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imipenem-associated encephalopathy: alert to physicians. 201020339671
impact of hospital-wide infection rate, invasive procedures use and antimicrobial consumption on bacterial resistance inside an intensive care unit.we performed a 30-month ecological study to determine the impact of hospital-wide antibiotic consumption, invasive procedure use and hospital-acquired infections (hais) on antibiotic resistance in an intensive care unit (icu). microbiological isolates from icu patients with established diagnosis of hospital infection were monitored throughout the study. overall hospital consumption per 100 patient-days of piperacillin-tazobactam, fluoroquinolones and cephalosporins increased from 1.9 to 2.3 defi ...201020338669
severe mediastinal infection with abscess formation after endobronchial ultrasound-guided transbrochial needle aspiration.endobronchial, ultrasound-guided, transbronchial needle aspiration has recently been introduced as an alternative to mediastinoscopy for lymph node staging of lung cancer and the diagnosis of respiratory diseases. this procedure is less invasive and more cost-effective, and multiple large studies have reported no associated complications. in this case, an individual presented with descending mediastinitis after having this minimally invasive procedure for mediastinal lymphadenopathy.201020338352
temperature and ph affect the production of bacterial biofilm.the effect of different cultivation temperatures (30 and 37 degrees c) and ph of the media (5.5, 7.5, 8.5) on the biofilm production was compared in pseudomonas aeruginosa, klebsiella pneumoniae, and vibrio cholerae non-o1 and o1 using the crystal-violet test for estimation of quantitative production of the biofilm. decrease (46.4-98.4 %) in the biofilm production was observed at 37 degrees c in 8 of the tested strains (p. aeruginosa three strains, k pneumoniae two, v. cholerae non-o1 two, and v ...201020336508
isolation of some pathogenic bacteria from the great spruce bark beetle, dendroctonus micans and its specific predator, rhizophagus grandis.some bacteria were isolated from dendroctonus micans and its specific predator, rhizophagus grandis. six bacteria from d. micans were identified as bacillus pumilus, enterobacter intermedius, citrobacter freundii, cellulomonas flavigena, microbacterium liquefaciens and enterobacter amnigenus, three bacteria from r. grandis as klebsiella pneumoniae, pantoea agglomerans and serratia grimesii, on the basis of fatty acid methyl ester analysis and carbon utilization profile by using microbial identif ...201020336502
antibacterial activity of medicinal plants against pathogens causing complicated urinary tract infections.seventeen indian folklore medicinal plants were investigated to evaluate antibacterial activity of aqueous, ethanol and acetone extracts against 66 multidrug resistant isolates of major urinary tract pathogens (escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa and enterococcus faecalis) by disc diffusion method. ethanol extract of zingiber officinale and punica granatum showed strong antibacterial activity against escherichia coli. ethanol extracts of terminalia chebula and ocimum ...200920336211
[diversity changes of the microbial communities and bla(ctx-m) genes in urban river sediments treated with cefotaxime].to explore the diversity changes of microbial communities and bla(ctx-m) in an urban river sediment community with cefotaxime treatment.201020335110
outbreak of carbapenem-resistant klebsiella pneumoniae in puerto rico associated with a novel carbapenemase variant.carbapenem-resistant klebsiella pneumoniae (crkp) is resistant to almost all antimicrobial agents, and crkp infections are associated with substantial morbidity and mortality.201020334553
multidrug resistance among gram-negative pathogens that caused healthcare-associated infections reported to the national healthcare safety network, 2006-2008.we evaluated isolates of klebsiella pneumoniae, pseudomonas aeruginosa, and acinetobacter baumannii that were reported to the national healthcare safety network from january 2006 through december 2008 to determine the proportion that represented multidrug-resistant phenotypes. the pooled mean percentage of resistance varied by the definition used; however, multidrug resistance was relatively common and widespread.201020334552
essential oil from the underground parts of laserpitium zernyi: potential source of alpha-bisabolol and its antimicrobial activity.the composition and antimicrobial activity of the essential oil from the underground parts (roots and rhizomes) of laserpitium zernyi hayek (apiaceae) were investigated. the pale blue essential oil, obtained by hydrodistillation, was analyzed by gc and gc-ms. forty-three compounds were identified (94.3% of total oil). the main constituent, beside alpha-pinene (31.6%) was alpha-bisabolol (30.9%), so this oil may be a novel potential natural source of this sesquiterpene alcohol. the antimicrobial ...201020334149
isolation and characterization of indole acetic acid (iaa) producing klebsiella pneumoniae strains from rhizosphere of wheat (triticum aestivum) and their effect on plant growth.the present study was undertaken for isolation of klebsiella strains from rhizosphere of wheat (t. aestivum), screening and characterization of these strains for in vitro indole acetic acid (iaa) production and studying the effect of these strains on plant growth under gnotobiotic conditions. nine strains of klebsiella were isolated from rhizosphere of wheat (var. lokwan) and identified as k. pneumoniae by 16s rrna gene sequencing. six k. pneumoniae strains showed in vitro iaa production. colori ...200920329704
