Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| borna disease virus (bdv) infection in cats a concise review based on current knowledge. | summary persistent viral infections of the central nervous system have been the subject of intense interest for decades. one of these viral agents has been identified as borna disease virus (bdv) of the family bornaviridae. there have been various reports that link bdv to staggering disease in cats, with symptoms that include ataxia and behavioural disorders, and the disease is often referred to as feline borna disease. serological and molecular detection of bdv has been reported at a higher pre ... | 2006 | 22077762 |
| avian bornaviruses escape recognition by the innate immune system. | like other pathogens that readily persist in animal hosts, members of the bornaviridae family have evolved effective mechanisms to evade the innate immune response. the prototype of this virus family, borna disease virus employs an unusual replication strategy that removes the triphosphates from the 5' termini of the viral rna genome. this strategy allows the virus to avoid activation of rig-i and other innate immune response receptors in infected cells. here we determined whether the newly disc ... | 2010 | 21994661 |
| Borna disease virus - fact and fantasy. | The occasion of Brian Mahy's retirement as editor of Virus Research provides an opportunity to reflect on the work that led one of the authors (Lipkin) to meet him shortly after the molecular discovery and characterization of Borna disease virus in the late 1980s, and work with authors Briese and Hornig to investigate mechanisms of pathogenesis and its potential role in human disease. This article reviews the history, molecular biology, epidemiology, and pathobiology of bornaviruses. | 2011 | 21968299 |
| A novel borna disease virus vector system that stably expresses foreign proteins from an intercistronic noncoding region. | Borna disease virus (BDV), a nonsegmented, negative-strand RNA virus, infects a wide variety of mammalian species and readily establishes a long-lasting, persistent infection in brain cells. Therefore, this virus could be a promising candidate as a novel RNA virus vector enabling stable gene expression in the central nervous system (CNS). Previous studies demonstrated that the 5' untranslated region of the genome is the only site for insertion and expression of a foreign gene. In this study, we ... | 2011 | 21937656 |
| intracerebral borna disease virus infection of bank voles leading to peripheral spread and reverse transcription of viral rna. | bornaviruses, which chronically infect many species, can cause severe neurological diseases in some animal species; their association with human neuropsychiatric disorders is, however, debatable. the epidemiology of borna disease virus (bdv), as for other members of the family bornaviridae, is largely unknown, although evidence exists for a reservoir in small mammals, for example bank voles (myodes glareolus). in addition to the current exogenous infections and despite the fact that bornaviruses ... | 2011 | 21935357 |
| development, optimization, and validation of a classical swine fever virus real-time reverse transcription polymerase chain reaction assay. | classical swine fever (csf) is an economically devastating disease of pigs. instrumental to the control of csf is a well-characterized assay that can deliver a rapid, accurate diagnosis prior to the onset of clinical signs. a real-time fluorogenic-probe hydrolysis (taqman) reverse transcription polymerase chain reaction (rt-pcr) for csf was developed by the united states department of agriculture (usda) at the plum island animal disease center (csf piadc assay) and evaluated for analytical and d ... | 2011 | 21908362 |
| detection and characterization of a distinct bornavirus lineage from healthy canada geese (branta canadensis). | avian bornaviruses (abv), identified in 2008, infect captive parrots and macaws worldwide. the natural reservoirs of these viruses are unknown. reverse transcription-pcr (rt-pcr) was used to screen oropharyngeal/cloacal swab and brain samples from wild canada geese (branta canadensis) for abv. approximately 2.9% of swab samples were positive for bornavirus sequences. fifty-two percent of brain samples from 2 urban flocks also tested positive, and brain isolates were cultured in duck embryo fibro ... | 2011 | 21900161 |
| dual infection of fetal and neonatal small ruminants with border disease virus and peste des petits ruminants virus (pprv): neuronal tropism of pprv as a novel finding. | dual infection of 26 fetal and neonatal small ruminants with border disease virus (bdv) and peste des petits ruminants virus (pprv) is reported. the animals included five aborted lamb fetuses, 19 neonatal lambs and two neonatal kids from flocks in regions of the black sea and the aegean region. bdv and pprv antigens were detected immunohistochemically in the brain, oral mucosa, intestine and lung of infected animals. reverse transcriptase-polymerase chain reaction was used to demonstrate pprv an ... | 2011 | 21899857 |
| molecular detection of pestiviruses in aborted foetuses from provinces in northern turkey. | all pestiviruses are important veterinary pathogens causing economic losses in cattle, sheep and pigs. besides the important economical losses, pestiviruses may compromise the normal immune response to other pathogens and increase the severity of other infections in sheep. in this study, aborted foetuses (cattle and sheep) in either coastal or inland black sea region of turkey were surveyed for the presence of rna from pestiviruses (bovine viral diarrhoea virus (bvdv), border disease virus (bdv) ... | 2011 | 21842445 |
| epidemiological survey of border disease virus among sheep from northern districts of japan. | the first epidemiological survey of border disease virus (bdv) was undertaken in small ruminants in japan. ovine sera, collected from the northern prefectures of hokkaido, aomori and iwate, were examined for the presence of antibodies against bdv using the neutralization peroxidase-linked antibody test. twenty-nine (17.6%) of one hundred and sixty-five samples were seropositive for bdv. results were specific, excluding cross-reactions with bovine viral diarrhea virus (bvdv). only one sample (0.6 ... | 2011 | 21778667 |
| experimental infection with chamois border disease virus causes long-lasting viraemia and disease in pyrenean chamois (rupicapra pyrenaica). | since 2001, severe outbreaks of disease associated with border disease virus (bdv) infection have been reported in the pyrenean chamois. the disease is characterized by variable degrees of cachexia, alopecia and neurological manifestations prior to death. the aim of this study was to investigate this disease under experimental conditions. to assess viral virulence, humoral immune response, dissemination and probable routes of transmission, seven chamois (five seronegative and two seropositive to ... | 2011 | 21775580 |
