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hurdle enhancement of slightly acidic electrolyzed water antimicrobial efficacy on chinese cabbage, lettuce, sesame leaf and spinach using ultrasonication and water wash.slightly acidic electrolyzed water (saew) is well known as a good sanitizer against foodborne pathogens on fresh vegetables. however, microbial reductions from saew treatment are not enough to ensure produce safety. therefore, it is necessary to improve its antimicrobial efficiency by combining it with other appropriate approaches. this study examined the microbicidal activity of saew (ph 5.2-5.5, oxidation reduction potential 500-600 mv, available chlorine concentration 21-22 mg/l) on chinese c ...201323764218
impact of mine waste dumps on growth and biomass of economically important crops.the present study aimed to investigate the effect of magnesite and bauxite waste dumps on growth and biochemical parameters of some edible and economically important plants such as vigna radiata, v. mungo, v. unguiculata, eleusine coracana, cajanus cajan, pennisetum glaucum, macrotyloma uniflorum, oryza sativa, sorghum bicolour, sesamum indicum, ricinus communis, brassica juncea, gossypium hirsutum and jatropha curcas. the growth rate of all the crops was observed in the range of 75 to 100% in m ...201223741803
a study on the method of taila bindu pariksha (oil drop test).taila bindu pariksha, an ancient method of urine examination for ascertaining the prognosis of diseases, was very popular in the medieval period, the use of which became obsolete after 17(th) century ad. technique of this test is very crude and there are chances of variations in the observations. to revive this technique, it is necessary that the methodology of this test should be standardized so that the observations could be reproducible. to standardize the technique, apparently healthy volunt ...201223723648
therapeutic effect of korean red ginseng extract on infertility caused by polycystic ovaries.polycystic ovarian syndrome (pcos) is a very common endocrine disorder in women of reproductive age. nerve growth factor (ngf) may be involved in the pathogenesis of pcos. in this study, we investigated the effect of korean red ginseng extract (krge) on the ovarian morphology and ngf expression in an estradiol valerate (ev)-induced rat model. polycystic ovaries were induced by a single intramuscular injection of estadiol valerate (4 mg, dissolved in sesame oil) in adult cycling rats. krge was ad ...201123717068
analysis of glabrous canary seeds by elisa, mass spectrometry, and western blotting for the absence of cross-reactivity with major plant food allergens.glabrous (hairless) canary seed belongs to the poaceae (gramineae) family and could serve as an alternative source of gluten-free cereal grain. in this study, allergenic cross-reactivities between hairless, dehulled canary seeds (phalaris canariensis) and major allergenic proteins from gluten, soy, peanuts, tree nuts, sesame, and mustard were studied using commercial enzyme-linked immune sorbent assay (elisa) kits specific for these target allergens. mass spectrometry (ms) and immunoblotting wer ...201323706175
iaa-producing penicillium sp. nics01 triggers plant growth and suppresses fusarium sp.-induced oxidative stress in sesame (sesamum indicum l.).application of rhizospheric fungi is an effective and environmentally friendly method of improving plant growth and controlling many plant diseases. the current study was aimed to identify phytohormone-producing fungi from soil, to understand their roles in sesame plant growth, and to control fusarium disease. three predominant fungi (pnf1, pnf2, and pnf3) isolated from the rhizospheric soil of peanut plants were screened for their growth-promoting efficiency on sesame seedlings. among these iso ...201323676921
transfer of terpenes from essential oils into cow milk.the objective of this study was to investigate the transfer of volatile terpenes from caraway seed and oregano plant essential oils into cow's milk through respiratory and gastrointestinal exposure. essential oils have potential applications as feed additives because of their antimicrobial properties, but very little work exists on the transfer of their volatile compounds into milk. lactating danish holstein cows with duodenum cannula were used. gastrointestinal exposure was facilitated by infus ...201323628249
purification, gene cloning, and biochemical characterization of a β-glucosidase capable of hydrolyzing sesaminol triglucoside from paenibacillus sp. kb0549.the triglucoside of sesaminol, i.e., 2,6-o-di(β-d-glucopyranosyl)-β-d- glucopyranosylsesaminol (stg), occurs abundantly in sesame seeds and sesame oil cake and serves as an inexpensive source for the industrial production of sesaminol, an anti-oxidant that displays a number of bioactivities beneficial to human health. however, stg has been shown to be highly resistant to the action of β-glucosidases, in part due to its branched-chain glycon structure, and these circumstances hampered the efficie ...201323593237
7,12-dimethylbenz[a]anthracene-induced malignancies in a mouse model of menopause.ovarian cancer has a high mortality rate because there are few symptoms in early disease development. the incidence of ovarian cancer increases in women after menopause. understanding early events in this disease can best be achieved by using animal models. therefore, the objective of this study was to develop and track the onset of ovarian tumorigenesis in mice mimicking characteristics of postmenopausal epithelial cancer in women. female b6c3f1 mice (age, 28 d) received 4-vinylcyclohexene diep ...201323561932
penicillium sp. mitigates fusarium-induced biotic stress in sesame plants.fusarium-infected sesame plants have significantly higher contents of amino acids (asp, thr, ser, asn, glu, gly, ala, val, met, ile, leu, tyr, phe, lys, his, try, arg, and pro), compared with their respective levels in the healthy control. these higher levels of amino acids induced by fusarium infection were decreased when penicillium was co-inoculated with fusarium. compared with the control, fusarium-infected plants showed higher contents of palmitic (8%), stearic (8%), oleic (7%), and linolen ...201323479415
determination of aflatoxins b1, b2, g1, and g2 in olive oil, peanut oil, and sesame oil using immunoaffinity column cleanup, postcolumn derivatization, and liquid chromatography/fluorescence detection: collaborative study.the accuracy, repeatability, and reproducibility characteristics of a method using immunoaffinity column (iac) cleanup with postcolumn derivatization and lc with a fluorescence detector (fld) for determination of aflatoxins (afs; sum of afs b1, b2, g1, and g2) in olive oil, peanut oil, and sesame oil have been established in a collaborative study involving 15 laboratories from six countries. blind duplicate samples of blank, spiked at levels ranging from 0.25 to 20.0 microg/kg for af, were analy ...201223451385
influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to long-lived, f1 hybrid mice.phytonutrients reportedly extend the life span of caenorhabditis elegans, drosophila, and mice. we tested extracts of blueberry, pomegranate, green and black tea, cinnamon, sesame, and french maritime pine bark (pycnogenol and taxifolin), as well as curcumin, morin, and quercetin for their effects on the life span of mice. while many of these phytonutrients reportedly extend the life span of model organisms, we found no significant effect on the life span of male f1 hybrid mice, even though the ...201323432089
