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concomitance and interactions of pathogens in the iberian wolf (canis lupus).with the aim of improving our understanding of their epidemiological features, exposure to or presence of canine parvovirus (cpv), canine distemper virus (cdv), leishmania infantum and sarcoptes scabiei were studied in 88 wild wolves from asturias (northern spain) by means of long-term (2004-2010) serological and molecular data. individual and population factors and the possible interactions between them were also statistically analyzed for better understanding the contact/presence of studied pa ...201526267084
efficacy assessment of biocides or repellents for the control of sarcoptes scabiei in the environment.sarcoptes scabiei infection is a contagious disease affecting both humans and animals. the transmission occurs either by direct contact or from the environment where mites could survive several days remaining infective. the number of products available for environmental control of s. scabiei is very limited. the objective of the present study was to assess the efficacy of biocides or repellents against s. scabiei var suis.201526259713
acute phase proteins increase with sarcoptic mange status and severity in iberian ibex (capra pyrenaica, schinz 1838).sarcoptic mange is a contagious skin disease caused by sarcoptes scabiei, affecting both domestic and wild mammals, including the iberian ibex (capra pyrenaica), a medium-sized mountain ungulate almost endemic to the iberian peninsula. acute phase proteins (apps) could be an indicator of sarcoptic mange disease and severity in iberian ibex. serum samples from 131 healthy and sarcoptic mange-affected iberian ibexes were collected from 2005 to 2012 in sierra nevada natural space in southern spain. ...201526227139
acaricidal activity of extracts from ligularia virgaurea against the sarcoptes scabiei mite in vitro.the aim of the present study was to investigate the acaricidal activity of ligularia virgaurea. an extract was prepared by refluxing with ethanol and steam distillation, and its toxic effect was tested in vitro against sarcoptes scabiei. the data from the toxicity tests were analyzed using a complementary log-log (cll) model. the ethanol extract exhibited strong acaricidal activity against these mites; at a concentration of 2 g/ml it killed all s. scabiei within 2 h and at 1 g/ml it killed all s ...201526170943
coexistence of two different genotypes of sarcoptes scabiei derived from companion dogs and wild raccoon dogs in gifu, japan: the genetic evidence for transmission between domestic and wild canids.sarcoptes scabiei is the causal agent of sarcoptic mange in domestic/companion dogs (canis lupus familiaris) and raccoon dogs (nyctereutes procyonoides). although there have been successful cases of experimental transmission of s. scabiei from mangy wild canidae hosts to healthy dogs, and suspected cases of transmission between raccoon dogs and companion dogs, no clear-cut evidence has been obtained. in the present study, the genetic relationships between sarcoptes mites from raccoon dogs and co ...201526165631
evaluation of a commercial elisa for the detection of antibodies to sarcoptes scabiei in wild boar (sus scrofa).sarcoptic mange occurs in free-ranging wild boar (sus scrofa) but has been poorly described in this species. we evaluated the performance of a commercial indirect enzyme-linked immunosorbent assay (elisa) for serodiagnosis of sarcoptic mange in domestic swine when applied to wild boar sera. we tested 96 sera from wild boar in populations without mange history ("truly noninfected") collected in switzerland between december 2012 and february 2014, and 141 sera from free-ranging wild boar presentin ...201526161723
reflectance confocal microscopy in infectious diseases.in vivo reflectance confocal microscope (rcm) is a high-resolution non-invasive imaging technique that was initially focused on the diagnosis of skin cancers. a rising number of other indications have been later described for the diagnosis and management of inflammatory and infectious dermatological disorders. rcm can identify cutaneous parasites that are not visible to naked eye such as sarcoptes scabiei and demodex folliculorum and it allows to better identify the different body parts of bigge ...201526129682
bullous scabies: a case report and review of the literature.scabies is a common parasitic infection caused by the mite sarcoptes scabiei. about 300 million cases of scabies are reported annually. scabies usually presents clinically with an erythematous excoriated papulovesicular rash, burrows, nodules and hyperkeratotic lesions in specific body areas. a rare presentation of scabies is the bullous pemphigoid-like bullous scabies. so far, to the best of our knowledge, only 32 cases of bullous scabies have been reported in medical literature, of which only ...201526092057
treatment of mange infection in a weaner flock of sheep with ivermectin at sheep breeding farm hardishiva of kashmir valley.an outbreak of sarcoptes scabiei mange occured in a weaner flock that comprised of 74 animals including 31 male and 43 female at sheep breeding farm hardishiva of kashmir valley. all the animals in the flock were affected. animals were very weak and emaciated skin lesions were confined to the lips, nostrils, ears, face, and were characterized by pruritus, erythema, papule formation, alopecia and scab formation. microscopic examination of skin scraping revealed s. scabiei mange infestation. the a ...201526063994
parasites of pigs in two farms with poor husbandry practices in bishoftu, ethiopia.a cross-sectional study was conducted from november 2011 to april 2012 on a total of 384 pigs from two privately owned intensive farms in bishoftu, ethiopia. the objectives of the study were to identify and determine the prevalence of common parasites of pigs. for the determination of gastrointestinal (git) parasites, faecal samples were collected from the study animals and subjected to standard parasitological examination techniques. physical examination was conducted for the presence of skin p ...201526017194
first detection of sarcoptes scabiei from domesticated pig (sus scrofa) and genetic characterization of s. scabiei from pet, farm and wild hosts in israel.in this report we describe for the first time the detection of sarcoptes scabiei type suis mites on domestic pigs in israel and examine its genetic variation compared with s. sabiei from other hosts. microscopic examination of skin samples from s. scabiei-infested pigs (sus scrofa domesticus) revealed all developmental stages of s. scabiei. to detect genetic differences between s. scabiei from different hosts, samples obtained from pig, rabbits (orictolagus cuniculus), fox (vulpes vulpes), jacka ...201526002310