| new insights into the nuclear localization of retroviral gag proteins. | retroviruses assemble new virus particles that are released by budding from the plasma membranes of infected cells. gag proteins, encoded by retroviruses, orchestrate the assembly of virus particles in close collaboration with host cell machinery. the earliest steps in retrovirus assembly-those immediately following synthesis of gag on cytosolic ribosomes-are poorly understood. rous sarcoma virus (rsv) offers a unique model system for dissecting these early steps because the rsv gag protein unde ... | 2011 | 21738831 |
| a new permanent cell line derived from the bank vole (myodes glareolus) as cell culture model for zoonotic viruses. | abstract: | 2011 | 21729307 |
| investigation of schizophrenic patients from istanbul, turkey for the presence of west nile virus. | association of some neurotropic viruses like borna disease virus and herpes virus with schizophrenia is better explained. however, the role of west nile virus (wnv) infection in schizophrenia is not well documented. therefore, this study was performed to investigate possible association between schizophrenia and presence of antibodies and wnv rna in schizophrenic patients. for this, 200 blood samples from patients with schizophrenia and 200 from control groups were collected in istanbul, turkey. ... | 2011 | 21725713 |
| analysis of intracellular distribution of borna disease virus glycoprotein fused with fluorescent markers in living cells. | borna disease virus (bdv) is a non-segmented, negative-strand rna virus that is characterized by nuclear replication and persistent infection. a unique feature of bdv is that it releases only a small number of infectious particles from infected cells. although these characteristics might make it difficult to obtain a large amount of recombinant viruses in a reverse genetics system, the mechanism underlying the budding or assembly of bdv particle has remained largely unknown. in this study, as a ... | 2011 | 21566396 |
| borna disease virus antibody and rna from peripheral blood mononuclear cells of race horses and jockeys in korea. | during the last two decades, borna disease virus (bdv) has received much attention as a possible zoonotic agent, particularly as a cause of psychiatric disease. although several studies have shown that bdv is present in asia, bdv has not been detected in korea. this study was designed to further investigate the presence of bdv infection in korea. | 2011 | 21519538 |
| species characterization in the genus pestivirus according to palindromic nucleotide substitutions in the 5'-untranslated region. | the palindromic nucleotide substitutions (pns) at the three variable loci (v1, v2 and v3) in the 5'-untranslated region (utr) of the pestivirus genome have been considered for taxonomical segregation of the species, through the evaluation of 534 strains. on the basis of qualitative and quantitative secondary structure characteristics, species have been identified within the genus, determining genetic distances between species isolates, clarifying borderline and multirelated sequences, and charac ... | 2011 | 21514324 |
| borna disease virus infection of a horse in great britain. | 2011 | 21498268 | |
| [endogenous bornavirus elements in mammalian genome]. | approximately 8% of our genome is made up of endogenous retroviral elements. endogenous retrovirus is a fossil record of ancient retrovirus infection and, therefore, gives important insights into the evolutional relationship between retroviruses and their hosts. on the other hand, until recently, it has been believed that no endogenous non-retroviral viruses exist in animal genomes. we lately discovered endogenous elements homologous to the nucleoprotein of bornaviruses, a negative-strand rna vi ... | 2010 | 21488328 |
| genomic rnas of borna disease virus are elongated on internal template motifs after realignment of the 3' termini. | the terminal structures of the borna disease virus (bdv) genome (vrna) and antigenome (crna) differ from those of other negative strand rna viruses, as both molecules possess four nucleotides at the 3' terminus without an apparent template at the 5' end of the opposite strand. consequently, the v- and crna molecules are not perfect mirror images, a situation that is not compatible with conventional strategies to maintain genetic information. we show here that recombinant viruses recovered from c ... | 2011 | 21482759 |
| expression of interferon gamma in the brain of cats with natural borna disease virus infection. | borna disease virus (bdv) is a neurotropic, negative-stranded rna virus, which causes a non-suppurative meningoencephalomyelitis in a wide range of animals. in cats, bdv infection leads to staggering disease. in spite of a vigorous immune response the virus persists in the central nervous system (cns) in both experimentally and naturally infected animals. since the cns is vulnerable to cytotoxic effects mediated via nk-cells and cytotoxic t-cells, other non-cytolytic mechanisms such as the inter ... | 2011 | 21419498 |
| capture of infectious borna disease virus using anionic polymer-coated magnetic beads. | borna disease virus (bdv) is a noncytolytic, neurotrophic virus that infects a range of vertebrates, including all warm-blooded animals and possibly humans. although bdv infections are thought to cause neurological disorders, evidence of the presence of the virus in tissues or blood of psychiatric patients is limited, possibly due to the low sensitivity of detection methods. here, a simple method for capturing bdv has been developed using magnetic beads coated with an anionic polymer, poly(methy ... | 2011 | 21406215 |
| isolation and identification of a bovine viral diarrhea virus from sika deer in china. | bovine viral diarrhea virus (bvdv) infections continue to cause significantly losses in the deer population. better isolation and identification of bvdv from sika deer may contribute significantly to the development of prophylactic therapeutic, and diagnostic reagents as well as help in prevention and control of bvdv. however, isolation and identification of bvdv from sika deer is seldom reported in literature. in this study, we collected some samples according to clinical sign of bvdv to isolat ... | 2011 | 21352530 |
| viral interference with neuronal integrity: what can we learn from the borna disease virus? | the neurotropic borna disease virus (bdv) is unusual in that it can persistently infect neurons of the central nervous system (cns) without causing general cell death, reflecting its favourable adaptation to the brain. the activity-dependent enhancement of neuronal network activity is however disturbed after bdv infection, possibly by its effect on the protein kinase c signalling pathway. the best model for studying bdv, which has a non-cytolytic replication strategy in primary neurons, is the r ... | 2011 | 21331522 |
| upregulation of insulin-like growth factor binding protein 3 in astrocytes of transgenic mice that express borna disease virus phosphoprotein. | in a previous study, we demonstrated that transgenic mice that express borna disease virus (bdv) phosphoprotein (p) in astrocytes show striking neurobehavioral abnormalities resembling those in bdv-infected animals. to understand the molecular disturbances induced by the expression of p in astrocytes, we performed microarray analysis with cultured astroglial cells transiently expressing p. we showed that expression of insulin-like growth factor binding protein 3 mrna increases not only in p-expr ... | 2011 | 21325425 |
