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accelerated evolution of ces7, a gene encoding a novel major urinary protein in the cat family.cauxin is a novel urinary protein recently identified in the domestic cat that regulates the excretion of felinine, a pheromone precursor involved in sociochemical communication and territorial marking of domestic and wild felids. understanding the evolutionary history of cauxin may therefore illuminate molecular adaptations involved in the evolution of pheromone-based communication, recognition, and mate selection in wild animals. we sequenced the gene encoding cauxin, ces7, in 22 species repre ...201020966115
female reproductive cycles of wild female felids.many felid species are endangered because of destructive human activities. as a result, zoos are being tasked with sustaining genetically healthy populations in case of catastrophic extinctions. unfortunately, with the exception of a few species, most felids do not reproduce well in captivity. the ability to track reproductive activity via hormones is key to developing successful ex situ breeding programs. through the development of noninvasive fecal hormone monitoring techniques, a high degree ...201020888156
renal lesions of nondomestic felids.to comprehensively evaluate the occurrence of renal lesions in a variety of nondomestic felids, necropsy cases from 1978 to 2008 were reviewed from a municipal zoo and a large cat sanctuary for those in which the kidneys were examined histologically. seventy exotic felids were identified (25 tigers, 18 lions, 6 cougars, 5 leopards, 3 snow leopards, 3 clouded leopards, 3 canadian lynx, 2 ocelots, 2 bobcats, 2 cheetahs, 1 jaguar), and their histologic renal lesions were evaluated and compared. the ...201020876911
supermatrix and species tree methods resolve phylogenetic relationships within the big cats, panthera (carnivora: felidae).the pantherine lineage of cats diverged from the remainder of modern felidae less than 11 million years ago and consists of the five big cats of the genus panthera, the lion, tiger, jaguar, leopard, and snow leopard, as well as the closely related clouded leopard. a significant problem exists with respect to the precise phylogeny of these highly threatened great cats. despite multiple publications on the subject, no two molecular studies have reconstructed panthera with the same topology. these ...201020138224
why should a grazer browse? livestock impact on winter resource use by bharal pseudois nayaur.many mammalian herbivores show a temporal diet variation between graminoid-dominated and browse-dominated diets. we determined the causes of such a diet shift and its implications for conservation of a medium-sized ungulate-the bharal pseudois nayaur. past studies show that the bharal diet is dominated by graminoids (>80%) during summer, but the contribution of graminoids declines to about 50% in winter. we tested the predictions generated by two alternative hypotheses explaining the decline: lo ...201019784849
use of positive reinforcement conditioning to monitor pregnancy in an unanesthetized snow leopard (uncia uncia) via transabdominal ultrasound.closely monitoring snow leopard (uncia uncia) fetal developments via transabdominal ultrasound, with minimal stress to the animal, was the goal of this project. the staff at potter park zoo has used the principles of habituation, desensitization, and positive reinforcement to train a female snow leopard (u. uncia). ultrasound examinations were preformed on an unanesthetized feline at 63 and 84 days. the animal remained calm and compliant throughout both procedures. fetuses were observed and meas ...200819360606
neoplasia in felids at the knoxville zoological gardens, 1979-2003.a review of medical records and necropsy reports from 1979-2003 found 40 neoplasms in 26 zoo felids, including five lions (panthera leo, two males and three females), three leopards (panthera pardus, two males and one female), one jaguar (panthera onca, female), 11 tigers (panthera tigris, three males and eight females), two snow leopards (panthera uncia, one male and one female), two cougars (felis concolor, one male and one female), one bobcat (felis rufus, male), and one cheetah (acinonyx jub ...200819110704
a high-resolution cat radiation hybrid and integrated fish mapping resource for phylogenomic studies across felidae.we describe the construction of a high-resolution radiation hybrid (rh) map of the domestic cat genome, which includes 2662 markers, translating to an estimated average intermarker distance of 939 kilobases (kb). targeted marker selection utilized the recent feline 1.9x genome assembly, concentrating on regions of low marker density on feline autosomes and the x chromosome, in addition to regions flanking interspecies chromosomal breakpoints. average gap (breakpoint) size between cat-human order ...200918951970
