Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| ephrin receptor a2 is an epithelial cell receptor for epstein-barr virus entry. | epstein-barr virus (ebv) is causally associated with nasopharyngeal carcinoma, 10% of gastric carcinoma and various b cell lymphomas 1 . ebv infects both b cells and epithelial cells 2 . recently, we reported that epidermal growth factor and neuropilin 1 markedly enhanced ebv entry into nasopharyngeal epithelial cells 3 . however, knowledge of how ebv infects epithelial cells remains incomplete. to understand the mechanisms through which ebv infects epithelial cells, we integrated microarray and ... | 2018 | 29292383 |
| open splenectomy for varicella zoster induced spontaneous splenic rupture. | here we present a case of atraumatic splenic rupture secondary to varicella infection requiring emergency splenectomy. the presentation was as would be expected for epstein barr virus (ebv) related splenic injury, which is well documented in the literature. dermatological findings however suggested varicella zoster, and viral serology subsequently confirmed the diagnosis. | 2017 | 29291540 |
| lymphoepithelioma-like carcinoma of the large intestine: a case report and literature review. | lymphoepithelioma like carcinoma (lelc) is a well-known neoplastic lesion that mainly involves the stomach and which has been linked to epstein barr virus infection. there are exceptional cases of intestinal involvement by lelc, with 7 reported cases to date. we report a new case of lelc affecting the right colon and review the literature on this rare disorder, with special emphasis on pathogenesis, molecular features and differential diagnosis. | 2018 | 29290316 |
| myastenia and small doses of ionizing radiation: experience of successful use of rituximab for treatment of an irradiated with myasthenia gravis. | a clinical case of the rituximab («rituksim», «mabthera») use to treat a man affected by the chornobyl npp acci dent with malignant resistant form of myasthenia gravis in conjunction with chronic mixed infection by toxoplasma, epstein barr virus, cytomegalovirus and herpes simplex virus is described. in the dynamics of two year's observa tion the clinical efficacy of monoclonal antibodies was shown as the main symptoms stabilization and reducing doses of glucocorticoid and anticholinergic therap ... | 2017 | 29286523 |
| impact of chronic blood viral infection on lymphocyte telomere length in chornobyl clean-up workers in a remote period after radiation exposure. | to assess whether telomere length in lymphocytes of chornobyl clean up workers at a late period 30 years after the exposure to ionizing radiation is influenced by a chronic blood viral infection and to determine role of viral carriage in cellular senescence. | 2017 | 29286521 |
| low uric acid level increases the risk of infectious mononucleosis and this effect is more pronounced in women. | infectious mononucleosis (im) due to epstein-barr virus infection is common. uric acid (ua) is an important endogenous antioxidant. to the best of our knowledge, the association between ua and im has not been comprehensively investigated to date. the aim of the present study was to investigate this association in chinese patients. a total of 95 patients (47 men and 48 women) with im were recruited, along with 95 healthy controls. clinical data were classified by patient sex. receiver operating c ... | 2017 | 29285370 |
| elevated pretreatment platelet distribution width and platelet count predict poor prognosis in nasopharyngeal carcinoma. | previous studies have demonstrated that platelets play a multifaceted role in cancer progression and metastasis. however, the value of platelet indices for predicting survival in nasopharyngeal carcinoma (npc) patients remains unknown. the aim of this study was to evaluate the predictive significance of platelet indices in npc cases. | 2017 | 29285316 |
| cadherin 6 is activated by epstein-barr virus lmp1 to mediate emt and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is an epithelial malignancy, which is notorious among head-and-neck cancers with its metastatic feature. epstein-barr virus (ebv) infection plays a fundamental role in npc development with the mechanism is not well understood. here we demonstrate that ebv oncoprotein lmp1 drives emt and metastasis of npc by reactivating the adhesion molecule, cadherin 6 (cdh6), which normally occurs in embryogenesis with unknown role in npc. cdh6 was found to be upregulated in lmp1 ... | 2017 | 29284791 |
| prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum epstein-barr virus dna copy number in predicting distant metastasis in patients with n1 nasopharyngeal carcinoma. | according to the 7th edition of the american joint committee on cancer (ajcc) staging system, over 50% of patients with nasopharyngeal carcinoma (npc) have n1 disease at initial diagnosis. however, patients with n1 npc are relatively under-researched, and the metastasis risk of this group is not well-stratified. this study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node (gtvnd) and pretreatment serum copy number of epstein-barr virus (ebv) dna in p ... | 2017 | 29284539 |
| loss of rasgrp1 in humans impairs t-cell expansion leading to epstein-barr virus susceptibility. | inherited ctps1, cd27, and cd70 deficiencies in humans have revealed key factors of t-lymphocyte expansion, a critical prerequisite for an efficient immunity to epstein-barr virus (ebv) infection. rasgrp1 is a t-lymphocyte-specific nucleotide exchange factor known to activate the pathway of map kinases (mapk). a deleterious homozygous mutation in rasgrp1 leading to the loss rasgrp1 expression was identified in two siblings who both developed a persistent ebv infection leading to hodgkin lymphoma ... | 2017 | 29282224 |
| a rare case of classical hodgkin lymphoma diagnosed 10 years after liver transplant. | posttransplant lymphoproliferative disorders (ptld) represent a rare and potentially life-threatening complication after liver transplantation. classical hodgkin lymphoma (chl), with an incidence of approximately 1.8-3.4% of all ptld cases, represents a minority of ptld, mainly presenting as a late transplant complication. the main risk factors for the development of ptld are epstein-barr virus (ebv) infection and intensive immunosuppression. however, other risk factors like hepatitis c virus ma ... | 2017 | 29279693 |
| other iatrogenic immunodeficiency-associated lymphoproliferative disorder, hodgkin type, following epstein-barr viral hepatitis in a patient with rheumatoid arthritis. | a 59-year-old man with an 18-year history of rheumatoid arthritis who had been treated with steroids, methotrexate, and infliximab presented with a high-grade fever, cervical lymphadenopathy, and hepatosplenomegaly. epstein-barr virus (ebv) hepatitis was diagnosed based on the liver histology and ebv antibody titer. the symptoms improved temporarily, but five months later, the fever, skin rash, jaundice, and thrombocytopenia relapsed. bone marrow and liver biopsies demonstrated infiltration with ... | 2017 | 29279493 |
