Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| host-specific induction of escherichia coli fitness genes during human urinary tract infection. | uropathogenic escherichia coli (upec) is the predominant etiological agent of uncomplicated urinary tract infection (uti), manifested by inflammation of the urinary bladder, in humans and is a major global public health concern. molecular pathogenesis of upec has been primarily examined using murine models of uti. translational research to develop novel therapeutics against this major pathogen, which is becoming increasingly antibiotic resistant, requires a thorough understanding of mechanisms i ... | 2014 | 25489107 |
| role of the streptococcus mutans crispr-cas systems in immunity and cell physiology. | crispr-cas systems provide adaptive microbial immunity against invading viruses and plasmids. the cariogenic bacterium streptococcus mutans ua159 has two crispr-cas systems: crispr1 (type ii-a) and crispr2 (type i-c) with several spacers from both crispr cassettes matching sequences of phage m102 or genomic sequences of other s. mutans. the deletion of the cas genes of crispr1 (δc1s), crispr2 (δc2e), or both crispr1+2 (δc1sc2e) or the removal of spacers 2 and 3 (δcr1sp13e) in s. mutans ua159 did ... | 2014 | 25488301 |
| role of the streptococcus mutans crispr-cas systems in immunity and cell physiology. | crispr-cas systems provide adaptive microbial immunity against invading viruses and plasmids. the cariogenic bacterium streptococcus mutans ua159 has two crispr-cas systems: crispr1 (type ii-a) and crispr2 (type i-c) with several spacers from both crispr cassettes matching sequences of phage m102 or genomic sequences of other s. mutans. the deletion of the cas genes of crispr1 (δc1s), crispr2 (δc2e), or both crispr1+2 (δc1sc2e) or the removal of spacers 2 and 3 (δcr1sp13e) in s. mutans ua159 did ... | 2014 | 25488301 |
| transcriptomic and proteomic analyses reveal key innate immune signatures in the host response to the gastrointestinal pathogen campylobacter concisus. | pathogenic species within the genus campylobacter are responsible for a considerable burden on global health. campylobacter concisus is an emergent pathogen that plays a role in acute and chronic gastrointestinal disease. despite ongoing research on campylobacter virulence mechanisms, little is known regarding the immunological profile of the host response to campylobacter infection. in this study, we describe a comprehensive global profile of innate immune responses to c. concisus infection in ... | 2014 | 25486993 |
| transcriptomic and proteomic analyses reveal key innate immune signatures in the host response to the gastrointestinal pathogen campylobacter concisus. | pathogenic species within the genus campylobacter are responsible for a considerable burden on global health. campylobacter concisus is an emergent pathogen that plays a role in acute and chronic gastrointestinal disease. despite ongoing research on campylobacter virulence mechanisms, little is known regarding the immunological profile of the host response to campylobacter infection. in this study, we describe a comprehensive global profile of innate immune responses to c. concisus infection in ... | 2014 | 25486993 |
| in silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases. | near universal administration of vaccines mandates intense pharmacovigilance for vaccine safety and a stringently low tolerance for adverse events. reports of autoimmune diseases (aid) following vaccination have been challenging to evaluate given the high rates of vaccination, background incidence of autoimmunity, and low incidence and variable times for onset of aid after vaccinations. in order to identify biologically plausible pathways to adverse autoimmune events of vaccine-related aid, we u ... | 2014 | 25486901 |
| tetracycline resistance genes in campylobacter jejuni and c. coli isolated from poultry carcasses. | campylobacter is one of the leading bacterial species causing foodborne illnesses in humans. antimicrobial agents have been extensively used for treatment of campylobacter infections; but in the recent years, both animal and human isolates of this bacterium have shown resistance to several antibiotics such as tetracycline. | 2014 | 25485062 |
| antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa. | the intestinal mucosa squares the circle by allowing efficient nutrient absorption while generating a firm barrier toward the enteric microbiota, enteropathogenic microorganisms and high luminal concentrations of potent immunostimulatory molecules. the mucus layer together with local antimicrobial and anti-inflammatory peptides significantly contribute to this ability. here we summarize the recent progress made to better understand the critical importance of this dynamic, complex and highly stru ... | 2014 | 25483327 |
| dissemination of 6s rna among bacteria. | 6s rna is a highly abundant small non-coding rna widely spread among diverse bacterial groups. by competing with dna promoters for binding to rna polymerase (rnap), the rna regulates transcription on a global scale. rnap produces small product rnas derived from 6s rna as template, which rearranges the 6s rna structure leading to dissociation of 6s rna:rnap complexes. although 6s rna has been experimentally analysed in detail for some species, such as escherichia coli and bacillus subtilis, and w ... | 2014 | 25483037 |
| identification of a lineage specific zinc responsive genomic island in mycobacterium avium ssp. paratuberculosis. | maintenance of metal homeostasis is crucial in bacterial pathogenicity as metal starvation is the most important mechanism in the nutritional immunity strategy of host cells. thus, pathogenic bacteria have evolved sensitive metal scavenging systems to overcome this particular host defence mechanism. the ruminant pathogen mycobacterium avium ssp. paratuberculosis (map) displays a unique gut tropism and causes a chronic progressive intestinal inflammation. map possesses eight conserved lineage spe ... | 2014 | 25481572 |
| significant reduction in helicobacter pylori load in humans with non-viable lactobacillus reuteri dsm17648: a pilot study. | reducing the amount of helicobacter pylori in the stomach by selective bacterial-bacterial cell interaction was sought as an effective and novel method for combating the stomach pathogen. lactobacillus reuteri dsm17648 was identified as a highly specific binding antagonist to h. pylori among more than 700 wild-type strains of lactobacillus species. applying a stringent screening procedure, the strain dsm17648 was identified as selective binder to h. pylori cells under in vivo gastric conditions. ... | 2014 | 25481036 |
| significant reduction in helicobacter pylori load in humans with non-viable lactobacillus reuteri dsm17648: a pilot study. | reducing the amount of helicobacter pylori in the stomach by selective bacterial-bacterial cell interaction was sought as an effective and novel method for combating the stomach pathogen. lactobacillus reuteri dsm17648 was identified as a highly specific binding antagonist to h. pylori among more than 700 wild-type strains of lactobacillus species. applying a stringent screening procedure, the strain dsm17648 was identified as selective binder to h. pylori cells under in vivo gastric conditions. ... | 2014 | 25481036 |
