Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| low-grade lymphomas in young homosexual men without lav/htlv iii infection. | 1986 | 2877052 | |
| use of the rapid-ana system to screen for enzyme activities that differ among species of bile-inhibited bacteroides. | the rapid-ana system (innovative diagnostics systems, inc., atlanta, ga.) was used to test 102 strains of 14 species of phenotypically similar bile-inhibited bacteroides from humans. bacteroides oris, bacteroides veroralis, bacteroides buccalis, bacteroides melaninogenicus, bacteroides loescheii, and bacteroides denticola had very similar enzyme activity profiles. clear differentiation of these six species by the rapid-ana system was not possible, but tests for arginine aminopeptidase and beta-g ... | 1986 | 2871042 |
| energetics and mechanics of contracting white myotomal fibres from dogfish, scyliorhinus canicula. | 1989 | 2798483 | |
| energetics and mechanics of contracting white myotomal fibres from dogfish, scyliorhinus canicula. | 1989 | 2798483 | |
| levels of adult alcohol consumption induced by interactions with child confederates exhibiting normal versus externalizing behaviors. | investigated levels of distress and alcohol consumption in ss interacting with problematic vs non-problematic child confederates. social drinkers were randomly assigned to interact with boys trained to enact behaviors characteristic of either normal or attention-deficit disorder/conduct disorder (add/cd) children. mood data were collected before and after the interaction. ss engaged in ad lib beer consumption for 20 min, while anticipating another interaction with the same boy. children in the a ... | 2009 | 2768665 |
| a high density in vitro extracellular electrode array: description and implementation. | the detailed activation sequence in myocardium provides information critical to the understanding of the mechanisms of cardiac arrhythmias and the influence of interventions. despite the pivotal role of activation mapping, the interpretation of isochronic maps and the correlation to detailed tissue morphology may be limited when the interelectrode distances are large with respect to cell dimensions. additionally, dynamic beat-to-beat variations in the activation pattern or the effect of interven ... | 2009 | 2764148 |
| development of personality and intelligence in children with congenital heart disease. | one hundred and twenty-eight children with congenital heart disease (chd) and 89 healthy controls were compared according to their development of personality and intelligence. presence of physical disability in daily life was the independent variable for dividing children with chd into two groups: children with physical handicap due to chd (n = 77) have lower iq scores than healthy children. unexpectedly, in the parents' opinion they show no difference in behaviour patterns. on introspective exa ... | 2009 | 2708467 |
| a century of change in neurosurgery at johns hopkins: 1889-1989. | neurosurgical admissions to the johns hopkins hospital during the first year of its existence, the first and last years of harvey cushing's practice, the last years of walter dandy's practice, the last years of earl walker's tenure, and the current neurosurgical case load are reviewed. sixteen patients with neurosurgical problems were admitted during the first year of the hospital's existence. in the first year of harvey cushing's staff appointment, 38 neurosurgical patients were admitted. infec ... | 2009 | 2681565 |
| immunomodulatory effects of bacteroides products on in vitro human lymphocyte functions. | bacteroides spp. have been implicated in the pathogenesis of several diseases, including periodontal diseases. in this study sonic extracts of 6 bacteroides spp. were examined for their abilities to alter human lymphocyte function. we found that soluble extracts from bacteroides intermedius, bacteroides endodontalis, bacteroides asaccharolyticus, bacteroides melaninogenicus, and to a lesser degree bacteroides loescheii, caused dose-dependent inhibition of human lymphocyte responsiveness to both ... | 1989 | 2628864 |
| further studies on the degradation of immunoglobulins by black-pigmented bacteroides. | the ability of several species of black-pigmented bacteroides to degrade immunoglobulins a and g was confirmed in this study. the cleavage products from igg strongly stimulated the growth of bacteria degrading igg. growth of bacteroides gingivalis on limiting media supplemented with igg paralleled growth on complete medium. the degradation of igg and iga by black-pigmented bacteroides appeared to occur in 2 stages. the molecules were broken into large fragments which were subsequently degraded i ... | 1989 | 2628862 |
| fifty hours for the poor? | 2008 | 2612144 | |
