Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| comparison of cobas® hpv and anyplex™ ii hpv28 assays for detecting and genotyping human papillomavirus. | persistent infection with high-risk human papillomavirus (hpv-hr) is a recognized cause of cervical cancer. the aim of this study was to compare analytical and clinical performances of the cobas® hpv and anyplex™ ii hpv28 assays for hpv detection and genotyping. a total of 94 cervical samples were tested. for hpv-hr, the results agreed very well (94.68%), with 100% agreement when detecting cin2+. the anyplex™ ii hpv28 assay detected more genotypes than the cobas® hpv test, but their clinical per ... | 2017 | 28336133 |
| modulating the dna damage response to improve treatment response in cervical cancer. | cervical cancer is the fourth most common cause of cancer-related death in women worldwide and new therapeutic approaches are needed to improve clinical outcomes for this group of patients. current treatment protocols for locally advanced and metastatic disease consist of ionising radiation and chemotherapy. chemoradiation induces cytotoxic levels of dna double-strand breaks, which activates programmed cell death via the dna damage response (ddr). cervical cancers are unique given an almost excl ... | 2017 | 28336131 |
| human papillomavirus as prognostic marker with rising prevalence in neck squamous cell carcinoma of unknown primary: a retrospective multicentre study. | patients with neck squamous cell carcinomas of unknown primary tumour (nsccup) present with lymph node metastasis without evidence for a primary tumour. most patients undergo an aggressive multimodal treatment, which induces severe, potentially unnecessary toxicity. primary tumours of nsccup can be hidden in the oropharynx. human papillomavirus (hpv) is causally involved in a subgroup of oropharyngeal squamous cell carcinomas (opscc) associated with early lymph node metastasis and good prognosis ... | 2017 | 28335889 |
| genotype distribution characteristics of multiple human papillomavirus in women from the taihu river basin, on the coast of eastern china. | there is limited data on the genotype distribution of human papillomavirus (hpv) in the taihu river basin, home to 1.29 million people on the coast of eastern china. this study evaluated the prevalence and genotypes among different female age groups in this region. | 2017 | 28335818 |
| the burden of hpv-related diseases in italy, 2001-12. | human papillomavirus (hpv) infection is the main cause of cervical cancer and plays a relevant role in the development of genital warts and of the cancer of penis and anus, head/neck, oropharynx and genitourinary system. the aim of this study is the evaluation of hospitalizations due to hpv-related pathologies in 2001-12 in italy. | 2017 | 28334854 |
| association of hiv status with local immune response to anal squamous cell carcinoma: implications for immunotherapy. | the programmed cell death protein 1 (pd-1) and programmed death-ligand 1 (pd-l1) pathway play an important immunosuppressive role in cancer and chronic viral infection, and have been effectively targeted in cancer therapy. anal squamous cell carcinoma (scc) is associated with both human papillomavirus and hiv infection. to date, patients with hiv have been excluded from most trials of immune checkpoint blocking agents, such as anti-pd-1 and anti-pd-l1, because it was assumed that their antitumor ... | 2017 | 28334399 |
| adjuvant human papillomavirus vaccination for secondary prevention: a systematic review. | human papillomavirus (hpv) vaccination is recommended for children and younger adults but not older adults or those with prior hpv exposure, leaving a large portion of the population at risk for hpv-mediated disease. emerging data suggest a possible role for vaccination as an adjuvant treatment for individuals with hpv-related clinical disease. | 2017 | 28334393 |
| associations of human papillomavirus (hpv) genotypes with high-grade cervical neoplasia (cin2+) in a cohort of women living with hiv in burkina faso and south africa. | to describe associations of high-risk human papillomavirus (hr-hpv) with high-grade cervical intraepithelial neoplasia (cin2+) in women living with hiv (wlhiv) in burkina faso (bf) and south africa (sa). | 2017 | 28333966 |
| proteflazid® and local immunity in diseases caused by human papillomavirus, herpesvirus and mixed urogenital infections. | reporting of clinical trials results for proteflazid® in the drug formulation suppositories and vaginal swabs soaked in the solution of the drug to the local immunity of the female reproductive tract. | 2017 | 28333902 |
| clinician and patient acceptability of self-collected human papillomavirus testing for cervical cancer screening. | to evaluate clinician and patient attitudes toward home self-collected human papillomavirus (hpv) testing for cervical cancer screening. | 2017 | 28332888 |
| changing hpv vaccination rates in bisexual and lesbian women. | human papillomavirus (hpv) vaccination rates continue to be below national targets for women and lower in some sexual minorities. hpv is a primary causal agent in cervical cancer, from which members of the lesbian and bisexual community mistakenly believe they are at low risk. this study characterized rates of hpv vaccination in women based on their sexual orientation. | 2017 | 28332774 |
| practices and attitudes of missouri school nurses regarding immunization records and select immunizations of graduating high school seniors. | school nurses play a key role in maintaining a healthy student population, and one of their roles includes maintaining vaccination records. further, they can play an important role in advocating for human papillomavirus (hpv) and meningococcal vaccination for students. all missouri public high school nurses were sent an electronic survey addressing the knowledge, attitudes, and practices regarding immunization records and hpv and meningococcal vaccination of high school seniors. approximately 75 ... | 2017 | 28332065 |
| nucleic acid sensing with enzyme-dna binding protein conjugates cascade and simple dna nanostructures. | a versatile and universal dna sensing platform is presented based on enzyme-dna binding protein tags conjugates and simple dna nanostructures. two enzyme conjugates were thus prepared, with horseradish peroxidase linked to the dimeric single-chain bacteriophage cro repressor protein (hrp-sccro) and glucose oxidase linked to the dimeric headpiece domain of escherichia coli laci repressor protein (gox-dhp), and used in conjunction with a hybrid ssdna-dsdna detection probe. this probe served as a s ... | 2017 | 28331958 |
