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[optic chiasm glioma in children: endocrine disorders in 14 cases].to describe the frequency of endocrine disorders in children with optic chiasm glioma and analyze related factors.201626971985
how often and when fisher syndrome is overlapped by guillain-barré syndrome or bickerstaff brainstem encephalitis?fisher syndrome (fs) may overlap with guillain-barré syndrome (gbs), in particular the pharyngeal-cervical-brachial variant form (pcb-gbs), or bickerstaff brainstem encephalitis (bbe). our aim was to elucidate the frequency of this overlap and the patterns of clinical progression in patients with fs.201626969889
genetic diversity of plasmodium falciparum isolates from concurrent malaria and arbovirus co-infections in kedougou, southeastern senegal.concurrent malaria and arbovirus infections are common and represent an important public health concern in regions where both diseases are endemic. the present study investigates the genetic diversity and complexity of plasmodium falciparum infection in concurrent malaria-arbovirus infections in kedougou region, southeastern senegal.201626969623
predictors of malignancy in hyperechoic breast lesions.hyperechogenicity has been strongly associated with benign breast lesions. although it is correct in most cases, hyperechogenicity must not always be considered synonymous with benignancy, as hyperechoic breast cancers do occur. the purpose of this study was to review clinical and imaging characteristics of hyperechoic breast lesions, looking for features associated with malignancy.201626969597
increased risk of delayed cerebral ischemia in subarachnoid hemorrhage patients with additional intracerebral hematoma.objective delayed cerebral ischemia (dci) has a major impact on the outcome of patients suffering from aneurysmal subarachnoid hemorrhage (sah). the aim of this study was to assess the influence of an additional intracerebral hematoma (ich) on the occurrence of dci. methods the authors conducted a single-center retrospective analysis of cases of sah involving patients treated between 2006 and 2011. patients who died or were transferred to another institution within 10 days after sah without the ...201726967776
fibrofatty changes: incidence at cardiac mr imaging in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy.purpose to determine the incidence of ventricular fatty replacement and late gadolinium enhancement (lge) at cardiac magnetic resonance (mr) imaging in patients with arrhythmogenic right ventricular (rv) dysplasia/cardiomyopathy (arvd/c) and the relationship of these findings to disease severity. materials and methods this was a retrospective institutional review board-approved hipaa-compliant study. all subjects provided written informed consent. seventy-six patients with arvd/c were enrolled f ...201626967143
prevalence and location of neuropathic pain in lumbar spinal disorders: analysis of 1804 consecutive patients with primary lower back pain.a cross-sectional study of 1804 consecutive patients.201626967122
analysis of biopsies from duodenal bulbs of all endoscopy patients increases detection of abnormalities but has a minimal effect on diagnosis of celiac disease.in patients with positive results from serologic tests for celiac disease, analysis of tissues samples from the duodenal bulb, in addition to those from other parts of the small bowel, might increase the diagnostic yield. however, biopsies are not routinely collected from the duodenal bulb because of concerns that villous atrophy detected there could be caused by other disorders (brunner glands or peptic duodenitis, gastric metaplasia, shorter villi, or lymphoid follicles). we investigated wheth ...201626965842
pettsy: a computational tool for perturbation analysis of complex systems biology models.over the last decade sensitivity analysis techniques have been shown to be very useful to analyse complex and high dimensional systems biology models. however, many of the currently available toolboxes have either used parameter sampling, been focused on a restricted set of model observables of interest, studied optimisation of a objective function, or have not dealt with multiple simultaneous model parameter changes where the changes can be permanent or temporary.201626964749
fish rejections in the marine aquarium trade: an initial case study raises concern for village-based fisheries.a major difficulty in managing wildlife trade is the reliance on trade data (rather than capture data) to monitor exploitation of wild populations. collected organisms that die or are rejected before a point of sale often go unreported. for the global marine aquarium trade, identifying the loss of collected fish from rejection, prior to export, is a first step in assessing true collection levels. this study takes a detailed look at fish rejections by buyers before export using the papua new guin ...201626963259
predictors of good functional outcomes and mortality in patients with severe rebleeding after aneurysmal subarachnoid hemorrhage.aneurysmal rebleeding is a major cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (asah); however, limited data on severity of rebleeding and outcomes after severe rebleeding are available. we aimed to determine predictors of good outcome and mortality after severe rebleeding.201626963087
protocol based real-time continuous electroencephalography for detecting vasospasm in subarachnoid hemorrhage.a continuous electroencephalography (ceeg) can be helpful in detecting vasospasm and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage (sah). we describe a patient with an aneurysmal sah whose symptomatic vasospasm was detected promptly by using a real-time ceeg. patient was immediately treated by intraarterial vasodilator therapy. a 50-year-old woman without any significant medical history presented with a severe bifrontal headache due to acute sah with a ruptured aneurysm on the ...201626962422