maggot excretions inhibit biofilm formation on biomaterials.biofilm-associated infections in trauma surgery are difficult to treat with conventional therapies. therefore, it is important to develop new treatment modalities. maggots in captured bags, which are permeable for larval excretions/secretions, aid in healing severe, infected wounds, suspect for biofilm formation. therefore we presumed maggot excretions/secretions would reduce biofilm formation.201020309656
mutant prevention concentrations of four carbapenems against gram-negative rods.we tested the propensities of four carbapenems to select for resistant escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, and acinetobacter baumannii mutants by determining the mutant prevention concentrations (mpcs) for 100 clinical strains with various ss-lactam phenotypes. among the members of the enterobacteriaceae family and a. baumannii strains, the mpc/mic ratios were mostly 2 to 4. in contrast, for p. aeruginosa the mpc/mic ratios were 4 to > or =16. the mpc/mic ratios for ...201020308376
[characterization of extended-spectrum beta-lactamases in nosocomial strains of klebsiella pneumoniae].in this study, 25 strains of k. pneumoniae, isolated from patients with nosocomial infections from august 2002 to december 2003, were examined to determine their antimicrobial susceptibility, plasmid profile, transfer capacity of resistance determinants and bla(tem), bla(shv), and bla(ctx-m) genes. nineteen nosocomial strains revealed a weakened susceptibility to third-generation cephalosporins and aztreonam, and were extended-spectrum beta-lactamases (esbls) producers. all strains presented con ...200920306716
septic shock due to klebsiella pneumoniae after medical abortion with misoprostol-only regimen.to report a case of a healthy woman who was admitted to the hospital with septic shock caused by a common uropathogen after self-administration of misoprostol for pregnancy termination.201020303487
genereviewscommon variable immune deficiency (cvid) is characterized by humoral immune deficiency with onset after age 24 months and usually in young adulthood, resulting in increased susceptibility to infections and diminished responses to protein and polysaccharide vaccines. the most common infections are sinopulmonary and include streptococcus pneumonia, hemophilis influenza, klebsiella pneumonia, and sometimes mycoplasma infections. individuals may experience meningitis or other systemic bacterial infe ...199320301476
utilization of amino acids by bacteria from the pig small intestine.this study determined the utilization of amino acids (aa) by bacteria from the lumen of the pig small intestine. digesta samples from different segments of the small intestine were inoculated into media containing 10 mmol/l each of select aa (l-lysine, l-threonine, l-arginine, l-glutamate, l-histidine, l-leucine, l-isoleucine, l-valine, l-proline, l-methionine, l-phenylalanine or l-tryptophan) and incubated for 24 h. the previous 24-h culture served as an inoculum for a subsequent 24-h subcultur ...201020300787
extended spectrum beta-lactamase detection in gram-negative bacilli of nosocomial origin.resistance to third generation cephalosporins by acquisition and expression of extended spectrum beta lactamase (esbl) enzymes among gram-negative bacilli is on a rise. the presence of esbl producing organisms significantly affects the course and outcome of an infection and poses a challenge to infection management worldwide.200920300397
fatal postoperative candida glabrata septicemia in a child with congenital heart disease.the incidence of candidemia has been reported to be high in some cardiovascular surgery units. congenital heart disease has been considered a risk factor for acquisition of candidemia. this present case is a postoperative candida glabrata in a child with congenital heart disease. a 3-year-old child, a previously diagnosed case of situs-solitus d loop situs with double outlet right ventricle, ventricular septal defect, pulmonary stenosis and large ostium secundum atrial septal defect, was admitte ...200920300391
clinical characteristics of nosocomial infections in neonatal intensive care unit in eastern china.a retrospective cohort study on nosocomial infections (ni) in the neonatal intensive care unit (nicu) was performed in the children's hospital of zhejiang university, hangzhou district, china. the most common infection site was pneumonia and bloodstream infection. low admission age, long nicu stay, and mechanical ventilation were significant risk factors for ni. klebsiella pneumoniae was the most common pathogen, followed by acinetobacter baumannii, staphylococcus epidermidi, pseudomonas aerugin ...201020297900
[not available]. 194720266267
klebsiella ozaenae infection of mink. 194720249441
in situ polytetrafluoroethylene graft bypass for primary infected aneurysm of the infrarenal abdominal aorta.reinfection is a major issue of surgical treatment for patients with infected abdominal aortic aneurysm (aaa). the present report describes outcomes after use of our procedure for treating patients with infected aneurysm of the infrarenal abdominal aorta. the procedure involved an in situ polytetrafluoroethylene (ptfe) graft bypass and omental wrapping of the graft. the procedure was used regardless of the presence of gram-stain-positive pus or tissue or the type of pathogen identified.201020238215
the udp-galp mutase catalyzed isomerization: synthesis and evaluation of 1,4-anhydro-beta-d-galactopyranose and its [2.2.2] methylene homologue.the synthesis of 1,4-anhydro-beta-d-galactopyranose (1,5-anhydro-alpha-d-galactofuranose), a proposed intermediate in the ring contraction isomerisation catalyzed by udp-galactopyranose mutase, together with its [2.2.2] bicyclic methylene homologue, synthesised as a possible competitive inhibitor or alternative substrate, are reported. neither compound was found to be an inhibitor or substrate for udp-galactopyranose mutase from klebsiella pneumoniae.201020237670
