examined whether or not there is a measurable association between high-risk human papillomavirus (hrhpv) dna test results and tz ... | 2007 | 17854873 |
| an oncolytic mutant of herpes simplex virus type-1 in which replication is governed by a promoter/enhancer of human papillomavirus type-16. | although herpes simplex virus type-1 (hsv-1) can be used as an oncolytic virus it has the undesirable side effect of neurotoxicity. to create a virus with improved specificity for oral cancer we used a fragment of human papillomavirus type-16, which is frequently found in oral and cervical cancers, but not elsewhere. the upstream regulatory region, urr16, was shown to have a high level of transcriptional activity in three of four oral cancer cell lines but low activity in three cell lines derive ... | 2007 | 17853922 |
| strategic plans to promote head and neck cancer translational research within the radiation therapy oncology group: a report from the translational research program. | head and neck cancer is the fifth most common cancer in the united states, with an overall survival rate of approximately 40-50%. in an effort to improve patient outcomes, research efforts designed to maximize benefit and reduce toxicities of therapy are in progress. basic research in cancer biology has accelerated this endeavor and provided preclinical data and technology to support clinically relevant advances in early detection, prognostic and predictive biomarkers. recent completion of the h ... | 2007 | 17848300 |
| relationship between the expression of telomerase and human papillomavirus infection in invasive uterine cervical carcinoma. | telomerase activity was examined in invasive cervical carcinoma to assess whether it is activated during cervical malignant transformation and to look for its possible association with human papillomavirus (hpv) infection. histologically confirmed invasive cervical carcinomas and benign cervices were assayed for telomerase activity by using a modified telomere repeat amplification protocol (trap). the same cases were subjected to polymerase chain reaction (pcr) detection of hpv by using consensu ... | 2007 | 17828509 |
| human papillomavirus type 16 e7 oncoprotein inhibits apoptosis mediated by nuclear insulin-like growth factor-binding protein-3 by enhancing its ubiquitin/proteasome-dependent degradation. | the e7 protein encoded by the oncogenic human papillomavirus type 16 has been shown to bind and inactivate insulin-like growth factor-binding protein-3 (igfbp-3), the pro-apoptotic product of a tumour suppressor gene; however, the molecular mechanism underlying e7-induced inactivation of igfbp-3 remained uncertain. in this study, we map the igfbp-3-binding domain for e7 to the nuclear localization signal in the conserved c-terminal domain of igfbp-3. moreover, we demonstrate that both proteins i ... | 2007 | 17827406 |
| combination of intratumoral injections of vaccinia virus mva expressing gm-csf and immunization with dna vaccine prolongs the survival of mice bearing hpv16 induced tumors with downregulated expression of mhc class i molecules. | downregulation of mhc class i molecules is believed to be often the cause of tumor immune escape and at the same time it is the major obstacle to t-cell based immunotherapy of tumors. in our experimental model, the c57bl/6 mice bearing tumors induced by tc-1/a9 cells characterized by expression of hpv16 oncogenes and downregulation of h-2b molecules were immunized with highly immunogenic e7ggg.gus dna vaccine expressing the fused gene of modified hpv16 e7 (e7ggg) with e.coli beta-glucuronidase ( ... | 2007 | 17822323 |
| racial and ethnic disparities in cervical cancer incidence rates in the united states, 1992-2003. | differences in cervical cancer incidence rates by race/ethnicity persist in the united states. we examined these differences by histologic type and by various patient and socioeconomic characteristics. | 2007 | 17805982 |
| human papillomavirus e6 regulates the cytoskeleton dynamics of keratinocytes through targeted degradation of p53. | the attachment and spreading of keratinocyte cells result from interactions between integrins and immobilized extracellular matrix molecules. human papillomavirus type 16 (hpv-16) e6 augmented the kinetics of cell spreading, while e6 genes from hpv-11 or bovine papillomavirus type 1 did not. the ability of e6 to interact with the e6ap ubiquitin ligase and target p53 degradation was required to augment cell-spreading kinetics; dominant negative p53 alleles also enhanced the kinetics of cell sprea ... | 2007 | 17804489 |
| [antisense targeting to human papillomavirus 18 e6/e7 affects the proliferation and apoptosis of human cervical carcinoma: an in vitro experiment with hela cells]. | to investigate the effect of eukaryotic fluorescent expression vector carrying antisense human papillomavirus (hpv) 18 e6/e7 on the growth and proliferation of human cervical carcinoma. | 2007 | 17803852 |