extracellular vesicle proteomes reflect developmental phases of bacillus subtilis.extracellular vesicles (ev) are spherical membrane-bound vesicles with nano-scale diameters, which are shed to the extracellular region by most eukaryotic and prokaryotic cells. bacterial ev are proposed to contribute to intercellular communication, bacterial survival and human pathogenesis as a novel secretion system. ev have been characterized from many gram-negative species and, more recently, from several vegetative gram-positive bacteria. further characterization of ev and their molecular c ...201626962304
nutrition delivery affects outcomes in pediatric acute respiratory distress syndrome.malnutrition is prevalent in critically ill children. we aim to describe nutrition received by children with acute respiratory distress syndrome (ards) and to determine whether provision of adequate nutrition is associated with improved clinical outcomes.201626962064
convection-enhancement delivery of liposomal formulation of oxaliplatin shows less toxicity than oxaliplatin yet maintains a similar median survival time in f98 glioma-bearing rat model.results of clinical trials with oxaliplatin in treating glioblastoma are dismal. previous works showed that intravenous (i.v.) delivery of oxaliplatin did not increase the survival of f98 glioma-bearing fisher rats. low accumulation of the drug in tumor cells is presumed to be responsible for the lack of antitumor effect. in the present study, convection-enhanced delivery (ced) was used to directly inject oxaliplatin in brain tumor implanted in rats. since ced can led to severe toxicity, the lip ...201626961906
disruption of stat5b-regulated sexual dimorphism of the liver transcriptome by diverse factors is a common event.signal transducer and activator of transcription 5b (stat5b) is a growth hormone (gh)-activated transcription factor and a master regulator of sexually dimorphic gene expression in the liver. disruption of the gh hypothalamo-pituitary-liver axis controlling stat5b activation can lead to metabolic dysregulation, steatosis, and liver cancer. computational approaches were developed to identify factors that disrupt stat5b function in a mouse liver gene expression compendium. a biomarker comprised of ...201626959975
harvest pressure on coastal atlantic cod (gadus morhua) from recreational fishing relative to commercial fishing assessed from tag-recovery data.marine recreational fishing is a popular outdoor activity. however, knowledge about the magnitude of recreational catches relative to commercial catches in coastal fisheries is generally sparse. coastal atlantic cod (gadus morhua) is a target species for recreational fishers in the north atlantic. in norway, recreational fishers are allowed to use a variety of traps and nets as well as long-line and rod and line when fishing for cod. from 2005 to 2013, 9729 cod (mean size: 40 cm, range: 15-93 cm ...201626959371
comparison of battery-powered and manual bone biopsy systems for core needle biopsy of sclerotic bone lesions.the purpose of this study was to compare manual and battery-powered bone biopsy systems for diagnostic yield and procedural factors during core needle biopsy of sclerotic bone lesions.201626959290
cervical pessary and vaginal progesterone in twin pregnancies with a short cervix.to evaluate cervical pessary as an intervention to prevent preterm birth in twin pregnancies with a short cervix.201626959202
data defining markers of human neural stem cell lineage potential.neural stem cells (nscs) and neural progenitor cells (npcs) are self-renewing and multipotent cells, however, npcs are considered to be more lineage-restricted with a reduced self-renewing capacity. we present data comparing the expression of 21 markers encompassing pluripotency, self-renewal (nsc) as well as neuronal and glial (astrocyte and oligodendrocyte) lineage specification and 28 extracellular proteoglycan (pg) genes and their regulatory enzymes between embryonic stem cell (esc)-derived ...201626958640
pharyngocutaneous fistula: the incidence and the risk factors.a pharyngocutaneous fistula is the most common complication following laryngectomy. a wide range of potential risk factors has been suggested. the purpose of this study was to determine the incidence and risk factors for the fistula at the department of otorhinolaryngology and head and neck surgery in ljubljana, slovenia between 2007 and 2012. charts from patients treated for head and neck cancer by laryngectomy were retrospectively reviewed. comprehensive clinicopathologic data were collected i ...201626956981
contribution of the anaphylatoxin receptors, c3ar and c5ar, to the pathogenesis of pulmonary fibrosis.complement activation, an integral arm of innate immunity, may be the critical link to the pathogenesis of idiopathic pulmonary fibrosis (ipf). whereas we have previously reported elevated anaphylatoxins-complement component 3a (c3a) and complement component 5a (c5a)-in ipf, which interact with tgf-β and augment epithelial injury in vitro, their role in ipf pathogenesis remains unclear. the objective of the current study is to determine the mechanistic role of the binding of c3a/c5a to their res ...201626956419
the effect of occupational noise exposure on blood and biochemical parameters: a case study of an insulator manufacturer in iran.occupational noise is among the most critical occupational hazards, which, in addition to hearing loss, can cause other adverse consequences on an individual's physical and mental health. long-term exposure to noise can affect blood and biochemical parameters and subsequently lead to increased risk of cardiovascular disease. this study investigated the effect of occupational exposure to noise on blood and biochemical parameters of workers in an insulator manufacturing plant.201626955444
dental panoramic indices and fractal dimension measurements in osteogenesis imperfecta children under pamidronate treatment.to verify radiomorphometric indices and fractal dimension (fd) in dental panoramic radiographs (dprs) of children with different types of osteogenesis imperfecta (oi) and also to verify the effect of pamidronate (pam) treatment in such panoramic analyses.201626954289