molecular findings of disseminated histoplasmosis in two captive snow leopards (uncia uncia).this paper reports two cases of disseminated histoplasmosis in captive snow leopards (uncia uncia). histoplasmosis was diagnosed based on histopathology, immunohistochemistry, transmission electron microscopy, and molecular findings.200818817010
seroepidemiology of toxoplasma gondii in zoo animals in selected zoos in the midwestern united states.toxoplasma gondii infections in zoo animals are of interest because many captive animals die of clinical toxoplasmosis and because of the potential risk of exposure of children and elderly to t. gondii oocysts excreted by cats in the zoos. seroprevalence of t. gondii antibodies in wild zoo felids, highly susceptible zoo species, and feral cats from 8 zoos of the midwestern united states was determined by using the modified agglutination test (mat). a titer of 1:25 was considered indicative of t. ...200818605803
frustrated appetitive foraging behavior, stereotypic pacing, and fecal glucocorticoid levels in snow leopards (uncia uncia) in the zurich zoo.this study hypothesized that permanently frustrated, appetitive-foraging behavior caused the stereotypic pacing regularly observed in captive carnivores. using 2 adult female snow leopards (uncia uncia), solitarily housed in the zurich zoo, the study tested this hypothesis experimentally with a novel feeding method: electronically controlled, time-regulated feeding boxes. the expected result of employing this active foraging device as a successful coping strategy was reduced behavioral and physi ...200818444028
the complete mitochondrial genome structure of snow leopard panthera uncia.the complete mitochondrial genome (mtdna) of snow leopard panthera uncia was obtained by using the polymerase chain reaction (pcr) technique based on the pcr fragments of 30 primers we designed. the entire mtdna sequence was 16 773 base pairs (bp) in length, and the base composition was: a-5,357 bp (31.9%); c-4,444 bp (26.5%); g-2,428 bp (14.5%); t-4,544 bp (27.1%). the structural characteristics [0] of the p. uncia mitochondrial genome were highly similar to these of felis catus, acinonyx jubat ...200918431688
progressive encephalomyelopathy and cerebellar degeneration in a captive-bred snow leopard (uncia uncia). 200818424851
fatal sarcoptes scabiei infection of blue sheep (pseudois nayaur) in pakistan.sarcoptes scabiei was detected for the first time in skin scrapings, hair pluckings, and histologic sections from a blue sheep (pseudois nayaur) from the shimshali pamir in the karakorum range of the western himalaya in pakistan (36 degrees 28'n, 75 degrees 36'e). local reports suggest many hundred animals have been affected by a severe skin disease over a 10-yr period, but the shy nature of this species and the extreme climate that they inhabit meant only a single affected animal was available ...200717699091
systemic calicivirus epidemic in captive exotic felids.a 5-day-old, mother-raised, amur tiger cub (panthera tigris altaica) presented with tongue ulcerations. identical lesions appeared and progressed to sloughing of the tongue in the three littermates of this cub the following day. the lesions progressed in all cubs to include sloughing of the carpal, tarsal, metacarpal, and metatarsal foot pad epithelium. oral ulcerations were also noted in adult african lions (panthera leo) and amur tigers (panthera tigris altaica), but not in two adult snow leop ...200717679514
ancient papillomavirus-host co-speciation in felidae.estimating evolutionary rates for slowly evolving viruses such as papillomaviruses (pvs) is not possible using fossil calibrations directly or sequences sampled over a time-scale of decades. an ability to correlate their divergence with a host species, however, can provide a means to estimate evolutionary rates for these viruses accurately. to determine whether such an approach is feasible, we sequenced complete feline pv genomes, previously available only for the domestic cat (felis domesticus, ...200717430578
carnivore-caused livestock mortality in trans-himalaya.the loss of livestock to wild predators is an important livelihood concern among trans-himalayan pastoralists. because of the remoteness and inaccessibility of the region, few studies have been carried out to quantify livestock depredation by wild predators. in the present study, we assessed the intensity of livestock depredation by snow leopard uncia uncia, tibetan wolf canis lupus chanku, and eurasian lynx lynx l. isabellina in three villages, namely gya, rumtse, and sasoma, within the propose ...200717318699