development and evaluation of oligonucleotide chip based on the 16s-23s rrna gene spacer region for detection of pathogenic microorganisms associated with sepsis.oligonucleotide chips targeting the bacterial internal transcribed spacer region (its) of the 16s-23s rrna gene, which contains genus- and species-specific regions, were developed and evaluated. forty-three sequences were designed consisting of 1 universal, 3 gram stain-specific, 9 genus-specific, and 30 species-specific probes. the specificity of the probes was confirmed using bacterial type strains including 54 of 52 species belonging to 18 genera. the performance of the probes was evaluated u ...201020237100
synthesis of 1-(4-methoxybenzyl)-3-cyclopropyl-1h-pyrazol-5-amine derivatives as antimicrobial agents.a series of novel substituted 1-(4-methoxybenzyl)-3-cyclopropyl-1h-pyrazol-5-amine benzamides 9(a-h) were synthesized to determine their antibacterial and antifungal activities as well as possible structure-activity relationships (sars) to improve therapeutic efficacy. the pyrazol-5-amine benzamides were screened for their antibacterial activity against standard strains of gram-positive (streptococcus pyogenes ncim 2608, staphylococcus aureus atcc 29737, bacillus subtilis ncim 2010) and gram-neg ...201020235748
comparison of the efficacy of rose bengal and erythrosin in photodynamic therapy against enterobacteriaceae.the aim of this study was to evaluate the effects of the photosensitizers rose bengal and erythrosin combined with a light-emitting diode (led) on enterobacteriaceae. twelve enterobacteriaceae strains isolated from the oral cavities of patients undergoing prolonged antibiotic therapy, including three escherichia coli, three enterobacter cloacae, three klebsiella oxytoca and three klebsiella pneumoniae, were studied. an enterobacteriaceae suspension (10(6) cells/ml) was prepared from each clinica ...201020232222
design, synthesis, characterization, and antibacterial activity of {5-chloro-2-[(3-substitutedphenyl-1,2,4-oxadiazol-5-yl)-methoxy]-phenyl}-(phenyl)-methanones.in the present investigation, a series of novel {5-chloro-2-[(3-(substitutedphenyl)-1,2,4-oxadiazol-5-yl)-methoxy]-phenyl}-(phenyl)-methanones (3a-i) have been synthesized from 5-(chloromethyl)-3-substitutedphenyl-1,2,4-oxadiazole (2a-i). the newly synthesized compounds were characterized by ir, nmr (1h and 13c), mass spectral and elemental analysis. the title compounds were investigated for in-vitro qualitative (zone of inhibition) and quantitative (mic) antibacterial activity by agar cup plate ...201020231043
genetic background of quinolone resistance in ctx-m-15-producing klebsiella pneumonia and escherichia coli strains in tunisia. 201020227997
bloodstream infections caused by qnr-positive enterobacteriaceae: clinical and microbiologic characteristics and outcomes.the clinical significance of plasmid-mediated quinolone resistance determinant qnr has not been well characterized. we investigated the clinical and microbiologic characteristics and outcomes of bloodstream infections (bsis) caused by qnr-positive enterobacteriaceae. we prospectively collected 351 nonduplicate consecutive blood isolates of enterobacter spp. and klebsiella pneumoniae. qnr genes were detected by polymerase chain reaction and confirmed by sequencing. the medical records of patients ...201020227228
plasmid-mediated quinolone resistance determinants qnr and aac(6')-ib-cr in escherichia coli and klebsiella spp. from norway and sweden.the prevalence of the plasmid-mediated quinolone resistance genes qnr and aac(6')-ib-cr was investigated among clinical isolates of escherichia coli and klebsiella spp. selected from 2 collections of consecutive isolates collected in 2004 to 2005 in norway (n = 2479) and sweden (n = 2980) and 1 group of extended-spectrum beta-lactamase (esbl)-producing isolates collected in 2003 in norway (n = 71). a total of 414 isolates was selected for screening based on resistance to nalidixic acid and/or re ...201020226333
in vitro activity of tigecycline against patient isolates collected during phase 3 clinical trials for diabetic foot infections.the in vitro activity of tigecycline and comparative antimicrobial agents was evaluated against 1828 primary baseline pathogens isolated from 844 patients enrolled in the phase 3 clinical trials investigating the efficacy of tigecycline in diabetic foot infection (dfi). the trials were global, enrolling patients in 30 countries. tigecycline was active against the most prevalent pathogens in dfi, including gram-positive and gram-negative isolates of both aerobic and anaerobic bacteria with 95% of ...201020226331
the function of wzy_k1 (maga), the serotype k1 polymerase gene in klebsiella pneumoniae cps gene cluster. 201020225957
increased isolation of esbl producing klebsiella pneumoniae with emergence of carbapenem resistant isolates in pakistan: report from a tertiary care hospital.to report trends of extended spectrum beta lactamase (esbl), multidrug resistant (mdr) esbl and emergence of carbapenem resistant esbl producing isolates of k. pneumoniae from pakistan.201020225774
recurrent hemolacria: a sign of scleral buckle infection.the purpose of this study was to report recurrent hemolacria, or "bloody tears," as a sign of scleral buckle (sb) infection.201020224466
bilateral scrotal abscesses caused by klebsiella pneumoniae in a newborn.the management of acute scrotal swelling can be challenging in neonatal age, with scrotal infections being great mimickers of testicular torsion. only a few unilateral cases of scrotal abscess have been previously reported, mostly caused by staphylococcus and salmonella. we describe the case of a newborn who developed bilateral scrotal abscesses caused by klebsiella pneumoniae and discuss the rarity of the case, regarding both the bilaterality and the pathogen, never reported before.201020223303
[age-related features of dysbiosis of large intestine].to compare rate of detection of stage ii-iii intestinal dysbiosis with normal and decreased quantities of bacteria from lactobacillus and bifidobacterium families in different age groups.201020222187