25-hydroxyvitamin d in pregnancy and genome wide cord blood dna methylation in two pregnancy cohorts (moba and alspac).the aim of the study was to investigate whether maternal mid-pregnancy 25-hydroxyvitamin d concentrations are associated with cord blood dna methylation. dna methylation was assessed using the illumina humanmethylation450 beadchip, and maternal plasma 25-hydroxyvitamin d was measured in 819 mothers/newborn pairs participating in the norwegian mother and child cohort (moba) and 597 mothers/newborn pairs participating in the avon longitudinal study of parents and children (alspac). across 473,731c ...201626953979
trauma team discord and the role of briefing.briefing of the trauma team before patient arrival is unstructured in many centers. we surveyed trauma teams regarding agreement on patient care priorities and evaluated the impact of a structured, physician-led briefing on concordance during simulated resuscitations.201626953754
impact of consensus statements and reimbursement on vena cava filter utilization.pulmonary embolism is the third most common cause of death in hospitalized patients. vena cava filters (vcfs) are indicated in patients with venous thromboembolism with a contraindication to anticoagulation. prophylactic indications are still controversial. however, the utilization of vcfs during the past 15 years may have been affected by societal recommendations and reimbursement rates. the aim of this study was to evaluate the impact of societal guidelines and reimbursement on national trends ...201626952000
stent-assisted coiling versus coiling alone of poor-grade ruptured intracranial aneurysms: a multicenter study.endovascular coiling is a valid treatment option for poor-grade ruptured aneurysms. however, little is known about stent-assisted coiling of poor-grade aneurysms.201726951385
single-cell phenotype classification using deep convolutional neural networks.deep learning methods are currently outperforming traditional state-of-the-art computer vision algorithms in diverse applications and recently even surpassed human performance in object recognition. here we demonstrate the potential of deep learning methods to high-content screening-based phenotype classification. we trained a deep learning classifier in the form of convolutional neural networks with approximately 40,000 publicly available single-cell images from samples treated with compounds f ...201626950929
characterization of particle exposure in ferrochromium and stainless steel production.this study describes workers' exposure to fine and ultrafine particles in the production chain of ferrochromium and stainless steel during sintering, ferrochromium smelting, stainless steel melting, and hot and cold rolling operations. workers' personal exposure to inhalable dust was assessed using iom sampler with a cellulose acetate filter (aawp, diameter 25 mm; millipore, bedford, ma). filter sampling methods were used to measure particle mass concentrations in fixed locations. particle numbe ...201626950803
nox2 and cyclosporine-induced renal hypoxia.we hypothesized that nicotinamide adenosine diphosphate oxidase 2 (nox2) plays an important role in cyclosporine a (csa)-induced chronic hypoxia.201626950727
efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial.in critically ill patients, antibiotic therapy is of great importance but long duration of treatment is associated with the development of antimicrobial resistance. procalcitonin is a marker used to guide antibacterial therapy and reduce its duration, but data about safety of this reduction are scarce. we assessed the efficacy and safety of procalcitonin-guided antibiotic treatment in patients in intensive care units (icus) in a health-care system with a comparatively low use of antibiotics.201626947523
chemical characterization of the acid alteration of diesel fuel: non-targeted analysis by two-dimensional gas chromatography coupled with time-of-flight mass spectrometry with tile-based fisher ratio and combinatorial threshold determination.the illicit chemical alteration of petroleum fuels is of keen interest, particularly to regulatory agencies that set fuel specifications, or taxes/credits based on those specifications. one type of alteration is the reaction of diesel fuel with concentrated sulfuric acid. such reactions are known to subtly alter the chemical composition of the fuel, particularly the aromatic species native to the fuel. comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry ...201626947161
the effect of wavelength on endothermal heat-induced thrombosis incidence after endovenous laser ablation.we hypothesized that the incidence of endothermal heat-induced thrombosis (ehit) depends on the laser wavelength used in endovenous laser ablation (evla) of the saphenous veins.201626946893
histopathological grading systems analysis of oral squamous cell carcinomas of young patients.to analyze the clinicopathological profile of young patients (≤ 40 years) with oral scc and correlate with a control group (≥ 50 years) by means of histopathological grading systems.201626946200
elevation of serum cxc chemokine ligand-12 levels predicts poor outcome after aneurysmal subarachnoid hemorrhage.cxc chemokine ligand-12 (cxcl12) is involved in the innate immune system. elevation of its level in the peripheral blood is associated with severity and outcome of ischemic stroke. this study aimed to investigate its relation to severity and prognosis following aneurysmal subarachnoid hemorrhage (asah).201626944117
prevention of incisional hernias by prophylactic mesh-augmented reinforcement of midline laparotomies for abdominal aortic aneurysm treatment: a randomized controlled trial.the incidence of incisional hernias after abdominal aortic aneurysm repair is high. prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high risk of incisional hernia.201626943336
