Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| abnormal brain connectivity spectrum disorders following thimerosal administration: a prospective longitudinal case-control assessment of medical records in the vaccine safety datalink. | autism spectrum disorder (asd), tic disorder (td), and hyperkinetic syndrome of childhood (attention deficit disorder [add]/attention deficit hyperactivity disorder [adhd]) are disorders recently defined as abnormal connectivity spectrum disorders (acsds) because they show a similar pattern of abnormal brain connectivity. this study examines whether these disorders are associated with exposure to thimerosal, a mercury (hg)-based preservative. | 2017 | 28539852 |
| nontypeable haemophilus influenzae and chronic obstructive pulmonary disease: a review for clinicians. | chronic obstructive pulmonary disease (copd) is a leading cause of morbidity and mortality worldwide. in the lower airways of copd patients, bacterial infection is a common phenomenon and haemophilus influenzae is the most commonly identified bacteria. haemophilus influenzae is divided into typeable and nontypeable (nthi) strains based on the presence or absence of a polysaccharide capsule. while nthi is a common commensal in the human nasopharynx, it is associated with considerable inflammation ... | 2017 | 28539074 |
| bronchial inflammation and bacterial load in stable copd is associated with tlr4 overexpression. | toll-like receptors (tlrs) and nucleotide-binding oligomerisation domain (nod)-like receptors (nlrs) are two major forms of innate immune sensors but their role in the immunopathology of stable chronic obstructive pulmonary disease (copd) is incompletely studied. our objective here was to investigate tlr and nlr signalling pathways in the bronchial mucosa in stable copd.using immunohistochemistry, the expression levels of tlr2, tlr4, tlr9, nod1, nod2, cd14, myeloid differentiation primary respon ... | 2017 | 28536249 |
| lot-to-lot consistency, safety and immunogenicity of 3 lots of haemophilus influenzae type b conjugate vaccine: results from a phase iii randomized, multicenter study in infants. | vaccination against haemophilus influenzae type b (hib) is included in routine pediatric immunization schedule in the united states. previous vaccine shortages have created the need for additional options for hib vaccination. | 2017 | 28536030 |
| live attenuated tetravalent (g1-g4) bovine-human reassortant rotavirus vaccine (brv-tv): randomized, controlled phase iii study in indian infants. | rotavirus remains the leading cause of diarrhoea among children <5years. we assessed immunogenic non-inferiority of a tetravalent bovine-human reassortant rotavirus vaccine (brv-tv) over the licensed human-bovine pentavalent rotavirus vaccine rv5. | 2017 | 28536027 |
| budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by thp-1 macrophages and respiratory pathogens during macrophage infection. | patients with more severe chronic obstructive pulmonary disease frequently experience exacerbations and it is estimated that up to 50% of these exacerbations are associated with bacterial infections. the mainstay treatment for these infection-related exacerbations constitutes the administration of glucocorticoids, alone or in combination with antibiotics. a recent line of evidence demonstrates that many hormones including the steroid beclomethasone can also directly affect bacterial growth, viru ... | 2017 | 28528362 |
| the sensor study: protocol for a mixed-methods study of self-management checks to predict exacerbations of pseudomonas aeruginosa in patients with long-term respiratory conditions. | there are an estimated three million people in the united kingdom with chronic obstructive pulmonary disease (copd), and the incidence of bronchiectasis is estimated at around 0.1% but is more common in copd and severe asthma. both copd and bronchiectasis are characterized by exacerbations in which bacteria play a central role. pseudomonas aeruginosa is isolated from sputum samples from 4% to 15% of adults with copd and is more likely to be isolated from patients with severe disease. earlier det ... | 2017 | 28526665 |
| respiratory viral infections are underdiagnosed in patients with suspected sepsis. | the study aim was to investigate the prevalence and clinical relevance of viral findings by multiplex pcr from the nasopharynx of clinically septic patients during a winter season. during 11 weeks of the influenza epidemic period in january-march 2012, consecutive adult patients suspected to be septic (n = 432) were analyzed with cultures from blood and nasopharynx plus multiplex pcr for respiratory viruses on the nasopharyngeal specimen. the results were compared with those from microbiology an ... | 2017 | 28516200 |
| epidemiology of paediatric meningitis in central côte d'ivoire after the implementation of haemophilus influenzae type b vaccination. | infectious meningitis accounts for enormous morbidity worldwide, but there is a paucity of data on its regional epidemiology in resource-constrained settings of sub-saharan africa. here, we present a study on the aetiology of paediatric meningitis in central côte d'ivoire. between june 2012 and december 2013, all cerebrospinal fluid (csf) samples drawn at the university teaching hospital bouaké were examined for the presence of bacterial and fungal pathogens. a causative agent was detected in 31 ... | 2017 | 28513815 |
| flagellar expression in clinical isolates of non-typeable haemophilus influenzae. | haemophilus influenzae is a commensal organism found in the upper respiratory tract of humans. when h. influenzae becomes a pathogen, these bacteria can move out of their commensal niche and cause multiple respiratory tract diseases such as otitis media, sinusitis, conjunctivitis and bronchitis in children, and chronic obstructive pulmonary disease in adults. however, h. influenzae is currently considered a non-flagellate bacterium. | 2017 | 28513418 |
| multiple drug resistance in haemophilus influenzae isolated from patients in bangkok, thailand. | 2017 | 28506825 | |
| haemophilus influenzae type b meningitis: is there a re-emergence? 24 years of experience in a children's hospital. | haemophilus influenzae type b (hib) used to be the main cause of bacterial meningitis in children younger than 5 years old. following the introduction of the hib vaccine in the immunization schedule (1998), its incidence reduced significantly but it has increased over the last years. the objectives of this study included describing the characteristics and analyzing the epidemic curve of haemophilus influenzae type b (hib) meningitis by comparing the pre- and postimmunization periods. | 2017 | 28504487 |