substrate specificity and evolutionary implications of a nifdk enzyme carrying nifb-co at its active site.the in vitro reconstitution of molybdenum nitrogenase was manipulated to generate a chimeric enzyme in which the active site iron-molybdenum cofactor (femo-co) is replaced by nifb-co. the nifdk/nifb-co enzyme was unable to reduce n(2) to nh(3), while exhibiting residual c(2)h(4) and considerable h(2) production activities. production of h(2) by nifdk/nifb-co was stimulated by n(2) and was dependent on nifh and atp hydrolysis. thus, nifdk/nifb-co is a useful tool to gain insights into the catalyt ...201020219465
intercontinental spread from israel to colombia of a kpc-3-producing klebsiella pneumoniae strain.in 2008, an increase in the prevalence of carbapenem-resistant klebsiella pneumoniae was noted in a 286-bed tertiary case hospital in colombia, where 84 patients (32 infected and 52 colonized) had positive cultures. the identified index patient came from israel for a liver transplantation. high level carbapenem resistance was observed. polymyxin b and tigecycline were the only two antibiotics that remained active. pcr-restriction fragment length polymorphism analysis and sequencing revealed blak ...201120219078
faecal carriage of extended-spectrum beta-lactamase-producing bacteria in the community.we determined the faecal carriage of extended-spectrum beta-lactamase-(esbl)-producing bacteria in the community in saudi arabia. a total of 716 faecal specimens (from 505 healthy individuals and 211 community outpatients) were screened for esbl using the double-disk synergy test and confirmed by the clinical laboratory standards institute combined disk method. we found 91 (12.7%) isolates were esbl-producers. of these, 87 (95.6%) were escherichia coli and 4 (4.4%) klebsiella pneumoniae. a simil ...200920218126
isolation of multidrug-resistant klebsiella oxytoca carrying blaimp-8, associated with oxy hyperproduction, in the intensive care unit of a community hospital in spain. 201020215129
photoantimicrobials as a potential local approach to geriatric utis.to test the efficacy of acceptable photoantimicrobial agents against bacterial pathogens implicated in complicated urinary tract infection (uti) in comparison with conventionally employed antibacterials.201020214732
antibiotic resistance trends in paediatric community-acquired first urinary tract infections in the united arab emirates.we analysed the trend of antibiotic resistance of community-acquired uropathogens over a 4-year period in a cohort of children with a first episode of culture-proven urinary tract infection presenting to the department of paediatrics at a large general secondary care hospital in the united arab emirates. comparisons were made between 2 time periods: 2003-04 versus 2005-06 for 145 children aged 2 months to 12 years of age. although some changes in resistance were observed for some antibiotics bet ...201020214157
endophthalmitis post complicated cataract surgery associated with klebsiella pneumoniae.an 82-year-old woman underwent complicated cataract surgery with subsequent endophthalmitis. she presented with a unique purulent collection with ciliary body involvement and klebsiella pneumoniae was grown on culture. klebsiella is a rare cause of endophthalmitis and ciliary body involvement has not previously been reported.200920214054
first outbreak of klebsiella pneumoniae carbapenemase (kpc)-producing k. pneumoniae in germany.we report the first outbreak of klebsiella pneumoniae carbapenemase (kpc)-producing k. pneumoniae in germany. the presence of kpc was confirmed by polymerase chain reaction (pcr). the kpc-encoding plasmid was analysed by transconjugation experiments, dna sequencing, southern blotting and isoelectric focussing. typing was performed by pulsed-field gel electrophoresis (pfge). an ertapenem-resistant k. pneumoniae with low minimum inhibitory concentrations (mic) to other cabapenems (tested by the vi ...201020213255
antimicrobial resistance in pathogens causing nosocomial infections in surgery and intensive care units of two hospitals in antananarivo, madagascar.in developing countries, knowledge of antimicrobial resistance patterns is essential to define empirical therapy.201020212337
kpc-producing extreme drug-resistant klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in south korea. 201020211897
worldwide experience with the use of doripenem against extended-spectrum-beta-lactamase-producing and ciprofloxacin-resistant enterobacteriaceae: analysis of six phase 3 clinical studies.the worldwide increase in fluoroquinolone-resistant and extended-spectrum beta-lactamase (esbl)-producing enterobacteriaceae pathogens has led to doripenem and other carbapenems assuming a greater role in the treatment of serious infections. we analyzed data from 6 phase 3 multinational doripenem clinical trials on ciprofloxacin-resistant enterobacteriaceae isolates consisting of all genera (cipre) and esbl-producing enterobacteriaceae isolates consisting of escherichia coli, klebsiella spp., an ...201020211892
treatment with fluoroquinolones or with beta-lactam-beta-lactamase inhibitor combinations is a risk factor for isolation of extended-spectrum-beta-lactamase-producing klebsiella species in hospitalized patients.antibiotic exposure exerts strong selective pressure and is an important modifiable risk factor for antibiotic resistance. we aimed to identify the role of various antibiotics as risk factors for the isolation of extended-spectrum-beta-lactamase (esbl)-producing klebsiella spp. in hospitalized patients at a tertiary-care hospital. a parallel multivariable model was created to compare two groups of cases with either nosocomially acquired esbl- or non-esbl-producing klebsiella spp. to a common con ...201020211888