| human papillomavirus: e6 and e7 oncogenes. | the recognition of a causal relationship between human papillomaviruses and cancer almost 30 years ago led to a rapid expansion of knowledge in the field, resulting in the description of the main mediators of hpv-induced carcinogenesis, the viral proteins e6 and e7. these oncoproteins show a remarkable pleiotropism in binding host-cell proteins, with the tumour suppressor genes p53 and prb as their major targets. these interactions induce proliferation, immortalization and malignant transformati ... | 2007 | 17768080 |
| [analysis of demethylation-related hpv16 reactivation by dhplc-primer extension assay]. | to establish a sensitive assay to detect methylation status of the critical 7862nt cpg site related to transcription of hpv16 e6 and e7 genes. | 2007 | 17767865 |
| hpv triage testing or repeat pap smear for the management of atypical squamous cells (ascus) on pap smear: is there evidence of process utility? | a two-stage standard gamble was used to evaluate women's preferences for alternative managements of atypical squamous cells of undermined significance (ascus) on pap smear (repeat pap smear compared with immediate hpv test), and to test for the evidence of process utility. women's utilities for the health state scenarios were clustered towards the upper end of the 0-1 scale with considerable variability in women's preferences. there was evidence of process utility, with immediate human papilloma ... | 2008 | 17764095 |
| expression of p53 and its homolog, p73, in hpv dna positive oesophageal squamous cell carcinomas. | several studies have detected human papilloma virus (hpv) dna in squamous cell carcinoma of the oesophagus (oscc). in this study, we analysed oscc specimens from 114 patients for the presence of hpv dna, and p53 and p73 expression. hpv dna was detected in 44.7% of cases, with the low risk hpv11 occurring most frequently. p53 and p73 expression was detected in 70% and 61.4% of cases, respectively. there was no correlation between expression of p53, p73 or hpv infection and tumour grade, or betwee ... | 2007 | 17761206 |
| national vaccination coverage among adolescents aged 13-17 years--united states, 2006. | before 2005, vaccines were administered during adolescence to "catch up" children with vaccinations not received at a younger age, with the exception of the tetanus and diphtheria (td) booster. however, since 2005, three new vaccines specifically for older children have been licensed and recommended in the united states: meningococcal conjugate vaccine (mcv4) for those aged 11-12 years and 15 years; tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (tdap) vaccine for those aged ... | 2007 | 17728694 |
| re: "multiparameter calibration of a natural history model of cervical cancer". | 2007 | 17728268 | |
| a doctor talks about hpv vaccination. | 2007 | 17726760 | |
| induction of mhc class i molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours. | epigenetic events play an important role in tumour progression and also contribute to escape of the tumour from immune surveillance. in this study, we investigated the up-regulation of major histocompatibility complex (mhc) class i surface expression on tumour cells by epigenetic mechanisms using a murine tumour cell line expressing human e6 and e7 human papilloma virus 16 (hpv16) oncogenes and deficient in mhc class i expression, as a result of impaired antigen-presenting machinery (apm). treat ... | 2008 | 17725605 |
| circulating human papillomavirus type 16 specific t-cells are associated with hla class i expression on tumor cells, but not related to the amount of viral oncogene transcripts. | human papillomavirus (hpv) is a necessary factor in the pathogenesis of cervical cancer. circulating hpv-specific t-cells responding to the e6 and e7 hpv proteins can be detected only in half of cervical cancer patients. potential explanations for the absence of this response are lack of sufficient amounts of antigen to activate the immune response or local immune escape mechanisms. we studied the relationship between hpv 16 e6/e7 oncogene mrna expression, human leukocyte antigen (hla) expressio ... | 2007 | 17724722 |
| evaluation of quantity and staining pattern of human papillomavirus (hpv)-infected epithelial cells in thin-layer cervical specimens using optimized hpv-card assay. | testing for human papillomavirus (hpv) is used in the triage of women with a cervical cytology of atypical squamous cells of undetermined significance (ascus). a fluorescent in situ hybridization assay was developed for the detection of hpv using the catalyzed receptor deposition technique (hpv-card). in this study, the utility of this assay was tested for the detection of hpv in liquid-based cervical cytology specimens. | 2007 | 17724679 |