| the asplenic patient: post-insult immunocompetence, infection, and vaccination. | splenic injury can occur through multiple mechanisms and may result in various degrees of residual immunocompetence. functionally or anatomically asplenic patients are at higher risk for infection, particularly with encapsulated bacteria. vaccination is recommended to prevent infection with these organisms; however, the recommendations are routinely updated, and vaccine selection and timing are complex. | 2017 | 28498097 |
| development of immunochromatographic colloidal gold test strip for rapid detection of haemophilus influenzae in clinical specimens. | a simple and fast test strip for simultaneous detection of haemophilus influenzae, based on the theory of colloidal gold immunochromatography was developed. | 2017 | 28497596 |
| bacteria isolated from the airways of paediatric patients with bronchiectasis according to hiv status. | knowledge of which bacteria are found in the airways of paediatric patients with bronchiectasis unrelated to cystic fibrosis (cf) is important in defining empirical antibiotic guidelines for the treatment of acute infective exacerbations. | 2017 | 28492126 |
| curcumin inhibits nthi-induced muc5ac mucin overproduction in otitis media via upregulation of mapk phosphatase mkp-1. | otitis media (om), characterized by the presence of mucus overproduction and excess inflammation in the middle ear, is the most common childhood infection. nontypeable haemophilus influenzae (nthi) pathogen is responsible for approximately one-third of episodes of bacteria-caused om. current treatments for bacterial om rely on the systemic use of antibiotics, which often leads to the emergence of multidrug resistant bacterial strains. therefore there is an urgent need for developing alternative ... | 2017 | 28487811 |
| polysaccharide conjugate vaccine protein carriers as a "neglected valency" - potential and limitations. | the development of vaccines against polysaccharide-encapsulated pathogens (e.g. haemophilus influenzae type b, pneumococci, meningococci) is challenging because polysaccharides do not elicit a strong and long-lasting immune response (i.e. t-cell independent). this can be overcome by conjugating the polysaccharide to a protein carrier (e.g. tetanus toxoid, cross-reacting material 197 [crm]), which vastly improves the immune response and induces memory to the polysaccharide (t-cell dependent). alt ... | 2017 | 28487056 |
| investigations of a possible chemical effect of salvadora persica chewing sticks. | salvadora persica is commonly used chewing sticks in many parts of the world as an oral hygiene tool. this study measured the amount of benzyl isothiocyanate (bitc) released into the mouth and assessed its retention time in saliva. the study also tested if the released amount of bitc could potentially be antibacterial or cytotoxic. twelve subjects brushed their teeth with fresh miswak once, twice, and four times. the amount of bitc in the saliva and in the used brushes was quantified using gas c ... | 2017 | 28484501 |
| surveillance of the activity of solithromycin (cem-101) against bacteria from respiratory tract infections. | the activity of solithromycin, a fourth-generation macrolide and novel fluoroketolide, was evaluated by determining its minimum inhibitory concentration (mic) (via clinical and laboratory standards institute broth microdilution) against 2797 contemporary clinical respiratory tract isolates collected from north america, europe, asia-pacific and other regions of the world in 2012-13. solithromycin was very active against streptococcus pneumoniae and streptococcus pyogenes, with mic90 of 0.25 and 0 ... | 2017 | 28483717 |
| infectious complications of pediatric cochlear implants are highly influenced by otitis media. | determine the incidence of ear infections in cochlear implant patients, evaluate the contribution of otitis media to complications, describe the bacteriology of otitis media in the cochlear implant population, the treatment provided at our center, and the long term outcome. | 2017 | 28483256 |
| monophosphoryl lipid a enhances nontypeable haemophilus influenzae-specific mucosal and systemic immune responses by intranasal immunization. | acute otitis media (aom) is one of the most common infectious diseases in children. nontypeable haemophilus influenzae (nthi) is gram-negative bacteria that are considered major pathogens of aom and respiratory tract infections. in this study, we used monophosphoryl lipid a (mpl), a toll-like receptor (tlr) 4 agonist, as an adjuvant to induce mucosal immune responses against nthi to enhance bacterial clearance from the nasopharynx. | 2017 | 28483250 |
| mucosal and systemic immune response to sublingual or intranasal immunization with phosphorylcholine. | phosphorylcholine (pc) is a structural component of a wide variety of pathogens including streptococcus pneumoniae and haemophilus influenzae. here, the immune response in mice to pc immunization via the sublingual (sl) route versus the intranasal (in) route was investigated in terms of efficacy and safety. | 2017 | 28478921 |
| cost-effectiveness analysis of vaccinations and decision makings on vaccination programmes in hong kong: a systematic review. | to describe and systematically review the modelling and reporting of cost-effectiveness analysis of vaccination in hong kong, and to identify areas for quality enhancement in future cost-effectiveness analyses. | 2017 | 28476628 |
| individual preferences for child and adolescent vaccine attributes: a systematic review of the stated preference literature. | discrete choice experiments are increasingly used to assess preferences for vaccines and vaccine service delivery. | 2017 | 28474295 |
| serotype changes and antimicrobial nonsusceptibility rates of invasive and non-invasive streptococcus pneumoniae isolates after implementation of 10-valent pneumococcal nontypeable haemophilus influenzae protein d conjugate vaccine (phid-cv) in bulgaria. | the 10-valent pneumococcal conjugate vaccine (pcv10) has been included in bulgarian childhood immunization program since 2010. this study aimed to assess serotype distribution and antimicrobial resistance of 198 invasive and non-invasive streptococcus pneumoniae strains that had been isolated in bulgaria during 2011-2016 from patients with invasive (ipd) and non-invasive (nipd) pneumococcal diseases. the most common invasive serotypes were 3 (10.1%), 19f (4.0%), and 7f (3.0%). a significant decr ... | 2017 | 28472614 |
