Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| rapid intradermal delivery of liquid formulations using a hollow microstructured array. | the purpose of this work is to demonstrate rapid intradermal delivery of up to 1.5 ml of formulation using a hollow microneedle delivery device designed for self-application. | 2011 | 20582455 |
| familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies. | a manageable and reproducible large animal model of human-like coronary atherosclerosis is lacking but highly needed for translational research in percutaneous coronary interventions and imaging. farm pigs with familial hypercholesterolaemia develop advanced atherosclerosis in two to three years but then weigh >200 kg making them impractical and costly. we aimed at down-sizing this pig and accelerating coronary plaque development to make the model more useful and affordable. | 2010 | 20562079 |
| hypoxia-inducible factor 1-alpha release after intracoronary versus intramyocardial stem cell therapy in myocardial infarction. | we have investigated the effect of stem cell delivery on the release of hypoxia-inducible factor 1 alpha (hif-1alpha) in peripheral circulation and myocardium in experimental myocardial ischemia. closed-chest, reperfused myocardial infarction (mi) was created in domestic pigs. porcine mesenchymal stem cells (mscs) were cultured and delivered (9.8 +/- 1.2 x 10(6)) either percutaneously noga-guided transendocardially (group im) or intracoronary (group ic) 22 +/- 4 days post-mi. pigs without msc de ... | 2010 | 20560024 |
| carbon dioxide-enhanced ct-guided placement of aortic stent-grafts: feasibility in an animal model. | to test the feasibility of carbon dioxide (co(2))-enhanced computed tomography (ct)-guided placement of infrarenal abdominal aortic stent-grafts in an animal model. | 2010 | 20557172 |
| phylogenetic analysis of classical swine fever virus isolates from peru. | classical swine fever (csf) is considered to be endemic in peru with outbreaks reported to the world organization for animal health as recently as 2008 and 2009. nevertheless, little is known regarding the genetic subgroup(s) of csf virus that are circulating in peru or their relationship to recent csf viruses that have been isolated from neighbouring south american countries or other parts of the world. in this study, we molecularly characterize csf viruses that were isolated from domestic pigs ... | 2010 | 20545910 |
| 1.5:1 meshed alloderm bolsters for stapled rectal anastomoses does not provide any advantage in anastomotic strength in a porcine model. | the most feared complication of colorectal anastomoses is leaks resulting in severe morbidity. the concept of staple-line reinforcement is a growing area of interest. in this study, the authors evaluated the feasibility and effect of using 1.5:1 meshed alloderm to bolster end-to-end stapled rectal anastomoses in a porcine model. | 2011 | 20542954 |
| classical swine fever virus in south-eastern europe--retrospective analysis of the disease situation and molecular epidemiology. | classical swine fever (csf) is among the most important diseases of domestic pigs and causes great socio-economic losses. therefore, control of csf is given high priority within the european union, including financial support of concerted control actions in candidate and in potential candidate countries. unfortunately, from some of these countries information on the csf situation and related data is very limited. this study was undertaken to gather all available information on the domestic pig p ... | 2010 | 20541876 |
| cutaneous challenge with chemical warfare agents in the skh-1 hairless mouse (ii): effects of some currently used skin decontaminants (rsdl and fuller's earth) against liquid sulphur mustard and vx exposure. | using the hairless mouse screening model presented in the companion paper(1) the aim of this study was to assess two skin decontaminating systems: fuller's earth (fe) and reactive skin decontamination lotion (rsdl) against two extremely toxic chemical warfare agents that represent a special percutaneous hazard, sulphur mustard (sm) and o-ethyl-s-(2[di-isopropylamino]ethyl)methyl-phosphonothioate (vx). five minutes after being exposed on the back to either 2 µl of neat sulphur mustard or 50 µg.kg ... | 2011 | 20534641 |
| a new surgical trainer (bopt) improves skill transfer for anastomotic techniques in gastrointestinal surgery into the operating room: a prospective randomized trial. | a multifunctional skill trainer (berlin operation trainer, bopt) allows realistic training of conventional gastrointestinal (gi) surgical techniques. the aim of this prospective randomized study was to evaluate the training success and the potential for transfer of anastomotic techniques in gi surgery into the operating room using the bopt. | 2010 | 20533037 |
| gastric lymphatic basin dissection for sentinel node biopsy using hybrid natural orifice transluminal endoscopic surgery (notes). | the aim of the present study was to describe a method of gastric lymphatic basin dissection for sentinel node biopsy using natural orifice transluminal endoscopic surgery with laparoscopic assistance (hybrid notes) in a porcine model. lymph node dissection was performed in three healthy female domestic farm pigs (each around 40 kg) between october, 2007, and december, 2007. the pigs were administered a general anesthetic and laparoscopy-guided transvaginal colpotomy was performed. a two-channel ... | 2010 | 20528682 |
| a long arm for ultrasound: a combined robotic focused ultrasound setup for magnetic resonance-guided focused ultrasound surgery. | focused ultrasound surgery (fus) is a highly precise noninvasive procedure to ablate pathogenic tissue. fus therapy is often combined with magnetic resonance (mr) imaging as mr imaging offers excellent target identification and allows for continuous monitoring of fus induced temperature changes. as the dimensions of the ultrasound (us) focus are typically much smaller than the targeted volume, multiple sonications and focus repositioning are interleaved to scan the focus over the target volume. ... | 2010 | 20527572 |
| laser-induced thermotherapy (litt)--evaluation of a miniaturised applicator and implementation in a 1.0-t high-field open mri applying a porcine liver model. | to evaluate the feasibility and safety of a novel litt applicator for thermal ablation of liver malignancies in 1.0-t high-field open mri. | 2010 | 20526885 |
