Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [effect of water extracts from rhizosphere soil of cultivated astragalus membranaceus var. mongholicus on it's seed germination and physiological characteristics]. | to explore the relationship between continuous cropping obstacle and autotoxicity of astragalus membranaceus var. mongholicus. | 2015 | 26214865 |
| [correlation between chemical constituents and ecological factors of astragalus membranaceus var. mongholicus]. | principal component analysis (pca) and correlation analysis (ca) were applied to analyze the correlation of the main chemical components in astragalus membranaceus var. mongholicus and ecological factors. the results showed that the contents of astragaloside, campanulin, ononin, kaempferol and astragalus polysaccharides (aps) of a. membranaceus var. mongholicus produced. in shanxi were significantly higher than in inner mongolia and gansu. the main climatic factors for affecting the contents of ... | 2015 | 26211053 |
| decoding glycome of astragalus membranaceus based on pressurized liquid extraction, microwave-assisted hydrolysis and chromatographic analysis. | carbohydrates in herbs are a relatively untapped source of new drugs and health beneficial ingredients. their analysis has been developed as a novel aspect in quality control and herbal glycomics. in this study, glycome of astragalus membranaceus was decoded based on optimized pressurized liquid extraction (ple), microwave-assisted acidic hydrolysis (maah) and comprehensive chromatographic approaches. twelve saccharides including sucrose, galacturonic acid, mannitol, fructose, rhamnose, ribose, ... | 2015 | 26209192 |
| guiqi polysaccharide protects the normal human fetal lung fibroblast wi-38 cells from h2o2-induced premature senescence. | this study is to investigate the effects of guiqi polysaccharide (gqp) on h2o2-induced premature senescence in normal human fetal lung fibroblast wi-38 cells. | 2015 | 26191131 |
| an open label clinical trial of a multi-ingredient anti-aging moisturizer designed to improve the appearance of facial skin. | an open label clinical trial was conducted to determine the effectiveness of a multi-ingredient anti-aging moisturizer designed to improve the appearance of facial skin. parameters studied included fine lines and wrinkles, clarity/brightness, visual roughness, tactile roughness, evenness of skin tone (redness), evenness of skin tone (hyperpigmentation) and overall appearance. thirty-seven female subjects, ages 35-60 years completed the study. effective ingredients incorporated into the facial an ... | 2015 | 26151786 |
| effect of shenkang granules on the progression of chronic renal failure in 5/6 nephrectomized rats. | shenkang granules (skgs) are a chinese herbal medicinal formula, consisting of rhubarb (rheum palmatum l.), salvia miltiorrhiza, milkvetch root [astragalus membranaceus (fisch.) bunge] and safflower (carthamus tinctorius l.). the aim of the present study was to investigate the effect of skg on chronic renal failure (crf) in 5/6 nephrectomized (5/6 nx) rats. the rats were randomly divided into seven groups (n=10 per group) as follows: (i) 5/6 nx (model group; 2.25 ml/kg/day normal saline); (ii) s ... | 2015 | 26136932 |
| fyn arrests swainsonine-induced apoptosis in 293t cells via akt and its phosphorylation. | swainsonine (sw), an extract from astragalus membranaceus, represents a new class of compounds that inhibit growth and induce apoptosis in a cancer model. in this study, we demonstrated the effect of fyn on sw-induced apoptosis in 293t cells. western blotting was used to measure the expression of the apoptosis-related factors caspase-3, bcl-2, bax, and the key factor akt (also known as protein kinase b). apoptosis increased dramatically after treatment with sw. unlike the control group, after tr ... | 2015 | 26125726 |
| global transcriptome analysis profiles metabolic pathways in traditional herb astragalus membranaceus bge. var. mongolicus (bge.) hsiao. | astragalus membranaceus bge. var. mongolicus (bge.) hsiao (a. mongolicus, family leguminosae) is one of the most important traditional chinese herbs. among many secondary metabolites it produces, the effective bioactive constituents include isoflavonoids and triterpene saponins. the genomic resources regarding the biosynthesis of these metabolites in a. mongolicus are limited. although roots are the primary material harvested for medical use, the biosynthesis of the bioactive compounds and its r ... | 2015 | 26099797 |
| tetracyclic triterpenoids in herbal medicines and their activities in diabetes and its complications. | tetracyclic triterpenoids, including the dammarane, cucurbitane, cycloartane, lanostane and protostane groups, is a class of triterpenoids widely distributed in various medicinal plants, particularly those commonly used for the treatment of diabetes and its complications, such as panax ginseng, panax quinquefolium, panax notoginseng, gynostemma pentaphyllum, astragalus membranaceus, momordica charantia, and ganoderma lucidum. this review highlights recent findings on the chemistry and bioactivit ... | 2015 | 26088353 |
| [inhibiting effects of three components of astragalus membranaceus on oxidative stress in chang liver cells]. | the main objective of this research is to investigate the effects of astragaloside iv, calycosin separately glucoside, formononetin on oxidative stress in chang liver cells induced by h2o2. in the experiments, chang liver cells (a kind of normal human hepatocytes) were used as the research object, bifendate which has a clear hepatoprotective effect was used as the positive control drug, then the oxidative damage model of chang liver cells were established by h2o2. cells were divided into six gro ... | 2015 | 26080566 |
| effects of astragaloside iv on the sdf-1/cxcr4 expression in atherosclerosis of apoe(-/-) mice induced by hyperlipaemia. | astragaloside iv (asiv) is the major effective component extracted from the chinese herb astragalus membranaceus, which has been widely used to treat cardiovascular disease. recent studies have shown that asiv can potentially protect the arteries from atherosclerosis; however the mechanisms underneath are unknown. the aim of this study was to investigate the effects of asiv on blood lipids, cd40-cd40l signal system, and sdf-1/cxcr4 biological axis in high-fat diet apoe(-/-) mice and reveal the m ... | 2015 | 26074989 |
| transcriptional profiling and molecular characterization of astragalosides, calycosin, and calycosin-7-o-β-d-glucoside biosynthesis in the hairy roots of astragalus membranaceus in response to methyl jasmonate. | we used the next-generation illumina/solexa hiseq2000 platform on rna analysis to investigate the transcriptome of astragalus membranaceus hairy roots in response to 100 μm methyl jasmonate (meja). in total, 77,758,230 clean reads were assembled into 48,636 transcripts (average length of 1398 bp), which were clustered into 23,658 loci (genes). of these, 19,940 genes were annotated by blastx searches. in addition, deseq analysis showed that 2127 genes were up-regulated, while 1247 genes were down ... | 2015 | 26072674 |
| combination efficacy of astragalus membranaceus and curcuma wenyujin at different stages of tumor progression in an imageable orthotopic nude mouse model of metastatic human ovarian cancer expressing red fluorescent protein. | the present study determined the efficacy of extracts of astragalus membranaceus (am) and curcuma wenyujin (cw), a traditional chinese medicine herbal mixture, at different tumor stages of an orthotopic nude mouse model of human ovarian cancer expressing red fluorescent protein. | 2015 | 26026079 |
