Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [tick-borne infections in denmark]. | the castor bean tick, ixodes ricinus, is common in woodlands in most of denmark. besides borrelia burgdorferi, it can harbour a number of pathogenic microorganisms such as tick-borne encephalitis virus, anaplasma phagocytophilum, rickettsia helvetica, francisella tularensis, candidatus neoehrlichia mikurensis, bartonella spp., borrelia miyamotoi and babesia spp. these tick-borne infections should be a differential diagnostic consideration during the tick season in denmark. we review the distribu ... | 2017 | 28504633 |
| corrigendum to: dna-based identification and ospc serotyping in cultures of borrelia burgdorferi s.l. isolated from ticks collected in the moravia (czech republic). | 2017 | 28504440 | |
| anaplasma phagocytophilum, babesia microti, borrelia burgdorferi sensu lato, and toxoplasma gondii in ixodes ricinus (acari, ixodida) ticks collected from slowinski national park (northern poland). | 2017 | 28504439 | |
| species composition and temporal distribution of adult ixodid ticks and prevalence of borrelia burgdorferi sensu lato and rickettsia species in orange county, california. | 2017 | 28504429 | |
| the clinical relevance of studies on borrelia burgdorferi persisters. | 2017 | 28502813 | |
| western blot techniques. | the western blot is an important laboratory technique that allows for specific identification and characterization of proteins. sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page)-separated proteins are electophoretically transferred to a polyvinylidene fluoride (pvdf) membrane which is then incubated with specific antibodies, then developed to show the protein of interest. here, we describe the transfer and detection of outer surface protein a (ospa), a protein only found on th ... | 2017 | 28501998 |
| prevalence of selected infectious disease agents in stray cats in catalonia, spain. | the objective of the current study was to investigate the prevalence rates of the following infectious agents in 116 stray cats in the barcelona area of spain: anaplasma phagocytophilum, bartonella species, borrelia burgdorferi, chlamydia felis, dirofilaria immitis, ehrlichia species, feline calicivirus (fcv), feline herpesvirus-1 (fhv-1), feline leukaemia virus (felv), feline immunodeficiency virus (fiv), haemoplasmas, mycoplasma species and rickettsia species. | 2017 | 28491415 |
| powassan/deer tick virus and borrelia burgdorferi infection in wisconsin tick populations. | powassan/deer tick virus (powv/dtv) is an emerging cause of arboviral neuroinvasive disease in the upper midwest. these studies describe the prevalence and geographic distribution of wisconsin ticks carrying powv/dtv as well as the high frequency of ixodes scapularis ticks coinfected with both powv/dtv and borrelia burgdorferi, the causative agent of lyme disease. these findings suggest that concurrent transmission of powv/dtv and b. burgdorferi from coinfected ticks is likely to occur in humans ... | 2017 | 28488932 |
| crowdsourcing-based nationwide tick collection reveals the distribution of ixodes ricinus and i. persulcatus and associated pathogens in finland. | a national crowdsourcing-based tick collection campaign was organized in 2015 with the objective of producing novel data on tick distribution and tick-borne pathogens in finland. nearly 20 000 ixodes ticks were collected. the collected material revealed the nationwide distribution of i. persulcatus for the first time and a shift northwards in the distribution of i. ricinus in finland. a subset of 2038 tick samples containing both species was screened for borrelia burgdorferi sensu lato (the prev ... | 2017 | 28487561 |
| every member of the kingdom animalia is a potential vector of human pathogens. | zoonotic diseases are a subset of infectious diseases, which account for enormous morbidity and mortality. pathologies like malaria, rabies, lyme disease, leptospirosis, avian flu etc. are microbe- and parasite-caused ailments, where the etiological agents are introduced into or on the human body via ticks, mosquitoes, birds, rodents, bats, and deer, among other members of kingdom animalia. while some of the zoonotic diseases are well-investigated and caution taken against, a lot many are yet to ... | 2017 | 28487229 |
| identification of tp0751 (pallilysin) as a treponema pallidum vascular adhesin by heterologous expression in the lyme disease spirochete. | treponema pallidum subsp. pallidum, the causative agent of syphilis, is a highly invasive spirochete pathogen that uses the vasculature to disseminate throughout the body. identification of bacterial factors promoting dissemination is crucial for syphilis vaccine development. an important step in dissemination is bacterial adhesion to blood vessel surfaces, a process mediated by bacterial proteins that can withstand forces imposed on adhesive bonds by blood flow (vascular adhesins). the study of ... | 2017 | 28484210 |
| a proteomic signature of dormancy in the actinobacterium micrococcus luteus. | dormancy is a protective state in which diverse bacteria, including mycobacterium tuberculosis, staphylococcus aureus, treponema pallidum (syphilis), and borrelia burgdorferi (lyme disease), curtail metabolic activity to survive external stresses, including antibiotics. evidence suggests dormancy consists of a continuum of interrelated states, including viable but nonculturable (vbnc) and persistence states. vbnc and persistence contribute to antibiotic tolerance, reemergence from latent infecti ... | 2017 | 28484042 |