molecular evidence for species-level distinctions in clouded leopards.among the 37 living species of felidae, the clouded leopard (neofelis nebulosa) is generally classified as a monotypic genus basal to the panthera lineage of great cats. this secretive, mid-sized (16-23 kg) carnivore, now severely endangered, is traditionally subdivided into four southeast asian subspecies (figure 1a). we used molecular genetic methods to re-evaluate subspecies partitions and to quantify patterns of population genetic variation among 109 clouded leopards of known geographic orig ...200617141620
highly conserved d-loop-like nuclear mitochondrial sequences (numts) in tiger (panthera tigris).using oligonucleotide primers designed to match hypervariable segments i (hvs-1) of panthera tigris mitochondrial dna (mtdna), we amplified two different pcr products (500 bp and 287 bp) in the tiger (panthera tigris), but got only one pcr product (287 bp) in the leopard (panthera pardus). sequence analyses indicated that the sequence of 287 bp was a d-loop-like nuclear mitochondrial sequence (numts), indicating a nuclear transfer that occurred approximately 4.8-17 million years ago in the tiger ...200617072079
phaeohyphomycosis in a snow leopard (uncia uncia) due to cladophialophora bantiana.phaeohyphomycosis caused by cladophialophora bantiana was diagnosed in a 5-month-old snow leopard with spastic paralysis of the hind legs and inability to defaecate or urinate. at post-mortem examination, a greenish soft mass resembling an abscess was found on one side of the epidural space at the fourth lumbar vertebral body. histological examination revealed a purulent meningitis with myelomalacia. dematiaceous fungal hyphae, present within the inflammatory infiltrate, were identified as c. ba ...200616542676
evolutionary analysis of a large mtdna translocation (numt) into the nuclear genome of the panthera genus species.translocation of cymtdna into the nuclear genome, also referred to as numt, has been reported in many species, including several closely related to the domestic cat (felis catus). we describe the recent transposition of 12,536 bp of the 17 kb mitochondrial genome into the nucleus of the common ancestor of the five panthera genus species: tiger, p. tigris; snow leopard, p. uncia; jaguar, p. onca; leopard, p. pardus; and lion, p. leo. this nuclear integration, representing 74% of the mitochondrial ...200616380222
effects of porcine zona pellucida immunocontraceptives in zoo felids.methods of contraception are necessary for management of zoo felids; however, the most commonly used contraceptive (melengestrol acetate implant) is associated with serious adverse reactions with long-term use. porcine zona pellucida (pzp) vaccines are promising as contraceptives, but their safety in zoo felids has not been tested. pzp vaccine was administered to 27 female felids representing 10 species, including african lion (panthera leo), asian leopard (p. pardus), jaguar (p. onca), tiger (p ...200415526881
blastomycosis in nondomestic felids.blastomycosis was diagnosed in six nondomestic felids from eastern tennessee, including two asian lions (panthera leo persicus), one african lion (panthera leo), one siberian tiger (panthera tigris), one cheetah (acinonyx jubatus), and one snow leopard (panthera uncia). clinical signs included lethargy, anorexia, weight loss, dyspnea, sneezing. ataxia, and paresis. variable nonspecific changes included leukocytosis, monocytosis, moderate left shift of neutrophils, moderate hypercalcemia, hyperpr ...200314582783
dirofilaria immitis infection of a snow leopard (uncia uncia) in a japanese zoo with mitochondrial dna analysis.three dog heartworms (dirofilaria immitis) were detected in the lumen of the right cardiac ventriculus and of the pulmonary artery of a captive female snow leopard (uncia uncia) that died of pancreatic carcinoma at a zoo in japan. neither clinical respiratory nor circulatory symptoms caused by the heartworm infection were observed. the filarial worms were identified as d. immitis from the morphologic characteristics of the esophagus, the presence of faint longitudinal ridges on the cuticular sur ...200312951432
identification of haemobartonella felis (mycoplasma haemofelis) in captive nondomestic cats.this study was undertaken to determine whether haemobartonella felis (mycoplasma haemofelis), the causative bacterial agent of feline infectious anemia, infects nondomestic cats. routine complete blood count and polymerase chain reaction (pcr) were performed to detect the gene for 16s ribosomal rna for the organism. sixty-four blood samples were collected from 54 nondomestic cats, including tigers (panthera tigris), cheetahs (acinonyx jubatus), lions (p. leo), mountain lions (felis concolor), sn ...200312885130
serum concentrations of lipids, vitamin d metabolites, retinol, retinyl esters, tocopherols and selected carotenoids in twelve captive wild felid species at four zoos.serum concentrations of several nutrients were measured in 12 captive wild felid species including caracal (felis caracal), cheetah (acinonyx jubatus), cougar (felis concolor), fishing cat (felis viverrinus), leopard (panthera pardus), lion (panthera leo), ocelot (felis pardalis), pallas cat (felis manul), sand cat (felis margarita), serval (felis serval), snow leopard (panthera uncia) and tiger (panthera tigris). diet information was collected for these animals from each participating zoo (broo ...200312514284