| genome-wide identification of genes necessary for biofilm formation by nosocomial pathogen stenotrophomonas maltophilia reveals that orphan response regulator fsnr is a critical modulator. | stenotrophomonas maltophilia is a gram-negative bacterial pathogen of increasing concern to human health. most clinical isolates of s. maltophilia efficiently form biofilms on biotic and abiotic surfaces, making this bacterium resistant to a number of antibiotic treatments and therefore difficult to eliminate. to date, very few studies have investigated the molecular and regulatory mechanisms responsible for s. maltophilia biofilm formation. here we constructed a random transposon insertion muta ... | 2015 | 25480754 |
| energetics of pathogenic bacteria and opportunities for drug development. | the emergence and spread of drug-resistant pathogens and our inability to develop new antimicrobials to overcome resistance has inspired scientists to consider new targets for drug development. cellular bioenergetics is an area showing promise for the development of new antimicrobials, particularly in the discovery of new anti-tuberculosis drugs where several new compounds have entered clinical trials. in this review, we have examined the bioenergetics of various bacterial pathogens, highlightin ... | 2014 | 25476763 |
| the role of the gut microbiota in the pathogenesis of antiphospholipid syndrome. | infectious triggers are associated with the induction of transient antiphospholipid antibodies. one therefore wonders if microbes that permanently colonize us play a role in the pathogenesis of antiphospholipid syndrome (aps). the microbiota represents the collection of all microorganisms colonizing humans and is necessary for normal host physiology. the microbiota, however, is a constant stress on the immune system, which is tasked with recognizing and eliminating pathogenic microbes while tole ... | 2015 | 25475595 |
| conservation analysis of the cydx protein yields insights into small protein identification and evolution. | the reliable identification of proteins containing 50 or fewer amino acids is difficult due to the limited information content in short sequences. the 37 amino acid cydx protein in escherichia coli is a member of the cytochrome bd oxidase complex, an enzyme found throughout eubacteria. to investigate the extent of cydx conservation and prevalence and evaluate different methods of small protein homologue identification, we surveyed 1095 eubacteria species for the presence of the small protein. | 2014 | 25475368 |
| antimicrobial activity of gallic acid against thermophilic campylobacter is strain specific and associated with a loss of calcium ions. | gallic acid has been suggested as a potential antimicrobial for the control of campylobacter but its effectiveness is poorly studied. the minimum inhibitory concentration (mic) and minimum bactericidal concentration (mbc) of gallic acid against campylobacter jejuni (n = 8) and campylobacter coli (n = 4) strains was determined. gallic acid inhibited the growth of five c. jejuni strains and three c. coli strains (mic: 15.63-250 μg ml(-1)). gallic acid was only bactericidal to two c. coli strains ( ... | 2015 | 25475290 |
| intraspecies competition for niches in the distal gut dictate transmission during persistent salmonella infection. | in order to be transmitted, a pathogen must first successfully colonize and multiply within a host. ecological principles can be applied to study host-pathogen interactions to predict transmission dynamics. little is known about the population biology of salmonella during persistent infection. to define salmonella enterica serovar typhimurium population structure in this context, 129svj mice were oral gavaged with a mixture of eight wild-type isogenic tagged salmonella (wits) strains. distinct s ... | 2014 | 25474319 |
| reducing campylobacter jejuni colonization of poultry via vaccination. | campylobacter jejuni is a leading bacterial cause of human gastrointestinal disease worldwide. while c. jejuni is a commensal organism in chickens, case-studies have demonstrated a link between infection with c. jejuni and the consumption of foods that have been cross-contaminated with raw or undercooked poultry. we hypothesized that vaccination of chickens with c. jejuni surface-exposed colonization proteins (secps) would reduce the ability of c. jejuni to colonize chickens, thereby reducing th ... | 2014 | 25474206 |
| sensitivity of quantitative microbial risk assessments to assumptions about exposure to multiple consumption events per day. | quantitative microbial risk assessments (qmras) of contaminated drinking water usually assume the daily intake volume is consumed once a day. however, individuals could consume water at multiple time points over 1 day, so the objective was to determine if the number of consumption events per day impacted the risk of infection from campylobacter jejuni during short-term contamination events. a probabilistic hydraulic and risk model was used to evaluate the impact of multiple consumption events as ... | 2014 | 25473982 |
| inactivation of bacterial biothreat agents in water, a review. | water supplies and water distribution systems have been identified as potential targets for contamination by bacterial biothreat agents. since the 2001 bacillus anthracis bioterrorist attacks, additional efforts have been aimed at research to characterize biothreat organisms in regards to their susceptibility to disinfectants and technologies currently in use for potable water. here, we present a review of research relevant to disinfection of bacteria with the potential to pose a severe threat t ... | 2014 | 25473971 |
| serogroup-specific bacterial engineered glycoproteins as novel antigenic targets for diagnosis of shiga toxin-producing-escherichia coli-associated hemolytic-uremic syndrome. | human infection with shiga toxin-producing escherichia coli (stec) is a major cause of postdiarrheal hemolytic-uremic syndrome (hus), a life-threatening condition characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. e. coli o157:h7 is the dominant stec serotype associated with hus worldwide, although non-o157 stec serogroups can cause a similar disease. the detection of anti-o157 e. coli lipopolysaccharide (lps) antibodies in combination with stool culture and detection ... | 2014 | 25472487 |
| serogroup-specific bacterial engineered glycoproteins as novel antigenic targets for diagnosis of shiga toxin-producing-escherichia coli-associated hemolytic-uremic syndrome. | human infection with shiga toxin-producing escherichia coli (stec) is a major cause of postdiarrheal hemolytic-uremic syndrome (hus), a life-threatening condition characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. e. coli o157:h7 is the dominant stec serotype associated with hus worldwide, although non-o157 stec serogroups can cause a similar disease. the detection of anti-o157 e. coli lipopolysaccharide (lps) antibodies in combination with stool culture and detection ... | 2014 | 25472487 |
| intestinal colonization of broiler chickens by campylobacter spp. in an experimental infection study. | consumption of poultry meat is considered as one of the main sources of human campylobacteriosis, and there is clearly a need for new surveillance and control measures based on quantitative data on campylobacter spp. colonization dynamics in broiler chickens. we conducted four experimental infection trials, using four isolators during each infection trial to evaluate colonization of individual broiler chickens by campylobacter jejuni over time. individual and pooled faecal samples were obtained ... | 2015 | 25471550 |
