Publications

epizootiologic factors of fascioloides magna (trematoda) in oregon and southern washington.		1967	6068250
histochemical localization of cholinesterase activity in fascioloides magna (bassi) 1875.		1970	5527572
fascioloides magna in the pig--3 cases.		1971	5106718
fascioloides magna (bassi, 1875) ward, 1917 (trematoda) in woodland caribou, rangifer tarandus caribou (gmelin), of northeastern quebec, and its distribution in wild ungulates in canada.		1971	5101972
the occurrence of fascioloides magna and fasciola hepatica together in the livers of naturally infected cattle in south texas, and the incidence of the flukes in cattle, white-tailed deer, and feral hogs.		1972	5078583
survival of metacercariae of fascioloides magna in water at room temperature and under refrigeration.		1972	5022879
further observations on the survival of metacercariae of fascioloides magna in water at room temperature and under refrigeration.		1974	4821120
efficacy of rafoxanide and oxyclozanide against fascioloides magna in naturally infected cattle.		1974	4819720
parelaphostrongylus tenuis (nematoda) and fascioloides magna (trematoda) in moose of southeastern manitoba.		1974	4817542
action of oxyclozanide against adult fascioloides magna (bassi, 1875) infections in white-tailed deer.		1973	4687498
galba modicella and lymnaea stagnalis as experimental intermediate hosts for fascioloides magna in minnesota.		1973	4687484
ovulation of the trematode fascioloides magna in relation to the duration of parasitation.		1972	4677617
letter: lymnaea tomentosa from australia, an experimental intermediate host of the large american liver fluke, fascioloides magna.		1974	4447532
activity of closantel against experimentally induced fascioloides magna infection in sheep.	the efficacy of closantel against experimentally induced fascioloides magna infection in sheep was studied. in each of 3 experiments, closantel was administered 8 weeks after the sheep were given (oral inoculation) 100 metacercariae of f magna. in the 1st experiment, closantel was given orally to 5 groups of 6 sheep each at dosages of 0 (nontreated control), 5, 7.5, 10, and 15 mg/kg of body weight. in the 2nd and 3rd experiments, groups of 10 or 12 sheep were treated to confirm the efficacy of t ...	1985	4083587
efficacy of clorsulon and albendazole against fascioloides magna in naturally infected white-tailed deer.	the efficacy of clorsulon and of albendazole against fascioloides magna were evaluated in 36 naturally infected white-tailed deer (odocoileus virginianus) in southern texas. a single oral dose of clorsulon suspension (12 to 30 mg/kg of body weight; mean = 24 mg/kg) was given to each deer and killed 153 (92%) of 167 mature flukes and 4 (80%) of 5 immature flukes recovered at necropsy. a single oral dose of albendazole paste (17 to 46 mg/kg; mean = 26 mg/kg) was given to each deer and killed 148 ( ...	1985	4077630
pathophysiologic effects of experimentally induced fascioloides magna infection in sheep.	the pathophysiologic responses of 13 sheep inoculated orally with 100 metacercariae of fascioloides magna were monitored for 4 months after inoculation. there were no differences in weight gains between these and a number of noninoculated control sheep throughout the experiment. complete blood cell counts showed an increase only in the absolute number of eosinophils. serum preparations (2 times a week) from 7 inoculated and 7 noninoculated sheep did not identify any significant changes in alkali ...	1985	4037489
comparative efficacy of clorsulon and albendazole against fasciola hepatica in cattle.	in a dosage-confirmation trial, anthelmintic activities of clorsulon and albendazole against fasciola hepatica were evaluated and compared. twenty-eight cattle (8 to 12 months old) with natural f hepatica infections were randomly allotted to 4 groups of 7 cattle each: group 1, no treatment (controls); group 2, clorsulon suspension given orally at 3.5 mg/kg of body weight; group 3, clorsulon suspension given orally at 7 mg/kg; and group 4, albendazole paste given orally at 10 mg/kg. at necropsies ...	1985	4026039
in vitro excystment of metacercariae of fascioloides magna (trematoda).		1985	3998966
scanning electron microscopy and chemical excystation of fascioloides magna (trematoda) metacercariae.	scanning electron microscopy was used to study encysted metacercariae and newly excysted juveniles of fascioloides magna. the outer cyst was rough, coarse and discontinuous in the ventral aspect; the inner cyst was smooth. the newly excysted metacercaria was plump and contained numerous tegumentary spines; large dome-shaped papillae were prominent around the oral sucker and on the rim of the acetabulum. encysted metacercariae with outer cysts were excysted in an alkaline bile salts-trypsin mediu ...	1986	3776316