| [construction of phylogenetic tree and sequence analysis on bdv p24 gene in both livestock and host in ningxia.] | objective: to gain detailed insights into the borna disease virus infection and its genetic characteristics and phylogeny in ningxia, china. methods: bdv p24 segment were detected by fluorescence quantitative nested rt-pcr from peripheral blood mononuclear cells of 119 patients with viral encephalitis, 205 cattle, 978 sheep, 46 patients with cerebrovascular diseases and 13 patients with multiple sclerosis. data from phylogenetic analysis on bdv p24 positive samples together with those from the p ... | 2010 | 21215083 |
| comparison of hematological and biochemical parameters in sheep naturally and persistently infected with a border disease virus. | in this study, we investigated the changes occurring in the activities of determining the biochemical and hematological parameters in persistently infected sheep with border disease virus (bdv) and control sheep. while cholesterol, aspartate aminotransferase, lactate dehydrogenase, high-density lipoprotein, and glucose parameters were found to be statistically different between control and bdv positive groups (p<0.01), total protein, alkaline phosphotase, creatine kinase, amylase, glucose, and h ... | 2010 | 21104124 |
| retrospective study of pestivirus infection in pyrenean chamois (rupicapra pyrenaica) and other ungulates in the pyrenees (ne spain). | in 2001 a new pestivirus (family flaviviridae) was associated with an outbreak of a previously unreported disease in pyrenean chamois (rupicapra pyrenaica) in the pyrenees (ne spain). molecular characterization assigned this virus to the border disease virus (bdv) cluster, bdv-4 genotype. a retrospective study was performed in archived sera and spleen of 74 pyrenean chamois and in archived sera of 28 mouflon (ovis ammon), 56 red deer (cervus elaphus), 43 roe deer (capreolus capreolus) and 29 fal ... | 2010 | 20961710 |
| a synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats. | chronic cns infection by several families of viruses can produce deficits in prefrontal cortex (pfc) and striatal function. cannabinoid drugs have been long known for their anti-inflammatory properties and their ability to modulate adult neuro and gliogenesis. therefore, we explored the effects of systemic administration of the cannabinoid agonist win55,212-2(win) on prefrontal cortex (pfc) and striatal cytogenesis in a viral model of cns injury and inflammation based on borna disease (bd) virus ... | 2010 | 20832403 |
| borna disease virus (bdv) circulating immunocomplex positivity in addicted patients in the czech republic: a prospective cohort analysis. | borna disease virus (bdv) is an rna virus belonging to the family bornaviridae. borna disease virus is a neurotropic virus that causes changes in mood, behaviour and cognition. bdv causes persistent infection of the central nervous system. immune changes lead to activation of infection. alcohol and drug dependence are associated with immune impairment. | 2010 | 20825673 |
| border disease virus shedding and detection in naturally infected pyrenean chamois (rupicapra pyrenaica). | pyrenean chamois (rupicapra pyrenaica) populations of the central and eastern pyrenees have been affected by severe outbreaks associated with border disease virus (bdv) since 2001. eight pyrenean chamois (7 males and 1 female) from 1 to 8 years of age with clinical signs consistent with bdv infection were studied. at necropsy, whole blood, tissue samples (skin, brain, prescapular lymph node, thyroid gland, lung, liver, spleen, kidney, small intestine, bone marrow, and testicle), urine, and nasal ... | 2010 | 20807933 |
| epidemiology of pestivirus infection in wild ungulates of the french south alps. | inter-species transmission is often incriminated in the epidemiology of pestivirus diseases. the purpose of this study was to investigate the prevalence of pestivirus in some mountain wild ungulates and to determine their role in pestivirus transmission, as mountain pastures are a place where cohabitations between wild and domestic ungulates are particularly high. between 2003 and 2007, a longitudinal epidemiological study was carried out on hunted ungulates in the french hautes-alpes department ... | 2011 | 20709472 |
| genetic and antigenic typing of border disease virus (bdv) isolates from italy reveals the existence of a novel bdv group. | border disease virus belongs to the pestivirus genus, within the family flaviviridae. genetic analysis of pestiviruses isolated from sheep in continental europe have led to the proposal that bdv isolates are segregated into at least seven clusters. in 2005 the molecular analysis of an italian caprine bdv strain provided evidence for the presence of an atypical pestivirus, which may represent the first member of a putative novel pestivirus sub-group. to further build on this study, ovine pestivir ... | 2011 | 20656426 |
| haematology and serum chemistry of pyrenean chamois (rupicapra pyrenaica) naturally infected with a border disease virus. | in 2005 and 2006 an outbreak of disease associated with border disease virus (bdv) infection caused high mortality in the pyrenean chamois (rupicapra pyrenaica) in the catalan pyrenees (ne spain). the aim of this study was to determine values for different haematological and serum biochemical analytes in 32 free-ranging pyrenean chamois affected by the disease and to compare them with those obtained from healthy chamois. in the affected chamois red blood cell counts, haemoglobin concentrations, ... | 2011 | 20656309 |
| complete genomic sequence of a border disease virus isolated from pyrenean chamois. | this report describes the full-length genome sequence of the pestivirus strain h2121 which was recently isolated from pyrenean chamois and typed as border disease virus (bdv) genotype 4. comparison with full-length genomic sequences of the approved pestivirus species bovine viral diarrhea virus-1 (bvdv-1), bvdv-2, bdv, and classical swine fever virus, the tentative species represented by strain giraffe-1, as well as the atypical pestivirus strain th/04_khonkaen confirmed that the chamois pestivi ... | 2010 | 20638945 |
| modulation of mir-122 on persistently borna disease virus infected human oligodendroglial cells. | using rnahybrid software we found the predicted binding of complementary sequences between mir-122 and viral mrnas, may be important for the antiviral effect of mir-122 on borna disease virus (bdv). a moderate expression of mir-122 was identified in human oligodendroglial cells (ol), but with a much lower level of mir-122 in bdv persistent infection (ol/bdv) and cells transfected with bdv gene expression vectors. over-expression of mir-122 and specific blocking experiments demonstrated that mir- ... | 2010 | 20561966 |
| border disease virus seroprevalence correlates to antibodies in bulk-tank milk and reproductive performance of dairy sheep flocks. | there is a great need to establish effective tools to control border disease virus (bdv) in european dairy sheep flocks. hence, our main aim was to investigate the accuracy of analyzing anti-bdv antibodies in bulk-tank milk (btm) in detecting the real bdv seroprevalence in dairy sheep flocks. furthermore, the relevance of bdv to reproductive performance of dairy sheep flocks prompted us to search for the association between bdv seroprevalence and reproductive parameters. for these purposes, 34 f ... | 2010 | 20494152 |