| legislative activity related to the human papillomavirus (hpv) vaccine in the united states (2006-2015): a need for evidence-based policy. | state-based policies to mandate hpv vaccination are politically challenging and have received broad criticisms. there is a critical need to understand the legislative activities that underpin subsequent policy implementation. the objective of this policy analysis was to analyze state legislation that focused on hpv vaccination from 2006-2015. a content analysis was conducted among primary sources of legislative data from hpv vaccine-related bills, including using the national conference of state ... | 2017 | 28331378 |
| sequence-based approach for rapid identification of cross-clade cd8+ t-cell vaccine candidates from all high-risk hpv strains. | human papilloma virus (hpv) is the primary etiological agent responsible for cervical cancer in women. although in total 16 high-risk hpv strains have been identified so far. currently available commercial vaccines are designed by targeting mainly hpv16 and hpv18 viral strains as these are the most common strains associated with cervical cancer. because of the high level of antigenic specificity of hpv capsid antigens, the currently available vaccines are not suitable to provide cross-protection ... | 2016 | 28330110 |
| acitretin for the treatment of recalcitrant plantar warts. | plantar warts caused by human papilloma virus (hpv)may be challenging to treat when conventionalmodalities fail. we report a case of severely recalcitrantplantar warts, successfully treated with oral acitretinand topical 40% urea cream. | 2017 | 28329527 |
| increased hpv l1 gene methylation and multiple infection status lead to the difference of cervical epithelial cell lesion in different ethnic women of xinjiang, china. | human papillomavirus (hpv) l1 gene methylation deeply involved in the progression and heterogeneity of cervical cell epithelial lesions. the dna ploidy also represented the early lesions of cervical cell, and it was associated with different hpv infection status in different ethnic women. so, the research was to explore whether it was possible that hpv l1 gene methylation and hpv infection status as the risk factors to lead to the differences of cervical epithelial cells' lesions in different et ... | 2017 | 28328841 |
| human papillomavirus first and second generation vaccines -current status and future directions. | it has been more than 10 years that the first prophylactic papillomavirus vaccine became available, although distribution has been mainly limited to the more affluent countries. the first two vaccines have been a great success, hundreds of millions of women and a much smaller number of men have been vaccinated ever since. in a few countries with high vaccination coverage, in particular australia but also parts of great britain and others, clinical impact of vaccination programs is already visibl ... | 2017 | 28328521 |
| pembrolizumab for platinum- and cetuximab-refractory head and neck cancer: results from a single-arm, phase ii study. | purpose there are no approved treatments for recurrent/metastatic head and neck squamous cell carcinoma refractory to platinum and cetuximab. in the single-arm, phase ii keynote-055 study, we evaluated pembrolizumab, an anti-programmed death 1 receptor antibody, in this platinum- and cetuximab-pretreated population with poor prognosis. methods eligibility stipulated disease progression within 6 months of platinum and cetuximab treatment. patients received pembrolizumab 200 mg every 3 weeks. imag ... | 2017 | 28328302 |
| [assessment of the pilot program for cervical cancer screening by health visitors]. | within the tender (6.1.3.a-13/1-2013-0001) supported by the european union, we wished to involve health visitors into the organized cervical cancer screening program. | 2017 | 28328247 |
| hpv16 dna and integration in normal and malignant epithelium: implications for the etiology of laryngeal squamous cell carcinoma. | molecular evidence suggests that human papillomavirus (hpv) has a role in the etiology of oropharyngeal squamous cell carcinoma. however, the role of hpv in laryngeal squamous cell carcinoma (lscc) is unclear. | 2017 | 28327951 |
| whole-genome analysis of human papillomavirus types 16, 18, and 58 isolated from cervical precancer and cancer samples in chinese women. | human papillomavirus (hpv) types 16, 18 and 58 are ranked the top three high-risk hpv types for cervical intraepithelial neoplasia (cin) and invasive carcinoma. we aimed to evaluate the diversity of hpv16, hpv18, and hpv58 genetic variants by hpv capture technology combined with next generation sequencing. 295, 73, and 148 variations were observed in 51 hpv16, 7 hpv18, and 11 hpv58 genomes, respectively. hpv16 isolates were predominantly of the a variant lineage, and sublineage a4 (asian) was th ... | 2017 | 28325903 |
| current and emerging molecular tests for human papillomavirus-related neoplasia in the genomic era. | laboratory tests have a key role in preventing human papillomavirus (hpv)-driven carcinomas and in guiding therapeutic interventions. an understanding of the virology, immunology, and carcinogenesis of hpv is essential for choosing appropriate diagnostic test modalities and developing new and even more effective cancer prevention strategies. hpv infects basal epithelial cells on multiple surfaces and induces carcinoma primarily in the cervix and the oropharynx. hpv types are stratified as high r ... | 2017 | 28325688 |
| hpv-16 variants' impact on uterine cervical cancer response to radiotherapy: a descriptive pilot study. | although the large impact of human papilloma virus (hpv) in cervical cancer is established, its place as a therapeutic target is new and according to the growing literature, could be promising. in the present study, radiosensitivity's difference based on hpv-16 variants is assessed. | 2017 | 28325620 |
| consensus statement from 17 relevant japanese academic societies on the promotion of the human papillomavirus vaccine. | 2017 | 28325478 | |
| the presence of human papillomavirus (hpv) in placenta and/or cord blood might result in th2 polarization. | the purpose of this study was to evaluate if an early exposure to human papillomavirus (hpv) during the prenatal period or infancy could result in hpv16-specific t helper (th) responses resembling those of adults with hpv-induced lesions. we tested hpv16-specific cell-mediated immunity (cmi) in children born with hpv-positive umbilical cord blood and/or placenta or having persistent oral hpv infection and in constantly oral hpv-negative controls. peripheral blood mononuclear cells from 33 childr ... | 2017 | 28324192 |
| cervical cancer screening intervals and management for women living with hiv: a risk benchmarking approach. | we suggested cervical cancer screening strategies for women living with hiv (wlhiv) by comparing their precancer risks to general population women, and then compared our suggestions with current centers for disease control and prevention (cdc) guidelines. | 2017 | 28323758 |