| prevalence of black-pigmented bacteroides species in root canal infections. | the prevalence of black-pigmented bacteroides species in the root canals of 72 teeth with apical periodontitis was evaluated. twenty-two of the canals contained one or more species of black-pigmented bacteroides. bacteroides intermedius (14 strains) and bacteroides endodontalis (5 strains) were most common. of the species bacteroides gingivalis, bacteroides loeschei, and bacteroides denticola, 2, 3, and 1 strains, respectively, were isolated. the median number of bacterial cells recovered from t ... | 1989 | 2607261 |
| bacteroides loeschei pk1295 cells express two distinct adhesins simultaneously. | bacteroides loeschei synthesizes two distinct adhesins that mediate its coaggregation with streptococcus sanguis 34 and actinomyces israeli pk14. streptococcal adhesin-specific and actinomyces adhesin-specific monoclonal antibodies were used to prepare antibody-coated 5- or 10-nm gold particles. these were used in immunoelectron microscopic studies to establish that essentially all bacteroides cells in a population express both adhesins. in general, the two sizes of gold particles representing e ... | 1989 | 2572563 |
| fimbria-associated adhesin of bacteroides loeschei that recognizes receptors on procaryotic and eucaryotic cells. | inhibition studies with a set of adhesin-specific monoclonal antibodies and various sugars revealed that a fimbria-associated adhesin of bacteroides loeschei recognizes receptors on both procaryotic and eucaryotic cells. these interactions permit this bacterium to attach to both types of cells, producing coaggregates in the presence of strains of streptococcus sanguis and hemagglutination in the presence of neuraminidase-treated human erythrocytes. | 1989 | 2569449 |
| [purification and some properties of neuraminidase from the culture medium of bacteroides loescheii atcc 15930]. | the purpose of this study is to investigate the mechanism on enhanced hemagglutination caused by neuraminidase from bacteroides in an aspect of zeta-potential levels on erythrocytes and inhibitors on hemagglutination activity. the neuraminidase from the culture medium of bacteroides loescheii atcc 15930 was purified by ultrafiltration followed by deae-sephacel anion exchange chromatography, fast protein, polypeptide, polynucleotide, liquid chromatography using mono p column and finally high perf ... | 1989 | 2488923 |
| colonoscopic surveillance in long-standing total ulcerative colitis--a 15-year follow-up study. | in a 15-year surveillance program composed of 72 patients with total ulcerative colitis, 12 patients developed definite dysplasia. at endoscopy, low-grade dysplasia was detected in seven patients, high-grade in four, and a carcinoma (dukes' stage a at operation) in one. one of the patients with high-grade dysplasia and macroscopical lesions at colonoscopy had a carcinoma (dukes' a) detected at operation. a sequential development of dysplasia was found in seven patients. the cumulative risk of de ... | 2003 | 2394325 |
| meningitis resource pack (the meningitis trust 1989) | 2007 | 2223203 | |
| the incidence of periodontopathic microorganisms in young children. | thirty-six children in 4 cohorts of 0-1 week, 1-6 months, 1-2 years and 2-2 1/2 years of age were examined for the presence of black-pigmented bacteroides species and some other bacteria suspected of being involved in the subsequent development of periodontal destruction. none of the sought-after bacteria were detected in the first week of life. bacteroides intermedius and bacteroides melaninogenicus were detected as early as 1 month after birth. both of these bacteria were detected in 16-37% of ... | 1990 | 2087345 |
| the formation of hydrogen sulfide and methyl mercaptan by oral bacteria. | the capacity to form volatile sulfur compounds was tested in bacteria isolated from subgingival microbiotas and in a representative number of reference strains. a majority of the 75 tested oral bacterial species and 7 unnamed bacterial taxa formed significant amounts of hydrogen sulfide from l-cysteine. the most active bacteria were found in the genera peptostreptococcus, eubacterium, selenomonas, centipeda, bacteroides and fusobacterium. methyl mercaptan from l-methionine was formed by some mem ... | 1990 | 2082242 |
| reduced incidence of bone metastases in irradiated areas after external radiation therapy of prostatic carcinoma. | fourteen males, out of 380 patients, treated with radiation to the central pelvis and lumbar spine for poorly differentiated prostatic carcinoma were analyzed in retrospect. the dose of radiation to the bones of the target area was 5,000 cgy. the patients showed no signs of metastases at bone scintigraphy performed in connection with the treatment. in an average of 34 months after finishing radiotherapy, the patients developed metastases at bone scintigraphy. the pattern was similar in all patie ... | 2007 | 2045303 |