contribution of outer membrane protein k36 to antimicrobial resistance and virulence in klebsiella pneumoniae.loss of outer membrane protein (omp) is commonly encountered in multidrug-resistant klebsiella pneumoniae. however, little is known about the association between omp loss and virulence. in the present study, this association was investigated in k. pneumoniae.201020211860
characterization of the nasal, sublingual, and oropharyngeal mucosa microbiota in cleft lip and palate individuals before and after surgical repair.to delineate inherent differences in the microbial milieu in cleft palate patients compared with cleft lip patients and to document changes in microbial flora before and after cleft lip and palate repair.201020210635
[present-day beta-lactame antibiotics in the treatment of urinary infections in pregnant women].a multicenter trial of the prevalence and spectrum of urinary infection agents, their resistance to beta-lactame antibiotics in pregnant women in russia was conducted in two stages. stage 1 (2001) included microbiological studies, stage 2 (2005-2006)--pharmacoepidemiological ones. most frequent uropathogens in the examinees were e. coli (62.9%) and klebsiella spp (9.7%). their most common strains were often resistant to ampicillin, amoxicillin. therefore, these drugs are often ineffective agains ...200920209863
characterization of the klebsiella aerogenes urease accessory protein ured in fusion with the maltose binding protein.assembly of the klebsiella aerogenes urease metallocenter requires four accessory proteins, ured, uree, uref, and ureg, to effectively deliver and incorporate two ni2+ ions into the nascent active site of the urease apoprotein (ureabc). each accessory protein has been purified and characterized with the exception of ured due to its insolubility when it is overproduced in recombinant cells. in this study, a translational fusion was made between the maltose binding protein (mbp) and ured, with the ...201020207756
detection of the first two klebsiella pneumoniae isolates with sequence type 258 producing kpc-2 carbapenemase in denmark. 201020206479
the analysis of multiple genome comparisons in genus escherichia and its application to the discovery of uncharacterised metabolic genes in uropathogenic escherichia coli cft073.a survey of a complete gene synteny comparison has been carried out between twenty fully sequenced strains from the genus escherichia with the aim of finding yet uncharacterised genes implicated in the metabolism of uropathogenic strains of e. coli (upec). several sets of adjacent colinear genes have been identified which are present in all four upec included in this study (cft073, f11, uti89, and 536), annotated with putative metabolic functions, but are not found in any other strains considere ...201020204180
characteristics of plasmid-mediated quinolone resistance genes in extended-spectrum cephalosporin-resistant isolates of klebsiella pneumoniae and escherichia coli in korea.quinolone resistance is frequently associated with extended-spectrum cephalosporin resistance in enterobacteriaceae.201020203489
first description of klebsiella pneumoniae clinical isolates carrying both qnra and qnrb genes in portugal.in the present study, 21 multidrug-resistant klebsiella pneumoniae isolates were recovered from patients hospitalised in the intensive care unit of hospital infante d. pedro in aveiro, portugal. fifteen isolates carried qnr genes. four strains harboured the quinolone resistance genes qnra and qnrb, both located on a large plasmid in two strains (kp4 and kp10) and on different plasmids in two strains (kp5 and kp6). these findings indicate an extremely high prevalence of qnr genes associated with ...201020202799
eleven-year study of causes of neonatal bacterial meningitis in ahvaz, iran.bacterial meningitis is a devastating infection with a high mortality rate, especially in neonates. the aim of this study was to determine the causative agents that cause bacterial meningitis in khuzestan province in the south-western region of iran.201020202151
[ventilator-associated pneumonia after cardiac surgery].ventilator-associated pneumonia (vap) is a common complication in intensive care patients. patients are most likely to be affected after abdominal and thoracic surgery.200920201343
[susceptibility of enterobacteriaceae rods to selected tetracyclines].the aim of this study was to evaluated the susceptibility of enterobacteriaceae rods to tigecycline, tetracycline and doxycycline. we analysed 121 strains belonged to species as follows: escherichia coli (40 strains), proteus mirabilis (22), enterobacter cloacae (19), klebsiellapneumoniae (18), morganella morgannii (13), serratia marcescens (4), klebsiella oxytoca (3) i proteus vulgaris (2). all strains of e. coli, k. oxytoca, s. marcescens and p. vulgaris were susceptible to tigecycline. twenty ...200920201321
outbreak of infection with klebsiella pneumoniae sequence type 258 producing klebsiella pneumoniae carbapenemase 3 in an intensive care unit in italy. 201020200298
[investigation of nosocomial infection in the neonatal intensive care unit].a perspective study was conducted to describe the epidemiologic profile of nosocomial infection in the neonatal intensive care unit (nicu).201020199716
[change of esbls-kpn and esbls-eco after antimicrobial intervention].to evaluate the change of extended spectrum beta-lactamase (esbls) producing klebsiella pneumoniae (esbls-kpn) and escherichia coli (esbls-eco) causing nosocomial infection after antimicrobial intervention.201020197617
immune responses of helicoverpa armigera to different kinds of pathogens.insects react against pathogens through innate immunity. the cotton bollworm helicoverpa armigera (h. armigera) is an important defoliator and an extremely destructive pest insect of many crops. the elucidation of the mechanism of the immune response of h. armigera to various pathogens can provide a theoretical basis for new approaches to biologically control this pest.201020196874