carbamazepine and carbamazepine-10,11-epoxide clearance measurements during continuous venovenous hemofiltration in a massive overdose.carbamazepine (cbz) overdose can result in significant neurologic and cardiovascular toxicity, and is compounded by the presence of an active metabolite, carbamazepine-10,11-epoxide (cbze). existing publications describing continuous venovenous hemofiltration (cvvh) in cbz overdose are limited in their ability to calculate accurate clearances. we report a case of cbz overdose treated with cvvh with detailed measurement of cbz, cbze and their respective clearances calculated utilizing serial effl ...201626942940
the prevalence, attitudes, and correlates of waterpipe smoking among high school students in iran: a cross-sectional study.the purpose of the present study was to determine the correlates of waterpipe (wp) smoking among 15-17-year-old high school students in iran.201626940816
acoustic radiation force impulse sonography in assessing children with biliary atresia for liver transplantation.children with biliary atresia are prone to developing progressive hepatic fibrosis and biliary cirrhosis following the kasai operation. the only treatment is liver transplantation.201626939975
do artisanal fishers perceive declining migratory shorebird populations?this paper discusses the results of ethno-ornithological research conducted on the local ecological knowledge (lek) of artisanal fishers in northeast brazil between august 2013 and october 2014.201626939745
data from camera surveys identifying co-occurrence and occupancy linkages between fishers (pekania pennanti), rodent prey, mesocarnivores, and larger predators in mixed-conifer forests.these data provide additional information relevant to the frequency of fisher detections by camera traps, and single-season occupancy and local persistence of fishers in small patches of forest habitats detailed elsewhere, "landscape fuel reduction, forest fire, and biophysical linkages to local habitat use and local persistence of fishers (pekania pennanti) in sierra nevada mixed-conifer forests" [10]. the data provides insight on camera trap detections of 3 fisher predators (bobcat [lynx rufus ...201626937448
c1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy.guillain-barré syndrome (gbs) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options. the pathogenesis of the acute motor axonal neuropathy (aman) variant is mediated by complement-fixing anti-ganglioside antibodies that directly bind and injure the axon at sites of vulnerability such as nodes of ranvier and nerve terminals. consequently, the complement cascade is an attractive target to ...201626936605
partial orbit irradiation achieves excellent outcomes for primary orbital lymphoma.primary radiation therapy (rt) achieves excellent local control and overall survival when treating localized orbital lymphoma. however, evidence supporting irradiation of partial orbit volumes to spare nearby critical structures is lacking. we sought to investigate outcomes for patients with localized orbital lymphoma treated with partial orbit irradiation.201726935235
mri detection of extramural venous invasion in rectal cancer: correlation with histopathology using elastin stain.the purpose of this article is to evaluate the diagnostic performance of mri for detection of extramural venous invasion (emvi) compared with histopathologic analysis using elastin stain.201626933769
results of early cranial decompression as an initial approach for damage control therapy in severe traumatic brain injury in a hospital with limited resources.severe traumatic brain injury (stbi) is a disease that generates significant mortality and disability in latin america, and specifically in colombia. the purpose of this study was to evaluate the 12-month clinical outcome in patients with stbi managed with an early cranial decompression (ecd) as the main procedure for damage control (dc) therapy, performed in a university hospital in colombia over a 4-year period.201726933337
analysis of 27 y-chromosomal str haplotypes in a han population of henan province, central china.a total of 1225 unrelated han males from henan province were analyzed with the prototype yfiler® plus kit (life technologies, thermo fisher scientific, waltham, ma, usa). the calculated gene diversity (gd) values ranged from 0.3855 to 0.9673 for the dys391 and dys385a/b loci, respectively. the discriminatory capacity (dc) was 86.94 % with 1065 observed haplotypes using 17 yfiler loci, by the addition of 10 y-strs to the yfiler® plus system, the dc was increased to 98.94 % while showing 1212 obse ...201626932866
the provision of oral hygiene instructions and patient motivation in a dental care system without dental hygienists.oral hygiene instructions (ohi) and patient motivation (pm), often provided by dental hygienists, are essential attributes to establishing good oral health in patients. the purpose of this study was to investigate the provision of ohi and pm by dental professionals in a dental care system without dental hygienists.201626932773
the energy-level crossing behavior and quantum fisher information in a quantum well with spin-orbit coupling.we study the energy-level crossing behavior in a two-dimensional quantum well with the rashba and dresselhaus spin-orbit couplings (socs). by mapping the soc hamiltonian onto an anisotropic rabi model, we obtain the approximate ground state and its quantum fisher information (qfi) via performing a unitary transformation. we find that the energy-level crossing can occur in the quantum well system within the available parameters rather than in cavity and circuit quantum eletrodynamics systems. fur ...201626931762
weakly supervised object localization with multi-fold multiple instance learning.object category localization is a challenging problem in computer vision. standard supervised training requires bounding box annotations of object instances. this time-consuming annotation process is sidestepped in weakly supervised learning. in this case, the supervised information is restricted to binary labels that indicate the absence/presence of object instances in the image, without their locations. we follow a multiple-instance learning approach that iteratively trains the detector and in ...201726930676