| astragaloside iv attenuates glutamate-induced neurotoxicity in pc12 cells through raf-mek-erk pathway. | astragaloside iv (ags-iv) is a main active ingredient of astragalus membranaceus bunge, a medicinal herb prescribed as an immunostimulant, hepatoprotective, antiperspirant, a diuretic or a tonic as documented in chinese materia medica. in the present study, we employed a high-throughput comparative proteomic approach based on 2d-nano-lc-ms/ms to investigate the possible mechanism of action involved in the neuroprotective effect of ags-iv against glutamate-induced neurotoxicity in pc12 cells. dif ... | 2015 | 25961569 |
| astragaloside iv inhibits nf- κ b activation and inflammatory gene expression in lps-treated mice. | in this study we investigated the role of astragaloside iv (as-iv), one of the major active constituents purified from the chinese medicinal herb astragalus membranaceus, in lps-induced acute inflammatory responses in mice in vivo and examined possible underlying mechanisms. mice were assigned to four groups: vehicle-treated control animals; as-iv-treated animals (10 mg/kg b.w. as-iv daily i.p. injection for 6 days); lps-treated animals; and as-iv plus lps-treated animals. we found that as-iv tr ... | 2015 | 25960613 |
| compound astragalus and salvia miltiorrhiza extracts modulate mapk-regulated tgf-β/smad signaling in hepatocellular carcinoma by multi-target mechanism. | astragalus membranaceus bunge (leguminosae) and salvia miltiorrhiza bunge (lamiaceae) are two important chinese herbs with a long history of extensive ethnobotanical usage in the treatment of liver-related diseases over many centuries. presently, these two herbs are being used either as a single herbal formulation or a composite formula for the treatment of liver related conditions. in response, recent studies on these two herbs have focused on elucidating their mechanisms of action, particularl ... | 2015 | 25934513 |
| astragaloside iv and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated txnip/nlrp3 inflammasome activation in the endothelium. | astragaloside iv and cycloastragenol are present together in astragalus membranaceus moench (fabaceae) and this study aims to simultaneously investigate their regulation of endothelial homeostasis in the setting of endoplasmic reticulum stress (er stress). | 2015 | 25922268 |
| electrophysiological effect and the gating mechanism of astragaloside iv on l-type ca(2+) channels of guinea-pig ventricular myocytes. | astragaloside iv (as-iv) is one of the main active ingredients of astragalus membranaceus. this study is aimed to investigate as-iv׳s effects on ca(2+) channel activity of single cardiomyocytes and single ca(2+) channels. whole-cell ca(2+) currents in freshly dissociated cardiomyocytes were measured using the whole-cell patch-clamp technique. single ca(2+) channel currents were examined in cell-attached patches and inside-out patches. in the whole-cell recording, as-iv reduced the amplitude of l ... | 2015 | 25891370 |
| nitric oxide inhibitory flavonoids from traditional chinese medicine formula baoyuan decoction. | three new flavonoid glycosides, (3r)-(+)-isomucronulatol-2'-o-β-d-glucopyranoside (1), (3r)-(-)-isomucronulatol-7-o-β-d-apiofuranosyl(1→2)-β-d-glucopyranoside (2), and (2s)-(-)-7,8-dihydroxylflavanone-4'-o-β-d-apiofuranosyl(1→2)-β-d-glucopyranoside (3), along with eight flavanones (4, 8, 10, 12, 15, 16, 21, and 24), four isoflavones (5, 11, 13, and 23), four chalcones (6, 14, 17, and 18), two isoflavans (19-20), one flavone (7), one flavonol (9), and one dihydrochalcone (22) were isolated from b ... | 2015 | 25889071 |
| astragaloside iv attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress. | diabetic nephropathy (dn) is a major cause of chronic kidney disease and end-stage renal disease throughout the world; however, the reversibility of diabetic nephropathy remains controversial. endoplasmic reticulum (er) stress plays an important role in the pathogenesis of dn. astragaloside iv (as-iv) is derived from astragalus membranaceus (fisch) bge, a widely used traditional herbal medicine in china, and has diverse pharmacological activities including the attenuation of podocyte injury and ... | 2015 | 25886386 |
| astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating tnf-α/pgc-1α signaling mediated energy biosynthesis. | we previously reported that astragalus polysaccharide (aps) extracted from chinese medicine astragalus membranaceus (fisch.) bge, attenuates hypertrophy of neonatal rat ventricular myocytes (nrvms) induced by isoproterenol (iso). the present study was designed to investigate the effects and the possible mechanism of aps on iso-induced hypertrophy in rats and nrvms with focus on tumor necrosis factor α (tnf-α)/peroxisome proliferator-activated receptor-γ coactivator 1α (pgc-1α) signaling mediated ... | 2015 | 25880160 |
| korean medicine therapy as a substitute for chemotherapy for metastatic breast cancer: a case report. | a 46-year-old korean woman was diagnosed with stage iii breast cancer and underwent 8 cycles of neoadjuvant chemotherapy, breast conservation surgery and adjuvant radiotherapy. however, the cancer recurred in the right upper lung (rul) and the right pulmonary hilum after 8 months. the rul nodule was removed through a wedge resection, and the pathologic finding was revealed as a metastatic adenocarcinoma. adjuvant chemotherapy was recommended, but she refused it because she feared adverse reactio ... | 2017 | 25848354 |
| comparison of two different astragali radix by a ¹h nmr-based metabolomic approach. | astragali radix (ar) is a commonly used herbal drug in traditional chinese medicine and is widely used for the treatment of diabetes, cardiovascular diseases, nephropathy, and neuropathy. the main source of ar in china is the dried root of astragalus membranaceus var. mongholicus (bge.) hsiao, and both cultivated and wild ars are used clinically. a systematic comparison of cultivated ar (gs-ar) and wild ar (sx-ar) should be performed to ensure the clinical efficacy and safety. in this study, the ... | 2015 | 25844502 |
| specific medicinal plant polysaccharides effectively enhance the potency of a dc-based vaccine against mouse mammary tumor metastasis. | dendritic cell (dc) vaccines are a newly emerging immunotherapeutic approach for the treatment and prevention of cancer, but major challenges still remain particularly with respect to clinical efficacy. engineering and optimization of adjuvant formulations for dc-based vaccines is one strategy through which more efficacious treatments may be obtained. in this study, we developed a new ex vivo approach for dc vaccine preparation. we evaluated two highly purified mixed polysaccharide fractions fro ... | 2015 | 25825910 |
| effect of astragaloside iv against rat myocardial cell apoptosis induced by oxidative stress via mitochondrial atp-sensitive potassium channels. | astragaloside is one of the most common traditional chinese medicines and is derived from astragalus membranaceus. astragaloside iv (asiv) is a monomer located in an extract of astragaloside. the current study investigated the protective effects of asiv against hydrogen peroxide (h2o2)-induced injury in cardiocytes and elucidated the mechanisms responsible for this protective effect. cultured neonatal rat cardiocytes were divided into five experimental groups as follows: i) dimethyl sulfoxide; i ... | 2015 | 25739067 |