| the performance of human papillomavirus biomarkers in predicting anal high-grade squamous intraepithelial lesions in gay and bisexual men. | we evaluate the performance of human papillomavirus (hpv) biomarkers in prediction of anal histological high-grade squamous intraepithelial lesions (hsil) in gay and bisexual men (gbm) in sydney, australia. | 2017 | 28323757 |
| the prognostic value of extranodal extension in human papillomavirus-associated oropharyngeal squamous cell carcinoma. | extranodal (or extracapsular) extension (ene) is an adverse prognostic factor in patients with head and neck cancers who undergo primary surgery. however, the significance of ene in human papillomavirus (hpv)-positive oropharyngeal squamous cell carcinoma (opscc) is not well established, and single-institution studies have not established that ene predicts inferior outcome. the authors investigated the prognostic value of ene in hpv-positive patients who underwent primary surgery and whether adj ... | 2017 | 28323338 |
| the cost of implementing two small media interventions to promote hpv vaccination. | to estimate the cost of implementing lay health worker delivered print-based photonovella intervention and ipad-based tailored interactive multimedia intervention (timi) to promote human papillomavirus (hpv) vaccine uptake and completion among hispanic parents of daughters 9-17years old. | 2017 | 28322881 |
| association between parental hpv knowledge and intentions to have their daughters vaccinated. | human papillomavirus (hpv) 16 and 18 causes 66% of cervical cancers (dunne et al., 2014). vaccination during adolescence can prevent hpv-associated cervical cancers, yet less than half of adolescent girls are vaccinated. this study examined the association between hpv knowledge and parental intentions to vaccinate daughters against hpv. a retrospective, cross-sectional, national data set from the 2006-2007 health information national trends survey (hints) was used. a multivariate multinomial log ... | 2016 | 28322641 |
| a survey of wisconsin pediatricians' knowledge and practices regarding the human papillomavirus vaccine. | objective the human papillomavirus (hpv) is common and carries a significant burden of disease. this is increasingly apparent in males with the rising incidence of hpv-related oropharyngeal cancer. unfortunately, vaccination rates remain poor and are lowest in males. it is unclear if pediatricians are aware of the alarming rise of hpv-mediated head and neck cancers and the disproportionate effect on males. study design this investigation used a cross-sectional descriptive survey research design. ... | 2017 | 28322122 |
| hpv in larynx squamous cell carcinoma: new serotypes and survival study within 10-year follow-up. | objective to determine the presence of human papillomavirus (hpv) in head and neck squamous cell carcinoma, specifically in the larynx without the bias of other sublocations, and to describe the different serotypes of hpv and their impact on overall and disease-free survival after 10-year follow-up. study design retrospective case series with chart review of ear, nose, and throat oncologic database. setting academic tertiary care hospital. subjects a total of 123 samples of larynx squamous cell ... | 2017 | 28322111 |
| adolescent participation in hpv vaccine clinical trials: are parents willing? | approximately one-quarter of human papillomavirus (hpv) infections are acquired by adolescents, with a higher burden among racial/ethnic minorities. however, racial/ethnic minorities have been underrepresented in previous hpv vaccine trials. ongoing and future hpv vaccine optimization trials would benefit from racially- and ethnically-diverse sample of adolescent trial participants. this study examined factors influencing parental willingness to consent to their adolescents' participation in hpv ... | 2017 | 28321649 |
| adjusted particle size eliminates the need of linkage of antigen and adjuvants for appropriated t cell responses in virus-like particle-based vaccines. | since the discovery of the first virus-like particle (vlp) derived from hepatitis b virus in 1980 (1), the field has expanded substantially. besides successful use of vlps as safe autologous virus-targeting vaccines, the powerful immunogenicity of vlps has been also harnessed to generate immune response against heterologous and even self-antigens (2-4). linking adjuvants to vlps displaying heterologous antigen ensures simultaneous delivery of all vaccine components to the same antigen-presenting ... | 2017 | 28321220 |
| hpv-independent differentiated vulvar intraepithelial neoplasia (dvin) is associated with an aggressive clinical course. | differentiated vulvar intrapeithelial neoplasia (dvin) is an human papillomavirus (hpv)-independent precursor of squamous cell carcinoma (scc), and the aim of this study was to better characterize its natural history. cases of dvin were identified from the pathology archives. outcomes of patients with dvin only, without associated invasive scc, were compared with a cohort of patients with high-grade squamous intraepithelial lesion [hsil(vin3)]. eighteen patients diagnosed with dvin with adjacent ... | 2017 | 28319571 |
| reactogenicity of cervarix and gardasil human papillomavirus (hpv) vaccines in a randomized single blind trial in healthy uk adolescent females. | one hundred and ninety eight females aged 12-15 y were enrolled in an observer-blinded randomized trial to assess the immunogenicity and reactogenicity of the tetravalent hpv vaccine gardasil® (group 2), in comparison to the bivalent hpv vaccine, cervarix® (group 1), which was routinely offered in the national vaccination schedule at the time. participants were blinded to treatment group until all 3 vaccinations had been given, while laboratory staff were masked during testing. for the majority ... | 2017 | 28319456 |
| oral viral infections: diagnosis and management. | this article focuses on common viral infections in the oral cavity with associated systemic manifestations. discussed are the clinical features, histopathology, diagnosis, treatment, and prevention of viral infections in oral cavity. this will be a useful aid for general practitioners and other dental personnel wanting to expand their pathologic knowledge. this article discusses herpes simplex, varicella zoster, mononucleosis, cytomegalovirus, enteroviruses, rubeola, rubella, mumps, and human pa ... | 2017 | 28317570 |
| epidemiology of oral and maxillofacial infections. | dental caries and periodontal disease are the most common dental infections and are constantly increasing worldwide. distribution, occurrence of dental caries, gingivitis, periodontitis, odontogenic infections, antibiotic resistance, oral mucosal infections, and microbe-related oral cancer are important to understand the public impact and methods of controlling such disease. distribution of human papilloma virus and human immunodeficiency virus -related oral cancers in the us population is prese ... | 2017 | 28317563 |