klebsiella pneumoniae orbital cellulitis with extensive vascular occlusions in a patient with type 2 diabetes.a 39-year-old woman visited the emergency room complaining of right eye pain and swelling over the preceding three days. the ophthalmologist's examination revealed orbital cellulitis and diabetic retinopathy in the right eye, although the patient had no prior diagnosis of diabetes. it was therefore suspected that she had diabetes and orbital cellulitis, and she was started on multiple antibiotic therapies initially. she then underwent computed tomography scans of the orbit and neck and magnetic ...201020195414
antibiotic-associated hemorrhagic colitis caused by cytotoxin-producing klebsiella oxytoca.klebsiella oxytoca was recently described as the causative organism for antibiotic-associated hemorrhagic colitis (aahc). it is currently not known if this novel gastrointestinal infection exists in children. aahc is usually preceded by antibiotic treatment with penicillins, which are frequently prescribed for pediatric patients. in contrast to colitis caused by clostridium difficile, colitis caused by k oxytoca is usually segmental and located predominantly in the right colon. patients with aah ...201020194278
management of antibiotic resistance in the intensive care unit setting.over the past few decades, an alarming increase of infections caused by antibiotic-resistant pathogens, including methicillin-resistant staphylococcus aureus, vancomycin-resistant enterococcus species, carbapenem-resistant pseudomonas aeruginosa, extended-spectrum beta-lactamase-producing escherichia coli and klebsiella spp., and multidrug-resistant acinetobacter spp., has been observed, particularly in intensive care units. for clinicians, the rising resistance rate observed in nosocomial patho ...201020192683
[study of nosocomial bacillary meningitis admitted in the clinic of infectious diseases iaşi on a 20 years period].to analyze the clinical features, etiology and evolution of nosocomial bacillary meningitis admitted to the clinic of infectious diseases iaşi between 1988 and 2007.200920191822
microwave-assisted, solvent-free and parallel synthesis of some novel substituted imidazoles of biological interest.solvent free microwave assisted synthesis of some novel substituted imidazoles of biological interest is reported. first, primary aromatic or heteryl amine was condensed with aryl or heteryl aldehydes to afford corresponding schiff's base. the schiff's base further on treatment with ammonium acetate (nh(4)oac) and isatin using silica gel as the solid support, yielded the corresponding aryl imidazoles. in this paper a comparative study between the developed microwave method and conventional metho ...201020190444
2-chloroadenosine (2-cado) treatment modulates the pro-inflammatory immune response to prevent acute lung inflammation in balb/c mice suffering from klebsiella pneumoniae b5055-induced pneumonia.acute lung inflammation (ali) is a life-threatening pathology and can develop during the course of several clinical conditions such as pneumonia, acid aspiration or sepsis. adenosine plays a significant role in controlling acute inflammation via binding to a(2a) receptors on inflammatory cells, i.e. neutrophils or macrophages. the present study was designed to evaluate the anti-inflammatory and immunomodulatory effects of 2-chloroadenosine (2-cado), alone or in combination with amoxicillin/clavu ...201020189776
in vitro activities of fosfomycin and carbapenem combinations against carbapenem non-susceptible escherichia coli and klebsiella pneumoniae. 201020189774
[chronic abdominal aortic graft infection : detection with 18f-fdg-pet/ct].a 67-year-old male patient presented with recurrent fever and septic emboli due to an aorto-duodenal fistula after previous aortobiiliac bypass grafting with suspected graft infection. imaging by ultrasound, computed tomography scan (ct) and magnetic resonance imaging (mri) could not confirm graft infection. a scan using 2-deoxy-2-fluoro-[18f]-d-glucose positron emission tomography ct (18f-fdg-pet/ct) revealed a pathological uptake. the bifurcated graft was removed und revascularization was perf ...201020186379
transmission of a klebsiella pneumoniae clone harbouring genes for ctx-m-15-like and shv-112 enzymes in a neonatal intensive care unit of a kuwaiti hospital.the spread of antibiotic-resistant bacteria has become a large problem in most countries including kuwait. this antibiotic resistance is usually due to the production of extended-spectrum beta-lactamase (esbl) enzymes such as shv, tem and ctx-m. this study reports the emergence and spread of an esbl-producing klebsiella pneumoniae clone in a neonatal intensive care unit (nicu) in a kuwaiti hospital. eight esbl-producing k. pneumoniae isolates were from blood cultures of seven neonates, and two w ...201020185547
application of real-time pcr, dgge fingerprinting, and culture-based method to evaluate the effectiveness of intrinsic bioremediation on the control of petroleum-hydrocarbon plume.real-time polymerase chain reaction (pcr), denaturing gradient gel electrophoresis (dgge), and the culture-based method were applied in the intrinsic bioremediation study at a petroleum-hydrocarbon contaminated site. the genes of phenol hydroxylase (phe), ring-hydroxylating toluene monooxygenase (rmo), naphthalene dioxygenase (nah), toluene monooxygenase (tol), toluene dioxygenase (tod), and biphenyl dioxygenase (bph4) were quantified by real-time pcr. results show that phe gene was detected in ...201020185233
[endemic intravenous fluid contamination in pediatric wards].to determine the rate of contamination of intravenous solutions and injection ports in pediatric patients.200920184097
rapidly fatal bacteremic pneumonia caused by klebsiella pneumoniae with k1 hypermucoviscosity phenotype in a previously healthy young man receiving levofloxacin treatment.fatal bacteremic klebsiella pneumoniae pneumonia is commonly encountered in alcoholic and diabetic patients. this report describes a previously healthy young man with rapidly fatal bacteremic pneumonia caused by k. pneumoniae serotype k1, complicated by septic shock and multiple organ dysfunction.200920182675