social living mitigates the costs of a chronic illness in a cooperative carnivore.infection risk is assumed to increase with social group size, and thus be a cost of group living. we assess infection risk and costs with respect to group size using data from an epidemic of sarcoptic mange (sarcoptes scabiei) among grey wolves (canis lupus). we demonstrate that group size does not predict infection risk and that individual costs of infection, in terms of reduced survival, can be entirely offset by having sufficient numbers of pack-mates. infected individuals experience increase ...201525983011
in vitro acaricidal activity of 1,8-cineole against sarcoptes scabiei var. cuniculi and regulating effects on enzyme activity.1,8-cineole found in many essential oils is a monoterpene and acts as a repellent against sarcoptes scabiei var. cuniculi. in the present study, the acaricidal activity of 1,8-cineole against s. scabiei var. cuniculi was evaluated and the acaricidal mechanism was also investigated by assaying enzyme activities. the results showed that the lethal concentration of 50% (lc50) value (95% confidence limit (cl)) and the lethal time of 50% (lt50) value (95% cl) of 1,8-cineole were 2.77 mg/ml and 3.606 ...201525924796
development of conventional and real-time quantitative pcr assays for diagnosis and monitoring of scabies.scabies remains the most prevalent, endemic, and neglected ectoparasitic infestation globally and can cause institutional outbreaks. the sensitivity of routine microscopy for demonstration of sarcoptes scabiei mites or eggs in skin scrapings is only about 50%. except for three studies using conventional or two-tube nested pcr on a small number of cases, no systematic study has been performed to improve the laboratory diagnosis of this important infection. we developed a conventional and a real-t ...201525903566
poor health is associated with use of anthropogenic resources in an urban carnivore.rates of encounters between humans and wildlife are increasing in cities around the world, especially when wildlife overlap with people in time, space and resources. coyotes (canis latrans) can make use of anthropogenic resources and reported rates of conflict have increased in cities across north america. this increase may be linked to individual differences in the use of human food and developed areas. we compared the relationships between coyote age, sex or health and the use of anthropogenic ...025876843
an elderly long-term care resident with crusted scabies.crusted scabies is a highly contagious form of scabies. altered immune response, nutritional deficiencies and modified host response are all risk factors for crusted scabies. the authors report a case involving a patient found to have a chronic maculopapular, erythematous rash with large hyperkeratotic, white and grey plaques on the soles of both feet. an ultimate diagnosis of crusted scabies was reached after a delay in diagnosis suspected to be caused by the similarity in appearance to more co ...201725798153
superficial fibrin thrombi … and other findings: a review of the histopathology of human scabietic infections.cutaneous infection with the mite sarcoptes scabiei var. hominis is associated with epidermal and dermal changes. after noting superficial fibrin thrombi in two biopsies with scabies mites, we comprehensively reviewed the histopathologic findings in scabietic infections to determine the frequency of this finding.201525754497
prospective study in a porcine model of sarcoptes scabiei indicates the association of th2 and th17 pathways with the clinical severity of scabies.understanding of scabies immunopathology has been hampered by the inability to undertake longitudinal studies in humans. pigs are a useful animal model for scabies, and show clinical and immunologic changes similar to those in humans. crusted scabies can be readily established in pigs by treatment with the glucocorticoid dexamethasone (dex).201525730203
[scabies as an occupational disease].scabies is an infectious skin disease caused by the human itch mite (sarcoptes scabiei var. hominis). it is mainly transmitted by direct skin-to-skin contact. the spread of scabies can cause major difficulties in healthcare institutions, particularly in residential homes for the elderly. the disease is characterized by intense nocturnal itching, erythematous papules arranged in a linear order, and scratching resulting in excoriations. the diagnosis is confirmed by identification of the mite or b ...201525676574
sarcoptic mange in captive maras: the first known outbreak and complete recovery with colony-wide acaricide treatment.among 16 maras housed as a colony at a zoo, 2 initially showed generalized dermal lesions on the legs, head and abdomen. approximately 1 month later, following completion of therapy with amitraz, 6 maras in the same colony, including the 2 previously diseased animals, showed dermal lesions with severe alopecia and crusting. sarcoptic mange was diagnosed on skin scrapings on the basis of morphological criteria. the mites were highly mobile and abundant in all cases, and no other causative agents ...201525648673
study on mange mite of camel in raya-azebo district, northern ethiopia.a cross-sectional study was carried out to determine the prevalence and species of camel mange mite infestation in raya-azebo district, northern part of ethiopia. accordingly, three hundred and eighty-four camels were examined and mange mite infestation was detected on 64 of camels. only sarcoptes scabiei var. cameli was identified as the only mite species in all skin scraping samples collected from the suspected mange mite lesions. there was significant difference in the prevalence of mange mit ...201425568694
assessment of the cytokine profile in peripheral blood mononuclear cells of naturally sarcoptes scabiei var. canis infested dogs.the mechanism of cytokine secretion from t lymphocytes plays an important role in the immune response of dogs and parasitic skin infestations. assessment of the cytokine profile of naturally s. scabiei var. canis infested dogs could augment understanding of the pathobiology of canine sarcoptic mange. therefore, the present study examined the cytokines in peripheral blood mononuclear cells of dogs suffering from sarcoptic mange. thirteen dogs naturally infected with sarcoptic mange participated i ...201425468023
exodus of sarcoptes scabiei var. hominis from the threatening blade of homo sapiens. 201425437988
treatment and control of bovine sarcoptic and psoroptic mange infestation with ivermectin long-acting injectable (ivomec(®) gold).the efficacy of ivermectin long-acting injection (ivm lai, ivomec® gold, merial; 3.15 % ivermectin w/v) formulation was evaluated in cattle with induced sarcoptes scabiei var. bovis or psoroptes ovis infestations. a total of 64 cattle were included in this series of four studies, with 16 animals per study. approximately, 8 weeks following initial induced mite infestation, cattle were allocated to treatment groups based on decreasing pre-treatment bodyweights. treatments (saline (control) or ivm ...201525399813