| astragaloside iv protects against isoproterenol-induced cardiac hypertrophy by regulating nf-κb/pgc-1α signaling mediated energy biosynthesis. | we previously reported that astragaloside iv (asiv), a major active constituent of astragalus membranaceus (fisch) bge protects against cardiac hypertrophy in rats induced by isoproterenol (iso), however the mechanism underlying the protection remains unknown. dysfunction of cardiac energy biosynthesis contributes to the hypertrophy and nuclear factor κb (nf-κb)/peroxisome proliferator-activated receptor-γ coactivator 1α (pgc-1α) signaling gets involved in the dysfunction. the present study was ... | 2015 | 25738576 |
| biological active ingredients of traditional chinese herb astragalus membranaceus on treatment of diabetes: a systematic review. | diabetes mellitus (dm) is a serious chronic metabolic disease which disease afflicting at present now afflicts approximately 4% of world population worldwide. nowadays, the need for more potent and safe drugs to supply the present anti-diabetic and treated drugs has become an imperative. astragalus membranaceus, the most common chinese herb and key-component of many chinese herbal anti-diabetic formulas, is rich in anti-diabetic compounds: polysaccharides (aps), saponins (ass), and flavonoids (a ... | 2015 | 25723453 |
| the multi-targets integrated fingerprinting for screening anti-diabetic compounds from a chinese medicine jinqi jiangtang tablet. | jinqi jiangtang tablet is a traditional chinese anti-diabetic formula containing three ingredients: coptis chinensis franch. (dried rhizome of c. chinensis franch., coptis deltoidea c. y. cheng et hsiao and coptis teeta wall.), astragalus membranaceus (fisch.) bunge. (dried root of a. membranaceus (fisch.) bge. var. mongholicus (bge. ) hsiao and a. membranaceus (fisch.) bge. ) and lonicera japonica thunb. (dried alabastrum or with nascent flowers of l. japonica thunb. ). free radicals, α-glucosi ... | 2015 | 25698248 |
| investigation of chemomarkers of astragali radix of different ages and geographical origin by nmr profiling. | astragalus roots from astragalus membranaceus bunge or astragalus membranaceus var. mongholicus (bunge) hsiao are among the most popular traditional medicinal plants due to their diverse therapeutic uses based on their tonic, antinephritic, immunostimulant, hepatoprotectant, diuretic, antidiabetic, analgesic, expectorant and sedative properties. currently, the herb is produced or cultivated in various sites, including 10 different locations in china with very diverse environmental conditions. th ... | 2015 | 25690295 |
| formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis. | formononetin is a novel herbal isoflavonoid isolated from astragalus membranaceus and possesses antitumorigenic properties. in the present study, we investigated the anti-proliferative effects of formononetin on human non-small cell lung cancer (nsclc), and further elucidated the molecular mechanism underlying the anti-tumor property. mtt assay showed that formononetin treatment significantly inhibited the proliferation of two nsclc cell lines including a549 and nci-h23 in a time- and dose-depen ... | 2014 | 25674209 |
| formononetin promotes proliferation that involves a feedback loop of microrna-375 and estrogen receptor alpha in estrogen receptor-positive cells. | formononetin is an o-methylated isoflavone that is isolated from the root of astragalus membranaceus, and it has antitumorigenic effects. our previous studies found that formononetin triggered growth-inhibitory and apoptotic activities in mcf-7 breast cancer cells. to further investigate the potential effect of formononetin in promoting cell proliferation in estrogen receptor (er)-positive cells, we used in vivo and in vitro studies to elucidate the possible mechanism. erα-positive cells (huvec, ... | 2016 | 25663261 |
| total extract of yupingfeng attenuates bleomycin-induced pulmonary fibrosis in rats. | yupingfeng is a chinese herbal compound used efficaciously to treat respiratory tract diseases. total glucosides of yupingfeng have been proven effective in anti-inflammation and immunoregulation. nevertheless, the role of total extract of yupingfeng (yte) in pulmonary fibrosis (pf), a severe lung disease with no substantial therapies, remains unknown. present study was conducted to elucidate the anti-fibrotic activity of yte. the rat pf model was induced by intratracheal administration of bleom ... | 2015 | 25636879 |
| herb-drug interaction between an anti-hiv chinese herbal sh formula and atazanavir in vitro and in vivo. | with the prevalent use of highly active antiretroviral therapy (haart) for aids patients since 1996, the mortality of hiv/aids patients has been remarkably decreased. with long-term use of haart, drug resistance and side effects of antiretrovirals have been frequently reported, which not only reduce the efficacy, but also decreases the tolerance of patients. traditional herbal medicine has become more popular among hiv/aids patients as adjuvant therapy to reduce these adverse effects of haart. s ... | 2015 | 25614104 |
| biochanin a promotes proliferation that involves a feedback loop of microrna-375 and estrogen receptor alpha in breast cancer cells. | biochanin a and formononetin are o-methylated isoflavones that are isolated from the root of astragalus membranaceus, and have antitumorigenic effects. our previous studies found that formononetin triggered growth-inhibitory and apoptotic activities in mcf-7 breast cancer cells. we performed in vivo and in vitro studies to further investigate the potential effect of biochanin a in promoting cell proliferation in estrogen receptor (er)-positive cells, and to elucidate underlying mechanisms. | 2015 | 25613180 |
| astragaloside iv attenuates injury caused by myocardial ischemia/reperfusion in rats via regulation of toll-like receptor 4/nuclear factor-κb signaling pathway. | myocardial ischemia/reperfusion (mi/r) injury, in which inflammatory response and cell apoptosis play a vital role, is frequently encountered in clinical practice. astragaloside iv (asiv), a small molecular saponin of astragalus membranaceus, has been shown to confer protective effects against many cardiovascular diseases. the present study was aimed to investigate the antiinflammatory and antiapoptotic effects and the possible mechanism of asiv on mi/r injury in rats. rats were randomly divided ... | 2015 | 25604645 |
| astragaloside iv controls collagen reduction in photoaging skin by improving transforming growth factor-β/smad signaling suppression and inhibiting matrix metalloproteinase-1. | exposure to ultraviolet (uv) light reduces levels of type i collagen in the dermis and results in human skin damage and premature skin aging (photoaging). this leads to a wrinkled appearance through the inhibition of transforming growth factor‑β (tgf‑β)/smad signaling. uv irradiation increases type i collagen degradation through upregulating matrix metalloproteinase (mmp) expression. astragaloside iv (ast) is one of the major active components extracted from astragalus membranaceus. however, its ... | 2015 | 25591734 |
| [effects of atovaquone and astragalus combination on the treatment and il-2, il-12, ifn-γ levels on mouse models of acute toxoplasmosis]. | reactivation of toxoplasma gondii infections and serious clinical manifestations such as encephalitis may develop in immunocompromised subjects and aids patients. different protocols are used for the treatment of toxoplasmosis in high-risk patient groups, however life-long prophylactic therapy against reactivation risk in aids patients may lead to several undesired results. atovaquone is an effective antiprotozoal agent against toxoplasmosis with minor side effects. on the other hand, astragalus ... | 2014 | 25492659 |