| iron chelation for amelioration of liver ischemia-reperfusion injury. | liver resections are frequently associated with significant ischemia-reperfusion (i-r) injury of the liver remnant. the aim of this study was to investigate whether deferoxamine (dfo) can ameliorate i-r injury during major hepatectomies performed under vascular exclusion of the liver in a porcine model. twelve female domestic pigs were divided into control (n = 6) and dfo treatment (n = 6) groups and subjected to 150 min. liver ischemia followed by 70% hepatectomy and 24 hours reperfusion. pigs ... | 2010 | 20524816 |
| chitosan arrests bleeding in major hepatic injuries with clotting dysfunction: an in vivo experimental study in a model of hepatic injury in the presence of moderate systemic heparinisation. | the purpose of this study was to explore the effectiveness of two chitosan formulations, omni-stat® granules and celox gauze®, in a model of major hepatic injury in the presence of clotting dysfunction. | 2010 | 20522310 |
| avian influenza vaccination in chickens and pigs with replication-competent adenovirus-free human recombinant adenovirus 5. | protective immunity to avian influenza (ai) virus can be elicited in chickens by in ovo or intramuscular vaccination with replication-competent adenovirus (rca)-free human recombinant adenovirus serotype 5 (ad5) encoding ai virus h5 (adtw68.h5) or h7 (adcn94.h7) hemagglutinins. we evaluated bivalent in ovo vaccination with adtw68.h5 and adcn94.h7 and determined that vaccinated chickens developed robust hemagglutination inhibition (hi) antibody levels to both h5 and h7 ai strains. additionally, w ... | 2010 | 20521636 |
| rethinking cull boar transport. | 2010 | 20514259 | |
| molecular and serological survey of hepatitis e virus infection among domestic pigs in inner mongolia, china. | to evaluate the prevalence and characteristics of swine hepatitis e virus (hev) infection in inner mongolia, china, serum samples obtained from 356 2- to 4-month-old pigs on 14 farms in inner mongolia were tested for the presence of anti-hev antibodies and hev rna. overall, 186 pigs (52%) tested positive for anti-hev antibodies, while 30 pigs (8%) had detectable hev rna levels. the 30 hev isolates recovered from the viremic pigs were phylogenetically classified into genotype 4 and differed from ... | 2010 | 20512514 |
| cell distribution after intracoronary bone marrow stem cell delivery in damaged and undamaged myocardium: implications for clinical trials. | abstract : introduction : early randomized clinical trials of autologous bone marrow cardiac stem cell therapy have reported contradictory results highlighting the need for a better evaluation of protocol designs. this study was designed to quantify and compare whole body and heart cell distribution after intracoronary or peripheral intravenous injection of autologous bone marrow mononuclear cells in a porcine acute myocardial infarction model with late reperfusion. methods : myocardial infarcti ... | 2010 | 20504285 |
| an animal model for sinus floor elevation with great elevation heights. macroscopic, microscopic, radiological and micro-ct analysis: ex vivo. | different animal models are used for research and training concerning sinus floor elevation. however, there is little information regarding an animal model for elevation heights of approximately 10 mm. the aim of this study was to explore the anatomical aspects of the maxillary sinus of adult pigs and to investigate the suitability of this animal as a model for sinus floor elevation training and research with great elevation heights. | 2010 | 20497438 |
| [hepatitis e--a new zoonotic disease in germany?]. | hepatitis e virus (hev) is the most frequent pathogen of a fecal-oral transmitted hepatitis in humans in many developing countries. it is endemic in the middle east, in india, in southeast asia, central asia as well as in central and south america. it can be predominantly found in young adults. the mortality rate comes up to 2% whereas in pregnant women death rate can reach about 25%. until a few years ago, acute hepatitis e was thought to be rare in industrialized countries: most cases were fou ... | 2010 | 20496825 |
| dietary consistency and the midline sutures in growing pigs. | the purpose of this study was to investigate the effects of reduced masticatory function on midline suture growth and morphology in growing pigs. | 2010 | 20477970 |
| mitochondrial dna diversity in wild boar from the primorsky krai region (east russia). | we have studied the cytochrome b gene and control region dna variability in 14 wild boars from the primorsky region, in the far east corner of russia. variability was low (π = 0.00248 overall) compared with the usual estimates in these loci, indicating that this is a rather closed population. seven haplotypes were found, and one was identical to a chinese wild boar. phylogeographically, the sequences clustered among several asian clades, primarily chinese domestic pigs and japanese and chinese w ... | 2011 | 20477807 |
| analysis of the non-recombining y chromosome defines polymorphisms in domestic pig breeds: ancestral bases identified by comparative sequencing. | sequences from 20 amplicons representing nine different loci and 11369bp from the short arm of the pig y chromosome were compared using pools of dna from different european and chinese breeds. a total of 33 polymorphic sites were identified, including five indels and 28 single nucleotide polymorphisms (snps). three high frequency snps within the coding regions of sry were further analysed across 889 males representing 25 european and 25 asian breeds or lines, plus a european line of meishan. two ... | 2010 | 20477804 |
| divergence time estimates of east asian and european pigs based on multiple near complete mitochondrial dna sequences. | the time since the divergence of european and east asian domestic pigs and wild boars has been estimated in several phylogenetic analyses, generally based on partial mitochondrial sequences or on a small number of complete mtdna sequences. in the present study, we obtained a refined estimate of this divergence time based on a set of 32 near-complete mtdna sequences from wild and domestic pigs of european and asian types, including 14 new and 18 previously published sequences. a weighted average ... | 2011 | 20477794 |
| epidemiological survey of trichinellosis in wild boar (sus scrofa) and fox (vulpes vulpes) in a french insular region, corsica. | the mediterranean island of corsica was considered trichinella-free until 2004, when t. britovi larvae were discovered in domestic pigs at meat inspection. one red fox was also found infected the same year and in the same area than the infected pigs. this last finding highlighted the presence of trichinellosis in corsican wildlife. a trichinella survey was thus performed in wild boar (sus scrofa) and fox (vulpes vulpes), the two large wild species present on the island, to determine prevalence o ... | 2010 | 20471753 |