purification and fermentation in vitro of sesaminol triglucoside from sesame cake by human intestinal microbiota.sesaminol triglucoside (stg), the most abundant lignan glycoside existing in sesame cake/meal, has exhibited various biological activities. however, little information about its in vitro fermentation with intestinal microbiota is available. therefore, the effect of stg from sesame cake on the fermentation of human fecal microbiota was evaluated. first, high-purity stg was successfully prepared from defatted sesame cake by extraction with 80% ethanol and simple purification procedures of polyamid ...201323387872
curcumin derivatives promote schwann cell differentiation and improve neuropathy in r98c cmt1b mice.charcot-marie-tooth disease type 1b is caused by mutations in myelin protein zero. r98c mice, an authentic model of early onset charcot-marie-tooth disease type 1b, develop neuropathy in part because the misfolded mutant myelin protein zero is retained in the endoplasmic reticulum where it activates the unfolded protein response. because oral curcumin, a component of the spice turmeric, has been shown to relieve endoplasmic reticulum stress and decrease the activation of the unfolded protein res ...201223250879
[studies on the food allergenic proteins contained in pharmaceutical excipients].most drugs contain pharmaceutical excipients. these are pharmacologically inactive substances used as vehicles for the active ingredients of a medication. some of these pharmaceutical excipients are produced from allergenic foods (e.g., milk, egg, peanut, soybean, and sesame) and removing proteins completely from such excipients is difficult. therefore, if individuals with food allergy consume drugs containing allergenic food-derived excipients, eliminating the risk of developing specific allerg ...201223243989
formulation of a drinkable peanut-based therapeutic food for malnourished children using plant sources.high ingredient costs continue to hamper local production of therapeutic foods (tfs). development of formulations without milk, the most expensive ingredient, is one way of reducing cost. this study formulated a ready-to-drink peanut-based tf that matched the nutrient composition of f100 using plant sources. three least cost formulations namely, a, b and c were designed using computer formulation software with peanuts, beans, sesame, cowpeas and grain amaranth as ingredients. a 100 g portion of ...201323198736
multistate outbreak of salmonella serotype bovismorbificans infections associated with hummus and tahini--united states, 2011.on september 27, 2011, three clinical isolates of salmonella enterica serotype bovismorbificans with indistinguishable pulsed-field gel electrophoresis (pfge) patterns were identified by the district of columbia public health laboratory (phl). human infection with s. bovismorbificans is rare in the united states. through query of pulsenet, the national molecular subtyping network for foodborne disease surveillance, six additional cases with indistinguishable pfge patterns were identified in thre ...201223169315
tunable nano-oleosomes derived from engineered yarrowia lipolytica.oleosomes are discrete organelles filled with neutral lipids surrounded by a protein-embedded phospholipid monolayer. their simple yet robust structure, as well as their amenability to biological, chemical, and physical processing, can be exploited for various biotechnology applications. in this study, we report facile biosynthesis of functionalized oleosomes within oleaginous yeast yarrowia lipolytica, through expression of oleosin fusion proteins. by fusing a cdna clone of a sesame oleosin wit ...201323096765
effects of bilobalide on anxiety, spatial learning, memory and levels of hippocampal glucocorticoid receptors in male kunming mice.with various constituents in ginkgo biloba extract, the detailed internal mechanism underlying a reduction in anxiety and improvements to learning and memory from gbe is not well understood. the present study investigated whether bilobalide, an important constituent in gbe, could affect anxiety, spatial learning and memory in male mice and whether hippocampal glucocorticoid receptor expression is associated with alteration in these behaviors. mice were treated orally either with sesame seed oil ...201223083816
use of specific ige and skin prick test to determine clinical reaction severity.aims: to determine whether specific ige and skin prick test correlate better in predicting reaction severity during a double-blinded placebo controlled food challenge (dbpcfc) for egg, milk, and multiple tree nut allergens. study design: prospective study. place and duration of study: department of pediatrics, stanford university school of medicine, august 2009 and ongoing. methodology: we examined the reaction severity of twenty-four subjects to nine possible food allergens: milk, egg, almond, ...201122993721
biotechnological potential of agro residues for economical production of thermoalkali-stable pectinase by bacillus pumilus dcsr1 by solid-state fermentation and its efficacy in the treatment of ramie fibres.the production of a thermostable and highly alkaline pectinase by bacillus pumilus dcsr1 was optimized in solid-state fermentation (ssf) and the impact of various treatments (chemical, enzymatic, and in combination) on the quality of ramie fibres was investigated. maximum enzyme titer (348.0 ± 11.8 ug(-1) dbb) in ssf was attained, when a mixture of agro-residues (sesame oilseed cake, wheat bran, and citrus pectin, 1 : 1 : 0.01) was moistened with mineral salt solution (a(w) 0.92, ph 9.0) at a su ...201222928091
an improved allele-specific pcr primer design method for snp marker analysis and its application. 201222920499
integrated approach for disease management and growth enhancement of sesamum indicum l. utilizing azotobacter chroococcum tra2 and chemical fertilizer.azotobacter chroococcum tra2, an isolate of wheat rhizosphere displayed plant growth promoting attributes including indole acetic acid, hcn, siderophore production, solubilization of inorganic phosphate and fixation of atmospheric nitrogen. in addition, it showed strong antagonistic effect against macrophomina phaseolina and fusarium oxysporum. it also caused degradation and digestion of cell wall components, resulting in hyphal perforations, empty cell (halo) formation, shrinking and lysis of f ...201222828791
efficacy of natural products against callosobruchus chinensis (coleoptera: bruchidae) in nepal.this study was conducted to determine the efficacy of local natural products against the beetle, callosobruchus chinensis l. (coleoptera: bruchidae), in stored chickpea cicer arietinum l. (fabaceae) in chitwan, nepal. five natural products and one synthetic pesticide (malathion) and two storage regimes (aluminum sheet bin vs. jute bags with plastic lining) were tested for their effect on stored pulse with respect to damage by c. chinensis. the five natural products included xanthoylum armatum dc ...201222812152
