Publications

acute health effects from community exposure to n-propyl mercaptan from an ethoprop (mocap)-treated potato field in siskiyou county, california.		2006	1472222
tracking clinical learning experience.		2006	1472156
identification of amino acid changes affecting yeast uroporphyrinogen decarboxylase activity by sequence analysis of hem12 mutant alleles.	the molecular basis of the uroporphyrinogen decarboxylase defect in eleven yeast 'uroporphyric' mutants was investigated. uroporphyrinogen decarboxylase, an enzyme of the haem-biosynthetic pathway, catalyses the decarboxylation of uroporphyrinogen to coproporphyrinogen and is encoded by the hem12 gene in the yeast saccharomyces cerevisiae. the mutations were identified by sequencing the mutant hem12 alleles amplified in vitro from genomic dna extracted from the mutant strains. four mutations lea ...	1992	1471989
an oral b subunit: whole cell vaccine against cholera.	during the last decade there has been a rapid progress in the development of new, much improved vaccines against cholera. these vaccines, which are given orally to stimulate the gut mucosal immune system, are based on either a combination of purified cholera toxin b (binding) subunit and killed cholera vibrios of inaba and ogawa serotypes and el tor and classical biotypes (b subunit-whole cell vaccine, b-wc) or on a live attenuated mutant strain of vibrio cholerae producing the b subunit (cvd 10 ...	1992	1471411
the diagnosis and treatment of cholera.	cholera is a diarrheal disease that results from colonization of the small intestine by the vibrio cholerae organism. the disease is spread primarily by means of fecal contamination of drinking water and may begin with the sudden onset of profuse, watery diarrhea. vomiting, rapid dehydration, acidosis, muscular cramps and circulatory collapse are other prominent features of severe cholera. diagnosis is confirmed by identification of the organism in a stool specimen. treatment requires immediate ...	1992	1465231
guanine nucleotide binding proteins in the dual regulation of lacrimal function.	the purpose of this study was to identify and characterize functional g proteins that couple regulatory peptides with lacrimal secretory functions. membranes were prepared from isolated rat exorbital lacrimal gland acini, and guanosine 5'-triphosphate (gtp)-dependence of adenylyl cyclase activity, known to be coupled with regulation of secretion, was measured. the guanine nucleotide gtp produced a biphasic response in the activity of membrane-bound adenylyl cyclase during a 10 min incubation wit ...	1992	1464505
[congestive gastropathy in liver cirrhosis].		2006	1464392
intravenous nifedipine for prevention of myocardial ischaemia after coronary revascularization.	we sought to determine the pharmacokinetic and pharmacodynamic behaviour of a continuous infusion of nifedipine given for prevention of myocardial ischaemia following coronary artery bypass graft (cabg) surgery. patients scheduled for elective cabg, who had good left ventricular function, were included. only normotensive patients who did not require treatment with vasoactive drugs and were bleeding less than 100 ml.hr-1 following surgery were included. the patients were randomly distributed into ...	2006	1464126
eating behavior in continuous ambulatory peritoneal dialysis and hemodialysis patients.	three groups consisting of 12 subjects each (continuous ambulatory peritoneal dialysis [capd] patients, hemodialysis patients, and healthy controls) matched for age, sex, and body weight were invited to a test meal for the study of hunger, fullness, and food preferences. they were served an excess portion of hash served on a plate placed on a hidden scale ("viktor"), which was connected to a computer registering the eating process on-line. the patients filled in visual analogue scales (vas) conc ...	2006	1462988
aids surveillance in europe: status at 31st march 1992. european centre for the epidemiological monitoring of aids.		2006	1462717
the protective activity of tea catechins against experimental infection by vibrio cholerae o1.	tea catechins inhibited the fluid accumulation induced by cholera toxin in sealed adult mice. the catechins also reduced fluid accumulation by vibrio cholerae o1 in ligated intestinal loops of rabbits. these findings suggest that tea catechins may possess protective activity against v. cholerae o1.	1992	1461156
pathogenesis and ecology: the case of cholera.	the way in which the results of various studies of cholera have influenced the understanding of the disease are discussed. attention is given to the outcomes of medical research, targeted on problems of cholera and biological research focused on understanding vibrio cholerae. the contrast between these approaches has produced a new understanding of the ecological nature of disease. the importance of the environmental reservoir of v. cholerae as the engine for the generation of diversity is highl ...	1992	1460695
evidence for an s-layer protein pool in the peptidoglycan of bacillus stearothermophilus.	intact cells of bacillus stearothermophilus pv72 revealed, after conventional thin-sectioning procedures, the typical cell wall profile of s-layer-carrying gram-positive eubacteria consisting of a ca. 10-nm-thick peptidoglycan-containing layer and a ca. 10-nm-thick s layer. cell wall preparations obtained by breaking the cells and removing the cytoplasmic membrane by treatment with triton x-100 revealed a triple-layer structure, with an additional s layer on the inner surface of the peptidoglyca ...	1992	1459950