altered heart proteome in fructose-fed fisher 344 rats exposed to bisphenol a.bisphenol a (bpa), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. exposure-related reproductive disorders have been found, but recently it has also been suggested that bpa may be involved in obesity, diabetes, myocardial hypertrophy and myocardial infarction in humans. to mimic a modern lifestyle, female rats were fed with fructose or fructose plus bpa (0.25mg/l drinking water). the myocardial left ventricle ...201626930160
posterior reversible encephalopathy syndrome following immunoglobulin therapy in a patient with miller-fisher syndrome. 201726929465
reply: pharyngeal-cervical-brachial/miller-fisher overlap: a possible central variant. 201626926844
[status and influencing factors of rush poppers use and hiv infection among men who have sex with men in changsha].to explore the relationship between use of rush poppers and hiv infection, and associated factors among men who have sex with men in changsha.201626926723
prediction of additional lymph node involvement in breast cancer patients with positive sentinel lymph nodes.axillary lymph node dissection (alnd) has traditionally been the principal method for evaluating axillary lymph node status in breast cancer patients. in the past decades sentinel lymph nodes biopsy after lymphatic mapping has been used to stage the disease. the majority of sentinel lymph nodes (sln) positive patients do not have additional metastases in non-sentinel nodes (non-sln) after additional alnd. these patients are exposed to the morbidity of alnd without any benefit from additional axi ...201626925789
granisetron versus granisetron-dexamethasone for prevention of postoperative nausea and vomiting in pediatric strabismus surgery: a randomized double-blind trial.aim. efficacy of granisetron and combination of granisetron and dexamethasone was evaluated for prevention of postoperative nausea and vomiting (ponv) in children undergoing elective strabismus surgery. methods. a total of 136 children (1-15 years) were included. children received either granisetron (40 mcg/kg) [group g] or combination of granisetron (40 mcg/kg) and dexamethasone (150 mcg/kg) [group gd]. intraoperative fentanyl requirement and incidence and severity of oculocardiac reflex were a ...201626925101
semantic ambiguity and syntactic bootstrapping: the case of conjoined-subject intransitive sentences.when learning verb meanings, learners capitalize on universal linguistic correspondences between syntactic and semantic structure. for instance, upon hearing the transitive sentence "the boy is glorping the girl" two-year olds prefer a two-participant event (e.g., a boy making a girl spin) over two simultaneous one-participant events (a boy and a girl separately spinning). however, two- and three-year-olds do not consistently show the opposite preference when hearing conjoined-subject intransiti ...201626924950
drivers of the distribution of fisher effort at lake alaotra, madagascar.understanding how fishers make decisions is important for improving management of fisheries. there is debate about the extent to which small-scale fishers follow an ideal free distribution (ifd) - distributing their fishing effort efficiently according to resource availability rather than being influenced by social factors or personal preference. using detailed data from 1800 fisher catches and from semi-structured interviews with over 700 fishers at lake alaotra, the largest inland fishery in m ...201726924876
marine protected areas and children's dietary diversity in the philippines.fish living around the coral reefs in the philippines provide livelihoods for more than a million local fishers and are an important source of protein for coastal communities. however, this rich resource is at risk from myriad threats, which consequently threaten human livelihoods, nutrition, and health. in this paper, we examine the degree to which marine protected areas (mpas), which aim to conserve marine biodiversity, are associated with improved nutritional outcomes in children under age 5. ...201726924869
anti-gq1b antibody syndrome presenting as acute isolated bilateral ophthalmoplegia: report on two patients and review of the literature.miller fisher syndrome (mfs) is an acute polyradiculoneuritis regarded as an uncommon clinical variant of guillain-barré syndrome (gbs). mfs is characterized by the acute onset of the clinical triad of ophthalmoplegia, cereballar ataxia and areflexia. atypical forms of mfs presenting as isolated ophthalmoplegia without ataxia have been rarely described, mostly in adults.201626924168
patient use of complementary and alternative medicines in an outpatient pediatric neurology clinic.this article describes the use of complementary and alternative medicines in an outpatient pediatric neurology clinic, and assesses family attitudes toward the efficacy of complementary and alternative medicines versus prescription medications. complementary and alternative medicine is an important element of the modern health care landscape. there is limited information about whether, and to what extent, families perceive its utility in childhood neurological disorders.201626923752
comparison of hiv incidence estimated in clinical trial and observational cohort settings in a high risk fishing population in uganda: implications for sample size estimates.clinical trial participants may differ from the source population due to the demands of trial participation and self-selection, inadvertent selection of a lower-risk group, or both. we investigated the hiv risk status of volunteers in a simulated vaccine efficacy trial (sivet) nested within a prospective observational cohort of fisher folks in south western uganda.201626923456
customized platelet-rich plasma with transforming growth factor β1 neutralization antibody to reduce fibrosis in skeletal muscle.the formation of fibrous tissue during the healing of skeletal muscle injuries leads to incomplete recovery of the injured muscle. platelet-rich-plasma (prp) contains beneficial growth factors for skeletal muscle repair; however, it also contains deleterious cytokines and growth factors, such as tgf-β1, that can cause fibrosis and inhibit optimal muscle healing.201626923362
