Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| the suceptibility of malayan anophelines to plasmodium cynomolgi bastianellii. | 1963 | 14274297 | |
| transmission of a new strain of plasmodium cynomolgi to man. | 1965 | 14259487 | |
| the localization of infective pre-erythrocytic forms of plasmodium cynomolgi. | 1964 | 14128583 | |
| the activity of a repository form of 4,6-diamino-1(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine against infections with plasmodium cynomolgi. | 1963 | 14044759 | |
| malaria in man. infection by plasmodium vivax and the b strain of plasmodium cynomolgi. | 1963 | 13927675 | |
| clinical and physiological responses in sporozoite-induced b strain plasmodium cynomolgi and plasmodium vivax infections in normal volunteers. | 1962 | 13927674 | |
| effect of certain drugs on exoerythrocytic parasites of plasmodium cynomolgi. | 1962 | 13891113 | |
| man to man transfer of two strains of plasmodium cynomolgi by mosquito bite. | 1962 | 13880974 | |
| blood loss and replacement in plasmodial infections. iii. plasmodium cynomolgi, plasmodium gonderi and plasmodium knowlesi in macaca mulatta mulatta, the rhesus monkey. | 1960 | 13847844 | |
| vivax-type malaria parasite of macaques transmissible to man. | transmission of plasmodium cynomolgi bastianellii from rhesus monkeys to two human subjects by anopheles freeborni and the occurrence of attacks of malaria in two other laboratory workers not exposed to human malaria suggests the existence of an animal reservoir of infection complicating malaria control and eradication. | 1960 | 13821129 |
| the transmission of plasmodium cynomolgi to man. | 1961 | 13748031 | |
| the exoerythrocytic cycle of plasmodium cynomolgi and p. cynomolgi bastianellii in the rhesus monkey. | 1960 | 13697716 | |
| transmission of the m strain of plasmodium cynomolgi to man. | 1961 | 13694174 | |
| partial inhibitory effect of plistophora culicis on the sporogonic cycle of plasmodium cynomolgi in anopheles stephensi. | 1958 | 13504228 | |
| additional notes on the tissue stages of plasmodium cynomolgi. | 1957 | 13443015 | |
| absence of cross-immunity between plasmodium cynomolgi and plasmodium gonderi. | 1955 | 13306283 | |
| [pathological-immunity relations between parasite and host in macacus rhesus inoculated with blood infected with plasmodium cynomolgi, later splenectomized and repeatedly reinfected with homologous strain]. | 1954 | 13204670 | |
| further notes on the tissue stages of plasmodium cynomolgi. | 1954 | 13157157 | |
| the development of exoerythrocytic stages of plasmodium inui shortti in new world monkeys. | attempts are being made to adapt old world monkey malarial parasites to new world monkeys for vaccine and molecular studies. several of these (plasmodium cynomolgi berok, plasmodium fragile, and plasmodium knowlesi) grow readily but have failed to produce infective gametocytes. plasmodium gonderi and plasmodium fieldi develop in the liver after sporozoite inoculation but have failed to establish infection in the erythrocyte. anopheles dirus mosquitoes infected with plasmodium inui shortti by fee ... | 2003 | 12880277 |
| replication fork-stimulated eif-4a from plasmodium cynomolgi unwinds dna in the 3' to 5' direction and is inhibited by dna-interacting compounds. | plasmodium cynomolgi dead-box dna helicase 45 (pcddh45) is an atp-dependent dna-unwinding enzyme with intrinsic dna-dependent atpase activity and is highly homologous to eif-4a. in this study, we have further characterized and tested the effect of various dna-interacting compounds on the dna-unwinding activity of pcddh45. the results show that pcddh45 translocates in the 3' to 5' direction along the bound strand, a replication fork-like structure of the substrate stimulates its dna-unwinding act ... | 2003 | 12745261 |
| blood schizontocidal activity of wr 238605 (tafenoquine) against plasmodium cynomolgi and plasmodium fragile infections in rhesus monkeys. | a new 8-aminoquinoline antimalarial wr 238605 (tafenoquine), developed initially as a primaquine alternative for prevention of plasmodium vivax relapses was evaluated for blood schizontocidal activity against two simian malaria infections namely plasmodium cynomolgi b and plasmodium fragile in rhesus monkeys. treatment with wr 238605 at a dose of 3.16 mg(base)/kg/day x 7 days cured established trophozoite induced infections in monkeys with both these parasites. the lower dose of 1.00 mg/kg/day c ... | 2003 | 12711101 |
| [practicability of ifat using plasmodium cynomolgi and plasmodium falciparum antigens in different malarious areas]. | to compare the practicability of ifat in different malarious areas using plasmodium cynomolgi(p.c.) and plasmodium falciparum(p.f.) antigens. | 2000 | 12567477 |
| cytokine responses during acute simian plasmodium cynomolgi and plasmodium knowlesi infections. | experimental infection of non-human primates with simian malaria parasites offers a controlled system to study malarial immunity. plasmodium cynomolgi (p. vivax-like) and p. knowlesi (p. falciparum-like) infections in the rhesus monkey were used as a model to test the hypothesis that initial acute infection stimulates type 1/pro-inflammatory cytokine expression followed by a gradual type 2/anti-inflammatory response upon re-infection. this study analyzed cytokine gene expression (interleukin-12, ... | 2002 | 12518848 |