| neuropathologic study of border disease virus in naturally infected fetal and neonatal small ruminants and its association with apoptosis. | the present study describes the pathologic changes and cellular apoptosis in the central nervous system (cns) of fetal and neonatal small ruminants infected with border disease virus (bdv), as demonstrated by immunohistochemistry and in situ hybridization. abortions of ewes and goats were observed, as were births of lambs and kids with poor survival rates and nervous signs. lesions included cerebellar hypoplasia, porencephaly, hydranencephaly, and nonsuppurative meningoencephalomyelitis with hyp ... | 2011 | 20460448 |
| experimental infection of pigs with border disease virus isolated from pyrenean chamois (rupicapra pyrenaica). | between 2001 and 2007, several outbreaks of disease associated with border disease virus (bdv) infection were reported in the central pyrenees (northeast spain) and were associated with a major reduction in chamois (rupicapra pyrenaica) populations. at the same time, wild boars (sus scrofa) from the same area were found to be seropositive to this pestivirus, without showing clinical signs. the present study examines the susceptibility of domestic swine and the course of the infection with a bdv ... | 2010 | 20453208 |
| characteristics of the 5' untranslated region of wisent (bison bonasus) and reindeer (rangifer tarandus) pestivirus isolates. | the 5'-untranslated region (5'-utr) of the pestivirus strains isolated from wisent and reindeer suffering from severe diarrhoea in the duisburg zoo in germany were amplified by reverse transcription-polymerase chain reaction and sequenced for comparison with those of other pestiviruses from cattle, sheep, goats and swine. phylogenetic trees constructed from the primary nucleotide sequences of these strains demonstrated that the 5'-utr of both the wisent and reindeer isolates were identical and s ... | 2006 | 20429058 |
| anti-borna disease virus antibody responses in psychiatric patients: long-term follow up. | data suggesting a pathogenetic role for borna disease virus (bdv) in neuropsychiatric diseases are still inconclusive and it is unknown whether humans become persistently infected or clear the virus infection. the aim of the present study was therefore to investigate long-term bdv-specific antibody responses in psychiatric patients in order to gain new insights into human bdv infection and its pathogenicity. | 2010 | 20408992 |
| protein kinase c-dependent phosphorylation of borna disease virus p protein is required for efficient viral spread. | mutational analysis of the phosphate acceptor sites of the borna disease virus (bdv) phosphoprotein (p) has suggested a role of phosphorylation for viral spread. however, the studied mutant viruses also had two amino acid exchanges in the x protein, because the reading frames of p and x overlap. to determine the relative contribution of p and x to viral attenuation, we studied a p variant with serine-to-leucine substitutions (p(s26l,s28l)) in which the wild-type x sequence was conserved. viral s ... | 2010 | 20333534 |
| prevalence and antigenic differences observed between bovine viral diarrhea virus subgenotypes isolated from cattle in australia and feedlots in the southwestern united states. | bovine viral diarrhea virus (bvdv) is divided into 2 different species within the pestivirus genus, bvdv type 1 (bvdv-1) and bvdv type 2 (bvdv-2). further phylogenetic analysis has revealed subgenotype groupings within the 2 types. thus far, 12 bvdv-1 subgenotypes (a-l) and 2 bvdv-2 subgenotypes (a and b) have been identified. the purpose of the current study was to determine the prevalence of bvdv subgenotypes in the united states and australia and to determine if there are detectable antigenic ... | 2010 | 20224075 |
| visualizing viral dissemination in the mouse nervous system, using a green fluorescent protein-expressing borna disease virus vector. | borna disease virus (bdv) frequently persists in the brain of infected animals. to analyze viral dissemination in the mouse nervous system, we generated a mouse-adapted virus that expresses green fluorescent protein (gfp). this viral vector supported gfp expression for up to 150 days and possessed an extraordinary staining capacity, visualizing complete dendritic arbors as well as individual axonal fibers of infected neurons. gfp-positive cells were first detected in cortical areas from where th ... | 2010 | 20219925 |
| avian bornavirus associated with fatal disease in psittacine birds. | thanks to new technologies which enable rapid and unbiased screening for viral nucleic acids in clinical specimens, an impressive number of previously unknown viruses have recently been discovered. two research groups independently identified a novel negative-strand rna virus, now designated avian bornavirus (abv), in parrots with proventricular dilatation disease (pdd), a severe lymphoplasmacytic ganglioneuritis of the gastrointestinal tract of psittacine birds that is frequently accompanied by ... | 2010 | 20219910 |
| animal models of cns viral disease: examples from borna disease virus models. | borna disease (bd), caused by the neurotropic rna virus, borna disease virus, is an affliction ranging from asymptomatic to fatal meningoencephalitis across naturally and experimentally infected warmblooded (mammalian and bird) species. more than 100 years after the first clinical descriptions of borna disease in horses and studies beginning in the 1980's linking borna disease virus to human neuropsychiatric diseases, experimentally infected rodents have been used as models for examining behavio ... | 2010 | 20204069 |
| [epidemiological investigation on natural infection of different canine breeds with borna disease virus in ili, china]. | to investigate the epidemiological pattern of borna disease virus (bdv) among different canine breeds in ili, china, and to analyze its potential phylogeny. | 2009 | 20193374 |
| [research on the association between borna disease virus infection and the viral encephalitis.]. | to investigate the infection of borna disease virus (bdv) in unidentified viral encephalitis patients in ningxia in order to explore if the nucleotide sequence and amino acid sequence in bdv p24 were homophylic with the overseas standard strain. we also intended to investigate the correlation between bdv infection and the unidentified viral encephalitis patients from ningxia to lay an experimental basis for etiological diagnosis, prevention and treatment on certain human neuropsychiatric disorde ... | 2009 | 20193316 |
| borna disease in an adult alpaca stallion (lama pacos). | borna disease (bd) was diagnosed in a 2-year-old male alpaca with a history of chronic suppressed sexual desire and acute stretching convulsions. microscopical examination of the central nervous system revealed non-purulent meningoencephalitis with mononuclear perivascular cuffing. the diagnosis was confirmed by immunohistochemistry, in-situ hybridization, polymerase chain reaction (pcr) and sequencing of pcr products and alignment with known borna disease virus sequences. serological screening ... | 2010 | 20153871 |