| analyzing esophageal squamous cell papillomas for the presence of human papilloma virus. | human papilloma virus (hpv) infection can be a predisposing condition for the development of squamous cell papilloma (scp) of the esophagus, which can progress to dysplasia and to carcinoma as a result of chronic infection. the aim of the present study was to search for the presence of hpv in the esophageal scp, and to genotype the detected hpv. | 2017 | 28316321 |
| sensitivity and specificity of antibodies against hpv16 e6 and other early proteins for the detection of hpv16-driven oropharyngeal squamous cell carcinoma. | to determine the sensitivity and specificity of hpv16 serology as diagnostic marker for hpv16-driven oropharyngeal squamous cell carcinoma (opscc), 214 hnscc patients from germany and italy with fresh-frozen tumor tissues and sera collected before treatment were included in this study. hundred and twenty cancer cases were from the oropharynx and 94 were from head and neck cancer regions outside the oropharynx (45 oral cavity, 12 hypopharynx and 35 larynx). serum antibodies to early (e1, e2, e6 a ... | 2017 | 28316084 |
| 2016 international meeting of the global virus network. | the global virus network (gvn) was established in 2011 in order to strengthen research and responses to current viral causes of human disease and to prepare against new viral pandemic threats. there are now 38 gvn centers of excellence and 6 affiliate laboratories in 24 countries. gvn scientists meet annually to learn about each other's current research, address collaborative priorities and plan future programs. the 2016 meeting was held from october 23-25 in hokkaido, japan, in partnership with ... | 2017 | 28315708 |
| identification of an atypical etiological head and neck squamous carcinoma subtype featuring the cpg island methylator phenotype. | head and neck squamous cell carcinoma (hnscc) is broadly classified into hnscc associated with human papilloma virus (hpv) infection, and hpv negative hnscc, which is typically smoking-related. a subset of hpv negative hnsccs occur in patients without smoking history, however, and these etiologically 'atypical' hnsccs disproportionately occur in the oral cavity, and in female patients, suggesting a distinct etiology. to investigate the determinants of clinical and molecular heterogeneity, we per ... | 2017 | 28314692 |
| prevalence of cervical infection and genotype distribution of human papilloma virus among females in da nang, vietnam. | the goal of the present study was to determine the prevalence and distribution of high-risk human papilloma virus (hpv) genotypes in women from two districts in and around da nang city, vietnam. | 2017 | 28314288 |
| evaluation of p16/ki-67 dual-stained cytology as triage test for high-risk human papillomavirus-positive women. | the aim of this study was to evaluate the clinical utility of p16/ki-67 dual staining, for the identification of cin in high-risk hpv-positive women from a non-responder screening cohort. p16/ki-67 dual staining, pap cytology, and hpv16/18 genotyping were performed on physician-taken liquid-based samples from 495 women who tested high-risk hpv positive on self-sampled material (prohtect-3b study). different triage strategies involving p16/ki-67 dual staining were evaluated for sensitivity, speci ... | 2017 | 28304400 |
| influence of human papillomavirus on the clinical presentation of oropharyngeal carcinoma in the united states. | much of what is known about the significance of human papillomavirus (hpv) in oropharyngeal squamous cell carcinoma is derived from single-institution retrospective studies, post hoc analyses of tissue specimens from clinical trials, and tissue bank studies with a small sample size. the objective of this study is to investigate the impact of hpv on the frequency and clinical presentation of oropharyngeal carcinoma in a large, national sample with information from patients who underwent hpv testi ... | 2017 | 28304083 |
| e6/e7-p53-pou2f1-cthrc1 axis promotes cervical cancer metastasis and activates wnt/pcp pathway. | cervical cancer is an infectious cancer and the most common gynecologic cancer worldwide. e6/e7, the early genes of the high-risk mucosal human papillomavirus type, play key roles in the carcinogenic process of cervical cancer. however, little was known about its roles in modulating tumor microenvironment, particular extracellular matrix (ecm). in this study, we found that e6/e7 could regulate multiple ecm proteins, especially collagen triple helix repeat containing 1 (cthrc1). cthrc1 is highly ... | 2017 | 28303973 |
| multiplex polymerase chain reaction for the detection of high-risk-human papillomavirus types in formalin-fixed paraffin-embedded cervical tissues. | detecting high-risk-human papillomavirus (hpv) types has become an integral part of the cervical cancer screening programmes. this study aimed to develop a multiplex polymerase chain reaction (pcr) for identification of hpv types 16 and 18 along with the beta globin gene in formalin-fixed and paraffin-embedded cervical biopsy specimens. a total of 59 samples from patients with cervical abnormalities were tested. hpv 16 positivity was 50% in cervical cancers and 52.9% in cervical intraepithelial ... | 2017 | 28303830 |
| human papillomavirus and chlamydia trachomatis infection in gyneco-obstetric outpatients from a mexican hospital. | human papillomavirus (hpv) and chlamydia trachomatis are the most frequent sexually transmitted infections, usually asymptomatic. persistent infection with high-risk hpv types and other cofactors such as the concomitant infection with c. trachomatis can represent a higher risk to develop cervical lesions; therefore, screening with sensitive methods could aid to identify women at risk. | 2017 | 28303822 |
| dysregulated expression of microrna-150 in human papillomavirus-induced lesions of k14-hpv16 transgenic mice. | high-risk human papillomavirus (hpv) infection is one of the major causes of infection-related cancers worldwide. micrornas (mirnas) are a family of non-coding rnas (ncrnas), whose dysregulated levels may cause an aberrant expression of genes involved in oncogenic pathways and consequently lead to cancer development. this is the case of the mirna-150 (mir-150), whose expression in hpv-induced lesions remains unclear and the present work aims to clarify it. we employed k14-hpv16 mice, which expre ... | 2017 | 28302562 |
| rna chromogenic in situ hybridization assay with clinical automated platform is a sensitive method in detecting high-risk human papillomavirus in squamous cell carcinoma. | detection of active human papillomavirus (hpv) is clinically important, as its presence has been shown to correlate with favorable clinical outcomes and better response to treatment in oropharyngeal squamous cell carcinomas (scc). using a clinical automated platform, we compared the performance of commercially available hpv dna and rna in situ hybridization (ish) probes in archival tissues of 57 scc. importantly, a clinical automated platform gives 1) consistent and reproducible results for hpv ... | 2017 | 28302536 |