multiple ocular colobomas in the snow leopard (uncia uncia).two singleton female snow leopard cubs are reported with bilateral central upper lid colobomas. in addition, one cub had a coloboma of the fundus in one eye extending from the lower optic disc region. surgical treatment by wedge resection was successful in both cases. details of ocular colobomas in other snow leopards reported in the literature are described and it is suggested that the exact etiology of the condition in this species may be discovered by further study of similar colobomas in the ...200212236871
bilateral eyelid agenesis repair in a captive texas cougar.bilateral eyelid agenesis was presented with multiple ocular anomalies in a captive texas cougar (felis concolor). corneal exposure resulted in substantial keratoconjunctivitis and blepharospasm. bilateral inferopapillary fundic colobomas, persistent pupillary membranes, and an atypical iris coloboma od were present. surgical repair with a rotational pedicle flap resulted in functionally effective eyelids. trichiasis was later treated with cryotherapy. eyelid agenesis is reported infrequently in ...200212236863
positive effects of diet change on shedding of salmonella spp. in the feces of captive felids.a high prevalence of fecal salmonella shedding in a collection of healthy exotic felids precipitated a change to two new commercially available feline diets. one year after initiation of the new diets, 18 fecal samples from individual felines, their exhibits, and representative samples of the diets were cultured for salmonella spp. only one culture grew a salmonella sp. salmonella uganda was cultured from the feces of one snow leopard (felis uncia). feeding a diet with minimal to no salmonella c ...200212216800
[determination of clotting factor viii activity in mammals using the one-stage clotting and the chromogenic methods].two different laboratory assays exist for the determination of clotting factor viii activities in human plasma. one method is based on the one-stage clotting principle, the other one on the chromogenic principle. to evaluate the suitability for veterinary medicine human plasma and plasma of ten mammalian species (pig, cattle, dog, cat, zebra, llama, snow leopard, greater kudu, horse-like antelope, mink) were examined with each method. factor viii activities in human plasma determined using both ...200212174728
molecular cloning and phylogenetic analysis of canine beta-casein.a canine beta-casein cdna was isolated from mammary tissue by polymerase chain reaction (pcr) using degenerate primers. it encodes 250 amino acids protein containing the conserved sequence motif of beta-casein. it showed the highest homology with snow-leopard (uncia uncia (55-62% identity). it also showed 44-53% identity with human, 33-42%, identity with mouse, 29-37%, identity with rat, 43-53% identity with rabbit, 41-48% identity with pig, 44-51% identity with cattle and 44-50% identity with s ...200011092743
degenerative spinal disease in large felids.degenerative spinal disorders, including intervertebral disc disease and spondylosis, seldom occur in domestic cats. in contrast, a retrospective study of 13 lions (panthera leo), 16 tigers (panthera tigris), 4 leopards (panthera pardis), 1 snow leopard (panthera uncia), and 3 jaguars (panthera onca) from the knoxville zoo that died or were euthanatized from 1976 to 1996 indicated that degenerative spinal disease is an important problem in large nondomestic felids. the medical record, radiograph ...200010884118
feline papillomas and papillomaviruses.papillomaviruses (pvs) are highly species- and site-specific pathogens of stratified squamous epithelium. although pv infections in the various felidae are rarely reported, we identified productive infections in six cat species. pv-induced proliferative skin or mucous membrane lesions were confirmed by immunohistochemical screening for papillomavirus-specific capsid antigens. seven monoclonal antibodies, each of which reacts with an immunodominant antigenic determinant of the bovine papillomavir ...200010643975
deficiency of cytosolic arylamine n-acetylation in the domestic cat and wild felids caused by the presence of a single nat1-like gene.the purpose of this study was to determine the molecular basis for a relative deficiency in the cat of cytosolic arylamine n-acetyltransferase (nat), an enzyme family that is important in the metabolism of xenobiotics and that normally consists of at least two related enzymes, nat1 and nat2. n-acetyltransferase in feline liver showed high affinity (mean km = 2.1 microm) for p-aminobenzoic acid, an nat1 selective substrate in humans and rabbits, but showed a very poor affinity (mean km > 10 mm) f ...199810022754