involvement of two genetic lineages of sarcoptes scabiei mites in a local mange epizootic of wild mammals in japan.similar to wild mammals on the continents, mange caused by the mange mite, sarcoptes scabiei (acari: sarcoptidae) is spreading in wild mammals in most of japan. we collected crusted or alopetic skin from 120 raccoon dogs (nyctereutes procyonoides viverrinus), three raccoons (procyon lotor), six japanese badgers (meles anakuma), one japanese marten (martes melampus), one stray dog (canis lupus familiaris), four wild boars (sus scrofa leucomystax), and one japanese serow (capricornis crispus), mai ...201525397999
distinguishing disease effects from environmental effects in a mountain ungulate: seasonal variation in body weight, hematology, and serum chemistry among iberian ibex (capra pyrenaica) affected by sarcoptic mange.our study focuses on the iberian ibex (capra pyrenaica) from the sierra nevada natural space (southern spain), where sarcoptic mange is an endemic disease and animals are affected by a highly seasonal environment. our aim was to distinguish between disease and environmental influences on seasonal variation in body weight, hematology, and serum biochemistry in iberian ibex. we sampled 136 chemically immobilized male ibexes. the single effect of mange influenced hemoglobin, hematocrit, mean corpus ...201525380360
inefficacy of alcohol-based hand rub on mites in a patient with hyperkeratotic scabies.the world health organization is strongly promoting alcohol-based hand rubs to interrupt transmission of pathogens within the healthcare environment, and in some hospitals they are being recommended in cases of scabies. however, there are no studies that demonstrate the efficacy of such hand rubs against scabies.201525251891
detailed analysis of in vivo reflectance confocal microscopy for sarcoptes scabiei hominis. 201525211585
genetic epidemiology and pathology of raccoon-derived sarcoptes mites from urban areas of germany.the raccoon, procyon lotor (carnivora: procyonidae), is an invasive species that is spreading throughout europe, in which germany represents its core area. here, raccoons mostly live in rural regions, but some urban populations are already established, such as in the city of kassel, or are starting to build up, such as in berlin. the objective of this study was to investigate sarcoptes (sarcoptiformes: sarcoptidae) infections in racoons in these two urban areas and to identify the putative origi ...201425171612
[diagnosis and evolution of scabies].human scabies is an ectoparasitosis affecting any individual at any age. the level of infestation by sarcoptes scabiei var. hominis is influenced by any defect in immune response. several clinical types of scabies are described including baby scabies, profuse scabies of immunodepression, norvegian scabies and sarcoptic mange. onchocerciasis dermatitis is a tropical microfilariosis completely distinct by its parasitic nature.201525158389
the parasitic fauna of the european bison (bison bonasus) (linnaeus, 1758) and their impact on the conservation. part 1. the summarising list of parasites noted.during the current century, 88 species of parasites have been recorded in bison bonasus. these are 22 species of protozoa (trypanosoma wrublewskii, t. theileri, giardia sp., sarcocystis cruzi, s. hirsuta, s. hominis, s. fusiformis, neospora caninum, toxoplasma gondii, cryptosporidium sp., eimeria cylindrica, e. subspherica, e. bovis, e. zuernii, e. canadensis, e. ellipsoidalis, e. alabamensis, e. bukidnonensis, e. auburnensis, e. pellita, e. brasiliensis, babesia divergens), 4 trematodes species ...201425119348
autoantibodies to iron-binding proteins in pigs infested with sarcoptes scabiei.despite the availability of effective treatments, sarcoptes scabiei remains a major health problem in the pig industry. unsuccessful control of the disease is often due to the lack of reliable detection methods, with current tests relying on skin scrapings and crude antigen elisas. a previous analysis of antigens in pig skin scrapings reported that anti-transferrin antibodies were present in s. scabiei infected animals and that this finding might be considered as a useful diagnostic tool. this p ...201425085772
parasitic scabies mites and associated bacteria joining forces against host complement defence.scabies is a ubiquitous and contagious skin disease caused by the parasitic mite sarcoptes scabiei epidemiological studies have identified scabies as a causative agent for secondary skin infections caused by staphylococcus aureus and streptococcus pyogenes. this is an important notion, as such bacterial infections can lead to serious downstream life-threatening complications. as the complement system is the first line of host defence that confronts invading pathogens, both the mite and bacteria ...201425081184
crusted scabies is associated with increased il-17 secretion by skin t cells.scabies is an ectoparasitic infestation by the mite sarcoptes scabiei. although commonly self-limiting, a fraction of patients develop severely debilitating crusted scabies. the immune mechanisms underlying the development of crusted scabies are unclear, and undertaking longitudinal infection studies in humans is difficult. we utilized a porcine model to compare cellular immune responses in peripheral blood and skin of pigs with different clinical manifestations of scabies (n = 12), and in uninf ...201425040151
assay of alterations in oxidative stress markers in pigs naturally infested with sarcoptes scabiei var. suis.the present study aimed to examine the status of antioxidant systems of the pigs naturally suffering from sarcoptic mange. fifty nine pigs were divided into three groups, healthy control (group i, n=15), subclinical sarcoptic mange (group ii, n=22) and clinical sarcoptic mange (group iii, n=22). to assess the status of antioxidant systems; lipid peroxides (lpo), reduced glutathione (gsh), superoxide dismutase (sod), glutathione peroxidase (gpx), ascorbic acid, zinc and copper concentrations in t ...201424986463
studies on the acaricidal mechanism of the active components from neem (azadirachta indica) oil against sarcoptes scabiei var. cuniculi.octadecanoic acid-3,4-tetrahydrofuran diester, isolated from neem (azadirachta indica) oil, exhibited potent acaricidal activity against sarcoptes scabiei var. cuniculi. in this paper, the acaricidal mechanism of octadecanoic acid-3,4-tetrahydrofuran diester against sarcoptes scabiei var. cuniculi was evaluated based on pathologic histology and enzyme activities. the results showed that after compound treatment for 24h at a concentration of 20mg/ml, the lesions of mites were prominent under tran ...201424974121