| human papillomavirus vaccines launch a new era in cervical cancer prevention. | 2007 | 17724324 | |
| human papillomavirus vaccine: waiting for a miracle. | 2007 | 17724313 | |
| [malignancy arising in seborrheic keratosis: two cases report]. | seborrheic keratosis are one of the most common benign epidermal tumors encountered in clinical practice. malignant transformation is exceptional. it may occur by the involvement of human papilloma virus. we report two cases of seborrheic keratosis in respectively 58 and 60-years-old women, which, on biopsy, revealed the presence of bowen's disease for the former and squamous cell carcinoma for the later. | 2003 | 17722804 |
| vaccination trial with hpv16 l1e7 chimeric virus-like particles in women suffering from high grade cervical intraepithelial neoplasia (cin 2/3). | persistent infection with human papillomaviruses (hpv) is a prerequisite for the development of cervical cancer. vaccination with virus-like particles (vlp) has demonstrated efficacy in prophylaxis but lacks therapeutic potential. hpv16 l1e7 chimeric virus-like particles (cvlp) consist of a carboxy-terminally truncated hpv16l1 protein fused to the amino-terminal part of the hpv16 e7 protein and self-assemble by recombinant expression of the fusion protein. the cvlp are able to induce l1- and e7- ... | 2007 | 17721997 |
| activation of akt and nuclear accumulation of wild type tp53 and mdm2 in anal squamous cell carcinoma. | human papilloma virus (hpv) infection is considered as an important aetiological factor for anal squamous cell carcinoma (ascc) but is not sufficient for tumour progression. this carcinoma is poorly understood at the molecular level. using the largest cohort of cases to date we investigated the molecular mechanisms underlying ascc development, in particular the roles of tp53, mdm2 and akt. viral infection in our cohort occurred at high frequency (73%, 94/128) with hpv16 accounting for the majori ... | 2007 | 17721920 |
| association of cutaneous anergy with human papillomavirus and cervical neoplasia in hiv-seropositive and seronegative women. | cutaneous anergy testing evaluates delayed type hypersensitivity responses and is, in essence, an in-vivo measure of cell-mediated immune function at an epithelial surface. this study assessed the relationship of anergy test results with cervical infection by human papillomavirus (hpv) and cervical neoplasia in hiv-seropositive and seronegative women. | 2007 | 17721101 |
| human papillomavirus infection in hiv-infected persons. | rates of cervical and anal human papillomavirus (hpv) infection and abnormal cytology are high in hiv-infected women, as are rates of anal hpv infection and abnormal cytology in hiv-infected men who have sex with men (msm). available evidence indicates that the incidence of anal cancer in hiv-infected msm has increased in association with prolonged life expectancy achieved with antiretroviral therapy. routine screening for cervical neoplasia is recommended for hiv-infected women. routine screeni ... | 2007 | 17720998 |
| the n-terminal module of hpv16 e7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoprotein. | the hpv16 e7 oncoprotein is an extended dimer, with a stable and cooperative fold, but that displays properties of "natively unfolded" proteins. two regions of conserved sequence are found in e7 proteins, where the n-terminus (1-40) includes the retinoblastoma tumor suppressor binding and casein kinase ii phosphorylation sites. a fragment containing the highly acidic n-terminal half shows an apparently disordered conformation by far-uv-circular dichroism (cd) at neutral ph, and its hydrodynamic ... | 2007 | 17715947 |
| age-specific prevalence of high-risk human papillomavirus infection in a hungarian female population with positive cytology. | patients with positive screening results and persistence of high-risk human papillomavirus (hpv) infection represent the population at the highest risk for developing cervical cancer. to describe the epidemiology in this high-risk population, data were collected and analysed at the referral centre for patients with positive cytology. | 2008 | 17714853 |
| high-risk cervical epithelial neoplasia grade 1 treated by loop electrosurgical excision: follow-up and value of hpv testing. | this study was undertaken to evaluate the value of high-risk human papillomavirus (hpv) testing in the follow-up of cervical intraepithelial neoplasia grade 1/low-grade squamous intraepithelial lesion treated by loop electrosurgical excision procedure because of the risk criteria established by the american society for colposcopy and cervical pathology (ie, unsatisfactory colposcopy or positive endocervical curettage, persistence of cervical intraepithelial neoplasia grade 1/low-grade squamous i ... | 2007 | 17714678 |