production of prodigiosin and chitinases by tropical serratia marcescens strains with potential to control plant pathogens.the potential of three serratia marcescens strains (cffsur-b2, cffsur-b3 and cffsur-b4) isolated from tropical regions in mexico to inhibit the mycelial growth and conidial germination of colletotrichum gloeosporioides, causal agent of fruit anthracnose, was evaluated. the ability of these strains to produce prodigiosin and chitinases when cultivated in oil seed-based media (peanut, sesame, soybean and castor bean) and in luria-bertani medium was determined. all of the strains exhibited similar ...201122806790
diversity of plant oil seed-associated fungi isolated from seven oil-bearing seeds and their potential for the production of lipolytic enzymes.commercial oil-yielding seeds (castor, coconut, neem, peanut, pongamia, rubber and sesame) were collected from different places in the state of tamil nadu (india) from which 1279 endophytic fungi were isolated. the oil-bearing seeds exhibited rich fungal diversity. high shannon-index h' was observed with pongamia seeds (2.847) while a low index occurred for coconut kernel-associated mycoflora (1.018). maximum colonization frequency (%) was observed for lasiodiplodia theobromae (176). dominance i ...201122806781
formulation design and in vivo antimalarial evaluation of lipid-based drug delivery systems for oral delivery of β-arteether.β-arteether, an effective artemisinin derivative, is used in the treatment of malaria but available only as an intramuscular injection. the objective of this work was to develop lipid-based formulations for oral administration of β-arteether. self-emulsifying drug delivery systems (seddss) of low cost and with accessible excipients (groundnut or sesame oil, maisine 35-1, tween 80 or cremophor el, and absolute ethanol) were formulated. in 250 ml of simulated gastric medium, 1g of these sedds solu ...201222609572
ethno medical studies in kailasagirikona forest range of chittoor district, andhra pradesh.the present study reveals the ethno botanical studies on uses of medicinal plants in kailasagiri forest range of chittoor district, andhra pradesh. role of these studies in rural and forest economies is immense. tribal people of this area have authentic information on medicinal values of different plant parts like leaves, fruits, flowers, seeds, stem bark, tubers and roots. they have been using these parts in the form of paste, powder, juice, decoction, infusion and also in crude form, with othe ...200922557350
ethno medical studies in talakona forest range of chittor district, andhra pradesh.the flora of talakona forest division has been studied for its ethnomedicinal wealth (hemadri et al, madhava chetty et al). these studies have contributed immensely to the rural and forest economy. the present study revealed the medicinal use of 66 species of plants distributedin 40families. many of the usages were unknown till date. about 65% of the medicinal applications of plants are for internal purposes. majority of the external formulations are for conditions affecting the integumentary sy ...200922557321
phytochemical analysis of achyranthes aspera and its activity on sesame oil induced lipid peroxidation.the effect of achyranthes aspera on lipid peroxidation were studied in rats fed with sesame oil. increase in the levels of lpo in sesame oil treated groups returned towards normalcy in the plant extract treated groups revealing the antioxidant potential of the plant. phytochemical studies revealed the presence of secondary metabolites. according to the results obtained achyranthes aspera inhibited ferrous ascorbate stimulated lpo.200722557252
hypolipidemic efficacy of achyranthes aspera on lipid profile in sesame oil fed rats.the present study was designed to evaluate the antihyperlipidemic effect of aqueous extract of achyranthes aspera a in experimental rats fed with diet containing sesame oil. hyperlipidemia and the effect of achyranthes aspera in experimental rats were studied by assessing parameters such as cholesterol, phospholipids, freefattyacids and triglycerides in serum, liver, and heart and kidney tissues. the levels of hdl, ldl, vldl and atherogenic index were assessed. hyperlipidemia in experimental rat ...200622557207
comparative potential therapeutic effect of sesame oil and peanut oil against acute monocrotaline (crotalaria) poisoning in a rat model.many crotalaria plant species contain hepatotoxic pyrrolizidine alkaloids (such as monocrotaline) that can cause acute and chronic poisoning in cattle and other animals.201622443367
sensory characteristics and cross-cultural consumer acceptability of bulgogi (korean traditional barbecued beef).bulgogi (korean traditional barbecued beef) is the most well-known korean food to foreigners. there are, however, few studies on its sensory characteristics and consumer acceptability. this study was performed to identify the sensory attributes of bulgogi samples prepared with different formulation and to compare the consumer acceptability in korea and the united states. bulgogi samples were prepared with varying levels of sugar and soy sauce with/without garlic or sesame oil. descriptive analys ...201622417445
effects of early prepubertal exposure to bisphenol a on the onset of puberty, ovarian weights, and estrous cycle in female mice.bisphenol a (bpa) is a chemical used extensively to manufacture plastics and epoxy resin liners for food and beverage cans. bpa, with properties similar to estrogen, has endocrine-disrupting effects. in the present study, we examined the effects of early prepubertal bpa exposure on the onset of puberty and reproductive parameters such as estrous cycle and reproductive organ weights in female mice.201122384422
comparing analgesic effects of a topical herbal mixed medicine with salicylate in patients with knee osteoarthritis.knee osteoarthritis is the most common cause of disability among people and it is a common disease of joints that can lead to cartilage damage. in this study the analgesic effects of a herbal ointment containing cinnamon, ginger, mastic (saghez) and sesame oil is compared with salicylate ointment in patients suffering from knee osteoarthritis. it was a double-blind randomized controlled trail study. patients with diagnosed arthritis were involved in the study and they were divided in two groups ...201122308653
potential of herbs in skin protection from ultraviolet radiation.herbs have been used in medicines and cosmetics from centuries. their potential to treat different skin diseases, to adorn and improve the skin appearance is well-known. as ultraviolet (uv) radiation can cause sunburns, wrinkles, lower immunity against infections, premature aging, and cancer, there is permanent need for protection from uv radiation and prevention from their side effects. herbs and herbal preparations have a high potential due to their antioxidant activity, primarily. antioxidant ...201122279374
effect of flax addition on the flavor profile and acceptability of bagels.bakery products containing flaxseed, a rich source of alpha linolenic acid (ala), may provide health benefits. however, the effect of adding flaxseed, especially in the high amounts required for use as the food supplement in clinical trials (23% by weight of the raw ingredients), may affect the flavor characteristics and consumer acceptability. sensory attributes of bagels containing 30 g of milled flaxseed were evaluated by a 9 member trained panel using a descriptive test and by 89 participant ...201222260132
