Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| the dynamic expression of potential mediators of severe acute respiratory syndrome coronavirus 2 cellular entry in fetal, neonatal, and adult rhesus monkeys. | the coronavirus disease 2019 (covid-19) pandemic, induced by the pathogenic severe acute respiratory syndrome coronavirus 2 (sars-cov-2), has spread rapidly all over the world. there is considerable variability among neonates, children, and adults in the incidence of infection and severe disease following exposure to sars-cov-2. in our study, we analyzed the transcriptome data of primate animal model of rhesus monkeys to evaluate the expression levels of possible sars-cov-2 receptors and proteas ... | 2021 | 33537060 |
| high-level expression of the monomeric sars-cov-2 s protein rbd 320-537 in stably transfected cho cells by the eef1a1-based plasmid vector. | the spike (s) protein is one of the three proteins forming the coronaviruses' viral envelope. the s protein of the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has a spatial structure similar to the s proteins of other mammalian coronaviruses, except for a unique receptor-binding domain (rbd), which is a significant inducer of host immune response. recombinant sars-cov-2 rbd is widely used as a highly specific minimal antigen for serological tests. correct exposure of antigenic d ... | 2021 | 33529230 |
| dromedary camels as a natural source of neutralizing nanobodies against sars-cov-2. | the development of prophylactic and therapeutic agents for coronavirus disease 2019 (covid-19) is a current global health priority. here, we investigated the presence of cross-neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) in dromedary camels that were middle east respiratory syndrome coronavirus (mers-cov) seropositive but mers-cov free. the tested 229 dromedaries had anti-mers-cov camel antibodies with variable cross-reactivity patterns against sar ... | 2021 | 33529170 |
| regeneration profiles of olfactory epithelium after sars-cov-2 infection in golden syrian hamsters. | olfactory dysfunction is one of the most frequent and specific symptoms of coronavirus disease 2019 (covid-19). information on the damage and repair of the neuroepithelium and its impact on olfactory function after covid-19 is still incomplete. while severe acute respiratory syndrome coronavirus-2 (sars-cov-2) causes the ongoing worldwide outbreak of covid-19, little is known about the changes triggered by sars-cov-2 in the olfactory epithelium (oe) at the cellular level. here, we report profile ... | 2021 | 33522795 |
| evaluation of a real-time rt-pcr panel for detection of sars-cov-2 in bat guano. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is the causative agent of coronavirus disease 2019 (covid-19), which is an ongoing global health concern. the exact source of the virus has not been identified, but it is believed that this novel coronavirus originated in animals; bats in particular have been implicated as the primary reservoir of the virus. sars-cov-2 can also be transmitted from humans to other animals, including tigers, cats, and mink. consequently, infected people ... | 2021 | 33522461 |
| immunogenicity and protective efficacy of bbv152, whole virion inactivated sars- cov-2 vaccine candidates in the syrian hamster model. | the availability of a safe and effective vaccine would be the eventual measure to deal with severe acute respiratory syndrome coronavirus-2 (sars-cov-2) threat. here, we have assessed the immunogenicity and protective efficacy of inactivated sars-cov-2 vaccine candidates bbv152a, bbv152b, and bbv152c in syrian hamsters. three dose vaccination regimes with vaccine candidates induced significant titers of sars-cov-2-specific igg and neutralizing antibodies. bbv152a and bbv152b vaccine candidates r ... | 2021 | 33521604 |
| research note: indian poultry industry vis-à-vis coronavirus disease 2019: a situation analysis report. | originating in wuhan city, hubei province of china, and rapid spread to multiple countries, severe acute respiratory syndrome coronavirus 2 has emerged as a novel public health emergence. during early february, spread of misinformation and rumors driven by the fear of linking chicken meat and eggs in the transmission of coronavirus disease 2019 (covid-19) among human population is witnessed in india. this resulted drastic reduction in consumption of poultry products with subsequent fall in deman ... | 2020 | 33516485 |
| absence of vaccine-enhanced disease with unexpected positive protection against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) by inactivated vaccine given within 3 days of virus challenge in syrian hamster model. | mass vaccination against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is ongoing amidst widespread transmission during the coronavirus disease-2019 (covid-19) pandemic. disease phenotypes of sars-cov-2 exposure occurring around the time of vaccine administration have not been described. | 2021 | 33515458 |
| sars-cov-2 causes a systemically multiple organs damages and dissemination in hamsters. | severe acute respiratory syndrome coronavirus-2 (sars-cov-2) has spread across the world and impacted global healthcare systems. for clinical patients, covid-19 not only induces pulmonary lesions but also affects extrapulmonary organs. an ideal animal model that mimics covid-19 in humans in terms of the induced systematic lesions is urgently needed. here, we report that syrian hamster is highly permissive to sars-cov-2 and exhibit diffuse alveolar damage and induced extrapulmonary multi-organs d ... | 2021 | 33510731 |
| rapid protection from covid-19 in nonhuman primates vaccinated intramuscularly but not intranasally with a single dose of a recombinant vaccine. | the ongoing pandemic of coronavirus disease 2019 (covid-19) continues to exert a significant burden on health care systems worldwide. with limited treatments available, vaccination remains an effective strategy to counter transmission of severe acute respiratory syndrome coronavirus 2 (sars-cov-2). recent discussions concerning vaccination strategies have focused on identifying vaccine platforms, number of doses, route of administration, and time to reach peak immunity against sars-cov-2. here, ... | 2021 | 33501447 |
| protective immunity and persistent lung sequelae in domestic cats after sars-cov-2 infection. | severe acute respiratory syndrome coronavirus 2 readily transmits between domestic cats. we found that domestic cats that recover from an initial infection might be protected from reinfection. however, we found long-term persistence of inflammation and other lung lesions after infection, despite a lack of clinical symptoms and limited viral replication in the lungs. | 2021 | 33496650 |
| the rhinolophus affinis bat ace2 and multiple animal orthologs are functional receptors for bat coronavirus ratg13 and sars-cov-2. | bat coronavirus (cov) ratg13 shares the highest genome sequence identity with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) among all known coronaviruses, and also uses human angiotensin converting enzyme 2 (hace2) for virus entry. thus, sars-cov-2 is thought to have originated from bat. however, whether sars-cov-2 emerged from bats directly or through an intermediate host remains elusive. here, we found that rhinolophus affinis bat ace2 (raace2) is an entry receptor for both sars ... | 2021 | 33495713 |