| chemical composition, antibacterial and antioxidant activities of six essentials oils from the alliaceae family. | six essential oils (eos) from the alliaceae family, namely garlic (allium sativum), onion (allium cepa), leek (allium porrum), chinese chive (allium tuberosum), shallot (allium ascalonicum) and chive (allium schoenoprasum) were characterized by gc and gc-ms and evaluated for their functional food properties. antibacterial properties were tested on five food-borne pathogens: two gram-positive staphylococcus aureus (atcc 25923), listeria monocytogenes (atcc 19115) and three gram-negative salmonell ... | 2014 | 25470273 |
| microbiota alterations in acute and chronic gastrointestinal inflammation of cats and dogs. | the intestinal microbiota is the collection of the living microorganisms (bacteria, fungi, protozoa, and viruses) inhabiting the gastrointestinal tract. novel bacterial identification approaches have revealed that the gastrointestinal microbiota of dogs and cats is, similarly to humans, a highly complex ecosystem. studies in dogs and cats have demonstrated that acute and chronic gastrointestinal diseases, including inflammatory bowel disease (ibd), are associated with alterations in the small in ... | 2014 | 25469017 |
| participatory evaluation of chicken health and production constraints in ethiopia. | chicken production has a major role in the economy of developing countries and backyard production is particularly important to women. several programmes, in ethiopia and elsewhere, have attempted to improve chicken production as a means to reduce poverty. a key constraint to chicken production identified by farmers is disease. this study used participatory rural appraisal methods to work with chicken-keepers in order to prioritise chicken diseases, place these within the context of other produc ... | 2015 | 25466215 |
| impact of calcium signaling during infection of neisseria meningitidis to human brain microvascular endothelial cells. | the pili and outer membrane proteins of neisseria meningitidis (meningococci) facilitate bacterial adhesion and invasion into host cells. in this context expression of meningococcal pilc1 protein has been reported to play a crucial role. intracellular calcium mobilization has been implicated as an important signaling event during internalization of several bacterial pathogens. here we employed time lapse calcium-imaging and demonstrated that pilc1 of meningococci triggered a significant increase ... | 2014 | 25464500 |
| prevalence, virulence, and antimicrobial resistance of campylobacter jejuni and campylobacter coli in white stork ciconia ciconia in poland. | the aim of this study was to investigate the role of white stork ciconia ciconia as a potential reservoir of campylobacter spp. antimicrobial resistance and the presence of putative virulence genes of the isolates were also examined. a total of 398 white stork chicks sampled in western poland in habitats with high density of breeding were examined. rectal swabs were collected during breeding season 2009-2012 from storks developing in a relatively pure environment (odra meadows), in polluted area ... | 2015 | 25456607 |
| designing multiplex pcr system of campylobacter jejuni for efficient typing by improving monoplex pcr binary typing method. | campylobacter jejuni is responsible for the majority of campylobacter infections. as the molecular epidemiological study of outbreaks, pulsed-field gel electrophoresis (pfge) is performed in general. but pfge has several problems. pcr binary typing (p-bit) method is a typing method for campylobacter spp. that was recently developed, and was reported to have a similar discriminatory power and stability to those of pfge. we modified the p-bit method from 18 monoplex pcrs to two multiplex pcr syste ... | 2015 | 25455748 |
| klebsiella pneumoniae translocates across the intestinal epithelium via rho gtpase- and phosphatidylinositol 3-kinase/akt-dependent cell invasion. | klebsiella pneumoniae is an important pathogen that causes hospital-acquired septicemia and is associated with the recent emergence of community-acquired pyogenic liver abscess (pla). clinical typing suggests that k. pneumoniae infections originate from the gastrointestinal reservoir. however, the underlying mechanism remains unknown. here, we have sought to determine how k. pneumoniae penetrates the intestinal barrier. we identified that bacteremia and pla clinical isolates adhered to and invad ... | 2014 | 25452552 |
| klebsiella pneumoniae translocates across the intestinal epithelium via rho gtpase- and phosphatidylinositol 3-kinase/akt-dependent cell invasion. | klebsiella pneumoniae is an important pathogen that causes hospital-acquired septicemia and is associated with the recent emergence of community-acquired pyogenic liver abscess (pla). clinical typing suggests that k. pneumoniae infections originate from the gastrointestinal reservoir. however, the underlying mechanism remains unknown. here, we have sought to determine how k. pneumoniae penetrates the intestinal barrier. we identified that bacteremia and pla clinical isolates adhered to and invad ... | 2014 | 25452552 |
| crystal structures of sialyltransferase from photobacterium damselae. | sialyltransferase structures fall into either gt-a or gt-b glycosyltransferase fold. some sialyltransferases from the photobacterium genus have been shown to contain an additional n-terminal immunoglobulin (ig)-like domain. photobacterium damselae α2-6-sialyltransferase has been used efficiently in enzymatic and chemoenzymatic synthesis of α2-6-linked sialosides. here we report three crystal structures of this enzyme. two structures with and without a donor substrate analog cmp-3f(a)neu5ac conta ... | 2014 | 25451227 |
| analysis of neisseria gonorrhoeae azithromycin susceptibility in the united states by the gonococcal isolate surveillance project, 2005 to 2013. | azithromycin, administered with ceftriaxone, is recommended by the cdc for the treatment of gonorrhea. many experts have expressed concern about the ease with which neisseria gonorrhoeae can acquire macrolide resistance. we sought to describe gonococcal azithromycin susceptibility in the united states and to determine whether azithromycin susceptibility has changed over time. we analyzed data from 2005 to 2013 from the gonococcal isolate surveillance project, a cdc-supported sentinel surveillanc ... | 2015 | 25451056 |
| production of initial-stage eukaryotic n-glycan and its protein glycosylation in escherichia coli. | n-glycosylation is a ubiquitous protein post-translational modification mechanism in eukaryotes. in this work, a synthetic pathway containing glycosyltransferases from saccharomyces cerevisiae was introduced to escherichia coli to synthesize lipid-linked mannosyl-chitobiose (man-glcnac2) and trimannosyl-chitobiose (man3-glcnac2). transfer of man3-glcnac2 onto a model periplasmic protein occurred in the engineered e. coli cell using oligosaccharyltransferase pglb from campylobacter jejuni. mass s ... | 2015 | 25449758 |
| characterization and localization of the campylobacter jejuni transformation system proteins ctse, ctsp, and ctsx. | the human pathogen campylobacter jejuni is naturally competent for transformation with its own dna. genes required for efficient transformation in c. jejuni include those similar to components of type ii secretion systems found in many gram-negative bacteria (r. s. wiesner, d. r. hendrixson, and v. j. dirita, j bacteriol 185:5408-5418, 2003, http://dx.doi.org/10.1128/jb.185.18.5408-5418.2003). two of these, ctse and ctsp, encode proteins annotated as putative nucleotide binding nucleoside tripho ... | 2014 | 25448813 |