prevalence of fascioloides magna in cattle and deer in michigan.	a survey among 1.12 million cattle slaughtered in 357 packing plants in michigan during 1977 to 1981 was conducted to determine the prevalence of liver fluke infection. the condemnation rate of liver fluke-infected livers was 0.41, 3.7, and 13.9% in the southern, northern-lower, and upper regions of michigan, respectively. the same trend in infection rates was observed in white-tailed deer that had been examined in diagnostic laboratories in the state. a serologic survey among 50 randomly select ...	1987	3667410
evaluation of clorsulon against immature fascioloides magna in cattle and sheep.	efficacy of clorsulon was evaluated against infection with immature fascioloides magna in 24 cattle and 12 sheep. infections were induced by oral administration of 600 metacercariae/host. in cattle, clorsulon at dosages of 7 and 21 mg/kg of body weight was 65 and 100% effective against 8-week-old flukes, and 20 and 74% effective against 16-week-old flukes, respectively. in sheep, clorsulon at a dosage of 21 mg/kg was 92% effective against 8-week-old flukes. significantly (p less than 0.05) more ...	1988	3421522
efficacy of clorsulon against fascioloides magna infection in sheep.	in a study to evaluate the efficacy of clorsulon against fascioloides magna infection in sheep, 12 ewes were inoculated orally with 100 metacercariae of f magna, and 6 were treated with clorsulon (15 mg/kg of body weight) 8 weeks after inoculation. the sheep were euthanatized 16 weeks after inoculation, flukes were recovered, and the liver and other tissues were subjectively scored for the severity of lesions (0 to 4+). the number of flukes recovered from the clorsulon-treated group (3.8 +/- 1.2 ...	1988	3366676
preliminary report: immunodiagnosis of pre-type ii ostertagiasis.	ostertagia ostertagi soluble antigens were prepared by gel electrophoresis and electrophoretic transfer onto nitrocellulose for enzyme-linked immunosorbent assays with serum probes. serologic responses to l3-derived antigen of approximately 32 kda may be unique and diagnostic for cattle harboring inhibited larvae, or pre-type ii ostertagiasis. specificity was evaluated by comparing sera from pre-type ii cattle to sera from type i, uninfected, fascioloides magna infected, fasciola hepatica infect ...	1988	3363842
a natural infection of fascioloides magna in a llama (lama glama).	a young, female llama (lama glama) was euthanized following the onset of hindleg paresis and paralysis. live trematodes, identified as fascioloides magna, were identified from the liver of this animal. this represents the first report of f. magna in a llama.	1988	3357126
diseases of wapiti utilizing cattle range in southwestern alberta.	specimens from 28 wapiti (cervus elaphus canadensis) were collected by hunters in southwestern alberta in 1984. various tests were performed to detect infections and conditions that could affect cattle sharing the range or cause disease in wapiti. serum antibodies were present against leptospiral serovars autumnalis (25%), bratislava (4%), and icterohaemorrhagiae (8%), and the viruses of bovine virus diarrhea (52%), infectious bovine rhinotracheitis (45%), and parainfluenza type 3 (13%). no sero ...	1987	3029443
efficacy of triclabendazole against experimentally induced fascioloides magna infections in sheep.	efficacy of oral administration of 20 mg of triclabendazole/kg of body weight was evaluated against 12-week fascioloides magna infections in 12 sheep, each inoculated orally with 250 viable metacercariae. from 6 sheep treated with triclabendazole, 1 immature f magna was recovered, whereas 116 f magna with a mean length of 19 +/- 6.5 mm were recovered from 6 untreated control sheep. efficacy of triclabendazole was 99.14%. signs of toxicosis or illness were not observed in the sheep.	1989	2930033
efficacy of triclabendazole against fascioloidiasis (fascioloides magna) in naturally infected white-tailed deer (odocoileus virginianus).	the efficacy of triclabendazole was evaluated in the treatment of naturally acquired fascioloides magna infections in white-tailed deer (odocoileus virginianus). twenty white-tailed deer were captured on the welder wildlife refuge (sinton, san patricio county, texas, usa) and maintained in a 64 x 64 m deer enclosure. ten deer were given a 5% suspension of triclabendazole orally at a dosage of 10 mg/kg body weight and 10 deer were given a placebo. three wk later the deer were euthanized and exami ...	1989	2761011
