Publications

oleander toxicity: an examination of human and animal toxic exposures.	the oleander is an attractive and hardy shrub that thrives in tropical and subtropical regions. the common pink oleander, nerium oleander, and the yellow oleander, thevetia peruviana, are the principle oleander representatives of the family apocynaceae. oleanders contain within their tissues cardenolides that are capable of exerting positive inotropic effects on the hearts of animals and humans. the cardiotonic properties of oleanders have been exploited therapeutically and as an instrument of s ...	1996	8619248
larvicidal activity of a few plant extracts against culex quinquefasciatus and anopheles stephensi.	larvicidal activity of partially purified extracts of leaves of vitex negundo, nerium oleander and seeds of syzygium jambolanum on different instars of culex quinquefasciatus and anopheles stephensi was estimated. petroleum ether (pe): ethyl acetate (ea) 3:1 fraction of v. negundo, 1:1 fractions of n. oleander and s. jambolanum inflicted considerable larval mortality and interfered with pupal-adult metamorphosis. at very low concentration the active fractions of these plant extracts extended the ...	1995	8549835
beneficial effect of digoxin-specific fab antibody fragments in oleander intoxication.	a 24-year-old man presented to the emergency department with nausea, vomiting, abdominal pain, and an acute confusional state of 6 hours' duration. ten hours before admission, he had ingested a mixture of orange juice and six ground leaves, later identified as nerium oleander (common pink oleander) leaves. his blood pressure was 100/80 mm hg, and his pulse rate was irregular at 40/min. he was disoriented and his speech was dysarthric. twelve-lead electrocardiography revealed a complete atriovent ...	1995	7575073
transitory complete atrioventricular block associated to ingestion of nerium oleander.	self-medication with plants can lead to severe poisoning. oleander (nerium oleander) is an ornamental plant whose toxicity to man is due to a mixture of nondigitalis cardiac glycosides. the clinical manifestations of oleander poisoning combine cardiac and gastrointestinal symptoms, and are similar to those of a digitalis overdose.	1995	7550418
a case report of nerium oleander poisoning in cattle.	nerium oleander leaves caused the death within 36 hours of 7 of 17 cattle which had access to boughs of the plant. arrhythmia and auriculo-ventricular block at ecg were found in three cattle surviving on day 4. in one animal which died on day 4, postmortem examination revealed subendocardial and abomasal hemorrhages. epidermic tissues of the leaves of n oleander were found in the rumen content. recovery occurred in the three animals with marked cardiac signs.	1984	6540502
[studies on poisoning with nerium oleander l].		1971	5168850
toxicity of nerium oleander in the monkey (cebus apella).		1974	4219089
regulation of 3-indoleacetic acid production in pseudomonas syringae pv. savastanoi. purification and properties of tryptophan 2-monooxygenase.	the oxidative decarboxylation of l-tryptophan to yield 3-indoleacetamide, catalyzed by tryptophan 2-monooxygenase, represents a controlling reaction in the synthesis of indoleacetic acid by pseudomonas savastanoi (pseudomonas syringae pv. savastanoi), a gall-forming pathogen of olive (olea europea l.) and oleander (nerium oleander l.). production of indoleacetic acid is essential for virulence of the bacterium in its hosts. tryptophan 2-monooxygenase was characterized to determine its role in in ...	1985	3997822
oleander poisoning: treatment with digoxin-specific fab antibody fragments.	a 37-year-old man presented two hours after the ingestion of "a handful" of oleander leaves (probably nerium oleander) in a suicide attempt. cardiotoxicity was evidenced by the presence of bradycardia (rate, 30 to 45) with sinoatrial nodal arrest and junctional escape consistent with a cardiac glycoside effect. the patient was treated empirically with a single dose of five vials (200 mg) of digoxin-specific fab antibody fragments (digibind). the pretreatment digoxin level was 1.5 ng/ml. after tr ...	1988	3382077
[effect of several extracts derived from plants on the survival of larvae of aedes fluviatilis (lutz) (diptera: culicidae) in the laboratory].	the larvicidal properties of 34 plant extracts were tested against aedes fluviatilis (lutz) (diptera: culicidae) larvae, at 100, 10 and 1 ppm concentrations; 26.6% of the extracts enhanced larval mortality (alpha = 0.05) at 100 ppm (anacardium occidentale, agave americana, allium sativum, coriandrum sativum, nerium oleander, spatodea campanulata, tibouchina scrobiculata and vernonia salzmanni). anacardic acid (a. occidentale) was effective at 10 ppm and a. sativum (crude extract) at 1 ppm.	2006	3249563
naturally occurring cardiac glycosides.	cardiac glycoside poisoning from the ingestion of plants, particularly of oleanders, occurs with reasonable frequency in tropical and subtropical areas. we have assessed a variety of plant specimens for their cardiac glycoside content by means of radioimmunoassays with antibodies that differ in their specificity for cardiac glycosides. significant amounts of immunoreactive cardiac glycoside were found to be present in the ornamental shrubs: yellow oleander (thevetia peruviana); oleander (nerium ...	1986	3086679
detection of poisoning by plant-origin cardiac glycoside with the abbott tdx analyzer.	cardiac glycoside poisoning caused by ingestion of plant material is common in tropical and sub-tropical areas. in evaluating the use of the abbott tdx digoxin ii assay to detect such cases of poisoning, we found it a rapid and convenient method for confirming the ingestion of glycosides from the plants nerium oleander, thevetia peruviana, and adonis microcarpa, and from the toad bufo marinus. here we report some clinical cases illustrating our experience with the use of this assay, and describe ...	1989	2914377
digoxin-specific fab fragments in the treatment of oleander toxicity in a canine model.	to examine the efficacy of digoxin-specific fab fragments (dsfab) in the treatment of experimentally induced nerium oleander cardiac glycoside toxicity in a dog model.	1991	1928877
evaluation of selected plants for acute toxicosis in budgerigars.	pairs of budgerigars were given samples, by gavage, of plants considered potentially toxic to pet birds. samples were prepared by flash-freezing and powdering fresh plant material in liquid nitrogen and resuspending the material in deionized water for administration. of the 19 plants tested, only 6 induced clinical signs of illness; these plants included yew, oleander, clematis, avocado, black locust, and virginia creeper (taxus media, nerium oleander, clematis sp, persea americana, robinia pseu ...	1992	1577644
oleander poisoning.	the two common oleanders, thevetia peruviana and nerium oleander, contain a mixture of poisons including cardiac glycosides, and are extremely toxic. they are cultivated universally throughout australia, and rank equally with mushrooms as the major cause of children's admission to hospital after accidental plant ingestions. a seven-year total population survey from south-east queensland has revealed that, in practice, the rate of clinical poisoning due to oleander is inconsequential, and mortali ...	2001	92752