| epidemiology of nasopharyngeal carriage by haemophilus influenzae in healthy children: a study in the mediterranean coast region. | haemophilus influenzae (hi), a colonizer of the nasopharynx in children causes mainly otitis and sinusitis. the primary objective of this study was to determine the prevalence of pharyngeal colonization by hi, and the secondary objectives were to identify risk factors associated with hi colonization and its antibiotic susceptibility. | 2017 | 28472007 |
| effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among greenlandic children. | in 2010, greenland introduced the 13-valent pneumococcal conjugate vaccine (prevnar 13®- pcv-13) in the childhood immunisation program. the authors aimed to evaluate the impact of pcv-13 on nasopharyngeal carriage of bacteria frequently associated with respiratory infections in children. | 2017 | 28467237 |
| occult bacteremia: should we look for the needle in the haystack? | once a well-recognized entity, occult bacteremia (ob) is no longer a significant or serious bacterial infection. first following the introduction of the haemophilus influenzae type b vaccine and now with the implementation of the conjugate pneumococcal vaccine (pcv), the number of cases has declined significantly. this has led to a change in many published guidelines to avoid taking blood cultures in fully vaccinated children presenting with fever. in israel, the introduction of the pcv13 is now ... | 2016 | 28466611 |
| recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link? | dispersal of bacteria from a biofilm in the middle ear, serving as a bacterial reservoir, could explain the recurrent and chronic nature of chronic suppurative otitis media (csom). the objective of this study is to investigate if the same strains of bacteria could be detected in repeated episodes of otorrhea in csom. in a prospective case series at a primary healthcare clinic in nuuk, greenland, patients with more than 14 days of otorrhea were included consecutively. samples for culturing and bi ... | 2017 | 28466356 |
| utilizing pharmacy intervention in asplenic patients to improve vaccination rates. | asplenic patients are at increased risk for post-splenectomy infection caused by streptococcus pneumoniae, neisseria meningitidis, and haemophilus influenzae type b (hib), and vaccination rates against these organisms remain low. the purpose of this study was to evaluate vaccination rates before and after implementation of a pharmacist-driven electronic vaccination tracking system. | 2017 | 28464987 |
| pediatric bacterial meningitis in japan, 2013-2015 - 3-5 years after the wide use of haemophilus influenzae type b and streptococcus pneumoniae conjugated vaccines. | haemophilus influenzae type b (hib) vaccine and pneumococcal conjugated vaccine (pcv) have been widely used since 2010 in japan when both vaccines were supported by the regional governments, and they were covered as routine recommended vaccines in 2013. the incidence of bacterial meningitis due to these organisms decreased in 2011 and 2012, but meningitis due to streptococcus agalactiae and escherichia coli remained unchanged. | 2017 | 28456490 |
| role of neural barriers in the pathogenesis and outcome of streptococcus pneumoniae meningitis. | bacterial meningitis is an inflammatory disease of the meninges of the central nervous system (cns). streptococcus pneumoniae (s. pneumoniae), neisseria meningitidis, and haemophilus influenzae are the major bacterial pathogens causing meningitis with s. pneumoniae being responsible for two thirds of meningitis cases in the developed world. to reach the cns following nasopharyngeal colonization and bacteraemia, the bacteria traverse from the circulation across the blood brain barrier (bbb) and c ... | 2017 | 28450902 |
| complete genome sequence of bordetella pertussis pelita iii, the production strain for an indonesian whole-cell pertussis vaccine. | pt bio farma, the sole world health organization-approved indonesian vaccine producer, manufactures a whole-cell whooping cough vaccine (wp) that, as part of a pentavalent diphtheria-tetanus-pertussis/hepatitis b/haemophilus influenzae b (dtp/hb/hib) vaccine, is used in indonesia and many other countries. we report here the whole-genome sequence for bordetella pertussis pelita iii, pt bio farma's wp production strain. | 2017 | 28450511 |
| effect of prophylactic or therapeutic administration of paracetamol on immune response to dtwp-hepb-hib combination vaccine in indian infants. | vaccination is considered as the most cost effective method for preventing infectious diseases. low grade fever is a known adverse effect of vaccination. in india, it is a common clinical practice to prescribe paracetamol either prophylactically or therapeutically to manage fever. some studies have shown that paracetamol interferes with antibody responses following immunization. this manuscript reports the outcome of a post hoc analysis of data from a clinical trial of a pentavalent vaccine in i ... | 2017 | 28449972 |
| insights on persistent airway infection by non-typeable haemophilus influenzae in chronic obstructive pulmonary disease. | non-typeable haemophilus influenzae (nthi) is the most common bacterial cause of infection of the lower airways in adults with chronic obstructive pulmonary disease (copd). infection of the copd airways causes acute exacerbations, resulting in substantial morbidity and mortality. nthi has evolved multiple mechanisms to establish infection in the hostile environment of the copd airways, allowing the pathogen to persist in the airways for months to years. persistent infection of the copd airways c ... | 2017 | 28449098 |
| effects of n-acetyl-l-cysteine on the membrane vesicle release and growth of respiratory pathogens. | bacterial infections contribute to the disease progression of chronic obstructive pulmonary disease by stimulating mucus production in the airways. this increased mucus production and other symptoms are often alleviated when patients are treated with mucolytics such as n-acetyl-l-cysteine (nac). moreover, nac has been suggested to inhibit bacterial growth. bacteria can release membrane vesicles (mvs) in response to stress, and recent studies report a role for these proinflammatory mvs in the pat ... | 2017 | 28444395 |
| correction: relationships between mucosal antibodies, non-typeable haemophilus influenzae (nthi) infection and airway inflammation in copd. | [this corrects the article doi: 10.1371/journal.pone.0167250.]. | 2017 | 28441440 |
| antibiogram profile of septic meningitis among children in duhok, iraq. | to determine the prevalence of bacteria in the cerebrospinal fluid (csf), and the antibiogram profile in pediatric patients with suspected meningitis. methods: this descriptive study was conducted between january 2014 and january 2016 in the hevi paediatric teaching hospital in duhok, iraq. the csf samples were withdrawn from 432 pediatric patients suspected of meningitis. the samples were cultured, and antibiotic sensitivity tests were performed. results: there were 33 (7.6%) culture positive ... | 2017 | 28439602 |