dermatologic lasers: three decades of progress.		2006	1459753
haemorheology and exercise: intrinsic flow properties of blood in marathon running.	haemorheological and haematological parameters were studied in venous blood samples taken from 8 endurance-trained athletes before and after a marathon run. viscometry was performed in a 20 microns glass capillary and in a couette viscometer. apparent blood viscosity was lower in the capillary than in the rotational viscometer, but significant differences between pre- and post-run samples were not observed in either system. this is presumably due to the absence of changes of haematocrit (pre-run ...	2006	1459744
aminoglycoside nephrotoxicity in clinical practice.		2006	1459713
acquired malaria--how early can it occur.		1992	1459693
peripheral exchange transfusions.		2006	1459692
should cow milk be diluted for young infants.		1992	1459690
the risk of cholecystectomy for acute cholecystitis in diabetic patients.	in order to evaluate the risk of acute cholecystitis in diabetic patients, we analyzed 2,700 consecutive cholecystectomies, 566 of which were performed in the presence of acute cholecystitis. of these patients 123 had diabetes mellitus (dm) and 433 had no diabetes (nd). the aim of this study was to establish the comparative risks in the two groups. we found that diabetics are more likely to be operated on in the acute stage of their disease (22% vs. 12%). the dm group had a higher rate of septic ...	2006	1459527
[brucella infection of the testis mimicking malignancy].	a testicular mass is a diagnostic challenge, as it may include both benign and malignant processes. due to the difficulty in diagnosis and the need to prevent complications, it is sometimes necessary to perform orchiectomy. we present an unusual case of brucellosis in which the presenting features were persistent cough for 6 months and a right testicular mass. the clinical picture and ultrasound findings suggested malignancy. orchiectomy and medical treatment resulted in rapid resolution of symp ...	1992	1459502
n-acetyl-d-glucosamine-specific lectin purified from vibrio cholerae 01.	an n-acetyl-d-glucosamine-specific cell associated hemagglutinin (ha) was isolated and purified from a strain of vibrio cholerae 01 by chitin affinity chromatography followed by separation on bio gel p-150. a single stained protein band of 47 kda in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) was observed with the purified ha. ha-antisera produced a single precipitin band against the purified ha in an immunodiffusion test without exhibiting any reactivity towards purifie ...	1992	1459412
characterization of two forms of hemagglutinin/protease produced by vibrio cholerae non-o1.	two forms (34 kda and 32 kda) of hemagglutinin/protease produced by vibrio cholerae non-o1 were characterized. the hemagglutinin/protease purified by immunoaffinity column chromatography using a monoclonal antibody was essentially a 34-kda form. by incubation of the purified 34-kda form at 37 degrees c, it was processed (autodigested) to the 32-kda form. the n-terminal 20 amino acid sequences of both the 34- and 32-kda forms were identical, suggesting that proteolytic processing at the c-termina ...	1992	1459409
[incidence, frequency and resistance characteristics of methicillin-oxacillin resistant staphylococcus aureus strains in germany].	in a multicentre study, the methicillin-resistant staphylococcus aureus (mrsa) isolates in 19 large clinics in germany were recorded, and the resistance characteristics of these strains were studied. oxacillin-mannitol-salt agar plates were distributed to all participants to ensure uniformity of screening, and each laboratory used these plates to investigate 200 consecutive staphylococcus aureus isolates for oxacillin-methicillin resistance. of the 3,794 evaluable staphylococcus aureus isolates, ...	1992	1459021
the connecticut state medical society: its antecedents and early history.		2006	1458881
problems imposed by the new technology.		2006	1458757
bacterial lipopolysaccharide mediates the loss of cd4 from the surface of purified peripheral blood monocytes.	in this study we have looked at the effect of lipopolysaccharide (lps) on the surface antigen expression of cultured monocytes. monocytes were purified from peripheral blood mononuclear cells (pbmc) and cultured in the presence or absence of lps. the cultured cells were then stained with anti-mo3, anti-il-2r and anti-cd4 moabs. we have shown that freshly isolated monocytes are il-2r- and mo3-negative and express cd4 in low density. after overnight culture, without lps, the expression of these su ...	1992	1458690
cardiac catheterization laboratory survey: 1990. society for cardiac angiography and interventions, laboratory performance standards committee.	a survey of 117 member cardiac catheterization laboratories was undertaken by the society for cardiac angiography and interventions. the survey included numbers and types of procedures, both diagnostic and interventional, in adult as well as pediatric age groups. radiation safety, various laboratory policies, frequency of short stay, and outpatient procedures were tabulated. report generation, training programs, administrative organization, and laboratory equipment were all included. the results ...	2006	1458520