a scabies mite serpin interferes with complement-mediated neutrophil functions and promotes staphylococcal growth.scabies is a contagious skin disease caused by the parasitic mite sarcoptes scabiei. the disease is highly prevalent worldwide and known to predispose to secondary bacterial infections, in particular by streptococcus pyogenes and staphylococcus aureus. reports of scabies patients co-infected with methicillin resistant s. aureus (mrsa) pose a major concern for serious down-stream complications. we previously reported that a range of complement inhibitors secreted by the mites promoted the growth ...201424945501
scabies mites alter the skin microbiome and promote growth of opportunistic pathogens in a porcine model.the resident skin microbiota plays an important role in restricting pathogenic bacteria, thereby protecting the host. scabies mites (sarcoptes scabiei) are thought to promote bacterial infections by breaching the skin barrier and excreting molecules that inhibit host innate immune responses. epidemiological studies in humans confirm increased incidence of impetigo, generally caused by staphylococcus aureus and streptococcus pyogenes, secondary to the epidermal infestation with the parasitic mite ...201424875186
scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway.scabies is an infectious skin disease caused by the mite sarcoptes scabiei and has been classified as one of the six most prevalent epidermal parasitic skin diseases infecting populations living in poverty by the world health organisation. the role of the complement system, a pivotal component of human innate immunity, as an important defence against invading pathogens has been well documented and many parasites have an arsenal of anti-complement defences. we previously reported on a family of s ...201424854034
parasitic infections based on 320 clinical samples submitted to hanyang university, korea (2004-2011).we analyzed 320 clinical samples of parasitic infections submitted to the department of environmental biology and medical parasitology, hanyang university from january 2004 to june 2011. they consisted of 211 nematode infections, 64 trematode or cestode infections, 32 protozoan infections, and 13 infections with arthropods. the nematode infections included 67 cases of trichuriasis, 62 of anisakiasis (anisakis sp. and pseudoterranova decipiens), 40 of enterobiasis, and 24 of ascariasis, as well a ...201424850969
effective treatment for improving the survival rate of raccoon dogs infected with sarcoptes scabiei.sarcoptes scabiei is one of the important external parasites. although ivermectin is the recommended treatment, many raccoon dogs (nyctereutes procyonoides) that were rescued and brought to the kanazawa zoological gardens (yokohama, japan) have died because of s. scabiei, even after receiving single ivermectin treatment. therefore, supportive treatment should be required. the present study revealed the number of animals that survived was greater after the administration of ivermectin along with ...201424813465
the efficacy of permethrin 5% vs. oral ivermectin for the treatment of scabies.human scabies is caused by an infestation of the skin by the human itch mite (sarcoptes scabiei var. hominis). the aim of this study is to compare the efficacy and safety of permethrin 5% lotion with oral ivermectin for the treatment of scabies. in total, 60 patients with scabies were enrolled, and randomized into two groups: the first group and their family contacts received 5% permethrin cream twice with a one week interval, and the other received a single dose of oral ivermectin. treatment wa ...201324791346
prevalence of sarcoptes scabiei infection in pet dogs in southern china.little is known about the prevalence of sarcoptes scabiei infection in pet dogs in china. in the present study, the prevalence of s. scabiei infection in pet dogs in guangzhou, southern china, was investigated between january and december, 2009. a total of 3,977 pet dogs admitted to animal hospitals were examined for the presence of s. scabiei using a parasitological approach. the average prevalence of s. scabiei infection in pet dogs is 1.18% (95% confidence interval (ci): 0.85-1.52%). the prev ...201424741355
[sarcoptic mange: report of an outbreak in a family and their pet].scabies caused by the genus sarcoptes scabiei var canis is a prevalent infection in dogs and affects abandoned, malnourished and overcrowded animals, causing hair loss and an intensely pruritic crusting dermatitis. in humans the manifestation is a self-limiting pruritic dermatitis, but persistent cases are described. an outbreak of sarcoptic mange is reported in a family group (seven people, including a 5 month infant and his mother). the infective source was their own house dog who was taken fr ...201424740774
immune response induced by candidate sarcoptes scabiei var. cuniculi dna vaccine encoding paramyosin in mice.sarcoptes scabiei is the causal agent of the highly contagious disease sarcoptic mange (scabies) that affects animals and humans worldwide. an increasing number of cases of treatment failure is being reported because of drug resistance. the development of a specific vaccine would be a sustainable option for control of this disease. in this study, we cloned and expressed a s. scabiei gene encoding paramyosin (par) and investigated the immune response elicited by dna encoding par in mice. the abil ...201424729069
preliminary molecular characterizations of sarcoptes scaibiei (acari: sarcoptidae) from farm animals in egypt.little is known about the genetic diversity of sarcoptes scabiei mites in farm animals in egypt. in this study, we characterized s. scabiei in 25 skin scrapes from water buffalo, cattle, sheep, and rabbits at the nuclear marker its2 and mitochondrial markers cox1 and 16s rrna. sequences of the its2 showed no host segregation or geographical isolation, whereas those of the mitochondrial cox1 and 16s rrna genes indicated the presence of both host-adapted and geographically segregated populations o ...201424728386
abul- hasan al-tabari: a review of his views and works.abul-hasan al-tabari was a 10th century persian physician born in tabaristan. he was a creative and innovative physician who avoided emulating treatments without investigating and examining them. tabari was an encyclopedist and had a holistic view to medicine. investigation of the views of this great persian scholar indicated that his scientific and moral characteristics contain: paying adequate attention to philosophy and medical ethics, citing other scholars' works, attention to the necessity ...201424724609
isolated itching of the genitals.a 38-year-old man, returned from ivory coast 2 months ago and presented with a 3-month history of pruritus exclusively on the scrotum. itching was continuous during the day and no pruritus was described in his wife and son. clinical examination of the genitals revealed several nodules on the scrotum, a chancrous lesion was seen on the penis, and multiple excoriations were noted. dermoscopy exam with a dermatoscope of the whole body was performed and no papules, nodules, or burrow were found. mic ...201424696404