| infectious mononucleosis. | in brief a two-step infection by the epstein-barr virus accounts for the characteristic features of infectious mononucleosis (im). new serologic tests for viral antigens exist, but a rapid kit test for heterophil antibody usually suffices to confirm the diagnosis. general management is supportive only. splenic rupture is very rare, almost never fatal if diagnosed early, and, in most cases, is probably best treated by splenectomy. athletes tend to recover from im faster than nonathletes. when the ... | 1996 | 29275769 |
| lymphoblastoids cell lines - derived ipsc line from a 26-year-old myotonic dystrophy type 1 patient carrying (ctg)200 expansion in the dmpk gene: chuqi001-a. | human immortalized epstein-barr virus (ebv) lymphoblastoids cells line (lcls) from a 26-year- old male affected by an adult form of myotonic dystrophy type 1 (dm1) disease and carrying 200 ctg repeats mutation in the blood was used to generate induced pluripotent stem cells (ipscs) using the sendai virus expressing klf4, oct4, sox2 and c-myc. the resulting ipscs were ebv free, expressed the pluripotency markers, could be differentiated into the three germ layers in vitro, had a normal karyotype, ... | 2017 | 29274549 |
| epstein-barr virus exanthem in an adult patient with myelodysplastic syndrome. | 2017 | 29274098 | |
| inverse correlation of vδ2+ t-cell recovery with ebv reactivation after haematopoietic stem cell transplantation. | epstein-barr virus (ebv) reactivation remains a life-threatening complication in recipients of a haploidentical haematopoietic stem cell transplantation (haplohsct). reconstitution of adaptive t lymphocytes is generally compromised at the early stages following transplant, suggesting an important role of other effector cells in preventing ebv infection. our previous studies demonstrated that recovery of cd4- cd8- t cells negatively correlated with ebv reactivation after haplohsct. in this prospe ... | 2018 | 29270985 |
| disseminated tuberculosis and chronic mucocutaneous candidiasis in a patient with a gain-of-function mutation in signal transduction and activator of transcription 1. | in humans, recessive loss-of-function mutations in stat1 are associated with mycobacterial and viral infections, whereas gain-of-function (gof) mutations in stat1 are associated with a type of primary immunodeficiency related mainly, but not exclusively, to chronic mucocutaneous candidiasis (cmc). we studied and established a molecular diagnosis in a pediatric patient with mycobacterial infections, associated with cmc. the patient, daughter of a non-consanguineous mestizo mexican family, had axi ... | 2017 | 29270166 |
| mirna-36 inhibits kshv, ebv, hsv-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (ifitm1). | kaposi's sarcoma-associated herpesvirus (kshv) is etiologically associated with all forms of kaposi's sarcoma worldwide. little is currently known about the role of micrornas (mirnas) in kshv entry. we recently demonstrated that kshv induces a plethora of host cell mirnas during the early stages of infection. in this study, we show the ability of host cell novel mir-36 to specifically inhibit kshv-induced expression of interferon induced transmembrane protein 1 (ifitm1) to limit virus infection ... | 2017 | 29269892 |
| low cd4 cells and viral co-infection increase the risk of vain: use of scca1 and ki67 as diagno-prognostic biomarkers. | this study evaluated the correlation of scca1, ki67 and cd4 cell expressions and classified vaginal smears in individuals co-infected with human immunodeficiency virus (hiv), herpes simplex virus 2 (hsv2), epstein barr virus (ebv) and human papilloma virus (hpv). this crossectional study included 173 participants within the age range of 20-70 years. vaginal smears were stained by papanicolaou technique and classified into high-grade squamous cell intraepithelial lesion (hsil), low-grade squamous ... | 2017 | 29269193 |
| functional assessment of the bmpr2 gene in lymphoblastoid cell lines from graves' disease patients. | in this study, we analysed the possible influence of the c.419-43delt bmpr2 variant in patients with graves' disease (gd), in a molecular basis, focusing our efforts on possible alterations in the mrna processing and synthesis. the molecular assessment of this variant in patients with gd would shed light on the association between the bmpr2 gene and the disease. the variant was detected in 18%, 55% and 10% of patients with pulmonary arterial hypertension, gd and in general population, respective ... | 2017 | 29266775 |
| the optimal cumulative cisplatin dose in nasopharyngeal carcinoma patients receiving additional induction chemotherapy. | to clarify the optimal cumulative cisplatin dose (ccd) in locoregionally-advanced nasopharyngel carcinoma (npc) patients receiving induction chemotherapy (ic) plus concurrent chemoradiotherapy (ccrt). using the npc-specific database from the established big-data intelligence platform at sun yat-sen university cancer center, 583 non-disseminated, locoregionally-advanced npc patients receiving ic plus ccrt were enrolled. propensity score matching (psm) analysis was conducted to control for confoun ... | 2017 | 29266526 |
| rediscovery of nf-κb signaling in nasopharyngeal caicrnoma: how genetic defects of nf-κb pathway interplay with ebv in driving oncogenesis? | nasopharyngeal carcinoma (npc) is a unique ebv-associated subtype of head and neck cancer, which has the highest incidence in southern china and eastern south asia. the interaction between genetic risk factors and environmental challenge, have been considered to contribute to the development of nasopharyngeal carcinogenesis. constitutive activation of nf-κb signaling has been seen in npc tissues and is associated with unfavorable prognosis. recently, several whole exome sequencing study consiste ... | 2017 | 29266238 |
| serological evidence of borrelia burgdorferi infection in mexican patients with facial palsy. | facial palsy is the most frequent manifestation of neuroborreliosis in the united states, europe, and asia, whereas in mexico, its frequency is unknown. | 2017 | 29265112 |
| aggressive natural killer cell leukemia: a case report. | aggressive natural killer (nk) cell leukemia is a rare hematological malignancy. it often presents with a rapidly declining clinical course and a poor prognosis with a median survival of a few months. we report the case of a 23-year-old man with high fever, enlarged lymph nodes, splenomegaly, cytopenia, liver dysfunctions, coagulation disorders and hemophagocytosis. computed tomography scan showed right lung shadow. lung involvement was considered. histological examination of the lung was not pe ... | 2017 | 29263706 |