caution advised when changing to new therapies.		2006	1458280
[functional capacity of patients over 65 according to the katz index. reliability of the method].	to find functional capacity of elderly patients by using the katz index, which measures the "basic activities of daily life". to examine how reliable the katz index is in the primary care field.	1978	1457702
[membrane transport of antigenic peptides].		1978	1457602
structure of the n- and o-glycans of the a-chain of human plasma alpha 2hs-glycoprotein as deduced from the chemical compositions of the derivatives prepared by stepwise degradation with exoglycosidases.	the structure of the glycans of the a-chain of human plasma alpha 2hs-glycoprotein was established from the chemical compositions of its derivatives prepared by sequential enzymatic degradation of the carbohydrate moiety, from the determination of the kind and amount of the monosaccharides liberated after each step of the enzymatic digestion, and from the distinct specificity of the highly purified exoglycosidases. the exoglycosidases were three sialidases (vibrio cholerae, fowl plague virus, an ...	1992	1457416
salmonella and vibrio cholerae in brackishwater cultured tropical prawns.	the occurrence of salmonella and vibrio cholerae in brackishwater ponds was monitored over a 2-year period in one of the major prawn exporting countries in southeast asia. the principal production areas were identified and regular samples taken for salmonella and v. cholerae analysis. results demonstrated that brackishwater ponds and cultured prawns were inherently contaminated with both bacterial pathogens. salmonella spp. were present in 16.0% of prawns and 22.1% of mud/water samples from pond ...	1992	1457289
distribution of 5-ht1 binding sites in cat spinal cord.	quantitative analysis of high affinity [3h]5-ht binding to 5-ht1 receptors in the cervical, thoracic, lumbar, and sacral spinal cord of the cat revealed specific binding throughout the grey matter, with the highest levels of binding in laminae ii and iii, and the lowest levels in laminae i and vii. relatively high levels were also observed in the thoracic intermediolateral cell column. there were no significant differences in the degree of binding between various segmental levels. comparison of ...	1992	1454202
[the comparative characteristics of vibrio cholerae hemolysins].	biochemical and biological properties of in vivo and in vitro hemolysins of cholera germs isolated by different authors as well as hemolysins of vibrio parahaemolyticus and escherichia coli have been comparatively characterized. according to the above data hemolysin of cholera germ el tor is a thermolabile protein with molecular mass of 60-80 thou.; it is cytotoxic, enteropathogenic and lyses all the species of erythrocytes. hemolysins of v. eltor and germs are immunologically related. hemolysin ...	1992	1453988
dna sequence determination and functional characterization of the oct-plasmid-encoded alkjkl genes of pseudomonas oleovorans.	the alkbfghjkl and alkst operons encode enzymes that allow pseudomonas putida (oleovorans) to metabolize alkanes. in this paper we report the nucleotide sequence of a 4592 bp region of the alkbfghjkl operon encoding the alkj, alkk and alkl polypeptides. the alkj gene encodes a protein of 59 kilodaltons. the predicted amino acid sequence shows significant homology with four flavin proteins: choline dehydrogenase, a glucose dehydrogenase and two oxidases. alkj is membrane-bound and converts alipha ...	1992	1453953
presidential politics and health care issues.		1987	1453420
cloning and expression in escherichia coli of the gene encoding an extracellular deoxyribonuclease (dnase) from aeromonas hydrophila.	the gene encoding an extracellular dnase from aeromonas hydrophila chc-1 has been cloned and sequenced. following expression of the dns in escherichia coli, it was revealed that some of the cloned enzyme was present in the cell-free extracellular supernatant fluid, and there was no cell lysis and concurrent release of cytoplasmic or periplasmic proteins. therefore, results suggest that e. coli cells were capable of secreting the dnase extracellularly, albeit very inefficiently. the dns is transc ...	1992	1452026
the use of mean platelet volume for evaluation of quality of platelet concentrates.	mean platelet volume (mpv) was determined on whole blood and platelet concentrates (pc) prepared from units of the same blood, as well as on samples of venous blood taken from donors before plateletpheresis and on pc collected by spectra (cobe laboratories ltd) and cs-3000 (baxter healthcare ltd) cell separators. the mean (+/- sd) mpv for pc prepared from blood (7.18 +/- 0.76 fl, n = 12) was significantly lower than that for whole blood (8.32 +/- 0.72 fl, p < 0.02) suggesting significant separat ...	2006	1450330
single determination of ca 15.3 and bone scintigraphy in the diagnosis of skeletal metastases of breast cancer.	single determination of ca 15.3 and bone scintigraphy were performed on the same day as follow-up procedures in 864 patients with breast cancer. the sensitivity and specificity of bone scintigraphy for skeletal metastases were 99% and 88.8%, respectively. the overall sensitivity and specificity of ca 15.3 (cut-off for pathological values greater than 30 u/ml) for cancer recurrence or distant metastases were 69.2% and 92.1%, respectively. the sensitivity of ca 15.3 for bone metastases was lower ( ...	2006	1450226