| beneficial effects of a coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women. | to assess the effect of a 12-day treatment using a vaginal gel based on niosomes containing hyaluronic acid, ß-glucan, alpha-glucan oligosaccharide, coriolus versicolor, asian centella, azadirachta indica and aloe vera on vaginal microbiota, cervical epithelization and vaginal health. | 2017 | 28302110 |
| target population for the screening of human papillomavirus (hpv) and anal carcinoma precursor lesions - results from a pilot study in hiv-infected males with sexual risk factors. | ninety-five percent of precursor lesions -high-grade squamous intraepithelial lesions (hsil) and anal intraepithelial neoplasms (ain)- and their progression to squamous anal cancer (ac) are induced by high-risk hpv (hr-hpv) serotypes 16 and 18. their incidence is higher particularly in hiv-infected male patients who have sex with other males (hiv-msm) (144/100,000/patients/year). | 2017 | 28301946 |
| human papillomavirus vaccination and genital warts in young indigenous australians: national sentinel surveillance data. | to examine the impact of the national human papillomavirus (hpv) vaccination program (available to girls and women [12-26 years] since 2007 and to boys [12-15 years] since 2013) on the number of diagnoses of genital warts in australian aboriginal and torres strait islander (indigenous) people. | 2017 | 28301790 |
| gtl001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific cd8+ t cell responses leading to tumor regression. | prophylactic vaccines are available for women and girls not yet infected with hpv, but women already infected with hpv need a treatment to prevent progression to high-grade cervical lesions and cancer. gtl001 is a bivalent therapeutic vaccine for eradicating hpv-infected cells that contains hpv16 e7 and hpv18 e7 both fused to detoxified adenylate cyclase from bordetella pertussis, which binds specifically to cd11b+ antigen-presenting cells. this study examined the ability of therapeutic vaccinat ... | 2017 | 28301611 |
| identification of optimal reference genes for normalization of rt-qpcr data in cancerous and non-cancerous tissues of human uterine cervix. | this study aimed to identify the most stably expressed reference genes from a panel of 32 candidate genes for normalization of reverse transcription-quantitative real-time polymerase chain reaction data in cancerous and non-cancerous tissues of human uterine cervix. overall, pum1, ywhaz, and rplp0 were identified as the most stably expressed genes in paired cancerous and non-cancerous tissues. the results were further stratified by the state of malignancy of the tissues, histopathological type o ... | 2017 | 28301252 |
| knowledge, attitude, and experience of cervical cancer and screening among sub-saharan african female students in a uk university. | cervical cancer is one of the major diseases that affect women of child bearing age. its main cause is the human papilloma virus; although, other associated factors have been evidenced to increase its risk. pap-smear screening and vaccination which has been shown to be successful in reducing the incidence and prevalence of the disease in developed countries, has been neglected in developing countries due to lack of knowledge, misconceptions, and cultural beliefs. | 2017 | 28300047 |
| 2017 | 28300000 | ||
| associations of foxp3 gene polymorphisms with severe recurrent respiratory papillomatosis in korean patients. | foxp3 is the most dependable marker for regulatory t cells which play a major role in immune tolerance. foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. we studied the association of foxp3 polymorphisms in severe rrp patients. | 2017 | 28298239 |
| cost-effectiveness of cervical cancer screening methods in low- and middle-income countries: a systematic review. | the incidence of cervical cancer in low- and middle-income countries (lmics) is five times higher than that observed in high-income countries (hics). this discrepancy is largely attributed to the implementation of cytology-based screening programmes in hics. however, due to reduced health system infrastructure requirements, hpv testing (self- and provider-collected) and visual inspection with acetic acid (via) have been proposed as alternatives that may be better suited to lmics. knowing the rel ... | 2017 | 28297074 |
| endocervical adenocarcinoma with morphologic features of both usual and gastric types: clinicopathologic and immunohistochemical analyses and high-risk hpv detection by in situ hybridization. | the fourth edition of the world health organization classification set up new entities of endocervical adenocarcinoma (eca), namely the "usual type" and "gastric type." these 2 types are considered to be distinct histogenetically because of their differing immunophenotypes, human papillomavirus (hpv) status, and prognoses. usual-type ecas (u-ecas) are virtually always associated with high-risk human papillomavirus (hr-hpv) infection. gastric-type ecas (g-ecas) are believed not to be associated w ... | 2017 | 28296678 |
| response to: hpv vaccine and autoimmunity incidence of new-onset autoimmune disease in girls and women with pre-existing autoimmune disease after quadrivalent human papillomavirus vaccination: a cohort study. | 2017 | 28295767 | |
| traf3/cyld mutations identify a distinct subset of human papilloma virus-associated head and neck squamous cell carcinoma. | the incidence of human papillomavirus (hpv)-associated (hpv-positive) head and neck squamous cell carcinoma (hnscc) of the oropharynx has dramatically increased over the last decade and continues to rise. newly diagnosed hpv-positive hnsccs in the united states currently outnumber any other hpv-associated cancers, including cervical cancer. despite introduction of the hpv vaccine, the epidemic of hpv-positive hnscc is expected to continue for approximately 60 years. compared with patients who ha ... | 2017 | 28295222 |
| genetic alterations in traf3 and cyld that regulate nuclear factor κb and interferon signaling define head and neck cancer subsets harboring human papillomavirus. | 2017 | 28295216 | |
| prevalence of human papillomavirus infection among chilean women from 2012 to 2016. | here, we evaluated the prevalence of human papillomavirus (hpv) in two groups of chilean women. the first group consisted of 3235 women aged 18-64 years attended in six primary care centers of santiago. the second group consisted of 456 women 18-85 aged who consulted the gynaecology department of the reference hospital of santiago. samples were collected from october 2012 to february 2016. cervical swabs were analyzed both hpv genotyping by pcr and reverse line blot, and cervical cytology by pap ... | 2017 | 28294358 |