| isolation and characterization of an eif-4a homologue from plasmodium cynomolgi. | 2002 | 12387853 | |
| immunogenicity and protective efficacy of three dna vaccines encoding pre-erythrocytic- and erythrocytic-stage antigens of plasmodium cynomolgi in rhesus monkeys. | although several malaria vaccine candidate antigens have been identified, the most suitable methods for their delivery are still being investigated. in this regard, direct immunization with dna encoding these vaccine target antigens is an attractive alternative. here, we have investigated the immune responses to dna immunization with three major vaccine target antigens: the apical membrane antigen-1 and the 19-kda c-terminal fragment of merozoite surface protein-1 from the erythrocytic stage, an ... | 2002 | 12208604 |
| merozoite surface protein-9 of plasmodium vivax and related simian malaria parasites is orthologous to p101/abra of p. falciparum. | plasmodium vivax merozoite surface protein-9 (pvmsp-9) is characterized here along with orthologues from the related simian malarias plasmodium cynomolgi and plasmodium knowlesi. we show that although the corresponding msp-9 proteins do not have acidic-basic repeated amino acid (aa) motifs, they are related to the plasmodium falciparum acidic-basic repeat antigen (abra) also known as p101. recognition of this new interspecies plasmodium msp family stems from the prior identification of related m ... | 2002 | 11849704 |
| a class of potent antimalarials and their specific accumulation in infected erythrocytes. | during asexual development within erythrocytes, malaria parasites synthesize considerable amounts of membrane. this activity provides an attractive target for chemotherapy because it is absent from mature erythrocytes. we found that compounds that inhibit phosphatidylcholine biosynthesis de novo from choline were potent antimalarial drugs. the lead compound, g25, potently inhibited in vitro growth of the human malaria parasites plasmodium falciparum and p. vivax and was 1000-fold less toxic to m ... | 2002 | 11847346 |
| demonstration of a persisting exo-erythrocytic cycle in plasmodium cynomolgi and its bearing on the production of relapses. 1948. | 2000 | 11196492 | |
| azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys. | the spectrum of antimalarial activity of the new macrolide antibiotic azithromycin was evaluated against blood- and sporozoite-induced infections with a chloroquine-resistant strain of plasmodium yoelii nigeriensis (n-67) in swiss mice and with simian parasite plasmodium cynomolgi b in rhesus monkeys. against experimental rodent malaria, a 70 mg/kg/day dose showed curative blood-schizontocidal activity in a four-dose regimen administered orally from day 0 to day 3 or from day 2 to day 5 to mice ... | 2000 | 10631075 |
| plasmodium cynomolgi: transfection of blood-stage parasites using heterologous dna constructs. | 1999 | 10464040 | |
| the crystal structure of c-terminal merozoite surface protein 1 at 1.8 a resolution, a highly protective malaria vaccine candidate. | the c-terminal proteolytic processing product of merozoite surface protein 1 (msp1) appears essential for successful erythrocyte invasion by the malarial parasite, plasmodium. we have determined the crystal structure at 1.8 a resolution of a soluble baculovirus-recombinant form of the protein from p. cynomolgi, which confers excellent protective efficacy in primate vaccination trials. the structure comprises two egf-like domains, and sequence comparisons strongly suggest that the same conformati ... | 1999 | 10230398 |
| studies on infections with the berok strain of plasmodium cynomolgi in monkeys and mosquitoes. | infections with the berok strain of plasmodium cynomolgi were induced in macaca mulatta, macaca fascicularis, macaca nemestrina, aotus lemurinus griseimembra, aotus azarae boliviensis, and saimiri boliviensis monkeys. transmission was obtained with sporozoites developing in anopheles peditaeniatus, anopheles maculatus, anopheles quadrimaculatus, anopheles culicifacies, and anopheles dirus mosquitoes. this strain of p. cynomolgi offers significant potential for a number of experimental studies. t ... | 1999 | 10219307 |
| plasmodium vivax, p. cynomolgi, and p. knowlesi: identification of homologue proteins associated with the surface of merozoites. | we have identified a plasmodium vivax merozoite surface protein (msp) that migrates on sds-polyacrylamide gels at a mr of about 185 kda. this protein was recognized by a p. vivax monoclonal antibody (mab) that localizes the protein by immunofluorescence to the surface of merozoites and also immunoprecipitates this protein from np-40 detergent extracts of [35s]methionine metabolically radiolabeled p. vivax schizonts. the p. vivax msp does not become biosynthetically radiolabeled with [3h]glucoami ... | 1999 | 10072326 |