food-induced anaphylaxis.food-induced anaphylaxis (fia) is a serious allergic reaction that may cause death rapidly in otherwise healthy individuals. there is no universal agreement on its definition or criteria for diagnosis. hospital admissions for fia have more than doubled in the last decade. food is one of the most common causes of anaphylaxis, with most surveys indicating that food-induced reactions account for 30% to 50% of cases. the most commonly implicated foods are peanut, tree nuts, milk, eggs, sesame seeds, ...201122244239
progesterone inhibits uterine gland development in the neonatal mouse uterus.uterine glands and their secretions are required for conceptus (embryo/fetus and associated placenta) survival and development. in most mammals, uterine gland morphogenesis or adenogenesis is a uniquely postnatal event, however little is known about the mechanisms governing that developmental event. in sheep, progestin treatment of neonatal ewes permanently ablated differentiation of the endometrial glands. similarly, progesterone (p4) inhibits adenogenesis in neonatal mouse uterus. thus, p4 can ...201222238285
establishment of regeneration and transformation system in egyptian sesame (sesamum indicum l.) cv. sohag.sesame (sesamum indicum l.) is an important oil crop in many tropical and sub-tropical regions of the world, yet has received little attention in applying modern biotechnology in its improvement due to regeneration and transformation difficulties. here within, we report the successful production of transgenic fertile plants of sesame (cv. sohag 1), after screening several cultivars. agrobacterium tumefaciens- carrying the pbi121 plasmid {neomycin phosphotransferase gene (nptii) and a β-glucuroni ...201122179191
Nicotine and vascular endothelial dysfunction in female ovariectomized rats: role of estrogen replacement therapy.Objectives The protective effects of estrogen replacement therapy (ERT) against oxidative injury and endothelial dysfunction in the aortic tissues induced with nicotine in ovariectomized (OVX) rats were investigated. Methods Female rats were divided into a sham-operated group (n = 8) and four groups in which OVX rats received either vehicle (0.1 ml sesame oil, i.m., n = 8), or nicotine (0.1 mg/kg, s.c., n = 8), or estradiol benzoate (0.1 mg/kg, i.m., n = 8), or both nicotine and estradiol benz ...201222150678
differential effects of progesterone and medroxyprogesterone on delay eyeblink conditioning in ovariectomized rats.ovarian hormones modulate acquisition processes involved in classical conditioning. although progesterone has been indirectly implicated, its role in classical conditioning of the eyeblink response has not been directly investigated. we assessed the effects of daily dosing of progesterone or medroxyprogesterone (mpa), a non-metabolized synthetic progestin, upon the acquisition of a classically conditioned eyeblink response in ovariectomized (ovx) female rats. rats were dosed 4h prior to each tra ...201222138327
methods for long-term 17β-estradiol administration to mice.rodent models constitute a cornerstone in the elucidation of the effects and biological mechanisms of 17β-estradiol. however, a thorough assessment of the methods for long-term administration of 17β-estradiol to mice is lacking. the fact that 17β-estradiol has been demonstrated to exert different effects depending on dose emphasizes the need for validated administration regimens. therefore, 169 female c57bl/6 mice were ovariectomized and administered 17β-estradiol using one of the two commonly u ...201222137913
effect of estrogen therapy on adipocytokines in ovariectomized-aged rats.aim:  obesity is a chronic disease that is characterized by excessive accumulation of body fat. the physiological changes associated with estrogen deprivation in menopause have a significant impact on total body fat and adipose tissue distribution. adipocytokines, such as adiponectin and leptin are related to adipose tissue, and their levels are affected by estrogen. the aim of the present study was to investigate the alteration of adipocytokine levels with estrogen therapy. material and methods ...201122136746
comparative effects of sesame seed lignan and flaxseed lignan in reducing the growth of human breast tumors (mcf-7) at high levels of circulating estrogen in athymic mice.flaxseed (fs) has a breast tumor-reducing effect, possibly because of its high content of secoisolariciresinol diglucoside (sdg) lignan. sesame seed (ss) is rich in the lignan sesamin (ses) but is non-protective. both lignans are metabolized to estrogen-like enterodiol and enterolactone. the objective of this study was to differentiate the effects of sdg and ses on established human estrogen receptor-positive breast tumors (mcf-7) in athymic mice with high serum estrogen to help explain the diff ...201122136581
steroid 5α-reductase in adult rat brain after neonatal testosterone administration.testosterone (t) plays an important role in developing brain, dictating sex-specific behavior and physiology. 3α,5α-reduced neurosteroids also regulate reproductive behavior. the key enzyme in the biosynthesis of these neurosteroids is 5α-reductase (5α-r), expressed as two isozymes, 5α-r1 and 5α-r2. in this study, t and sesame oil (vehicle) were administered during postnatal sexual differentiation of the central nervous system (cns) and mrna levels of 5α-r isozymes, were measured using quantitat ...201122131296
[open sesame: regulation of hepatitis c virus entry into hepatocytes]. 201122130016
how is sesamin metabolised in the human liver to show its biological effects?introduction: sesamin is a major lignan found in sesame and is known to have various biological effects. some of these biological effects occur following its metabolic conversion to corresponding catechols and, therefore, the study of sesamin metabolism is quite important. there is currently a need to identify the enzymes responsible for metabolism of sesamin so that scientists will be more able to predict sesamin-drug interactions. areas covered: the authors reviewed all the published lit ...201222098100
neuroprotective effect of sesame seed oil in 6-hydroxydopamine induced neurotoxicity in mice model: cellular, biochemical and neurochemical evidence.natural antioxidants have shown a remarkable reduction in oxidative stress due to excess formation of reactive oxygen species by enhancing antioxidant mechanism in the neurodegenerative disorders. sesame seed oil (so) is one of the most important edible oil in india as well as in asian countries and has potent antioxidant properties thus the present study evaluated the neuroprotective effect of so by using 6-hydroxydopamine (6-ohda)-induced parkinson's disease model in mice. the mice were fed an ...201122089932
Cypermethrin induced damage in genomic DNA and histopathological changes in brain and haematotoxicity in rats: The protective effect of sesame oil.The protective effect of sesame oil against cypermethrin-induced brain toxicity was studied. Female rats were orally treated with cypermethrin, sesame oil and their combination for 30 consecutive days. The results showed that cypermethrin increased thiobarbituric acid-reactive substances (TBARS), and decreased glutathione (GSH) and the activities of the antioxidant enzymes. Brain injury was confirmed by histopathological changes and DNA damage. Also, the reduction in the activities of acetylchol ...201122085743