| characterization and localization of the campylobacter jejuni transformation system proteins ctse, ctsp, and ctsx. | the human pathogen campylobacter jejuni is naturally competent for transformation with its own dna. genes required for efficient transformation in c. jejuni include those similar to components of type ii secretion systems found in many gram-negative bacteria (r. s. wiesner, d. r. hendrixson, and v. j. dirita, j bacteriol 185:5408-5418, 2003, http://dx.doi.org/10.1128/jb.185.18.5408-5418.2003). two of these, ctse and ctsp, encode proteins annotated as putative nucleotide binding nucleoside tripho ... | 2014 | 25448813 |
| campylobacter jejuni, an uncommon cause of splenic abscess diagnosed by 16s rrna gene sequencing. | splenic abscess is a rare disease that primarily occurs in patients with splenic trauma, endocarditis, sickle cell anemia, or other diseases that compromise the immune system. this report describes a culture-negative splenic abscess in an immunocompetent patient caused by campylobacter jejuni, as determined by 16s rrna gene sequencing. | 2014 | 25447730 |
| effect of administration route and dose escalation on plasma and intestinal concentrations of enrofloxacin and ciprofloxacin in broiler chickens. | the (mis)use of fluoroquinolones in the fowl industry has led to an alarming incidence of fluoroquinolone resistance in pathogenic as well as commensal bacteria. next to simply reducing antimicrobial consumption, optimizing dosage regimens can be regarded as a suitable strategy to reduce antimicrobial resistance development without jeopardizing therapy efficacy and outcome. a first step in order to limit antimicrobial resistance is to assess the exposure of the intestinal microbiota to enrofloxa ... | 2014 | 25440469 |
| live genomics for pathogen monitoring in public health. | whole genome analysis based on next generation sequencing (ngs) now represents an affordable framework in public health systems. robust analytical pipelines of genomic data provides in short laps of time (hours) information about taxonomy, comparative genomics (pan-genome) and single polymorphisms profiles. pathogenic organisms of interest can be tracked at the genomic level, allowing monitoring at one-time several variables including: epidemiology, pathogenicity, resistance to antibiotics, viru ... | 2014 | 25437609 |
| comprehensive analysis of prokaryotes in environmental water using dna microarray analysis and whole genome amplification. | the microflora in environmental water consists of a high density and diversity of bacterial species that form the foundation of the water ecosystem. because the majority of these species cannot be cultured in vitro, a different approach is needed to identify prokaryotes in environmental water. a novel dna microarray was developed as a simplified detection protocol. multiple dna probes were designed against each of the 97,927 sequences in the dna data bank of japan and mounted on a glass chip in ... | 2013 | 25437334 |
| immune evasion, immunopathology and the regulation of the immune system. | costs and benefits of the immune response have attracted considerable attention in the last years among evolutionary biologists. given the cost of parasitism, natural selection should favor individuals with the most effective immune defenses. nevertheless, there exists huge variation in the expression of immune effectors among individuals. to explain this apparent paradox, it has been suggested that an over-reactive immune system might be too costly, both in terms of metabolic resources and risk ... | 2013 | 25436882 |
| an outbreak of campylobacter enteritis associated with a community water supply on a u.s. military installation. | an outbreak of acute gastroenteritis involving 249 persons, 32% of whom were hospitalized, occurred on a u.s. army installation in 1990. campylobacter jejuni was isolated from 81 of 163 (50%) persons cultured. seventeen isolates of c. jejuni available for serotyping were lior serotype 5. the outbreak remained restricted to one recruit barracks area and adjacent junior reserve officer training corps cadet barracks. infection of sequential cohorts of recruits over an interval of 3 weeks suggested ... | 2014 | 25436877 |
| exploring pfge for detecting large plasmids in campylobacter jejuni and campylobacter coli isolated from various retail meats. | campylobacter spp. is one of the most prevalent bacterial pathogens in retail meat, particularly poultry, and is a leading cause of diarrhea in humans. studies related to campylobacter large plasmids are limited in the literature possibly due to difficulty in isolating them using available alkaline lysis methods. the objectives of this study were to determine the prevalence of plasmids, particularly large ones, in campylobacter spp. isolated from various oklahoma retail meats, and to explore pfg ... | 2014 | 25436507 |
| global genome comparative analysis reveals insights of resistome and life-style adaptation of pseudomonas putida strain t2-2 in oral cavity. | most pseudomonas putida strains are environmental microorganisms exhibiting a wide range of metabolic capability but certain strains have been reported as rare opportunistic pathogens and some emerged as multidrug resistant p. putida. this study aimed to assess the drug resistance profile of, via whole genome analysis, p. putida strain t2-2 isolated from oral cavity. at the same time, we also compared the nonenvironmental strain with environmentally isolated p. putida. in silico comparative geno ... | 2014 | 25436236 |
| real-time comparative evaluation of biomerieux vitek ms versus bruker microflex ms, two matrix-assisted laser desorption-ionization time-of-flight mass spectrometry systems, for identification of clinically significant bacteria. | matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (maldi-tof ms) recently became available for the identification of bacteria in routine diagnostic laboratories. it is rapid and cost-effective and likely to replace phenotypic identification. this study was undertaken to compare two maldi-tof ms-based, bruker microflex ms (bms) and vitek ms (vms) systems, for identification (id) of clinically significant bacterial isolates. clinically relevant broad diversity of bacteri ... | 2014 | 25433488 |
| delayed-onset flaccid paralysis related to west nile virus reactivation following treatment with rituximab: a case report. | neurological manifestations of west nile virus infection include meningitis, encephalitis and acute flaccid paralysis. typically, west nile virus-associated acute flaccid paralysis is characterized by acute and rapidly progressing limb weakness, occurring early in the course of the disease. | 2014 | 25427863 |
| host-microbe interactions in the small bowel. | the intestine - home to a vast microbiome - balances its immune reactivity on a knife's edge. this review will summarize recent studies examining innate immune signals that shape the microbiota, and how pathogens can usurp protective responses to their advantage. | 2015 | 25426971 |
| population dynamics and ecology of arcobacter in sewage. | arcobacter species are highly abundant in sewage where they often comprise approximately 5-11% of the bacterial community. oligotyping of sequences amplified from the v4v5 region of the 16s rrna gene revealed arcobacter populations from different cities were similar and dominated by 1-3 members, with extremely high microdiversity in the minor members. overall, nine subgroups within the arcobacter genus accounted for >80% of the total arcobacter sequences in all samples analyzed. the distribution ... | 2014 | 25426103 |