| familiarity breeds contempt: kangaroos persistently avoid areas with experimentally deployed dingo scents. | whether or not animals habituate to repeated exposure to predator scents may depend upon whether there are predators associated with the cues. understanding the contexts of habituation is theoretically important and has profound implication for the application of predator-based herbivore deterrents. we repeatedly exposed a mixed mob of macropod marsupials to olfactory scents (urine, feces) from a sympatric predator (canis lupus dingo), along with a control (water). if these predator cues were al ... | 2010 | 20463952 |
| early atherosclerosis aggravates the effect of renal artery stenosis on the swine kidney. | atherosclerotic renal artery stenosis (aras) is increasingly identified in patients with end-stage renal disease. renal function in aras patients deteriorates more frequently than in nonatherosclerotic renal artery stenosis (ras). this study was designed to test the hypothesis that atherosclerosis modifies the relationship between single-kidney hemodynamics and function and the severity of stenosis. the degree of unilateral ras in domestic pigs (4 normal, 26 ras, and 22 aras) was correlated with ... | 2010 | 20462971 |
| brucella suis infection in domestic pigs and wild boar in croatia. | between the years 2000 and 2004, 93,107 sera from 1,997 pig herds in 11 regions of croatia were tested for the presence of antibodies against brucellosis. positive results were observed in 67 herds from seven regions (mean individual prevalence: approximately 1%; herd prevalence: 3.4%). the herds from all but two of the infected farms were reared outdoors and thus almost certainly came into contact with wildlife. from 2003 to 2004, 424 sera, which were randomly collected from hunted wild boar (s ... | 2009 | 20462164 |
| detection of porcine circovirus in rodents - short communication. | porcine circoviruses (pcv) are present worldwide, infecting domestic pigs and wild boars alike. studies under laboratory conditions indicated that pcv can be taken up by mice and the virus can replicate in these animals. the possible role of rodents in maintaining and transmitting pcv2 infection in the field has not been investigated yet. the present study reports the detection of pcv2, the pathogenic form of the virus, in mice and rats. a number of rodents, such as mice, rats and voles, were co ... | 2010 | 20460225 |
| experimental infection of pigs with border disease virus isolated from pyrenean chamois (rupicapra pyrenaica). | between 2001 and 2007, several outbreaks of disease associated with border disease virus (bdv) infection were reported in the central pyrenees (northeast spain) and were associated with a major reduction in chamois (rupicapra pyrenaica) populations. at the same time, wild boars (sus scrofa) from the same area were found to be seropositive to this pestivirus, without showing clinical signs. the present study examines the susceptibility of domestic swine and the course of the infection with a bdv ... | 2010 | 20453208 |
| neuroprotective effects of the inhalational anesthetics isoflurane and xenon after cardiac arrest in pigs. | neurologic outcome after cardiopulmonary resuscitation from cardiac arrest carries a poor prognosis and treatment options to ameliorate brain damage are limited. | 2008 | 20449916 |
| intra-arrest rapid head cooling improves postresuscitation myocardial function in comparison with delayed postresuscitation surface cooling. | to compare resuscitation outcomes and myocardial function among intra-arrest head cooling, delayed surface cooling, and uncooled controls. | 2008 | 20449907 |
| a comparison between head cooling begun during cardiopulmonary resuscitation and surface cooling after resuscitation in a pig model of cardiac arrest. | employing transnasal head-cooling in a pig model of prolonged ventricular fibrillation, we compared the effects of 4 hrs of head-cooling started during cardiopulmonary resuscitation with those of 8 hrs of surface-cooling started at 2 hrs after resuscitation on 96-hr survival and neurologic outcomes. | 2008 | 20449906 |
| the amplitude spectrum area correctly predicts improved resuscitation and facilitated defibrillation with head cooling. | when systemic hypothermia was maintained before inducing cardiac arrest, the likelihood of successful defibrillation and meaningful survival was increased. when hypothermia is induced during cardiopulmonary resuscitation, mortality is also improved. with the introduction of the amplitude spectrum area as a predictor of the success of electrical defibrillation, we investigated the effect of preferential head cooling initiated coincident with cardiopulmonary resuscitation on amplitude spectrum are ... | 2008 | 20449903 |
| pure "cable-tie partial nephrectomy": a porcine model. | the standard surgical procedure for polar renal tumors is nephron-sparing surgery, currently performed laparoscopically in most cases. this technically challenging surgery involves clamping of the hilar vessels and warm kidney ischemia. this study tested the feasibility of performing polar nephrectomy using a cable tie without hilar clamping or any other hemostatic procedure. | 2010 | 20445994 |
| variation of aujeszky's disease viruses in wild swine in usa. | in the united states of america, aujeszky's disease (pseudorabies) has been eradicated from all domestic swine. some re-emergence of infection occurred as vaccine use diminished. sporadic outbreaks have also occurred because of the reservoir of infection in feral swine that have spread across the southern two-thirds of the country and hawaii. in order to be able to understand the origins of re-emerging virus, sequence analysis of variable genes in pseudorabies virus (prv) has been used to differ ... | 2010 | 20444559 |
| a study of alternative splicing in the pig. | abstract: | 2010 | 20444244 |
| diffuse reflectance spectroscopy for optical soft tissue differentiation as remote feedback control for tissue-specific laser surgery. | laser surgery does not provide haptic feedback for operating layer-by-layer and thereby preserving vulnerable anatomical structures like nerve tissue or blood vessels. diffuse reflectance spectra can facilitate remote optical tissue differentiation. it is the aim of the study to use this technique on soft tissue samples, to set a technological basis for a remote optical feedback system for tissue-specific laser surgery. | 2010 | 20432281 |
| endoscopic mucosal resection using a grasp-and-snare technique. | endoscopic mucosal resection (emr) is a minimally invasive method for en bloc removal of superficial gastrointestinal lesions. the aim of this study was to evaluate the feasibility of a novel grasp-and-snare emr technique. | 2010 | 20432205 |