evaluation of glycemic and oxidative/antioxidative status in the estradiol valerate-induced pcos model of rats.the aim of this study was to show glycemic and oxidative/antioxidative status (goas) in rats with estradiol valerate (ev)-induced polycystic ovarian syndrome.201122071112
Prophylactic and Therapeutic Effects of a Subcutaneous Injection of Sesame Oil Against Iron-Induced Acute Renal Injury in Mice.BACKGROUND: Iron intoxication causes acute nephrotoxicity in animals and humans. Sesame oil, a healthful food, increases resistance to lipid peroxidation and protects against multiple organ injury in various animal models. The authors examined the prophylactic and therapeutic effects of a subcutaneous injection of sesame oil against iron-induced acute renal injury in mice. METHODS: Iron intoxication in mice was induced with an intraperitoneal injection (2 mg/kg) of ferric-nitrilotriacetate (F ...201122038207
abnormal development of intrinsic innervation in murine embryos with anorectal malformations.introduction: constipation, soiling, and incontinence are common problems after definitive repair of anorectal malformations (arms) in children. we studied the expression of substance p (sp), vasoactive intestinal peptide (vip), and c-kit in the rectum of murine embryos with or without arms at later developmental stages. methods: on the 9th embryonic day (e9), pregnant institute of cancer research mice were fed e ...201122033771
Role of apoptosis in retinoic acid-induced cleft palate.Although the mechanism by which retinoic acid (RA) induces cleft palate has been intensely investigated, some controversies remain. Some researchers argue that RA inhibits apoptosis, resulting in a failure of palatal shelves to fuse, whereas others propose that RA disrupts elevation or retards the growth of palatal shelves. This study investigated the mechanism underlying RA-induced formation of cleft palate in the rat, focusing mainly on the role of apoptosis.201121959388
effect of j-coupling on lipid composition determination with localized proton magnetic resonance spectroscopy at 9.4 t.to demonstrate, at 9.4 t, that j-coupling interactions exhibited by lipid protons affects lipid composition determination with a point resolved spectroscopy (press) sequence.201121953706
formulation and evaluation of an in situ gel forming system for controlled delivery of triptorelin acetate.the novel physical hydrogels composed of chitosan or its water soluble derivatives such as carboxymethyl chitosan (cmch) and sodium carboxymethyl chitosan (nacmch) and opened ring polyvinyl pyrrolidone (op-pvp) were used as a controlled delivery system for triptorelin acetate, a luteinizing-releasing hormone agonist. the in situ gel forming system designed according to physical interactions such as chains entanglements and hydrophilic attractions especially h-bonds of chitosan and/or nacmch and ...201121946260
ameliorative effects of herbal combinations in hyperlipidemia.the roots of glycyrrhiza glabra, withania somnifera, asparagus racemosus, and chlorophytum borivilianum and seeds of sesamum indicum are ayurvedic medicinal plants used in india to treat several ailments. our previous studies indicated that these plants possess hypolipidemic and antioxidant potential. the present study was aimed at investigating the composite effects of these plants on hypercholesterolemic rats. three different combinations (5 gm%, given for four weeks) used in this study effect ...201121941605
effects of in utero exposure to bisphenol a or diethylstilbestrol on the adult male reproductive system.the objective of this study was to determine whether in utero exposure to bisphenol a (bpa) induced reproductive tract abnormalities in the adult male testis. using the c57/bl6 mouse, we examined sex-organ weights, anogenital distance, and testis histopathology in adult males exposed in utero via oral gavage to sesame oil, 50 µg/kg bpa, 1000 µg/kg bpa, or 2 µg/kg diethylstilbestrol (des) as a positive control from gestational days 10 to 16. no changes in sperm production or germ cell apoptosis w ...201121922642
effect of oil pulling on halitosis and microorganisms causing halitosis: a randomized controlled pilot trial.oil pulling therapy has been used extensively as a traditional indian folk remedy for many years for strengthening teeth, gums, and jaws and to prevent decay, oral malodor, bleeding gums and dryness of throat, and cracked lips.201121911944
effects of sesamol on apoptosis and steroidogenesis in ma-10 mouse leydig tumor cells.sesamol, a pure compound of sesame, has been reported to have antitumor effects. in the present study, the apoptotic and steroidogenic effects of sesamol on ma-10 cells, a mouse leydig tumor cell line, was investigated by morphological observations, cell viability assay, flow cytometry analysis, radioimmunoassay, and immunoblotting assay. we found that the number of rounded-up cells increased as the treatment duration of sesamol increased from 3 to 24 h and that the plasma membrane blebbing phen ...201121863802
The influence of corticosterone on antizyme gene expression in early regenerating rat liver.Antizyme 1, a specific inhibitor of Ornithine decarboxylase (ODC), plays a critical role in cell proliferation. Little is known about the impact of glucocorticoid on antizyme expression in the regenerating liver. In this paper, the effect of corticosterone on the gene expression of antizyme 1 in early regenerating rat liver induced by partial hepatectomy (PH) was investigated.201121861313
Glutamate and the aggression neural circuit in adolescent anabolic steroid-treated Syrian hamsters (Mesocricetus auratus).Adolescent exposure to anabolic androgenic steroids (AAS) alters the development and activity of the glutamate neural system in the latero-anterior hypothalamus (LAH) in hamsters (Mesocricetus auratus); that is, an important neural component of the adolescent AAS-induced aggressive response. In this article, we used retrograde tracing to investigate glutamate-specific alterations in the connections between the LAH and several other nuclei implicated in adolescent AAS-induced aggression. Briefly, ...201121859171
Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice.Interactions between environmental contaminants can lead to non-additive effects that may affect the toxicity and risk assessment of a mixture. Comprehensive time course and dose-response studies with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), non-dioxin-like 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) and their mixture were performed in immature, ovariectomized C57BL/6 mice. Mice were gavaged once with 30 µg/kg TCDD, 300 mg/kg PCB153, a mixture of 30 µg/kg TCDD with 300 mg/kg PCB153 (MIX) or se ...201121851831
hypermethylation of estrogen receptor promoter region in adult testis of rats exposed neonatally to bisphenol a.bisphenol a (bpa) is an estrogenic endocrine disruptor commonly used in manufacture of polycarbonate plastics and epoxy resins. due to its ubiquitous presence in the environment, health concerns are increasing. earlier studies from our group have shown that neonatal exposure of male rats to bpa affected spermatogenesis leading to impairment in fertility during adulthood. further we also observed an altered gene expression of er+¦ and er+¦ in adult testis upon bpa exposure. based on these results ...201121827818