| when a patient suspected with juvenile idiopathic arthritis turns out to be diagnosed with an infectious disease - a review of lyme arthritis in children. | the lyme arthritis is a common manifestation of infection with borrelia burgdorferi spirochete. despite its infectious background, the inflammation clinically and histopatologically resembles juvenile idiopathic arthritis. as it affects a considerable number of lyme disease patients, it should be routinely considered in differential diagnosis. development of arthritis is partially dependent on spirochetal factors, including the ribosomal spacer type and the sequence of outer surface protein c. i ... | 2017 | 28482848 |
| unusual manifestation of neuroboreliosis (case report). | the paper reported the verified case of neuroboreliosis with unusual clinical presentation of parkinsonism. study aimed at establishing the significance of a precise differential diagnosis with substantial analysis of the symptoms of several diseases to avoid the false diagnosis and to conduct the opportune and adequate therapeutic management. we described the case of the diagnosed neuroboreliosis with clinical expression of multiple sclerosis (ms) and parkinsonism. a 44 years old man was diagno ... | 2017 | 28480854 |
| geographic expansion of lyme disease in michigan, 2000-2014. | most lyme disease cases in the midwestern united states are reported in minnesota and wisconsin. in recent years, however, a widening geographic extent of lyme disease has been noted with evidence of expansion eastwards into michigan and neighboring states with historically low incidence rates. | 2017 | 28480261 |
| identification of a defined linear epitope in the ospa protein of the lyme disease spirochetes that elicits bactericidal antibody responses: implications for vaccine development. | the lipoprotein ospa is produced by the lyme disease spirochetes primarily in unfed ticks. ospa production is down-regulated by the blood meal and it is not produced in mammals except for possible transient production during late stage infection in patients with lyme arthritis. vaccination with ospa elicits antibody (ab) that can target spirochetes in the tick midgut during feeding and inhibit transmission to mammals. ospa was the primary component of the human lymerix™ vaccine. lymerix™ was ava ... | 2017 | 28479174 |
| [usefulness of serological studies for the early diagnosis of lyme disease in primary health care centres]. | the main aim of this study was to determine the usefulness of an early diagnosis of lyme disease (ld) in primary health care centres (phcc) using the elisa test as serological screening technique. | 2017 | 28476293 |
| investigation of ospc expression variation among borrelia burgdorferi strains. | outer surface protein c (ospc) is the most studied major virulence factor of borrelia burgdorferi, the causative agent of lyme disease. the level of ospc varies dramatically among b. burgdorferi strains when cultured in vitro, but little is known about what causes such variation. it has been proposed that the difference in endogenous plasmid contents among strains contribute to variation in ospc phenotype, as b. burgdorferi contains more than 21 endogenous linear (lp) and circular plasmids (cp), ... | 2017 | 28473966 |
| cerebrovascular manifestations of lyme neuroborreliosis-a systematic review of published cases. | lyme neuroborreliosis (lnb) is a disease caused by spirochete borrelia burgdorferi, involving the nervous system. it usually manifests as lymphocytic meningoradiculitis, but in rare cases, it can also lead to cerebrovascular complications. we aimed to perform a systematic review of all reported cases of lnb complicated by central nervous system vasculitis and stroke or transient ischemic attack (tia). | 2017 | 28473801 |
| full-thickness macular hole: a rare complication of borrelia burgdorferi neuroretinitis. | borrelia burgdorferi is a known infective cause of neuroretinitis. we present a case of b burgdorferi neuroretinitis complicated by macular hole in a 22-year-old man. the neuroretinitis was managed with early high-dose intravenous corticosteroid and oral antibiotic. the macular hole was managed with macular hole surgery after intraocular inflammation had resolved. | 2017 | 28473358 |
| [clinical manifestations, diagnosis and treatment of lyme borreliosis]. | lyme borreliosis is an infection caused by the borrelia burgdorferi sensu lato complex and transmitted by ixodes ricinus ticks in denmark. it can manifest itself in several different forms of which erythema migrans is the most common and is diagnosed by clinical assessment of the characteristic erythema. laboratory support for the clinical diagnosis of other manifestations rests on the measurement of borrelia-specific antibodies. treatment is straight-forward with antibiotics such as penicillin. ... | 2017 | 28473022 |
| a bayesian spatio-temporal model for forecasting the prevalence of antibodies to borrelia burgdorferi, causative agent of lyme disease, in domestic dogs within the contiguous united states. | this paper models the prevalence of antibodies to borrelia burgdorferi in domestic dogs in the united states using climate, geographic, and societal factors. we then use this model to forecast the prevalence of antibodies to b. burgdorferi in dogs for 2016. the data available for this study consists of 11,937,925 b. burgdorferi serologic test results collected at the county level within the 48 contiguous united states from 2011-2015. using the serologic data, a baseline b. burgdorferi antibody p ... | 2017 | 28472096 |