| human papillomavirus prevalence in mouthwashes of patients undergoing tonsillectomy shows dominance of hpv69, without the corresponding finding in the tonsils. | the role of human papillomavirus (hpv) in tonsillar squamous cell carcinomas (tscc) is of interest, since a considerable proportion of tscc in sweden and other western countries is hpv positive. nevertheless, the natural history of hpv in normal tonsils, and the progression from localized infection to pre-malignant lesion to cancer are poorly understood. the aim of this study was to investigate whether hpv types found in mouthwash samples correlated to those in tonsillar tissue from the same ind ... | 2017 | 28293975 |
| influence of high risk hpv genotype on colposcopic performance: a large prospective study demonstrates improved detection of disease with zedscan i, particularly in non-hpv 16 patients. | to assess the influence of high-risk human papilloma virus (hrhpv) genotyping on the detection of high-grade disease (cin2+) using colposcopic impression both with and without electrical impedance spectroscopy (zedscan i) as an adjunct. | 2017 | 28292693 |
| human papillomavirus vaccine update. | rates of cancers attributable to human papillomavirus (hpv) are rising. a safe and extremely effective vaccine is available to prevent many of these cancers. studies have shown that health care providers' recommendation to immunize is the most important factor in parents' decision. parents of all adolescent boys and girls should receive a strong and unequivocal recommendation to vaccinate their child against hpv at the 11- or 12-year-old well child visit. ideally, adolescents complete their hpv ... | 2017 | 28292448 |
| transoral robotic surgery with radial forearm free flap reconstruction: case control analysis. | the resection of large oropharyngeal tumors traditionally involves a lip-splitting mandibulotomy for adequate margin visualization and free flap reconstruction of the surgical defect. transoral robotic surgery (tors) has emerged as a technique that can resect large and complex oropharyngeal tumors, avoiding a lip-splitting approach. the aim of this study is to compare the lip-splitting mandibulotomy approach versus tors for the management of advanced stage oropharyngeal carcinomas. | 2017 | 28292318 |
| performing piety in sexual health research: gender, health and evangelical christianities in a mexican human papillomavirus (hpv) study. | recent research suggests that health surveillance experiences like clinical trial participation might have unanticipated social consequences. i investigate how evangelical christians participating in longitudinal, observational sexual health research incorporate that long-term medical surveillance into their religious practice. this exploratory research focuses on mexican cristianos' participation in the cuernavaca arm of the multinational 'human papillomavirus in men' ('him') study, which teste ... | 2017 | 28292201 |
| [buschke-löwenstein tumor]. | 2016 | 28292138 | |
| health professional feedback on hpv vaccination roll-out in a developing country. | worldwide, zambia has the highest cervical cancer incidence rates (58.4/100,000 per year) and mortality rates (36.2/100,000 per year). the human papilloma virus (hpv) vaccine is considered a vital preventative measure against cervical cancer, particularly in sub-saharan countries, such as zambia. past research suggests health professionals' experiences with hpv vaccination rollout can have practical implications for effective delivery. | 2017 | 28291647 |
| medullary carcinoma of the penis: a distinctive hpv-related neoplasm: a report of 12 cases. | a third to half of penile invasive squamous cell carcinomas are human papillomavirus (hpv) related. warty (condylomatous), warty-basaloid, and basaloid carcinomas are the most common subtypes associated with hpv. less frequent are clear cell and lymphoepithelioma-like carcinomas. here we report a novel penile tumor associated with hpv. twelve cases were selected from 1010 penile carcinomas, part of an international hpv detection study conducted at the institut català d'oncologia, barcelona, spai ... | 2017 | 28291123 |
| smarcb1 (ini-1)-deficient sinonasal carcinoma: a series of 39 cases expanding the morphologic and clinicopathologic spectrum of a recently described entity. | to more fully characterize the clinical and pathologic spectrum of a recently described tumor entity of the sinonasal tract characterized by loss of nuclear expression of smarcb1 (ini1), we analyzed 39 smarcb1-deficient sinonasal carcinomas collected from multiple medical centers. the tumors affected 23 males and 16 females with an age range of 19 to 89 years (median, 52). all patients presented with locally advanced disease (t3, n=5; t4, n=27) involving the sinuses (mainly ethmoid) with variabl ... | 2017 | 28291122 |
| deep sequencing of hpv e6/e7 genes reveals loss of genotypic diversity and gain of clonal dominance in high-grade intraepithelial lesions of the cervix. | human papillomavirus (hpv) is the carcinogen of almost all invasive cervical cancer and a major cause of oral and other anogenital malignancies. hpv genotyping by dideoxy (sanger) sequencing is currently the reference method of choice for clinical diagnostics. however, for samples with multiple hpv infections, genotype identification is singular and occasionally imprecise or indeterminable due to overlapping chromatograms. our aim was to explore and compare hpv metagenomes in abnormal cervical c ... | 2017 | 28288568 |
| lymph node activation by pet/ct following vaccination with licensed vaccines for human papillomaviruses. | while pet using f-fdg is most commonly used for imaging malignant tumors, vaccination is known to cause transient inflammation of lymph nodes inducing positive findings on f-fdg pet scans. the pattern, magnitude, and duration of lymph node activation following vaccination have not been clearly defined. furthermore, the addition of adjuvants to vaccines can further enhance the immune response. the presented study was designed to define lymph node activation following administration of the food an ... | 2017 | 28288041 |
| a protocol for a cluster randomised feasibility study of an adolescent incentive intervention to increase uptake of hpv vaccination among girls. | uptake of the human papillomavirus (hpv) vaccine in the uk is good, but there are pockets of the community who remain unprotected. immunisation teams usually require written parental consent for a girl to receive the vaccine. evidence suggests that uptake of the vaccine might be improved by promoting consent form return (if returned, forms are likely to grant consent). incentivising girls to return consent forms is a promising approach to promoting consent form return. before testing the efficac ... | 2017 | 28286668 |