| purification and characterization of a bacteroides loeschei adhesin that interacts with procaryotic and eucaryotic cells. | the adhesin of bacteroides loeschei pk1295 that mediates coaggregation with streptococcus sanguis 34 and hemagglutination of erythrocytes was purified to electrophoretic homogeneity. the lectinlike protein has an estimated native mr of 450,000 and consists of six subunits of identical molecular weight (mr 75,000). the purified adhesin appears to be a basic protein with a pi between 7.4 and 8.0. amino acid and n-terminal sequence analyses were carried out with the purified protein. these indicate ... | 1990 | 1970562 |
| major salivary gland lymphoepithelial lesions and the acquired immunodeficiency syndrome. | presently, there is no consensus regarding the most appropriate diagnostic and therapeutic approach to patients with human immunodeficiency virus (hiv)-associated lymphoepithelial lesions of the major salivary glands. a retrospective review of 60 consecutive patients with lymphoepithelial lesions is presented. thirty-eight cases were associated with hiv infection. lesions associated with hiv infection were usually bilateral, multiple, cystic, and associated with lymphadenopathy. in contrast, in ... | 1991 | 1951883 |
| purification and properties of neuraminidase from the culture medium of bacteroides loescheii. | neuraminidase was purified from the culture medium of bacteroides loescheii atcc 15930 by ultrafiltration followed by a deae-sephacel anion exchange chromatography, fast-protein liquid chromatography using mono p column and high-performance liquid chromatography using a shim-pack diol-300 column. the molecular weight of the purified enzyme was measured to be approximately 87 kda and the optimal ph was at 4.8. although the enzyme was able to hydrolyze the substrates with alpha,2-3, alpha,2-6, and ... | 1991 | 1820573 |
| rapid presumptive identification of black-pigmented gram-negative anaerobic bacteria by using 4-methylumbelliferone derivatives. | a rapid method for presumptive identification of black-pigmented gram-negative anaerobic rods was developed. using filter paper spot tests for indole production, sialidase, alpha-glucosidase, beta-glucosidase, alpha-fucosidase, and trypsinlike enzyme activities, 100% of porphyromonas gingivalis, prevotella intermedia, and bacteroides levii and 89% of prevotella corporis isolates were correctly identified to the species level. porphyromonas asaccharolytica and porphyromonas endodontalis could not ... | 1991 | 1774320 |
| degradation of native human hemoglobin following hemolysis by prevotella loescheii. | prevotella loescheii pk1295 can grow on native hemoglobin as a source of heme. supernatants of p. loescheii cultures hemolysed human erythrocytes and degraded native hemoglobin. these combined activities may provide heme (or iron) for the growth of p. loescheii and other dental plaque bacteria. | 1992 | 1548099 |
| the early colonization of gram-negative anaerobic bacteria in edentulous infants. | the occurrence of oral gram-negative anaerobes was examined in 30 edentulous infants (mean age 3 months, range 1-7 months). one pooled swab sample from mucosal surfaces (cheeks, palate, tongue) and one saliva sample was taken from each infant. the samples were cultured aerobically and anaerobically using non-selective and selective media. prevotella (bacteroides) melaninogenica was the most frequently isolated anaerobe, found in 70% of the infants. the other common anaerobes were fusobacterium n ... | 1992 | 1528621 |
| relationship between oral gram-negative anaerobic bacteria in saliva of the mother and the colonization of her edentulous infant. | various gram-negative anaerobic bacterial species can be detected in the oral flora of edentulous infants. however, knowledge of the initial infection source is still scarce. thirty caucasian mothers (mean age 30 years) and their edentulous infants (mean age 3 months) were examined for the possible similarity of the oral gram-negative anaerobic flora. paraffin-stimulated saliva was collected from the mothers. a pooled swab sample from mucosal surfaces and unstimulated saliva were collected from ... | 1992 | 1494450 |
| probability estimation for biomedical classification problems. | suppose that we wish to know the probability that an object belongs to a class. for example, we may wish to estimate the probability that a patient has a particular disease, given a set of symptoms, or we may wish to know the probability that a novel peptide binds to a receptor, given the peptide's amino-acid composition. the conventional approach is to first use a classification algorithm to find partitions in feature space and to assign each partition to a class, and then to estimate the condi ... | 2006 | 1482915 |