| efficient production of isoflavonoids by astragalus membranaceus hairy root cultures and evaluation of antioxidant activities of extracts. | in this study, astragalus membranaceus hairy root cultures (amhrcs) were established as an attractive alternative source for the efficient production of isoflavonoids (if). a. membranaceus hairy root line ii was screened as the most efficient line and was confirmed by pcr amplification of rolb, rolc and aux1 genes. culture parameters of amhrcs were systematically optimized, and five main if constituents were quali-quantitatively determined by lc-ms/ms. under optimal conditions, the total if accu ... | 2014 | 25483292 |
| cloning, expression and purification of isoflavone-2'-hydroxylase from astragalus membranaceus bge. var. mongolicus (bge.) hsiao. | plant cytochrome p450 enzymes play vital roles in the biosynthesis of plant secondary metabolites, including phenylpropanoids and phytoalexins. isoflavone-2'-hydroxylase (ami2'h) from astragalus membranaceus bge. var. mongolicus (bge.) hsiao is a membrane protein and an eukaryotic cytochrome p450 enzyme involved in isoflavonoid biosynthesis. we cloned the ami2'h gene by employing race methods and modified the gene sequence to facilitate protein expression and increase protein solubility. two vec ... | 2015 | 25462811 |
| the combination of astragalus membranaceus and ligustrazine ameliorates micro-haemorrhage by maintaining blood-brain barrier integrity in cerebrally ischaemic rats. | haemorrhagic transformation is an asymptomatic event that frequently occurs after following ischaemic stroke, particularly when pharmaceutical thrombolysis is used. however, the mechanism responsible for haemorrhagic transformation remains unknown, and therapeutics have not been identified. in this study, we administered a combination of astragalus membranaceus and ligustrazine to rats with cerebral ischaemia that had undergone thrombolysis. we analysed the effect of this combination on the atte ... | 2014 | 25456435 |
| polysaccharides from angelica and astragalus exert hepatoprotective effects against carbon-tetrachloride-induced intoxication in mice. | this study aimed to investigate the effects of polysaccharide from angelica and astragalus (aap) on carbon tetrachloride (ccl4) induced liver damage in mice. a total of 120 kunming mice were randomly distributed among 6 groups comprising (i) the normal control mice, (ii) the ccl4 treatment group, (iii) the bifendate treatment group, (iv) the aap treatment group, (v) the angelica sinensis polysaccharide (asp) treatment group, and (vi) the astragalus membranaceus polysaccharide (amp) treatment gro ... | 2015 | 25415237 |
| profiling the metabolism of astragaloside iv by ultra performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry. | astragaloside iv is a compound isolated from the traditional chinese medicine astragalus membranaceus, that has been reported to have bioactivities against cardiovascular disease and kidney disease. there is limited information on the metabolism of astragaloside iv, which impedes comprehension of its biological actions and pharmacology. in the present study, an ultra-performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (uplc-q-tof-ms/ms)-based approach was d ... | 2014 | 25407723 |
| astragalus polysaccharide suppresses doxorubicin-induced cardiotoxicity by regulating the pi3k/akt and p38mapk pathways. | doxorubicin, a potent chemotherapeutic agent, is associated with acute and chronic cardiotoxicity, which is cumulatively dose-dependent. astragalus polysaccharide (aps), the extract of astragalus membranaceus with strong antitumor and antiglomerulonephritis activity, can effectively alleviate inflammation. however, whether aps could ameliorate chemotherapy-induced cardiotoxicity is not understood. here, we investigated the protective effects of aps on doxorubicin-induced cardiotoxicity and eluci ... | 2014 | 25386226 |
| induction of angiogenesis in zebrafish embryos and proliferation of endothelial cells by an active fraction isolated from the root of astragalus membranaceus using bioassay-guided fractionation. | the objective of the study was to identify the active fraction(s) from ar aqueous extract responsible for promoting angiogenesis using bioassay-guided fractionation. the angiogenic activity was screened by monitoring the increase of sprout number in sub-intestinal vessel (siv) of the transgenic zebrafish embryos after they were treated with 0.06-0.25 mg/ml of ar aqueous extract or its fraction(s) for 96 h. furthermore, the angiogenic effect was evaluated in treated zebrafish embryos by measuring ... | 2014 | 25379465 |
| [study on method and its optimization of improving seed germination of astragalus membranaceus as gansu traditional medicinal herb]. | to break the hard testa and improve seed germination situation of astragalus membranaceus var. mongholicus, in order to solve the problems of low success rate of seed germination and seedling. | 2014 | 25345121 |
| identifying roles of "jun-chen-zuo-shi" component herbs of qishenyiqi formula in treating acute myocardial ischemia by network pharmacology. | the role of "jun-chen-zuo-shi" (also known as "sovereign-minister-assistant-courier") component herbs of chinese medicine is not fully understood. this study aims to test the "jun-chen-zuo-shi" rule with the qishenyiqi formula (qsyq) on treating acute myocardial ischemia (ami) by a network pharmacology approach. | 2014 | 25342960 |
| astragalus (a traditional chinese medicine) for treating chronic kidney disease. | astragalus (radix astragali, huang qi) is the dried root of astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao or astragalus membranaceus (fisch.) bge. (family leguminosae). it is one of the most widely used herbs in traditional chinese medicine for treating kidney diseases. evidence is needed to help clinicians and patients make judgments about its use for managing chronic kidney disease (ckd). | 2014 | 25335553 |
| molecular signalings in keloid disease and current therapeutic approaches from natural based compounds. | keloid is an excessive dermal scar occurring in response to skin injuries. several therapeutic strategies have been proposed to ease the aggressiveness of keloid scarring. even though the principle mechanism underlying the disease propagation still remains unidentified, several signaling pathways were highly focused as plausible pathways involving keloid formation, including transforming growth factor-beta 1 (tgf-β1), mitogen-activated protein kinase (mapk), insulin-like growth factor-i (igf-i), ... | 2015 | 25331681 |
| astragalus saponins modulates colon cancer development by regulating calpain-mediated glucose-regulated protein expression. | glucose-regulated proteins (grp) are induced in the cancer microenvironment to promote tumor survival, metastasis and drug resistance. ast was obtained from the medicinal plant astragalus membranaceus, which possesses anti-tumor and pro-apoptotic properties in colon cancer cells and tumor xenograft. the present study aimed to investigate the involvement of grp in endoplasmic reticulum (er) stress-mediated apoptosis during colon cancer development, with focus on the correlation between ast-evoked ... | 2014 | 25319833 |
| formononetin promotes cell cycle arrest via downregulation of akt/cyclin d1/cdk4 in human prostate cancer cells. | formononetin is an o-methylated isoflavone isolated from the root of astragalus membranaceus. it has already been reported that formononetin could inhibit cell proliferation and induce cell apoptosis in several cancers, including prostate cancer. this study aimed to further investigate whether cell cycle arrest is involved in formononetin-mediated antitumor effect in human prostate cancer cells, along with the underlying molecular mechanism. | 2014 | 25301361 |