| correlation of right ventricular dysfunction parameters and pulmonary vascular obstruction score in acute pulmonary embolism in a porcine model. | this paper aims to non-invasively determine right ventricular dysfunction parameters (rvdp) in acute pulmonary embolism (ape) and to correlate these parameters with a computed tomography (ct)-based pulmonary artery obstruction score (os). in seven domestic pigs, magnetic resonance imaging (mri) was performed before (n = 7) and after (n = 5) ape was induced. analysis of relative changes in right ventricular stroke volume (rvsv%), output (rvo%), end-systolic (rvesv%), end-diastolic volume (rvedv%) ... | 2010 | 20428913 |
| temporal distribution of ten calyptrate dipteran species of medicolegal importance in rio de janeiro, brazil. | brazilian studies involving entomological succession patterns in carcasses have been used to describe the necrophagous entomofauna of a determined municipality or region with forensic objectives. following the same objectives, an ecological study with 10 calyptrate dipterans was carried out during the winter of 2007 and the summer of 2008 in the metropolitan region of the municipality of rio de janeiro. the aim of this study was to describe several aspects of the phenology of these species in th ... | 2010 | 20428680 |
| influence of the lung mechanical ventilation with injurious parameters on 7-ketocholesterol synthesis in sus scrofa. | the aim of work was to investigate changes of 7-ketocholesterol synthesis in alveolar macrophages in the dynamic of lung mechanical ventilation with injurious parameters. the goal of in vitro part of work was to observe influence of 7-ketocholesterol on inos and mip1 beta production in bronchoalveolar lavage fluid (balf) cells. we used 17 healthy domestic pigs randomly assigned into two treatment groups: group i with mechanical ventilation with physiological parameters; group || underwent injuri ... | 2010 | 20423610 |
| light microscopic, electron microscopic, and immunohistochemical comparison of bama minipig (sus scrofa domestica) and human skin. | here we sought to evaluate the possibility of using chinese bama miniature pig skin as a suitable animal model for human skin. morphologic features of the skin of bama miniature pigs resemble those of human skin, including skin layer thickness, development of a superficial vascular system, structure of the dermal-epidermal interface, and extracellular matrix. the characteristics and densities of langerhans cells, fibroblasts, vascular endothelial cells, and mast cells were similar between bama p ... | 2010 | 20412690 |
| patterns of east asian pig domestication, migration, and turnover revealed by modern and ancient dna. | the establishment of agricultural economies based upon domestic animals began independently in many parts of the world and led to both increases in human population size and the migration of people carrying domestic plants and animals. the precise circumstances of the earliest phases of these events remain mysterious given their antiquity and the fact that subsequent waves of migrants have often replaced the first. through the use of more than 1,500 modern (including 151 previously uncharacteriz ... | 2010 | 20404179 |
| pathomorphological changes after radiofrequency ablation in the liver. | radiofrequency ablation (rfa) has become a widespread treatment option for liver carcinoma. there is limited knowledge regarding the macroscopic and histomorphological changes of induced lesions. twelve domestic pigs underwent rfa using a starburst xl device with ablation diameter of 3 cm. one animal died within 24 h, two animals were killed after 2 weeks, and nine after 4 weeks. their livers were used for macroscopic and histological investigation. six human liver resection specimens after prev ... | 2010 | 20403040 |
| comparative animal study on hard tissue integration and bone formation of different nobel biocare implants. | dental implantation aims at optimal and long-term hard tissue integration. beside primary stability, loading time and other factors, e.g. the surface of the endosteal part of the implant, is a matter of special importance. in this animal trial, hard tissue integration of two different implant types was studied using radiological, histological and histomorphometric analysis. two different implants with an oxidized surface (tiunite; nobel biocare ab, goteborg, sweden, nobelreplace tapered groovy 4 ... | 2009 | 20400804 |
| development and validation of a sensitive hplc method for the quantification of hi-6 in guinea pig plasma and evaluated in domestic swine. | a rapid and small volume assay to quantify hi-6 in plasma was developed to further the development and licensing of an intravenous formulation of hi-6. the objective of this method was to develop a sensitive and rapid assay that clearly resolved hi-6 and an internal standard in saline and plasma matrices. a fully validated method using ion-pair hplc and 2-pam as the internal standard fulfilled these requirements. small plasma samples of 35 microl were extracted using acidification, filtration an ... | 2010 | 20395179 |
| a novel approach for reinforcing the pancreatic remnant in laparoscopic distal pancreatectomy: an experimental study on a porcine model. | the major postoperative complication after open and laparoscopic distal pancreatectomy is pancreatic fistula. different operative techniques have been tested to minimize this unpleasant complication. we evaluated a new technique for pancreatic stump reinforcement with synthetic glue after laparoscopic distal pancreatectomy. ten female domestic pigs were divided into 2 groups; in group a (n=5), the pancreas was transected using an endogia stapler, whereas in group b (n=5), the pancreas was transe ... | 2010 | 20393319 |
| heterogeneous memory in restitution of action potential duration in pig ventricles. | restitution of action potential duration and memory importantly affect electrical stability in ventricles. studies have reported heterogeneous restitution among different regions of the ventricles. however, existence of heterogeneity in memory is not as well investigated. | 2010 | 20378123 |
| studying phenotypic evolution in domestic animals: a walk in the footsteps of charles darwin. | charles darwin used domesticated plants and animals as proof of principle for his theory on phenotypic evolution by means of natural selection. inspired by darwin's work, we developed an intercross between the wild boar and domestic pigs to study the genetic basis for phenotypic changes during domestication. the difference in coat color is controlled by two major loci. dominant white color is due to two consecutive mutations in the kit gene: a 450-kb duplication and a splice mutation. black spot ... | 2010 | 20375320 |