| a prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in copd. | the aetiology of acute exacerbations of copd (aecopd) is incompletely understood. understanding the relationship between chronic bacterial airway infection and viral exposure may explain the incidence and seasonality of these events. | 2017 | 28432209 |
| etiological analysis and epidemiological comparison among adult cap and nhcap patients in okinawa, japan. | etiological epidemiology and diagnosis are important issues for cap and nhcap. despite the availability of effective therapies, significant morbidity and mortality ensues. | 2017 | 28431934 |
| childhood vaccinations and risk of acute lymphoblastic leukaemia in children. | it has been proposed that childhood vaccinations protect against acute lymphoblastic leukaemia (all) in children by modulation of future responses to common infections in childhood. however, the available studies provide inconsistent findings, and population-based cohort studies with longitudinal information on vaccinations are lacking. | 2017 | 28431124 |
| antimicrobial susceptibility of bacterial isolates from patients presenting with ear, nose and throat (ent) infections in the german community healthcare setting. | empiric initial antibiotic therapy of bacterial infections is based primarily upon the susceptibility of the most common causative pathogens. the purpose of this study was to provide susceptibility data on six bacterial species known to cause ear, nose and throat (ent) infections. a total of 1066 isolates collected during a nationwide laboratory-based surveillance study were analysed. all streptococcus pyogenes isolates were penicillin (pen)-susceptible, indicating that natural penicillins can s ... | 2017 | 28429163 |
| invasive haemophilus influenzae infections in children in kamikawa subprefecture, hokkaido, japan, 2006-2015: the effectiveness of h. influenzae type b vaccine. | we evaluated 24 children with invasive haemophilus influenzae infections between 2006 and 2015 in kamikawa subprefecture of hokkaido, japan. the most frequent disease was pneumonia in 12 cases (50.0%), followed by meningitis in 7 (29.2%) and bacteremia in 5 (20.8%). patients ranged in age from 3 months to 12 years of age. seventeen (70.8%) of the total were less than 2 years old. the incidence rate of h. influenzae infection varied from 15.1 to 36.3 per 100,000 population in the kamikawa area du ... | 2017 | 28427992 |
| factors affecting sound energy absorbance in acute otitis media model of chinchilla. | acute otitis media (aom) is a rapid-onset infection of the middle ear which results in middle ear pressure (mep), middle ear effusion (mee), and structural changes in middle ear tissues. previous studies from our laboratory have identified that mep, mee, and middle ear structural changes are three factors affecting tympanic membrane (tm) mobility and hearing levels (guan et al., 2014, 2013). sound energy reflectance or absorbance (ea) is a diagnostic tool increasingly used in clinical settings f ... | 2017 | 28426992 |
| immunization with 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv) according to different schedules in infants in south africa: a phase iii trial. | limited clinical data exists to assess differences between various infant pneumococcal conjugate vaccine schedules. in this trial, we evaluated immunogenicity of the 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv) administered using 3 different immunization schedules in hiv unexposed-uninfected infants in south africa. | 2017 | 28425818 |
| typing and characterization of bacteria using bottom-up tandem mass spectrometry proteomics. | methods for rapid and reliable microbial identification are essential in modern healthcare. the ability to detect and correctly identify pathogenic species and their resistance phenotype is necessary for accurate diagnosis and efficient treatment of infectious diseases. bottom-up tandem mass spectrometry (ms) proteomics enables rapid characterization of large parts of the expressed genes of microorganisms. however, the generated data are highly fragmented, making downstream analyses complex. her ... | 2017 | 28420677 |
| performance evaluation of a newly developed and fully automated bacteriological analyzer "raisus any" for antimicrobial susceptibility testing of fastidious bacteria haemophilus influenzae and streptococcus pneumoniae. | antimicrobial susceptibility testing for fastidious bacteria, such as haemophilus influenzae (h. influenzae) and streptococcus pneumoniae (s. pneumoniae) has been performed manually. we evaluated the performance of a newly developed fully automated system for rapid bacterial identification and antimicrobial susceptibility testing "raisus any" (nissui pharmaceutical co., ltd.). | 2017 | 28413870 |
| nasopharyngeal polymicrobial colonization during health, viral upper respiratory infection and upper respiratory bacterial infection. | we sought to understand how polymicrobial colonization varies during health, viral upper respiratory infection (uri) and acute upper respiratory bacterial infection to understand differences in infection-prone vs. non-prone patients. | 2017 | 28412081 |
| bacterial and histopathological findings in deep head and neck infections: a retrospective analysis. | deep neck infections are among the most dangerous acute diseases in the head and neck region. this analysis gives an overview of the bacterial and histopathologic findings of deep neck infections. | 2017 | 28411005 |
| active offer of vaccinations during hospitalization improves coverage among splenectomized patients: an italian experience. | in 2014, an italian hospital implemented a protocol for pneumococcal, meningococcal, and haemophilus influenzae type b vaccines offer to splenectomized patients during their hospitalization. after 1 year, coverage for recommended vaccinations increased from 5.7%-66.7% and the average time between splenectomy and vaccines administration decreased from 84.7-7.5 days. | 2017 | 28410825 |
| comment on: emergence and molecular characterization of haemophilus influenzae harbouring mef(a). | 2017 | 28407074 | |
| emergence and molecular characterization of haemophilus influenzae harbouring mef(a)-authors' response. | 2017 | 28407066 | |