primary and secondary experimental infestation of rabbits (oryctolagus cuniculus) with sarcoptes scabiei from a wild rabbit: factors determining resistance to reinfestation.studies of sarcoptic mange and immunity are hampered by lack of mite sources and natural infestation models. we have investigated the clinical and pathological signs, specific igg response and acquired immunity in naïve new zealand white rabbits (oryctolagus cuniculus) experimentally infested with sarcoptes scabiei originally isolated from a clinically affected free-living european wild rabbit. twenty rabbits were infested using two methods, direct contact for a 24 h period with a seeder rabbit ...201424690250
acaricidal activity of 9-oxo-10,11-dehydroageraphorone extracted from eupatorium adenophorum in vitro.the acaricidal activity of the 9-oxo-10,11-dehydroageraphorone (euptox a), a cadenine sesquiterpene from eupatorium adenophorum (e. adenophorum) against sarcoptes scabiei and psoroptes cuniculi was tested in vitro. a complementary log-log (cll) model was used to analyze the data of the toxicity tests in vitro. the results showed euptox a had strong toxicity against mites, killing all s. scabiei at 3 and 4 mg/ml (m/v) concentration, while 4 mg/ml euptox a was also found to kill all p. cuniculi wi ...201424631419
control of scabies outbreaks in an italian hospital: an information-centered management strategy.scabies is a dermatologic infestation caused by sarcoptes scabiei. in industrialized countries, hospitals and other health structures can sometimes be hit. the optimal management of scabies outbreaks still has to be established, mass prophylaxis being one possible option.201424581020
infections with cardiopulmonary and intestinal helminths and sarcoptic mange in red foxes from two different localities in denmark.monitoring parasitic infections in the red fox is essential for obtaining baseline knowledge on the spread of diseases of veterinary and medical importance. in this study, screening for cardiopulmonary and intestinal helminths and sarcoptic mange (sarcoptes scabiei) was done on 118 foxes originating from two distinct localities in denmark, (copenhagen) greater area and southern jutland. fifteen parasite species were recorded in 116 foxes (98.3%), nine parasitic species are of zoonotic potential. ...201424570055
interventions for preventing the spread of infestation in close contacts of people with scabies.scabies, caused by sarcoptes scabiei variety hominis or the human itch mite, is a common parasitic infection. while anyone can become infected, it causes significant morbidity in immunocompromised hosts and it spreads easily between human hosts where there is overcrowding or poor sanitation. the most common symptom reported is itch which is worse at night. as the symptoms are attributed to an allergic reaction to the mite, symptoms usually develop between four to six weeks after primary infectio ...201424566946
vaccine against scabies: necessity and possibility.scabies is an infectious disease that is endemic in poorly resourced communities, and also common in industrialized countries. although the disease, which is caused by infestation of sarcoptes scabiei, is generally mild, the need for a vaccine against s. scabiei is proposed. the immunological mechanisms that control s. scabiei infection are discussed and the current status of scabies vaccine development reviewed. future directions for scabies vaccine development are also addressed.201424476932
validation of pcr assay for identification of sarcoptes scabiei var. hominis.infestation of the skin by the "itch mite" sarcoptes scabiei var. hominis results in a contagious skin infection in humans called "scabies". by resolving morphology issues, the present study was designed to be acquainted with itch mite by molecular markers.201324454438
therapeutic management of sarcoptic mange in a sheep flock.sarcoptic mange infested sheep showed pruritis, excoriation, crusts, lichenification and secondary alopecia on face and ears. all the infested sheep were treated successfully with ivermectin at 200 μg/kg body weight and complete recovery of skin was observed between 10th and 14th day post treatments. sarcoptic mange is highly contagious and the spread of sarcoptes scabiei is usually by close contact but in goats not same because it has natural resistance against sheep mange.201324431584
advances in studies of disease-navigating webs: sarcoptes scabiei as a case study.the discipline of epidemiology is the study of the patterns, causes and effects of health and disease conditions in defined anima populations. it is the key to evidence-based medicine, which is one of the cornerstones of public health. one of the important facets of epidemiology is disease-navigating webs (disease-nw) through which zoonotic and multi-host parasites in general move from one host to another. epidemiology in this context includes (i) classical epidemiological approaches based on th ...201424406101
norwegian crusted scabies: an unusual case presentation.scabies is a contagious condition that is transmitted through direct contact with an infected person and has been frequently associated with institutional and healthcare-facility outbreaks. the subtype norwegian crusted scabies can masquerade as other dermatologic diseases owing to the heavy plaque formation. successful treatment has been documented in published reports, including oral ivermectin and topical permethrin. few case studies documenting the treatment of norwegian crusted scabies have ...201624370484
bullous scabies in an adult: a case report with review of literature.scabies is an infestation caused by sarcoptes scabiei, characterized by polymorphous lesions that may include burrows, papules, nodules, excoriation, and crusts. vesicular and bullous lesions are rather rare. bullous scabies is regarded as a distinct subtype of scabies, closely resembling bullous pemphigoid. here, we report a case of bullous scabies in an adult male and review the literature.201324350014
an aspartic protease of the scabies mite sarcoptes scabiei is involved in the digestion of host skin and blood macromolecules.scabies is a disease of worldwide significance, causing considerable morbidity in both humans and other animals. the scabies mite sarcoptes scabiei burrows into the skin of its host, obtaining nutrition from host skin and blood. aspartic proteases mediate a range of diverse and essential physiological functions such as tissue invasion and migration, digestion, moulting and reproduction in a number of parasitic organisms. we investigated whether aspartic proteases may play role in scabies mite di ...201324244770
[diagnosis of scabies by high-magnification dermoscopy: the "delta-wing jet" appearance of sarcoptes scabiei]. 201324206810