| age at first intercourse and hpv immunization. | the licence of the first human papillomavirus vaccine (hpv) has important implications for the most appropriate age for a mandatory immunization. in this paper data taken from a recent study show that more than 10% of the italian women report having already had a sexual intercourse by the age of 15. there is thus sufficient evidence to recommend administration of the hpv vaccine to all girls by the age of 12. | 2007 | 17713135 |
| recurrence in patients with oral and oropharyngeal squamous cell carcinoma: human papillomavirus and other risk factors. | the results confirm that tumour stage influences the risk of recurrence/second primary tumour (spt). high-risk human papillomavirus (hpv)-infected patients have a significantly higher risk of recurrence/spt compared with high-risk hpv-negative patients. high alcohol consumption was associated with a higher risk of recurrence/spt. in this study, the competing risk of death in intercurrent disease (dicd) was given special consideration. | 2007 | 17712679 |
| urine versus brushed samples in human papillomavirus screening: study in both genders. | to investigate whether urine is a good medium for screening and whether there is a correlation between the amount of extracted dna and human papillomavirus (hpv)-positivity. | 2007 | 17712490 |
| the human papillomavirus vaccine and its relevance in israel. | 2007 | 17710788 | |
| b subunit of shiga toxin-based vaccines synergize with alpha-galactosylceramide to break tolerance against self antigen and elicit antiviral immunity. | the nontoxic b subunit of shiga toxin (stxb) targets in vivo ag to dendritic cells that preferentially express the glycolipid gb(3) receptor. after administration of stxb chemically coupled to ova (stxb-ova) or e7, a polypeptide derived from hpv, in mice, we showed that the addition of alpha-galactosylceramide (alpha-galcer) resulted in a dramatic improvement of the stxb ag delivery system, as reflected by the more powerful and longer lasting cd8(+) t cell response observed even at very low dose ... | 2007 | 17709554 |
| viral load of episomal and integrated forms of human papillomavirus type 33 in high-grade squamous intraepithelial lesions of the uterine cervix. | the association between total and integrated hpv-33 dna loads and high-grade squamous intraepithelial lesions (hsil) of the uterine cervix was investigated. of 5,347 women recruited in 4 studies, 89 (64 without sil, 7 low-grade sil (lsil), 15 hsil, 3 unknown grade) were infected by hpv-33. hpv-33 e6, hpv-33 e2 and beta-globin dna were measured with real-time pcr that allowed to assess total (e6), episomal (e2) and integrated (e6-e2) hpv-33 viral loads. hpv-33 e6/e2 ratios >/=>/=2.0 suggesting th ... | 2007 | 17708553 |
| do g protein-coupled receptors expressed in human lingual epithelium interact with hpv11? | human papillomaviruses infect epithelia but little is known about the nature of cell surface receptors interacting with the viral particles. it has been proposed that glycosaminoglycans and integrins may be involved in the attachment process. in the present study, the putative interactions of virus-like particles of human papillomavirus type 11 (hpv11), which present a tropism for nasopharyngeal epithelia, with olfactory and taste receptors expressed in the human lingual epithelium were studied. ... | 2007 | 17705193 |
| role of human papillomavirus genotype in prognosis of early-stage cervical cancer undergoing primary surgery. | our aim was to evaluate the prognostic significance of human papillomavirus (hpv) genotype in early-stage cervical carcinoma primarily treated with surgery in a large tertiary referral medical center. | 2007 | 17704412 |
| the impact of hiv status and type on the clearance of human papillomavirus infection among senegalese women. | persistent infection with human papillomavirus (hpv) is associated with the development and progression of hpv-related disease, including cervical intraepithelial neoplasia (cin) and invasive cervical cancer. | 2007 | 17703420 |
| profile of viral load, integration, and e2 gene disruption of hpv58 in normal cervix and cervical neoplasia. | the clinical utility of viral-load and integration status of human papillomavirus (hpv) infection remains uncertain. we examined 75 women infected with hpv58, a worldwide rare type found to be prevalent in cervical cancers in eastern asia. viral load was significantly higher for cervical intraepithelial neoplasia (cin) 1/2, but those for a normal control group and for cin 3 or cancer overlapped substantially. a pure integrated genome was found for all lesion grades, giving a poor positive predic ... | 2007 | 17703417 |
| detection of human papillomavirus genotypes 16/18/45 by hybrid capture hybridisation genotyping probe in clinical specimens: the first report. | 2007 | 17702646 | |