| efficient translation of ebv dna polymerase contributes to the enhanced lytic replication phenotype of m81 ebv. | epstein-barr virus (ebv) is linked to development of both lymphoid and epithelial malignancies worldwide. the m81 strain of ebv isolated from a chinese patient with nasopharyngeal carcinoma (npc) demonstrates spontaneous lytic replication and high-titer virus production in comparison to the prototype b95-8 ebv strain. genetic comparisons have previously been performed between m81 and b95-8 ebv in order to determine if the hyper-lytic property of m81 is associated with sequence differences in ess ... | 2017 | 29263273 |
| [value of cd3+cd4+ t cell count in prediction of viral infection after hematopoietic stem cell transplantation in patients severe aplastic anemia]. | to explore the value of cd3+cd4+ t cell count in prediction of viral infections after allogeneic hematopoietic stem cell transplantation(allo-hsct) in the patients with severe aplastic anemia(saa). | 2017 | 29262912 |
| [lymphocytic clonal expansion in adult patients with epstein-barr virus-associated lymphoproliferative disease]. | to explore the lymphocytic clonal expansion in adult patients with epstein-barr virus-associated lymphoproliferative diseases (ebv+lpd), and to investigate the experimental methods for ebv+lpd cells so as to provide a more objective measure for the diagnosis, classification and prognosis in the early stage of this disease. | 2017 | 29262893 |
| b cell receptor activation and chemical induction trigger caspase-mediated cleavage of pias1 to facilitate epstein-barr virus reactivation. | epstein-barr virus (ebv) in tumor cells is predominately in the latent phase, but the virus can undergo lytic reactivation in response to various stimuli. however, the cellular factors that control latency and lytic replication are poorly defined. in this study, we demonstrated that a cellular factor, pias1, restricts ebv lytic replication. pias1 depletion significantly facilitated ebv reactivation, while pias1 reconstitution had the opposite effect. remarkably, we found that various lytic trigg ... | 2017 | 29262325 |
| species-specific functions of epstein-barr virus nuclear antigen 2 (ebna2) reveal dual roles for initiation and maintenance of b cell immortalization. | epstein-barr virus (ebv) and related lymphocryptoviruses (lcv) from non-human primates infect b cells, transform their growth to facilitate life-long viral persistence in the host, and contribute to b cell oncogenesis. co-evolution of lcv with their primate hosts has led to species-specificity so that lcvs preferentially immortalize b cells from their natural host in vitro. we investigated whether the master regulator of transcription, ebv nuclear antigen 2 (ebna2), is involved in lcv species-sp ... | 2017 | 29261800 |
| whole transcriptome profiling reveals major cell types in the cellular immune response against acute and chronic active epstein-barr virus infection. | epstein-barr virus (ebv) is a common human pathogen that infects over 95% of the population worldwide. in the present study, the whole transcriptome microarray data were generated from peripheral blood mononuclear cells from chinese children with acute infectious mononucleosis (aim) and chronic active ebv infection (caebv) that were also compared with a publicly available microarray dataset from a study of american college students with aim. our study characterized for the first time a broad spe ... | 2017 | 29259291 |
| identification of t-cell receptor expression in ebv-positive neoplastic cells in extranodal nk/t-cell lymphoma, nasal-type and comparison with t-cell receptor gene rearrangement by biomed-2 assay. | the cellular lineage of extranodal nk/t-cell lymphoma, nasal-type (enktl) is determined by expression of t-cell receptor (tr) or tr gene rearrangement. in enktl, from tr immunohistochemistry it may often be difficult to decide whether tr-positive cells are tumor cells or not, especially when tr is expressed in a subset of tumor cells. to analyze tr expression pattern and tr rearrangement in t-lineage enktl, we performed double immunofluorescence staining for epstein-barr virus-encoded small rnas ... | 2017 | 29258904 |
| coinfection with epstein-barr virus (ebv), human papilloma virus (hpv) and polyoma bk virus (bkpyv) in laryngeal, oropharyngeal and oral cavity cancer. | most research providing evidence for the role of oncogenic viruses in head and neck squamous cell carcinoma (scc) development is focused on one type of virus without analyzing possible interactions between two or more types of viruses. the aim of this study was to analyse the prevalence of co-infection with human papillomavirus (hpv), epstein-barr virus (ebv) and polyoma bk virus (bkpyv) in oral, oropharyngeal and laryngeal squamous cell carcinomas in polish patients. the correlations between vi ... | 2017 | 29257122 |
| human papillomavirus (hpv)-associated lymphoepithelioma-like carcinoma of the vagina and anal canal: a rare variant of squamous cell carcinoma. | lymphoepithelioma-like carcinoma (lelc) is an uncommon variant of squamous cell carcinoma, which is histologically identical to lymphoepithelial carcinoma of the nasopharynx. lelcs have been reported at a variety of sites, including the stomach, salivary gland, thymus, cervix, endometrium, breast, skin, bladder, and lung. we report 2 lelcs of the vagina and 1 of the anal canal, the first report of lelc at the latter site. all 3 neoplasms were diffusely positive with p16 (block-type immunoreactiv ... | 2017 | 29257037 |
| a rare cause of gastrointestinal bleeding in the post-transplant setting. | post-transplant lymphoproliferative disorder (ptld) is a life-threatening complication noted after solid organ transplantation and is frequently related to epstein-barr virus infection. the present case highlights an unusual presentation of ptld - gastrointestinal bleeding - in the absence of systemic symptoms. | 2017 | 29255810 |
| hodgkin's lymphoma in crohn's disease treated with infliximab. | lymphoproliferative disorders, particularly non-hodgkin's and hodgkin's lymphomas, are rare in patients with inflammatory bowel diseases. the use of thiopurines and infection by epstein-barr virus are well-known cofactors that can raise its prevalence. other risk factors such as disease activity and biological treatment are the subject of discussion, without enough data in the literature to confirm a potential association. | 2017 | 29255769 |
| is it possible to develop cancer vaccines to neoantigens, what are the major challenges, and how can these be overcome? neoantigens: nothing new in spite of the name. | the term "neoantigen," as applied to molecules newly expressed on tumor cells, has a long history. the groundbreaking discovery of a cancer causing virus in chickens by rous over 100 years ago, followed by discoveries of other tumor-causing viruses in animals, suggested a viral etiology of human cancers. the search for other oncogenic viruses in the 1960s and 1970s resulted in the discoveries of epstein-barr virus (ebv), hepatitis b virus (hbv), and human papilloma virus (hpv), and continues unt ... | 2017 | 29254980 |