| prevalence of adeno-associated virus and human papillomavirus dna in iranian women with and without cervical cancer. | there is plenty of substantial evidence to support anti-tumor activity of viruses. adeno-associated virus (aav) may interact with human papillomavirus (hpv) to modify the risk of cervical neoplasia. the seroprevalence of aav among women with cervical cancer has been reported to be lower than healthy ones. in spite of this finding, detection of aav dna in cervical biopsies does not entirely support the inverse association between aav seropositivity and cervical cancer. this association is still c ... | 2017 | 28285965 |
| current and future techniques for human papilloma virus (hpv) testing in oropharyngeal squamous cell carcinoma. | despite a reduction in smoking and alcohol consumption, the incidence of oropharyngeal squamous cell carcinoma (opscc) is rising. this is attributed to human papilloma virus (hpv) infection and screening for hpv is now recommended in all cases of opscc. despite a variety of clinically available tests and new non-invasive test strategies there is no consensus on which technique is best. this review reports on current techniques for hpv detection in opscc and the clinical applicability of emerging ... | 2017 | 28285422 |
| prevalence and risk factors for human papillomavirus infection among chinese ethnic women in southern of yunnan, china. | dai is a major chinese ethnic minority group residing in rural areas of the southern part of yunnan. however, no data exist on the hpv prevalence and genotype distribution among dai women. | 2017 | 28284657 |
| the association between adverse pregnancy outcomes and maternal human papillomavirus infection: a systematic review protocol. | human papillomavirus (hpv) is the most prevalent genital infection, especially in young women of reproductive age. in vitro and animal model experiments provide compelling evidence of the harmful effect of hpv on pregnancy outcomes, but results from epidemiologic studies are inconclusive. we aim to determine the strength of the relationship between adverse pregnancy outcomes (apo) and hpv infection and assess its consistency across studies, by systematically reviewing the literature. | 2017 | 28284227 |
| geospatial planning and the resulting economic impact of human papillomavirus vaccine introduction in mozambique. | research has shown that the distance to the nearest immunization location can ultimately prevent someone from getting immunized. with the introduction of human papillomavirus (hpv) vaccine throughout the world, a major question is whether the target populations can readily access immunization. | 2017 | 28282648 |
| point-of-care sexually transmitted infection diagnostics: proceedings of the star sexually transmitted infection-clinical trial group programmatic meeting. | the goal of the point-of-care (poc) sexually transmitted infection (sti) diagnostics meeting was to review the state-of-the-art research and develop recommendations for the use of poc sti diagnostics. experts from academia, government, nonprofit, and industry discussed poc diagnostics for stis such as chlamydia trachomatis, human papillomavirus, neisseria gonorrhoeae, trichomonas vaginalis, and treponema pallidum. key objectives included a review of current and emerging technologies, clinical an ... | 2017 | 28282646 |
| control of immune escaped human papilloma virus is regained after therapeutic vaccination. | high-risk human papillomaviruses infect the basal cells of human epithelia. there it deploys several mechanisms to suppress pathogen receptor recognition signalling, impeding the immune system to control viral infection. furthermore, infected cells become more resistant to type i and ii interferon, tumour necrosis factor-α and cd40 activation, via interference with downstream programs halting viral replication or regulating the proliferation and cell death. consequently, some infected individual ... | 2017 | 28282583 |
| measures of economic advantage associated with hpv-positive head and neck cancers among non-hispanic black and white males identified through the national cancer database. | national trends show dramatic increases in the incidence of hpv-related head and neck squamous cell carcinomas (hnsccs) among black and white males. using cases identified through the national cancer data base, we assessed factors associated with hpv 16- or 16/18 positive hnsccs among non-hispanic black and white males diagnosed in the u.s. between 2009 and 2013. | 2017 | 28282541 |
| lifetime sexual assault and sexually transmitted infections among women veterans. | women veterans report a high prevalence of sexual assault. unfortunately, there are limited data on the reproductive health sequelae faced by these women. our objective was to evaluate the association between completed lifetime sexual assault (lsa) and sexually transmitted infections (stis) among a cohort of women veterans, adjusting for sexual risk behaviors. | 2017 | 28281918 |
| who is to blame? framing hpv to influence vaccination intentions among college students. | human papillomavirus (hpv) is a prevalent sexually transmitted infection (sti) among college students. although previous research has studied hpv-related health communication strategies using various framing techniques, the goal of this study is to test how two unique message frames-whether mentioning hpv as an sti and whether to attribute the cause of infection as external or internal-would influence young adults' intentions to receive the recommended hpv vaccine. results indicate that gender a ... | 2017 | 28281783 |
| cervical carcinogenesis and immune response gene polymorphisms: a review. | the local immune response is considered a key determinant in cervical carcinogenesis after persistent infection with oncogenic, high-risk human papillomavirus (hpv) infections. genetic variation in various immune response genes has been shown to influence risk of developing cervical cancer, as well as progression and survival among cervical cancer patients. we reviewed the literature on associations of immunogenetic single nucleotide polymorphism, allele, genotype, and haplotype distributions wi ... | 2017 | 28280748 |
| the cost of developing a computerized tailored interactive multimedia intervention vs. a print based photonovella intervention for hpv vaccine education. | mobile technology is opening new avenues for healthcare providers to create and implement tailored and personalized health education programs. we estimate and compare the cost of developing an i-pad based tailored interactive multimedia intervention (timi) and a print based (photonovella) intervention to increase human papillomavirus (hpv) immunization. the development costs of the interventions were calculated using a societal perspective. direct cost included the cost of planning the study, co ... | 2017 | 28279866 |