| effect of human papillomavirus 16/18 l1 viruslike particle vaccine among young women with preexisting infection: a randomized trial. | viruslike particle human papillomavirus (hpv) vaccines were designed to prevent hpv infection and development of cervical precancers and cancer. women with oncogenic hpv infections might consider vaccination as therapy. | 2007 | 17699008 |
| therapeutic value of trichloroacetic acid in the treatment of isolated genital warts on the external female genitalia. | to evaluate the value of 85% trichloroacetic acid (tca) in the treatment of human papillomavirus (hpv)-associated genital warts of the external genitalia and to detect the recurrence rate and side effects of this therapeutic regimen. | 2007 | 17694970 |
| multiple copies of a tumor epitope in a recombinant hepatitis b surface antigen (hbsag) vaccine enhance ctl responses, but not tumor protection. | we propose the replacement of endogenous epitopes with foreign epitopes to exploit the highly immunogenic hepatitis b surface antigen (hbsag) as a vaccine vector to elicit disease-protective cytotoxic t-lymphocyte (ctl) responses. locations were defined within the hbsag gene where replacements of dna encoding hbsag epitopes may be made to generate functional recombinant (r) hbsag dna vaccines. we demonstrate that rhbsag dna vaccines encoding multiple copies of a model tumor epitope from human pa ... | 2007 | 17689584 |
| inhibition of transfer to secondary receptors by heparan sulfate-binding drug or antibody induces noninfectious uptake of human papillomavirus. | infection with various human papillomaviruses (hpvs) induces cervical cancers. cell surface heparan sulfates (hs) have been shown to serve as primary attachment receptors, and molecules with structural similarity to cell surface hs, like heparin, function as competitive inhibitors of hpv infection. here we demonstrate that the n,n'-bisheteryl derivative of dispirotripiperazine, dstp27, efficiently blocks papillomavirus infection by binding to hs moieties, with 50% inhibitory doses of up to 0.4 m ... | 2007 | 17686860 |
| retinoic acid receptor beta silences human papillomavirus-18 oncogene expression by induction of de novo methylation and heterochromatinization of the viral control region. | retinoic acid receptor beta2 (rar beta2) is often down-regulated during the multistep process to cervical cancer. in that way, its inhibitory function on the transcription factor ap-1, indispensable to maintain human papillomavirus (hpv) gene expression is relieved. using hpv-18 positive hela cells as a model system, we show that ectopic expression of rar beta2 is able to down-regulate hpv-18 transcription by selectively abrogating the binding of ap-1 to the viral regulatory region in a ligand-i ... | 2007 | 17686773 |
| [transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53]. | inactivation of tumor suppressor p53 accompanies the majority of malignant diseases in humans. restoration of p53 functions in tumor results in death of cancer cells, which can be used in cancer therapy. in cervical cancer a product of e6 gene of the human papilloma virus promotes accelerated degradation of p53 in proteasome system. therefore, one of the approaches to reactivation of p53 in cervical carcinoma cells could be the use of small molecules that inhibit functions of viral proteins. by ... | 2007 | 17685229 |
| colposcopy is not necessary to assess the risk to the cervix in hiv-positive women: an international cohort study of cervical pathology in hiv-1 positive women. | the objectives of this prospective multicentre international cohort study are to describe the characteristics of a cohort of hiv-1 positive women and determine the best management system by comparing cervical pathology according to results of cytology, colposcopy and human papillomavirus (hpv) testing at baseline and throughout follow-up. a. cohorts of known hiv-positive women were recruited from 6 hospital-based european centres and a community-based south african centre. following registration ... | 2007 | 17683070 |
| stat1 gene expression in cervical carcinomas. | expression of the stat1 gene belonging to the group of interferon-regulated genes was analyzed in cervical tumors and cell lines harboring the genome of human papilloma viruses (hpv) of so-called high risk group. expression of this gene in invasive carcinomas was maintained on a definite level that was not significantly distinct from that in adjacent normal (control) tissue. tumors from different patients differ from each other by expression level of the stat1 gene. these variations can be attri ... | 2007 | 17680769 |
| the human papillomavirus type 18 e6 oncoprotein induces vascular endothelial growth factor 121 (vegf121) transcription from the promoter through a p53-independent mechanism. | altered angiogenic response is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. vascular endothelial growth factor (vegf) is one of the most potent inducers of angiogenesis and is up-regulated in carcinoma of the cervix. infection by high-risk human papillomavirus and persistent expression of viral oncogene e6 are etiologically linked to the development of cervical cancer. e6 is able to immortalize cells and induce malignant transformation by inac ... | 2007 | 17678892 |