| two girl patients with medulloblastoma. case reports. | in childhood, the most common type of brain tumors is medulloblastoma, a highly malignant primary brain tumor that is found in the cerebellum or posterior fossa. the tumor mass increases and generates obstructive hydrocephalus. risk factors (that might be involved in some cases) include the genetic syndrome such as type 1 neurofibromatosis, exposure to ionizing radiation and epstein-barr virus. medulloblastoma is associated with recessively inherited turcot disease and with conditions as ataxia- ... | 2017 | 29250697 |
| lymphoproliferative disorder in a twin female teenager post kidney transplantation. | post-transplant lymphoproliferative disorder (ptld) is defined as a heterogeneous group of lymphoid and plasmocytic proliferations with variable malignant potential. they often arise in immunocompromised post solid organ transplant (sot) patients linked with epstein-barr virus (ebv) infection. clinical manifestations include fever, lymphadenopathy and organ involvement. diagnosis of ptld requires morphopathological tissue examination. treatment of ebv-related ptld in sot patients includes immuno ... | 2017 | 29250687 |
| plasma magnesium is inversely associated with epstein-barr virus load in peripheral blood and burkitt lymphoma in uganda. | epstein-barr virus (ebv) causes endemic burkitt lymphoma (ebl). ebv control was improved by magnesium (mg2+) supplementation in xmen, an x-linked genetic disease associated with mg2+ deficiency, high circulating ebv levels (viral loads), and ebv-related lymphomas. we, therefore, investigated the relationship between mg2+ levels and ebv levels and ebl in uganda. | 2017 | 29248801 |
| modulation of the tumor microenvironment by epstein-barr virus latent membrane protein 1 in nasopharyngeal carcinoma. | latent membrane protein 1 (lmp1) is a primary oncogene encoded by the epstein-barr virus, and various portions of lmp1 are detected in nasopharyngeal carcinoma (npc) tumor cells. lmp1 has been extensively studied since the discovery of its transforming property in 1985. lmp1 promotes cancer cell growth during npc development and facilitates the interaction of cancer cells with surrounding stromal cells for invasion, angiogenesis, and immune modulation. lmp1 is detected in 100% of pre-invasive np ... | 2017 | 29247573 |
| ebi2 receptor regulates myelin development and inhibits lpc-induced demyelination. | the g protein-coupled receptor ebi2 (epstein-barr virus-induced gene 2) is activated by 7α, 25-dihydroxycholesterol (7α25hc) and plays a role in t cell-dependant antibody response and b cell migration. abnormal ebi2 signaling is implicated in a range of autoimmune disorders; however, its role in the cns remains poorly understood. | 2017 | 29246262 |
| expression and clinical value of programmed cell death-ligand 1 (pd-l1) in diffuse large b cell lymphoma: a retrospective study. | the programmed cell death-1 (pd-1)/programmed cell death-ligand 1 (pd-l1) pathway inhibits the activation of t cells and plays a crucial role in the negative regulation of cellular and humoral immune responses. diffuse large b-cell lymphoma (dlbcl) is the most common lymphoid malignancy in adults. in the present study, we aimed to detect the expression of pd-l1 in dlbcl and to analyze its relationship with prognosis. | 2017 | 29246182 |
| an inflammatory myofibroblastic tumor in the transplanted liver displaying quick wash-in and wash-out on contrast-enhanced ultrasound: a case report. | inflammatory myofibroblastic tumor (imt) is an uncommon mesenchymal neoplasm, and its presence in a grafted liver is exceedingly rare. | 2017 | 29245287 |
| an extremely rare case of epstein-barr virus-associated gastric carcinoma with differentiation to neuroendocrine carcinoma. | epstein-barr virus (ebv)-associated gastric carcinoma (ebvgc) is defined as a neoplasm comprising monoclonal proliferation of ebv-infected gastric epithelial cells. although the typical histology is gastric carcinoma with lymphoid stroma (gcls), the histologic features of the tumor vary. we report herein the case of a 78-year-old man with multiple simultaneous ebvgcs revealing different histopathologic morphologies; one was mixed adenoneuroendocrine carcinoma (manec), and the other was gcls. bot ... | 2018 | 29244230 |
| symptomatic cerebrospinal fluid hiv-1 escape with no resistance-associated mutations following low-level plasma viremia. | the majority of neurologically symptomatic cerebrospinal fluid hiv-1 escape cases are connected with resistance-associated mutations and potentially explained by low cerebrospinal fluid antiretroviral concentrations. however, there are still significant knowledge gaps regarding the physiopathology and long-term management of neurosymptomatic viral escape. we report a case of parkinson-like syndrome following cerebrospinal fluid hiv-1 escape in a 40-year-old female patient with an history of pers ... | 2017 | 29243133 |
| clinical, viral and genetic characteristics of drug reaction with eosinophilia and systemic symptoms (dress) in shanghai, china. | dress is one of the most severe drug reactions. the aim of this retrospective study was to summarize the clinical presentation, genetic predisposition and prognostic factors of dress. a total of 52 patients with dress, who were inpatients at a medical referral centre in shanghai, china, from january 2011 to december 2016, were analysed retrospectively. all the patients had skin eruption, 83% had liver involvement, and ≤10% had other organ involvement. average cost of hospitalization was $5,511±3 ... | 2017 | 29242946 |
| a distinct subtype of epstein barr virus positive t/nk-cell lymphoproliferative disorder: adult patients with chronic active epstein barr virus infection-like features. | the characteristics of adult patients with chronic active epstein-barr virus infection (adult-onset caebv) are poorly recognized, hindering early diagnosis and an improved prognosis. adult-onset caebv (n = 54) diagnosed between 2005 and 2015 were conducted. adult-onset was defined as an estimated age of onset ≥15 years. to characterize the clinical features of adult-onset caebv, we compared them to those of pediatric-onset (estimated age of onset <15 years) patients (n = 75). we compared the pro ... | 2017 | 29242302 |
| early experience with clinimacs prodigy ccs (ifn-gamma) system in selection of virus-specific t cells from third-party donors for pediatric patients with severe viral infections after hematopoietic stem cell transplantation. | viral reactivation is a frequent complication of allogeneic hematopoietic stem cell transplantation especially in children. for refractory cases, rapid virus-specific t-cell therapy would be ideally implemented within a few days. over the course of a year in our pediatric cohort of 43 allogeneic transplantation, 9 patients fulfilled criteria for virus-specific t-cell therapy. viral infections were due to cytomegalovirus (cmv) in 3, epstein-barr virus (ebv) in 2, and adenovirus (adv) in 1 case, w ... | 2017 | 29239916 |