| failure to detect borna disease virus antibody and rna from peripheral blood mononuclear cells of psychiatric patients. | borna disease virus (bdv) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. over the past two decades, it has been suggested that bdv might be associated with human psychiatric diseases. we aimed to investigate whether bdv is associated with psychiatric patients in korea. | 2009 | 20140130 |
| distribution of borna disease virus antigen and rna in tissues of naturally infected bicolored white-toothed shrews, crocidura leucodon, supporting their role as reservoir host species. | borna disease is a severe viral-induced disorder of the central nervous system of horses, sheep, and a few other animal species, occurring in certain areas of central europe. pathogenesis and epidemiology of natural borna disease virus (bdv) infections are still not fully understood; several unique epidemiologic features, however, point toward the existence of bdv reservoir populations other than the final hosts. in this study, 69 mice and 12 shrews were trapped and examined. the virus distribut ... | 2010 | 20133953 |
| identification of host factors involved in borna disease virus cell entry through a small interfering rna functional genetic screen. | borna disease virus (bdv), the prototypic member of the bornaviridae family, within the order mononegavirales, is highly neurotropic and constitutes an important model system for the study of viral persistence in the central nervous system (cns) and associated disorders. the virus surface glycoprotein (g) has been shown to direct bdv cell entry via receptor-mediated endocytosis, but the mechanisms governing cell tropism and propagation of bdv within the cns are unknown. we developed a small inte ... | 2010 | 20071576 |
| endogenous non-retroviral rna virus elements in mammalian genomes. | retroviruses are the only group of viruses known to have left a fossil record, in the form of endogenous proviruses, and approximately 8% of the human genome is made up of these elements. although many other viruses, including non-retroviral rna viruses, are known to generate dna forms of their own genomes during replication, none has been found as dna in the germline of animals. bornaviruses, a genus of non-segmented, negative-sense rna virus, are unique among rna viruses in that they establish ... | 2010 | 20054395 |
| virology: bornavirus enters the genome. | 2010 | 20054386 | |
| pestivirus infection in sheep and goats in west austria. | blood samples from 3112 sheep (185 flocks) and 1196 goats (163 flocks) from the western region of austria were tested for pestivirus-specific rna. in this area, communal alpine pasturing of sheep, cattle and goats is an important part of farming. the prevalence of sheep persistently-infected (pi) with pestivirus was 0.32% (10 animals) and the pi animals originated from five flocks (2.7% of those investigated). in goats, only one pi animal (0.08%) was detected. sequence analysis of the 5'-end unt ... | 2010 | 20042353 |
| the diagnosis of proventricular dilatation disease: use of a western blot assay to detect antibodies against avian borna virus. | avian borna virus (abv) has recently been shown to be the causal agent of proventricular dilatation disease (pdd) a lethal neurologic disease of captive psittacines and other birds. an immunoblot assay was used to detect the presence of antibodies against avian borna virus in the serum of affected birds. a lysate from abv-infected duck embryo fibroblasts served as a source of antigen. the assay was used to test for the presence of antibodies to abv in 117 birds. thirty of these birds had biopsy ... | 2010 | 20036080 |
| rna induced polymerization of the borna disease virus nucleoprotein. | the borna disease virus (bdv) nucleoprotein (n) monomer resembles the nucleoprotein structures from rabies virus (rabv) and vesicular stomatitis virus (vsv). we show that bdv n assembles into ring- and string-like structures in the presence of 5' genomic bdv rna. rna induced polymerization is partly rna-specific since polymerization is inefficient in the presence of 3' genomic bdv rna or e. coli rna. mutagenesis of basic residues located in the cleft made up by the n- and c-terminal domains of n ... | 2010 | 19945724 |
| autogenous translational regulation of the borna disease virus negative control factor x from polycistronic mrna using host rna helicases. | borna disease virus (bdv) is a nonsegmented, negative-strand rna virus that employs several unique strategies for gene expression. the shortest transcript of bdv, x/p mrna, encodes at least three open reading frames (orfs): upstream orf (uorf), x, and p in the 5' to 3' direction. the x is a negative regulator of viral polymerase activity, while the p phosphoprotein is a necessary cofactor of the polymerase complex, suggesting that the translation of x is controlled rigorously, depending on viral ... | 2009 | 19893625 |
| detection and quantification of pestivirus in experimentally infected pregnant ewes and their progeny. | border disease virus (bdv) causes important reproductive losses, and eradication strategies focus on the identification and removal of persistently infected animals arising after in uterine infection. bdv infection dynamics were studied in 13 ewes experimentally infected with bdv-4 genotype at 3 phases of pregnancy [days 108 (group a), 76 (group b) and 55 (group c)] by quantification of viral rna in blood collected on days -1 to parturition using quantitative real-time rt-pcr (qrt-pcr). viral rn ... | 2009 | 19891772 |
| bovine viral diarrhea virus infections in heterologous species. | infections with bovine viral diarrhea virus (bvdv) are not limited to cattle, but may be detected in various species in the mammalian order artiodactyla. despite epidemiological evidence of bvdv infections in species other than cattle, current knowledge regarding the impact of bvdv on heterologous species is incomplete. in heterologous hosts, bvdv infections with clinical signs analogous to those in cattle have been described and include disease of multiple organ systems, most notably the reprod ... | 2010 | 19883524 |
| viral obesity: fact or fiction? | the aetiology of obesity is multifactorial. an understanding of the contributions of various causal factors is essential for the proper management of obesity. although it is primarily thought of as a condition brought on by lifestyle choices, recent evidence shows there is a link between obesity and viral infections. numerous animal models have documented an increased body weight and a number of physiologic changes, including increased insulin sensitivity, increased glucose uptake and decreased ... | 2010 | 19874530 |
| the glutamate-based genetic immune hypothesis in obsessive-compulsive disorder. an integrative approach from genes to symptoms. | recent advances in multiple areas of research have contributed to the identification of several pathophysiological factors underlying obsessive-compulsive disorder (ocd). in particular, the glutamate transporter gene slc1a1 has been associated with the diagnosis of ocd. immunological and infectious studies have reported alterations of the immune system and the presence of immune complexes directed against the borna disease virus in ocd patients. in addition, neuroimaging of ocd patients has demo ... | 2010 | 19861150 |