| effect of astragalus membranaceus extract on diabetic nephropathy. | diabetic nephropathy, a microvascular complication of diabetes, is a progressive kidney disease caused by angiopathy of the capillaries in the kidney glomeruli. herein, we report a case of a 62-year-old patient with a 30 year history of diabetes, who showed a substantial improvement in diabetic nephropathy on administration of 30 g of astragalus membranaceus extract per day. after 1 month, estimated glomerular filtration rate increased from 47 to 72 ml/min per 1.73 m(2) and was subsequently main ... | 2014 | 25298884 |
| astragalus membranaceus modulates th1/2 immune balance and activates pparγ in a murine asthma model. | astragalus membranaceus, a traditional chinese herb, has been used to improve airway inflammation and asthma. the present study investigated whether a. membranaceus has immunotherapeutic effects on asthma, a chronic inflammatory mucosal disease that is associated with excess production of ige, eosinophilia, t helper 2 (th2) cytokines, and bronchial hyperresponsiveness. an ovalbumin (ova)-induced, chronic inflammatory airway murine asthma model was used to examine the status of pulmonary inflamma ... | 2014 | 25264079 |
| the standardized bhh10 extract, a combination of astragalus membranaceus, cinnamomum cassia, and phellodendron amurense, reverses bone mass and metabolism in a rat model of postmenopausal osteoporosis. | jasin-hwan-gagambang (bhh10), a modified prescription of jasin-hwan, contains astragalus membranaceus, cinnamomum cassia, and phellodendron amurense, and it has been traditionally used to treat osteoporosis and other inflammatory diseases. in this study, we systematically investigated the protective effects of bhh10 in ovariectomy (ovx)-induced rats. sprague-dawley rats were randomly divided into sham and ovx subgroups. the rats in the ovx group were treated with vehicle, bhh10, alendronate (aln ... | 2015 | 25230217 |
| effect of fermentation time on antioxidative activities of ganoderma lucidum broth using leguminous plants as part of the liquid fermentation medium. | oxidative damage plays an important role in the pathology of human diseases. ganoderma lucidum, a medicinal fungus, has been used for thousands of years in traditional oriental medicine. it is reported to have antioxidant functions such as inhibition of lipid peroxidation. the objective of the present study was to investigate the effect of fermentation time on the antioxidative activities of g. lucidum broth filtrate using leguminous plants as part of the liquid fermentation medium. inhibition o ... | 2011 | 25213931 |
| the mechanism of astragaloside iv promoting sciatic nerve regeneration. | 3-o-beta-d-xylopyranosyl-6-o-beta-d-glucopyranosyl-cycloastragenol (astragaloside iv), the main active component of the traditional chinese medicine astragalus membranaceus, has been shown to be neuroprotective. this study investigated whether astragaloside iv could promote the repair of injured sciatic nerve. denervated sciatic nerve of mice was subjected to anastomosis. the mice were intraperitoneally injected with 10, 5, 2.5 mg/kg astragaloside iv per day for 8 consecutive days. western blot ... | 2013 | 25206535 |
| astragaloside iv inhibits platelet-derived growth factor-bb-stimulated proliferation and migration of vascular smooth muscle cells via the inhibition of p38 mapk signaling. | astragaloside iv (as-iv), the major active component extracted from astragalus membranaceus, has been demonstrated to exhibit protective effects on the cardiovascular, immune, digestive and nervous systems; thus, has been widely used in traditional chinese medicine. abnormal proliferation and migration of vascular smooth muscle cells (vsmcs) is closely associated with the initiation and progression of cardiovascular diseases, including atherosclerosis and restenosis. however, the effects of as-i ... | 2014 | 25187834 |
| protective effects of astragaloside iv against ovalbumin-induced lung inflammation are regulated/mediated by t-bet/gata-3. | bronchial asthma is characterized by chronic lung inflammation, airway hyperresponsiveness, and airway remodelling. astragaloside iv (3-o-β-d-xylopyranosyl-6-o-β-d-glucopyranosyl-cycloastragenol, ast), the primary pure saponin isolated from the root of astragalus membranaceus, is an effective compound with distinct pharmacological effects including anti-inflammation, immunoregulation, and antifibrosis. however, the effect of ast on asthma remains unclear. in the present study, in the murine mode ... | 2014 | 25171656 |
| astragaloside iv alleviates early brain injury following experimental subarachnoid hemorrhage in rats. | astragaloside iv, one of the main effective components isolated from astragalus membranaceus, has multiple neuroprotective properties, while the effects of astragaloside iv on the attenuation of subarachnoid hemorrhage (sah)-induced early brain injury (ebi) and its possible mechanisms are unknown. in the present study, we aimed to determine whether astragaloside iv could inhibit oxidative stress, reduce neuronal apoptosis, and improve neurological deficits after experimental sah in rats. rats (n ... | 2014 | 25136262 |
| effect of astragalus polysaccharides on expression of tnf-α, il-1β and nfatc4 in a rat model of experimental colitis. | astragalus membranaceus is a chinese medicinal herb and has been shown to improve hapten-induced experimental colitis. one of its major components is polysaccharides. we investigated the effect of astragalus polysaccharides (aps) on expression of tnf-α, il-1β and nfatc4 in a rat model of experimental colitis. | 2014 | 25132256 |
| astragalus membranaceus injection combined with conventional treatment for viral myocarditis: a systematic review of randomized controlled trials. | to assess the efficacy and safety of astragalus membranaceus injection combined with conventional therapy in the treatment of viral myocarditis. | 2014 | 25098261 |
| cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. | cycloastragenol (cag) is an aglycone of astragaloside iv. it was first identified when screening astragalus membranaceus extracts for active ingredients with antiaging properties. the present study demonstrates that cag stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. in particular, cag promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro. the distinct telomerase-activating property of cag prompted evaluation of its potential app ... | 2014 | 25095809 |
| [autotoxicity of aqueous extracts from plant of cultivated astragalus membranaceus var. mongholicus]. | to exploring the relationship between continuous cropping obstacle and autotoxicity of astragalus membranaceus var. mongholicus, autotoxic effect of plant aqueous extract were determined. | 2014 | 25095333 |
| effects of traditional chinese medicinal plants on anti-insulin resistance bioactivity of dxms-induced insulin resistant hepg2 cells. | medicinal plants have a long history of use in china to treat diabetic symptoms. ancient chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in china for the treatment of diabetic symptoms. based on a systematic ancient chinese medical manuscripts review in combination with ethnobotanical survey, 16 medicinal plants for the traditional treatment of diabetic symptoms were identified for the evaluation of anti-insulin resistance bioactiv ... | 2014 | 25089237 |