restriction enzyme mapping of ribosomal dna can distinguish between fasciolid (liver fluke) species.	recognition sites for nine different restriction endonucleases were mapped on rdna genes of fasciolid species. southern blots of digested dna from individual worms were probed sequentially with three different probes derived from rdna of schistosoma mansoni and known to span between them the entire rdna repeat unit in that species. eighteen recognition sites were mapped for fasciola hepatica, and seventeen for fasciola gigantica and fascioloides magna. each fasciolid species had no more than two ...	1989	2552311
integrated control of fascioloides magna infection in northern italy.	the following study records ten years' experience in the control of fascioloides magna infection in a fenced area grazed by an overdense red deer population together with free-ranging cattle. during the winter 1977/78 mortality due to a "fascioloidosis-malnutrition syndrome" reduced the deer stock almost by half. control measures were aimed at combatting the fluke in the wild definitive host by the administration of medicated pellets. four flukicides were used over the years: rafoxanide, diamphe ...	1989	2486993
use of albendazole in feed to control fascioloides magna infections in captive white-tailed deer (odocoileus virginianus).	thirty-six adult white-tailed deer (odocoileus virginianus) naturally infected with fascioloides magna were captured and randomly assigned to four groups. each group was fed pelleted feed coated with albendazole for each of seven consecutive days to deliver the drug at a dose rate of approximately 0.0, 5.0, 8.5, or 16.5 mg/kg bodyweight/day. at 7 wk posttreatment, each animal was euthanized and necropsied. effects of albendazole treatment included significant reduction (p less than 0.05) in para ...	1990	2338728
survey of hepatic and pulmonary helminths of wild cervids in alberta, canada.	during the 1988 hunting season, livers and lungs from 263 mule deer (odocoileus hemionus hemionus), 198 moose (alces alces), 147 white-tailed deer (odocoileus virginianus), and 94 wapiti (cervus elaphus nelsoni) from alberta (canada) were collected for parasitological examination. most of the samples (89%) were submitted by big game hunters throughout the province. giant liver fluke (fascioloides magna) was found in 9% of 22 yearling and 29% of 65 adult wapiti; 4% of 161 adult moose; and 2% of 9 ...	1990	2250321
domestic sheep as a rare definitive host of the large american liver fluke fascioloides magna.	two domestic sheep were inoculated orally with 250 metacercariae of fascioloides magna. one sheep died 4 mo after inoculation and 22 immature f. magna were recovered. the second sheep remained healthy and was killed 8 mo after inoculation. ten mature f. magna were recovered from hepatic parenchyma, and eggs of f. magna were observed in areas of the liver where flukes resided and from feces. although f. magna is almost always lethal to sheep, this sheep was a rare definitive host.	1990	2213420
hematology and clinical pathology of experimental fascioloides magna infection in cattle and guinea pigs.	the hematologic and clinico-pathologic response to fascioloides magna infection in cattle and guinea pigs was investigated. twelve calves (six infected and six controls) were monitored for 26 weeks after inoculation with 1000 metacercariae. all calves remained healthy and there were no significant differences in weight gains between infected and control groups. flukes (mean = 9.2, range 1-32) were recovered from the liver and abdominal cavity of all infected calves. the only significant response ...	1991	1788931
production and characterization of monoclonal antibodies against excretory-secretory products of fasciola hepatica.	four monoclonal antibodies (mabs) (9.49, 24.27, 46.71 and 179.57) were produced against fasciola hepatica excretory-secretory products. isotype analysis revealed the antibodies to be igm, igg3, igg1, and igm. in immunoblot assays, the mabs recognized different antigenic polypeptides migrating between 29 and 180 kda. specificity of the mabs was evaluated by elisa against antigens of fascioloides magna, anoplocephala magna, stichorchis subtriquetrus, haemonchus contortus, sheep liver extract (sle) ...	1991	1788930
hepatic and pulmonary pathology of experimental fascioloides magna infection in guinea pigs.	the guinea pig was used to study the pathology of fascioloides magna, an important pathogen for sheep. although flukes migrated freely through various tissues in infected guinea pigs, the most serious lesions occurred in the liver and lungs. the sequential development of lesions indicated that flukes first invaded the quadrate lobe of the liver and subsequently migrated to other liver lobes and tissues. six weeks post-infection, there was a marked drop in the recovery of flukes from the liver al ...	1991	1779042