| calcium-dependent signalling is essential during collateral growth in the pig hind limb-ischemia model. | we investigated the effect of pharmacological activation of the ca(2+)-channel transient receptor potential cation channel, subfamily v, member 4 (trpv4) on collateral growth in a pig hind limb-ischemia model thereby identifying subcellular mechanisms. domestic pigs received femoral artery ligature and were randomly assigned to one of the following groups (each n=6): (1) 4alpha-phorbol 12,13-didecanoate (4alphapdd) treatment; (2) treatment with an arterio-venous shunt (av-shunt) distal to the oc ... | 2010 | 20363225 |
| glucagon-like peptide-1 (glp-1) attenuates post-resuscitation myocardial microcirculatory dysfunction. | post-resuscitation syndrome leads to death in approximately 2 out of every 3 successfully resuscitated victims, and myocardial microcirculatory dysfunction is a major component of this syndrome. the aim of this study was to determine if glucagon-like peptide-1 (glp-1) improves post-resuscitation myocardial microcirculatory function. | 2010 | 20347207 |
| qualitative and quantitative distribution of pcv2 in wild boars and domestic pigs in germany. | porcine circovirus 2 (pcv2), the causative agent of postweaning multisystemic wasting syndrome (pmws), has been detected in north american and european wild boars at prevalences arguing for high circulation rates among populations. systematic data on the qualitative distribution of pcv2 infections and on pcvd (pcv2 diseases) in wild boars are rare, however, and quantitative data about viral loads are missing. to be able to judge the pcv2/pcvd situation in wild boars, evaluation of the nationwide ... | 2010 | 20346600 |
| the optimal phasic relationship between synchronized shock and mechanical chest compressions. | pauses for shock delivery in chest compressions are detrimental to the success of resuscitation and may be eliminated with the use of mechanical chest compressors. however, the optimal phasic relationship between mechanical chest compression and defibrillation is still unknown. we therefore undertook a study to assess the effects of timing of defibrillation in the mechanical chest compression cycle on the defibrillation threshold (dft) using a porcine model of cardiac arrest. | 2010 | 20346567 |
| [radiofrequency ablation as a palliative therapy option in ent tumors: in vivo and in vitro testing]. | high frequency thermotherapy (hftt) is an established palliative therapy for hepatic malignancies. an in vivo and in vitro trial examined the preconditions for the application of hftt with liquid-cooled wet electrodes for minimally invasive palliation of head and neck tumors. | 2010 | 20336271 |
| a gel-free approach in vascular smooth muscle cell proteome: perspectives for a better insight into activation. | abstract: | 2010 | 20334645 |
| [haemorrhagic septicaemia in a pig caused by extraintestinal pathogenic escherichia coli (expec) as a differential diagnosis in classical swine fever--case report and review of the literature]. | domestic pig herds in some regions of germany are permanently threatened by classical swine fever. in the case of suspicion, a series of infectious and non infectious causes has to be excluded. the present paper describes a case of escherichia coli septicaemia, with clinical and pathological symptoms that could not be differentiated from european or african swine fever. the e. coli strain could not be classified by standard serotyping. virulence factors common for etec (enterotoxic e. coli) or e ... | 2010 | 20329644 |
| treatment with bioartificial liver improves lung injury in a swine model of partial hepatectomy and ischemia/reperfusion. | hepatic ischemia/reperfusion injury can lead to remote lung injury by inducing oxidative stress and inflammation. this study aims to investigate whether support of liver function with a bioartificial liver can attenuate remote lung injury after extended hepatectomy. | 2010 | 20306437 |
| patterns of gene expression in swine macrophages infected with classical swine fever virus detected by microarray. | infection of domestic swine with highly virulent, classical swine fever virus (csfv) strain brescia, causes lethal disease in all infected animals. however, the molecular mechanisms involved in modulating the host cellular processes and evasion of the immune response have not been clearly established. to gain insight into, the early host response to csfv, we analyzed the pattern of gene expression in infected swine macrophages, using custom designed swine microarrays. macrophages, the target cel ... | 2010 | 20302897 |
| comparison between locking and non-locking plates for fixation of metacarpal fractures in an animal model. | the use of locking plates increases the primary load to failure, thereby reducing the rate of implant-related failure. the good clinical and biomechanical results of locking plates in long bones might be applicable to treatment of metacarpal fractures. the purpose of this study was to determine strength and stiffness of locking plates in a metacarpal fracture model with mono- and bicortical screw fixation in comparison to non-locking plate mono- and bicortical screw fixation, with both types of ... | 2010 | 20299161 |
| mutations in the ns1 c-terminal tail do not enhance replication or virulence of the 2009 pandemic h1n1 influenza a virus. | the 'classical' swine h1n1 influenza a virus lineage was established after the devastating 1918 human pandemic virus entered domestic pig herds. a descendent of this lineage recently re-emerged in humans as the 2009 pandemic h1n1 virus. adaptation in pigs has led to several changes in the multifunctional viral ns1 protein as compared with the parental 1918 virus, most notably a k217e substitution that abolishes binding to host crk/crkl signalling adapters, and an 11 aa c-terminal truncation. usi ... | 2010 | 20237225 |
| mammalian limb loading and chondral modeling during ontogeny. | the adaptive growth response of cartilage, or chondral modeling, can result in changes in joint and limb proportions during ontogeny and ultimately contribute to the adult form. despite hamrick's (1999) reevaluation of the mechanisms of chondral modeling, the process of chondral modeling remains poorly studied in animal models. here, we characterize the macro- and microanatomical responses of the femoral growth plate, articular cartilage, and bone in 15 juvenile sus scrofa domestica subjected to ... | 2010 | 20235322 |