| evaluation of a taqman array card for detection of central nervous system infections. | infections of the central nervous system (cns) are often acute, with significant morbidity and mortality. routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-saharan africa. we developed a taqman array card (tac) that detects multiple pathogens simultaneously from cerebrospinal fluid. the 21-pathogen cns multiple-pathogen tac (cns-tac) assay includes two parasites (ba ... | 2017 | 28404679 |
| parasitic infections in pregnancy decrease placental transfer of antipneumococcus antibodies. | many factors can influence maternal placental antibody transfer to the fetus, which confers important immune protection to the newborn infant. however, little is known about the effect of maternal parasitic infection on placental antibody transfer. to investigate this, we selected from a parent study of 576 pregnant kenyan women four groups of women with term deliveries (≥37 weeks), including uninfected women (n = 30) and women with solo infections with malaria (n = 30), hookworm (n = 30), or sc ... | 2017 | 28404574 |
| immunogenicity and safety of 10-valent pneumococcal nontypeable haemophilus influenzae protein d conjugate vaccine (phid-cv) administered to children with sickle cell disease between 8 weeks and 2 years of age: a phase iii, open, controlled study. | immunogenicity, safety and reactogenicity of the 10-valent pneumococcal nontypeable haemophilus influenzae protein d conjugate vaccine (phid-cv) were evaluated in children with sickle cell disease (scd), who are at increased risk for infections. | 2017 | 28403055 |
| ceftaroline activity tested against bacterial isolates causing community-acquired respiratory tract infections and skin and skin structure infections in pediatric patients from united states hospitals: 2012-2014. | ceftaroline fosamil has recently received us food and drug administration approval for treatment of acute bacterial skin/skin structure infections (sssis), including those caused by methicillin-resistant staphylococcus aureus and community-acquired bacterial pneumonia for pediatric patients ≥2 months old. we evaluated the potency and spectrum of ceftaroline and comparators when tested against community-acquired respiratory tract infection (carti) and sssi pathogens from pediatric patients. a tot ... | 2017 | 28403050 |
| sex bias in diagnostic delay in bronchiectasis: an analysis of the spanish historical registry of bronchiectasis. | diagnostic delay is common in most respiratory diseases, particularly in bronchiectasis. however, sex bias in diagnostic delay has not been studied to date. | 2017 | 28393532 |
| a thermostabilized, one-step pcr assay for simultaneous detection of klebsiella pneumoniae and haemophilus influenzae. | klebsiella pneumoniae and haemophilus influenzae are two common pathogens associated with respiratory tract infections. the identification of these pathogens using conventional molecular diagnostic tests requires trained personnel, cold-chain transportation, and storage-dependance, which does not render them user-friendly. the aim of this study was to develop a thermostabilized, cold-chain-free, one-step multiplex pcr for simultaneous detection of k. pneumoniae and h. influenzae. the multiplex p ... | 2017 | 28386286 |
| transcutaneous immunization with a bandaid prevents experimental otitis media in a polymicrobial model. | otitis media (om) is a common pediatric disease and nontypeable haemophilus influenzae (nthi) is the predominant pathogen in chronic om, recurrent om and om associated with treatment failure. om is also a polymicrobial disease, wherein an upper respiratory tract viral infection predisposes to ascension of nthi from the nasopharynx, the site of colonization, to the normally sterile middle ear, resulting in disease. using a clinically relevant viral-bacterial co-infection model of nthi-induced om, ... | 2017 | 28381402 |
| changes in the conjunctival bacterial flora of patients hospitalized in an intensive care unit. | to identify the changes in aerobic conjunctival bacterial flora and to correlate culture results with physical health and the duration of patients' hospitalization in an intensive care unit (icu). | 2017 | 28380097 |
| voluntarily reported immunization registry data: reliability and feasibility to predict immunization rates, san diego, california, 2013. | accurate data on immunization coverage levels are essential to public health program planning. reliability of coverage estimates derived from immunization information systems (iiss) in states where immunization reporting by medical providers is not mandated by the state may be compromised by low rates of participation. to overcome this problem, data on coverage rates are often acquired through random-digit-dial telephone surveys, which require substantial time and resources. this project tested ... | 2017 | 28379785 |
| specific polysaccharide antibody deficiency revealed by severe bacterial infections in adulthood: a report on eleven cases. | we report on 11 cases of specific polysaccharide antibody deficiency (spad) revealed in adulthood by severe infections with encapsulated bacteria. given that immunoglobulin replacement therapy can effectively prevent the recurrence of bacterial infections in this context, spad should be considered once other antibody deficiencies have been ruled out. | 2017 | 28379361 |
| influence of the co-administration of heptavalent conjugate vaccine pcv7-tt on the immunological response elicited by va-mengoc-bc® and heberpenta®-l in rabbits. | finlay vaccine institute is developing a new heptavalent conjugate vaccine against streptococcus pneumoniae. as infants are the target population, pcv7-tt will be necessarily co-administered with other vaccines, and then, the interactions represent a concern. the aim of this work is to evaluate the possible immunological interferences in rabbits as animal experimental model. rabbits were immunized with heberpenta®-l, va-mengoc-bc®, and pcv7-tt. blood samples were taken fourteen days after final ... | 2017 | 28379053 |
| panel 6: vaccines. | objective to review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (om) and (2) development of vaccine antigens for om bacterial and viral pathogens. data sources pubmed database of the national library of science. review methods we performed literature searches in pubmed for om pathogens and candidate vaccine antigens, and we restricted the searches to articles in english that were published between july 2011 and june 2015. panel members review ... | 2017 | 28372533 |
| emergence of invasive haemophilus influenzae type a disease in italy. | we report on the first detection of two cases of invasive haemophilus influenzae type a (hia) disease in italy. the cases were sustained by the same hia "strain" belonging to the st23 clone that has previously been reported only outside europe. the emergence of invasive hia disease is of concern. | 2017 | 28369218 |