the prognostic value of fetal ultrasonography before induction of labour.	to investigate whether ultrasound examination of the fetus and amniotic fluid before induction of labour can provide useful prognostic information about the course of labour and mode of delivery.	2006	1450140
the relationship of pretreatment family functioning to drinking behavior during follow-up by alcoholic patients.	the relationship of alcoholics' perceptions of the pretreatment functioning of their families to drinking outcomes during an 18-month follow-up was examined. family functioning was hypothesized to be predictive of drinking behavior, particularly in subjects with low assertion of autonomy scores. these individuals report greater dependency and attachment, and therefore might be more affected by the state of important relationships. the results indicated that with low autonomy male alcoholics, gre ...	2005	1449124
the physiological stop pathway: target regulation of axonal growth.		2006	1449078
reaction cycle and thermodynamics in bacteriorhodopsin.	light causes the all-trans to 13-cis isomerization of the retinal in bacteriorhodopsin; the thermal relaxation leading back to the initial state drives proton transport first via proton transfer between the retinal schiff base and d85 and then between the schiff base and d96. the reaction sequence and thermodynamics of this photocycle are described by measuring time-resolved absorption changes with a gated multichannel analyzer between 100 ns and 100 ms, at six temperatures between 5 degrees c a ...	2006	1449068
molecular correlates of physiological regulation in a p-type h(+)-atpase.		1992	1449060
aging and immunity.	the function of the immune system peaks at around puberty and gradually declines thereafter with advance in age. the age-related decline of immunological function primarily occurs in the t cell-dependent immune system and is generally associated with increase in susceptibility to infections as well as in incidence of autoimmune phenomena in the elderly. the age-related change in t cell-dependent immune functions can be ascribed to the physiological thymic atrophy which starts in an early stage o ...	2006	1449050
diaphragmatic movement using ultrasound during spontaneous and mechanical ventilation: effect of tidal volume.	using ultrasound (us) the effect of various tidal volumes on the movement of ventral, dome and dorsal parts of the right hemidiaphragm was studied, both during spontaneous and mechanical ventilation. six healthy non-medicated volunteers who were in the supine position breathed spontaneously shallowly (tidal volume (vt) being 400 ml) (sb), and deeply (vt 1000 ml) (sb-deep). in addition, they were mechanically ventilated with intermittent positive pressure ventilation at three different vt's: 500 ...	2006	1449048
[pathomorphology of acute and chronic stages of ccl4-induced liver fibrosis: immunohistochemical and in situ hybridization studies].	the cellular localization of expression of various genes activated during the course of liver fibrosis and regeneration was studied by immunohistology and in situ hybridization in rat and human liver tissues. mesenchymal cells proved to be the principal sources of extracellular matrix proteins and of fibrogenic growth factors, whereas the collagenase-activating protease transin/stromelysin gene was transcribed in parenchymal cells as well. fibrogenesis by the mesenchymal compartment appears to b ...	1992	1449012
[ultrasound morphology of gallstones].	using a subtile examination technique genuine information can be obtained from the interior of a gallstone--at least to a depth of 15 mm. this information should provide an indication of the homogeneous (crystalline) or inhomogeneous (non-cholesterol) structure of the stone. further systematic use of differentiating gallstone ultrasonography could become a useful additional decision making criterion for selection of gallstones suitable for conservative treatment.	2006	1449008
prognostic indicators in fulminant hepatic failure.	because of the inhomogeneous prognosis in fulminant hepatic failure, prognostic criteria are required which help to establish the indication for liver transplantation as a successful therapeutic procedure. in our study of 33 patients with fulminant hepatic failure (94% viral hepatitis, 67% hepatitis b), serum bilirubin > 320 or < 160 mumol/l, serum creatinine > 110 mumol/l, prothrombin time < 15% of the normal value and duration of jaundice until onset of encephalopathy > 7 days indicated a fata ...	2006	1449004
[the level and cryoprecipitating activity of fibronectin in bronchial asthma patients].	125 patients with bronchial asthma were under observation. it has been established that the level of fibronectin decreases as of severity of clinical symptoms of the disease growth. parallelly cryoprecipitating activity of fibronectin decreases, testifying functional inferiority of the pointed glycoprotein in the patients with bronchial asthma. under the influence of undergoing therapy restoration of fibronectin concentration and its complex-forming ability takes place except of the hormone-depe ...	2006	1448982
applications of transcranial doppler sonography in acute ischemic stroke.		2004	1448837