antitumoral effect of sunitinib-eluting beads in the rabbit vx2 tumor model.purpose to measure plasmatic sunitinib concentration (psc) and intratumoral sunitinib concentration (itsc) after transcatheter arterial chemoembolization (tace) with two different sizes of sunitinib-eluting beads (sebs) in rabbits with vx2 hepatic allografts and to investigate treatment effects on vascular endothelial growth factor receptor type 2 (vegfr2) phosphorylation, tumor volume, and histopathologic changes. materials and methods the protocol was approved by the french ethics committee fo ...201626919561
homogeneous t1 hyperintense renal lesions with smooth borders: is contrast-enhanced mr imaging needed?purpose to retrospectively determine if homogeneous high t1 signal intensity (si) masses with smooth borders on unenhanced magnetic resonance (mr) images can be characterized as benign. materials and methods institutional review board approval was obtained for this hipaa-compliant retrospective study, with waiver of informed consent. mr images in 84 patients with hemorrhagic or proteinaceous cysts and 50 patients with renal cell carcinoma (rcc) were evaluated. sixty-three cysts and 49 rccs under ...201626919441
combined bleaching technique using low and high hydrogen peroxide in-office bleaching gel.the aim of this study was to evaluate the efficacy, color stability, risk, and intensity of tooth sensitivity (ts) of combined bleaching techniques performed with 20% or 35% hydrogen peroxide for an in-office protocol.201626919081
lip cancer: a clinicopathological study and treatment outcomes in a 25-year experience.there are few clinical studies focusing on treatment outcomes of lip cancer. this study investigated the clinicopathologic variables of a large sample of patients with lip squamous cell carcinoma (lscc) treated in a reference head and neck cancer center for the past 25 years and analyzed the influence of these variables on treatment outcomes.201626917204
efficacy of and preference for reinforcement and response cost in token economies.researchers have shown that both differential reinforcement and response cost within token economies are similarly effective for changing the behavior of individuals in a group context (e.g., donaldson, deleon, fisher, & kahng, 2014; iwata & bailey, 1974). in addition, these researchers have empirically evaluated preference for these procedures. however, few previous studies have evaluated the individual effects of these procedures both in group contexts and in the absence of peers. therefore, w ...201626916640
diastolic dysfunction in liver cirrhosis: prognostic predictor in liver transplantation?patients with liver cirrhosis may develop cirrhotic cardiomyopathy (cc), characterized by blunted contractile responsiveness to stress, diastolic dysfunction (dd), and electrophysiological abnormalities. it may adversely affect the long-term prognosis of these patients.201626915857
dermoscopy, a useful tool for general practitioners in melanoma screening: a nationwide survey.dermoscopy improves diagnostic accuracy in melanoma, as shown by several meta-analyses. although it is used by general practitioners (gps) in australia, canada and italy, no published data on this topic are available in france.201626914613
secondary alveolar bone grafting (cleftsis) 2007-2010.objective to determine whether alveolar bone graft outcomes for unilateral and bilateral cleft lip and palate patients have continued to improve since the reorganization of cleft services in scotland in 2000. design retrospective analysis of postoperative anterior occlusal radiographs. patients and participants eighty-one of 106 patients who were eligible for alveolar bone grafting between 2007 and 2010 had suitable postoperative radiographs available. interventions twenty-seven percent of the p ...201626914161
correlation of pregnancy outcome with quadruple screening test at second trimester.abnormal levels of the markers afp, hcg, and ue3 could be useful in predicting adverse pregnancy outcomes. this study was designed to determine the correlation between second trimester maternal serum markers and adverse pregnancy outcome (apo).201526913244
pathogens trigger top-down climate forcing on ecosystem dynamics.evaluating the effects of climate variation on ecosystems is of paramount importance for our ability to forecast and mitigate the consequences of global change. however, the ways in which complex food webs respond to climate variations remain poorly understood. here, we use long-term time series to investigate the effects of temperature variation on the intraguild-predation (igp) system of windermere (uk), a lake where pike (esox lucius, top predator) feed on small-sized perch (perca fluviatilis ...201626910776
comparing five statistical methods of differential methylation identification using bisulfite sequencing data.we are presenting a comprehensive comparative analysis of five differential methylation (dm) identification methods: methylkit, bsmooth, biseq, hmm-dm, and hmm-fisher, which are developed for bisulfite sequencing (bs) data. we summarize the features of these methods from several analytical aspects and compare their performances using both simulated and real bs datasets. our comparison results are summarized below. first, parameter settings may largely affect the accuracy of dm identification. di ...201626910753
mutation in braf and other members of the mapk pathway in papillary thyroid carcinoma in the pediatric population.papillary thyroid carcinoma (ptc) is an uncommon tumor in the pediatric population. a limited number of studies have examined genetic mutations affecting the mitogen-activated protein kinase (mapk) pathway in the pediatric population.201626910217