| high-risk human papillomavirus is present in cytologically false-negative smears: an analysis of "normal" smears preceding cin2/3. | cervical screening, currently performed by cervical cytology, depends on the timely detection of malignant lesions for its success. the presence of high-risk human papillomavirus (hrhpv) is associated with an increased risk of subsequent high-grade cervical intra-epithelial neoplasia (cin2/3) and cervical cancer. the aim of this study was to determine the extent to which hrhpv is present in cervical smears with a high a priori chance of being false negative (ie, in normal smears preceding cin2/3 ... | 2008 | 17675539 |
| human papillomavirus genotyping after denaturation of specimens for hybrid capture 2 testing: feasibility study for the hpv persistence and progression cohort. | human papillomavirus (hpv) genotyping could be clinically useful, depending on the results of large, prospective studies like the hpv persistence and progression (pap) cohort. the cohort is based on genotyping and follow-up of hybrid capture-positive women at kaiser permanente, northern california. hpv dna testing by hybrid capture 2 requires denaturation with alkali, possibly damaging the dna for optimal pcr-based genotyping. a feasibility study was conducted on paired aliquots of anonymized sp ... | 2007 | 17673302 |
| the correlation between fhit, p53 and mmr genes in human papillomavirus-associated cervical carcinoma. | high risk human papillomavirus (hr-hpv) types have been closely associated with cervical carcinoma. however, other genetic events are likely to be required, in addition to hpv infection, for the development of cervical cancer. we investigated 20 human cervical carcinomas and 15 normal cervical tissues for the correlation between aberrant expression of the fhit, p53 and mmr genes and their prognostic impact. | 2006 | 17671528 |
| prophylactic human papillomavirus vaccines: potential for sea change. | persistent human papillomavirus (hpv) infection is the central cause in the development of anogenital warts, precancers and cancers of uterine cervix, and a major factor in the genesis of other malignancies of the lower anogenital and upper aerodigestive tracts. the burden of disease carries very high medical, financial and psychosocial costs. the role of prophylactic hpv vaccines in reducing the burden of disease is discussed in light of the results of multiple randomized, controlled trials con ... | 2007 | 17669006 |
| [identification of human papilloma viruses (hpv) in inflammatory states and ear neoplasms]. | human papilloma virus has a strong relation to oropharyngeal mucosa and is considered to be responsible for a wide range of upper respiratory tract pathologies, like laryngeal papilloma. there's a hypothesis, that it plays a significant role in middle ear chronic inflammations and neoplasm's. material and methodic. the examination was carried on a group of 53 patients, 39 of which was suffering from granulation tissue chronic otitis media, 7-cholesteatomatous otitis media, 6--middle ear malignan ... | 2007 | 17668798 |
| recent advances in the search for antiviral agents against human papillomaviruses. | infection by human papillomavirus (hpv) is extremely common and associated with the development of benign warts or malignant lesions of the skin and mucosa. infection by a high-risk (oncogenic) anogenital hpv type, most often through sexual contacts, is the starting point of virtually all cases of cervical cancers and the majority of anal cancers. the same viral types are also increasingly being linked with a subset of head-and-neck and non-melanoma skin cancers. although prophylactic vaccines a ... | 2007 | 17668552 |
| politics and power plays behind the hpv vaccine. an effective vaccine is mired in controversy by mandates. | 2007 | 17667381 | |
| viruses and human breast cancer. | there are well-established risk factors for breast cancer, most of which relate to estrogens and growth hormones in females. these include early-age menarche, late-age menopause, postmenopausal obesity and use of hormone therapy. however, these factors do not account for the sixfold difference in breast cancer incidence and mortality between countries and the fact that these differences dramatically lessen after migration; nor do they account for male breast cancer. accordingly, hormone-responsi ... | 2006 | 17661684 |