| borna disease virus circulating immunocomplex positivity and psychopathology in psychiatric patients in the czech republic. | borna disease virus (bdv) is an rna virus belonging to the family bornaviridae. bdv is a neurotropic virus that causes changes in mood, behaviour and cognition. patients with psychiatric disorders have a higher incidence of bdv positivity than healthy individuals. | 2009 | 19855370 |
| viral infection leading to brain dysfunction: more prevalent than appreciated? | virus infections of the brain can lead to transient or permanent neurologic or psychiatric dysfunction. some of the complexities in establishing the causal role of viruses in brain disease are explored here. | 2009 | 19840542 |
| borna disease virus infection alters synaptic input of neurons in rat dentate gyrus. | granule cells are major targets of entorhinal afferents terminating in a laminar fashion in the outer molecular layer of the dentate gyrus. since borna disease virus (bdv) infection of newborn rats causes a progressive loss of granule cells in the dentate gyrus, entorhinal fibres become disjoined from their main targets. we have investigated the extent to which entorhinal axons react to this loss of granule cells. unexpectedly, anterograde dii tracing has shown a prominent layered termination of ... | 2009 | 19806365 |
| avian bornaviruses in psittacine birds from europe and australia with proventricular dilatation disease. | to determine whether avian bornaviruses (abvs) were a factor in proventricular dilatation disease (pdd), we used immunohistochemistry, reverse transcription-pcr, and nucleotide sequence analysis to examine paraffin wax-embedded or frozen tissue samples of 31 psittacine birds with this disease. pdd is a fatal disease of psittacine birds associated with nonsuppurative encephalitis and ganglioneuritis of the upper intestinal tract. tissue samples had been collected from 1999 through 2008 in austria ... | 2009 | 19788814 |
| antigenic and genetic characterisation of border disease viruses isolated from uk cattle. | available empirical data on the natural occurrence of ruminant pestiviruses has shown that in cattle, bovine viral diarrhoea virus (bvdv) is nearly exclusively found, whereas both border disease virus (bdv) and bvdv can be isolated from sheep. during routine genetic typing of pestivirus rna from uk cattle diagnosed as bvdv positive between 2006 and 2008, five samples that were classified as bdv positive yielded positive virus isolates in cell cultures. the samples originated from animals that ha ... | 2010 | 19781869 |
| molecular chaperone bip interacts with borna disease virus glycoprotein at the cell surface. | borna disease virus (bdv) is characterized by highly neurotropic infection. bdv enters its target cells using virus surface glycoprotein (g), but the cellular molecules mediating this process remain to be elucidated. we demonstrate here that the n-terminal product of g, gp1, interacts with the 78-kda chaperone protein bip. bip was found at the surface of bdv-permissive cells, and anti-bip antibody reduced bdv infection as well as gp1 binding to the cell surface. we also reveal that bip localizes ... | 2009 | 19776128 |
| proteomics computational analyses suggest that the bornavirus glycoprotein is a class iii viral fusion protein (gamma penetrene). | borna disease virus (bdv) is the type member of the bornaviridae, a family of viruses that induce often fatal neurological diseases in horses, sheep and other animals, and have been proposed to have roles in certain psychiatric diseases of humans. the bdv glycoprotein (g) is an extensively glycosylated protein that migrates with an apparent molecular mass of 84,000 to 94,000 kilodaltons (kda). bdv g is post-translationally cleaved by the cellular subtilisin-like protease furin into two subunits, ... | 2009 | 19765297 |
| borna disease virus in raccoons (procyon lotor) in japan. | we have examined the seroprevalence of bdv in wild raccoons (procyon lotor) in hokkaido, japan. serum samples from raccoons were examined using elisa and western blot assays to detect the presence of serum antibodies that react specifically to bdv antigens. among 549 investigated individuals, eleven (2.0%) showed a positive reaction to bdv antigens. brain tissue samples from five individuals were subjected to rt-pcr, which detected bdv sequences in three of them. sequence analysis revealed a hig ... | 2009 | 19721351 |
| identification of rna instability elements in borna disease virus. | genome organization and gene expression of borna disease virus (bdv) are remarkable for the overlap of open reading frames, transcription units and transcription signals, readthrough of transcription termination signals, differential use of translation initiation codons, and exploitation of the cellular splicing machinery. here we report an additional control of gene expression at the level of mrna stability. levels of bdv proteins in infected cells do not correspond to the transcriptional gradi ... | 2009 | 19720240 |
| investigations of cerebrospinal fluid in borna disease virus seropositive psychiatric patients. | borna disease virus (bdv) appears to cause meningoencephalitis and schizophreniform psychosis in sporadic cases according to earlier cerebrospinal fluid (csf) inoculation experiments (rott et al, 1991). however, csf parameters in bdv seropositive psychiatric patients proved nearly all normal; only the most sensitive csf/serum index i-bdv for intrathecally produced bdv specific igg was pathologic in 10.5-29.0% (according to different methodological limits) of patients. an increase in sensitivity ... | 1995 | 19698348 |
| cell entry of borna disease virus follows a clathrin-mediated endocytosis pathway that requires rab5 and microtubules. | borna disease virus (bdv), the prototypic member of the bornaviridae family within the order mononegavirales, exhibits high neurotropism and provides an important and unique experimental model system for studying virus-cell interactions within the central nervous system. bdv surface glycoprotein (g) plays a critical role in virus cell entry via receptor-mediated endocytosis, and therefore, g is a critical determinant of virus tissue and cell tropism. however, the specific cell pathways involved ... | 2009 | 19656886 |
| mucosal lesions in a sheep infected with the border disease virus (bdv). | a 28-week-old sheep was presented at the animal hospital because of chronic emaciation, anemia and slight diarrhea. due to poor general condition and bad prognosis the animal was euthanized and submitted for postmortem investigation. multiple erosions and ulcerations were found in the dorsal region of the tongue, the pharynx, the hard palate, in the esophagus and the ruminal pillars. histologically, these lesions consisted of necrosuppurative inflammation. the animal was tested positive for pest ... | 2009 | 19653163 |