| lymphoepithelioma is a nonkeratinizing squamous cell carcinoma with epstein-barr virus infection in china. | the objective of this study is to investigate the histogenesis of lymphoepithelial carcinoma (lec) and its relationship with epstein-barr virus (ebv). | 2017 | 29237908 |
| pi3kδ activates e2f1 synthesis in response to mrna translation stress. | the c-myc oncogene stimulates ribosomal biogenesis and protein synthesis to promote cellular growth. however, the pathway by which cells sense and restore dysfunctional mrna translation and how this is linked to cell proliferation and growth is not known. we here show that mrna translation stress in cis triggered by the gly-ala repeat sequence of epstein-barr virus (ebv)-encoded ebna1, results in pi3kδ-dependent induction of e2f1 mrna translation with the consequent activation of c-myc and cell ... | 2017 | 29235459 |
| prevalence of epstein-barr virus dna and porphyromonas gingivalis in japanese peri-implantitis patients. | peri-implantitis (pi) is an inflammatory reaction associated with functional deterioration of supporting bones around the dental implant. recent studies suggested epstein-barr virus (ebv) is involved in the pathogenesis of periodontitis. we investigated the association between ebv and porphyromonas gingivalis in japanese pi patients. | 2017 | 29233156 |
| ebv-encoded mirnas target atm-mediated response in nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a highly invasive epithelial malignancy that is prevalent in southern china and southeast asia. it is consistently associated with latent epstein-barr virus (ebv) infection. in npc, mir-barts, the ebv-encoded mirnas derived from bamh1-a rightward transcripts are abundantly expressed and contribute to cancer development by targeting various cellular and viral genes. in this study, we establish a comprehensive transcriptional profile of ebv-encoded mirnas in a pan ... | 2017 | 29230817 |
| posttransplant lymphoproliferative disorders in kidney transplant recipients: a retrospective cohort analysis over two decades in hong kong. | to characterize the posttransplant lymphoproliferative disorders (ptld) including the epstein-barr virus (ebv) status, histological subgroups, site of occurrence and the clinical outcome in the chinese kidney transplant recipients. | 2017 | 29228580 |
| epstein-barr virus-positive extranodal marginal zone lymphoma of bronchial-associated lymphoid tissue in the posttransplant setting: an immunodeficiency-related (posttransplant) lymphoproliferative disorder? | posttransplant lymphoproliferative disorders (ptlds) are a heterogeneous group of hematolymphoid proliferations arising in the context of chronic immunosuppression. the common and indolent b-cell lymphomas, including extranodal marginal zone lymphomas (enmzls) of mucosa-associated lymphoid tissue (malt), are excluded from the category of ptld in the current world health organization classification. | 2017 | 29228090 |
| n-acetylcysteine (nac) ameliorates epstein-barr virus latent membrane protein 1 induced chronic inflammation. | chronic inflammation results when the immune system responds to trauma, injury or infection and the response is not resolved. it can lead to tissue damage and dysfunction and in some cases predispose to cancer. some viruses (including epstein-barr virus (ebv)) can induce inflammation, which may persist even after the infection has been controlled or cleared. the damage caused by inflammation, can itself act to perpetuate the inflammatory response. the latent membrane protein 1 (lmp1) of ebv is a ... | 2017 | 29228057 |
| prevalence and molecular profiling of epstein barr virus (ebv) among healthy blood donors from different nationalities in qatar. | the epstein-barr virus (ebv) is the causative agent of infectious mononucleosis. ebv is highly prevalent lymphotropic herpesvirus and has been linked to several malignancies. transmission is generally by oral secretions, but can be through blood transfusions and organ transplantations. this study aimed to determine the seroprevalence, viremia rates, and circulating genotypes of ebv in healthy blood donors in qatar. | 2017 | 29228016 |
| visualizing single-cell secretion dynamics with single-protein sensitivity. | cellular secretion of proteins into the extracellular environment is an essential mediator of critical biological mechanisms, including cell-to-cell communication, immunological response, targeted delivery, and differentiation. here, we report a novel methodology that allows for the real-time detection and imaging of single unlabeled proteins that are secreted from individual living cells. this is accomplished via interferometric detection of scattered light (iscat) and is demonstrated with laz3 ... | 2018 | 29227108 |
| epstein barr virus-associated smooth muscle tumour (ebv-smt) of the urinary bladder. | 2018 | 29226094 | |
| epstein-barr virus-specific immune control by innate lymphocytes. | epstein-barr virus (ebv) is a potent b cell transforming pathogen in humans. in most persistently ebv-infected individuals, potent cytotoxic lymphocyte responses prevent ebv-associated pathologies. in addition to comprehensive adaptive t cell responses, several innate lymphocyte populations seem to target different stages of ebv infection and are compromised in primary immunodeficiencies that render individuals susceptible to symptomatic ebv infection. in this mini-review, i will highlight the f ... | 2017 | 29225606 |
| reactivation of hemophagocytic lymphohistiocytosis triggered by antithymocyte globulin. | a 16-year-old boy with epstein-barr virus-associated hemophagocytic lymphohistiocytosis (hlh) underwent allogeneic hematopoietic stem cell transplantation after conditioning with fludarabine, melphalan, total body irradiation, and rabbit antithymocyte globulin (atg). a severe, persistent infusion reaction occurred after the initial administration of atg. investigations showed a rapid increase in the levels of liver enzymes and ferritin, and the reactivation of hlh was confirmed by marked hemopha ... | 2017 | 29225252 |
| oral methotrexate-related lymphoproliferative disease presenting with severe osteonecrosis of the jaw: a case report and literature review. | long-term methotrexate (mtx) treatment can cause mtx-related lymphoproliferative disorder (mtx-lpd). we experienced a case of mtx-lpd that was associated with severe osteonecrosis of the jaw mimicking medication-related osteonecrosis of the jaw. the patient was an 81-year-old woman with rheumatoid arthritis (ra) who was treated with mtx and bisphosphonate. after 7 years, she was referred to our department for the assessment of giant ulcer and exposure of the alveolar bone of the left maxilla. hi ... | 2017 | 29225245 |