| inappropriate gold standard bias in cervical cancer screening studies. | as acetic acid-aided visual inspection (via) and colposcopic-directed biopsy miss small >/=cervical intraepithelial neoplasia (cin) 2, inflation of sensitivity of via may occur when colposcopic-directed biopsy is the gold standard for >/=cin 2. to determine whether such inflation occurs, we reviewed 375 women with >/=cin 2 from the shanxi province cervical cancer screening study ii. these women had positive self or physician-collected tests for high-risk human papillomavirus or abnormal cervical ... | 2007 | 17657715 |
| prevalence of human papillomavirus in squamous cell carcinoma of the tongue. | oncogenic human papillomaviruses (hpvs) are important agents in the genesis of gynecological cancer, and have also been implied in the genesis of oral cancer. with the purpose of evaluating the relationship between hpv and squamous cell carcinoma (scc) of the tongue, a case-control study was performed. fifty white male patients who were smokers and had the histological diagnosis of scc of the tongue were selected. the control group was composed of 10 matched patients with no clinical evidence of ... | 2007 | 17656122 |
| coinfection of chlamydia trachomatis, ureaplasma urealyticum and human papillomavirus among patients attending std clinics in estonia. | women visiting estonian std clinics were subjected to pcr assay for human papillomavirus (hpv), chlamydia trachomatis and ureaplasma urealyticum biovar 2. the overall prevalence of coinfection was 8%. the chlamydial infection was found to be associated with hpv, especially with high-risk hpv (or=2.5, p<0.005) and most significantly in women over 41 y of age. c. trachomatis infection also occurred more frequently in u. urealyticum-infected than in u. urealyticum-free patients (or=2.6, p=0.02). u. ... | 2007 | 17654349 |
| [anorectal lesions in hiv-positive patients using highly active antiretroviral therapy]. | anorectal lesions are common in patients with human immunodeficiency virus (hiv). highly active anti-retroviral therapy (haart) has little influence on the progression of anal neoplasms. the prevalence of anorectal lesions in 88 hiv-positive patients attended at the infectious diseases service of the university hospital of brasília who were using haart was studied. sociodemographic data were collected using a pre-prepared questionnaire and then the patients underwent proctological examination. a ... | 2007 | 17653462 |
| basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of e6 and e7 proteins. | human papillomaviruses (hpv) are believed to be the primary causal agents for development of pre-neoplastic and malignant lesions of the uterine cervix, and high-risk types such as type 16 and 18 are associated with more than 90% of all cervical carcinomas. the e6 and e7 genes of hpv are thought to play causative roles, since e6 promotes the degradation of p53 through its interaction with e6ap, an e3 ubiquitin ligase, whereas e7 binds to the retinoblastoma protein (prb) and disrupts its complex ... | 2007 | 17645777 |
| high expression of human telomerase reverse transcriptase in high-grade intraepithelial neoplasia and carcinoma of uterine cervix and its correlation with human papillomavirus infection. | most of cervical intraepithelial neoplasia 1 (cin 1) will regress and 12% to 40% of high-grade cin may progress to squamous cell carcinoma (scc) of the uterine cervix. however, the differentiation of cin 1 and high-grade cin is sometimes controversial among pathologists. human telomerase reverse transcriptase (htert) is therefore applied to detect the differences among normal, cin 1, high-grade cin, and scc tissues of uterine cervix. one hundred six cervical specimens were collected for immunohi ... | 2007 | 17644806 |
| malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus. | the patient was a 57-year-old white woman who presented with a 3.0 x 2.0-cm partially ulcerated vaginal polyp. histology revealed a malignant mixed mullerian tumor composed of invasive squamous cell carcinoma with deeper areas of undifferentiated pleomorphic sarcoma. invasive carcinoma had overlying high-grade vaginal intraepithelial neoplasia (vain iii), which contained koilocytic atypia. in situ hybridization detected high-risk human papillomavirus dna in both the carcinoma and the sarcoma com ... | 2007 | 17640554 |
| estimation of prognoses for cervical intraepithelial neoplasia 2 by p16ink4a immunoexpression and high-risk hpv in situ hybridization signal types. | the present study used immunohistochemical staining and in situ hybridization (ish) to examine whether progression of cervical intraepithelial neoplasia, grade 2 (cin 2) can be predicted by p16ink4a immunoexpression and high-risk human papilloma virus (hpv) ish signal types. we studied 52 cases histologically diagnosed with cin 2: dysplasia regressed in 28 cases; 13 cases progressed to cin 3; and cin 2 persisted in 11 cases. expression of p16ink4a and high-risk hpv signal both related to grade o ... | 2007 | 17638654 |