activity of ertapenem, ciprofloxacin, ceftriaxone, piperacillin-tazobactam, and ampicillin-sulbactam against 12 common clinical isolates of community-acquired bacteremia.to compare the antimicrobial activities of ertapenem, ciprofloxacin, ceftriaxone, piperacillin-tazobactam, and ampicillin-sulbactam against 12 common organisms that cause community-acquired bacteremia and to identify the most active agents for the treatment of extended-spectrum beta-lactamase (esbl)-producing escherichia coli and klebsiella pneumoniae.200920182674
microbiology and epidemiology of brain abscess and subdural empyema in a medical center: a 10-year experience.brain abscess and subdural empyema are the 2 most common forms of intracranial pyogenic infections. predisposing factors and etiological agents may change with time. this study examined the epidemiological features of these conditions.200920182670
high prevalence rate of multidrug resistance among nosocomial pathogens in the respiratory care center of a tertiary hospital.there is an increasing need for respiratory care centers (rccs) for patients who require prolonged mechanical ventilation after intensive care unit (icu) stay. nosocomial infections occur at a high rate in icus, but there have been few studies of nosocomial infections in rccs in taiwan.200920182669
clinical and bacteriological characteristics of pyogenic liver abscess in non-diabetic patients.diabetes mellitus is an important risk factor for klebsiella pneumoniae liver abscess, but many patients with pyogenic liver abscess (pla) do not have diabetes. this study was conducted to compare the clinical characteristics and prognostic factors of k. pneumoniae pla with that caused by other organisms in non-diabetic patients.200920182667
prevalence and antibiotic resistance pattern of metallo-beta-lactamase-producing pseudomonas aeruginosa from burn patients--experience of an indian tertiary care hospital.the objective of the study is to determine the prevalence of pseudomonas aeruginosa from burn patients, antibiotic resistance pattern and occurrence of acquired mbl-producing p. aeruginosa among isolates collected from burn patients. in this study, two phenotypic methods were used for the detection of mbl-producing p. aeruginosa: zone enhancement with edta-impregnated imipenem and ceftazidime discs, and modified hodge test. one hundred fifty-four isolates of p. aeruginosa were obtained from july ...201020182377
a case-control study of risk factors for urinary acquisition of klebsiella pneumoniae producing ctx-m-15 in an outbreak situation in sweden.a retrospective case-control study was initiated at uppsala university hospital in 2006 during a major outbreak caused by a klebsiella pneumoniae strain producing ctx-m-15. to identify risk factors associated with acquisition of the outbreak strain in the urinary tract, 52 case patients with a urine culture positive for the outbreak strain between 1 may and 31 december 2005 were enrolled. case patients were matched 1:2 with concurrently hospitalized control patients with significant growth of su ...201020180680
plasmid incidence, antibiotic and metal resistance among enterobacteriaceae isolated from algerian streams.enterobacteriaceae isolates from surface water were examined to assess impact of feacal and/or metal pollution on heavy metal, antibiotics resistance and plasmid incidence. a bi-modal cmi distribution was noted for cadmium and mercury. on the other hand, modal distribution was observed for pb. critical metal concentration were >8, >32, > or =4096 microg ml(-1) for mercury, cadmium and lead, respectively. high resistance to pb and low resistance to cd were remarked in stream water polluted with h ...200920180322
emergence of kpc-producing klebsiella pneumoniae in italy.abstract:201020178590
antibacterial and antioxidant activity of methanol extract of evolvulus nummularius.to evaluate the antibacterial and antioxidant activity of methanol extract of evolvulus nummularius (l) l.200920177496
synthesis and antibacterial assessment of n-[4-(4-substituted phenyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-amine.in a wide search program towards new and efficient antibacterial agents, we assessed the extent to which physicochemical properties can be exploited to promote antibacterial activity associated with a series of substituted s-triazine. the synthesized compounds (1a-12b) were subsequently screened for their in vitro antibacterial activity against three gram positive (bacillus subtilis, bacillus cereus, staphylococcus aureus) and three gram-negative microorganism (salmonella typhi, escherichia coli ...200920177467
international nosocomial infection control consortium (inicc) report, data summary for 2003-2008, issued june 2009.we report the results of the international infection control consortium (inicc) surveillance study from january 2003 through december 2008 in 173 intensive care units (icus) in latin america, asia, africa, and europe. during the 6-year study, using centers for disease control and prevention (cdc) us national healthcare safety network (nhsn; formerly the national nosocomial infection surveillance system [nnis]) definitions for device-associated health care-associated infection, we collected prosp ...201020176284
antimicrobial activity of the extracts of craniotome furcata (lamiaceae).craniotome furcata (link.) o. kuntze (lamiaceae) is used in the traditional medicine for the treatment of cuts and wounds indicating antimicrobial activity.201020176098
natural history of colonization with gram-negative multidrug-resistant organisms among hospitalized patients.to determine the anatomic sites and natural history of colonization with gram-negative multidrug-resistant organisms (mdros).201020175687