| efficacy of 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine against acute otitis media and nasopharyngeal carriage in panamanian children - a randomized controlled trial. | we previously reported 10-valent pneumococcal non-typeable haemophilus influenzae (nthi) protein d conjugate vaccine (phid-cv) efficacy in a double-blind randomized trial (clinicaltrials.gov: nct00466947) against various diseases, including acute otitis media (aom). here, we provide further analyses. in the panamanian subset, 7,359 children were randomized (1:1) to receive phid-cv or control vaccine at age 2/4/6 and 15-18 months. of these, 2,000 had nasopharyngeal swabs collected. aom cases were ... | 2017 | 28368738 |
| first whole-genome sequence of a haemophilus influenzae type e strain isolated from a patient with invasive disease in italy. | in the present era of conjugate vaccines against haemophilus influenzae type b, non-vaccine-preventable strains are of concern. here, we report the first whole-genome sequence of an invasive h. influenzae type e strain. this genomic information will enable further investigations on encapsulated non-type b h. influenzae strains. | 2017 | 28360180 |
| acute bilateral photoreceptor degeneration in an infant after vaccination against measles and rubella. | ocular inflammation is occasionally observed after vaccinations, and most of them resolve without permanent visual disturbances. however, there are some rare cases of severe ocular complications following vaccinations. | 2017 | 28358967 |
| electrostatic repulsion between unique arginine residues is essential for the efficient in vitro assembly of the transmembrane domain of a trimeric autotransporter. | haemophilus influenzae adhesin (hia) belongs to the trimeric autotransporter family and mediates the adherence of these bacteria to the epithelial cells of host organisms. hia contains a passenger and a transmembrane domain. the transmembrane domain forms a 12-stranded β-barrel in which four strands are provided from each subunit. the β-barrel has a pore that is traversed by three α-helices. this domain has a unique arginine cluster, in which the side chains of the three arginine residues locate ... | 2017 | 28357859 |
| next-generation sequencing combined with specific pcr assays to determine the bacterial 16s rrna gene profiles of middle ear fluid collected from children with acute otitis media. | the aim of the study was to analyze the bacteriome of acute otitis media with a novel modification of next-generation sequencing techniques. outpatient children with acute otitis media were enrolled in the study, and middle ear fluids were collected during 90 episodes from 79 subjects aged 5 to 42 months (median age, 19 months). the bacteriome profiles of middle ear fluid samples were determined by a nested-pcr amplification of the 16s rrna gene (v4 region), followed by mass sequencing. the prof ... | 2017 | 28357413 |
| bacterial outer membrane vesicle biogenesis: a new mechanism and its implications. | outer membrane vesicle (omv) release by gram-negative bacteria has been observed and studied for decades. first considered as a by-product of cell lysis, it soon became evident that omvs are actively secreted from the outer membrane (om) of gram-negative bacteria. accordingly, these small particles (~ 10-300 nm in diameter) consist mainly of om components like phospholipids (pls), om proteins, and lipopolysaccharides or lipooligosaccharides. however, omvs may also comprise periplasmic, inner mem ... | 2016 | 28357362 |
| concordance between upper and lower airway microbiota in infants with cystic fibrosis. | nasopharyngeal and oropharyngeal samples are commonly used to direct therapy for lower respiratory tract infections in non-expectorating infants with cystic fibrosis (cf).we aimed to investigate the concordance between the bacterial community compositions of 25 sets of nasopharyngeal, oropharyngeal and bronchoalveolar lavage (bal) samples from 17 infants with cf aged ∼5 months (n=13) and ∼12 months (n=12) using conventional culturing and 16s-rrna sequencing.clustering analyses demonstrated that ... | 2017 | 28356374 |
| molecular characterization and antibiotic susceptibility of haemophilus influenzae clinical isolates. | haemophilus influenzae can cause invasive and severe infections in both adults and children such as otitis media, sinusitis, pneumonia, meningitis and bacteremia. the emerging antibiotic resistance in recent years against ampicillin and several other antibiotics among strains of h. influenzae gives cause for serious concern. here, we investigate ß-lactamase (bl) activity in clinical isolates of h. influenzae, profile their resistance to antibiotics, and characterize the clonal relationship of th ... | 2017 | 28353452 |
| influence of socio-economic inequality measured by the gini coefficient on meningitis incidence caused by mycobacterium tuberculosis and haemophilus influenzae in colombia, 2008-2011. | bacterial meningitis is an important cause of infectious neurological morbidity and mortality. its incidence has decreased with the introduction of vaccination programmes against preventable agents. however, low-income and middle-income countries with poor access to health care still have a significant burden of the disease. thus, the relationship between the gini coefficient and h. influenzae and m. tuberculosis meningitis incidence in colombia, during 2008-2011, was assessed. in this ecologica ... | 2017 | 28353449 |
| haemophilus influenzae pyomyositis in a patient with diabetic ketoacidosis: a unique case and review of literature. | haemophilus influenzae is a gram-negative bacillus commonly known to cause upper respiratory tract infections. skin and soft tissue infections are very uncommon. of these, the majority were associated with necrotizing fasciitis requiring emergent debridement. we report a case of pyomyositis caused by haemophilus influenzae in an adult with diabetes. | 2017 | 28352482 |
| diagnostic value of bronchoalveolar lavage in children with nonresponding community-acquired pneumonia. | community-acquired pneumonia (cap) is a common cause of morbidity and mortality in hospitalized children. in cap, causative agents are seldom identified using noninvasive diagnostic procedures. for those children not responding to empiric antibiotic therapy, it is vital to identify the causative pathogens for further management. | 2017 | 28351556 |