| sars-cov-2 infection and longitudinal fecal screening in malayan tigers (panthera tigris jacksoni), amur tigers (panthera tigris altaica ), and african lions (panthera leo krugeri) at the bronx zoo, new york, usa. | severe acute respiratory syndrome coronavirus-2 (sars-cov-2) emerged as the cause of a global pandemic in 2019-2020. in march 2020, new york city became the epicenter in the united states for the pandemic. on 27 march 2020, a malayan tiger (panthera tigris jacksoni) at the bronx zoo in new york city developed a cough and wheezing with subsequent inappetence. over the next week, an additional malayan tiger and two amur tigers (panthera tigris altaica) in the same building and three lions (panther ... | 2021 | 33480553 |
| coronaviruses associated with the superfamily musteloidea. | among the animal superfamily musteloidea, which includes those commonly known as mustelids, naturally occurring and species-specific alphacoronavirus infections have been observed in both mink (mustela vison/neovison vison) and domestic ferrets (mustela putorius furo). ferret systemic coronavirus (frscv), in particular, has been associated with a rare but fatal systemic disease. in recent months, it has become apparent that both minks and ferrets are susceptible to severe acute respiratory syndr ... | 2021 | 33468694 |
| bats, pangolins, minks and other animals - villains or victims of sars-cov-2? | coronavirus disease-19 (covid-19) is caused by the severe acute respiratory syndrome coronavirus-2 (sars-cov-2), which has become unstoppable, spreading rapidly worldwide and, consequently, reaching a pandemic level. this review aims to provide the information available so far on the likely animal origin of sars-cov-2 and its possible hosts/reservoirs as well as all natural animal infections and experimental evidence using animal models. horseshoe bats from the species rhinolophus affinis seem t ... | 2021 | 33464439 |
| sars-cov-2, the pandemic coronavirus: molecular and structural insights. | the outbreak of a novel coronavirus associated with acute respiratory disease, called covid-19, marked the introduction of the third spillover of an animal coronavirus (cov) to humans in the last two decades. the genome analysis with various bioinformatics tools revealed that the causative pathogen (sars-cov-2) belongs to the subgenus sarbecovirus of the genus betacoronavirus, with highly similar genome as bat coronavirus and receptor-binding domain (rbd) of spike glycoprotein as malayan pangoli ... | 2021 | 33460172 |
| geriatric challenges in the new coronavirus disease-19 (covid-19) pandemic: a systematic review. | background: during the covid-19 pandemic, elderly individuals (with the chronological age of 65 years and above) are more susceptible to the sars-cov-2 infection complications due to altered immune system response and the higher rate of underlying comorbidities. a vast majority of mortalities are reported in elderly patients; thus, this study aimed to evaluate complications of covid-19 in elderly patients. methods: a systematic review was conducted according to moose guidelines. science direct, ... | 2020 | 33437719 |
| a therapeutic neutralizing antibody targeting receptor binding domain of sars-cov-2 spike protein. | vaccines and therapeutics are urgently needed for the pandemic caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2). here, we screen human monoclonal antibodies (mab) targeting the receptor binding domain (rbd) of the viral spike protein via antibody library constructed from peripheral blood mononuclear cells of a convalescent patient. the ct-p59 mab potently neutralizes sars-cov-2 isolates including the d614g variant without antibody-dependent enhancement effect. complex cryst ... | 2021 | 33436577 |
| single-cell rna sequencing reveals sars-cov-2 infection dynamics in lungs of african green monkeys. | detailed knowledge about the dynamics of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection is important for uncovering the viral and host factors that contribute to coronavirus disease 2019 (covid-19) pathogenesis. old-world nonhuman primates recapitulate mild to moderate cases of covid-19, thereby serving as important pathogenesis models. we compared african green monkeys inoculated with infectious sars-cov-2 or irradiated, inactivated virus to study the dynamics of virus r ... | 2021 | 33431511 |
| neutralizing antibody-dependent and -independent immune responses against sars-cov-2 in cynomolgus macaques. | we examined the pathogenicity of severe acute respiratory syndrome coronavirus-2 (sars-cov-2) in cynomolgus macaques for 28 days to establish an animal model of covid-19 for the development of vaccines and antiviral drugs. cynomolgus macaques infected with sars-cov-2 showed body temperature rises and x-ray radiographic pneumonia without life-threatening clinical signs of disease. a neutralizing antibody against sars-cov-2 and t-lymphocytes producing interferon (ifn)-γ specifically for sars-cov-2 ... | 2020 | 33412411 |
| in vitro characterisation of sars-cov-2 and susceptibility of domestic ferrets (mustela putorius furo). | severe acute respiratory syndrome coronavirus-2 (sars-cov-2) is an emerging virus that has caused significant human morbidity and mortality since its detection in late 2019. with the rapid emergence has come an unprecedented programme of vaccine development with at least 300 candidates under development. ferrets have proven to be an appropriate animal model for testing safety and efficacy of sars-cov-2 vaccines due to quantifiable virus shedding in nasal washes and oral swabs. here, we outline o ... | 2021 | 33400387 |
| induction of alarmin s100a8/a9 mediates activation of aberrant neutrophils in the pathogenesis of covid-19. | the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) pandemic poses an unprecedented public health crisis. evidence suggests that sars-cov-2 infection causes dysregulation of the immune system. however, the unique signature of early immune responses remains elusive. we characterized the transcriptome of rhesus macaques and mice infected with sars-cov-2. alarmin s100a8 was robustly induced in sars-cov-2-infected animal models as well as in covid-19 patients. paquinimod, a specific inh ... | 2020 | 33388094 |
| mutational spectra of sars-cov-2 isolated from animals. | coronaviruses are ubiquitous and infect a wide spectrum of animals and humans. the newly emerged severe acute respiratory syndrome coronavirus-2 (sars-cov-2) has become a worldwide pandemic. to address the role that animals may play in the evolution of sars-cov-2, the full genome sequences of sars-cov-2 isolated from animals were compared with sars-cov-2 human isolates from the same clade and geographic region. phylogenetic analysis of sars-cov-2 isolated from the cat, dog, mink, mouse, and tige ... | 2020 | 33384909 |
| progress in source tracking of sars-cov-2. | coronavirus disease 2019 (covid-19) pandemic has caused a total of 55 928 327 confirmed cases and 1 344 003 deaths as of november 19, 2020. but so far the origin of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) that causes this pandemic has remained undetermined. the purpose of this study is to review the current research of sars-cov-2 and the existing problems therein, which may provide inspiration for further researches. existing evidence suggested that sars-cov-2 may be derived ... | 2020 | 33380405 |