marine protected area and the spatial distribution of the gill net fishery in copacabana, rio de janeiro, rj, brazil.this study characterizes the gill net fishery at colônia de pescadores z13 (cpz13), in copacabana, rio de janeiro, and its relationship with the marine protected area 'monumento natural do arquipélago das ilhas cagarras - mona cagarras', describing the fleet and fishing gears, identifying fishing spots, species and their associations by gillnet type. from june 2012 to may 2013, every tuesday to sunday, gill net landings were monitored and fishers interviewed regarding their catch. small boats (d ...201626909618
sex speeds adaptation by altering the dynamics of molecular evolution.sex and recombination are pervasive throughout nature despite their substantial costs. understanding the evolutionary forces that maintain these phenomena is a central challenge in biology. one longstanding hypothesis argues that sex is beneficial because recombination speeds adaptation. theory has proposed several distinct population genetic mechanisms that could underlie this advantage. for example, sex can promote the fixation of beneficial mutations either by alleviating interference competi ...201626909573
tumor volume is a better predictor of post-operative wound complications compared to tumor size in soft tissue sarcomas of the proximal lower extremity.wide local excision with or without radiation therapy (rt) and chemotherapy is widely accepted as appropriate management for soft tissue sarcomas (sts) of the extremity. although survival and local control rates are comparable to amputation, post-operative wound complications (wc) following limb salvage can result in significant morbidity for the patient. certain risk factors such as location, pre-operative rt, and age have been shown to increase the risk of wcs. somewhat surprisingly, size has ...201626909140
clinical evaluation of post-operative analgesia comparing suprascapular nerve block and interscalene brachial plexus block in patients undergoing shoulder arthroscopic surgery.shoulder arthroscopic surgeries have a high incidence of severe post-operative pain significant enough to interfere with recovery and rehabilitation. a regional anaesthetic technique combined with general anaesthesia reduces intra-operative requirements of anaesthesia and provides a better post-operative pain relief. as the commonly employed technique of interscalene brachial plexus block (isb) is associated with potential serious complications, suprascapular nerve block (ssb) can be used as a s ...201726908974
hepcidin as a biomarker of impaired renal function in rat models for chronic allograft nephropathy.background to explore the use of hepcidin as a marker of impaired renal function in a rat model for chronic allograft nephropathy (can). material and methods twenty-four models were developed and 20 models were included in this study, using fisher (f344) rats (donors) and lewis rats (recipients). renal function tests were performed preoperatively and postoperatively. hepcidin, interleukin-6 (il-6), and erythropoietin levels in serum and urine were measured by enzyme-linked immunosorbent assay (e ...201626907911
fmr1 cgg repeats: reference levels and race-ethnic variation in women with normal fertility (study of women's health across the nation).fmr1 premutation carriers (55-199 cgg repeats), and potentially women with high normal (35-44) or low normal (<28) cgg repeats, are at risk of premature ovarian aging. the scarcity of population data on cgg repeats <45 cgg, and variation in race-ethnicity, makes it difficult to determine true associations. dna was analyzed for fmr1 cgg repeat lengths from 803 women (386 caucasians, 219 african americans, 102 japanese, and 96 chinese) from the us-based study of women's health across the nation (s ...201626905421
increased survival of patients with end-stage hepatocellular carcinoma due to intake of oncoxin®, a dietary supplement.treatment and management of patients with end-stage hepatocellular carcinoma (hcc) represents a formidable challenge to contemporary branches of medical sciences. the study presented here was conducted to assess the utility of nutrient supplement, if any, for management of patients with end-stage hcc.201626905163
comparing zero ischemia laparoscopic radio frequency ablation assisted tumor enucleation and laparoscopic partial nephrectomy for clinical t1a renal tumor: a randomized clinical trial.we evaluated the functional outcome, safety and efficacy of zero ischemia laparoscopic radio frequency ablation assisted tumor enucleation compared with conventional laparoscopic partial nephrectomy.201626905020
presentation of gender dysphoria: a perspective from eastern india.there is paucity of scientific data from india on gender identity disorders (gids) or gender dysphoria (gd).201726904482
expression of lymphatic markers in the adult rat spinal cord.under physiological conditions, lymphatic vessels are thought to be absent from the central nervous system (cns), although they are widely distributed within the rest of the body. recent work in the eye, i.e., another organ regarded as alymphatic, revealed numerous cells expressing lymphatic markers. as the latter can be involved in the response to pathological conditions, we addressed the presence of cells expressing lymphatic markers within the spinal cord by immunohistochemistry. spinal cord ...201626903808
comparison between intravenous dexmedetomidine and local lignocaine infiltration to attenuate the haemodynamic response to skull pin head holder application during craniotomy.skull pin application is intensely painful and can be accompanied by detrimental haemodynamic changes. we compared intravenous (iv) dexmedetomidine with local infiltration of lignocaine at pin application sites to attenuate haemodynamic changes associated with pin application.201526903671
factors predicting poor outcome in a surgically managed series of multiple intracranial aneurysms.multiple factors are known to influence outcomes in single-aneurysm subarachnoid hemorrhage, such as hunt and hess (h&h) grade, hypertension, etc. we sought to assess the influence of individual risk factors on outcome in surgically managed patients with multiple intracranial aneurysm.201626902780