| [clinicopathologic analysis of micronodular thymoma with lymphoid stroma]. | objective: to investigate the clinicopathologic features of micronodular thymoma with lymphoid stroma(mnt). methods: five cases of mnt diagnosed from january 2007 to december 2016 in henan provincial people's hospital were collected.hematoxylin-eosin staining and immunohistochemistry were used to evaluate the histological and immunophenotypic characteristics in 5 mnt cases. epstein-barr virus (ebv) status was detected by in situ hybridization for ebv-encoded small rna (eber). polymerase chain re ... | 2017 | 29224277 |
| posttransplant lymphoproliferative disorders in epstein-barr virus donor positive/recipient negative lung transplant recipients. | epstein-barr virus (ebv) donor positive/recipient negative (d+/r-) status is a significant risk factor for posttransplant lymphoproliferative disorder (ptld) in lung transplant. there are, however, no studies that identify the risk factors for ptld in the ebv d+/r- lung transplant population to guide the decision to proceed with an ebv-positive donor. | 2018 | 29223419 |
| rank expression in ebv positive nasopharyngeal carcinoma metastasis: a ready-to-treat target? | epstein barr virus (ebv) related nasopharyngeal carcinoma (npc), is an highly chemo- and radiosensitive endemic malignancy in southeast asia. more than one third of locally advanced cases relapse after curative treatment, especially because of bone, liver and lung metastases. lymphocyte sub-populations favour ebv-associated carcinogenesis and tumour progression and several strategies aim to reverse this phenomenon. receptor activator of nf-kb (rank) and its ligand (rankl), key regulator of bone ... | 2017 | 29221197 |
| epstein-barr virus in tumor-infiltrating b cells of myasthenia gravis thymoma: an innocent bystander or an autoimmunity mediator? | the thymus plays a key role in myasthenia gravis (mg), a b cell-mediated autoimmune disorder affecting neuromuscular junction. most mg patients have thymic abnormalities, including hyperplasia and thymoma, a neoplasm of thymic epithelial cells. epstein-barr virus (ebv) is associated with autoimmune diseases and tumors. recently, we showed ebv persistence and reactivation in hyperplastic mg thymuses, suggesting that ebv might contribute to intra-thymic b cell dysregulation in mg patients. here, w ... | 2017 | 29221139 |
| nasopharyngeal carcinoma risk prediction via salivary detection of host and epstein-barr virus genetic variants. | genetic susceptibility and epstein-barr virus (ebv) infection are important etiological factors in nasopharyngeal carcinoma (npc). in this study, in southern china, where npc is endemic, a single nucleotide polymorphism (snp) in the ebv-encoded rpms1 gene (locus 155391: g > a [g155391a]) and seven host snps (rs1412829, rs28421666, rs2860580, rs2894207, rs31489, rs6774494, and rs9510787) were confirmed to be significantly associated with npc risk in 50 npc cases versus 54 hospital-based controls ... | 2017 | 29221111 |
| systemic epstein-barr virus-positive t-cell lymphoproliferative disorders of childhood with fulminant leukocytosis and tumor lysis: a case report with autopsy findings. | systemic epstein-barr virus (ebv)-positive t-cell lymphoproliferative disorders (t-lpd) of childhood is an extremely rare disease characterized by an aggressive clinical course and very poor prognosis. we report an adolescent male with systemic ebv-positive t-lpd of childhood after primary ebv infection, resulting in a fatal clinical course within 9 days, along with autopsy findings. a 19-year-old male without an immunocompromised status presented with an acute onset of high fever, and was hospi ... | 2017 | 29218495 |
| authors reply to letter to the editor- in response to: "smit d, meyer d, maritz j, et al. polymerase chain reaction and goldmann-witmer coefficient to examine the role of epstein-barr virus in uveitis". | 2017 | 29215921 | |
| direct substrate identification with an analog sensitive (as) viral cyclin-dependent kinase (v-cdk). | viral cyclin-dependent kinases (v-cdks) functionally emulate their cellular cdk counterparts. such viral mimicry is an established phenomenon that we extend here through chemical genetics. kinases contain gatekeeper residues that limit the size of molecules that can be accommodated within the enzyme active site. mutating gatekeeper residues to smaller amino acids allows larger molecules access to the active site. such mutants can utilize bio-orthoganol atps for phosphate transfer and are inhibit ... | 2018 | 29215867 |
| epstein-barr virus-associated hemophagocytic lymphohistiocytosis mimicking lymphoma on fdg pet/ct. | a 15-year-old boy with fever, pancytopenia, and hepatosplenomegaly was diagnosed as hemophagocytic lymphohistiocytosis (hlh). f-fdg pet/ct showed hypermetabolic foci in the liver, spleen, and bone marrow, as well as multiple fdg-avid lymph nodes, which were highly suggestive of lymphoma. specimens from splenectomy depicted a large number of macrophages/histiocytes with hemophagocytosis of erythrocytes, without evidence of malignancy. considering increased epstein-barr virus (ebv) dna in peripher ... | 2018 | 29215415 |
| bone marrow involvement of epstein-barr virus-positive large b-cell lymphoma in a patient with angioimmunoblastic t-cell lymphoma. | 2018 | 29214764 | |
| the hedgehog signaling pathway emerges as a pathogenic target. | the hedgehog (hh) signaling pathway plays an essential role in the growth, development, and homeostatis of many tissues in vertebrates and invertebrates. much of what is known about hh signaling is in the context of embryonic development and tumor formation. however, a growing body of evidence is emerging indicating that hh signaling is also involved in postnatal processes such as tissue repair and adult immune responses. to that extent, hh signaling has also been shown to be a target for some p ... | 2017 | 29214147 |
| strong viral associations with sle among filipinos. | epstein-barr virus (ebv) is considered an important environmental factor in sle aetiology, but the relationship between sle and ebv in the filipino population is unknown. we tested associations between sle, lupus-associated autoantibodies and seropositivity for ebv and other herpes viruses in the filipino population. | 2017 | 29214036 |
| characterization of a suppressive cis-acting element in the epstein-barr virus lmp1 promoter. | latent membrane protein 1 (lmp1) is a major oncogene encoded by epstein-barr virus (ebv) and is essential for immortalization of b cells by the virus. previous studies suggested that several transcription factors, such as pu.1, rbp-jκ, nfκb, ebf1, ap-2 and stat, are involved in lmp1 induction; however, the means by which the oncogene is negatively regulated remains unclear. here, we introduced short mutations into the proximal lmp1 promoter that includes recognition sites for the e-box and ikaro ... | 2017 | 29213259 |