| introduction of molecular hpv testing as the primary technology in cervical cancer screening: acting on evidence to change the current paradigm. | since being introduced in the 1940s, cervical cytology - despite its limitations - has had unequivocal success in reducing cervical cancer burden in many countries. however, we now know that infection with human papillomavirus (hpv) is a necessary cause of cervical cancer and there is overwhelming evidence from large-scale clinical trials, feasibility studies and real-world experience that supports the introduction of molecular testing for hpv as the primary technology in cervical cancer screeni ... | 2017 | 28279264 |
| approaches for triaging women who test positive for human papillomavirus in cervical cancer screening. | substantial evidence exists to support the introduction of molecular testing for human papillomavirus (hpv) as the primary technology in cervical cancer screening. while hpv testing is much more sensitive than cytology for detection of high-grade precancerous lesions, it is less specific. to improve efficiency, it is therefore recommended that a specific test (like cytology) be used in triaging hpv positive women to colposcopy. a number of studies have been conducted that support the use of cyto ... | 2017 | 28279257 |
| rna extraction method is crucial for human papillomavirus e6/e7 oncogenes detection. | human papillomavirus (hpv) dna testing plays a main role in the management of cervical cancer, however to improve the specificity in cervical screening, there is a need to develop and validate different approaches that can identify women at risk for progressive disease. nowadays, mrna expression of viral e6 and e7 hpv oncogenes stands up as a potential biomarker to improve cervical screening. we aimed to validate a method for rna extraction, detect hpv mrna expression and, assess the relationshi ... | 2017 | 28279212 |
| chinese shang ring male circumcision: a review. | chinese shang ring adult male circumcision (sc) is a safe and effective procedure which is easy to learn and to perform. by a specially designed small device, male circumcision (mc) can be performed in 5 min. compared with conventional adult mc (cc), sc has shorter operation time, less blood loss, less pain score, higher appearance satisfaction rate, and lower complication rate. sc was first developed in china. as recent studies have demonstrated that mc reduced the risk of acquiring human immun ... | 2017 | 28278508 |
| surveillance of adverse events following immunisation in australia annual report, 2014. | this report summarises australian passive surveillance data for adverse events following immunisation (aefi) for 2014 reported to the therapeutic goods administration for 2014 and describes reporting trends over the 15-year period 1 january 2000 to 31 december 2014. there were 3,087 aefi records for vaccines administered in 2014; an annual aefi reporting rate of 13.2 per 100,000 population. there was a decline of 5% in the overall aefi reporting rate in 2014 compared with 2013. this decline in r ... | 2016 | 28278414 |
| hpv l1 and p16 expression in cin1 to predict future cin2. | to use the biomarkers human papillomavirus (hpv) l1 and p16 to develop an algorithm that could triage the individual patient with cin1 for the risk of progression. a total of 82 patients initially diagnosed with cin1 at peking university shenzhen hospital in china had their initial and follow-up paraffin-embedded tissue blocks immune-stained for hpv l1 capsid protein and p16. for cin1, any staining of abnormal epithelium was considered positive. all patients were followed until they developed ci ... | 2017 | 28277314 |
| "we've been together. we don't have it. we're fine." how relationship status impacts human papillomavirus vaccine behavior among young adult women. | vaccination against the human papillomavirus (hpv) has the potential to significantly reduce morbidity and mortality associated with genital warts and hpv-related cancers. however, hpv vaccination rates continue to be suboptimal among the "catch-up" population of 18- to 26-year-old women. one consistent risk factor for nonvaccination is being in a relationship. this study aimed to understand how relationship status and vaccination status impact risk perceptions and perceived need for the hpv vac ... | 2017 | 28277236 |
| molecular tests potentially improving hpv screening and genotyping for cervical cancer prevention. | human papillomavirus (hpv)-related cancers can be averted by type-specific vaccination (primary prevention) and/or through detection and ablation of precancerous cervical lesions (secondary prevention). this review presents current challenges to cervical cancer screening programs, focusing on recent molecular advances in hpv testing and potential improvements on risk stratification. areas covered: high-risk (hr)-hpv dna detection has been progressively incorporated into cervix cancer prevention ... | 2017 | 28277144 |
| using community engagement to develop a web-based intervention for latinos about the hpv vaccine. | human papillomavirus (hpv) infection is pervasive among sexually active women and men, and hispanic women are at particularly high risk as they have higher rates of invasive cervical cancer compared to other racial or ethnic groups in the united states. there is a need for interventions to increase hpv vaccination among this high-risk population. this study investigated how to modify a previously developed web-based intervention that provided individually tailored information about hpv to improv ... | 2017 | 28276945 |
| is extending screening intervals safe in hpv negative women? | greater sensitivity which lowers cancer incidence (rocco et al, lancet 2014), extended screening intervals, and prophylactic vaccination provide the rationale for high risk human papillomavirus (hr-hpv) testing to replace cytology as the primary test in cervical screening programmes both in the uk and internationally. zorzi et al report in the bjog, a timely cohort study from italy of primary hpv cervical screening, concluding that following primary hpv screening, three years is too soon for a r ... | 2017 | 28276149 |
| cervical cancer screening and treatment in uganda. | cervical cancer is the leading cause of cancer death among women in uganda. given the high prevalence of genital human papillomavirus infection, the current unavailability of radiotherapy, and the absence of a national cervical cancer prevention and control program, these deaths will likely increase. efforts to organize an effective cervical cancer screening and treatment program will require adequate financial resources, the development of infrastructure, training needed manpower, and surveilla ... | 2017 | 28275695 |