antioxidant potential of sesamol and its role on radiation-induced dna damage in whole-body irradiated swiss albino mice.sesamol (sm) is a dietary phytochemical present in the processed sesame oil. in this present study we have evaluated the antioxidant potential of sm and its role in the protection of radiation-induced dna damage in +¦-irradiated mice. the antioxidant properties of sm were evaluated by using different in vitro antioxidant assays. sm shows scavenging effect against hydroxyl (oh), superoxide anion (o(2)(-)), nitric oxide, 2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid radical cation (abts(+) ...200921784002
photoprotective effect of sesamol on uvb-radiation induced oxidative stress in human blood lymphocytes in vitro.normal lymphocytes are highly sensitive to the damaging effect of radiation and undergo cell death. in the present study, the photoprotective effect of sesamol, a constituent of sesame oil, has been examined in the uvb-(280-320nm) irradiated human blood lymphocytes. lymphocytes pretreated with increasing concentrations of sesamol (1, 5 and 10++g/ml) for 30min, were irradiated and lipid peroxidation and antioxidant defense were examined. uvb-irradiated lymphocytes exhibited increased levels of li ...200521783559
the frequency of food allergy in australia and asia.a review of the development of food allergy in a birth cohort of 620 australian infants at high risk for development of atopic disease has recently been completed. extrapolating to a random community population showed that at the age of two, egg appears the most frequent food allergen (3.2%), while cow milk (2.0%), and peanut are of similar frequency (1.9%). the prevalence of hypersensitivity to wheat and soy appears similar to sesame seed, cashew nut, hazelnut and walnut, but allergy to fish, b ...199721781807
amended safety assessment of sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate.sesamum indicum (sesame) seed oil and related cosmetic ingredients are derived from sesamum indicum. sesamum indicum (sesame) seed oil, sesamum indicum (sesame) oil unsaponifiables, and hydrogenated sesame seed oil function as conditioning agents. sodium sesameseedate functions as a cleansing agent, emulsifying agent, and a nonaqueous viscosity increasing agent. these ingredients are neither skin irritants, sensitizers, teratogens, nor carcinogens at exposures that would result from cosmetic use ...201121772026
impact of applying edible oils to silk channels on ear pests of sweet corn.the impact of applying edible oils to corn silks on ear-feeding insects in sweet corn, zea mays l., production was evaluated in 2006 and 2007. six edible oils used in this experiment were canola, corn, olive, peanut, sesame, and soybean. water and two commercial insecticidal oils (neemix neem oil and nc21 sunspray ultrafine, a horticultural mineral oil) were used as the controls for the experiment. six parameters evaluated in this experiment were corn earworm [helicoverpa zea (boddie) (lepidopte ...201121735916
neonatal injections of methoxychlor decrease adult rat female reproductive behavior.methoxychlor (mxc), a commonly used pesticide, has been labeled as an endocrine disruptor. to evaluate the impact of neonatal exposure to mxc on female reproduction, female sprague-dawley rats were given subcutaneous injections on postnatal days 1, 3, and 5. the injections contained 1.0mg mxc, 2.0mg mxc, 10++g 17+¦-estradiol benzoate (positive control), or sesame oil (vehicle). the injections of mxc had no effect on anogenital distance or day of vaginal opening. treatment with either 2.0mg mxc o ...201121726579
estradiol suppresses recovery of rem sleep following sleep deprivation in ovariectomized female rats.sleep complaints such as insufficient sleep and insomnia are twice as prevalent in women. symptoms of sleep disruption are often coincident with changes in the gonadal hormone profile across a women's lifespan. data from a number of different species, including humans, non-human primates and rodents strongly implicate a role for gonadal hormones in the modulation of sleep. in female rats, increased levels of circulating estradiol increase wakefulness and reduce sleep in the dark phase. in this s ...201121722658
bactericidal activity identified in 2s albumin from sesame seeds and in silico studies of structure-function relations.pathogenic bacteria constitute an important cause of hospital-acquired infections. however, the misuse of available bactericidal agents has led to the appearance of antibiotic-resistant strains. thus, efforts to seek new antimicrobials with different action mechanisms would have an enormous impact. here, a novel antimicrobial protein (siamp2) belonging to the 2s albumin family was isolated from sesamum indicum kernels and evaluated against several bacteria and fungi. furthermore, in silico analy ...201121691771
renal phenotype in mice lacking the kir5.1 (kcnj16) k+ channel subunit contrasts with that observed in sesame/east syndrome.the heteromeric inwardly rectifying kir4.1/kir5.1 k(+) channel underlies the basolateral k(+) conductance in the distal nephron and is extremely sensitive to inhibition by intracellular ph. the functional importance of kir4.1/kir5.1 in renal ion transport has recently been highlighted by mutations in the human kir4.1 gene (kcnj10) that result in seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (sesame)/epilepsy, ataxia, sensorineural deafness, and renal tub ...201121633011
elevated corticosterone levels during the first postpartum period influence subsequent pregnancy outcomes and behaviours of the dam.postpartum depression affects 15% of new mothers and previous depressive episodes increases the risk for postpartum depression. chronic administration of corticosterone (cort) to dams during the postpartum period causes depressive-like behaviour and has been used as a model of postpartum depression. to better understand the subsequent progress of this model we examined whether there were persistent effects of cort treatment during the dam's first postpartum period on maternal care and mood follo ...201121623960
sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of mapk and cox-2 activation.abstract: background: kainic acid (ka)-induced status epilepticus (se) was involved with release of free radicals. sesamin is a well-known antioxidant from sesame seeds and it scavenges free radicals in several brain injury models. however the neuroprotective mechanism of sesamin to ka-induced seizure has not been studied. methods: rodents (male fvb mice and sprague-dawley rats) were fed with sesamin extract (90% of sesamin and 10% sesamolin), 15 mg/kg or 30 mg/kg, for 3 days before ka subcutane ...201121609430
experimental gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research.the aminoglycoside antibiotic gentamicin (gm) is still widely used against infections by gram-positive and gram-negative aerobic bacteria. its therapeutic efficacy, however, is limited by renal impairment that occurs in up to 30% of treated patients. the drug may accumulate in epithelial tubular cells causing a range of effects starting with loss of the brush border in epithelial cells and ending in overt tubular necrosis, activation of apoptosis and massive proteolysis. gm also causes cell deat ...201121599835