| bioinformatic evaluation of the potential animal models for studying sars-cov-2. | recently, the severe acute respiratory syndrome coronavirus 2 (sars-cov-2), a novel coronavirus, which results in corona virus disease 2019 (covid-19), has caused over 40 millions of people infected and over 1 million fatalities, challenging the public health. the recognition of its functional receptor, angiotensin converting enzyme 2 (ace2), have facilitated the antivirus drugs testing and vaccines development. due to the natural resistance of mouse model to sars-cov-2, there is an urgent need ... | 2020 | 33364494 |
| an overview of sars-cov-2 and animal infection. | a novel coronavirus has been reported as the causative pathogen of the coronavirus disease 2019 (covid-19) outbreak in wuhan city, china in december 2019. due to the rapid spread of the virus worldwide, it has been announced as a pandemic by the world health organization (who). hospitalized patients in wuhan were associated with the huanan seafood wholesale market where live animals, such as poultry, bats, snakes, frogs, rabbits, marmots, and hedgehogs are sold in that market which suggests a po ... | 2020 | 33363234 |
| occurrence of antibodies against sars-cov-2 in the domestic cat population of germany. | domestic cats (felis catus) are popular companion animals that live in close contact with their human owners. therefore, the risk of a trans-species spreading event between domestic cats and humans is ever-present. shortly after the emergence of the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) and its rapid spread around the world, the role of domestic cats in the transmission cycle was questioned. in the present study, the first large-scale survey of antibody occurrence in the d ... | 2020 | 33348613 |
| responses to acute infection with sars-cov-2 in the lungs of rhesus macaques, baboons and marmosets. | non-human primate models will expedite therapeutics and vaccines for coronavirus disease 2019 (covid-19) to clinical trials. here, we compare acute severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection in young and old rhesus macaques, baboons and old marmosets. macaques had clinical signs of viral infection, mild to moderate pneumonitis and extra-pulmonary pathologies, and both age groups recovered in two weeks. baboons had prolonged viral rna shedding and substantially more lu ... | 2020 | 33340034 |
| cross-species recognition of sars-cov-2 to bat ace2. | the coronavirus disease 2019 (covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has emerged as a major threat to global health. although varied sars-cov-2-related coronaviruses have been isolated from bats and sars-cov-2 may infect bat, the structural basis for sars-cov-2 to utilize the human receptor counterpart bat angiotensin-converting enzyme 2 (bace2) for virus infection remains less understood. here, we report that the sars-cov-2 spike protein recept ... | 2021 | 33335073 |
| a household case evidences shorter shedding of sars-cov-2 in naturally infected cats compared to their human owners. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has been detected in domestic and wild cats. however, little is known about natural viral infections of domestic cats, although their importance for modelling disease spread, informing strategies for managing positive human-animal relationships and disease prevention. here, we describe the sars-cov-2 infection in a household of two human adults and sibling cats (one male and two females) using real-time rt-pcr, an elisa test, viral seq ... | 2021 | 33317424 |
| the gastrointestinal tract is an alternative route for sars-cov-2 infection in a nonhuman primate model. | gastrointestinal (gi) manifestations have been increasingly reported in patients with coronavirus disease 2019 (covid-19). however, the roles of the gi tract in severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection are not fully understood. we investigated how the gi tract is involved in sars-cov-2 infection to elucidate the pathogenesis of covid-19. | 2020 | 33307034 |
| a transmissible cancer shifts from emergence to endemism in tasmanian devils. | emerging infectious diseases pose one of the greatest threats to human health and biodiversity. phylodynamics is often used to infer epidemiological parameters essential for guiding intervention strategies for human viruses such as severe acute respiratory syndrome coronavirus 2 (sars-cov-2). here, we applied phylodynamics to elucidate the epidemiological dynamics of tasmanian devil facial tumor disease (dftd), a fatal, transmissible cancer with a genome thousands of times larger than that of an ... | 2020 | 33303589 |
| novel and diverse non-rabies rhabdoviruses identified in bats with human exposure, south dakota, usa. | bats are a host and reservoir for a large number of viruses, many of which are zoonotic. in north america, the big brown bat (eptesicus fuscus) is widely distributed and common. big brown bats are a known reservoir for rabies virus, which, combined with their propensity to roost in human structures, necessitates testing for rabies virus following human exposure. the current pandemic caused by severe acute respiratory syndrome coronavirus 2, likely of bat origin, illustrates the need for continue ... | 2020 | 33302422 |
| correlates of protection against sars-cov-2 in rhesus macaques. | recent studies have reported the protective efficacy of both natural1 and vaccine-induced2-7 immunity against challenge with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) in rhesus macaques. however, the importance of humoral and cellular immunity for protection against infection with sars-cov-2 remains to be determined. here we show that the adoptive transfer of purified igg from convalescent rhesus macaques (macaca mulatta) protects naive recipient macaques against challenge wit ... | 2020 | 33276369 |
| nanoparticle vaccines based on the receptor binding domain (rbd) and heptad repeat (hr) of sars-cov-2 elicit robust protective immune responses. | various vaccine strategies have been proposed in response to the global covid-19 pandemic, each with unique strategies for eliciting immune responses. here, we developed nanoparticle vaccines by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (rbd) and/or heptad repeat (hr) subunits of the severe acute respiratory syndrome coronavirus-2 (sars-cov-2) spike (s) protein. compared to monomer vaccines, nanoparticle vaccines elicited more robust neutralizing an ... | 2020 | 33275896 |
| the roborovski dwarf hamster is a highly susceptible model for a rapid and fatal course of sars-cov-2 infection. | the coronavirus disease 2019 (covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has precipitated an unprecedented and yet-unresolved health crisis worldwide. different mammals are susceptible to sars-cov-2; however, few species examined so far develop robust clinical disease that mirrors severe human cases or allows testing of vaccines and drugs under conditions of severe disease. here, we compare the susceptibilities of three dwarf hamster species (phodop ... | 2020 | 33271063 |