| flexibility and symmetry of prokaryotic genome rearrangement reveal lineage-associated core-gene-defined genome organizational frameworks. | the prokaryotic pangenome partitions genes into core and dispensable genes. the order of core genes, albeit assumed to be stable under selection in general, is frequently interrupted by horizontal gene transfer and rearrangement, but how a core-gene-defined genome maintains its stability or flexibility remains to be investigated. based on data from 30 species, including 425 genomes from six phyla, we grouped core genes into syntenic blocks in the context of a pangenome according to their stabili ... | 2014 | 25425232 |
| autoimmunity links vinculin to the pathophysiology of chronic functional bowel changes following campylobacter jejuni infection in a rat model. | acute gastroenteritis can precipitate irritable bowel syndrome (ibs) in humans. cytolethal distending toxin is common to all pathogens causing gastroenteritis. its active subunit, cdtb, is associated with post-infectious bowel changes in a rat model of campylobacter jejuni infection, including small intestinal bacterial overgrowth (sibo). | 2015 | 25424202 |
| bacterial pathogen gene abundance and relation to recreational water quality at seven great lakes beaches. | quantitative assessment of bacterial pathogens, their geographic variability, and distribution in various matrices at great lakes beaches are limited. quantitative pcr (qpcr) was used to test for genes from e. coli o157:h7 (eaeo157), shiga-toxin producing e. coli (stx2), campylobacter jejuni (mapa), shigella spp. (ipah), and a salmonella enterica-specific (se) dna sequence at seven great lakes beaches, in algae, water, and sediment. overall, detection frequencies were mapa>stx2>ipah>se>eaeo157. ... | 2014 | 25423586 |
| acute hemorrhagic leukoencephalitis associated with autoimmune myopathy. | acute hemorrhagic leukoencephalitis is a rare acute inflammatory myelinopathy of central nervous system with high mortality. we report a case of an unusual presentation of acute hemorrhagic leukoencephalitis with autoimmune myopathy and a complete recovery with steroids and plasmapheresis. | 2014 | 25422709 |
| domain interactions control complex formation and polymerase specificity in the biosynthesis of the escherichia coli o9a antigen. | the escherichia coli o9a o-polysaccharide (o-ps) is a prototype for bacterial glycan synthesis and export by an atp-binding cassette transporter-dependent pathway. the o9a o-ps possesses a tetrasaccharide repeat unit comprising two α-(1→2)- and two α-(1→3)-linked mannose residues and is extended on a polyisoprenoid lipid carrier by the action of a polymerase (wbda) containing two glycosyltransferase active sites. the n-terminal domain of wbda possesses α-(1→2)-mannosyltransferase activity, and w ... | 2014 | 25422321 |
| domain interactions control complex formation and polymerase specificity in the biosynthesis of the escherichia coli o9a antigen. | the escherichia coli o9a o-polysaccharide (o-ps) is a prototype for bacterial glycan synthesis and export by an atp-binding cassette transporter-dependent pathway. the o9a o-ps possesses a tetrasaccharide repeat unit comprising two α-(1→2)- and two α-(1→3)-linked mannose residues and is extended on a polyisoprenoid lipid carrier by the action of a polymerase (wbda) containing two glycosyltransferase active sites. the n-terminal domain of wbda possesses α-(1→2)-mannosyltransferase activity, and w ... | 2014 | 25422321 |
| comparative effect of thymol or its glucose conjugate, thymol-β-d-glucopyranoside, on campylobacter in avian gut contents. | campylobacter jejuni is an important human food-borne pathogen that can contaminate meat and poultry during processing. consequently, strategies are sought to reduce the carriage of c. jejuni in food animals before they arrive at the abattoir. thymol is a natural product that reduces survivability of campylobacter in vitro, but its rapid absorption from the proximal alimentary tract limits its bactericidal efficacy in vivo. thymol-β-d-glucopyranoside is more resistant to absorption than free thy ... | 2015 | 25421628 |
| insights into potential pathogenesis mechanisms associated with campylobacter jejuni-induced abortion in ewes. | campylobacter jejuni is commonly found in the gastrointestinal tract of many food-animals including sheep without causing visible clinical symptoms of disease. however, c. jejuni has been implicated in ovine abortion cases worldwide. specifically, in the usa, the c. jejuni sheep abortion (sa) clone has been increasingly associated with sheep abortion. in vivo studies in sheep (the natural host) are needed to better characterize the virulence potential and pathogenesis of this clone. | 2014 | 25420712 |
| cross-feeding by bifidobacterium breve ucc2003 during co-cultivation with bifidobacterium bifidum prl2010 in a mucin-based medium. | bifidobacteria constitute a specific group of commensal bacteria that commonly inhabit the mammalian gastrointestinal tract. bifidobacterium breve ucc2003 was previously shown to utilize a variety of plant/diet/host-derived carbohydrates, including cellodextrin, starch and galactan, as well as the mucin and hmo-derived monosaccharide, sialic acid. in the current study, we investigated the ability of this strain to utilize parts of a host-derived source of carbohydrate, namely the mucin glycoprot ... | 2014 | 25420416 |
| avoidance of antibiotic administration to campylobacter enterocolitis mimicking severe salmonellosis by clinical and laboratory features. | to compare the clinical and laboratory features of non-typhoid salmonella (nts) and campylobacter jejuni enterocolitis in children and formulate a risk scoring system (with receiver-operating characteristic curve) to facilitate early decision making and avoid antibiotic overuse in c. jejuni enterocolitis. | 2015 | 25418893 |
| systematic review and meta-analysis of the proportion of campylobacter cases that develop chronic sequelae. | understanding of chronic sequelae development after campylobacter infection is limited. the objective of the study was to determine via systematic review and meta-analysis the proportion of campylobacter cases that develop chronic sequelae. | 2014 | 25416162 |
| norepinephrine and dopamine increase motility, biofilm formation, and virulence of vibrio harveyi. | vibrio harveyi is one of the major pathogens of aquatic organisms, affecting both vertebrates and invertebrates, and causes important losses in the aquaculture industry. in order to develop novel methods to control disease caused by this pathogen, we need to obtain a better understanding of pathogenicity mechanisms. sensing of catecholamines increases both growth and production of virulence-related factors in pathogens of terrestrial animals and humans. however, at this moment, knowledge on the ... | 2014 | 25414697 |
| metagenomes of microbial communities in arsenic- and pathogen-contaminated well and surface water from bangladesh. | the contamination of drinking water from both arsenic and microbial pathogens occurs in bangladesh. a general metagenomic survey of well water and surface water provided information on the types of pathogens present and may help elucidate arsenic metabolic pathways and potential assay targets for monitoring surface-to-ground water pathogen transport. | 2014 | 25414497 |