| role of borna disease virus in neuropsychiatric illnesses: are we inching closer? | the biological cause of psychiatric illnesses continues to be under intense scrutiny. among the various neurotropic viruses, borna disease virus (bdv) is another virus that preferentially targets the neurons of the limbic system and has been shown to be associated with behavioural abnormalities. presence of various bdv markers, including viral rna, in patients with affective and mood disorders have triggered ongoing debate worldwide regarding its aetiopathogenic relationship. this article analys ... | 2009 | 19584498 |
| alzheimer's disease and infection: do infectious agents contribute to progression of alzheimer's disease? | infection with several important pathogens could constitute risk factors for cognitive impairment, dementia, and alzheimer's disease (ad) in particular. this review summarizes the data related to infectious agents that appear to have a relationship with ad. infections with herpes simplex virus type 1, picornavirus, borna disease virus, chlamydia pneumoniae, helicobacter pylori, and spirochete were reported to contribute to the pathophysiology of ad or to cognitive changes. based on these reports ... | 2009 | 19560105 |
| a short target real-time rt-pcr assay for detection of pestiviruses infecting cattle. | a rapid single step real-time duplex taqman rt-pcr was developed for detection of bovine viral diarrhoea virus (bvdv)-1, bvdv-2 and border disease virus (bdv). based on alignment of available and newly generated partial 5'-utr nucleotide sequences, one forward and two reverse primers were designed, which amplify a 104bp pcr product. two taqman probes labelled with different fluorochromes were designed to detect bvdv-1/bvdv-2 and bdvs, respectively. the assay was able to detect a selection of str ... | 2009 | 19523981 |
| first report of bvdv circulation in sheep in argentina. | pestiviruses are capable of infecting a wide range of animals within the order artyodactila. currently, the genus pestivirus includes bovine viral diarrhea virus 1 (bvdv-1) and 2 (bvdv-2), border disease virus (bdv), and classical swine fever virus (csfv). bvdv-1, bvdv-2 and bdv are able to cross species barrier to infect a wide range of hosts, whereas csfv is restricted to domestic pigs and wild boars. in argentina, 70% of cattle are seropositive to bvdv. although there were some serological st ... | 2009 | 19501923 |
| seroprevalence of antibodies against pestiviruses in small ruminants in the netherlands. | in this study, a serological survey was performed to determine the prevalence of pestivirus (bovine viral diarrhea virus (bvdv) and border disease virus (bdv)) infected small ruminants herds in the netherlands. after random selection of sheep farms, a sample size was determined to detect a 5% herd prevalence. 13 out of 29 farms were tested seropositive using an elisa which detects antibodies directed against the non structural protein 3 (ns3) of pestiviruses. this resulted in a seroprevalence fo ... | 2009 | 19480144 |
| antigenic differentiation of classical swine fever viruses in china by monoclonal antibodies. | the phylogenetic diversity of classical swine fever virus (csfv) in china has been extensively studied previously, with the report of the classification of chinese csfvs into four subgroups within two of the established genotypes, but the antigenic differences amongst chinese csf viruses still remain unknown. to address this issue, 21 csfv field strains isolated in china between 1996 and 2006 were grown in cell culture and characterized in comparison with two chinese reference strains: a virulen ... | 2009 | 19428750 |
| mutation of the protein kinase c site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity. | understanding the pathogenesis of infection by neurotropic viruses represents a major challenge and may improve our knowledge of many human neurological diseases for which viruses are thought to play a role. borna disease virus (bdv) represents an attractive model system to analyze the molecular mechanisms whereby a virus can persist in the central nervous system (cns) and lead to altered brain function, in the absence of overt cytolysis or inflammation. recently, we showed that bdv selectively ... | 2009 | 19424436 |
| second-site mutations in borna disease virus overexpressing viral accessory protein x. | the x protein of borna disease virus (bdv) is an essential factor that regulates viral polymerase activity and inhibits apoptosis of persistently infected cells. we observed that a bdv mutant which carries an additional x gene replicated well in cell culture only after acquiring second-site mutations that selectively reduced expression of the endogenous x gene. in rat brains, the virus acquired additional mutations which inactivated the ectopic x gene or altered the sequence of x. these results ... | 2009 | 19420156 |
| detection of border disease virus in fetuses, stillbirths, and newborn lambs from natural and experimental infections. | the purpose of the present study was to evaluate the use of enzyme-linked immunosorbent assay (elisa) antigen detection in blood or fetal fluids and reverse transcription polymerase chain reaction (rt-pcr) amplification in tissues for routine laboratory diagnosis of border disease virus (bdv) infection. samples from 67 fetuses, 6 stillbirths, and 11 lambs from 25 commercial flocks with suspicion of bdv abortion and 3 fetuses, 7 stillbirths, and 15 lambs obtained from an experimental infection wi ... | 2009 | 19407084 |
| heat shock cognate protein 70 controls borna disease virus replication via interaction with the viral non-structural protein x. | borna disease virus (bdv) is a non-segmented, negative-sense rna virus and has the property of persistently infecting the cell nucleus. bdv encodes a 10-kda non-structural protein, x, which is a negative regulator of viral polymerase activity but is essential for virus propagation. recently, we have demonstrated that interaction of x with the viral polymerase cofactor, phosphoprotein (p), facilitates translocation of p from the nucleus to the cytoplasm. however, the mechanism by which the intrac ... | 2009 | 19397879 |
| [expressing borna disease virus phosphoprotein in pc-12 cell and its influence on the cell proliferation]. | to establish stable expressing system of borna disease virus (bdv) phosphoprotein in pc-12 cells, and then study its influence on cell proliferation of pc-12 cells. | 2009 | 19388275 |
| gene expression of the tgf-beta family in rat brain infected with borna disease virus. | crnp5, a variant of borna disease virus (bdv), has stronger pathogenesis in rats than the related variant crp3, although only 4 amino acids in the whole genome are different. as a first step to clarify the differential pathogenesis between the variants, the present study focused on examining the expression of the transforming growth factor (tgf)-beta family in the brain of rats infected with bdv. the main results were as follows. (1) bdv infection, irrespective of the variant, up-regulates tgf-b ... | 2009 | 19376261 |
| detection and analysis of borna disease virus in chinese patients with neurological disorders. | borna disease virus (bdv) is a neurotropic rna virus that is known to cause neurological disturbances in various animal species, potentially even humans. however, the association between bdv infection and human neurological disorders remains unclear. | 2009 | 19364367 |