| rna helicase-related genes of plasmodium falciparum and plasmodium cynomolgi. | rna helicases play many essential roles including cell development and growth. using degenerate oligonucleotide primers designed to amplify dna fragments flanked by the highly conserved helicase motifs vldead and yihrig and genomic dnas from the malarial parasites as a template, we have cloned two putative rna helicase genes (546 and 540 bp) from p. falciparum and one gene (546 bp) from p. cynomologi. southern blot analysis revealed that these could be multiple and single-copy genes in p. falcip ... | 1999 | 10049705 |
| linkage of a gene causing malaria refractoriness to diphenol oxidase-a2 on chromosome 3 of anopheles gambiae. | an inbred line of the african malaria vector anopheles gambiae is refractory to development of malaria parasites. it is homozygous for a 4.3-kb sal i restriction fragment at the dox-a2 locus, whereas the parent population is polymorphic at this locus, and a susceptible line is homozygous for an alternate 3.85-kb fragment. the dox-a2 locus is located in the middle of chromosome 3r, in division 33b, and is tightly linked to a cluster of genes including dopa decarboxylase that are involved in the p ... | 1999 | 9988317 |
| high-level expression of plasmodium vivax apical membrane antigen 1 (ama-1) in pichia pastoris: strong immunogenicity in macaca mulatta immunized with p. vivax ama-1 and adjuvant sbas2. | the apical membrane antigen 1 (ama-1) family is a promising family of malaria blood-stage vaccine candidates that have induced protection in rodent and nonhuman primate models of malaria. correct conformation of the protein appears to be essential for the induction of parasite-inhibitory responses, and these responses appear to be primarily antibody mediated. here we describe for the first time high-level secreted expression (over 50 mg/liter) of the plasmodium vivax ama-1 (pv66/ama-1) ectodomai ... | 1999 | 9864194 |
| plasmodium inui is not closely related to other quartan plasmodium species. | plasmodium inui (halberstaedter and von prowazek, 1907), a malarial parasite of old world monkeys that occurs in isolated pockets throughout the celebes, indonesia, malaysia, and the philippines, has traditionally been considered to be related more closely to plasmodium malariae of humans (and its primate counterpart plasmodium brasilianum), than to other primate plasmodium species. this inference was made in part because of the similarities in the periodicities or duration of the asexual cycle ... | 1998 | 9576499 |
| baculovirus merozoite surface protein 1 c-terminal recombinant antigens are highly protective in a natural primate model for human plasmodium vivax malaria. | a successful anti-blood stage malaria vaccine trial based on a leading vaccine candidate, the major merozoite surface antigen-1 (msp1), is reported here. the trial was based on plasmodium cynomolgi, which is a primate malaria parasite which is highly analogous to the human parasite plasmodium vivax, in its natural host, the toque monkey, macaca sinica. two recombinant baculovirus-expressed p. cynomolgi msp1 proteins, which are analogous to the 42- and 19-kda c-terminal fragments of p. falciparum ... | 1998 | 9529073 |
| phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate. | the phage-displayed peptide cgrvclrc (c15) has been isolated from a random library by affinity screening with the d14-3 monoclonal antibody, which was raised to the 42 kda c-terminal fragment of the major merozoite surface protein 1 of plasmodium vivax (pv42). in order to investigate the use of such mimotopes as possible vaccine components, we studied the antibody response in biozzi mice immunized with c15. high titers of antibodies cross-reacting with pv42 were generated and the ic50 of all imm ... | 1998 | 9504719 |
| cloning and sequence analysis of the thrombospondin-related adhesive protein (trap) gene of plasmodium cynomolgi bastianelli. | 1997 | 9497063 | |
| characterization of c-terminal merozoite surface protein-1 baculovirus recombinant proteins from plasmodium vivax and plasmodium cynomolgi as recognized by the natural anti-parasite immune response. | 1997 | 9364976 | |
| cloning and sequence analysis of a gene encoding an erythrocyte binding protein from plasmodium cynomolgi. | 1997 | 9364974 | |
| a genetic study of a melanization response to sephadex beads in plasmodium-refractory and -susceptible strains of anopheles gambiae. | a previously selected plasmodium-refractory strain of anopheles gambiae melanotically encapsulates many species of plasmodium. genetic studies of this strain have shown that this refractory phenotype is controlled by a limited number of genes, and the existence of two such genes, pif-b and pif-c, has been demonstrated. further work to determine the molecular basis for this mode of refractoriness led to the discovery that the host-parasite interaction is mimicked by the mosquito's response to car ... | 1997 | 9158056 |
| quantitative trait loci for refractoriness of anopheles gambiae to plasmodium cynomolgi b. | the severity of the malaria pandemic in the tropics is aggravated by the ongoing spread of parasite resistance to antimalarial drugs and mosquito resistance to insecticides. a strain of anopheles gambiae, normally a major vector for human malaria in africa, can encapsulate and kill the malaria parasites within a melanin-rich capsule in the mosquito midgut. genetic mapping revealed one major and two minor quantitative trait loci (qtls) for this encapsulation reaction. understanding such antiparas ... | 1997 | 9103203 |