[characteristics of the dynamics of hematopoietic precursor cells cloned in diffusion chambers and recorded in experiments on mice and dogs irradiated in median lethal doses].	in experiments with mice and dogs irradiated with ld50, it was shown the postirradiation depopulation of haemopoietic polypotent (cfus) cell-precursors in mouse bone marrow was more pronounced than that of granulocytic and macrophagal cells (cfudc). the rate of repopulation of cfus during the first week was higher than that of cfudc (t1/2 was 2.5 and 8.8 days respectively). in dogs, one could notice a partial change in the colony formation, a prolonged plateau period in the postirradiation cfudc ...	1992	1448562
treatment of peripheral tissue ischemia with topical nitroglycerin ointment in neonates.	four neonates had resolution of peripheral tissue ischemia after the application of 2% nitroglycerin ointment. a dosage of 4 mm nitroglycerin ointment per kilogram of body weight was applied to two patients with ischemia caused by vasospasm from indwelling radial artery catheterization and to two patients with ischemia resulting from dopamine extravasation. no adverse effects were noted except mild episodes of decreased blood pressure in two of the patients.	2006	1447671
how can the optometric profession expand the pool of qualified applicants?	the health professions, including optometry, are facing a declining applicant pool. the american optometric association has taken steps to address the challenge of increasing the pool of qualified applicants to the schools and colleges of optometry. however, the most significant factor in the process will be the efforts of individual aoa members.	2006	1447468
what are the appropriate skills and knowledge required for the entry-level practice of optometry?	all health professions have developed a national program of competence assessment to address the specific issue of "entry-level practice." this is also true in optometry through the 3-part examinations of the national board of examiners in optometry. these examinations test the cognitive (knowledge) skills necessary to be fit to practice and the communication, affective and psychomotor skills that are required to apply the underlying knowledge in the solution of patient problems. the scope of th ...	2006	1447457
ventilation is stimulated by small reductions in arterial pressure in the awake dog.	changes in arterial pressure commonly accompany respiratory adaptations. the purpose of this study was to determine, in awake dogs (n = 6), the degree to which small acute decreases in arterial pressure affect ventilation and acid-base balance. mean arterial pressure (map) was reduced by 6 +/- 2, 10 +/- 3, and 16 +/- 2% by intravenous infusion of sodium nitroprusside for sequential 20-min periods. in another experiment, the ventilatory response to hypercapnia was determined during map reduction ...	1992	1447103
accreditation process in the united kingdom.		2006	1447019
residency training in radiation oncology; radiation biology and cancer biology.		2006	1447014
principles of radiation oncology training and manpower requirements in canada.		2006	1447010
ergotamine-metoclopramide for migraine: is it enough?		2006	1446995
"raynaud's disease" in migraineurs: one entity or two?	two cases are reported of patients who were diagnosed as having both migraine and raynaud's disease. because they were able to achieve effective control of both headaches and extremity temperature after undergoing a comprehensive approach--utilizing medication, biofeedback, and psychotherapy--it is suggested that both conditions are manifestations of the same disorder. it is recommended that a first step in approaching concurrent diagnoses of this type involve combined treatment as is often used ...	2006	1446993
flunarizine in migraine: a double-blind placebo-controlled study (in a saudi population).	we evaluated the effect of flunarizine (fz) (10 mg/d) on migraine in a double-blind placebo-controlled design. the attacks' frequency, duration, severity and associated symptoms were compared before and after treatment. forty-two patients completed a three-month trial period; 21 patients received fz and 21 placebo. statistical analysis showed no significant difference between fz and placebo (p > 0.05). in this study fz was not more efficient than placebo in migraine.	2006	1446992
chronic daily headache: long-term prognosis following inpatient treatment with repetitive iv dhe.	we retrospectively studied the long-term (2-year) outcome of 50 consecutive patients admitted to our inpatient headache program because of chronic daily headache (cdh) associated with the overuse of analgesics, ergotamine, or both. they had been detoxified, given repetitive intravenous dihydroergotamine (iv dhe) and prophylactic medications as part of the program, and had become headache-free on this regimen. at the time of admission, 37 of the 50 patients had transformed migraine (tm), 12 had n ...	2006	1446987
cerebrospinal fluid pressure and venous pressure in "dynamite headache" and cluster headache attacks.	six patients with episodic cluster headache were investigated as to blood pressure, heart rate, cerebrospinal fluid pressure (pcsf) and frontal vein pressure (pvf) during five nitroglycerin (ng) provoked attacks and one spontaneous attack. in a seventh studied patient the ng failed to provoke an attack. the earlier reported decrease of systolic blood pressure and increase of diastolic blood pressure and heart rate after ng administration were also found in these patients. the "dynamite headache" ...	2006	1446986