| doppler investigation of uteroplacental blood flow resistance in the second trimester: a screening study for pre-eclampsia and intrauterine growth retardation. | 2006 | 1472202 | |
| the gene encoding a prevotella loescheii lectin-like adhesin contains an interrupted sequence which causes a frameshift. | we cloned and sequenced the prevotella loescheii gene plaa, which encodes a lectin-like adhesin that mediates the coaggregation of p. loescheii 1295 with streptococcus oralis 34. a probe derived from the n-terminal amino acid sequence of the purified adhesin was used to identify the plaa gene from a p. loescheii genomic library constructed in lambda gem-11. sequence analysis of plaa indicates that the initial translation product contains a 22-amino-acid leader. the reading frame of the plaa gene ... | 1992 | 1429455 |
| mandatory testing? | 2006 | 1426457 | |
| suppressive effect of soluble factor(s) derived from prevotella loescheii atcc 15930 on proliferation of human lymphocytes. | soluble sonic extracts of prevotella loescheii caused a dose-dependent inhibition of human peripheral blood lymphocyte proliferation by mitogen and of the proliferation of a leukemic cell line, ball-1, when assessed by dna synthesis (3h-thymidine incorporation). rna (3h-uridine incorporation) and protein (3h-leucine incorporation) synthesis were similarly altered after exposure to the extract. there was no effect on cell viability as measured by either trypan blue exclusion or extracellular rele ... | 1992 | 1408357 |
| emended descriptions of prevotella denticola, prevotella loescheii, prevotella veroralis, and prevotella melaninogenica. | during studies of human periodontal disease, a number of bacterial strains were encountered that, on the basis of results of standard biochemical tests, appeared to be prevotella buccalis, prevotella denticola, prevotella melaninogenica, or prevotella loescheii. however, use of the standard biochemical tests, cellular fatty acid analyses, and the polyacrylamide gel electrophoresis patterns of soluble proteins resulted in conflicting identifications of these strains. the results of tests for cell ... | 1992 | 1390106 |
| detubularization-induced contractile response change of the ileum following ileocystoplasty. | we reported previously that following ileocystoplasty the structure and pharmacologic response of the implanted ileum changes towards that of the bladder. specifically, the relaxation response to alpha adrenergic (methoxamine) and purinergic (atp) stimulation reverses to a contractile response one month after the ileal segment is surgically made part of the urinary bladder. the present study was designed to investigate possible signals for this change and also to determine whether bladder respon ... | 1992 | 1351953 |
| gene cloning of porphyromonas gingivalis specific antigens recognized by serum of adult periodontitis patient. | 1. porphyromonas gingivalis is believed an important pathogen of adult periodontitis. a gene library of p. gingivalis 381 was constructed in lambda phage vector l47.1. the library was probed with serum obtained from patients of severe adult periodontitis. two clones, lambda mdbg101 and lambda mdbg103 which were expressed, 200 and 160 kda respectively, were selected and further studied. 2. the expressed antigens in these two clones were also reacted with rabbit antiserum against whole cells, caps ... | 1992 | 1319357 |
| carcinoma of the male breast following thymic irradiation. | a white male teenager with carcinoma of the breast had received radiation therapy for an asymptomatic enlarged thymus on the second, fourth and seventh days of life. the dose delivered to the infant breasts, the latent period, and the unusually young age of the patient suggest that the malignancy was related to the course of radiotherapy. | 2005 | 1153746 |
| antiinflammatory beta-arylamidoacrylic acids. | a series of 34 beta-arylamidoacrylic acids was prepared and examined for antiinflammatory activity. these compounds are vinylogous carbamic acids, and several displayed activity equal to phenylbutazone in the rat pleural effusion model. highest activity was associated with structures bearing halogen and cyano substituents. amides were inactive. | 1975 | 1151961 |