| review of the botanical characteristics, phytochemistry, and pharmacology of astragalus membranaceus (huangqi). | astragalus membranaceus is one of the most widely used traditional chinese herbal medicines. it is used as immune stimulant, tonic, antioxidant, hepatoprotectant, diuretic, antidiabetic, anticancer, and expectorant. the current paper reviews the botanical characteristics, phytochemistry, and pharmacology of astragali radix. information on astragali radix was gathered via the internet (using google scholar, baidu scholar, elsevier, acs, medline plus, cnki, and web of science) as well as from libr ... | 2014 | 25087616 |
| genotoxicity study of polysaccharide fraction from astragalus membranaceus's aerial parts. | radix astragali, the root of astragalus (a.) membranaceus, has been applied in a variety of diseases for a long time in asian countries such as korea and china. in addition, the aerial parts such as leaves and stems of a. membranaceus have received a great deal of attention. recently, the polysaccharide fraction showing a potent immunomoduating activity was isolated from the aerial parts of a. membranaceus. thus, the aerial parts of a. membranaceus would be worthy enough for a food material and ... | 2014 | 25071923 |
| accumulation of astragalosides and related gene expression in different organs of astragalus membranaceus bge. var mongholicus (bge.). | astragalus membranaceus is one of the most important traditional korean and chinese medicinal herbs because it contains triterpenoid saponins (astragaloside i, ii, iii, and iv), which have beneficial and pharmacological effects on health. in this study, we analyzed 10 mevalonate pathway genes that are involved in astragaloside biosynthesis using the illumina/solexa hiseq2000 platform. we determined the expression levels of the 10 genes using quantitative real-time pcr, and analyzed the accumulat ... | 2014 | 25068786 |
| astragalus membranaceus inhibits peritoneal fibrosis via monocyte chemoattractant protein (mcp)-1 and the transforming growth factor-β1 (tgf-β1) pathway in rats submitted to peritoneal dialysis. | inflammation and transforming growth factor-β1 (tgf-β1) contribute to the development of peritoneal fibrosis (pf), which is associated with peritoneal dialysis (pd). astragalus membranaceus (astragalus) has anti-inflammatory and anti-fibrotic effects in many diseases. the goal of this study was to determine the anti-fibrotic effects of astragalus on the pf response to pd. a rat model of pd was induced using standard pd fluid, and pf was verified by he and masson's staining, as well as through th ... | 2014 | 25054320 |
| optimization of enzyme assisted extraction of polysaccharides from astragalus membranaceus. | astragalus polysaccharide (aps) is known to have a variety of pharmacological activities. in the present study, enzyme assisted extraction of aps from astragalus mongholicus using various enzymes were examined. research found that glucose oxidase offered a better performance in enhancement of extraction yields of aps than other ones. glucose oxidase assisted extraction process was further optimized by using response surface method (rsm) to obtain maximum yield of crude aps. the optimized extract ... | 2014 | 25037388 |
| astragaloside iv inhibits progression of lung cancer by mediating immune function of tregs and ctls by interfering with ido. | tumor cells have developed multiple mechanisms to escape immune recognition mediated by t cells. indoleamine 2,3-dioxygenase (ido), a tryptophan-catabolizing enzyme inducing immune tolerance, is involved in tumor escape from host immune systems in mice. astragaloside iv (as-iv), an extract from a commonly used chinese medicinal plant astragalus membranaceus, has been shown to be capable of restoring the impaired t-cell functions in cancer patients. the purpose of this study was to investigate th ... | 2014 | 24980548 |
| formononetin inhibits migration and invasion of mda-mb-231 and 4t1 breast cancer cells by suppressing mmp-2 and mmp-9 through pi3k/akt signaling pathways. | formononetin is a naturally existing isoflavone, which can be found in the roots of astragalus membranaceus, trifolium pratense, glycyrrhiza glabra, and pueraria lobata. it was found to be associated with inhibition of cell proliferation and cell cycle progression, as well as induction of apoptosis in various cancer cell lines. however, the effect of formononetin on breast cancer cell metastasis remains unclear. in this study, we examined the effect of formononetin on the migration and invasion ... | 2014 | 24977660 |
| herbal extract sh003 suppresses tumor growth and metastasis of mda-mb-231 breast cancer cells by inhibiting stat3-il-6 signaling. | cancer inflammation promotes cancer progression, resulting in a high risk of cancer. here, we demonstrate that our new herbal extract, sh003, suppresses both tumor growth and metastasis of mda-mb-231 breast cancer cells via inhibiting stat3-il-6 signaling path. our new herbal formula, sh003, mixed extract from astragalus membranaceus, angelica gigas, and trichosanthes kirilowii maximowicz, suppressed mda-mb-231 tumor growth and lung metastasis in vivo and reduced the viability and metastatic abi ... | 2014 | 24976685 |
| astragalus polysaccharide inhibits isoprenaline-induced cardiac hypertrophy via suppressing ca²⁺-mediated calcineurin/nfatc3 and camkii signaling cascades. | pathological cardiac hypertrophy induced by increased sympathetic drive can subsequently lead to congestive heart failure, which represents the major cause of morbidity and mortality worldwide. astragalus polysaccharide (aps) is an active compound extracted from chinese herb astragalus membranaceus (am), a frequently used "qi-invigorating" herbal medicine in traditional medicine broadly used for the treatment of cardiovascular and other diseases. currently, little is known about the effect of ap ... | 2014 | 24975447 |
| astragalus membranaceus up-regulate cosmc expression and reverse iga dys-glycosylation in iga nephropathy. | decreased core i β3-gal-t-specific molecular chaperone (cosmc) expression induced iga1 aberrant glycosylation is the main characteristic of iga nephropathy (igan). this study tried to elucidate the effect of astragalus membranaceus on cosmc expression and iga o-glycosylation of peripheral b lymphocytes in igan patients. | 2014 | 24942185 |
| myelo-enhancement by astragalus membranaceus in male albino rats with chemotherapy myelo-suppression. histological and immunohistochemical study. | myelosuppression is the most common toxicity encountered in the oncology clinic today. this study was planned to investigate the possible protective and therapeutic role of the traditional chinese medicinal herb; astragalus membranaceus (am), on chemotherapy-induced myelosuppression. | 2014 | 24921023 |
| protective effects of astragaloside iv against amyloid beta1-42 neurotoxicity by inhibiting the mitochondrial permeability transition pore opening. | mitochondrial dysfunction caused by amyloid β-peptide (aβ) plays an important role in the pathogenesis of alzheimer disease (ad). substantial evidence has indicated that the mitochondrial permeability transition pore (mptp) opening is involved in aβ-induced neuronal death and reactive oxygen species (ros) generation. astragaloside iv (as-iv), one of the major active constituents of astragalus membranaceus, has been reported as an effective anti-oxidant for treating neurodegenerative diseases. ho ... | 2014 | 24905226 |