| ischemia as a possible effect of increased intra-abdominal pressure on central nervous system cytokines, lactate and perfusion pressures. | the aims of our study were to evaluate the impact of increased intra-abdominal pressure (iap) on central nervous system (cns) cytokines (interleukin 6 and tumor necrosis factor), lactate and perfusion pressures, testing the hypothesis that intra-abdominal hypertension (iah) may possibly lead to cns ischemia. | 2010 | 20230612 |
| deciphering modifications in swine cardiac troponin i by top-down high-resolution tandem mass spectrometry. | cardiac troponin i (ctni) is an important regulatory protein in cardiac muscle, and its modification represents a key mechanism in the regulation of cardiac muscle contraction and relaxation. ctni is often referred to as the "gold-standard" serum biomarker for diagnosing patients with acute cardiac injury since it is unique to the heart and released into the circulation following necrotic death of cardiac tissue. the swine (sus scrofa) heart model is extremely valuable for cardiovascular researc ... | 2010 | 20223681 |
| impact of tube current in the quantitative assessment of acute reperfused myocardial infarction with 64-slice delayed-enhancement ct: a porcine model. | this study evaluated the impact of tube current (mas) in delayed-enhancement computed tomography (ct) imaging for assessing acute reperfused myocardial infarction in a porcine model. | 2010 | 20221710 |
| evaluation of a hemostatic sponge (tachosil) for sealing of the renal collecting system in a porcine laparoscopic partial nephrectomy survival model. | the objective of this study was to evaluate the efficacy of tachosil (nycomed uk, oxford, buckinghamshire, uk), a hemostatic sponge, to seal major collecting system injuries (in addition to providing an adjunct to hemostasis) after partial nephrectomy in a porcine chronic survival model. | 2010 | 20218894 |
| spatial distribution and risk factors of brucellosis in iberian wild ungulates. | the role of wildlife as a brucellosis reservoir for humans and domestic livestock remains to be properly established. the aim of this work was to determine the aetiology, apparent prevalence, spatial distribution and risk factors for brucellosis transmission in several iberian wild ungulates. | 2010 | 20205703 |
| tame affairs: domesticated transposase and domestic pigs. | 2010 | 20203696 | |
| blood meal analysis to identify reservoir hosts for amblyomma americanum ticks. | efforts to identify wildlife reservoirs for tick-borne pathogens are frequently limited by poor understanding of tick-host interactions and potentially transient infectivity of hosts under natural conditions. to identify reservoir hosts for lone star tick (amblyomma americanum)-associated pathogens, we used a novel technology. in field-collected ticks, we used pcr to amplify a portion of the 18s rrna gene in remnant blood meal dna. reverse line blot hybridization with host-specific probes was th ... | 2010 | 20202418 |
| the effect of posterior distraction on vertebral growth in immature pigs: an experimental simulation of growing rod technique. | experimental study. | 2010 | 20195208 |
| seroprevalence and risk factors associated with toxoplasma gondii infection in pig farms from catalonia, north-eastern spain. | seroprevalence and associated risk factors for toxoplasma gondii infection in pigs were analyzed in 1202 sera samples, including sows and pigs of three, seven, 11, 15 and 20 weeks of age, from 23 farms in catalonia, north-eastern spain. antibodies were tested by the modified agglutination test (mat) at titers > or =1:25. antibodies to t. gondii were found in 228 samples (19.0%; 95% ci: 16.8-21.2). the individual prevalence in animals higher than 7 weeks of age was 22.8% (174/762; 95% ci: 16.6-29 ... | 2010 | 20189210 |
| comparison of articular cartilage repair by autologous chondrocytes with and without in vitro cultivation. | autologous chondrocyte implantation usually requires in vitro cell expansion before implantation. we compared the efficacy of cartilage regeneration by in vitro-expanded chondrocytes at high density and freshly harvested chondrocytes at low density. | 2010 | 20187869 |
| rapid and selective enzymatic debridement of porcine comb burns with bromelain-derived debrase: acute-phase preservation of noninjured tissue and zone of stasis. | deep burns are associated with the formation of an eschar, which delays healing and increases the risk of infection. surgical debridement of the eschar is, at present, the fastest means to achieve an eschar-free bed, but the process can not differentiate between the viable tissue and the eschar and follow the minute irregularities of the interface between the two. we evaluated the efficacy and selectivity of a novel enzymatic bromelain-based debriding agent, debrase gel dressing (debrase), in a ... | 2010 | 20182376 |
| interplay between ovine bone marrow stromal cell antigen 2/tetherin and endogenous retroviruses. | endogenous betaretroviruses (enjsrvs) of sheep are expressed abundantly in the female reproductive tract and play a crucial role in conceptus development and placental morphogenesis. interestingly, the colonization of the sheep genome by enjsrvs is likely still ongoing. during early pregnancy, enjsrv expression correlates with the production of tau interferon (ifnt), a type i ifn, by the developing conceptus. ifnt is the pregnancy recognition signal in ruminants and possesses potent antiviral ac ... | 2010 | 20181686 |
| peritoneal inflammation in pigs is associated with early mitochondrial dysfunction in liver and kidney. | the objective of this study was to investigate early effects of peritoneal inflammation on the mitochondrial function in the vital organs, liver and kidney, and their relation to inflammatory and oxidative stress mediators. the study was performed on 14 domestic pigs. peritoneal inflammation was induced in anesthetized pigs after a midline laparotomy by autologous feces. fluid resuscitation maintained a map above 60 mmhg. animals were sacrificed 12 h later, and tissue samples were obtained to de ... | 2010 | 20180005 |
| a trucut biopsy needle for bipolar radiofrequency ablation of needle tract: a proof-of-concept experiment. | to develop a trucut biopsy needle featuring two electrodes that allow for bipolar radiofrequency (rf) coagulation of the puncture tract. | 2010 | 20179938 |
| artificial selection of the melanocortin receptor 1 gene in chinese domestic pigs during domestication. | black coat colour is common in chinese indigenous domestic pigs, but not among their wild ancestors, and it is thus presumed to be a 'domestication trait.' to determine whether artificial interference contributes to morphological diversification, we examined nucleotide variation from 157 chinese domestic pigs and 40 wild boars in the melanocortin receptor 1 (mc1r) gene, which has a key role in the coat pigmentation of sus scrofa. compared with a pseudogene gpip, our results showed that the joint ... | 2010 | 20179735 |