case for diagnosis.human scabies is an intensely pruritic skin infestation caused by sarcoptes scabiei var. hominis. crusted scabies (previously known as norwegian scabies) is a rare form, very contagious and transmitted by direct contact with the skin. despite being readily treatable, a delayed diagnosis often leads to widespread infestation of contacts, and therefore difficult to restrain. this case concerns a patient where dermoscopy (with scabetic burrows and a visible hand-glider structure), together with dir ...201524173196
treatment of scabies: the topical ivermectin vs. permethrin 2.5% cream.human scabies is caused by an infestation of the skin by the human itch mite (sarcoptes scabiei va. hominis). it is commonly treated with topical insecticides, but the treatment of choice is still controversial. the aim of this study is to compare the efficacy of topical ivermectin vs. permethrin 2.5% cream for the treatment of scabies. in total, 380 patients with scabies were enrolled, and randomized into two groups: the first group received 1% ivermectin applied topically to the affected skin ...201324171301
crusted scabies misdiagnosed as erythrodermic psoriasis in a 3-year-old girl with down syndrome.scabies is a highly contagious infestation with the sarcoptes scabiei var hominis mite. the variety of clinical presentations make timely, accurate diagnosis problematic. we report the case of a 3-year-old girl with down syndrome and crusted scabies initially misdiagnosed as erythrodermic psoriasis.201424138478
scalp involvement by sarcoptes scabiei var hominis resembling seborrhoeic dermatitis in two immunocompromised patients with systemic lupus erythematosus.scabies is a common condition in new zealand but scalp infestation by the mite is not often considered. topical treatments traditionally do not involve the scalp. we report two cases of immunocompromised patients with systemic lupus erythematosus (sle) who had scalp infestation clinically mimicking seborrhoeic dermatitis.201324126752
a novel clinical grading scale to guide the management of crusted scabies.crusted scabies, or hyperinfestation with sarcoptes scabiei, occurs in people with an inadequate immune response to the mite. in recent decades, data have emerged suggesting that treatment of crusted scabies with oral ivermectin combined with topical agents leads to lower mortality, but there are no generally accepted tools for describing disease severity. here, we describe a clinical grading scale for crusted scabies and its utility in real world practice.201324069468
acaricidal properties of an ailanthus altissima bark extract against psoroptes cuniculi and sarcoptes scabiei var. cuniculi in vitro.the potential acaricidal properties of an ailanthus altissima bark extract were assessed against two common species of animal ectoparasitic mites, psoroptes cuniculi and sarcoptes scabiei var. cuniculi, in vitro. a. altissima bark extract was obtained by ethanol thermal circumfluence and tested at four concentrations (1.0, 0.5, 0.25 and 0.125 g/ml) on mites collected from rabbits. compared to the fenvalerate treatment group, the a. altissima bark exhibited significant acaricidal properties for b ...201424052400
molecular survey of knockdown resistance to pyrethroids in human scabies mites.there are growing concerns about the emergence of resistance of sarcoptes scabiei to permethrin and other pyrethroid derivatives. sarcoptes scabiei mites collected from 40 patients visiting two hospitals near paris, france, were genotypically characterized considering two parts of their voltage-sensitive sodium channel gene. no nucleotide polymorphism resulting in a codon change at codon 733 or other positions associated with knockdown resistance in other arthropods has been identified. these da ...201423991892
relationship between the prevalence of ectoparasites and associated risk factors in free-range pigs in kenya.a cross-sectional study was undertaken to determine the prevalence of ectoparasites and possible risk factors in free-range pigs from 135 farms of busia district, kenya. three hundred and six pigs were examined for presence of external parasites using standard parasitological methods. data on management practices including housing and history of acaricide spraying were also collected. the ectoparasites found in the pigs were haematopinus suis (96.1%), sarcoptes scabiei (63.7%), and ticks (29.7%) ...201323984085
the use of radio-collars for monitoring wildlife diseases: a case study from iberian ibex affected by sarcoptes scabiei in sierra nevada, spain.wildlife radio tracking has gained popularity during the recent past. ecologists and conservationists use radio-collars for different purposes: animal movement monitoring, home range, productivity, population estimation, behaviour, habitat use, survival, and predator-prey interaction, among others. the aim of our present study is to highlight the application of radio-collars for wildlife diseases monitoring. the spread of wildlife diseases and the efficacy of management actions for controlling t ...201323965311
sarcoptes scabiei mites modulate gene expression in human skin equivalents.the ectoparasitic mite, sarcoptes scabiei that burrows in the epidermis of mammalian skin has a long co-evolution with its hosts. phenotypic studies show that the mites have the ability to modulate cytokine secretion and expression of cell adhesion molecules in cells of the skin and other cells of the innate and adaptive immune systems that may assist the mites to survive in the skin. the purpose of this study was to identify genes in keratinocytes and fibroblasts in human skin equivalents (hses ...201323940705
diagnosis, prevention, and treatment of scabies.scabies remains a public health problem, especially in developing countries, with a worldwide incidence of approximately 300 million cases each year. prolonged skin-to-skin contact is necessary to allow the transmission of the causative mite, sarcoptes scabiei. classic scabies presents with burrows, erythematous papules, and generalized pruritus. clinical variants include nodular scabies and crusted scabies, also called norwegian scabies. the diagnosis is based mainly on history and physical exa ...201323904181
characterisation and analysis of thioredoxin peroxidase as a potential antigen for the serodiagnosis of sarcoptic mange in rabbits by dot-elisa.scabies caused by sarcoptes scabiei is a widespread but a neglected tropical zoonosis. in this study, we characterised a s. scabiei thioredoxin peroxidase (sstpx) and evaluated a recombinant sstpx as a diagnostic antigen in rabbits.201323875925
in vivo imaging of sarcoptes scabiei infestation using optical coherence tomography.sarcoptes scabiei can be visualized with different imaging tools. optical coherence tomography (oct) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite.201323874291
prevalence and zoonotic aspects of small ruminant mange in the lateritic and waterlogged zones, southern benin.an epidemiological survey was undertaken from march to september 2010 to assess the prevalence and zoonotic aspects of scabies in small ruminants in two agro-ecological zones in southern benin. small ruminant (n = 444) smallholders and 1,807 of their animals (1,233 west african dwarf goats and 574 west african dwarf sheep) were included in the study. the animals underwent physical examination and, when scabies-like lesions were found, crusts and integument scrapings were collected for microscopi ...201323856728