| econsultations to infectious disease specialists: questions asked and impact on primary care providers' behavior. | since 2010, the champlain base (building access to specialist advice through econsultation) has allowed primary care providers (pcps) to submit clinical questions to specialists through a secure web service. the study objectives are to describe questions asked to infectious diseases specialists through econsultation and assess impact on physician behaviors. | 2017 | 28470015 |
| canadian rheumatology association meeting, the westin ottawa, ottawa, ontario, canada, february 8-11, 2017. | the 72nd annual meeting of the canadian rheumatology association (cra) was held at the westin ottawa, ottawa, ontario, canada, february 8-11, 2017. the program consisted of presentations covering original research, symposia, awards, and lectures. highlights of the meeting include the following 2017 award winners: dr. vinod chandran, young investigator; dr. jacques p. brown, distinguished investigator; dr. david robinson, teacher-educator; dr. michel zummer, distinguished rheumatologist; ms. rebe ... | 2017 | 28461649 |
| gene sequencing and cases of chronic lyme disease-reply. | 2017 | 28460104 | |
| gene sequencing and cases of chronic lyme disease. | 2017 | 28460095 | |
| primary care physician management of tick bites in the franche-comté region (eastern france, 2013). | tick bites, which may lead to lyme disease, often prompt patients to consult their primary care physicians (pcps). the aim of the present study was to assess how and how often pcps in the franche-comté region of france manage tick bites. | 2017 | 28457701 |
| borrelia burgdorferi-specific iga in lyme disease. | the laboratory diagnosis of lyme disease is currently dependent on the detection of igm and igg antibodies against borrelia burgdorferi, the causative agent of the disease. the significance of serum iga against b. burgdorferi remains unclear. the production of intrathecal iga has been noted in patients with the late lyme disease manifestation, neuroborreliosis, but production of antigen-specific iga during early disease has not been evaluated. in the current study, we assessed serum iga binding ... | 2017 | 28457619 |
| approaches for reverse line blot-based detection of microbial pathogens in ixodes ricinus ticks collected in austria and impact of the chosen method. | ticks transmit a large number of pathogens capable of causing human disease. in this study, the pcr-reverse line blot (rlb) method was used to screen for pathogens in a total of 554 ixodes ricinus ticks collected from all provinces of austria. these pathogens belong to the genera borrelia, rickettsiae, anaplasma/ehrlichia (including "candidatus neoehrlichia"), babesia, and coxiella the pathogens with the highest detected prevalence were spirochetes of the borrelia burgdorferisensu lato complex, ... | 2017 | 28455331 |
| borrelia burgdorferi bbi39 paralogs, targets of protective immunity, reduce pathogen persistence either in hosts or in the vector. | borrelia burgdorferi genome harbors several paralogous gene families (pgf) that can encode immunogenic proteins of unknown function. protein-protein interaction assays using a transmission-blocking vaccine candidate, bba52, as bait identified an interacting partner in spirochetes-a member of pgf 54, annotated as bbi39. we show that bbi39 is a surface-exposed membrane antigen that is immunogenic during spirochete infection, despite the gene being primarily transcribed in the vector with a transie ... | 2017 | 28453837 |
| prevalence and geographic distribution of vector-borne pathogens in apparently healthy dogs in croatia. | vector-borne pathogens (vbps) are a group of globally extended and quickly spreading pathogens that are transmitted by various arthropod vectors. the aim of the present study was to investigate the seroprevalence against babesia canis, anaplasma phagocytophilum, borrelia burgdorferi sensu lato, leishmania infantum, dirofilaria immitis, and ehrlichia canis in dogs in croatia. we investigated 435 randomly selected apparently healthy dogs in 13 different locations of croatia for antibodies to b. ca ... | 2017 | 28448211 |
| isolation of the lyme disease spirochete borrelia mayonii from naturally infected rodents in minnesota. | borrelia mayonii is a newly described member of the borrelia burgdorferi sensu lato complex that is vectored by the black-legged tick (ixodes scapularis say) and a cause of lyme disease in minnesota and wisconsin. vertebrate reservoir hosts involved in the enzootic maintenance of b. mayonii have not yet been identified. here, we describe the first isolation of b. mayonii from naturally infected white-footed mice (peromyscus leucopus rafinesque) and an american red squirrel (tamiasciurus hudsonic ... | 2017 | 28444198 |
| pleomorphism and viability of the lyme disease pathogen borrelia burgdorferi exposed to physiological stress conditions: a correlative cryo-fluorescence and cryo-scanning electron microscopy study. | to understand the response of the lyme disease spirochete borrelia burgdorferi exposed to stress conditions and assess the viability of this spirochete, we used a correlative cryo-fluorescence and cryo-scanning microscopy approach. this approach enables simple exposition of bacteria to various experimental conditions that can be stopped at certain time intervals by cryo-immobilization, examination of cell viability without necessity to maintain suitable culture conditions during viability assays ... | 2017 | 28443079 |