| sterile protection of monkeys against malaria after administration of interleukin-12. | an estimated 300-500 million new infections and 1.5-2.7 million deaths attributed to malaria occur annually in the developing world, and every year tens of millions of travelers from countries where malaria is not transmitted visit countries with malaria. because the parasites that cause malaria have developed resistance to many antimalarial drugs, new methods for prevention are required. intraperitoneal injection into mice of one dose of 150 ng (approximately 7.5 micrograms per kg body weight) ... | 1997 | 8986746 |
| in-vitro cultivation of exoerythrocytic stages of plasmodium cynomolgi in hepatocytes of macaca radiata. | hepatocytes from bonet monkey (macaca radiata) obtained by perfusion of a liver biopsy were infected in-vitro with plasmodium cynomolgi bastianellii sporozoites raised in anopheles stephensi. the development of exoerythrocytic (ee) stages was seen under phase contrast microscope and by giemsa staining. multinucleated ee-stages were seen in the cultured hepatocytes on day 7-8 post-sporozoite inoculation. | 1996 | 8952170 |
| a shared genetic mechanism for melanotic encapsulation of cm-sephadex beads and a malaria parasite, plasmodium cynomolgi b, in the mosquito, anopheles gambiae. | a plasmodium-refractory strain of anopheles gambiae that melanizes ookinetes and intrathoracically inoculated cm-sephadex beads was mated to a plasmodium-susceptible strain that does not melanize the parasite or the beads. the f1 progeny were then backcrossed to the susceptible strain. backcross progeny were given a blood meal containing infective plasmodium cynomolgi b, and the parasites were allowed to develop for 6-7 days, at which time the infected mosquitoes were injected with cm-sephadex b ... | 1996 | 8948327 |
| the plasmodium cynomolgi merozoite surface protein 1 c-terminal sequence and its homologies with other plasmodium species. | 1995 | 8719250 | |
| gametocytocidal activity of alpha/beta arteether by the oral route of administration. | arteether (alpha/beta) (a mixture of alpha and beta enantioners) has been reported to possess gametocytocidal activity against plasmodium cynomolgi b when the drug is given by the intramuscular route, but it would be preferable to use oral route therapy for gametocyte carriers. this is a report of a study of the gametocytocidal action of arteether administered by the oral route. the results indicate high levels of activity at 10 mg/kg in a single dose or in two divided doses when given orally. | 1996 | 8686787 |
| histochemical changes in host tissues from plasmodium cynomolgi b infected rhesus monkey (macaca mulatta). | plasmodium cynomolgi b has been used to infect the rhesus monkey to study the histochemical changes (lipid infiltration, glycogen, protein, dna and rna) in liver, kidney and spleen during early (exoerythrocytic) and late (chronic) stages of malarial infection. infected liver showed significant lipid infiltration during exoerythrocytic and erythrocytic (acute phase) stage of infection. kidney showed lipid deposition during acute phase of infection while spleen sections were negative for lipid dep ... | 1996 | 8641716 |
| poly iclc inhibits plasmodium cynomolgi b malaria infection in rhesus monkeys. | prophylatic treatment with a single dose of 1.0 or 2.0 mg/kg (body weight) of polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (poly iclc), a potent interferon (ifn) inducer and immune enhancer, 18 h before intravenous inoculation of sporozoites (1.04 x 10(5)-0.70 x 10(6) sporozoites) of plasmodium cynomolgi b in the rhesus monkey, completely abolished the infectivity of sporozoites. the inhibitory effect of poly iclc is dose dependent in monkeys infected wit ... | 1996 | 8640451 |
| sodium beta-artelinate--a new potential gametocytocide. | the water-soluble artemisinin analogue sodium beta-artelinate, a fast-acting blood schizontocide, was evaluated for gametocytocidal action against simian malaria plasmodium cynomolgi b, and a single dose of the compound has been found to be an effective gametocytocide by both oral and intravenous routes. the compound was able to sterilize the circulating gametocytes in rhesus monkey, resulting in loss of mosquito infectivity and oocyst development in the anopheles stephensi. however, no sporonto ... | 1996 | 8631376 |
| sequence analysis of apical membrane antigen 1 (ama-1) of plasmodium cynomolgi bastianelli. | 1995 | 8577338 | |
| hydrolytic enzymes of rhesus placenta during plasmodium cynomolgi infection: ultrastructural and biochemical studies. | placenta in monkey demonstrated altered pathophysiology after p cynomolgi infection. the electronmicroscopic observations showed slight complete focal necrosis of the placental tissue, besides alterations in total protein, phosphatases and proteinases. these changes in cellular constituents of placenta during malaria infection may be responsible for malfunctioning of the organ and in turn, abnormal development of foetus. | 1993 | 8500817 |