efficacy of triclabendazole against natural infections of fascioloides magna in wapiti.	fourteen free-ranging adult wapiti (cervus elaphus nelsoni) were captured in banff national park, alberta (canada) and held in captivity near edmonton. a 24% suspension of triclabendazole at doses of 30 to 100 mg/kg body weight was drenched into the rumen of eight females and four males. two male wapiti were used as untreated controls. animals were killed and examined at 4 (n = 3), 6 (n = 4), or 8 (n = 4) wk after treatment. efficacy was 90% against immature fascioloides magna collected 4 wk aft ...	1991	1758025
experimental fascioloides magna infections of mule deer (odocoileus hemionus hemionus).	six mule deer (odocoileus hemionus hemionus) and one white-tailed deer (odocoileus virginianus), approximately 5-mo-old, each were inoculated orally with 500 metacercariae of fascioloides magna. all mule deer died from liver fluke infection between 69 and 134 days (mean = 114, se = 9.9) after inoculation. between 38 and 326 immature f. magna (mean = 102, se = 45.5) were recovered from each deer at necropsy. flukes were present in livers, lungs, and free in pleural and peritoneal spaces. infectio ...	1992	1602568
isoelectric focusing of soluble proteins from fasciola hepatica l, 1758 and fascioloides magna b, 1875.	isoelectric focusing was performed on the soluble proteins of whole-body and excretory-secretory products (esp) of fasciola hepatica and fascioloides magna. adult f hepatica flukes were recovered from experimentally infected sheep and esp obtained from the flukes; portions of liver were cut and frozen at -70 c. fascioloides magna adults were collected from naturally infected white-tailed deer and esp obtained; portions of liver were collected from noninfected white-tailed deer. adult flukes and ...	1992	1575393
efficacy of two formulations of albendazole against liver flukes in cattle.	albendazole (10 mg/kg of body weight) was administered as a drench suspension or as a feed additive to 24 cattle with naturally acquired infections of fasciola hepatica and fascioloides magna. cattle were euthanatized 16 to 30 days after treatment, and the number of viable flukes was counted. viable f hepatica and f magna were decreased by 91.4% and 70.6% for drench administration and by 82.9% and 71.9% for the feed additive treatment, respectively. there was no significant difference between th ...	1992	1497187
epizootiology of fascioliasis in montana.	during 1989-1990, the united states department of agriculture (usda) meat inspection records were used to determine the distribution and incidence of liver flukes (fasciola hepatica and fascioloides magna) in montana cattle. of the cows and bulls slaughtered in usda-inspected packing plants during a 12 month time period, 17.24% had livers that were condemned because of liver flukes. this was a 12% increase over usda liver condemnations reported for 1973. infected animals have been reported from ...	1992	1496783
detection of stable diagnostic antigen from bile and feces of fasciola hepatica infected cattle.	diagnostic antigens in bile and feces from fasciola hepatica infected cattle were detected and characterized by enzyme-linked immunotransfer blot (eitb) techniques. as sources of antigen, samples of bile, intestinal contents and feces were collected from five uninfected calves and from 10 calves with known fasciola hepatica burdens. a band detected by eitb using a densitometer in the area corresponding to 26 kda reacted with rabbit anti-fresh fluke antigen and infected cattle sera but not with f ...	1992	1485418
development of the large american liver fluke, fascioloides magna, in white-tailed deer, cattle, and sheep.	the comparative development of fascioloides magna in white-tailed deer, cattle and sheep has been studied. flukes were recovered from 72% of 32 deer administered 40 to 500 metacercariae, from 82% of 11 cattle administered 10 to 500 metacercariae, and from 53% of 15 sheep administered 8 to 200 metacercariae. the percentage recovery of the flukes administered as metacercariae was 4.1% of 6,130 in deer, 5.7% of 2,510 in cattle, and 4.7% of 1,213 in sheep. flukes were recovered only from livers of i ...	1976	1255380
parenteral infection of white-tailed deer (odocoileus virginianus) with metacercariae of fasciola hepatica and fascioloides magna.		1976	1255364
fascioloides magna (bassi, 1875) in feral swine from southern texas.	between 1971 and 1975, fascioloides magna was found in 46 of 67 (69%) feral swine (sus scrofa) in southern texas. flukes were recovered from swine in areas where f. magna commonly has been recovered from white-tailed deer and cattle. one to 12 flukes were recovered from each infected animal. their presence was indicated by black hematin pigment on the liver and various other internal organs. eggs were not detected in the gallbladder or feces of infected animals although mature flukes and eggs we ...	1975	1195502