cloning and sequencing of a human cdna coding for dihydroorotate dehydrogenase by complementation of the corresponding yeast mutant.	dihydroorotate dehydrogenase (dhodehase, ec 1.3.3.1) catalyses the fourth enzymatic step in de novo pyrimidine biosynthesis. a truncated human cdna encoding this enzyme was isolated from a hela cell cdna library by functional complementation of a corresponding deletion mutant from the yeast, saccharomyces cerevisiae. the complementing clone contained a 1.5-kb poly(a)(+)-tailed insert with a 1191-bp open reading frame, hybridising with a unique human mrna of 1.6 kb. the deduced amino acid sequenc ...	1992	1446837
catalytic oxidation of 2,4,5-trihydroxyphenylalanine by tyrosinase: identification and evolution of intermediates.	the oxidation of 3,4-dihydroxyphenylalanine (dopa) by o2 catalyzed by tyrosinase yields 4-(2-carboxy-2-aminoethyl)-1,2-benzoquinone, with its amino group protonated (o-dopaquinone-h+). this evolves non-enzymatically through two branches (cyclization and/or hydroxylation), whose respective operations are determined by ph. the hydroxylation branch of o-dopaquinone-h+ only operates significantly at ph < or = 5.0 and involves the accumulation of 2,4,5-trihydroxyphenylalanine (topa), which has been d ...	1975	1445949
identification of the ubiquinone-binding site of nadh:ubiquinone oxidoreductase (complex i) from neurospora crassa.	in order to localize the ubiquinone-binding site of complex i (nadh:ubiquinone oxidoreductase), a novel photoreactive ubiquinone analogue (q0c7arn3) has been synthesized. it is shown that the direct chemical precursor of this analogue (q0c7arno2) and the analogue itself are accepted as substrates in an enzyme assay utilizing ubiquinone-depleted mitochondrial membranes of neurospora crassa. the activity of the enzyme applying these derivatives is inhibited by 50% at a concentration of 9 and 20 mi ...	1975	1445878
induction of melanin biosynthesis in vibrio cholerae.	vibrio cholerae synthesized the pigment melanin in response to specific physiological conditions that were stressful to the bacterium. pigmentation was induced when v. cholerae was subjected to hyperosmotic stress in conjunction with elevated growth temperatures (above 30 degrees c). the salt concentration tolerated by v. cholerae was lowered by additional abiotic factors such as acidic starting ph of the growth medium and limitation of organic nutrients. although the amount of toxin detected in ...	1992	1444398
the mapping by high-ph anion-exchange chromatography with pulsed amperometric detection and capillary electrophoresis of the carbohydrate moieties of human plasma alpha 1-acid glycoprotein.	the reducing oligosaccharides released from alpha 1-acid glycoprotein (agp) by conventional hydrazinolysis have been analyzed by two different mapping techniques, using high-ph anion-exchange chromatography with pulsed amperometric detection (hpae-pad) and capillary electrophoresis (ce) with uv detection at 190 nm. the ce measurements proved about 4000 times more sensitive than the measurements by hpae-pad. the n-glycan pool was fractionated by mono q anion-exchange chromatography, and individua ...	1992	1443615
[ticlid--a new development in the treatment and prevention of arterial thromboses].		2006	1440322
a periplasmic protein disulfide oxidoreductase is required for transformation of haemophilus influenzae rd.	the mutated gene in jg16, a haemophilus influenzae strain deficient in competence-induced dna binding and uptake, was cloned and the wild-type allele was sequenced. the gene was shown by northern analysis to be constitutively expressed on a 1.7-kilobase transcript. the gene product was identified as a 20.6-kda protein targeted to the periplasm. the protein contains the sequence cys-pro-his-cys (cphc) and is highly similar to two other periplasmic cphc motif-containing proteins: dsba, an escheric ...	1992	1438213
kinetic studies of the mechanism of thrombocytopenia in patients with human immunodeficiency virus infection.	isolated thrombocytopenia accompanied by increased amounts of platelet-associated antibody is a common manifestation of human immunodeficiency virus (hiv) infection, and the thrombocytopenia often improves with zidovudine. it is not clear whether the mechanism of hiv-related thrombocytopenia primarily involves autoimmune destruction of platelets or reduced platelet production by megakaryocytes.	1992	1435932
treatment of preterm labor with the beta-adrenergic agonist ritodrine.		2006	1435926
tragedy of the commonplace: the impact of addiction on families in the fiction of thomas hardy.		2006	1434778
[effect of ph on preferential antibacterial-activity of ethylenediaminetetraacetic acid (edta)].	ethylenediaminetetraacetic acid (edta), a chelating agent, was examined for the antibacterial activity against 15 species of bacteria by treating with a 10mm solution at ph adjusted to 5.0, 7.0 or 9.0. all bacterial species tested were classified into three groups; tentatively named the ph5 edta-sensitive group comprising vibrio cholerae and staphylococcus aureus, the ph9 edta-sensitive group comprising escherichia coli and pseudomonas aeruginosa and the edta-nonsensitive group comprising proteu ...	1992	1433911