| reduction of odorants in swine manure by carbohydrate and bacterial amendments. | malodors from pig manure storage pits are a problem lacking a cost-efficient solution particularly for small pig (sus domestica) farms. the objective of this study was to reduce emissions of noxious odorants by changing the conditions in the pig manure to favor an altered microbial community. sugars (maltose, lactose, and saccharose), carbohydrate-rich waste (maltose syrup and wheat flour), and bacterial amendments (lactobacillus plantarum and l. amylophilus) were tested for their effect on manu ... | 2010 | 20176840 |
| human perception of vocalizations of domestic piglets and modulation by experience with domestic pigs (sus scrofa). | interspecific communication between humans and pets is possible through vocal cues. we studied how humans with differing experience with domestic pigs (sus scrofa) interpret pig vocalizations. forty-eight ethologists studying pigs, 31 pig-caretakers and 54 naive students evaluated the emotional intensity and valence (negative/positive) of recordings from two negative (castration, isolation) and two positive (reunion with the sow, postsuckling) contexts. they also identified the context in which ... | 2010 | 20175599 |
| a novel double-endoloop technique for natural orifice transluminal endoscopic surgery gastric access site closure. | effective and safe access site closure is critical for clinical application of natural orifice transluminal endoscopic surgery. | 2010 | 20170912 |
| [the influence of hypothermia therapy on enzymology and pathology of lung after cardiac arrest]. | to study the effect of hypothermia on pro-inflammatory mediators in serum, the enzymology and pathology of lung tissue. | 2010 | 20170611 |
| nanofiber micro-dispersed oxidized cellulose as a carrier for topical antimicrobials: first experience. | micro-dispersed oxidized cellulose, already used for hemostasis, might be helpful for introduction of an antimicrobial drug. | 2010 | 20163259 |
| refinement of pig retroperfusion technique: global retroperfusion with ligation of the azygos connection preserves hemodynamic function in an acute infarction model in pigs (sus scrofa domestica). | in ischemic hearts, venous retroperfusion is a potential myocardial revascularization strategy. this study aimed to refine the technical and functional aspects of a pig model of acute myocardial infarction and retroperfusion with respect to the azygos connection. global retroperfusion after ligation of the ramus interventricularis paraconalis (equivalent to the left anterior descending artery in humans) was performed in 16 landrace pigs (sus scrofa domestica). coronary sinus perfusion was perfor ... | 2010 | 20158947 |
| increased sinusoidal flow is not the primary stimulus to liver regeneration. | hemodynamic changes in the liver remnant following partial hepatectomy (phx) have been suggested to be a primary stimulus in triggering liver regeneration. we hypothesized that it is the increased sinusoidal flow per se and hence the shear-stress stimulus on the endothelial surface within the liver remnant which is the main stimulus to regeneration. in order to test this hypothesis we wanted to increase the sinusoidal flow without performing a concomitant liver resection. accordingly, we constru ... | 2010 | 20148099 |
| the influence of penetrative trauma on the rate of decomposition. | an understanding of the factors affecting decomposition is important for the accurate estimation of postmortem interval. an experimental study on the influence of penetrating trauma on decomposition rate was carried out using the domestic pig, sus scrofa. the results of this study were: (i) diptera were preferentially attracted to and oviposited at natural orifices. trauma sites were not preferentially selected for oviposition; (ii) no differences between trauma and non-trauma groups were found ... | 2010 | 20141561 |
| heterogeneity in spike protein genes of porcine epidemic diarrhea viruses isolated in korea. | porcine epidemic diarrhea virus (pedv) has plagued the domestic swine industry in korea causing significant economic impacts on pig production nationwide. in the present study, we determined the complete nucleotide sequences of the spike (s) glycoprotein genes of seven korean pedv isolates. the entire s genes of all isolates were found to be nine nucleotides longer in length than other pedv reference strains. this size difference was due to the combined presence of notable 15 bp insertion and 6 ... | 2010 | 20132850 |
| discriminating the effect of accelerated compression from accelerated decompression during high-impulse cpr in a porcine model of cardiac arrest. | piston based mechanical chest compression devices deliver compressions and decompressions in an accelerated pattern, resulting in superior haemodynamics compared to manual compression in animal studies. the present animal study compares haemodynamics during two different hybrid compression patterns to a standard compression pattern resembling that of modern mechanical chest compression devices. | 2010 | 20122780 |
| functional and comparative evaluation of flexible monopolar endoscopic scissors. | the continued success of natural orifice translumenal endoscopic procedures requires reliable, accurate tissue dissection and suture cutting. this study aimed to evaluate a flexible endoscopic scissors prototype. | 2010 | 20108151 |
| developmental ability of miniature pig embryos cloned with mesenchymal stem cells. | the present study compared the developmental ability of miniature pig embryos cloned with fetal fibroblasts (ffs), bone marrow-derived mesenchymal stem cells (mscs) and differentiated (osteocytes, adipocytes and chondrocytes) mscs. mscs were isolated from an approximately 1-month-old female miniature pig (t-type, pwg micro-pig((r)), pwg genetics korea). mscs were differentiated into osteocytes, adipocytes and chondrocytes under controlled conditions and characterized by cell surface antigen prof ... | 2010 | 20103985 |
| spatial and temporal expression of spermadhesin genes in reproductive tracts of male and female pigs and ejaculated sperm. | spermadhesins, a novel protein family identified in the reproductive tract of ungulates, have important roles in reproduction. in this study, the expression of pig (sus domesticus) spermadhesion genes in seminal vesicles, prostate, and bulbourethral glands from birth to sexual maturity and the spatial expression in adult male and female genital tracts and ejaculated sperm of meishan pigs were evaluated by reverse transcription-polymerase chain reaction (rt-pcr). in general, all spermadhesin gene ... | 2010 | 20102779 |