fascioloides magna infection in white-tailed deer of southeastern united states.	livers of 4,023 white-tailed deer (odocoileus virginianus) from 13 southeastern states were examined for flukes; 514 (12.8%) harbored fascioloides magna. other species of liver flukes were not found. forty-two nidi of infection were found, encompassing 56 counties in 9 states. as many as 125 flukes were recovered from a single deer. although f magna was widely distributed throughout southeastern united states, most enzootic areas were confined to the coastal plain physiographic province. since d ...	1977	924869
the penetration of fascioloides magna miracidia into the snail host fossaria bulimoides. a scanning electron microscope study.	snails of the species fossaria bulimoides were exposed to miracidia of fascioloides magna for given periods of time. the course of penetration was followed by means of scanning electron microscopy. topographical features of the miracidial morphology were studied; the apical organ, epidermal plates and their shedding, and body shapes during penetration. preliminary data were obtained concerning the nature of the lesions formed by the miracidia. inferences were drawn concerning the mode and durati ...	1977	888510
[clinical examination of the blood of red deer (cervus elaphus l.) naturally infested with parasites].	in six animals hunted and four immobilized animals of red deer (cervus elaphus l.) of both sexes and of different age, kept at three game preserves in bohemia, the psychological values were ascertained: the number of erythrocytes and leucocytes, the hemoglobin content, the hematocrit, mcv, mch, mchc, the white blood count, the total serum protein, the fractions: albumin, alpha-, beta- and gamma-globulin, the activity of sgot, and sgpt, the alkaline phosphatase and the metabolism of calcium, phos ...	1976	820034
anthelmintic activity of albendazole in white-tailed deer.	albendazole at dose rates of 11 to 54 mg/kg (mean of 25 +/- 11 sd) of body weight was highly effective (greater than 99%) against haemonchus contortus, ostertagia odocoilei, o mossi, trichostrongylus askivali and nematodirus odocoilei in 22 white tailed deer (odocoileus virginianus) in southern texas. it was 38% effective against mature and immature deer liver flukes (fascioloides magna). toxicoses associated with treatment were not observed. large numbers of abomasal nematodes (mean of 2,949 +/ ...	1978	749572
experimental infection of lymnaeid snails in wisconsin with miracidia of fascioloides magna and fasciola hepatica.		1978	739308
first report of fascioloides magna (bassi, 1875) in south africa.	fascioloides magna from a brahman heifer recently imported from the usa is recorded for the first time in south africa. the pathological findings are briefly described. the possibility of this parasite becoming established in this country is also discussed.	1977	614520
fascioloides magna in white-tailed deer (odocoileus virginianus): observations on the pairing tendency.	fascioloides magna (bassi 1875) was recovered from 227 of 312 (73%) white-tailed deer (odocoileus virginianus) in southern texas between 1971 and 1975. deer from age classes more than 1 year old had infection rates of from 64 to 84%. few dead flukes were found. flukes occurred exclusively in the livers of infected animals and were paired in 256 of 301 (85%) fibrous hepatic capsules. the prevalence of immature flukes with an average of one immature per infected liver was similar in all age classe ...	1977	592035
a controlled evaluation of albendazole against natural infections with fasciola hepatica and fascioloides magna in cattle.	albendazole administered to cattle at doses of 45, 35, 25, and 15 mg/kg of body weight reduced the number of viable fasciola hepatica adults by 99.8%, 97.6%, 97.6%, and 95.7%, f hepatica immatures by 100%, 98.6%, 98.6% and 91.9% and fascioloides magna by 96.5%, 99.1%, 94.0%, and 94.0%, respectively. statistical evaluation by one-way analysis of variance, showed significant (p less than 0.05) differences in burdens of each fluke species between treated and untreated cattle, but differences in eff ...	1979	525936
selected clinicopathologic changes associated with experimentally induced fascioloides magna infection in white-tailed deer.	six white-tailed deer (odocoileus virginianus), less than one year of age, were divided into two groups of three each and administered 50, or 500 metacercariae of ascioloides magna. all six deer became infected. three additional deer of the same age were uninoculated controls. all deer were monitored for up to 43 weeks after inoculation to investigate changes in weight, selected hematologic values, and blood chemistry values. although clinical disease was not evident in the infected deer, a sign ...	1979	459050
fascioloides magna: development in selected nonruminant mammalian hosts.		1979	108129