| dalbavancin binds ace2 to block its interaction with sars-cov-2 spike protein and is effective in inhibiting sars-cov-2 infection in animal models. | infection with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has caused a pandemic worldwide. currently, however, no effective drug or vaccine is available to treat or prevent the resulting coronavirus disease 2019 (covid-19). here, we report our discovery of a promising anti-covid-19 drug candidate, the lipoglycopeptide antibiotic dalbavancin, based on virtual screening of the fda-approved peptide drug library combined with in vitro and in vivo functional antiviral assays. our re ... | 2020 | 33262453 |
| development of machine learning models to predict rt-pcr results for severe acute respiratory syndrome coronavirus 2 (sars-cov-2) in patients with influenza-like symptoms using only basic clinical data. | reverse transcription-polymerase chain reaction (rt-pcr) for severe acute respiratory syndrome coronavirus 2 (sars-cov-2) diagnosis currently requires quite a long time span. a quicker and more efficient diagnostic tool in emergency departments could improve management during this global crisis. our main goal was assessing the accuracy of artificial intelligence in predicting the results of rt-pcr for sars-cov-2, using basic information at hand in all emergency departments. | 2020 | 33261629 |
| a single-dose live-attenuated yf17d-vectored sars-cov-2 vaccine candidate. | the expanding pandemic of coronavirus disease 2019 (covid-19) requires the development of safe, efficacious and fast-acting vaccines. several vaccine platforms are being leveraged for a rapid emergency response1. here we describe the development of a candidate vaccine (yf-s0) for severe acute respiratory syndrome coronavirus 2 (sars-cov-2) that uses live-attenuated yellow fever 17d (yf17d) vaccine as a vector to express a noncleavable prefusion form of the sars-cov-2 spike antigen. we assess vac ... | 2020 | 33260195 |
| a highly immunogenic and effective measles virus-based th1-biased covid-19 vaccine. | the covid-19 pandemic is caused by severe acute respiratory syndrome coronavirus-2 (sars-cov-2) and has spread worldwide, with millions of cases and more than 1 million deaths to date. the gravity of the situation mandates accelerated efforts to identify safe and effective vaccines. here, we generated measles virus (mev)-based vaccine candidates expressing the sars-cov-2 spike glycoprotein (s). insertion of the full-length s protein gene in two different mev genomic positions resulted in modulat ... | 2020 | 33257540 |
| novel sars-cov-2 encoded small rnas in the passage to humans. | the severe acute respiratory syndrome-coronavirus 2 (sars-cov-2) has recently emerged as the responsible for the pandemic outbreak of the coronavirus disease 2019. this virus is closely related to coronaviruses infecting bats and malayan pangolins, species suspected to be an intermediate host in the passage to humans. several genomic mutations affecting viral proteins have been identified, contributing to the understanding of the recent animal-to-human transmission. however, the capacity of sars ... | 2021 | 33244583 |
| establishment of an african green monkey model for covid-19 and protection against re-infection. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is responsible for an unprecedented global pandemic of covid-19. animal models are urgently needed to study the pathogenesis of covid-19 and to screen vaccines and treatments. we show that african green monkeys (agms) support robust sars-cov-2 replication and develop pronounced respiratory disease, which may more accurately reflect human covid-19 cases than other nonhuman primate species. sars-cov-2 was detected in mucosal samples, inc ... | 2020 | 33235385 |
| lack of susceptibility to sars-cov-2 and mers-cov in poultry. | we challenged chickens, turkeys, ducks, quail, and geese with severe acute respiratory syndrome coronavirus 2 or middle east respiratory syndrome coronavirus. we observed no disease and detected no virus replication and no serum antibodies. we concluded that poultry are unlikely to serve a role in maintenance of either virus. | 2020 | 33219803 |
| detection and characterization of bat sarbecovirus phylogenetically related to sars-cov-2, japan. | epidemiology of bat betacoronavirus, subgenus sarbecovirus is largely unknown, especially outside china. we detected a sarbecovirus phylogenetically related to severe acute respiratory syndrome coronavirus 2 from rhinolophus cornutus bats in japan. the sarbecovirus' spike protein specifically recognizes angiotensin-converting enzyme 2 of r. cornutus, but not humans, as an entry receptor. | 2020 | 33219796 |
| coinfection by severe acute respiratory syndrome coronavirus 2 and influenza a(h1n1)pdm09 virus enhances the severity of pneumonia in golden syrian hamsters. | clinical outcomes of the interaction between the co-circulating pandemic severe acute respiratory syndrome coronavirus 2 (sars-cov-2) and seasonal influenza viruses are unknown. | 2021 | 33216851 |
| sars-cov-2 transmission between mink (neovison vison) and humans, denmark. | severe acute respiratory syndrome coronavirus 2 has caused a pandemic in humans. farmed mink (neovison vison) are also susceptible. in denmark, this virus has spread rapidly among farmed mink, resulting in some respiratory disease. full-length virus genome sequencing revealed novel virus variants in mink. these variants subsequently appeared within the local human community. | 2020 | 33207152 |
| severe acute respiratory syndrome coronavirus-2 natural animal reservoirs and experimental models: systematic review. | the current severe acute respiratory syndrome coronavirus-2 (sars-cov-2) outbreak has been rapidly spreading worldwide, causing serious global concern. the role that animal hosts play in disease transmission is still understudied and researchers wish to find suitable animal models for fundamental research and drug discovery. in this systematic review, we aimed to compile and discuss all articles that describe experimental or natural infections with sars-cov-2, from the initial discovery of the v ... | 2020 | 33206434 |
| zika virus and host interactions: from the bench to the bedside and beyond. | before the emergence of sars-cov-2 (severe acute respiratory syndrome coronavirus 2), the causative agent of the current covid-19 (coronavirus disease 2019) pandemic [...]. | 2020 | 33198165 |
| sars-cov-2: a critical review of its history, pathogenesis, transmission, diagnosis and treatment. | the outbreak of the deadly virus (novel coronavirus or severe acute respiratory syndrome coronavirus-2) that emerged in december 2019, remained a controversial subject of intense speculations regarding its origin, became a worldwide health problem resulting in serious coronavirus disease 2019 (acronym covid-19). the concern regarding this new viral strain severe acute respiratory syndrome coronavirus-2 (acronym sars-cov-2) and diseases it causes (covid-19) is well deserved at all levels. the inc ... | 2020 | 33196035 |
| predicting the animal susceptibility and therapeutic drugs to sars-cov-2 based on spike glycoprotein combined with ace2. | recently, a few animals have been frequently reported to have been diagnosed with severe acute respiratory syndrome coronavirus 2 (sars-cov-2). whether they are sars-cov-2 intermediate hosts is worthy of great attention. the interaction of sars-cov-2 spike protein and its acceptor protein ace2 is an important issue in determining viral host range and cross-species infection, while the binding capacity of spike protein to ace2 of different species is unknown. here, we used the atomic structure mo ... | 2020 | 33193684 |