| racial distribution of alpha1-antitrypsin variants among junior high school students. | a survey of alpha1-antitrypsin phenotypes and serum trypsin inhibitory capacities was performed in 1,841 seventh grade junior high school students. antitrypsin deficiency states were detected only in white subjects (3.04) per cent) and not in 461 subjects of other races or of mexican origin. a screening level of serum trypsin inhibitory capacity at 75 per cent of normal or less included all of the deficient phenotypes, but phenotyping was necessary to eliminate a small percentage of normal and u ... | 2005 | 1087540 |
| [eeg-activity patterns in visual information processing: characteristics, variance-analytical deliminiation, discriminance-analytical determination of undispensable variables and scale level]. | 1. in order to determine the variable distributions of 5 activation dependent eeg activity patterns occurring during visual information processing, mean values and standard deviations of the percental quantities of the frequencies 4, 5, ..., 13 hz, 14 to 20 hz and 21 to 30 hz, as well as the mean amplitudes in the frequency bands 3.5 ... 7.4 hz, 7.5 ... 13.4 hz and 13.5 to 30 hz were determined on corresponding to 10 s samples. it could be demonstrated by regression analysis that an interval sca ... | 2004 | 525137 |
| interactions of folch-lees proteolipid apoprotein with planar lipid bilayers. | water-soluble folch-lees proteolipid apoprotein from bovine cns white matter induces a voltage-dependent conductance in black lipid membranes. na+ is required for the induced conductance change but the established conductance has very low ionic selectivity. the induced conductance fluctuates with a minimum amplitude of 10(-11)--10(-10) mho. the magnitude of the conductivity change is dependent on protein concentration and on the composition of lipid bilayers. at a fixed voltage the induced condu ... | 1979 | 522128 |
| word-processing equipment for hospital pharmacy applications. | experiences with the use of three word-processing machines in the pharmacy departments of two hospitals are reported. criteria used in evaluating the equipment included keyboard design, disc storage capabilities, software practicality, print format options and security of data. the applications studied were label production, storage of personnel information, scheduling of repetitive tasks, and composition of drug bulletins and procedure manuals. the wang system 10a was the least useful. the lani ... | 2004 | 517539 |
| grey-scale ultrasonic characteristics of carcinoma of the pancreas. | fifty-five sonograms were performed on 25 cases of surgically and histologically proven carcinoma of the pancreas. the sonographic appearances of the tumour were determined. a diffuse echogenic pattern with irregular margin was the most common appearance. displacement and indentation of the inferior vena cava and superior mesenteric vessels, greatly assist in localizing the tumour to the pancreas. a reliable prediction of tumour size and resectability cannot be determined by sonography alone. so ... | 2004 | 444820 |
| planning and evaluation: the roles of the public and voluntary sectors. | 1984 | 263260 | |
| emergency care: assist. | 1988 | 259259 | |
| [health by the people]. | 1992 | 257057 | |
| you really are underpaid. | 2003 | 254307 | |
| blocking action of ruthenium red on cholinergic and non-cholinergic synapses: possible involvment of sialic acid-containing substrates in neurotransmission. | 1988 | 210881 | |
| altered activity of hepatic mixed-function mono-oxygenase enzymes in streptozotocin-induced diabetic rats. | 1. in streptozotocin-induced diabetic male rats, hepatic microsomal aminopyrine n-demethylase activity was depressed, whereas aniline hydroxylase activity and cytochrome p-450 content were increased over control values. 2. in diabetic female rats, hepatic microsomal aminopyrine n-demethylase activity, aniline hydroxylase activity, biphenyl 4-hydroxylase activity, and cytochrome p-450 content were increased over control values. 3. insulin treatment of diabetic male and female rats antagonized all ... | 1978 | 152519 |
| a new device to support handicapped patients during venography or myelography. | the authors describe a seating device which holds the patient in position when the x-ray table is tilted and permits non-weight-bearing venograms to be obtained in handicapped as well as normal patients. simultaneous bilateral venography reduces the study time considerably. the device is also helpful in lumbar myelography in paraplegics. | 2003 | 149336 |
| congenital postural deformities. | 2002 | 130955 | |
| cricopharyngeal sphincterotomy and bilateral division of the chorda tympani in bulbar palsy. | 2002 | 128757 | |
| rectus sheath haematoma. | 2002 | 127923 | |