| neuroretinitis as presenting and the only presentation of lyme disease: diagnosis and management. | we present a case of neuroretinitis as presenting and the only presentation of lyme disease in a 25-year-old female who visited hilly areas in the himalayas of north india. she presented with right eye sudden and painless blurring of vision. her vision at presentation was 20/60. she had fundus examination; fundus fluorescein angiography (ffa) and optical coherence tomography (oct) imaging showed classical features of neuroretinitis. no other organ was involved. oral steroids were prescribed and ... | 2017 | 28440258 |
| lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control. | lyme disease is the most common tick-borne disease in temperate regions of north america, europe and asia, and the number of reported cases has increased in many regions as landscapes have been altered. although there has been extensive work on the ecology and epidemiology of this disease in both europe and north america, substantial uncertainty exists about fundamental aspects that determine spatial and temporal variation in both disease risk and human incidence, which hamper effective and effi ... | 2017 | 28438910 |
| detection of anaplasma phagocytophilum, babesia microti, borrelia burgdorferi, borrelia miyamotoi, and powassan virus in ticks by a multiplex real-time reverse transcription-pcr assay. | ixodes scapularis ticks are implicated in transmission of anaplasma phagocytophilum, borrelia burgdorferi, borrelia miyamotoi, babesia microti, and powassan virus. we describe the establishment and implementation of the first multiplex real-time pcr assay with the capability to simultaneously detect and differentiate all five pathogens in a single reaction. the application of this assay for analysis of ticks at sites in new york and connecticut revealed a high prevalence of b. microti in ticks f ... | 2017 | 28435891 |
| application of bayesian decision-making to laboratory testing for lyme disease and comparison with testing for hiv. | in this study, bayes' theorem was used to determine the probability of a patient having lyme disease (ld), given a positive test result obtained using commercial test kits in clinically diagnosed patients. in addition, an algorithm was developed to extend the theorem to the two-tier test methodology. using a disease prevalence of 5%-75% in samples sent for testing by clinicians, evaluated with a c6 peptide enzyme-linked immunosorbent assay (elisa), the probability of infection given a positive t ... | 2017 | 28435311 |
| tick bite and lyme disease-related emergency department encounters in new hampshire, 2010-2014. | lyme disease (ld) is a common tick-borne disease in new hampshire (nh). while ld is a reportable condition and cases are counted for public health surveillance, many more people receive care for tick bites or diagnoses of ld than are reflected in surveillance data. nh's emergency department (ed) data system was queried for tick bite and ld-related encounters. chief complaint text was queried for words related to ld or tick bites. international classification of diseases 9th revision (icd-9) code ... | 2017 | 28432738 |
| dealing with lyme disease treatment. | 2017 | 28431674 | |
| infectious agents is a risk factor for myxomatous mitral valve degeneration: a case control study. | the etiology of myxomatous mitral valve degeneration (mvd) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. the purpose of the study is to analyze the effect of mycoplasma pneumoniae (mp), chlamydophila pneumoniae (cp) and borrelia burgdorferi (bb) on myxomatous mitral valve degeneration pathogenesis and establish whether increased in inflammation and collagen degradation in myxomatous mitral valve deg ... | 2017 | 28431520 |
| a systematic review and meta-analysis for the adverse effects, immunogenicity and efficacy of lyme disease vaccines: guiding novel vaccine development. | lyme borreliosis (lb) is the most prevalent arthropod-borne infectious disease in north america. currently, no vaccine is available to prevent lb in humans, although monovalent and multivalent vaccines have been developed in the past. | 2017 | 28425901 |
| [bilateral facial nerve palsy associated with epstein-barr virus infection in a 3-year-old boy]. | bilateral facial nerve palsy is a rare and sometimes difficult diagnosis. we describe a case of bilateral simultaneous facial nerve palsy associated with epstein-barr virus (ebv) infection in a 3-year-old boy. several symptoms led to the diagnosis of ebv infection: the clinical situation (fever, stomachache, and throat infection), white blood cell count (5300/mm(3) with 70% lymphocyte count), seroconversion with ebv-specific antibodies, lymphocytic meningitis, and a positive blood ebv polymerase ... | 2017 | 28416425 |
| liver microbiome of peromyscus leucopus, a key reservoir host species for emerging infectious diseases in north america. | microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. here we propose a first analysis of the liver microbiome using next generation sequencing as a tool to detect potentially pathogenic strains. we used peromyscus leucopus, the main reservoir host species of lyme disease in eastern north america, as a model and sequenced v5-v6 regions of the 16s gene from 18 populations in southern quebec (canada). the lactobacillus genus was fo ... | 2017 | 28412525 |
| detection of anaplasma spp. and ehrlichia spp. anibodies, and dirofilaria immitis antigens in dogs from seven locations of morocco. | in morocco no data has been published on canine exposure to anaplasma spp., borrrelia burgdorferi, and ehrlichia spp., and only one report is available on the occurrence of dirofilaria immitis in dogs. therefore, the aim of this study was to collect current data on the canine exposure to these vector-borne pathogens (vbps) in morocco. a total of 217 urban (n=57), rural (n=110) and military (n=50) dogs from seven moroccan locations were screened for anaplasma spp., b. burgdorferi and ehrlichia sp ... | 2017 | 28410950 |