| cd169-dependent cell-associated hiv-1 transmission: a driver of virus dissemination. | sexual transmission of human immunodeficiency virus type 1 (hiv-1) occurs across mucosal surfaces of the genital and gastrointestinal tracts and accounts for the vast majority of newly acquired infections worldwide. in the absence of an effective vaccine, interventional strategies such as microbicides that target viral attachment and entry into mucosa-resident target cells are particularly attractive and might have the greatest impact on reducing the hiv-1 pandemic. rational development of micro ... | 2014 | 25414418 |
| pen and pal are nucleotide-sugar dehydratases that convert udp-glcnac to udp-6-deoxy-d-glcnac-5,6-ene and then to udp-4-keto-6-deoxy-l-altnac for cmp-pseudaminic acid synthesis in bacillus thuringiensis. | cmp-pseudaminic acid is a precursor required for the o-glycosylation of flagellin in some pathogenic gram-negative bacteria, a process known to be critical in bacterial motility and infection. however, little is known about flagellin glycosylation in gram-positive bacteria. here, we identified and functionally characterized an operon, named bti_pse, in bacillus thuringiensis israelensis atcc 35646, which encodes seven different enzymes that together convert udp-glcnac to cmp-pseudaminic acid. in ... | 2014 | 25414257 |
| pen and pal are nucleotide-sugar dehydratases that convert udp-glcnac to udp-6-deoxy-d-glcnac-5,6-ene and then to udp-4-keto-6-deoxy-l-altnac for cmp-pseudaminic acid synthesis in bacillus thuringiensis. | cmp-pseudaminic acid is a precursor required for the o-glycosylation of flagellin in some pathogenic gram-negative bacteria, a process known to be critical in bacterial motility and infection. however, little is known about flagellin glycosylation in gram-positive bacteria. here, we identified and functionally characterized an operon, named bti_pse, in bacillus thuringiensis israelensis atcc 35646, which encodes seven different enzymes that together convert udp-glcnac to cmp-pseudaminic acid. in ... | 2014 | 25414257 |
| reactions of chicken sera to recombinant campylobacter jejuni flagellar proteins. | campylobacter jejuni is a gram-negative spiral rod bacterium and is the leading but underreported bacterial food-borne pathogen that causes human campylobacteriosis worldwide. raw or undercooked poultry products are regarded as a major source for human infection. c. jejuni flagella have been implicated in colonization and adhesion to the mucosal surface of chicken gastrointestinal tracts. therefore, flagellar proteins would be the excellent targets for further investigation. in this report, we u ... | 2015 | 25413671 |
| first case report of fatal sepsis due to campylobacter upsaliensis. | we encountered a rare case of severe fatal infection in a 70-year-old woman due to campylobacter upsaliensis, identified by pcr amplification and sequencing analysis of the 16s rrna gene using dna extracted from the isolates. to our knowledge, fatal sepsis due to this organism has never been described to date. | 2014 | 25411172 |
| first case report of fatal sepsis due to campylobacter upsaliensis. | we encountered a rare case of severe fatal infection in a 70-year-old woman due to campylobacter upsaliensis, identified by pcr amplification and sequencing analysis of the 16s rrna gene using dna extracted from the isolates. to our knowledge, fatal sepsis due to this organism has never been described to date. | 2014 | 25411172 |
| genetic diversity of campylobacter jejuni isolates from korea and travel-associated cases from east and southeast asian countries. | forty domestic and travel-associated campylobacter jejuni isolates were analyzed by profiling 7 pathogenic genes (cdtb, cadf, cj0131, ciab, racr, wlan, and virb11) along with multilocus sequence typing (mlst) and antimicrobial susceptibility testing. cdtb, cadf, and cj0131 were present in all isolates, whereas virb11 was not detected in either domestic or travel-associated isolates. ciab was present in all domestic isolates and 94% of travel-associated isolates. the respective detection rates of ... | 2014 | 25410568 |
| comparison of two methods of bacterial dna extraction from human fecal samples contaminated with clostridium perfringens, staphylococcus aureus, salmonella typhimurium, and campylobacter jejuni. | in this study, 2 methods of dna extraction were evaluated for use in conjunction with the screening system rapid foodborne bacterial screening 24 (rfbs24), which employs multiplex real-time sybr green polymerase chain reaction (sg-pcr) and can simultaneously detect 24 target genes of foodborne pathogens in fecal dna samples. the qiaamp dna stool mini kit (qkit) and ultra clean fecal dna isolation kit (ukit) were used for bacterial dna extraction from fecal samples artificially inoculated with cl ... | 2014 | 25410559 |
| prevalence and antimicrobial susceptibility of campylobacter spp. in oklahoma conventional and organic retail poultry. | campylobacter is one of the most important foodborne pathogens that cause bacterial gastroenteritis.this study was conducted to investigate the prevalence and antimicrobial resistance of campylobacter in conventional and organic retail poultry samples purchased from grocery stores in tulsa, oklahoma.one hundred and fifty six chilled retail chicken samples (85 conventional and 71 organic) and 65 chilled retail conventional turkey samples were collected in this study. the prevalence of campylobact ... | 2014 | 25408778 |
| in vivo function and comparative genomic analyses of the drosophila gut microbiota identify candidate symbiosis factors. | symbiosis is often characterized by co-evolutionary changes in the genomes of the partners involved. an understanding of these changes can provide insight into the nature of the relationship, including the mechanisms that initiate and maintain an association between organisms. in this study we examined the genome sequences of bacteria isolated from the drosophila melanogaster gut with the objective of identifying genes that are important for function in the host. we compared microbiota isolates ... | 2014 | 25408687 |
| outbreaks associated with cantaloupe, watermelon, and honeydew in the united states, 1973-2011. | fresh fruits and vegetables are an important part of a healthy diet. melons have been associated with enteric infections. we reviewed outbreaks reported to the centers for disease control and prevention's foodborne disease outbreak surveillance system during 1973-2011 in which the implicated food was a single melon type. we also reviewed published literature and records obtained from investigating agencies. during 1973-2011, 34 outbreaks caused by a single melon type were reported, resulting in ... | 2014 | 25407556 |
| lymphotoxin-light pathway regulates the interferon signature in rheumatoid arthritis. | a subset of patients with autoimmune diseases including rheumatoid arthritis (ra) and lupus appear to be exposed continually to interferon (ifn) as evidenced by elevated expression of ifn induced genes in blood cells. in lupus, detection of endogenous chromatin complexes by the innate sensing machinery is the suspected driver for the ifn, but the actual mechanisms remain unknown in all of these diseases. we investigated in two randomized clinical trials the effects on ra patients of baminercept, ... | 2014 | 25405351 |