food allergy--fact or fiction: a review.	food sensitivity is a common condition presenting with various clinical syndromes including migraine, urticaria, gluten enteropathy, crohn's disease and irritable bowel syndrome. it is a heterogeneous condition affecting different organ systems and is also aetiologically diverse with subgroups due to allergy, pharmacological reactions, enzyme deficiencies and psychological causes. clinical acceptance of food sensitivity has been delayed by the use of dubious diagnostic techniques by a minority o ...	1987	1433127
impact of zinc supplementation on intestinal permeability in bangladeshi children with acute diarrhoea and persistent diarrhoea syndrome.	zinc has been shown to enhance intestinal mucosal repair in patients suffering from acrodermatitis enteropathica; but the impact on mucosal integrity during acute (ad) or persistent (pd) diarrhoea is unknown. one hundred eleven children with ad and 190 with pd aged between 3 and 24 months received, randomly and blind to the investigators, either an elemental zinc supplement of 5 mg/kg body wt/day or placebo in multivitamin syrup for 2 weeks while intestinal permeability and, biochemical and anth ...	1992	1432467
increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration.	repeated administration of cocaine enhances several of the behavioral and neurochemical responses to subsequent cocaine injections, an effect that has been attributed, in part, to decreased somatodendritic autoreceptor sensitivity of mesocorticolimbic dopamine (da) neurons. such changes in autoregulation may not only modify the direct effects of cocaine on extracellular da levels but also result in tonically increased basal da release in the terminal areas of the mesocorticolimbic da system. the ...	1992	1432099
outbreak of cholera associated with crab brought from an area with epidemic disease.	from 31 march through 3 april 1991, 8 new jersey residents developed severe, watery diarrhea after eating crabmeat brought back in the suitcase of a traveler to ecuador. stool cultures yielded toxigenic vibrio cholerae o1, serotype inaba, biotype el tor from 4 persons, and vibriocidal antibody titers were > or = 1:640 in 7 persons, indicating recent infection with vibrio cholerae o1. eating crab was statistically associated with illness (p = .006); however, no leftover crabmeat was available for ...	1992	1431260
cholera in piura, peru: a modern urban epidemic.	in late january 1991, epidemic cholera appeared in peru. within 2 months, 7922 cases and 17 deaths occurred in piura, a peruvian city of 361,868. a hospital-based culture survey showed that 79%-86% of diarrhea cases were cholera. high vibriocidal antibody titers were detected in 34% of the asymptomatic population. a study of 50 case-patients and 100 matched controls demonstrated that cholera was associated with drinking unboiled water (odds ratio [or], 3.9; 95% confidence interval [ci], 1.7-8.9) ...	1992	1431259
acute secretory travellers' diarrhoea caused by vibrio cholerae non-01 which does not produce cholera-like or heat-stable enterotoxins.	an australian tourist suffering from severe acute watery diarrhoea and dehydration due to vibrio cholerae non-01 was studied. the v. cholerae strain isolated from the patient belonged to serovar 05. the organism did not produce any of the conventional enterotoxins including cholera-toxin (ct) or heat-stable toxins (nag-st) that are known to be associated with intestinal secretion. this report suggests that toxin(s) other than ct-like or nag-st may be involved in the pathogenesis of diarrhoea by ...	1992	1430972
cloning of a metalloprotease gene involved in the virulence mechanism of vibrio anguillarum.	genetic evidence has previously suggested that a zinc metalloprotease is involved in the invasive mechanism of the fish pathogen vibrio anguillarum nb10. in this study, the metalloprotease gene was cloned and sequenced. the sequence encodes a polypeptide (611 amino acids) that contains a putative signal sequence followed by a large leader sequence and the mature protein (44.6 kda). since the purified protein has a molecular mass of 36 kda instead of the predicted 44.6 kda, the mature protein is ...	1992	1429449
candida albicans--saprophyte or pathogen?	skin scrapings taken from toe spaces of 200 healthy volunteers and from toe webs and groins of 150 pediatric patients were cultured for candida albicans using the serum germ-tube test. the results showed that candida albicans can be isolated in about 15% of normal toe spaces and 14% of children with normal groins. although candida albicans can be found in various grades of athlete's foot and also in some abnormal groins, we believe that it is not necessarily responsible for these conditions and ...	1992	1428429
expression of transforming growth factor-beta (tgf-beta 1) and insulin-like growth factor ii (igf-ii) messenger rna in the developing subcutaneous tissue (sq) of the fetal pig.	studies (in situ hybridization) were performed on the developing subcutaneous tissue (sq) of the pig fetus to determine sites of synthesis of tgf-beta 1 and igf-ii. tissues from 50, 70, 90, 110-day-old pig fetuses and 7-day-old postnatal pigs were bouin's fixed, paraffin embedded and hybridized with biotin labelled cdna probes. the expression of tgf-beta 1 messenger rna was detectable primarily in the dermis, hair follicle fat lobule, outer and inner sq areas at all ages. cells adjacent to adipo ...	1992	1428415