| tetraspanin cd63 bridges autophagic and endosomal processes to regulate exosomal secretion and intracellular signaling of epstein-barr virus lmp1. | the tetraspanin protein cd63 has been recently described as a key factor in extracellular vesicle (ev) production and endosomal cargo sorting. in the context of epstein-barr virus (ebv) infection, cd63 is required for the efficient packaging of the major viral oncoprotein latent membrane protein 1 (lmp1) into exosomes and other ev populations, and acts as a negative regulator of lmp1 intracellular signaling. accumulating evidence has also pointed to intersections of the endosomal and autophagy p ... | 2017 | 29212935 |
| severity of acute infectious mononucleosis correlates with cross-reactive influenza cd8 t-cell receptor repertoires. | fifty years after the discovery of epstein-barr virus (ebv), it remains unclear how primary infection with this virus leads to massive cd8 t-cell expansion and acute infectious mononucleosis (aim) in young adults. aim can vary greatly in severity, from a mild transient influenza-like illness to a prolonged severe syndrome. we questioned whether expansion of a unique hla-a2.01-restricted, cross-reactive cd8 t-cell response between influenza virus a-m158 (iav-m1) and ebv bmlf1280 (ebv-bm) could mo ... | 2017 | 29208744 |
| pik3ca mutations are associated with increased tumor aggressiveness and akt activation in gastric cancer. | pik3ca mutations are frequent in gastric cancer. however, their pathological and clinical implications are still unclear. we analyzed the clinicopathological characteristics according to the pik3ca mutation status of patients with stage ib-iv disease who underwent gastrectomy between may 2003 and dec. 2005 (cohort 1; n = 302) and of those with stage iv disease who received gastrectomy between jul. 2006 and dec. 2012 (cohort 2; n = 120). pik3ca mutations were detected in 40 patients (13.2%) in co ... | 2017 | 29207615 |
| herpesvirus and autophagy: "all right, everybody be cool, this is a robbery!" | autophagy is an essential vacuolar process of the cell, leading to lysosomal degradation and recycling of proteins and organelles, which is extremely important in maintaining homeostasis. multiple roles have been now associated with autophagy, in particular a pro-survival role in nutrient starvation or in stressful environments, a role in life span extension, in development, or in innate and adaptive immunity. this cellular process can also take over microorganisms or viral proteins inside autop ... | 2017 | 29207540 |
| report of a myocarditis outbreak among pediatric patients: human herpesvirus 7 as a causative agent? | the etiology of myocarditis in children has not yet been completely elucidated. | 2017 | 29206935 |
| etiology of sinonasal inverted papilloma: a narrative review. | sinonasal inverted papilloma (ip) is a benign and uncommon tumor of the nasal cavity and paranasal sinuses with a tendency for recurrence and even malignant transformation. though the morphology and clinical behavior of this lesion has been well described, its etiology remains controversial. | 2017 | 29204580 |
| lymphoepithelial carcinoma: a case report of a rare tumor of the larynx. | lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. it is extremely rare in the larynx and should be distinguished from squamous cell carcinoma. therefore, it must be known by clinicians, pathologists and oncologists. in this case report, we discuss its etiopathogeny, its epidemiological, clinical, pathological and therapeutic aspects, and its outcome. | 2017 | 29204101 |
| the role of the early social environment on epstein barr virus infection: a prospective observational design using the millennium cohort study. | epstein-barr virus (ebv) is a highly prevalent herpesvirus linked to infectious mononucleosis and several malignancies. this paper aims to study the association between children's early life social environment at 9 months and ebv infection at 3 years of age. | 2017 | 29202893 |
| epstein-barr virus induces adhesion receptor cd226 (dnam-1) expression during primary b-cell transformation into lymphoblastoid cell lines. | epstein-barr virus (ebv), an oncogenic herpesvirus, infects and transforms primary b cells into immortal lymphoblastoid cell lines (lcls), providing a model for ebv-mediated tumorigenesis. ebv transformation stimulates robust homotypic aggregation, indicating that ebv induces molecules that mediate cell-cell adhesion. we report that ebv potently induced expression of the adhesion molecule cd226, which is not normally expressed on b cells. we found that early after infection of primary b cells, e ... | 2017 | 29202043 |
| epstein-barr virus and cytomegalovirus induced acute hepatitis in young female patient. | acute hepatitis is a disorder that goes with liver cell necrosis and liver inflammation. among the causes of acute hepatitis, the most common reasons are viral hepatitis. about 95% of the acute hepatitis generate because of hepatotropic viruses. epstein-barr virus (ebv) and cytomegalovirus (cmv) are from the family of herpes viruses and rare causes of acute hepatitis. in this case report, acute hepatitis due to ebv and cmv coinfection will be described. | 2017 | 29201691 |
| a rare case of chronic active epstein-barr virus (ebv) infection accompanied by the infiltration of ebv-infected cd8+ t cells into the muscle. | we describe a rare case of chronic active epstein-barr virus (caebv) infection, with infiltration of the skeletal muscle. a 19-year-old woman with swollen cervical lymph nodes and a fever was referred to our hospital. swelling of the trapezium muscle and elevation of creatinine kinase level were observed. biopsy results of the brachialis muscle revealed infiltration of epstein-barr virus (ebv)-encoded rna-positive cd8 t lymphocytes. the ebv virus load in the peripheral blood was high, and ebv mo ... | 2017 | 29200172 |
| clinical challenges: identification of patients with novel primary immunodeficiency syndromes. | novel primary immunodeficiency disorders are being identified with next generation sequencing technologies. we describe 1 patient with cytotoxic t-lymphocyte-associated protein 4 (ctla-4) haploinsufficiency who had recurrent enhancing brain lesions, nodular pulmonary infiltrates, hepatosplenomegaly, immune cytopenias, as well as progressive hypogammaglobulinemia and lymphopenia. we describe a second patient with activated p110δ syndrome (apds)/p110δ activating mutation causing senescent t cells, ... | 2017 | 29200144 |