gastric spiral bacteria in small felids.nine small cats, including one bobcat (felis rufus), one pallas cat (f. manul), one canada lynx (f. lynx canadensis), two fishing cats (f. viverrina), two margays (f. wiedii), and two sand cats (f. margarita), necropsied between june 1995 and march 1997 had large numbers of gastric spiral bacteria, whereas five large cats, including one african lion (panthera leo), two snow leopards (p. uncia), one siberian tiger (p. tigris altaica), and one jaguar (p. onca), necropsied during the same period ha ...19989732040
isolation of mycobacterium bovis from baboons, leopards and a sea-lion.this study reports on two series of cases of mycobacterium bovis infection in zoo animals. the first was in a captive population of baboons (papio hamadryas) and the second in a mixed group of wild mammals, including four leopards (panthera uncia and panthera pardus) and a sea-lion (otaria byrona). the isolation and identification of strains of m. bovis confirmed the presence of m. bovis infections in both zoos. the epidemiological study using genetic markers such as the is6110-based dna fingerp ...19989601152
diagnosis of tuberculosis in two snow leopards using polymerase chain reaction. 19989526869
seasonal effects on ovarian responsiveness to exogenous gonadotrophins and successful artificial insemination in the snow leopard (uncia uncia).ovaries of the seasonally-breeding snow leopard (uncia uncia) were examined to determine whether they were responsive to exogenous gonadotrophins throughout the year. the potential of laparoscopic artificial insemination (ai) also was assessed for producing offspring. during the non-breeding, pre-breeding, breeding and post-breeding seasons, females (n = 20) were treated with a standardized, dual-hormone regimen given intramuscularly (600 i.u. of equine chorionic gonadotrophin followed 80-84 h l ...19979261877
[liberation into the wild of wild felines--danger of the release of virus infections].there are several felidae amongst the numerous endangered species. means of aiding survival are the reintroduction to the wild of animals bred under the auspices of man and their relocation from densely populated to thinly populated areas. it is unlikely that the dangers of such reintroduction or relocation projects have been examined sufficiently in respect to the risks of virus infections confronting individuals kept in zoos or similar situations. this report presents three examples to illustr ...19969045289
snow leopard (panthera uncia) spermatozoa are sensitive to alkaline ph, but motility in vitro is not influenced by protein or energy supplements.to better understand the biology of snow leopard spermatozoa and to facilitate developing assisted reproduction, a series of studies was conducted to: 1) identify the component(s) of complex culture media responsible for the detrimental effect on sperm survival in vitro, 2) optimize medium for supporting sperm viability, and 3) evaluate sperm capacitation in vitro. constituents of complex media were added systematically to phosphate-buffered saline (pbs) to isolate the factor(s) influencing snow ...19968957700
amino acid sequences of mammalian kazal-type proteinase inhibitors from salivary glands.1. the amino acid sequences of bikazins (the double-headed kazal-type proteinase inhibitors from submandibular glands) isolated from the snow leopard (unica unica), the european mink (mustela lutreola), and the european pine marten (martes martes) were determined. 2. n-terminal domains of bikazins are characterized by a cysteine residue spacing that differs from that of c-terminal domains of bikazins and other kazal-type proteinase inhibitor domains. 3. n-terminal sequences of bikazins seem to b ...19938403842
serum concentrations of oestradiol and progesterone and frequency of sexual behaviour during the normal oestrous cycle in the snow leopard (panthera uncia).serum oestradiol and progesterone concentrations were measured at weekly intervals for six months, and correlated with daily behavioural observations in two adult female snow leopards (panthera uncia). three oestradiol peaks (> 21 pg ml-1; interval 3.6 weeks) were identified in a snow leopardess housed alone (two more were probably missed because of the weekly sampling schedule), and three oestradiol peaks were identified in a snow leopardess housed with a male as a breeding pair (interval 6 wee ...19938345484