| comparison of intestinal bacterial populations between two dairy cattle herds colonized or not by campylobacter jejuni. | campylobacter jejuni is an important foodborne pathogen. it can be isolated from bovine feces and its presence is influenced by farm characteristics and management practices. the impact of the bovine gut microbiota on the presence of c. jejuni is poorly documented. two herds of lactating cows were selected: one where c. jejuni was not detected in 20 animals and the other where 55% of the sampled animals (11/20) were contaminated by c. jejuni. the bacterial diversity of bovine feces from these tw ... | 2014 | 25405278 |
| the gut microbiome and the brain. | the human gut microbiome impacts human brain health in numerous ways: (1) structural bacterial components such as lipopolysaccharides provide low-grade tonic stimulation of the innate immune system. excessive stimulation due to bacterial dysbiosis, small intestinal bacterial overgrowth, or increased intestinal permeability may produce systemic and/or central nervous system inflammation. (2) bacterial proteins may cross-react with human antigens to stimulate dysfunctional responses of the adaptiv ... | 2014 | 25402818 |
| evidence of land-sea transfer of the zoonotic pathogen campylobacter to a wildlife marine sentinel species. | environmental pollution often accompanies the expansion and urbanization of human populations where sewage and wastewaters commonly have an impact on the marine environments. here, we explored the potential for faecal bacterial pathogens, of anthropic origin, to spread to marine wildlife in coastal areas. the common zoonotic bacterium campylobacter was isolated from grey seals (halichoerus grypus), an important sentinel species for environmental pollution, and compared to isolates from wild bird ... | 2015 | 25401947 |
| helicobacter pylori and neurological diseases: married by the laws of inflammation. | the purpose of this paper is to review current information about the role of inflammation caused by helicobacter pylori (h. pylori) infection in neurological diseases such as parkinson's disease, alzheimer's disease, guillain-barré syndrome, multiple sclerosis, and other inflammatory diseases including ischemic stroke. infection with h. pylori usually persists throughout life, resulting in a chronic inflammatory response with local secretion of numerous inflammatory mediators including chemokine ... | 2014 | 25400983 |
| acute hemiplegia as a rare presentation of infantile guillain-barre syndrome. | 2014 | 25399226 | |
| intraspecies comparison of streptomyces pratensis genomes reveals high levels of recombination and gene conservation between strains of disparate geographic origin. | streptomyces are widespread bacteria that contribute to the terrestrial carbon cycle and produce the majority of clinically useful antibiotics. while interspecific genomic diversity has been investigated among streptomyces, information is lacking on intraspecific genomic diversity. streptomyces pratensis has high rates of homologous recombination but the impact of such gene exchange on genome evolution and the evolution of natural product gene clusters remains uncharacterized. | 2014 | 25399205 |
| characterization of campylobacter jejuni and campylobacter coli genotypes in poultry flocks by restriction fragment length polymorphism (rflp) analysis. | we describe a simple, rapid, and discriminatory methodology that allows the routine molecular characterization of campylobacter jejuni and campylobacter coli isolates. the proposed approach is built on one of the earliest and simplest molecular typing methods ever, consisting on the analysis of the fragments of different lengths generated by digestion of homologous dna sequences with specific restriction endonucleases, a process known as restriction fragment length polymorphism (rflp) analysis. ... | 2015 | 25399105 |
| from deep-sea volcanoes to human pathogens: a conserved quorum-sensing signal in epsilonproteobacteria. | chemosynthetic epsilonproteobacteria from deep-sea hydrothermal vents colonize substrates exposed to steep thermal and redox gradients. in many bacteria, substrate attachment, biofilm formation, expression of virulence genes and host colonization are partly controlled via a cell density-dependent mechanism involving signal molecules, known as quorum sensing. within the epsilonproteobacteria, quorum sensing has been investigated only in human pathogens that use the luxs/autoinducer-2 (ai-2) mecha ... | 2014 | 25397946 |
| from deep-sea volcanoes to human pathogens: a conserved quorum-sensing signal in epsilonproteobacteria. | chemosynthetic epsilonproteobacteria from deep-sea hydrothermal vents colonize substrates exposed to steep thermal and redox gradients. in many bacteria, substrate attachment, biofilm formation, expression of virulence genes and host colonization are partly controlled via a cell density-dependent mechanism involving signal molecules, known as quorum sensing. within the epsilonproteobacteria, quorum sensing has been investigated only in human pathogens that use the luxs/autoinducer-2 (ai-2) mecha ... | 2014 | 25397946 |
| peripheral cd4+ t cell cytokine responses following human challenge and re-challenge with campylobacter jejuni. | campylobacter jejuni is a leading cause of human gastroenteritis worldwide; however, our understanding of the human immune response to c. jejuni infection is limited. a previous human challenge model has shown that c. jejuni elicits ifnγ production by peripheral blood mononuclear cells, a response associated with protection from clinical disease following re-infection. in this study, we investigate t lymphocyte profiles associated with campylobacteriosis using specimens from a new human challeng ... | 2014 | 25397604 |
| antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens. | the growing number of bacterial pathogens that are resistant to numerous antibiotics is a cause for concern around the globe. there have been no new broad-spectrum antibiotics developed in the last 40 years, and the drugs we have currently are quickly becoming ineffective. in this article, we explore a range of therapeutic strategies that could be employed in conjunction with antibiotics and may help to prolong the life span of these life-saving drugs. discussed topics include antiresistance dru ... | 2014 | 25393203 |
| antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens. | the growing number of bacterial pathogens that are resistant to numerous antibiotics is a cause for concern around the globe. there have been no new broad-spectrum antibiotics developed in the last 40 years, and the drugs we have currently are quickly becoming ineffective. in this article, we explore a range of therapeutic strategies that could be employed in conjunction with antibiotics and may help to prolong the life span of these life-saving drugs. discussed topics include antiresistance dru ... | 2014 | 25393203 |
| structural and functional characterization of methicillin-resistant staphylococcus aureus's class iib fructose 1,6-bisphosphate aldolase. | staphylococcus aureus is one of the most common nosocomial sources of soft-tissue and skin infections and has more recently become prevalent in the community setting as well. since the use of penicillins to combat s. aureus infections in the 1940s, the bacterium has been notorious for developing resistances to antibiotics, such as methicillin-resistant staphylococcus aureus (mrsa). with the persistence of mrsa as well as many other drug resistant bacteria and parasites, there is a growing need t ... | 2014 | 25390935 |