| haemophilus influenzae type a as a cause of paediatric septic arthritis. | incidence rates of invasive haemophilus influenzae serotype b disease have decreased significantly since the introduction of the hib vaccine; however, the rates in indigenous populations remain disproportionately high, specifically in the paediatric population. additionally, with the decline of type b invasive infections, there has been a rebound in the incidence of invasive infections caused by other strains of h. influenzae, particularly serotype a. | 2016 | 28348786 |
| bacterial and viral pathogen spectra of acute respiratory infections in under-5 children in hospital settings in dhaka city. | the study aimed to examine for the first time the spectra of viral and bacterial pathogens along with the antibiotic susceptibility of the isolated bacteria in under-5 children with acute respiratory infections (aris) in hospital settings of dhaka, bangladesh. nasal swabs were collected from 200 under-five children hospitalized with clinical signs of aris. nasal swabs from 30 asymptomatic children were also collected. screening of viral pathogens targeted ten respiratory viruses using rt-qpcr. b ... | 2017 | 28346512 |
| il-17c mediates the recruitment of tumor-associated neutrophils and lung tumor growth. | chronic obstructive pulmonary disease (copd) is associated with an increased risk for lung cancer and an aberrant microbiota of the lung. microbial colonization contributes to chronic neutrophilic inflammation in copd. nontypeable haemophilus influenzae (nthi) is frequently found in lungs of stable copd patients and is the major pathogen triggering exacerbations. the epithelial cytokine interleukin-17c (il-17c) promotes the recruitment of neutrophils into inflamed tissues. the purpose of this st ... | 2017 | 28346430 |
| retrospective report of antimicrobial susceptibility observed in bacterial pathogens isolated from ocular samples at mount sinai hospital, 2010 to 2015. | antimicrobial resistance has emerged as a major threat to global public health. thus, the surveillance of changes in antimicrobial resistance in local and global settings is a paramount necessity. while many studies have tracked antimicrobial resistance, only a small percentage surveyed ocular isolates. the purpose of this study was to report the in vitro susceptibility of bacterial pathogens isolated from ocular samples in new york, ny from 2010 to 2015. | 2017 | 28344783 |
| 50 years ago in the journal of pediatrics: systemic infection with haemophilus influenzae in very young infants. | 2017 | 28343529 | |
| culture of non-typeable haemophilus influenzae from the nasopharynx: not all media are equal. | the efficacy of chocolate agar, versus bacitracin, vancomycin, clindamycin, chocolate agar (bvcca) for the isolation of non-typeable haemophilus influenzae (nthi) from nasopharyngeal swabs was determined. bvcca cultured nthi from 97.3% of nthi-positive swabs, compared to 87.1% for chocolate agar. to maximise culture sensitivity, the use of both media is recommended. | 2017 | 28342745 |
| epidemiological profile and vaccination coverage in splenectomy patients in a health area of murcia (1993-2012). | splenectomy patients have a high risk of suffering severe infections, many of them preventable by vaccination. the aim of the study was to analyse the clinical epidemiological characteristics and vaccine coverage of these patients in health area iii of the region of murcia. | 2017 | 28342711 |
| the role of acute and chronic respiratory colonization and infections in the pathogenesis of copd. | copd is a major global concern, increasingly so in the context of ageing populations. the role of infections in disease pathogenesis and progression is known to be important, yet the mechanisms involved remain to be fully elucidated. while copd pathogens such as haemophilus influenzae, moraxella catarrhalis and streptococcus pneumoniae are strongly associated with acute exacerbations of copd (aecopd), the clinical relevance of these pathogens in stable copd patients remains unclear. immune respo ... | 2017 | 28342288 |
| immunogenicity and safety of primary and booster vaccination with 2 investigational formulations of diphtheria, tetanus and haemophilus influenzae type b antigens in a hexavalent dtpa-hbv-ipv/hib combination vaccine in comparison with the licensed infanrix hexa. | safety and immunogenicity of 2 investigational formulations of diphtheria, tetanus and haemophilus influenzae type b antigens of the combined diphtheria-tetanus-acellular pertussis-hepatitis b-inactivated poliomyelitis-hib vaccine (dtpa-hbv-ipv/hib) were evaluated in a primary (nct01248884) and a booster vaccination (nct01453998) study. in the primary study, 721 healthy infants (randomized 1:1:1) received 3 doses of dtpa-hbv-ipv/hib formulation a (datapa-hbv-ipv/hib), or b (dbtbpa-hbv-ipv/hib) o ... | 2017 | 28340322 |
| draft genome sequences of three nontypeable strains of haemophilus influenzae, c188, r535, and 1200, isolated from different types of disease. | nontypeable haemophilus influenzae is a persistent human respiratory pathogen known to be involved in a range of acute and chronic respiratory diseases. here, we report the genome sequences of three h. influenzae strains isolated from sputum, otitis media, and blood. comparative analyses revealed significant differences in the gene contents including the presence of genes mediating antibiotic resistance. | 2017 | 28336588 |
| throat swabs in children with respiratory tract infection: associations with clinical presentation and potential targets for point-of-care testing. | diagnostic uncertainty over respiratory tract infections (rtis) in primary care contributes to over-prescribing of antibiotics and drives antibiotic resistance. if symptoms and signs predict respiratory tract microbiology, they could help clinicians target antibiotics to bacterial infection. this study aimed to determine relationships between symptoms and signs in children presenting to primary care and microbes from throat swabs. | 2017 | 28334924 |
| analysis of mic and disk diffusion testing variables for gepotidacin and comparator agents against select bacterial pathogens. | this study was conducted to determine the effect of testing parameters on the in vitro activity of gepotidacin, a new triazaacenaphthylene antibacterial agent for the treatment of conventional and biothreat pathogens. clsi methods, and variations of these methods were used to test 10 staphylococcus aureus, 10 streptococcus pneumoniae, 10 haemophilus influenzae, and 5 escherichia coli by mic and 30 s. aureus, 15 s. pneumoniae and 15 s. pyogenes by disk diffusion (dd) methods. levofloxacin and lin ... | 2017 | 28330893 |