| association of two esterase genes, a chromosomal inversion, and susceptibility to plasmodium cynomolgi in the african malaria vector anopheles gambiae. | the ability of a selected strain of the malaria vector anopheles gambiae to encapsulate the early oocysts of the malaria parasite plasmodium cynomolgi b has previously been shown to be genetically linked to specific esterase phenotypes. this association between plasmodium susceptibility and esterase phenotype is found in the an. gambiae g3 strain from which the plasmodium-refractory and -susceptible mosquito strains were derived. genetic crosses had suggested that the esterase phenotypes reflect ... | 1993 | 8372956 |
| causal prophylactic and radical curative activity of wr182393 (a guanylhydrazone) against plasmodium cynomolgi in macaca mulatta. | primaquine is the only currently available drug effective against persistent tissue stages of relapsing malaria in humans. causal prophylactic and radical curative properties of wr182393 (a guanylhydrazone) were investigated as part of an effort to evaluate alternatives to primaquine in the rhesus monkey (macaca mulatta)/plasmodium cynomolgi test model. the drug was suspended in dimethylsulfoxide for intramuscular (im) injection. a pilot study indicated causal prophylactic activity in a regimen ... | 1993 | 8214277 |
| proguanil plus sulfamethoxazole is not causally prophylactic in the macaca mulatta--plasmodium cynomolgi model. | new drugs for causal prophylaxis of malaria are needed. a proguanil/sulfamethoxazole combination was investigated using a rhesus monkey model (macaca mulatta infected with plasmodium cynomolgi) to determine whether causal prophylaxis could be achieved. when a five-day regimen of proguanil (40 mg/kg/day) combined with sulfamethoxazole (100 mg/kg/day) was used, infection of all animals (6 of 6) was observed, with an extended prepatent period (median 40 days). two control animals became infected on ... | 1994 | 8203715 |
| role of fatty infiltration during malaria in rhesus monkey. | p. cynomolgi b-rhesus monkey model of malarial infection has been used to study lipid infiltration in host tissues in early (exoerythrocytic) and late (chronic) stages of malaria infection. histochemically we could demonstrate significant infiltration of neutral & total lipids in liver during the exoerythrocytic stage and in liver and kidney in the erythrocytic stage. the parasite used in the study closely resembles the human parasite p. vivax. it has a defined prepatent period, can be cyclicall ... | 1994 | 8196503 |
| [studies on residual antimalarial activity of tripynadine in mice and monkeys]. | this paper reports the experiments in which tripynadine free base at a dose 4.5 times that of ed50 was given to mice by intragastric administration. on the 20th day following the administration the mice were inoculated with 1 x 10(7) rbc infected with plasmodium berghei anka strain. the infection rate was zero, implying that all mice had acquired protection. although the residual activity time of tripynadine phosphate was longer than that of tripynadine free base or piperaquine phosphate, but tr ... | 1993 | 8168241 |
| [studies on the establishment of malarial animal model of short-term relapse. iii. combined therapy with pyronaridine-artemether-chloroquine for parasitemia clearance]. | to establish a plasmodium cynomolgi-monkey model of short-term relapse, different antimalarials have been used to inhibit recrudescence so as to elude the confusion between the two different onsets. when a single dose of effective schizonticides pyronaridine, artemether or chloroquine was administered, recrudesence readily occurred. this paper reports the results of the combined therapy with the above three drugs. seven rhesus monkeys from guangxi autonomous region infected with plasmodium cynom ... | 1993 | 8168239 |
| evaluation of wr250417 (a proguanil analog) for causal prophylactic activity in the plasmodium cynomolgi-macaca mulatta model. | the plasmodium cynomolgi-macaca mulatta model has been used to test the antimalarial activity of new drugs for both radical cure and casual prophylaxis. the proguanil analog wr250417 (also known as ps-15) was evaluated for causal prophylactic activity in rhesus monkeys infected with p. cynomolgi bastianelli. four monkeys were orally dosed with 40 mg/kg/day of wr250417 over three days (-1, 0, and +1). sporozoite-induced infection of p. cynomolgi was initiated on day 0 with 1 x 10(6) sporozoites t ... | 1994 | 8116810 |
| [progress on the study of the distribution of plasmodium cynomolgi in the world]. | 1994 | 8082460 | |
| [studies on the establishment of malarial animal model of short-term relapse. iv. short-term relapse in rhesus monkeys infected with sporozoites of plasmodium cynomolgi]. | the present paper reports that the short-term relapse could be artificially made by the application of the experimental method, and thus we established the monkey model of the short-term relapse. according to the experimental design, when the parasitemia was detected in rhesus monkeys infected with sporozoites of plasmodium cynomolgi, a combined therapy of pyronaridine 6 mg/kg body weight, artemether 10 mg/kg and chloroquine 20 mg/kg once daily for 3 days was carried out to clear the erythrocyti ... | 1993 | 8082260 |