successful control of an outbreak of klebsiella pneumoniae carbapenemase-producing k. pneumoniae at a long-term acute care hospital.to determine the effect of a bundle of infection control interventions on the horizontal transmission of klebsiella pneumoniae carbapenemase (kpc)-producing k. pneumoniae during an outbreak.201020175685
[urinary pneumococcal or legionella antigen detection tests and low-spectrum antibiotic therapy for community-acquired pneumonia].we performed urinary antigen tests for pneumococcus and legionella for patients with community-acquired pneumonia (cap), to prescribe a documented antibiotic therapy. we report the efficiency of low-spectrum antibiotic treatment, illustrating the inappropriateness of bacteriological respiratory sampling.201020172672
[extended-spectrum beta-lactamases in enterobacteria other than escherichia coli and klebsiella].methods for detecting esbl-producing enterobacteriaceae begin by a correct interpretation of the susceptibility profiles, applying the usual criteria for interpretative reading of the antibiogram. appropriate confirmatory methods will be consequently chosen, based on the inhibition of the enzyme by betalactamases inhibitors, generally clavulanic acid. in case of non-ampc-producing enterobacteriaceae, at least two substrates should be used -cefotaxime or ceftriaxone and ceftazidime- to detect enz ...201020172418
sepsis and its etiology among hospitalized children less than 1 year of age with intestinal failure on parenteral nutrition.infections accompany intestinal failure (if) more commonly in children than in adults, with reported incidences of 2% to 29%. appropriate care of the central venous catheter is the most important factor preventing infections; but in addition, bacteria translocate from the dysmotile gut as a possible source of septicemia. the aim of this retrospective analysis was to investigate the rate and the epidemiologic profile of septicemia in the patient group at greatest risk, namely, children less than ...201020172274
[postoperative infection due to contaminated propofol].seven patients operated on in a period of two consecutive days in the havenziekenhuis, rotterdam, the netherlands developed symptoms of sepsis following a relatively minor procedure. one patient developed fever and hypotension a few hours after surgery, and developed thrombocytopenia and leucopenia. postoperative bleeding occurred as a result of the thrombocytopenia, necessitating further surgery. this patient developed serious multi-organ failure, and required prolonged intensive care treatment ...201020170564
sialidase-based anti-influenza virus therapy protects against secondary pneumococcal infection.das181 (fludase) is a sialidase fusion protein in clinical development as a broad-spectrum anti-influenza virus (ifv) therapeutic agent. previous reports by other investigators have raised the concern that desialylation of airway epithelium might increase susceptibility to streptococcus pneumoniae infection.201020170378
molecular characterisation of trimethoprim resistance in escherichia coli and klebsiella pneumoniae during a two year intervention on trimethoprim use.trimethoprim resistance is increasing in enterobacteriaceae. in 2004-2006 an intervention on trimethoprim use was conducted in kronoberg county, sweden, resulting in 85% reduction in trimethoprim prescriptions. we investigated the distribution of dihydrofolate reductase (dfr)-genes and integrons in escherichia coli and klebsiella pneumoniae and the effect of the intervention on this distribution.201020169085
pediatric urinary tract infections in a tertiary care center from north india.paediatric urinary tract infections (uti) are associated with high morbidity and long term complications like renal scarring, hypertension, and chronic renal failure. a cause of occult febrile illness, they often remain undiagnosed. we studied the clinical and microbiologic profile and antibiotic resistance profile of such infections in paediatric uti patients at our center.201020167982
susceptibility of carbapenemase-producing strains of klebsiella pneumoniae and escherichia coli to the direct antibacterial activity of nab739 and to the synergistic activity of nab7061 with rifampicin and clarithromycin.to determine the susceptibility of carbapenemase-producing strains of klebsiella pneumoniae and escherichia coli to the direct antibacterial activity of nab739 and to the synergistic activity of nab7061 with rifampicin and clarithromycin. nab739 and nab7061 are novel polymyxin derivatives that lack the cationic charges in the linear peptide portion of polymyxin b and have pharmacokinetic properties different from those of polymyxin b.201020167589
evaluation of the antimicrobial properties of different parts of citrus aurantifolia (lime fruit) as used locally.we investigated the potency of citrus aurantifolia (lime fruit), against pathogens, in the different forms in which this fruit plant is used locally (juice of the fruit, burnt rind of the fruit commonly known as "epa-ijebu" in the yoruba dialect) and the oil obtained from steam distillation of the fruit. the antimicrobial activity of "epa-ijebu" in different solvents was also compared. the solvents include palm-wine (a local alcoholic drink tapped from palm trees), seaman's schnapps 40% alcoholi ...200620162090
biological activities of schefflera leucantha.this study investigated various biological activities of the ethanolic extract of dried ground leaves of schefflera leucantha viguier (araliaceae). the extract possessed very low cytotoxicity to brine-shrimp with the lc(50) of 4,111.15 microg/ml; the significant antioxidant activity on dpph with the ec(50) of 71.90 microg/ml; the inhibitory activity on mushroom tyrosinase with the ic(50) of 10.53 mg/ml using the dopachrome microplate-assay. the extract of 5-20 mg/ml range in the agar dilution as ...200620162087
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