| multi-species elisa for the detection of antibodies against sars-cov-2 in animals. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has caused a pandemic with millions of infected humans and hundreds of thousands of fatalities. as the novel disease - referred to as covid-19 - unfolded, occasional anthropozoonotic infections of animals by owners or caretakers were reported in dogs, felid species and farmed mink. further species were shown to be susceptible under experimental conditions. the extent of natural infections of animals, however, is still largely unknown. ... | 2020 | 33191578 |
| comparative analysis of sars-cov-2 and its receptor ace2 with evolutionarily related coronaviruses. | the pandemic covid-19 is caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) and it is spreading very rapidly worldwide. to date, the origin and intermediate hosts of sars-cov-2 remain unclear. in this study, we conducted comparative analysis among sars-cov-2 and non-sars-cov-2 coronavirus strains to elucidate their phylogenetic relationships. we found: 1, the sars-cov-2 strains analyzed could be divided into 3 clades with regional aggregation; 2, the non-sars-cov-2 common ... | 2020 | 33186121 |
| sars-cov-2 d614g variant exhibits efficient replication ex vivo and transmission in vivo. | the spike aspartic acid-614 to glycine (d614g) substitution is prevalent in global severe acute respiratory syndrome coronavirus 2 (sars-cov-2) strains, but its effects on viral pathogenesis and transmissibility remain unclear. we engineered a sars-cov-2 variant containing this substitution. the variant exhibits more efficient infection, replication, and competitive fitness in primary human airway epithelial cells but maintains similar morphology and in vitro neutralization properties, compared ... | 2020 | 33184236 |
| acute respiratory distress in aged, sars-cov-2 infected african green monkeys but not rhesus macaques. | sars-cov-2 induces a wide range of disease severity ranging from asymptomatic infection, to a life-threating illness, particularly in the elderly and persons with comorbid conditions. among those persons with serious covid-19 disease, acute respiratory distress syndrome (ards) is a common and often fatal presentation. animal models of sars-cov-2 infection that manifest severe disease are needed to investigate the pathogenesis of covid-19 induced ards and evaluate therapeutic strategies. here we ... | 2020 | 33171111 |
| covid-19 from wellington new zealand. | this paper examines the role of bioethics in the successful control of covid-19 in new zealand. after the severe acute respiratory syndrome (sars) coronavirus episode in toronto researchers developed a framework of values and principles to articulate values that were already commonly accepted "in the community of its intended users," to be used to inform decision-making. new zealand subsequently developed its own framework that was embedded in its pandemic influenza plan. these formed the basis ... | 2020 | 33169244 |
| the progression of sars coronavirus 2 (sars-cov2): mutation in the receptor binding domain of spike gene. | severe acute respiratory syndrome coronavirus 2 (sars-cov2) is a positive-sense single-stranded rna (+ssrna) that causes coronavirus disease 2019 (covid-19). the viral genome encodes twelve genes for viral replication and infection. the third open reading frame is the spike (s) gene that encodes for the spike glycoprotein interacting with specific cell surface receptor - angiotensin converting enzyme 2 (ace2) - on the host cell membrane. most recent studies identified a single point mutation in ... | 2020 | 33163249 |
| de novo design of potent and resilient hace2 decoys to neutralize sars-cov-2. | we developed a de novo protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracellular host proteins to infect the cell. our pipeline allowed the design, validation, and optimization of de novo hace2 decoys to neutralize sars-cov-2. the best decoy, ctc-445.2, binds with low nanomolar affinity and high specificity to the rbd of the spike protein. cryo-em shows that the design is accurate and can simultaneously bind to all three rbds of a single spike prote ... | 2020 | 33154107 |
| impact of covid-19 on maternal and neonatal outcomes: a systematic review and meta-analysis. | previous outbreaks of severe acute respiratory syndrome coronavirus 1 (sars-cov-1) and middle east respiratory syndrome coronavirus (mers-cov) have been associated with unfavourable pregnancy outcomes. sars-cov-2 belongs to the human coronavirus family, and since this infection shows a pandemic trend it will involve many pregnant women. | 2020 | 33148440 |
| ace2 and ace: structure-based insights into mechanism, regulation and receptor recognition by sars-cov. | angiotensin converting enzyme (ace) is well-known for its role in blood pressure regulation via the renin-angiotensin aldosterone system (raas) but also functions in fertility, immunity, haematopoiesis and diseases such as obesity, fibrosis and alzheimer's dementia. like ace, the human homologue ace2 is also involved in blood pressure regulation and cleaves a range of substrates involved in different physiological processes. importantly, it is the functional receptor for severe acute respiratory ... | 2020 | 33146371 |
| serological evidence of exposure to a coronavirus antigenically related to severe acute respiratory syndrome virus (sars-cov-1) in the grey-headed flying fox (pteropus poliocephalus). | many infectious pathogens can be transmitted by highly mobile species, like bats that can act as reservoir hosts for viruses such as henipaviruses, lyssaviruses and coronaviruses. in this study, we investigated the seroepidemiology of protein antigens to severe acute respiratory syndrome virus (sars-cov-1) and middle eastern respiratory syndrome virus (mers-cov) in grey-headed flying foxes (pteropus poliocephalus) in adelaide, australia sampled between september 2015 and february 2018. a total o ... | 2020 | 33142031 |
| the value of the platelet count and platelet indices in differentiation of covid-19 and influenza pneumonia. | it is difficult to distinguish coronavirus disease-2019 (covid-19) from other viral respiratory tract infections owing to the similarities in clinical and radiological findings. this study aims to determine the clinical importance of platelet count and platelet indices in the differentiation of covid-19 from influenza and the value of these parameters in the differential diagnosis of covid-19. the medical records of the patients and the electronic patient monitoring system were retrospectively a ... | 2020 | 33135801 |
| dentistry and covid-19 pandemic: operative indications post-lockdown. | a new coronavirus, the seventh member of the coronaviridae family, identified as sars-cov-2, spread in late december 2019 in the territory of wuhan in china. cov-2019 can be transmitted directly from person to person by respiratory drops, direct contact and contaminated material. furthermore, 2019-ncov penetrates cells similarly to the sars coronavirus, i.e., through the ace2 receptor. this may promote human-to-human transmission. patients and dental professionals are exposed daily to pathogenic ... | 2020 | 33135082 |