| removal of leucocytes from plasmodium vivax-infected blood. | 1994 | 8067817 | |
| the small ribosomal subunit rna isoforms in plasmodium cynomolgi. | we report the isolation, characterization and analysis of the small subunit rrna genes in plasmodium cynomolgi (ceylon). as in other plasmodium species, these genes are present in low copy number, are unlinked and form two types that are distinct in sequence and are expressed stage specifically. the asexually expressed (type a) genes are present in four copies in the ceylon- and in five copies in the berok-strain. surprisingly, the sexually expressed (type b) gene is present in a single copy. th ... | 1994 | 8005440 |
| immunologic characterization of plasmodium vivax antigens using plasmodium cynomolgi liver stage-primed immune sera. | we have shown in a previous study that immunization of a rhesus monkey (macaca mulatta) with inactivated liver stages of the simian malaria parasite plasmodium cynomolgi (b strain) produced high antibody titers against sporozoites, liver stages, and blood stages of p. cynomolgi. in the present study, we demonstrate that these anti-p. cynomolgi immune sera recognized p. vivax (salvador i) antigens. in an indirect immunofluorescence assay, both postimmunization and postchallenge sera reacted with ... | 1994 | 7943558 |
| use of the rhesus monkey as an experimental model to test the degree of efficacy of an anti-sporozoite peptide malaria vaccine candidate combined with copolymer-based adjuvants. | humoral response against sporozoites is not effective in protecting individuals from getting malaria. reduction in the infectivity of sporozoites has not been quantified for most anti-sporozoite vaccines tested. quantification requires animal models providing predictable prepatent periods, e.g., time elapsed between sporozoite inoculation and detection of parasitemia, to be used as an indicator of activity against sporozoites. a delay in prepatent period from vaccinated animals would therefore r ... | 1995 | 7741171 |
| evolutionary relatedness of some primate models of plasmodium. | primate--and, specifically, monkey--malaria infections are commonly used for understanding the pathology of and immune response to the human disease because they are thought to resemble most closely the host-parasite relationship found in humans. plasmodium cynomolgi is used extensively as a model for the human parasite, p. vivax, and p. knowlesi is used primarily as a model for the development of erythrocytic-stage vaccines. both of these simian parasites can naturally infect man, resulting in ... | 1993 | 7689135 |
| cultivation in vitro of the vivax-type malaria parasite plasmodium cynomolgi. | the vivax-type simian malaria parasite plasmodium cynomologi was cultured in vitro by both the candle jar method and the continuous flow technique, with rhesus monkey erythrocytes and rpmi 1640 medium supplemented with hepes buffer and human serum. after 6 weeks in culture, the growth of the parasite had permitted a 5 x 10(6) cumulative dilution of the original inoculum. cultured parasites remained infective to rhesus monkeys and exhibited a reversible decrease in the ameboid behavior of their t ... | 1981 | 7233207 |
| comparative efficacies of quinine and chloroquine as companions to primaquine in a curative drug regimen. | a comparison has been made of the capacities of chloroquine and quinine to serve as companions to primaquine in curing established infections with sporozoites of the m or b strains of plasmodium cynomolgi in rhesus monkeys. the results indicated that chloroquine was slightly but consistently more effective than quinine in this role. this finding provides support for use of chloroquine as the companion blood schizonticide in the current experimental animal-based search for improved tissue schizon ... | 1981 | 7212167 |
| synthesis and antimalarial activity of 8-[(1-alkyl-4-aminobutyl)amino]-6-methoxy-4-methylquinolines. | three analogues of the causal prophylactic antimalarial primaquine were prepared and their antimalarial activity was evaluated. 8-[(1-ethyl-4-aminobutyl)amino]-6-methoxy-4-methylquinoline (2a) demonstrated activity against plasmodium berghei in mice at 20 mg/kg, with all animals cured at 320 mg/kg, and is without toxicity at 640 mg/kg. it also possessed outstanding causal prophylactic activity against plasmodium cynomolgi in rhesus monkeys at very low dosages. | 1981 | 7205891 |
| presbytis entellus and macaca radiata as new hosts for experimental plasmodium cynomolgi bastianellii infection. | 1982 | 7174004 | |
| response to plasmodium cynomolgi infection in a protein deficient host. | 1982 | 7152561 | |