| successful treatment of fulminant lyme myocarditis with mechanical circulatory support in a young male adult: a case report. | we describe the case of fulminant myocarditis due to lyme disease and use of mechanical circulatory support (mcs) for the treatment of the lyme carditis associated with refractory cardiogenic shock. fulminant lyme myocarditis in young adult male patient led to a sudden onset of acute, severe biventricular heart failure with progressive cardiogenic shock, and multiorgan failure immediately after admission. | 2017 | 28409501 |
| bilateral facial diplegia: a rare presenting symptom of lyme. | lyme disease is a common disease that is faced by the physician but also acts a mimicker of many other disease processes. facial palsies, especially bilateral, are a relatively rare presenting symptom of lyme disease and may warrant further investigation. a thorough history and physical examination coupled with precision testing may aid the physician when faced with a patient with the diagnostic dilemma of facial diplegia. | 2017 | 28409041 |
| lyme disease: a case report with typical and atypical lesions. | lyme disease is a multisystem infectious disease caused by the spirochete "borrelia burgdorferi," which is transmitted by "ixodes" tick, with skin being the most common and earliest organ to be affected. diagnosis of erythema chronicum migrans (ecm), which is the characteristic lesion of early disease, may help in early treatment and prevention of complications. here, we are reporting a case of lyme disease in a 10-year-old young boy from a non-endemic zone of himachal pradesh, who presented wit ... | 2017 | 28405553 |
| vertebrate ticks distribution and their role as vectors in relation to road edges and underpasses. | roads fragment vertebrate populations and affect the dynamics and dispersal patterns of vertebrate parasites. we evaluated how vertebrate ticks distribute near roads and road underpasses in human-caused road-fragmented landscapes in seville, sw spain. we sampled 49 stations with 93 individualized sampling points and assessed tick abundance. we explored the relationship between tick presence and abundance and distance to the nearest road and underpass (drainage culverts and other passages used by ... | 2017 | 28402742 |
| evaluation of the select tick control system (tcs), a host-targeted bait box, to reduce exposure to ixodes scapularis (acari: ixodidae) in a lyme disease endemic area of new jersey. | we describe a 2-yr trial to evaluate the ability of select tick control system (tcs) host-targeted bait boxes to reduce numbers of host-seeking ixodes scapularis nymphs in a residential neighborhood. after four successive 9-wk deployments, nymphal and larval i. scapularis infestation prevalence and intensity were significantly reduced on target small mammals. in addition, these deployments resulted in 87.9% and 97.3% control of host-seeking nymphs in treatment sites at 1 yr and 2 yr postinterven ... | 2017 | 28399280 |
| a risk model for the lyme disease vector ixodes scapularis (acari: ixodidae) in the prairie provinces of canada. | lyme disease is emerging in canada due to geographic range expansion of the tick vector ixodes scapularis say. recent areas of emergence include parts of the southeastern canadian prairie region. we developed a map of potential risk areas for future i. scapularis establishment in the canadian prairie provinces. six i. scapularis risk algorithms were developed using different formulations of three indices for environmental suitability: temperature using annual cumulative degree-days > 0 °c (dd > ... | 2017 | 28399276 |
| acquisition of borrelia burgdorferi infection by larval ixodes scapularis (acari: ixodidae) associated with engorgement measures. | measuring rates of acquisition of the lyme disease pathogen, borrelia burgdorferi sensu lato johnson, schmid, hyde, steigerwalt & brenner, by the larval stage of ixodes scapularis say is a useful tool for xenodiagnoses of b. burgdorferi in vertebrate hosts. in the nymphal and adult stages of i. scapularis, the duration of attachment to hosts has been shown to predict both body engorgement during blood feeding and the timing of infection with b. burgdorferi. however, these relationships have not ... | 2017 | 28399208 |
| plasmodium spp. and borrelia burgdorferi co-infection associated with antiphospholipid syndrome in a returned traveler: a case report. | the differential diagnosis of fever in a returned traveler is wide and challenging. we present a case of a patient working in africa, who returned with fever, constitutional symptoms, headache, and blurred vision. an initial diagnosis of malaria was made, and additional workup revealed borrelia burgdorferi co-infection and antiphospholipid syndrome. | 2017 | 28396771 |
| plasma fibronectin stabilizes borrelia burgdorferi-endothelial interactions under vascular shear stress by a catch-bond mechanism. | bacterial dissemination via the cardiovascular system is the most common cause of infection mortality. a key step in dissemination is bacterial interaction with endothelia lining blood vessels, which is physically challenging because of the shear stress generated by blood flow. association of host cells such as leukocytes and platelets with endothelia under vascular shear stress requires mechanically specialized interaction mechanisms, including force-strengthened catch bonds. however, the biome ... | 2017 | 28396443 |