| isolation of antimicrobial resistant bacteria in upper respiratory tract infections of patients. | haemophilus influenzae, streptococcus pyogenes, moraxella catarrhalis, staphylococcus aureus, and streptococcus pneumoniae are usual cause of upper respiratory tract infection cases. the present study aims the isolation of bacterial strains which are resistant to the commonly prescribed antibiotics. in total, 900 throat swabs were obtained from the patients suffering from upper respiratory tract infections residing in three different localities. the maximum number of isolates (64 %) were obtaine ... | 2016 | 28330238 |
| erratum: antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable haemophilus influenzae. | 2017 | 28327637 | |
| structure-based function analysis of putative conserved proteins with isomerase activity from haemophilus influenzae. | haemophilus influenzae, a gram-negative bacterium and a member of the family pasteurellaceae, causes chronic bronchitis, bacteremia, meningitis, etc. the h. influenzae is the first organism whose genome was completely sequenced and annotated. here, we have extensively analyzed the genome of h. influenzae using available proteins structure and function analysis tools. the objective of this analysis is to assign a precise function to hypothetical proteins (hps) whose functions are not determined s ... | 2015 | 28324524 |
| in silico study on penicillin derivatives and cephalosporins for upper respiratory tract bacterial pathogens. | upper respiratory tract infection (urti) is an acute infection which involves the upper respiratory tract: nose, sinuses, tonsils and pharynx. urt infections are caused mainly by pathogenic bacteria like streptococcus pneumoniae, haemophilus influenzae and staphylococcus aureus. conventionally, β-lactam antibiotics are used to treat urt infections. penicillin binding proteins (pbps) catalyze the cell wall synthesis in bacteria. β-lactam antibiotics like penicillin, cephalosporins, carbapenems an ... | 2014 | 28324428 |
| structure-based functional annotation of putative conserved proteins having lyase activity from haemophilus influenzae. | haemophilus influenzae is a small pleomorphic gram-negative bacteria which causes several chronic diseases, including bacteremia, meningitis, cellulitis, epiglottitis, septic arthritis, pneumonia, and empyema. here we extensively analyzed the sequenced genome of h. influenzae strain rd kw20 using protein family databases, protein structure prediction, pathways and genome context methods to assign a precise function to proteins whose functions are unknown. these proteins are termed as hypothetica ... | 2015 | 28324295 |
| risk factors for community-acquired bacterial meningitis. | bacterial meningitis is a significant burden of disease and mortality in all age groups worldwide despite the development of effective conjugated vaccines. the pathogenesis of bacterial meningitis is based on complex and incompletely understood host-pathogen interactions. some of these are pathogen-specific, while some are shared between different bacteria. | 2017 | 28301990 |
| hypotonic-hyporesponsive episodes after administration of hexavalent dtp-based combination vaccine: a description of 12 cases. | hypotonic-hyporesponsive (hhe) episodes are known and recognized phenomena, which typically occur within 48 hours of immunisation..our aim is to describe 12 cases of hhe brought to the center of pediatric sleep medicine, with attention to the clinical features of the episode and their follow-up. medical charts of infants visited between 2005-2015 were reviewed. twelve infants showed a hhe using hhe using brighton collaboration criteria. all infants received a hexavalent diphtheria -tetanus -pert ... | 2017 | 28301267 |
| antimicrobial peptide levels are linked to airway inflammation, bacterial colonisation and exacerbations in chronic obstructive pulmonary disease. | antimicrobial peptides (amps) are effectors of host defence against infection, inflammation and wound repair. we aimed to study amp levels in stable chronic obstructive pulmonary disease (copd) and during acute exacerbations of copd (aecopd), and to examine their relation to clinical parameters and inflammatory markers.the 3-year bergen copd cohort study included 433 copd patients and 325 controls. induced sputum was obtained and analysed for levels of the amps human cathelicidin (hcap18/ll-37) ... | 2017 | 28298400 |
| purulent pericarditis as a complication of bacteraemic enterococcus faecalis urinary tract infection. | purulent pericarditis is a rare clinical entity in the modern antibiotic era. the most common portal of entry is thought to be direct extension from a primary lung source and is usually caused by staphylococcus aureus, streptococcus pneumoniae or haemophilus influenzae we report the case of a man aged 69 years who presented with purulent pericarditis due to enterococcus faecalis likely caused by haematogenous spread from a urinary tract source. urgent pericardiocentesis was vital and restored hi ... | 2017 | 28298381 |
| burden and spectrum of bacterial infections among sickle cell disease children living in cameroon. | although sickle cell disease (scd) children are highly susceptible to bacterial infections (bis), there is a dreadful lack of data related to the burden and spectrum of bis in sub-saharan africa (ssa), the highest affected region with scd. this study aimed to determine the burden and spectrum of bis among scd children hospitalized in a pediatric reference hospital in cameroon, a ssa country. | 2017 | 28298206 |
| [postoperative pulmonary disease associated with haemophilus influenzae and neisseria meningitidis in a diabetic child]. | haemophilus influenzae is a saprophyte that colonizes the nasopharynx in nearly two thirds of children and adults. neisseria meningitidis is a strict human bacterium which lives in the nasopharynx. it can cause benign nasopharyngitis or asymptomatic colonization. we report the case of a diabetic child with postoperative pneumonia associated with haemophilus influenzae and neisseria meningitidis. a 3-year old diabetic patient admitted to the department of cardiac surgery due to delayed surgical t ... | 2016 | 28292047 |
| bacteria associated with marginal zone lymphomas. | in the last decades some bacteria have been associated with a various extent with marginal zone (extra nodal, nodal and splenic types) lymphomas are frequently associated with chronic infections, with important clinical, molecular, biological, and therapeutic implications. the well-known correlation between helicobacter pylori and gastric malt-lymphoma, the recently reported links between chlamydia psittaci and ocular adnexal malt-lymphoma and borrelia burgdorferi and cutaneous malt lymphoma con ... | 2017 | 28288714 |