| cervical cancer screening of women living with hiv infection: a must in the era of antiretroviral therapy. | women living with human immunodeficiency virus (hiv) infection have a much higher risk of human papillomavirus infection and cervical cancer than do hiv-uninfected women. before the introduction of antiretroviral therapy, the lack of cervical cancer screening among hiv-infected women probably had little influence on their life expectancies because of the high competing mortality associated with other causes, but the situation is changing rapidly everywhere. in sub-saharan africa, for instance, a ... | 2007 | 17638204 |
| getting the message out: rna interference of human papillomavirus. | 2007 | 17636210 | |
| [progress of study on anti-human cervical papilloma virus infection with chinese and western medicine]. | human papilloma virus (hpv) infection is closely correlated with the occurrence of cervical cancer and precancerous lesion, high risk hpv can induce cervical cancer by the corresponding protein of e6 and e7 gene expression. earlier diagnosis and earlier prevention of hpv infection are the key points in blocking cervical cancer, and combined use of chinese herbal preparations with western medicine is the important way for preventing hpv infection and prohibiting cervical canceration. so, to devel ... | 2007 | 17633379 |
| a phase ii study of hsp-7 (sgn-00101) in women with high-grade cervical intraepithelial neoplasia. | approximately 2 million women worldwide are infected with high-risk human papillomaviruses (hpv), resulting in a substantial risk for the development of invasive lower genital malignancies. this study was undertaken to determine the effects of vaccination with a protein encoding a bacterial heat shock protein fused to sequences from the oncogenic e7 protein of hpv-16 in women with high-grade cervical intraepithelial neoplasia. endpoints included lesion regression, immune response, and viral clea ... | 2007 | 17631950 |
| immunizations, neonatal hyperbilirubinemia and animal-induced injuries. | to report recent research findings and new recommendations on immunizations, neonatal hyperbilirubinemia, and animal-induced injuries. | 2007 | 17630617 |
| human papilloma virus vaccine: a new frontier or political controversy? | 2007 | 17630600 | |
| oncogenic properties of hiv-tat in colorectal cancer cells. | with the advent of highly-active-anti-retroviral-therapy (haart), hiv patients can expect to live beyond 10-15 years following diagnosis. an unexpected result of increased survival is the emergence of opportunistic, oncogenic virus-associated cancers such as burkitt's lymphoma (epstein-barr virus), cervical cancer (human papilloma virus) and kaposi's sarcoma (kaposi's sarcoma-associated herpesvirus) in this immuno-compromised population. furthermore, there are reports of colorectal cancers (crc) ... | 2007 | 17627503 |
| therapeutic vaccination for hpv induced cervical cancers. | cervical cancer is the second leading cause of cancer-related deaths in women worldwide and is associated with human papillomavirus (hpv) infection, creating a unique opportunity to treat cervical cancer through anti-viral vaccination. although a prophylactic vaccine may be available within a year, millions of women, already infected, will continue to suffer from hpv-related disease, emphasizing the need to develop therapeutic vaccination strategies. a majority of clinical trials examining thera ... | 2007 | 17627067 |
| hpv infection in men. | while much is known about the natural history of cervical human papillomavirus (hpv) infection and its consequences, including cervical intraepithelial neoplasia and cervical cancer, relatively little is known about the natural history of anogenital hpv infection and diseases in men. in part this reflects difficulties in penile sampling and visual assessment of penile lesions. anal hpv infection and disease also remain poorly understood. although hpv is transmitted sexually and infects the genit ... | 2007 | 17627061 |
| progression and regression of incident cervical hpv 6, 11, 16 and 18 infections in young women. | we describe type-specific progression, regression and persistence of incident human papillomavirus (hpv)-6-11-16 and -18 infections, along with type distribution in cervical intra-epithelial neoplasia (cin) lesions. | 2007 | 17626624 |
| brd4-independent transcriptional repression function of the papillomavirus e2 proteins. | the papillomavirus e2 protein is a critical viral regulatory protein with transcription, dna replication, and genome maintenance functions. we have previously identified the cellular bromodomain protein brd4 as a major e2-interacting protein and established that it participates in tethering bovine papillomavirus type 1 e2 and viral genomes to host cell mitotic chromosomes. we have also shown that brd4 mediates e2-dependent transcriptional activation, which is strongly inhibited by the disruption ... | 2007 | 17626100 |