| ex vivo skin infection model. | over the past decade, the emergence of bacterial strains resistant to conventional antibiotics has necessitated the discovery and development of new antimicrobial therapies. this chapter describes a skin infection model that is based on the use of excised skin derived from the domestic pig. the model conditions mimic the environment of human skin and efficiently support the growth of clinically relevant bacterial and fungal species, thus making it useful for evaluating the activity of antimicrob ... | 2010 | 20094875 |
| tissue distribution of polybrominated diphenyl ethers (pbdes) in captive domestic pigs, sus scrofa, from a village near an electronic waste recycling site in south china. | the dominant part of pbdes residue in pig tissues was bde-47 accounted for 48.2% approximately 66.9%, followed by bde-99 from 15.9% to 24.2%. when the data were on lipid weight basis, the summation operatorpbdes concentrations in tissues of individual pig showed the same order of liver > muscle, intestine > fat. principal component analysis and pbde congener mean concentration ratios of muscle versus liver (m/l), fat versus liver (f/l) and intestine versus liver (i/l) showed the higher accumulat ... | 2010 | 20091151 |
| survival and neurological outcomes after nasopharyngeal cooling or peripheral vein cold saline infusion initiated during cardiopulmonary resuscitation in a porcine model of prolonged cardiac arrest. | we have previously demonstrated that nasopharyngeal cooling initiated during cardiopulmonary resuscitation improves the success of resuscitation. in this study, we compared the effects of nasopharyngeal cooling with cold saline infusion initiated during cardiopulmonary resuscitation on resuscitation outcome in a porcine model of prolonged cardiac arrest. we hypothesized that nasopharyngeal cooling initiated during cardiopulmonary resuscitation would yield better resuscitation outcome when compar ... | 2010 | 20081534 |
| preliminary studies into the characterization of chemical markers of decomposition for geoforensics. | in this paper, we report the results of our preliminary studies into chemical characterization of the fluids produced during decomposition in the absence of a soil matrix. pig (sus domestica) carcasses were used to model the human decomposition process in two separate locations, western australia (perth) and canada (oshawa). analysis involved simple dilution and filtration of the decomposition fluids followed by gas chromatography-mass spectrometry. several previously unreported compounds were d ... | 2010 | 20070470 |
| comparing the demonstration of freedom from trichinella infection of domestic pigs by traditional and risk-based surveillance. | traditionally, the routine artificial digestion test is applied to assess the presence of trichinella larvae in pigs. however, this diagnostic method has a low sensitivity compared to serological tests. the results from artificial digestion tests in switzerland were evaluated over a time period of 15 years to determine by when freedom from infection based on these data could be confirmed. freedom was defined as a 95% probability that the prevalence of infection was below 0.0001%. freedom was dem ... | 2010 | 20067658 |
| serological, pathological and polymerase chain reaction studies on mycoplasma hyopneumoniae infection in the wild boar. | there are evidences that wild boar and domestic pig populations share the vulnerability to certain pathogens and, in consequence, the risk of pathogen transmission. based on serological evidences, it is known that mycoplasma hyopneumoniae (mhyo) is able to infect the wild boar. however, if this infection causes lesions and disease in this species is still unknown. the objectives of the present study were to assess the seroprevalence to mhyo, as well as the rates of detection of mhyo (by nested p ... | 2010 | 20060659 |
| effects of oxygen tension and follicle cells on maturation and fertilization of porcine oocytes during in vitro culture in follicular fluid. | the objective was to investigate the effects of oxygen tension and follicle cells (fcs) during in vitro maturation of porcine oocytes in only porcine (sus scrofa domesticus) follicular fluid (pff), using static and non-static (rotating) culture systems, on the nuclear maturation and subsequent in vitro fertilization of the oocytes. in the first experiment, cumulus-oocyte complexes (cocs) were matured for 48 h in pff supplemented with (+) or without (-) fcs (5.2x10(6) cells/ml), using the static ... | 2010 | 20060577 |
| seasonal effect on sperm messenger rna profile of domestic swine (sus scrofa). | seasonal infertility is a well-known problem in the modern swine (sus scrofa) industry. the molecular mechanisms responsible for thermal effects on spermatogenesis are, however, just beginning to be elucidated. the existence of specific messenger rna (mrna) remnants contained within freshly ejaculated sperm has been identified in several species. investigators have obtained differential rna profiles of infertile men compared with fertile individuals; however, there are limited to the probes, whi ... | 2010 | 20056359 |
| molecular characterisation of african swine fever viruses from nigeria (2003-2006) recovers multiple virus variants and reaffirms cvr epidemiological utility. | samples collected from wild and domestic suids in nigeria, over a 3-year period (2003-2006), were evaluated for african swine fever (asf) virus genome presence by targeting three discrete genome regions, namely the 478-bp c-terminal p72 gene region advocated for genotype assignment, a 780-bp region spanning the 5'-ends of the pb125r and pb646l (p72) genes and the hypervariable central variable region (cvr) encoded within the 9rl orf (pb602l). asf virus (asfv) presence was confirmed in 23 of the ... | 2010 | 20052526 |
| development of an ultra-high-pressure liquid chromatography-tandem mass spectrometry multi-residue sulfonamide method and its application to water, manure slurry, and soils from swine rearing facilities. | an analytical method was developed using ultra-high-pressure liquid chromatography-triple quadrupole-tandem mass spectrometry (uhplc-tq-ms/ms) to simultaneously analyze 14 sulfonamides (sa) in 6 min. despite the rapidity of the assay the system was properly re-equilibrated in this time. no carryover was observed even after high analyte concentrations. the instrumental detection limit based on signal-to-noise ratio (s/n)>3, was below 1 pg/microl (5 pg on column) for all sas except sulfachloropyri ... | 2010 | 20047751 |