function and culture requirements of snow leopard (panthera uncia) spermatozoa in vitro.electroejaculates from eight snow leopards were used to determine how the motility of spermatozoa was influenced by (i) type of media (ham's f10, pbs, human tubal fluid or rpmi-1640); (ii) holding temperature (23 degrees c versus 37 degrees c); (iii) washing of spermatozoa and (iv) a sperm metabolic enhancer, pentoxifylline. the duration of sperm motility was assessed by evaluating samples in each treatment every hour for 6 h and a sperm motility index (a value combining percentage sperm motilit ...19947966009
comparative aspects of steroid hormone metabolism and ovarian activity in felids, measured noninvasively in feces.noninvasive fecal assays were used to study steroid metabolism and ovarian activity in several felid species. using the domestic cat (felis catus) as model, the excretory products of injected [14c]estradiol (e2) and [14c]progesterone (p4) were determined. within 2 days, 97.0 +/- 0.6% and 96.7 +/- 0.5% of recovered e2 and p4 radioactivity, respectively, was found in feces. e2 was excreted as unconjugated estradiol and estrone (40%) and as a non-enzyme-hydrolyzable conjugate (60%). p4 was excreted ...19947819459
seasonal effects on seminal and endocrine traits in the captive snow leopard (panthera uncia).the annual reproductive cycle of the male snow leopard (panthera uncia) was characterized by evaluating seminal and endocrine traits monthly. testicular volume was greatest (p < 0.05) during the winter months when the quality of ejaculate was optimal. ejaculate volume, total sperm concentration ml-1, motile sperm concentration per ejaculate, sperm morphology and sperm motility index were lowest during the summer and autumn months compared with the winter and spring. peripheral lh, fsh and testos ...19947799318
comparative anatomy of the cardiac foramen ovale in cats (felidae), dogs (canidae), bears (ursidae) and hyaenas (hyaenidae).the structure of the foramen ovale from 16 species representing 4 carnivore families, the felidae, canidae, ursidae and hyaenidae, was studied using the scanning electron microscope. the felidae were represented by 9 domestic cat fetuses (felis catus), 2 snow leopard neonates (uncia uncia), an ocelot neonate (leopardus pardalis), 2 lion neonates (panthera leo), a panther neonate (panthera pardus) and 3 tigers (neofelis tigris), comprising 2 fetuses and a neonate. the canidae were represented by ...19957649822
demodicosis in a group of juvenile snow leopards. 19807451334
therapy of demodicosis in snow leopard challenged. 19817240012
tyzzer's disease in snow leopards.tyzzer's disease was diagnosed histologically in 2 litters of newborn snow leopard kittens. the gross and histological lesions were similar to those reported in domestic cats and other animals. no signs of illness was noted in either of the snow leopard dams.19846699226
the snow leopard. fusion in an elaborated delusional fantasy. 19846532219
use of modified live feline panleukopenia virus vaccine to immunize dogs against canine parvovirus.modified live feline panleukopenia virus (fplv) vaccine protected dogs against canine parvovirus (cpv) infection. however, unlike the long-lived (greater than or equal to 20-month) immunity engendered by cpv infection, the response of dogs to living fplv was variable. doses of fplv (snow leopard strain) in excess of 10(5.7) tcid50 were necessary for uniform immunization; smaller inocula resulted in decreased success rates. the duration of immunity, as measured by the persistence of hemagglutinat ...19836299142
multiple ocular coloboma (moc) in snow leopards (panthera uncia). clinical report, pedigree analysis, chromosome investigations and serum protein studies. 19854086323
total hip replacement in a snow leopard. 19854077659
mycotic pneumonia and meningoencephalitis due to aspergillus terreus in a neonatal snow leopard (panthera uncia). 19854032629
bilateral separation of the olecranon and proximal epiphysis from the ulnar diaphysis in a snow leopard cub. 19863505986
bilateral testicular seminoma in a snow leopard. 19863505984
periodontal status in snow leopards.periodontal examinations were performed on ten 1- to 22-year-old snow leopards (6 males and 4 females), using dentistry methods for determining the plaque and gingival indices. all tooth surfaces were probed, and alveolar bone attachment loss was determined. after subgingival plaque removal, plaque specimens were examined for differential bacterial morphotypes. the small number of leopards evaluated precluded definitive statistical analysis. however, the progression from gingival health to gingi ...19863505932
[multiple ocular coloboma (moc) with persistent pupillary membrane in the snow leopard (panthera uncia)].in a litter of three snow leopards, bilateral colobomata of the upper temporal eyelids, bilateral persistent pupillary membranes and a unilateral coloboma of the optic nerve entrance are described as "multiple ocular colobomata" (moc). the causal pathogenesis of each of the colobomata is discussed comparatively. the colobomata of the eyelids, essential feature of the moc syndrome in snow leopards, are most probably not of hereditary, but rather of intrauterine infectious viral origin.20123368914