| generation of chicken igy against sars-cov-2 spike protein and epitope mapping. | this new decade has started with a global pandemic of covid-19 caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2), precipitating a worldwide health crisis and economic downturn. scientists and clinicians have been racing against time to find therapies for covid-19. repurposing approved drugs, developing vaccines and employing passive immunization are three major therapeutic approaches to fighting covid-19. chicken immunoglobulin y (igy) has the potential to be used as neutral ... | 2020 | 33134398 |
| practice implications for acute ischemic stroke during the covid-19 pandemic for the indian scenario: realistic and achievable recommendations by the society of neurocritical care (sncc), india. | covid-19 disease caused by the sars coronavirus has caused significant morbidity and mortality around the world ever since it was first declared as a pandemic by the world health organization (who) in march 2020. acute neurological manifestations of this disease have also started emerging and being recognized around the world and acute ischemic stroke (ais) or thrombotic stroke is becoming one of the major neurological illnesses related to covid-19. the management of ais is time-critical and maj ... | 2020 | 33132556 |
| diagnostic salivary tests for sars-cov-2. | the diagnosis of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection relies on the detection of viral rna by real-time reverse transcription polymerase chain reaction (rrt-pcr) performed with respiratory specimens, especially nasopharyngeal swabs. however, this procedure requires specialized medical personnel, centralized laboratory facilities, and time to provide results (from several hours up to 1 d). in addition, there is a non-negligible risk of viral transmission for the ... | 2020 | 33131360 |
| production of trimeric sars-cov-2 spike protein by cho cells for serological covid-19 testing. | we describe scalable and cost-efficient production of full length, his-tagged severe acute respiratory syndrome coronavirus 2 (sars-cov-2) spike glycoprotein trimer by chinese hamster ovary (cho) cells that can be used to detect sars-cov-2 antibodies in patient sera at high specificity and sensitivity. transient production of spike in both human embryonic kidney (hek) and cho cells mediated by polyethyleneimine was increased significantly (up to 10.9-fold) by a reduction in culture temperature t ... | 2020 | 33128388 |
| impact of the coronavirus disease-19 pandemic on acute cardiovascular emergencies in a third level cardiology hospital: a call for action. | the consequences of the coronavirus disease (covid)-19 pandemic go beyond the number of cases and deaths attributed to severe acute respiratory syndrome (sars)-coronavirus-2 infection. the overwhelmed health care systems and the strict social containment measures have had an impact on the threshold at which patients seek medical care for diseases other than covid-19, including cardiovascular conditions. | 2020 | 33120401 |
| experience repatriation of citizens from epicentre using commercial flights during covid-19 pandemic. | during the covid-19 pandemic, many countries instituted closure of borders from international and local travels. stranded citizens appeal to their governments to embark on citizen repatriation missions. between february and april 2020, the government of malaysia directed repatriation of its citizens from china, iran, italy and indonesia. we describe the preparation and execution of the repatriation mission using chartered commercial aircraft. the mission objectives were to repatriate as many cit ... | 2020 | 33115412 |
| covid-19 spread in saudi arabia: modeling, simulation and analysis. | the novel coronavirus severe acute respiratory syndrome (sars)-coronavirus-2 (cov-2) has resulted in an ongoing pandemic and has affected over 200 countries around the world. mathematical epidemic models can be used to predict the course of an epidemic and develop methods for controlling it. as social contact is a key factor in disease spreading, modeling epidemics on contact networks has been increasingly used. in this work, we propose a simulation model for the spread of coronavirus disease 20 ... | 2020 | 33113936 |
| perspectives for the use of n-acetylcysteine as a candidate drug to treat covid-19. | coronavirus disease 2019 (covid-19) caused by severe acute respiratory syndrome-related coronavirus-2 (sars-cov-2) has become an ongoing pandemic worldwide. however, there are no vaccines or antiviral drugs with proven clinical efficacy. therefore, a remedial measure is urgently needed to combat with the devastating covid-19. the pharmacological activities of n-acetylcysteine (nac) and its potential functions in inhibiting the progression of covid19 make it a promising therapeutic agent in covid ... | 2020 | 33109047 |
| an unusual inflammatory disease linked to sars coronavirus-2 in children: are we prepared enough? | 2020 | 33107277 | |
| mitraclip insertion to hasten recovery from severe covid-19 disease. | •coronavirus disease 2019 (covid-19) caused by severe acute respiratory syndrome (sars) coronavirus 2 has affected 188 countries worldwide with a global death toll of over half a million•patients with valvular heart disease are also at an increased risk of adverse outcomes from coronavirus disease-2019•prognosis of patients with the combination of covid 19 and severe valvular heart disease is poor•this is the first reported case of mitraclip insertion in a patient with severe covid 19 infection. ... | 2020 | 33103013 |
| covid-19 in human, animal, and environment: a review. | the medical authority in china, especially in wuhan city, reported on december 2019 a large number of highly fatal, rapidly spreading viral pneumonia caused by an unknown coronavirus. the common history of all the patients was their visiting a wuhan's whole food store, where live animals and seafood are sold. irrespective of the efforts of the chinese authorities, the virus spread rapidly all over the world by travelers, provoking widespread attention by the media and panic. many previous corona ... | 2020 | 33102545 |
| anesthesia for oral surgeries during the covid-19 pandemic. | the severe acute respiratory syndrome corona virus 2(sars-cov2) virus replicates in the nasal cavity, nasopharynx, and the oropharynx. during oral surgery, the risk of viral transmission is high during instrumentation in these areas, while performing airway management procedures, the oral surgery itself, and related procedures. during the corona virus disease 2019 (covid-19) pandemic, patients with an oral pathology usually present for emergency procedures. however, patients with oral cancer, be ... | 2020 | 33100656 |
| acute myelitis and sars-cov-2 infection. a new etiology of myelitis? | the etiological agent of coronavirus disease-19 (covid-19), sars-coronavirus-2 (sars-cov-2), emerged in wuhan, china, and quickly spread worldwide leading the world health organization (who) to recognize it not only as a pandemic but also as an important thread to public health. beyond respiratory symptoms, new neurological manifestations are being identified such as headache, ageusia, anosmia, encephalitis or acute cerebrovascular disease. here we report the case of an acute transverse myelitis ... | 2020 | 33099361 |