| accumulation of flavonoids and related gene expressions in different organs of astragalus membranaceus bge. | astragalus membranaceus is one of the important medicinal plant in china and korea. it is used to increase metabolism and digestion, enhance the immune system, and promote the healing of wounds and injuries. in the present study, we used quantitative real-time pcr to investigate the expression of genes related to the biosynthesis of flavonoids, in addition to high-performance liquid chromatography to assess calycosin and calycosin-7-o-β-d-glucoside accumulation, in the different plant organs of ... | 2014 | 24903957 |
| selenium-dependent antitumor immunomodulating activity of polysaccharides from roots of a. membranaceus. | roots of astragalus membranaceus (fish.) bge. var. mongholicus (bge.) hsiao (a. membranaceus) have been long used as an auxiliary reagent supporting cancer treatment. here, we compared the chemical composition and antitumor immunomodulating activity of polysaccharides from roots of a. membranaceus (pams) from five major habitats in inner mongolia, pr china. we revealed that compositions of monosaccharides and amino acids were comparable among pams from different habitats. however, amounts of sel ... | 2014 | 24857867 |
| an integrated analysis for determining the geographical origin of medicinal herbs using icp-aes/icp-ms and (1)h nmr analysis. | icp-ms and (1)h nmr are commonly used to determine the geographical origin of food and crops. in this study, data from multielemental analysis performed by icp-aes/icp-ms and metabolomic data obtained from (1)h nmr were integrated to improve the reliability of determining the geographical origin of medicinal herbs. astragalus membranaceus and paeonia albiflora with different origins in korea and china were analysed by (1)h nmr and icp-aes/icp-ms, and an integrated multivariate analysis was perfo ... | 2014 | 24837936 |
| identification of angelica oil as a suppressor for the biological properties of danggui buxue tang: a chinese herbal decoction composes of astragali radix and angelica sinensis radix. | danggui buxue tang (dbt), a chinese herbal decoction commonly used in treating women׳s ailments, contains two herbs: angelica sinensis radix (asr) and astragali radix (ar). traditionally, asr had to be pre-treated with yellow wine before the herbal preparation, which reduced the amount of volatile oil in water extract of asr and dbt, and meanwhile the volatile oil-reduced dbt processed better bioactivities in cell cultures. the present study aimed to investigate the effect of volatile oil from a ... | 2014 | 24837305 |
| high-throughput analysis and characterization of astragalus membranaceus transcriptome using 454 gs flx. | astragalus membranaceus (fisch.) bge (ar), one of the most important medicinal plants in asia, was found to exhibit various bioactivities. due to limited genomic and transcriptomic data, the biosynthetic pathway of the major bioactive compound in ar, is currently unclear. in this study, 454 gs flx technology was employed to produce a substantial expressed sequence tag (est) dataset from the ar. in all, 742721 high-quality reads from the ar were produced using roche gs flx titanium. a total of 98 ... | 2014 | 24828103 |
| a network pharmacology study of chinese medicine qishenyiqi to reveal its underlying multi-compound, multi-target, multi-pathway mode of action. | chinese medicine is a complex system guided by traditional chinese medicine (tcm) theories, which has proven to be especially effective in treating chronic and complex diseases. however, the underlying modes of action (moa) are not always systematically investigated. herein, a systematic study was designed to elucidate the multi-compound, multi-target and multi-pathway moa of a chinese medicine, qishenyiqi (qsyq), on myocardial infarction. qsyq is composed of astragalus membranaceus (huangqi), s ... | 2014 | 24817581 |
| in vitro synergistic antioxidant activity and identification of antioxidant components from astragalus membranaceus and paeonia lactiflora. | many traditionally used herbs demonstrate significantly better pharmacological effects when used in combination than when used alone. however, the mechanism underlying this synergism is still poorly understood. this study aimed to investigate the synergistic antioxidant activity of astragalus membranaceus (ame) and paeonia lactiflora (pl), and identify the potential antioxidant components by 1,1-diphenyl-2-picrylhydrazine (dpph) radical spiking test followed by a high performance liquid chromato ... | 2014 | 24816851 |
| astragalus membranaceus as a cause of increased ca19-9 and liver and kidney cysts: a case report. | astragalus membranaceus, one of the most common chinese herbs, is widely used to prevent and treat a variety of diseases. very few adverse reactions, caused by a. membranaceus, have been reported in the literature. the purpose of this article was to report a case of marked increase in carbohydrate antigen 19-9 (ca19-9) and the formation of liver and kidney cysts following oral administration of a. membranaceus. | 2014 | 24806627 |
| astragalus saponin attenuates the expression of fibrosis-related molecules in irradiated cardiac fibroblasts. | the main pathological change of radiation-induced heart disease is fibrosis. emerging evidence has indicated that astragalus membranaceus and its extractant, astragalus saponin (ast), were used for treating fibrosis diseases. in the present study, the effects of ast on fibrosis damage induced by irradiation were determined. after being irradiated with 1 or 2-gy x-rays, obvious changes of endoplasmic reticulum morphology were observed in cardiac fibroblasts (cfs), suggesting that its protein proc ... | 2014 | 24739634 |
| a chinese 2-herb formula (nf3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats. | diabetic foot ulcer is closely associated with peripheral vascular disease. enhancement of tissue oxidative stress, reduction of nitric oxide (no) and angiogenic growth factors, and abnormal matrix metalloproteinase (mmp) activity are pathophysiological factors in post-ischemic neovascularization and diabetic wound healing. our previous study demonstrated that the chinese 2-herb formula, nf3, showed significant wound healing effects on diabetic foot ulcer rats. a novel rat diabetic foot ulcer wi ... | 2016 | 24731763 |
| the effect of astragalus polysaccharide on the epstein-barr virus lytic cycle. | effects of a polysacharide from chinese herbal plant astragalus membranaceus (aps) on the expression of epstein-barr virus (ebv) immediate early proteins zta, rta and ea-d in raji cells were examined. ebv switch from latent to lytic cycle in raji cells was induced by 12-o-tetradecanoylphorbol-13-acetate (tpa) and sorbol butyrate (sb) and the effects of aps were examined by immunofluorescence, western blotting and flow cytometry. aps in a non-cytotoxic concentration of 30 μg/ml significantly supp ... | 2014 | 24717032 |
| antihepatoma and liver protective potentials of ganoderma lucidum ( ling zhi) fermented in a medium containing black soybean ( hēi dòu) and astragalus membranaceus ( shēng huáng qí). | the antihepatoma activity and liver protective function of the fermentation products (5 l fermenator) of ganoderma lucidum (gl; ling zhi) cultivated in a medium containing black soybean (bs; hēi dòu) and astragalus membranaceus (am; shēng huáng qí) at different fermentation temperatures were investigated in this study. hep 3b cells pretreated with lovastatin were used to study the antihepatoma activity, and possible active components were analyzed by reverse-phase high-performance liquid chromat ... | 2013 | 24716165 |