veno-occlusive disease of the liver in captive cheetah.liver tissues from 126 captive cheetah were evaluated by light microscopy and histochemistry; eight animals were evaluated by electron microscopy. the main hepatic lesion, a vascular lesion resembling veno-occlusive disease (vod) of the liver and characterized by subendothelial fibrosis and proliferation of smooth muscle-like cells in the central veins, was seen in 60% of the sexually mature cheetah. although this hepatic vascular lesion was seen in cheetah as young as 1 year of age, the most se ...19883344570
seminoma and parathyroid adenoma in a snow leopard (panthera unica).a seminoma and parathyroid adenoma were diagnosed in an aged snow leopard. the ultrastructural appearance of the seminoma was similar to that described in the dog and in man. the lack of significant amounts of rough endoplasmic reticulum, golgi complexes and free ribosomes in the parathyroid adenoma suggested that it was non-functional. parathyroid adenoma has not been previously described in a large wild feline.19892760281
the larynx of roaring and non-roaring cats.dissections were made of the larynges of 14 species of the cat family, with representative specimens from all genera. it was found that the vocal folds of the larynx of genus panthera (with the exception of the snow leopard) form the basic structure of a sound generator well-designed to produce a high acoustical energy. combined with an efficient sound radiator (vocal tract) that can be adjusted in length, a panthera can use its vocal instrument literally to blow its own horn with a 'roar'. also ...19892606766
veno-occlusive disease in snow leopards (panthera uncia) from zoological parks.livers from 54 snow leopards, 4 days to 23 years old, that had died in 23 us zoos, were evaluated histopathologically to determine if the hepatic fibrosis, which has been noted to be prevalent in this species, was due to chronic active hepatitis from hepadnaviral infection, ito cell proliferation, or hemosiderosis. forty-two of 54 snow leopards had subintimal vascular fibrosis with partial or total occlusion of central and sublobular veins (veno-occlusive disease) of unknown origin. all 21 leopa ...19912017826
rescue and maturation in vitro of follicular oocytes collected from nondomestic felid species.the potential for rescuing immature oocytes from the ovaries of females of rare felid species which die or undergo medical ovariohysterectomy was evaluated. ovaries were recovered from 13 species representing 35 individuals in good-to-poor health. although the majority of females were 10 yr of age or older and in fair-to-poor health, a total of 846 oocytes were recovered of which 608 (71.9%) were classified as fair-to-excellent quality. one hundred of these oocytes were used for initial maturati ...19911805993
evidence for a fel d i-like molecule in the "big cats" (felidae species).in this study, we investigated the cross-reactivity pattern of ige and igg4 antibodies to the major feline allergen, fel d i. we studied the ige and igg4 response of 11 cat-allergic patients against fel d i-like structures in eight members of the felidae family: ocelot, puma, serval, siberian tiger, lion, jaguar, snow leopard, and caracal. hair from these "big cats" was collected, extracted, and used in a rast system and histamine-release test. by means of a rast-inhibition assay with affinity-p ...19901695231
isolation of p multocida f-3, 4 from a stillborn snow leopard. 19921542981
retrovirus infections in non-domestic felids: serological studies and attempts to isolate a lentivirus.an african lioness from the zoo of zurich had to be euthanized because of an inoperable tumor. the serum tested negative for feline leukemia virus (felv) p27 antigen by enzyme-linked immunosorbent assay (elisa) but was strongly positive for feline immunodeficiency virus (fiv) antibodies by elisa and western blot. when her only offspring and mate were tested for fiv, high antibody titers to fiv were also found in their serum. lymphocytes were prepared from these two lions on different occasions a ...19921337398
notoedric mange in a litter of snow leopards. 1978738955
an endoscopic approach to a snow leopard. 1978648831
virus-like particles in cystic mammary adenoma of a snow leopard.virus-like particles were observed in the giant cells of a mammary adenoma of a snow leopard kept in captivity. particles that measured 115 to 125 nm in diameter budded from the lamella of endoplasmic reticulum and were studded on their inner surfaces with dense granules (approximately 12 nm) that gave them their unique ultrastructural morphology. such particles were not observed extracellularly. type b or type c particles were not seen in the tumor tissue.1975171061
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