| a linkage between smeijk efflux pump, cell envelope integrity, and σe-mediated envelope stress response in stenotrophomonas maltophilia. | resistance nodulation division (rnd) efflux pumps, such as the smeijk pump of stenotrophomonas maltophilia, are known to contribute to the multidrug resistance in gram-negative bacteria. however, some rnd pumps are constitutively expressed even though no antimicrobial stresses occur, implying that there should be some physical implications for these rnd pumps. in this study, the role of smeijk in antimicrobials resistance, envelope integrity, and σe-mediated envelope stress response (esr) of s. ... | 2014 | 25390933 |
| multilocus sequence typing of campylobacter jejuni and campylobacter coli from humans and chickens in north-eastern italy. | this paper reports the multilocus sequence typing (mlst) of 57 c. jejuni and c. coli isolates from humans and chickens in italy and the identification of 17 new sequence types (sts). a high genetic diversity was detected among c. jejuni/c. coli and human/chicken isolates, with a predominance of clonal complexes cc21 and cc828. although human sts were not the same as those found in chickens, 3 ccs overlapped between human and chicken isolates. genotyping of campylobacter strains by mlst should be ... | 2014 | 25387294 |
| the impact of the milk glycobiome on the neonate gut microbiota. | human milk is a complete source of nourishment for the infant. exclusive breastfeeding not only sustains the infant's development but also guides the proliferation of a protective intestinal microbiota. among the many components of milk that modulate the infant gut microbiota, the milk glycans, which comprise free oligosaccharides, glycoproteins, and glycolipids, are increasingly recognized as drivers of microbiota development and overall gut health. these glycans may display pleiotropic functio ... | 2014 | 25387230 |
| the impact of the milk glycobiome on the neonate gut microbiota. | human milk is a complete source of nourishment for the infant. exclusive breastfeeding not only sustains the infant's development but also guides the proliferation of a protective intestinal microbiota. among the many components of milk that modulate the infant gut microbiota, the milk glycans, which comprise free oligosaccharides, glycoproteins, and glycolipids, are increasingly recognized as drivers of microbiota development and overall gut health. these glycans may display pleiotropic functio ... | 2014 | 25387230 |
| top-down strategies for the structural elucidation of intact gram-negative bacterial endotoxins. | re-modelling of lipopolysaccharides, which are the primary constituent of the outer cell membrane of gram-negative bacteria, modulates pathogenesis and resistance to microbials. reported herein is the characterization of intact gram-negative bacterial lipooligosaccharides (los) via a new strategy utilizing online liquid chromatography (lc) coupled with ultraviolet photodissociation (uvpd) mass spectrometry. compared to collision-based ms/ms methods, uvpd and uvpd/hcd promoted a greater array of ... | 2014 | 25386333 |
| comparative genomics of the campylobacter lari group. | the campylobacter lari group is a phylogenetic clade within the epsilon subdivision of the proteobacteria and is part of the thermotolerant campylobacter spp., a division within the genus that includes the human pathogen campylobacter jejuni. the c. lari group is currently composed of five species (c. lari, campylobacter insulaenigrae, campylobacter volucris, campylobacter subantarcticus, and campylobacter peloridis), as well as a group of strains termed the urease-positive thermophilic campylob ... | 2014 | 25381664 |
| crystal structure of the hiv neutralizing antibody 2g12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose. | human immunodeficiency virus-1 (hiv-1) is a major public health threat that continues to infect millions of people worldwide each year. a prophylactic vaccine remains the most cost-effective way of globally reducing and eliminating the spread of the virus. the hiv envelope spike, which is the target of many vaccine design efforts, is densely mantled with carbohydrate and several potent broadly neutralizing antibodies to hiv-1 recognize carbohydrate on the envelope spike as a major part of their ... | 2014 | 25380763 |
| crystal structure of the hiv neutralizing antibody 2g12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose. | human immunodeficiency virus-1 (hiv-1) is a major public health threat that continues to infect millions of people worldwide each year. a prophylactic vaccine remains the most cost-effective way of globally reducing and eliminating the spread of the virus. the hiv envelope spike, which is the target of many vaccine design efforts, is densely mantled with carbohydrate and several potent broadly neutralizing antibodies to hiv-1 recognize carbohydrate on the envelope spike as a major part of their ... | 2014 | 25380763 |
| overlapping guillain-barré syndrome and bickerstaff's brainstem encephalitis associated with epstein barr virus. | a flaccid tetraparesis in bickerstaff's brainstem encephalitis (bbe) is presumed to be a sign of overlapping guillain-barré syndrome (gbs). in addition, bbe and fisher syndrome, which are clinically similar and are both associated with the presence of the immunoglobulin g anti-gq1b antibody, represent a specific autoimmune disease with a wide spectrum of symptoms that include ophthalmoplegia and ataxia. a 2-year-old boy presented with rapidly progressive ophthalmoplegia, ataxia, hyporeflexia, we ... | 2014 | 25379047 |
| effect of the l499m mutation of the ascomycetous botrytis aclada laccase on redox potential and catalytic properties. | laccases are members of a large family of multicopper oxidases that catalyze the oxidation of a wide range of organic and inorganic substrates accompanied by the reduction of dioxygen to water. these enzymes contain four cu atoms per molecule organized into three sites: t1, t2 and t3. in all laccases, the t1 copper ion is coordinated by two histidines and one cysteine in the equatorial plane and is covered by the side chains of hydrophobic residues in the axial positions. the redox potential of ... | 2014 | 25372682 |
| structural basis for the recognition of muramyltripeptide by helicobacter pylori csd4, a d,l-carboxypeptidase controlling the helical cell shape. | helicobacter pylori infection causes a variety of gastrointestinal diseases, including peptic ulcers and gastric cancer. its colonization of the gastric mucosa of the human stomach is a prerequisite for survival in the stomach. colonization depends on its motility, which is facilitated by the helical shape of the bacterium. in h. pylori, cross-linking relaxation or trimming of peptidoglycan muropeptides affects the helical cell shape. csd4 has been identified as one of the cell shape-determining ... | 2014 | 25372672 |
| diagnostic yields in solid organ transplant recipients admitted with diarrhea. | although diarrhea is a frequent complaint among solid organ transplant recipients, the contribution of infectious etiologies remains incompletely defined. we sought to define the etiologies of diarrhea and the yields of testing at our institution. | 2014 | 25371488 |
| diagnostic yields in solid organ transplant recipients admitted with diarrhea. | although diarrhea is a frequent complaint among solid organ transplant recipients, the contribution of infectious etiologies remains incompletely defined. we sought to define the etiologies of diarrhea and the yields of testing at our institution. | 2014 | 25371488 |