| lyme disease and bell's palsy: an epidemiological study of diagnosis and risk in england. | lyme disease is caused by a tick-borne spirochaete of the borrelia species. it is associated with facial palsy, is increasingly common in england, and may be misdiagnosed as bell's palsy. | 2017 | 28396367 |
| morgellons disease. | morgellons disease is a rare disease with unknown etiology. herein, we report the first case of morgellons disease in korea. a 30-year-old woman presented with a 2-month history of pruritic erythematous patches and erosions on the arms, hands, and chin. she insisted that she had fiber-like materials under her skin, which she had observed through a magnifying device. we performed skin biopsy, and observed a fiber extruding from the dermal side of the specimen. histopathological examination showed ... | 2017 | 28392653 |
| in situ structural analysis of the spirochetal flagellar motor by cryo-electron tomography. | the bacterial flagellar motor is a large multi-component molecular machine. structural determination of such a large complex is often challenging and requires extensive structural analysis in situ. cryo-electron tomography (cryo-et) has emerged as a powerful technique that enables us to visualize intact flagellar motors in cells with unprecedented details. here, we detail the procedure beginning with sample preparation, followed by data acquisition, tomographic reconstruction, sub-tomogram analy ... | 2017 | 28389958 |
| three cases of early-stage localised lyme disease. | 2017 | 28387204 | |
| early disseminated lyme disease. | 2017 | 28385207 | |
| interferon-γ-induced protein 10 in lyme disease. | lyme disease is an infectious disease caused by bacteria of the borrelia type, that affects about 300,000 people a year in the usa and 65,000 people a year in europe. borrelia infection, and lyme disease, following occupational exposure has been frequently reported in usa, europe and asia. the manifestations of lyme disease include erythema migrans (em), arthritis, neuroborrelliosis (nb), and others. cytokines and chemokines primarily orchestrate leukocyte recruitment to the areas of borrelia in ... | 2017 | 28383628 |
| early disseminated lyme disease causing false positive serology for primary epstein-barr virus infection - report of 2 cases. | false positive serology for lyme disease was reported in patients with acute infectious mononucleosis. here we describe two patients with early-disseminated lyme disease who were misdiagnosed with infectious mononucleosis based on false positive tests for primary epstein-barr virus infection. | 2017 | 28379435 |
| serological evidence of exposure to zoonotic tick-borne bacteria in pheasants (phasianus colchicus). | previous studies on tick-borne pathogens in the avian population have focused mainly on the detection of the agents in ticks collected from birds, but data about the presence of tick-borne bacteria in these animals are scant. the aim of the presented study was to verify the exposure to some zoonotic tick-borne bacteria, in particular, anaplasma phagocytophilum, borrelia burgdorferi sensu lato, coxiella burnetii, and the rickettsia species of the spotted fever group (sfg), in pheasants (phasianus ... | 2017 | 28378988 |
| prevalence of infections and co-infections with 6 pathogens in dermacentor reticulatus ticks collected in eastern poland. | occurrence of co-infections with various pathogens in ixodid ticks creates a risk of increased severity of tick-borne diseases in humans and animals exposed to bite of the ticks carrying multiple pathogens. accordingly, co-infections in ticks were subject of numerous analyses, but almost exclusively with regard to ixodes ricinus complex whereas potential tick vectors belonging to other genera were much less studied. taking into consideration the role of dermacentor reticulatus in the transmissio ... | 2017 | 28378977 |
| estimation of cognitive and affective disorders occurrence in patients with lyme borreliosis. | lyme borreliosis (lb) is a disease caused by the bacteria borrelia burgdorferi. the most common symptoms are related to the skin, musculo-scelatal system, central and peripheral nervous system, rarely to the heart muscle and the eye, and may occur in the multistage course of the disease. lb may additionally be accompanied by psychopathological symptoms. the aim of the study is estimation of the cognitive and affective disorders occurence in patients with lb. | 2017 | 28378969 |
| was it authentic lyme disease or some other disorder? | we compared the evidence presented recently that challenges the long-standing belief that, in 1922, two french physicians reported the first case of neurological lyme disease with a further analysis of the original findings that were translated and re-published in 1993. alternative possibilities are offered that could explain these discrepant interpretations on what was considered to be a landmark clinical case of historical significance. | 2017 | 28369369 |
| standardized symptom measurement of individuals with early lyme disease over time. | understanding the lyme disease (ld) literature is challenging given the lack of consistent methodology and standardized measurement of symptoms and the impact on functioning. this prospective study incorporates well-validated measures to capture the symptom picture of individuals with early ld from time of diagnosis through 6-months post-treatment. | 2017 | 28365751 |