| antimalarials. 14. 5-(aryloxy)-4-methylprimaquine analogues. a highly effective series of blood and tissue schizonticidal agents. | a series of five 5-(aryloxy)-4-methylprimaquine analogues has been prepared and evaluated for antimalarial activity. the compounds were tested for suppressive activity against plasmodium berghei in mice and for radical curative activity against plasmodium cynomolgi in the rhesus monkey. the compounds were not only significantly superior to primaquine as radical curative agents but also were suprisingly highly effective as suppressive agents. | 1982 | 7131488 |
| plasmodium cynomolgi infections in the rhesus monkey. | 1982 | 7081552 | |
| observations on early and late post-sporozoite tissue stages in primate malaria. i. discovery of a new latent form of plasmodium cynomolgi (the hypnozoite), and failure to detect hepatic forms within the first 24 hours after infection. | previous work in this laboratory has demonstrated the ability of the immunofluorescence technique to detect pre-erythrocytic stages of the primate malaria parasite, plasmodium cynomolgi bastianellii, in hepatic tissue obtained as early as 48 hours after sporozoite inoculation. in an attempt to visualize still earlier post-sporozoite stages, hepatic tissue obtained from a rhesus monkey infected with 12,000,000 sporozoites was examined at 2, 12, 24, and 48 hours after inoculation, employing antise ... | 1982 | 7058977 |
| observations on early and late post-sporozoite tissue stages in primate malaria. ii. the hypnozoite of plasmodium cynomolgi bastianellii from 3 to 105 days after infection, and detection of 36- to 40-hour pre-erythrocytic forms. | confirmation of the existence of a persistent, uninucleate, dormant pre-erythrocytic stage, the hypnozoite, of the relapsing simian malaria parasite, plasmodium cynomolgi bastianellii, has been obtained by means of experiments involving the intravenous injection into susceptible monkeys of 48 to 85 x 10(6) sporozoites derived from mosquitoes of a different species and source than employed previously. the development of these hypnozoites was traced from 3 days until 105 days after sporozoite inoc ... | 1982 | 7041663 |
| [two accidental human infections by plasmodium cynomolgi bastianellii. a clinical and serological study]. | 1980 | 7016051 | |
| the 48-hour exoerythrocytic stage of plasmodium cynomolgi bastianellii. | detection and specific identification of the 48-hour exoerythrocytic stage of the primate malaria parasite, plasmodium cynomolgi bastianellii, was accomplished by means of a highly specific indirect immunofluorescence technique (ifa) applied to hepatic tissue fixed in carnoy's solution. the 48-hour forms appeared as round-to-slightly-oval bodies of average mean diameter 3.0 micrometers (9 parasites) and lying with the cytoplasm of individual hepatic parenchymal cells; each possessed one to three ... | 1981 | 7011070 |
| timing of stages and changes in numbers of multiply-infected erythrocytes during the asexual cycle of plasmodium cynomolgi bastianellii. | previous evaluations of the timing of developing stages in the erythrocytic cycle of the simian malaria parasite, plasmodium cynomolgi, a frequently used model for relapsing malaria in man, have depended on procurement of blood samples at 4- or 6-hourly intervals. this brief report describes the blood cycle as determined from hourly bleedings, thus providing a more discriminating sequence usable for immunochemical or biochemical study of specific stages. the approximate timing of development for ... | 1983 | 6859395 |
| appraisals of compounds of diverse chemical classes for capacities to cure infections with sporozoites of plasmodium cynomolgi. | compounds (265) of widely diverse structures were appraised for radical curative activity in rhesus monkeys infected with sporozoites of the b strain of plasmodium cynomolgi, using an evaluation system that provided a preliminary assessment with from 0.1-1.0 g of compound and tests against one to five active infections. none of 32 compounds in a miscellaneous structure category, none of seven agents of antibiotic origin, none of 12 1,5-naphthyridines, and none of seven 7-aminoquinolines exhibite ... | 1983 | 6837838 |
| synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogues as potential antiparasitics. | a series of 2,4-disubstituted 8-aminoquinoline analogues were synthesized and evaluated against plasmodium berghei in mice and leishmania donovani in hamsters. 8-[[6-(diethylamino)hexyl]amino]-2-ethyl-6-methoxy-4-methylquinoline (8a) possessed significant activity against l. donovani. 2-ethyl-4-methylprimaquine (7a) was evaluated against plasmodium cynomolgi in rhesus monkey and found to have activity equal to that of primaquine. | 1980 | 6770089 |
| plasmodium cynomolgi: folic acid antagonist combinations for treatment of malaria in rhesus monkeys. | 1980 | 6767622 | |
| antimalarials. 13. 5-alkoxy analogues of 4-methylprimaquine. | a series of nuclear and side-chain analogues of 4-methylprimaquine incorporating an alkoxy group in the 5-position of the quinoline nucleus has been prepared. the compounds were tested for suppressive antimalarial activity against plasmodium berghei in mice and for radical curative antimalarial activity against plasmodium cynomolgi in the rhesus monkey. although the toxicity problems characteristic of the 8-aminoquinolines were not overcome, several of the compounds, surprisingly, were highly ef ... | 1982 | 6750123 |