| peroxiredoxin-2 and zinc-alpha-2-glycoprotein as potentially combined novel salivary biomarkers for early detection of oral squamous cell carcinoma using proteomic approaches. | no effective screening method is available for oral squamous cell carcinoma (oscc) that is recognized to influence by environmental factors as well as human papillomavirus (hpv) and epstein-barr virus (ebv). therefore, we sought to identify salivary biomarkers for screening of oscc with or without hpv and/or ebv infection. saliva, lesion and oral exfoliated cells were collected from oscc patients and cancer-free controls (cfcs) and grouped depending on their hpv- and ebv-infection status. saliva ... | 2018 | 29199150 |
| comparison of abbott architect®, siemens immulite®, and diasorin liaison® for determination of epstein-barr virus serological diagnosis. | this study compared the performance of 3 automated immunoassays, architect® (abbott), immulite® (siemens) and liaison® (diasorin), for epstein-barr virus (ebv) serology. ninety-one serum samples collected in amiens university hospital were analyzed for the presence of viral capsid antigen (vca) igg and igm and epstein-barr nuclear antigen (ebna) igg. the agreement between the 3 assays was calculated for each marker individually and for determination of the ebv profile, based on interpretation of ... | 2018 | 29198371 |
| ebv+ hhv-8+ multicentric castleman disease with plasmablastic aggregates in an hiv+ man: an evolving clinicopathologic entity. | we report a case of ebv+ and hhv-8+ multicentric castleman disease with plasmablastic aggregates in an hiv-positive individual. a 41-year-old man presented in early 2015 with fevers, sweats, weight loss, intractable itching, and on subsequent testing was found to be hiv positive. investigations showed cervical lymphadenopathy and splenomegaly. he was treated for hiv and his symptoms resolved. his symptoms recurred in january 2016, and a provisional diagnosis of multicentric castleman disease was ... | 2017 | 29198143 |
| potential cancer chemopreventive and anticancer constituents from the fruits of ficus hispida l.f. (moraceae). | ficus hispida l.f. (moraceae) has been used as alternative for traditional medicine in the treatment of various ailments including cancer-cure. the aim of this study was to evaluate the cancer chemopreventive and anticancer activities of crude extracts of f. hispida, with the objective to screen the inhibition of epstein-barr virus early antigen, and cytotoxic active components, and provide foundation for potential applications of this promising medical plant. | 2018 | 29197545 |
| methotrexate-associated lymphoproliferative disease with multiple pulmonary nodules in a patient with rheumatoid arthritis. | a 62-year-old woman with rheumatoid arthritis and secondary sjögren's syndrome took methotrexate (mtx) 5 mg three times a week regularly but gradually developed an intermittent fever, oral ulcers and productive cough with mucopurulent sputum for about 2 weeks. image study found multiple nodular lesions and lymphadenopathies in bilateral lungs. empirical antibiotics for 1 week failed to alleviate the fever. a transbronchial biopsy in the right fourth bronchus showed infiltration of abnormally enl ... | 2017 | 29196307 |
| characterization of the ebv-induced persistent dna damage response. | epstein-barr virus (ebv) is an oncogenic herpesvirus that is ubiquitous in the human population. early after ebv infection in vitro, primary human b cells undergo a transient period of hyper-proliferation, which results in replicative stress and dna damage, activation of the dna damage response (ddr) pathway and, ultimately, senescence. in this study, we investigated ddr-mediated senescence in early arrested ebv-infected b cells and characterized the establishment of persistent dna damage foci. ... | 2017 | 29194355 |
| clinical significance of plasma epstein-barr virus dna in pulmonary lymphoepithelioma-like carcinoma (lelc) patients. | 2017 | 29191777 | |
| pretreatment epstein-barr virus dna in whole blood is a prognostic marker in peripheral t-cell lymphoma. | because there are few studies regarding the clinical impact of circulating ebv-dna in peripheral t-cell lymphomas (ptcls), we tried to evaluate the role of ebv-dna in whole blood as a prognostic factor for ptcl. we retrospectively reviewed 110 ptcl patients with median age of 63 (20-94) years. forty-seven patients (42.7%) showed positive results for ebv-dna, and these patients also had stage iii/iv disease, elevated lactic dehydrogenase, and low albumin level (p = 0.007, p = 0.004, p = 0.002, re ... | 2017 | 29190917 |
| in response to: smit d, meyer d, maritz j, et al. "polymerase chain reaction and goldmann-witmer coefficient to examine the role of epstein-barr virus in uveitis". | 2017 | 29190161 | |
| epstein-barr virus clonality and plasmacytosis in a patient with atypical angioimmunoblastic t cell lymphoma. | 2017 | 29189897 | |
| viral dnaemia and immune suppression in pediatric sepsis. | demonstrate that dna viremia is common in pediatric sepsis and quantitate its associations with host immune function and secondary infection risk. | 2018 | 29189638 |
| infusions of epstein-barr virus-specific cytotoxic t lymphocytes as post-remission therapy in high-risk post-transplant lymphoproliferative disorder patients: report of two cases. | conventional therapeutic approaches to post-transplant lymphoproliferative disorder (ptld) occurring after solid-organ transplantation have shown only limited success in achieving durable response. key factors driving the pathogenesis of ptld include epstein-barr virus (ebv) reactivation and impaired immune surveillance due to prolonged immune suppression. thus, ebv-specific cytotoxic t lymphocytes (ebv-ctls) have emerged as an alternative therapeutic approach for the treatment of ebv-associated ... | 2017 | 29188583 |
| [symmetrical lesions of the cerebral peduncles and internal capsules on mri in a patient with extranodal nk/t cell lymphoma]. | a 72-year-old man was admitted to our hospital because of subacute progressive consciousness disturbance. flair images showed diffuse high intensity areas in the bilateral thalamus, basal ganglia, and white matter. chest ct revealed a mass in the right lung. the patient was diagnosed with extranodal natural killer/t cell lymphoma (enkl) according to the results of a biopsy of the right pulmonary mass. the flair images showed diffuse white matter lesions, without a mass such as lymphomatosis cere ... | 2017 | 29187687 |
| relationship between ppp1r15a gene polymorphism (rs611251) and epstein-barr virus-associated tumors. | protein phosphatase 1, regulatory subunit 15a (ppp1r15a), also known as growth arrest and dna damage-inducible protein gadd34, plays a vital role in promoting cell death and the unfolded protein response (upr). in order to explore whether the snp (rs611251) of ppp1r15a gene has a role in different types of epstein-barr virus (ebv) - associated tumors, we detected the ppp1r15a gene rs611251 polymorphism in 195 cases of ebv positive tumors (93 lymphomas, 48 gastric carcinomas, 54 nasopharyngeal ca ... | 2017 | 29186961 |