| functional assessment of pharmacological telomerase activators in human t cells. | telomeres are structures at the ends of chromosomes that shorten during cell division and eventually signal an irreversible state of growth arrest known as cellular senescence. to delay this cellular aging, human t cells, which are critical in the immune control over infections and cancer, activate the enzyme telomerase, which binds and extends the telomeres. several different extracts from the astragalus membranaceus root have been documented to activate telomerase activity in human t cells. th ... | 2013 | 24709644 |
| anti-stress effect of astragaloside iv in immobilized mice. | astragaloside iv, a major component extracted from the roots of astragalus membranaceus (am), possesses anti-inflammatory, anti-oxidative, anti-fibrotic, anti-infarction and immunoregulatory effects. to clarify anti-stress effect of am, anxiolytic and anti-inflammatory effects of 80% ethanol extract of am and astragaloside iv were investigated in immobilization stress model. | 2014 | 24709311 |
| beneficial effects of astragaloside iv for hair loss via inhibition of fas/fas l-mediated apoptotic signaling. | apoptosis with premature termination of hair follicle growth induces several types of hair loss and is one of the crucial factors of hair loss. astragaloside iv, which is a major component of astragalus membranaceus, is a cycloartane triterpene saponin. although an anti-apoptotic effect of astragaloside iv has been reported, its effects against hair loss have not been investigated. to explore the underlying mechanisms of astragaloside iv on apoptotic signaling in hair follicle, the dorsal skin o ... | 2014 | 24676213 |
| oral chinese herbal medicine combined with pharmacotherapy for stable copd: a systematic review of effect on bode index and six minute walk test. | this systematic review evaluated the effects of chinese herbal medicine (chm) plus routine pharmacotherapy (rp) on the objective outcome measures bode index, 6-minute walk test (6mwt), and 6-minute walk distance (6mwd) in individuals with stable chronic obstructive pulmonary disease (copd). searches were conducted of six english and chinese databases (pubmed, embase, central, cinahl, cnki and cqvip) from their inceptions until 18th november 2013 for randomized controlled trials involving oral ad ... | 2014 | 24622390 |
| astragalus membranaceus improves exercise performance and ameliorates exercise-induced fatigue in trained mice. | astragalus membranaceus (am) is a popular "qi-tonifying" herb with a long history of use as a traditional chinese medicine with multiple biological functions. however, evidence for the effects of am on exercise performance and physical fatigue is limited. we evaluated the potential beneficial effects of am on ergogenic and anti-fatigue functions following physiological challenge. male icr strain mice were randomly assigned to four groups (n = 10 per group) for treatment: (1) sedentary control an ... | 2014 | 24595275 |
| the in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action. | lycium barbarum and astragalus membranaceus are two traditional medicinal herbs widely used in china for nourishing yin and reinforcing qi. the purpose of the study was to investigate the prophylactic and curative effects of crude polysaccharides (qhps) extracted from a two-herb formula composed of lycium barbarum and astragalus membranaceus at a ratio of 2:3 in colitis rats, and to further elucidate the potential mechanism of action in epithelial cell proliferation in vitro. | 2014 | 24548752 |
| qu feng xuan bi formula attenuates anaphylactic rhinitis-asthma symptoms via reducing eos count and regulating t cell function in rat ara models. | aqueous extract of qu feng xuan bi formula (qfxbf, a chinese herb formula) which composed of radix glycyrrhizae, radix glycyrrhizae preparata, paeonia sterniana fletcher in journ, pheretima, allium macrostemon bunge, astragalus membranaceus (fisch) bunge and divaricate saposhnikovia root has been used in treatment of allergic rhinitis and asthma (ara) as an approved hospital prescription for many years in jiangsu province hospital of traditional chinese medicine, china. the present study was des ... | 2014 | 24548751 |
| nonsteroidal anti-inflammatory drug activated gene-1 (nag-1) modulators from natural products as anti-cancer agents. | natural products are rich sources of gene modulators that may be useful in prevention and treatment of cancer. recently, nonsteroidal anti-inflammatory drug (nsaid) activated gene-1 (nag-1) has been focused as a target of action against diverse cancers like colorectal, pancreatic, prostate, and breast. a variety of natural agents have been reported to play a pivotal role in regulation of nag-1 through multiple transcriptional mechanisms. the aim of this paper is to review the nag-1 modulators de ... | 2014 | 24530873 |
| astragaloside iv attenuates inflammatory cytokines by inhibiting tlr4/nf-кb signaling pathway in isoproterenol-induced myocardial hypertrophy. | astragaloside iv(as iv) is one of the main effective components isolated from the traditional chinese medical herb astragalus membranaceus. the protective effect of astragalus membranaceus on myocardial hypertrophy has been extensively proved. to test the hypothesis that astragaloside iv can ameliorate the myocardial hypertrophy and inflammatory effect induced by β-adrenergic hyperactivity, we carried out in vivo and in vitro experiments. | 2013 | 24513635 |
| astragaloside iv possesses antiarthritic effect by preventing interleukin 1β-induced joint inflammation and cartilage damage. | the saponin astragaloside iv (ast) is one of major active components purified from astragalus membranaceus (fisch) bge, which has been used in traditional chinese medicine to treat immune disorders including rheumatoid arthritis (ra). the effects of ast on the suppression of experimental arthritis and its possible mechanisms are unknown. we measured the paw swelling of ankle joints, splenocyte proliferation, interleukin 1β (il-1β), tumor necrosis factor α (tnfα) and nitric oxide (no) formation b ... | 2014 | 24469603 |
| pharmacokinetic interaction of astragaloside iv with atractylenolide i and prim-o-glucosylcimifugin in male sprague dawley rats. | astragaloside iv, atractylenolide i, and prim-o-glucosylcimifugin are main medicinal components of the traditional chinese medicine prescription yu-ping-feng which is composed of three herbs: astragalus membranaceus, atractylodes macrocephala, and saposhnikovia divaricata. this study is aimed to assess the influence of atractylenolide i and prim-o-glucosylcimifugin on the pharmacokinetic profile of astragaloside iv so as to investigate the pharmacokinetic mechanisms of the yu-ping-feng prescript ... | 2014 | 24452462 |
| [treatment of severe active systemic lupus erythematosus by pmc therapy combined langchuang fuzheng jiedu capsule: a clinical observation]. | to evaluate the efficacy and safety of pmc therapy (prednisone, methotrexate, chloroquine) combined langchuang fuzheng jiedu capsule (lfjc), thus choosing a better therapy of integrative medicine for sle in the period of glucocorticoid use. | 2013 | 24432670 |
| astragaloside iv attenuates inflammatory cytokines by inhibiting tlr4/nf-кb signaling pathway in isoproterenol-induced myocardial hypertrophy. | astragaloside iv (as iv) is one of the main effective components isolated from the traditional chinese medical herb astragalus membranaceus. the protective effect of astragalus membranaceus on myocardial hypertrophy has been extensively proved. to test the hypothesis that astragaloside iv can ameliorate the myocardial hypertrophy and inflammatory effect induced by β-adrenergic hyperactivity, we carried out in vivo and in vitro experiments. | 2013 | 24432369 |