| interferon-gamma prevents death of bystander neurons during cd8 t cell responses in the brain. | t cells restricted to neurotropic viruses are potentially harmful as their activity may result in the destruction of neurons. in the borna disease virus (bdv) model, antiviral cd8 t cells entering the brain of infected mice cause neurological disease but no substantial loss of neurons unless the animals lack interferon-gamma (ifn-gamma). we show here that glutamate receptor antagonists failed to prevent bdv-induced neuronal loss in ifn-gamma-deficient mice, suggesting that excitotoxicity resulti ... | 2009 | 19359516 |
| changes in borna disease virus genome with adaptation to host. | the crnp5 variant of borna disease virus (bdv) has stronger pathogenesis than the crp3 variant in which only 4 nucleotides in the whole genome are different. the crp3 is produced by 3 passages in rat brains of bdv, whereas the crnp5 is produced by 5 passages in mouse brains after 2 passages in rat brains of the bdv. thymidylic acids at nt 3608 and 3673 were replaced by cytidylic acids during 3 passages in mice. three passages in mice caused replacement of adenylic acid at nt 7936 by guanylic aci ... | 2009 | 19358894 |
| broad tissue and cell tropism of avian bornavirus in parrots with proventricular dilatation disease. | avian bornaviruses (abv), representing a new genus within the family bornaviridae, were recently discovered in parrots from north america and israel with proventricular dilatation disease (pdd). we show here that closely related viruses are also present in captive european parrots of various species with pdd. the six abv strains that we identified in clinically diseased birds are new members of the previously defined abv genotypes 2 and 4. viruses of both genotypes readily established persistent ... | 2009 | 19297496 |
| borna disease virus: a unique pathogen and its interaction with intracellular signalling pathways. | borna disease virus (bdv) is a neurotropic rna virus that establishes non-cytolytic persistent infection in the central nervous system of warm-blooded animals. depending on the host species and the route of infection, bdv persistence can modulate neuronal plasticity and animal behaviour and/or may provoke a t cell-mediated immunopathological reaction with high mortality. therefore, bdv functions as a model pathogen to study persistent virus infection in the central nervous system. here, we revie ... | 2009 | 19290912 |
| seroprevalence and characterization of pestivirus infections in small ruminants and new world camelids in switzerland. | the seroprevalence of pestivirus infections in small ruminants and new world camelids in switzerland was determined. in 5'059 sera of sheep from 382 herds, 503 sera of goats from 54 herds and 109 sera of alpacas and lamas from 53 herds, population prevalences of 16.1% (sheep), 25.4% (goats) and 4.6% (new world camelids), respectively, were found. in order to determine the source of infection, the serological reactions were further characterized by cross-neutralization against two pestiviruses re ... | 2009 | 19263380 |
| binding properties of gp1 protein of borna disease virus. | the surface glycoprotein (g) of borna disease virus (bdv) plays central roles in the process of viral entry. bdv g is cleaved by cellular furin-like proteases into two components, gp1 and gp2. although gp1 is involved in the virus entry into cells, the binding activity of gp1 to cells is unknown. therefore, we expressed the wild-type gp1 and a variety of gp1 deletion mutants that were flag-tagged at the c-terminus in human embryonic kidney 293t cells. these proteins were then purified using an a ... | 2009 | 19262042 |
| crystal structure of the borna disease virus matrix protein (bdv-m) reveals ssrna binding properties. | borna disease virus (bdv) is a neurotropic enveloped rna virus that causes a noncytolytic, persistent infection of the central nervous system in mammals. bdv belongs to the order mononegavirales, which also includes the negative-strand rna viruses (nsvs) ebola, marburg, vesicular stomatitis, rabies, mumps, and measles. bdv-m, the matrix protein (m-protein) of bdv, is the smallest m-protein (16.2 kda) among the nsvs. m-proteins play a critical role in virus assembly and budding, mediating the int ... | 2009 | 19237566 |
| protein x of borna disease virus inhibits apoptosis and promotes viral persistence in the central nervous systems of newborn-infected rats. | borna disease virus (bdv) is a neurotropic member of the order mononegavirales with noncytolytic replication and obligatory persistence in cultured cells and animals. here we show that the accessory protein x of bdv represents the first mitochondrion-localized protein of an rna virus that inhibits rather than promotes apoptosis induction. rat c6 astroglioma cells persistently infected with wild-type bdv were significantly more resistant to death receptor-dependent and -independent apoptotic stim ... | 2009 | 19211764 |
| [study on molecular epidemiology of borna disease virus in zunyi regions of guizhou province]. | in order to study the epidemiology of borna disease virus (bdv) in zunyi region and its surrounding regions in guizhou province. | 2008 | 19173966 |
| [epidemiological investigation on natural infection to borna disease virus (bdv) among horses in yili, xinjiang]. | to investigate the epidemiological pattern of borna disease virus (bdv) infection in horses and to analyze the phylogenetic tree of derived bdv in yili, xinjiang. | 2008 | 19173935 |
| phylogeny, classification and evolutionary insights into pestiviruses. | the genus pestivirus comprises four established species: bovine viral diarrhoea viruses 1 (bvdv-1) and 2 (bvdv-2), border disease virus (bdv), and classical swine fever virus (csfv); and a tentative species, pestivirus of giraffe. additional pestiviruses have been identified and suggested for recognition as novel subgroups/species. to achieve a reliable phylogeny as the basis for classification of pestiviruses, a molecular dataset of 56 pestiviruses and 2089 characters, comprising the 5'utr, com ... | 2009 | 19167739 |
| borna disease virus requires cholesterol in both cellular membrane and viral envelope for efficient cell entry. | borna disease virus (bdv), the prototypic member of the family bornaviridae within the order mononegavirales, provides an important model for the investigation of viral persistence within the central nervous system (cns) and of associated brain disorders. bdv is highly neurotropic and enters its target cell via receptor-mediated endocytosis, a process mediated by the virus surface glycoprotein (g), but the cellular factors and pathways determining bdv cell tropism within the cns remain mostly un ... | 2009 | 19129439 |
| seroprevalence and risk factors for the presence of ruminant pestiviruses in the dutch swine population. | swine can be infected with classical swine fever virus (csfv), as well as ruminant pestiviruses: bovine viral diarrhoea virus (bvdv), and border disease virus (bdv). cross-reactions between pestiviruses occur, both regarding protective immunity and in diagnostic tests. the presence of bvdv and bdv in a swine population may thus affect the transmission of csfv, but also the diagnosis of a csfv infection. in this study, the seroprevalence against bvdv and bdv in two categories of swine, sows and f ... | 2009 | 19128896 |