identification and expression of macrophage migration inhibitory factor in sarcoptes scabiei.macrophage migration inhibitory factor (mif) is a pleiotropic proinflammatory cytokine produced by many mammalian tissues including skin. it is also found in many invertebrate parasites of mammals including ticks and may function to aid the parasite to evade the innate and adaptive immune responses in the host. in this study, the cdna for a mif gene was sequenced from sarcoptes scabiei, the scabies mite, using rt-pcr and race molecular techniques. the resulting nucleotide sequence had a length o ...201323831036
intense nocturnal itching should raise suspicion of scabies.scabies is caused by infestation with a parasitic mite sarcoptes scabiei var hominis. the itch and rash appear to be largely the result of a delayed (type iv) allergic reaction to the mite, its eggs and excreta. scabies is spread by a mite transferring to the skin surface of an unaffected person, usually by skin to skin contact with an infested person, but occasionally via contaminated bed linen, clothes or towels. in crusted scabies, mites are also dispersed within shed scales, enabling the con ...201323808128
efficacy of ivermectin and oxfendazole against taenia solium cysticercosis and other parasitoses in naturally infected pigs.smallholder semi-confined pig production is a fast growing practice in sub-saharan africa with an unfortunate outcome of high prevalence of taenia solium cysticercosis and other parasitoses. the widely used anthelmintic for control of endo and ecto-parasites in pigs in the area is ivermectin at a recommended dose of 0.3mg/kg. this study was conducted to evaluate the efficacy and safety in pigs after subcutaneous injection of ivermectin (ivm, 0.3mg/kg) and orally administration of oxfendazole (of ...201323806569
feline sarcoptic mange in taiwan: a case series of five cats.sarcoptes scabiei infestation is rare in cats.201323782002
antibody responses to sarcoptes scabiei apolipoprotein in a porcine model: relevance to immunodiagnosis of recent infection.no commercial immunodiagnostic tests for human scabies are currently available, and existing animal tests are not sufficiently sensitive. the recombinant sarcoptes scabiei apolipoprotein antigen sar s 14.3 is a promising immunodiagnostic, eliciting high levels of ige and igg in infected people. limited data are available regarding the temporal development of antibodies to sar s 14.3, an issue of relevance in terms of immunodiagnosis. we utilised a porcine model to prospectively compare specific ...201323762351
a review of pig pathology in tanzania.the approximately 1.58 million pigs in tanzania represent 3.7% of the national population of quadruped meat-producing animals. pigs are kept mainly by small producers who own 99.5% of the national stock in units that average 3.04 animals (range 2-48). government policy has had little practical application. african swine fever, foot-and-mouth disease and cysticercosis are important diseases. the first two are notifiable diseases under tanzania legislation; the last has widespread distribution and ...201323733144
variable performance of a human derived sarcoptes scabiei recombinant antigen elisa in swine mange diagnosis.the performance of an indirect elisa test based on sarcoptes scabiei var hominis recombinant antigen ssλ20δb3 (rec-elisa), to diagnose pig mange was investigated in 15 experimentally infected and non-infected pigs and 692 commercial pigs from 16 herds in southeast spain. these latter animals included 6-7 month old fatteners (13 herds), 11-12 month old replacement sows (1 herd) and ≥24 month old breeding sows (7 herds). all pigs were examined for mites in ear skin scrapings and the presence of s. ...201323683576
genetic epidemiology of sarcoptes scabiei in the iberian wolf in asturias, spain.during the last decades, attempts have been made to understand the molecular epidemiology of sarcoptes scabiei, and to detect and clarify the differences between isolates from different hosts and geographic regions. two main phenomena have been described: (i) host-taxon derived-sarcoptes mite infection in european wild animals (revealing the presence of three separate clusters, namely herbivore-, carnivore- and omnivore-derived sarcoptes populations in europe) and (ii) prey-to-predator sarcoptes ...201323664709
efficacy and safety of tinospora cordifolia lotion in sarcoptes scabiei var hominis-infected pediatric patients: a single blind, randomized controlled trial.to evaluate the clinical efficacy and safety of tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion.201323662023
the acaricidal efficacy of aqueous neem extract and ivermectin against sarcoptes scabiei var. cuniculi in experimentally infested rabbits.sarcoptes scabiei var. cuniculi is one of the most important veterinary ectoparasites in rabbits and results in considerable loss of weight, productivity, and wool quality. the acaricidal activity of aqueous leaf extract of neem (can) and ivermectin (ivr) were evaluated in vitro and in vivo against s. scabiei var. cuniculi. rabbits were classified into four groups (ten rabbits each). the first group (group 1) was designated as the negative control group. each rabbit of the other groups was exper ...201323572045
clinical efficacy of botanical extracts from eupatorium adenophorum against the sarcoptes scabiei (sarcoptidae: sarcoptes) in rabbits.the aims of present study were to evaluate the therapeutic efficacy of extracts from eupatorium adenophorum against sarcoptes scabiei. a 30-day experiment was performed using new zealand rabbits that were naturally infested with s. scabiei in the toes (n=30) or artificially infected in the external ear margin with s. scabiei (n=30). rabbits were randomly divided into five groups (6 animals per group, a-e groups for rabbits of naturally infested and f-j groups for artificially infected rabbits), ...201323518619
comparison of oral ivermectin versus crotamiton 10% cream in the treatment of scabies.scabies is a relatively contagious infection caused by a tiny mite (sarcoptes scabiei). products used to treat scabies are called scabicides because they kill scabies mites; some also kill mite eggs. the aim of this study was to compare the efficacy and safety of oral ivermectin versus crotamiton 10% cream for the treatment of scabies.201423431958
novel insights into an old disease: recent developments in scabies mite biology.scabies is a serious disease of both humans and other animals caused by infestation of the skin with the ectoparasitic mite sarcoptes scabiei. our current understanding of scabies mite biology and disease processes is far outweighed by the significant, worldwide impact of the disease. this review summarizes the recent data which furthers our knowledge of mite biology, host specificity and parasite host evasion mechanisms.201323385639