detection of 3-methylmethcathinone and its metabolites 3-methylephedrine and 3-methylnorephedrine in pubic hair samples by liquid chromatography-high resolution/high accuracy orbitrap mass spectrometry.hair testing is considered to be one of the most efficient tool to investigate drug-related histories, particularly when the period of use needs to be tested back to many days or even months before sampling. high-resolution mass spectrometry represents today one of the most specific and sensitive analytical techniques to detect psychoactive substances in hair samples following single or multiple drug exposures. in this study pubic hair testing, by means of liquid chromatography-high resolution/h ...201626901638
data mining framework for identification of myocardial infarction stages in ultrasound: a hybrid feature extraction paradigm (part 2).early expansion of infarcted zone after acute myocardial infarction (ami) has serious short and long-term consequences and contributes to increased mortality. thus, identification of moderate and severe phases of ami before leading to other catastrophic post-mi medical condition is most important for aggressive treatment and management. advanced image processing techniques together with robust classifier using two-dimensional (2d) echocardiograms may aid for automated classification of the exten ...201626897481
clinical features of subarachnoid hemorrhage in patients with positive cancer history.advances in cancer treatment have dramatically increased long-term survivors. prolonged survival increases comorbidity risk, but there is a paucity of studies on how cancer history alters clinical outcomes from subsequent diseases. this study aims to investigate whether positive cancer history influences clinical outcome following subarachnoid hemorrhage (sah). we retrospectively reviewed consecutive sah patients admitted between january 2008 and march 2014. medical histories, known sah risk fac ...201626897015
getting past the blame game: convergence and divergence in perceived threats to salmon resources among anglers and indigenous fishers in canada's lower fraser river.this article examines threat perception as a potential dimension of inter-group conflict over salmon fisheries in canada's fraser river watershed. environmental changes and the entry of new user groups are putting pressure on both the resource and regulators, as well as threatening to exacerbate conflicts, notably between first nation (indigenous) fishers and non-indigenous recreational anglers. while resource conflicts are often superficially conceptualized as cases of competing interests, we b ...201626897007
genomic characterization of renal cell carcinoma with sarcomatoid dedifferentiation pinpoints recurrent genomic alterations.the genomic features underpinning renal cell carcinoma with sarcomatoid dedifferentiation (srcc) are not well understood, and at present, there are no specific or effective therapies for srcc.201626895810
chemical tools of octopus maya during crab predation are also active on conspecifics.octopus maya is a major socio-economic resource from the yucatán peninsula in mexico. in this study we report for the first time the chemical composition of the saliva of o. maya and its effect on natural prey, i.e. the blue crab (callinectes sapidus), the crown conch snail (melongena corona bispinosa), as well as conspecifics. salivary posterior glands were collected from octopus caught by local fishers and extracted with water; this extract paralyzed and predigested crabs when it was injected ...201626895025
expression of pten and β-catenin and their relationship with clinicopathological and prognostic factors in endometrioid type endometrial cancer.the aim of this study was to investigate rates of expression of pten (phosphatase and tensin homolog deleted on chromosome 10) and β-catenin and their relationship with clinicopathological and prognostic factors in endometrioid type endometrial cancer (ec).201626894937
a hospital based study regarding awareness of association between glycosylated haemoglobin and severity of diabetic retinopathy in type 2 diabetic individuals.diabetic retinopathy is one of the most common microvascular complications seen in diabetic patients after a long term of uncontrolled glycaemic status as assessed by glycosylated haemoglobin a (hba1c). hence awareness of glycaemic control is necessary to prevent vision threatening complications.201626894100
singer k, fisher b. studies on abnormal hemoglobins, vi: electrophoretic demonstration of type s (sickle cell) hemoglobin in erythrocytes incapable of showing the sickle cell phenomenon. blood. 1953;8(3):270-275. 201626893392
unilateral fetal renal abnormalities: are they really isolated?our objective was to describe the association between unilateral fetal renal abnormalities and other major anomalies that were not apparent in the second trimester.201626892819
comparison of 3 intranasal mists for anesthetizing maxillary teeth in adults: a randomized, double-masked, multicenter phase 3 clinical trial.this double-masked, parallel-design, clinical trial assessed whether a combination nasal spray (k305; 3% tetracaine hydrochloride and 0.05% oxymetazoline hydrochloride) compared with a tetracaine-only spray and a placebo spray would be safer and superior in producing local anesthesia sufficient to complete a direct restorative procedure in maxillary nonmolar teeth.201626892312
molecular evidence of helicobacter pylori infection in prostate tumors.to determine whether helicobacter pylori (h. pylori) is detectable in both benign prostatic hyperplasia (bph) and prostate cancer (pca). epidemiological studies have shown significant associations between infective chronic prostatitis and prostatic carcinoma. many bacteria have been found in the prostate of patients with chronic prostatitis, bph, and pca.201526889133
subradiographic foot and ankle fractures and bone contusions detected by mri in elite ice hockey players.in ice hockey players, serious bone injuries in the foot and ankle, especially those attributed to impact from the moving puck, may be radiographically occult and underrecognized.201626888876
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