| the possible role of tightly bound adenine nucleotides in oxidative and photosynthetic phosphorylation. | the tightly bound nucleotides of the beff-heart mitochondrial atpase are released during cold inactivation followed by ammonium sulfate precipitation. during incubation at 0 degrees c the sedimentation coefficient (s20w) of the atpase first declines from 12.1s to 9s. prolonged incubation or precipitation with ammonium sulfate leads to dissociation of the 9s component into subunits with s20w of 3.5s. the 9s component still bears bound nucleotides which exchange more extensively and rapidly with a ... | 1975 | 127089 |
| letter: bromide intoxication. | 2002 | 126712 | |
| [complications in laparoscopic interventions and how to prevent them]. | 1998 | 124827 | |
| validating audit criteria: an analytic approach illustrated by peptic ulcer disease. | 1998 | 121383 | |
| [clinical observations with a preparation with a base of 4-isobutylphenyl-2-propionate of lysine in degenerative rheumatic diseases]. | 2002 | 120797 | |
| properties of the bacillus subtilis spore coat. | about 70% of the protein in isolated bacillus subtilis spore coats was solubilized by treatment with a combination of reducing and denaturing agents at alkaline ph. the residue, consisting primarily of protein, was insoluble in a variety of reagents. the soluble proteins were resolved into at least seven bands by sodium dodecyl sulfate gel electrophoresis. about one-half of the total was four proteins of 8,000 to 12,000 daltons. these were relatively tyrosine rich, and one was a glycoprotein. th ... | 1979 | 108242 |
| [effect of polychlorinated biphenyls in the rat: ii.--preliminary report on metabolic alterations (author's transl)]. | rats were fed with a diet containing 10 and 100 ppm (wet weight) of phenoclor dpr for 4 weeks in order to evaluate the toxicity of a french pcb mixture. the influence of pcb was studied by determining the liver weights, the hepatic and muscular proteins, glycogen and humidity content as well as hematocrite, glucose, proteins and lipids in the plasma, and the lipidic contents of the liver and the carcass. there was a significant increase in both liver to body weight ratios and liver lipid and pro ... | 1978 | 105425 |
| quantitation of particles in the freeze-fractured nuclear membrane after renal ischemia. | changes in the number and sizes of membrane-associated particles have been quantitated in the protoplasmic (p) and exoplasmic (e) fracture faces of the outer membrane of nuclei isolated from the inner cortex following renal ischemia and reflow in the rat. no changes were observed in the inner nuclear membrane. after 20-min ischemia, the number of particles in both fracture faces decreased. with reflow, the total number of particles decreased after both 20- and 60-min ischemia. the partition coef ... | 1978 | 98907 |
| frankly speaking: economics: nursing's friend or foe? | 1999 | 96934 | |
| an evaluation of surgical and conservative treatment of fractures of the ankle in 200 patients. | the longterm results of surgical and conservative treatment in two almost identical groups of patients with fractures of the ankle have been analyzed. the results were better after conservative treatment; delayed operation and repeated manipulations were found to be the main reason for the poorer postoperative results, especially in elderly osteoporotic patients. the damage consequent to repeated manipulations, the difficulties resulting from delaying operation, and the advantages of early open ... | 1999 | 96272 |
| the results of randomised and other clinical trials of fast neutrons from the medical research council cyclotron, london. | 2001 | 96057 | |
| beta-lactamase inhibitors--a novel approach. | 1999 | 89565 | |
| hermann zondek. | 1999 | 89329 | |
| [nuclear surface of buccal cells as a function of the nature of the stain. measurements with an image analyzing computer]. | measure of nuclear areas was performed on buccal smears by the quantimet 720 image analysing computer. five different staining procedures were used and we consider that toluidin blue at ph 4 is the best for a fine quantitative caryometry. | 2001 | 88973 |
| fatal leishmaniasis in renal-transport patient. | 1999 | 88649 | |
| [intratypical antigenic differentiation of poliovirus strains circulating in mali by means of cross-adsorbed sera]. | the intratypic antigenic differentiation of poliovirus strains isolated from sick or healthy children in mali in 1975-1976 was performed. the method is based on the use of cross-adsorbed sera in the neutralization tests in which the virus is titrated by the plaque procedure or by the cytopathic effect. all the examined strains of serologic types i, ii, and iii were distinguished by the antigenic structure from the vaccine strains and were classified as "wild". quantitative differences in the ant ... | 1978 | 86237 |
| localization of nors in chromosomes of mouse cell lines by a combined 33258-hoechst and ag-staining technique. | 1979 | 84805 |