smallholder pig production: prevalence and risk factors of ectoparasites.a cross-sectional study was carried out in the mbeya region, tanzania, with the aim of describing the distribution and diversity of ectoparasites on pigs, within confinement and free-range production systems of smallholder farms. a total of 128 farms were surveyed, with 96 practising confinement and 32 practising free-range production systems. the prevalence of ectoparasites on pigs within confinement and free-range production systems was 24% and 84%, respectively. logistic regression analyses r ...201323357599
pathology of sarcoptic mange in red foxes (vulpes vulpes): macroscopic and histologic characterization of three disease stages.sarcoptic mange is a highly contagious skin disease that can have a devastating impact on affected wild mammal populations. there are notable variations in the clinical and pathologic picture of sarcoptic mange among species and among conspecifics. however, the origin of these variations is unclear. we propose a classification scheme for skin lesions associated with sarcoptes scabiei infestation to provide a basis for a subsequent risk factor analysis. we conducted a case-control study focused o ...201323307375
a survey on ectoparasite infestations in companion dogs of ahvaz district, south-west of iran.the objective was to determine the prevalence of ectoparasite infestations in referred companion dogs to veterinary hospital of shahid chamran university of ahvaz, from 2009 to 2010.201223293781
the treatment of bovine sarcoptic mange (sarcoptes scabiei var. bovis) using eprinomectin extended-release injection.the efficacy of eprinomectin in an extended-release injection (eri) formulation was evaluated in cattle harbouring induced infestations of sarcoptes scabiei var. bovis (sarcoptic mange) in three studies conducted in germany (two studies) and austria (one study). a total of 44 cattle were included in the studies, 12 in one study and 16 in each of the other two studies. approximately eight weeks following initial induced infestation, cattle in each study were formed into replicates of two animals ...201323273586
crusted scabies-associated immune reconstitution inflammatory syndrome.despite the widely accepted association between crusted scabies and human immunodeficiency virus (hiv)-infection, crusted scabies has not been included in the spectrum of infections associated with immune reconstitution inflammatory syndrome in hiv-infected patients initiating antiretroviral therapy.201223181485
on the aggregated nature of chronic sarcoptes scabiei infection in adult pigs.the prevalence and body distribution of sarcoptes scabiei and associated dermatitis was investigated in sows and boars from four herds with long standing mange. macroscopic hyperkeratotic dermatitis (crusted mange) was present in 1-6% of herd sows. mite estimated prevalence (95% ci) in ear scrapings was 11% (6-17%) including 100% (13/13) and 2% (3/134) in sows with and without crusted mange, respectively, and the later had very few mites compared to the former. s. scabiei body distribution and d ...201323131577
scratching the itch: new tools to advance understanding of scabies.scabies remains a significant public health problem worldwide. research into aspects of sarcoptes scabiei biology and host-parasite interactions has been impeded by an inability to maintain mites in vitro and by limited access to parasite material and infected subjects. the generation of comprehensive expressed sequence tag libraries has enabled the initial characterisation of molecules of interest to diagnostics, vaccines, and drug resistance. the recent development and utilisation of animal mo ...201323088958
vaccination with recombinant actin from scab mites and evaluation of its protective efficacy against psoroptes cuniculi infection.the mite psoroptes cuniculi is globally widespread and has a serious impact on commercial rabbit breeding. current treatment methods are based on chemotherapy. because of the disadvantages of these methods, alternative measures are required, and vaccination is one of the most promising strategies. here, we cloned and expressed the recombinant p. cuniculi actin gene (rpc-act). antiserum levels against rpc-act in rabbits were used to locate actin distribution in mite sections. challenge trials wer ...201323078134
a survey of ectoparasite infestation in dogs in tehran, iran.this survey was conducted to identify and estimate the frequencies of ectoparasites of dogs in tehran, iran. a total of 143 dogs attended at the small animal hospital of the veterinary school, the university of tehran, were examined for the presence of ectoparasites and dermatological lesions. ectoparasite specimens and blood samples were sent to parasitology and hematology laboratories, respectively. ticks were the most frequent ectoparasite (36.4%, 52/143), followed by fleas (29.4%, 42/143), m ...201223070452
participatory epidemiology to assess sarcoptic mange in serow of taiwan.we used participatory epidemiology (pe) in remote areas to understand the observed distribution and prevalence of infestation by sarcoptic mange mites (sarcoptes scabiei) on wild formosan serow (capricornis swinhoei) in taiwan. a semistructured interview protocol was used for 37 interviews during june-december 2008. serow with skin lesions consistent with sarcoptic mange were reported within a latitudinal range of approximately 24°00'n to 22°40'n on the central mountain range of taiwan. the obse ...201223060488
sarcoptic mange and cheetah conservation in masai mara (kenya): epidemiological study in a wildlife/livestock system.the sanitary control of threatened wild animals is of pivotal interest for their conservation. this task, however, is highly complex in wildlife/livestock systems. in this paper we report findings from a 2-year cross-sectional study of the epidemiology and attempted control of a sarcoptes mite infestation in the threatened cheetah population in masai mara (kenya), and discuss its interaction with sympatric wild (lion, wildebeest and thomson's gazelle) and domestic (dog, cattle and sheep) animals ...201223036718
parasite invasion following host reintroduction: a case study of yellowstone's wolves.wildlife reintroductions select or treat individuals for good health with the expectation that these individuals will fare better than infected animals. however, these individuals, new to their environment, may also be particularly susceptible to circulating infections and this may result in high morbidity and mortality, potentially jeopardizing the goals of recovery. here, using the reintroduction of the grey wolf (canis lupus) into yellowstone national park as a case study, we address the ques ...201222966139
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