accumulation of cu, zn, pb, and cd in edible parts of four commonly grown crops in two contaminated soils.soil heavy metal pollution resulting from human activities is causing major concern due to its potential risk. in this study, four crop species with different cultivars were planted in 2 levels (heavily and slightly) of heavy metal contaminated soils, and the accumulation of cu, zn, pb, and cd in the edible parts of the crops were investigated. metal concentrations in sesame seeds grown in both soils exceeded both the chinese food hygiene standard (cfhs) and codex alimentarius commission standar ...201121598793
experimental antithrombotic effects of sesame seed whole grains and extracts.prevention of arterial thrombotic diseases has a high priority in developed countries. an inappropriate diet is known to enhance the risks for acute thrombotic events, and nutritional products experimentally shown to be antithrombotic, might contribute beneficial effects. the present study forms part of a series of investigations into the antithrombotic effect of various foods and vegetables. roasted and crushed whole grains from six varieties of sesame seeds were added to the diet of mice. anti ...201121577091
open sesame: activating dormant replication origins in the mouse immunoglobulin heavy chain (igh) locus.chromosomal dna replication in mammals initiates from replication origins whose activity differs in accordance with cell type and differentiation state. in addition to origins that are active in unperturbed conditions, chromosomes also contain dormant origins that can become functional in response to certain genotoxic stress conditions. improper regulation of origin usage can cause genomic instability leading to tumorigenesis. we review findings from recent single-molecule dna fiber studies exam ...201121571518
the mechanism of sesame oil in ameliorating experimental autoimmune encephalomyelitis in c57bl/6 mice.experimental autoimmune encephalomyelitis (eae) is a th1 cell-mediated autoimmune disease of the cns that serves as an animal model for multiple sclerosis (ms). the study investigated the effectiveness of treatment with sesame oil on the development of eae. eae was induced in 8 week old c57bl/6 mice with an emulsion of mog35-55. therapy with sesame oil (4 ml/kg/day as oral gavage) was started on day 3 before the immunization. ifn-gamma and il-10 production from cultured spleen supernatants were ...201121538630
a kinetic study on sesame cake protein hydrolysis by alcalase.in the present study, the hydrolysis of sesame cake protein was performed by alcalase, a bacterial protease produced by bacillus licheniformis, to investigate the reaction kinetics of sesame cake hydrolysis and to determine decay and product inhibition effects for alcalase. the reactions were carried out for 10 min in 0.1 l of aqueous solutions containing 10, 15, 20, 25, and 30 g protein/l at various temperature and ph values. to determine decay and product inhibition effects for alcalase, a ser ...201121535655
antihyperlipidemic effect of sesame (sesamum indicum l.) protein isolate in rats fed a normal and high cholesterol diet.the dietary influence of sesame protein isolate (protein content 91.5%), produced from dehulled, defatted sesame meal, on blood and tissue lipid profile and lipid peroxidation has been assessed in normal and hypercholesterolemic rats. to evaluate their hypocholesterolemic and antioxidative activity in vivo, we fed 18% sesame protein isolate with or without 2% cholesterol in comparison with casein to rats for 28 d. we determined plasma total protein, total cholesterol, high-density lipoprotein (h ...201021535600
bisphenol-a (bpa) affects reproductive formation across generations in mice.to understand effects of bisphenol-a (bpa) exposure on the reproductive organ across generations, we analyzed morphology of the uterus and ovary, and the methylation pattern of hoxa10 gene of the 2nd generation. pregnant mice (f0) were treated with sc injection of bpa in sesame oil at various doses of 0-1000 mg/kg bwt on days 12-16 of gestation. their offspring (f1) were bred by foster mice, and the offspring (f2) from f1 mice were prepared. that is, f1 mice experienced in utero bpa exposure dur ...201121532259
mechanism of oil-pulling therapy -in vitro study.background: oil pulling has been used extensively as a traditional indian folk remedy without scientific proof for many years for strengthening teeth, gums and jaws and to prevent decay, oral malodor, bleeding gums and dryness of throat and cracked lips. aim: the aim of this study was to evaluate the antibacterial activity of sesame oil and lignans isolated from sesame oil on oral microorganisms and to check whether saponification or emulsification occurs during oil-pulling therapy. materials an ...201121525674
sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of epha1 and ephb2.receptor tyrosine kinase ephb2 and autophagic machinery are known as tumor suppressors; however, the connection remains to be elucidated. here, we show the link between ephb2 and autophagy. sesamin, a major lignan in sesame oil, induced autophagy in the human colon cancer cell lines ht29 and ls180, as shown by electron microscopy, as well as western blotting and immunofluorescence imaging using an anti-lc3 antibody. receptor tyrosine kinase array analysis revealed that sesamin treatment increase ...201121503576
neurological assessments after treatment with the antimalarial β-arteether in neonatal and adult rats.the world health organization currently recommends combinatorial treatment including artemisinins as first-line therapy against drug-resistant plasmodium falciparum malaria. although highly efficacious, artemisinin and its derivatives, including β-arteether (βae), are associated with ototoxicity, tremors, and other autonomic and motor impairments in the clinic. similar neurological symptoms, as well as brainstem lesions, have been observed in adult laboratory species (mice, rats, dogs, and non h ...201121477617
dietary polyunsaturated fatty acid prevents hyperlipidemia and hepatic oxidant status in pregnant diabetic rats and their macrosomic offspring.a considerable amount of clinical and experimental evidence now exists and suggests the involvement of fatty acids and free radical-mediated oxidative processes in the pathogenesis of diabetic complications. fetuses from diabetic mothers are at increased risk of developing neonatal macrosomia and oxidative stress. we investigated the modulation of antioxidant status and liver biochemical parameters in normal and diabetic pregnant rats and their offspring. animals were randomly allocated into thr ...201121458299
meloxicam carbopol-based gels: characterization and evaluation.purpose: to formulate and evaluate the hydrogels containing meloxicam for topical application and also compare the effect of penetration enhancers on release of drug. methods: meloxicam gels were prepared by dispersion method using carbopol-940 and 934 (1%w/w) as rate controlling polymer and drug penetration enhancers such as tween 80, oleic acid and sesame oil in the concentration of 1% and 2% . the formulated gels were evaluated for drug content, ph, viscosity, spreadability, extrudability, in ...201121453256