| sporozoite-induced plasmodium cynomolgi infections in captive born macaca fascicularis. | capability of captive born cynomolgus monkeys to substitute for rhesus in the plasmodium cynomolgi radical curative antimalarial drug development model was examined. eighteen monkeys divided into 3 groups were given standard or high doses of sporozoites intravenously. one group of 4 received 0.8 - 1.6 x 10(6) and a second group of 8 received 0.3 - 1.0 x 10(7) sporozoites. the third group of 6 was splenectomized and then received 3.0 - 4.0 x 10(6). the 2 groups of intact monkeys developed a persi ... | 1984 | 6740373 |
| [biological characteristics of simian malaria model of plasmodium cynomolgi-anopheles stephensi system and its response to antimalarials]. | 1983 | 6679168 | |
| relationships between chemical structures of 8-aminoquinolines and their capacities for radical cure of infections with plasmodium cynomolgi in rhesus monkeys. | evaluation of 200 8-aminoquinolines for the capacities to effect radical cure of infections with sporozoites of plasmodium cynomolgi in rhesus monkeys led to identification of 34 derivatives with activity equal or superior to that of primaquine and to characterization of substituents on the quinoline nucleus and side chain that favored or prejudiced curative activity. of the 34 derivatives, 19 were as active as primaquine, 9 were twice as active, and 6 were four times as active. with respect to ... | 1983 | 6660845 |
| an evaluation of plasmodium cynomolgi bastianellii and plasmodium knowlesi antigens in the seroepidemiology of human malaria using indirect haemagglutination test. | 1984 | 6536544 | |
| [a combined regimen of pyronaridin-artemether-chloroquine (pac) for the treatment of plasmodium cynomolgi infection in the rhesus monkey]. | 1984 | 6536163 | |
| [studies on the biological characteristics and the strain-type of plasmodium cynomolgi maintained in china]. | 1984 | 6518634 | |
| [continuous cultivation of erythrocytic plasmodium cynomolgi in vitro]. | 1984 | 6509747 | |
| continuous in vitro cultivation of erythrocytic plasmodium cynomolgi. | 1984 | 6432472 | |
| evaluation of plasmodium cynomolgi b antigen in enzyme linked immunosorbent assay (elisa) test for human malaria. | 1984 | 6399263 | |
| activities of respository preparations of cycloguanil pamoate and 4,4'-diacetyldiaminodiphenylsulfone, alone and in combination, against infections with plasmodium cynomolgi in rhesus monkeys. | the studies summarized in this report were concerned with the capacities of repository preparations of cycloguanil pamoate (cgt-p) to protect rhesus monkeys against infections with drug-susceptible and pyrimethamine-resistant strains of plasmodium cynomolgi. administered intramuscularly as a suspension in an oleaginous vehicle, cgt-p (i) provided long-term protection against single and repetitive challenges of rhesus monkeys with sporozoites of the drug-susceptible b and ro strains, (ii) effecte ... | 1984 | 6393864 |
| evolutionary relatedness of plasmodium species as determined by the structure of dna. | malaria parasites can be grouped evolutionarily by analysis of dna composition and genome arrangement. those that vary widely with regard to host range, morphology, and biological characteristics fit into only a small number of distinctive groups. the dna of the human parasite plasmodium falciparum fits into a group that includes rodent and avian malarias and is unlike the dna of other primate malaria parasites. the dna of plasmodium vivax, which is also a human parasite, fits into a distinctly ... | 1984 | 6382604 |
| malaria parasites--discovery of the early liver form. | infections of mammalian malaria parasites start when sporozoites from an infected anopheline mosquito are injected into the bloodstream of the host. the sporozoites enter the hepatocytes and become transformed into exoerythrocytic schizonts. since the discovery of the primate parasite plasmodium cynomolgi in monkey hepatocytes and the rodent parasite plasmodium berghei in hamster hepatocytes, the ultrastructure of these stages has been extensively studied both in primate and rodent plasmodia. th ... | 1983 | 6339945 |
| interactions between oral contraceptives and malaria infections in rhesus monkeys. | the interaction of oral contraceptives with malaria infection (plasmodium cynomolgi b and p. coatneyi) in adult female rhesus monkeys (macaca mulatta) was studied. the oral contraceptives (norinyl and ovral-28) were administered for 12 consecutive menstrual cycles, from day 5 to 25 of each cycle, at either (1/3) of the human dose of norinyl (norethisterone 0.33 mg + ethinylestradiol 0.012 mg) or (1/6) of the human dose of ovral-28 (norgestrel 0.083 mg + ethinylestradiol 0.008 mg).the animals wer ... | 1984 | 6335851 |
| [antimalarial activities of hydroxypiperaquine and its phosphate against plasmodium berghei and plasmodium cynomolgi]. | 1984 | 6232823 | |
| [effects of nitroquine on sporogenic cycle of plasmodium cynomolgi]. | 1982 | 6219546 | |
| [establishment of monkey model of plasmodium cynomolgi-anopheles stephensi system and its use for tissue shizontocide test]. | 1982 | 6216007 |