| severe acute respiratory distress syndrome secondary to coronavirus 2 (sars-cov-2). | the novel severe acute respiratory syndrome coronavirus 2 (sars-cov-2) causes coronavirus disease 2019 (covid-19) and has created a worldwide pandemic. many patients with this infection have an asymptomatic or mild illness, but a small percentage of patients require hospitalization and intensive care. patients with respiratory tract involvement have a spectrum of presentations that range from scattered ground-glass infiltrates to diffuse infiltrates with consolidation. patients with the latter r ... | 2020 | 33098401 |
| utility of proteomics in emerging and re-emerging infectious diseases caused by rna viruses. | emerging and re-emerging infectious diseases due to rna viruses cause major negative consequences for the quality of life, public health, and overall economic development. most of the rna viruses causing illnesses in humans are of zoonotic origin. zoonotic viruses can directly be transferred from animals to humans through adaptation, followed by human-to-human transmission, such as in human immunodeficiency virus (hiv), severe acute respiratory syndrome coronavirus (sars-cov), middle east respir ... | 2020 | 33095583 |
| susceptibility of raccoon dogs for experimental sars-cov-2 infection. | raccoon dogs might have been intermediate hosts for severe acute respiratory syndrome-associated coronavirus in 2002-2004. we demonstrated susceptibility of raccoon dogs to severe acute respiratory syndrome coronavirus 2 infection and transmission to in-contact animals. infected animals had no signs of illness. virus replication and tissue lesions occurred in the nasal conchae. | 2020 | 33089771 |
| engineering a model to study viral infections: bioprinting, microfluidics, and organoids to defeat coronavirus disease 2019 (covid-19). | while the number of studies related to severe acute respiratory syndrome-related coronavirus 2 (sars-cov-2) is constantly growing, it is essential to provide a framework of modeling viral infections. therefore, this review aims to describe the background presented by earlier used models for viral studies and an approach to design an "ideal" tissue model for sars-cov-2 infection. due to the previous successful achievements in antiviral research and tissue engineering, combining the emerging techn ... | 2020 | 33089000 |
| deep mutagenesis in the study of covid-19: a technical overview for the proteomics community. | the spike (s) of sars coronavirus 2 (sars-cov-2) engages angiotensin-converting enzyme 2 (ace2) on a host cell to trigger viral-cell membrane fusion and infection. the extracellular region of ace2 can be administered as a soluble decoy to compete for binding sites on the receptor-binding domain (rbd) of s, but it has only moderate affinity and efficacy. the rbd, which is targeted by neutralizing antibodies, may also change and adapt through mutation as sars-cov-2 becomes endemic, posing challeng ... | 2020 | 33084449 |
| associations between genetically predicted protein levels and covid-19 severity. | it is critical to identify potential causal targets for sars-coronavirus 2, which may guide drug repurposing options. we assessed the associations between genetically predicted protein levels and covid-19 severity. leveraging data from the covid-19 host genetics initiative comparing 6,492 hospitalized covid-19 patients and 1,012,809 controls, we identified 18 proteins with genetically predicted levels to be associated with covid-19 severity at a false discovery rate of <0.05, including 12 that s ... | 2020 | 33083826 |
| sars-cov-2 testing for asymptomatic adult cancer patients before initiating systemic treatments: a systematic review. | cancer patients may have a higher risk of severe events and unfavourable outcomes in the setting of covid-19. this review addresses the question of whether to test asymptomatic cancer patients before initiating systemic cancer treatments. | 2020 | 33082850 |
| acute aorto-iliac occlusion in patient with covid-19. | coronavirus (sars-coronavirus-2:sars-cov-2) pandemic is affecting almost every country in the world. even if the major symptoms of coronavirus disease-2019 (covid-19) are respiratory, different symptoms at presentation are now recognized. venous thromboembolism has been reported in infected patients and few but increasing cases of arterial thrombosis have been described. we report a case of acute aorto-iliac and lower limb artery occlusions in a patient presenting with severe covid-19 infection. ... | 2020 | 33075454 |
| kinetics and isotype assessment of antibodies targeting the spike protein receptor-binding domain of severe acute respiratory syndrome-coronavirus-2 in covid-19 patients as a function of age, biological sex and disease severity. | there is an incomplete understanding of the host humoral immune response to severe acute respiratory syndrome (sars)-coronavirus (cov)-2, which underlies covid-19, during acute infection. host factors such as age and sex as well as the kinetics and functionality of antibody responses are important factors to consider as vaccine development proceeds. the receptor-binding domain of the cov spike (rbd-s) protein mediates host cell binding and infection and is a major target for vaccine design to el ... | 2020 | 33072323 |
| anti-covid-19 terpenoid from marine sources: a docking, admet and molecular dynamics study. | traditional medicines contain natural products (nps) as main ingredient which always give new direction and paths to develop new advanced medicines. in the covid-19 pandemic, nps can be used or can help to find new compound against it. the sars coronavirus-2 main protease (sars cov-2 mpro) enzyme, arbitrate viral replication and transcription, is target here. the study show that, from the electronic features and binding affinity of all the nps with the enzyme, the compounds with higher hydrophob ... | 2020 | 33071352 |
| the role of dysregulated immune responses in covid-19 pathogenesis. | the coronavirus disease-2019 (covid-19) which caused by severe acute respiratory syndrome-related coronavirus (sars-cov-2), is a pandemic threat to global public health. it has a wide spectrum of clinical manifestations from mild to critical illness, the most serious of which is the complications of acute respiratory distress syndrome (ards). sars-cov-2 infection appears mild in infants and children, however, in adults, it can lead to serious consequences. in this review, we highlighted the diff ... | 2020 | 33069815 |
| the use of copper to help prevent transmission of sars-coronavirus and influenza viruses. a general review. | the sars-cov-2 is the causative agent of the covid-19 disease, a severe acute respiratory syndrome-coronavirus (sars-cov). its main transmission pathway is through large respiratory droplets, as well as direct and indirect contact. copper in different formats has been used in research and clinical settings to reduce the risk of bacterial and viral contamination. therefore, this review aims to search for evidence about the biocidal properties of copper over the coronaviridae family. a literature ... | 2020 | 33069048 |