[preparation method of stalk environmental biomaterial and its sorption ability for polycyclic aromatic hydrocarbons in water].the soybean, sesame and corn stalks were pyrolyzed and charred for 8 h at 300-700 degrees c to obtain stalk environmental biomaterials. the bet specific surface areas, methylene blue, and iodine adsorption capacity of the stalk environmental biomaterials were determined. the sorption efficiency of these materials on single polycyclic aromatic hydrocarbon (pah) and mixing pahs were investigated. the bet specific surface areas of stalk biomaterials enlarged, and the sorption ability on methylene b ...201121404677
sesame oil prevents acute kidney injury induced by the synergistic action of aminoglycoside and iodinated contrast in rats.the aim of the study was to investigate the effect of sesame oil on acute kidney injury induced by the synergistic action of aminoglycoside and iodinated contrast in rats. acute kidney injury was induced by a 5-day course of daily gentamicin injections (100 mg/kg of body weight, subcutaneously) and then iodinated contrast (4 ml/kg, intravenously) in male specific-pathogen-free sprague-dawley rats. sesame oil (0.5 ml/kg, orally) was given 1 h before iodinated contrast. renal function and oxidativ ...201121402854
stress-induced alterations in anxiety-like behavior and adaptations in plasticity in the bed nucleus of the stria terminalis.in vulnerable individuals, exposure to stressors can result in chronic disorders such as generalized anxiety disorder (gad), major depressive disorder (mdd), and post-traumatic stress disorder (ptsd). the extended amygdala is critically implicated in mediating acute and chronic stress responsivity and anxiety-like behaviors. the bed nucleus of the stria terminalis (bnst), a subregion of the extended amygdala, serves as a relay of corticolimbic information to the paraventricular nucleus of the hy ...201121396387
intestinal distribution and excretion of sesaminol and its tetrahydrofuranoid metabolites in rats.sesame seeds (sesamum indicum l.) are unique because of potent and various physiological activities imparted by their bioactive lignans. this investigation studied the intestinal distribution and excretion of sesaminol in sprague-dawley (sd) rats. to investigate the distribution of sesaminol (per oral 220 mg/kg), the changes in concentration of sesaminol and its metabolites were determined in the intestines and plasma within the 24 h period after tube feeding of sesaminol to sd rats. results sho ...201121384919
prevalence of challenge-proven ige-mediated food allergy using population-based sampling and predetermined challenge criteria in infants.several indicators suggest that food allergy in infants is common and possibly increasing. few studies have used oral food challenge to measure this phenomenon at the population level.201121377036
neurological assessments after treatment with the antimalarial ß-arteether in neonatal and adult rats.the world health organization currently recommends combinatorial treatment including artemisinins as first-line therapy against drug-resistant plasmodium falciparum malaria. although highly efficacious, artemisinin and its derivatives, including ß-arteether (ßae), are associated with ototoxicity, tremors, and other autonomic and motor impairments in the clinic. similar neurological symptoms, as well as brainstem lesions, have been observed in adult laboratory species (mice, rats, dogs, and non h ...201121376079
the mechanism underlying the synergetic hypocholesterolemic effect of sesamin and a-tocopherol in rats fed a high-cholesterol diet.sesamin is a major lignan in sesame seed. we confirmed that ingestion of sesamin and a-tocopherol synergistically reduced the concentration of blood cholesterol in rats given a high-cholesterol diet. to elucidate the molecular mechanism behind this effect, we analyzed the gene-expression profiles in rat liver after co-ingestion of sesamin and a-tocopherol. six-week-old male sprague-dawley rats were fed a 1% cholesterol diet (hc) or hc containing 0.2% sesamin, 1% a-tocopherol or sesamin + a-tocop ...201121372506
p-hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating nrf2, pdi, and neurotrophic factor genes in a rat model of brain ischemia.the therapeutic goal in treating cerebral ischemia is to reduce the extent of brain injury and thus minimize neurological impairment. we examined the effects of p-hydroxybenzyl alcohol (hba), an active component of gastrodia elata blume, on transient focal cerebral ischemia-induced brain injury with respect to the involvement of protein disulphide isomerase (pdi), nuclear factor-e2-related factor 2 (nrf2), and neurotrophic factors. all animals were ovariectomized 14 days before ischemic injury. ...201121347705
involvement of heme oxygenase-1 induction via nrf2/are activation in protection against h2o2-induced pc12 cell death by a metabolite of sesamin contained in sesame seeds.induction of phase ii antioxidant enzymes by activation of nrf2/are (antioxidant response element) signaling has been considered as a promising strategy to combat with oxidative stress-related diseases. in the present study, we tested for potential effects of sesamin, a major lignan contained in sesame seeds, its stereoisomer episesamin, and their metabolites on nrf2/are activation in rat pheochromocytoma pc12 cells. luciferase reporter assays showed that primary metabolites of sesamin and epise ...201121345685
hetereogeneity of dose and time effects of estrogen on neuron-specific neuronal protein and phosphorylated cyclic amp response element-binding protein in the hippocampus of ovariectomized rats.previous studies have shown changes in the cyclic amp response element-binding protein (creb) signaling pathway in ca1 and ca3 regions of the rostral hippocampus with 10 µg estrogen treatment for 14 days. it appears that estrogen's action on creb phosphorylation in brain structures depends on other estrogen doses and lengths of treatment. we therefore examined the effects of moderate regimens [2.5 µg estradiol benzoate (eb) for 4 or 14 days] on mean numbers of neuron-specific neuronal protein (n ...201121337376
mutations in the melanocortin 1 receptor, ß-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in akita-inu dogs.to identify factors that control coat color in akita-inu dogs, we sequenced all the exons of the melanocortin 1 receptor (mc1r), ß-defensin103 (cbd103) and agouti signaling protein (asip) genes of dogs with four distinct coat colors, namely, brindle, sesame, red and white. then we examined correlations among specific alleles and coat color. in the case of the mc1r gene, all white dogs were homozygous for a nonsense mutation, r306ter, while brindle, sesame, and red dogs had at least one r306 alle ...201121321476
protective effects of sesame oil on 4-nqo-induced oxidative dna damage and lipid peroxidation in rats.sesame oil could be considered as a potent antioxidant and dietary supplement. it possesses antimutagenic, anti-inflammatory and anti-cardiac toxicity. in the view of available findings, the current study focused on determining the protective effects of sesame oil on 4-nitroquinoline-1-oxide (4-nqo) -induced oxidative dna damage and lipid peroxidation (lpo) in rats. seven groups of wistar albino rats each with 6 either sex were used. groups were given vehicle control and sesame oil alone orally ...201121314461
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