| commentary re: a critical appraisal of the mild axonal peripheral neuropathy of late neurologic lyme disease, by wormser et al. dmid 2016. | 2017 | 28365059 | |
| tick thioester-containing proteins and phagocytosis do not affect transmission of borrelia afzelii from the competent vector ixodes ricinus. | the present concept of the transmission of lyme disease from borrelia-infected ixodes sp. ticks to the naïve host assumes that a low number of spirochetes that manage to penetrate the midgut epithelium migrate through the hemocoel to the salivary glands and subsequently infect the host with the aid of immunomodulatory compounds present in tick saliva. therefore, humoral and/or cellular immune reactions within the tick hemocoel may play an important role in tick competence to act as a vector for ... | 2017 | 28361038 |
| the influence of abiotic and biotic factors on the invasion of ixodes scapularis in ontario, canada. | in northeastern north america, the blacklegged tick, ixodes scapularis, is the vector of numerous tick-borne pathogens, including the agent of lyme disease, borrelia burgdorferi sensu stricto. since 1990, there has been a rapid spread of i. scapularis northward into the province of ontario, canada. climate change has been implicated as one of the driving factors for the spread of this vector. other ecological factors also influence survival of i. scapularis populations and may facilitate invasio ... | 2017 | 28359751 |
| subacute parkinsonism as a complication of lyme disease. | 2017 | 28349210 | |
| [studies on lyme disease incidence rates in selected groups of forestry workers in west pomerania, 2005-2014]. | the data collected by sanitary-epidemiological stations in 2005-2014 were analyzed to determine the incidence rates of borreliosis lyme disease in the west pomerania group of workers exposed to tick bites. | 2017 | 28345681 |
| evaluating the submission of digital images as a method of surveillance for ixodes scapularis ticks. | widespread access to the internet is offering new possibilities for data collection in surveillance. we explore, in this study, the possibility of using an electronic tool to monitor occurrence of the tick vector of lyme disease, ixodes scapularis. the study aimed to compare the capacity for ticks to be identified in web-based submissions of digital images/photographs, to the traditional specimen-based identification method used by the provincial public health laboratory in quebec, canada. forty ... | 2017 | 28345501 |
| evaluation of lyme disease test utilization in a low-prevalence region. | 2017 | 28339873 | |
| survey of spatial distribution of vector-borne disease in neighborhood dogs in southern brazil. | neighborhood dogs may act as reservoirs and disseminators of vector-borne diseases in urban areas. accordingly, the aim of this study was to ascertain the health status and the vector-borne pathogens infecting dogs living in public areas with high levels of human movement in the city of curitiba, southern brazil. blood samples from 21 neighborhood dogs that were found in nine of 22 bus stations and two public parks were subjected to a complete blood cell (cbc) count, serum biochemical profiling, ... | 2017 | 28331833 |
| evaluation of biomérieux's dissociated vidas lyme igm ii and igg ii as a first-tier diagnostic assay for lyme disease. | the recommended laboratory diagnostic approach for lyme disease is a standard two-tiered testing (sttt) algorithm where the first tier is typically an enzyme immunoassay (eia) that if positive or equivocal is reflexed to western immunoblotting as the second tier. biomérieux manufactures one of the most commonly used first-tier eias in the united states, the combined igm/igg vidas test (lyt). recently, biomérieux launched its dissociated first-tier tests, the vidas lyme igm ii (lym) and igg ii (l ... | 2017 | 28330884 |
| evaluation of modified 2-tiered serodiagnostic testing algorithms for early lyme disease. | the conventional 2-tiered serologic testing protocol for lyme disease (ld), an enzyme immunoassay (eia) followed by immunoglobulin m and immunoglobulin g western blots, performs well in late-stage ld but is insensitive in patients with erythema migrans (em), the most common manifestation of the illness. western blots are also complex, difficult to interpret, and relatively expensive. in an effort to improve test performance and simplify testing in early ld, we evaluated several modified 2-tiered ... | 2017 | 28329259 |
| activity of sulfa drugs and their combinations against stationary phase b. burgdorferi in vitro. | lyme disease is a most common vector-borne disease in the us. although the majority of lyme patients can be cured with the standard two- to four-week antibiotic treatment, at least 10%-20% of patients continue to suffer from prolonged post-treatment lyme disease syndrome (ptlds). while the cause for this is unclear, one possibility is that persisting organisms are not killed by current lyme antibiotics. in our previous studies, we screened an fda drug library and an nci compound library on b. bu ... | 2017 | 28327498 |
| there is a method to the madness: strategies to study host complement evasion by lyme disease and relapsing fever spirochetes. | lyme disease and relapsing fever are caused by various borrelia species. lyme disease borreliae, the most common vector-borne pathogens in both the u.s. and europe, are transmitted by ixodes ticks and disseminate from the site of tick bites to tissues leading to erythema migrans skin rash, arthritis, carditis, and neuroborreliosis. relapsing fever borreliae, carried by ticks and lice, trigger reoccurring fever episodes. following transmission, spirochetes survive in the blood to induce bacteremi ... | 2017 | 28303129 |