| is there a link between bisphenol a (bpa), a key endocrine disruptor, and the risk for sars-cov-2 infection and severe covid-19? | infection by the severe acute respiratory syndrome (sars) coronavirus-2 (sars-cov-2) is the causative agent of a new disease (covid-19). the risk of severe covid-19 is increased by certain underlying comorbidities, including asthma, cancer, cardiovascular disease, hypertension, diabetes, and obesity. notably, exposure to hormonally active chemicals called endocrine-disrupting chemicals (edcs) can promote such cardio-metabolic diseases, endocrine-related cancers, and immune system dysregulation a ... | 2020 | 33066495 |
| pharmacological insight into potential therapeutic agents for the deadly covid-19 pandemic. | coronaviruses are pleomorphic, enveloped, or spherical viruses, which have a size ranging from 80 to 120 nm. these viruses act on receptors that cause the triggering of fusion. coronaviruses were first described after cultivation from patients with common colds by tyrell and bynoe in 1966. there are various subtypes of coronavirus, 7 out of these can cause infection in human beings. the alpha subtype is responsible for mild infection showing symptoms or infection without any prevailing symptoms. ... | 2020 | 33065092 |
| discovery of ketone-based covalent inhibitors of coronavirus 3cl proteases for the potential therapeutic treatment of covid-19. | the novel coronavirus disease covid-19 that emerged in 2019 is caused by the virus sars cov-2 and named for its close genetic similarity to sars cov-1 that caused severe acute respiratory syndrome (sars) in 2002. both sars coronavirus genomes encode two overlapping large polyproteins, which are cleaved at specific sites by a 3c-like cysteine protease (3clpro) in a post-translational processing step that is critical for coronavirus replication. the 3clpro sequences for cov-1 and cov-2 viruses are ... | 2020 | 33054210 |
| high rates of pulmonary artery occlusions in covid-19. a meta-analysis. | covid-19 patients are considered at high risk of venous thromboembolism (vte). the real nature of pulmonary artery occlusions (pao) in covid-19 has been questioned, suggesting that it is caused also by in situ thrombi, rather than only by emboli (pe) from peripheral thrombi. | 2020 | 33053206 |
| single-dose intranasal administration of adcovid elicits systemic and mucosal immunity against sars-cov-2 in mice. | the coronavirus disease 2019 (covid-19) pandemic has highlighted the urgent need for effective preventive vaccination to reduce burden and spread of severe acute respiratory syndrome (sars) coronavirus 2 (sars-cov-2) in humans. intranasal vaccination is an attractive strategy to prevent covid-19 as the nasal mucosa represents the first-line barrier to sars-cov-2 entry before viral spread to the lung. although sars-cov-2 vaccine development is rapidly progressing, the current intramuscular vaccin ... | 2020 | 33052351 |
| from people to panthera: natural sars-cov-2 infection in tigers and lions at the bronx zoo. | despite numerous barriers to transmission, zoonoses are the major cause of emerging infectious diseases in humans. among these, severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers), and ebolaviruses have killed thousands; the human immunodeficiency virus (hiv) has killed millions. zoonoses and human-to-animal cross-species transmission are driven by human actions and have important management, conservation, and public health implications. the current sars-cov-2 pande ... | 2020 | 33051368 |
| analysis of sars-cov-2 mutations in mexico, belize, and isolated regions of guatemala and its implication in the diagnosis. | the genomic sequences of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) worldwide are publicly available and are derived from studies due to the increase in the number of cases. the importance of study of mutations is related to the possible virulence and diagnosis of sars-cov-2. to identify circulating mutations present in sars-cov-2 genomic sequences in mexico, belize, and guatemala to find out if the same strain spread to the south, and analyze the specificity of the primers use ... | 2020 | 33049069 |
| [initial experience in the attention of patients with covid-19 in a private third-level hospital in buenos aires city]. | infection with the sars coronavirus type 2 (covid-19) has a variety of presentations, with little data on the evolution of affected patients in argentina. this is a retrospective and observational study of patients with virological confirmation of coronavirus treated during the months of march to may in a private third-level university hospital in buenos aires. o ne hundred and fifty-five adult patients were included, of which 30.3% attended only for a swab; 59.4% were admitted to the hospital a ... | 2020 | 33048785 |
| detected sars-cov-2 in ascitic fluid followed by cryptococcemia: a case report. | sars coronavirus-2 (sars-cov-2) detection in different clinical specimens has raised important insights about its pathogenesis, but some details remain to be understood. in that respect, disrupt viral control seen in solid organ transplant patients on chronic immunosuppression can help unveil pathogenic mechanisms and characterize new coronavirus disease-19 (covid-19) immunological and clinical aspects, as well as secondary complications. we herein report a case of sars-cov-2 detection in asciti ... | 2020 | 33047097 |
| covid-19 respiratory support in the emergency department setting. | severe acute respiratory syndrome-related coronavirus 2 (sars-cov-2), which causes the coronavirus disease 2019 (covid-19), may result in severe complications, multiorgan dysfunction, acute respiratory failure, and death. sars-cov-2 is highly contagious and places healthcare workers at significant risk, especially during aerosol-generating procedures, including airway management. | 2020 | 33046288 |
| insights on sars-cov-2 molecular interactions with the renin-angiotensin system. | the emergence of sars-cov-2/human/wuhan/x1/2019, a virus belonging to the species severe acute respiratory syndrome-related coronavirus, and the recognition of coronavirus disease 2019 (covid-19) as a pandemic have highly increased the scientific research regarding the pathogenesis of covid-19. the renin angiotensin system (ras) seems to be involved in covid-19 natural course, since studies suggest the membrane-bound angiotensin-converting enzyme 2 (ace2) works as sars-cov-2 cellular receptor. b ... | 2020 | 33042994 |
| 2019-ncov may create complications in colon cancer patients with ace2 expression. | since december 2019, a novel coronavirus (2019-ncov) has emerged from wuhan, china, causing symptoms in humans. much remains unknown about 2019-ncov, especially the additional risks that 2019-ncov infection may pose for colon cancer patients. many reports show that angiotensin converting enzyme ii (ace2) is the cell receptor through which 2019-ncov enters host cells, and this is similar to the cell entry mechanism of sars coronavirus. previous studies show that ace2 is highly expressed in the ga ... | 2020 | 33042335 |
| the important role of in-situ simulation in preparing surgeons for the covid-19 pandemic. | effective training is vital when facing viral outbreaks such as the sars coronavirus 2 (sars-cov-2) outbreak of 2019. the objective of this study was to measure the impact of in-situ simulation on the confidence of the surgical teams of two hospitals in assessing and managing acutely unwell surgical patients who are high-risk or confirmed to have covid-19. | 2020 | 33039335 |