a non-invasive technique for the accurate measurement of leg length in animals.	a novel, non-invasive technique for accurate measurements in animals (kyniklometry) is presented. kyniklometry (derived from greek ŏ kúvikloz the rabbit) determines the distance between soft tissue landmarks in conscious rabbits, in particular the rear lower leg. each measurement consists of six subsequent and independent estimations of this distance, with a technical error of 79 microns (study i), respectively 83 microns (study ii). the angle of the relaxed sitting animal's knee is approximatel ...	1992	1428414
novel surface molecules involved in human nk cell activation and triggering of the lytic machinery.	three new monoclonal antibodies (mabs) termed 7a6, pp35 and a6/143 were isolated after mouse immunization with cd3- cd16+ nk clones. the screening procedure was based on the ability of mabs to trigger cytolytic activity of the immunizing clones in a re-directed killing assay against the p815 murine mastocytoma cell line. the 7a6 mab reacts with 58 kda surface molecules that appear to belong to the same molecular family defined by the previously described nk-sub-set-specific gl183 and eb6 mabs. h ...	1992	1428407
functional assembly of chimeric t-cell receptor chains.	we have generated cytotoxic t-cell hybridomas expressing chimeric t-cell receptors (ctcr) with an antibody-type specificity for the tnp hapten. transfectants expressing the ctcr genes could mediate specific lysis of haptenated tumor cell lines of various types and secrete il-2 upon stimulation with tnp modified cells. in a previous report, we showed that double-gene transfectants expressing either vhc alpha and vlc beta or vhc beta and vlc alpha could be activated by tnp-modified stimulator cell ...	2006	1428405
psychological effects during reduced training volume and intensity in distance runners.	improved mood state has ben linked with reduced training (rt). however, rt has been measured only as a reduction in training volume, either maintaining or not considering the intensity of training employed. to investigate the effects of a 4-week reduction in both training volume and intensity on running performance and mood state, 10 well-trained adult male runners trained for 4 weeks at baseline training distance and pace (bt), followed by 4 weeks training reduced in volume by 66%, with intensi ...	2006	1428383
chloramphenicol resistant s. typhi.		1992	1428156
benign cystic teratoma of the mediastinum.		2006	1428151
experience with a measles vaccine manufactured in india.	five hundred and twenty seven children between 7 months and 2 years of age were vaccinated with measles vaccine manufactured by the serum institute of india. the sero-conversion rate in children who had no antibodies previous to vaccination was 98.4% as tested in hi. ninety per cent of children who had pre-vaccination measles antibodies showed a two-fold or more rise in hi antibodies. the side reactions of the vaccine were negligible.	1992	1428138
development and evaluation of a rapid, simple, sensitive, monoclonal antibody-based co-agglutination test for direct detection of vibrio cholerae 01.	cholera epidemics caused by vibrio cholerae 01 continue to represent a major public health concern in many developing countries. a rapid and simple test kit for the detection of v. cholerae 01 has been developed. the kit, cholerascreen is a monoclonal antibody-based, co-agglutination test and is used directly with stool specimens. it does not include culturing the specimen and is performed without the need for sophisticated laboratory equipment. specificity of the test was demonstrated, using 11 ...	1992	1427010
the nysb sund double mutant of dictyostelium discoideum is blocked in the acquisition of non-degradative resistance to the pea phytoalexin pisatin.	dictyostelium discoideum amoebae can be induced to acquire a non-degradative resistance to the pea phytoalexin pisatin. the nysb sund double mutant is blocked in the acquisition of this resistance. using parasexual genetics it has been shown that sund is a recessive mutation linked to nysb on linkage group vi.	1992	1426988
effect of lipid peroxidation on molecular arrangement of phospholipids in liposomes prepared from egg yolk phosphatidylcholine or total rat brain lipids. a 31p nmr study.	changes in molecular arrangement of membrane phospholipids in the course of lipid autoxidation were studied by means of broad-band 31-p nmr spectroscopy. multilamellar liposomes prepared from egg yolk phosphatidylcholine (pc) or total lipid extracts from rat brains (tl) were used as models. the initial lamellar arrangement of phospholipids of both types changed as lipid peroxidation proceeded and a narrow isotropic signal appeared in the spectra at 0 ppm, this phenomenon being more prominent for ...	1992	1426979
purification and characterization of a feruloyl/p-coumaroyl esterase from solid-state cultures of the aerobic fungus penicillium pinophilum.		1992	1426561
the regulation of microsomal glucose-6-phosphatase differs between liver and kidney.		1992	1426558
studies on the mechanism of the inhibition of lipogenesis by growth hormone in sheep adipose tissue.		1992	1426557
neuronal expression of the tissue specific splicing protein smn and its possible role in pre mrna splicing.		1992	1426556
reconstitution and kinetics of vacuolar h(+)-translocating atpases from plants and animals.		1992	1426540