| ligand co-crystallization of aminoacyl-trna synthetases from infectious disease organisms. | aminoacyl-trna synthetases (aarss) charge trnas with their cognate amino acid, an essential precursor step to loading of charged trnas onto the ribosome and addition of the amino acid to the growing polypeptide chain during protein synthesis. because of this important biological function, aminoacyl-trna synthetases have been the focus of anti-infective drug development efforts and two aars inhibitors have been approved as drugs. several researchers in the scientific community requested aminoacyl ... | 2017 | 28303005 |
| serological and molecular prevalence of canine vector-borne diseases (cvbds) in korea. | previous surveys in dogs from korea indicated that dogs are exposed to a variety of vector- borne pathogens, but perception for a nation-wide canine vector-borne disease (cvbd) occurrence has been missing. we report here results of both serological and molecular prevalence studies for major cvbds of dogs from all over the south korean peninsula except for jeju island. | 2017 | 28298245 |
| lyme disease: emergency department considerations. | lyme disease (ld) is the most common vector-borne illness in north america. reported cases of ld have increased from approximately 10,000 cases annually in 1991 to >25,000 cases in 2014. greater recognition, enhanced surveillance, and public education have contributed to the increased prevalence, as have geographic expansion and the number of infected ticks. cases are reported primarily in the northeastern united states, wisconsin, and minnesota, with children having the highest incidence of ld ... | 2017 | 28291638 |
| serological detection of antibodies to anaplasma spp., borrelia burgdorferi sensu lato and ehrlichia canis and of dirofilaria immitis antigen in dogs from costa rica. | in a study in costa rica 314 serum samples from dogs throughout all seven provinces were tested using a commercial kit for the detection of circulating antibodies against anaplasma spp., borrelia burgdorferi sensu lato and ehrlichia canis, and of circulating antigen of dirofilaria immitis. a total of 6.4% (20/314) and 38.2% (120/314) were positive for anaplasma spp. (an) and e. canis (ec) antibodies. overall, 8.0% (25/314) were positive for d. immitis (di) antigen. one single dog reacted positiv ... | 2017 | 28288773 |
| bacteria associated with marginal zone lymphomas. | in the last decades some bacteria have been associated with a various extent with marginal zone (extra nodal, nodal and splenic types) lymphomas are frequently associated with chronic infections, with important clinical, molecular, biological, and therapeutic implications. the well-known correlation between helicobacter pylori and gastric malt-lymphoma, the recently reported links between chlamydia psittaci and ocular adnexal malt-lymphoma and borrelia burgdorferi and cutaneous malt lymphoma con ... | 2017 | 28288714 |
| metabolomics of the tick-borrelia interaction during the nymphal tick blood meal. | the causal agents of lyme disease in north america, borrelia burgdorferi and borrelia mayonii, are transmitted primarily by ixodes scapularis ticks. due to their limited metabolic capacity, spirochetes rely on the tick blood meal for nutrients and metabolic intermediates while residing in the tick vector, competing with the tick for nutrients in the blood meal. metabolomics is an effective methodology to explore dynamics of spirochete survival and multiplication in tick vectors before transmissi ... | 2017 | 28287618 |
| diet-induced obesity does not alter tigecycline treatment efficacy in murine lyme disease. | obese individuals more frequently suffer from infections, as a result of increased susceptibility to a number of bacterial pathogens. furthermore, obesity can alter antibiotic treatment efficacy due to changes in drug pharmacokinetics which can result in under-dosing. however, studies on the treatment of bacterial infections in the context of obesity are scarce. to address this research gap, we assessed efficacy of antibiotic treatment in diet-induced obese mice infected with the lyme disease pa ... | 2017 | 28286500 |
| the enzootic life-cycle of borrelia burgdorferi (sensu lato) and tick-borne rickettsiae: an epidemiological study on wild-living small mammals and their ticks from saxony, germany. | borrelia burgdorferi (sensu lato) and rickettsiae of the spotted fever group are zoonotic tick-borne pathogens. while small mammals are confirmed reservoirs for certain borrelia spp., little is known about the reservoirs for tick-borne rickettsiae. between 2012 and 2014, ticks were collected from the vegetation and small mammals which were trapped in saxony, germany. dna extracted from ticks and the small mammals' skin was analyzed for the presence of rickettsia spp. and b. burgdorferi (s.l.) by ... | 2017 | 28285593 |
| searching for lyme borreliosis in australia: results of a canine sentinel study. | lyme borreliosis is a common tick-borne disease of the northern hemisphere that is caused by bacterial spirochaetes of the borrelia burgdorferi (sensu lato) (bbsl) complex. to date, there has been no convincing evidence for locally-acquired lyme borreliosis on the australian continent and there is currently a national debate concerning the nature and distributions of zoonotic tick-transmitted infectious disease in australia. in studies conducted in europe and the united states, dogs have been us ... | 2017 | 28285585 |
| electrocardiographic progression of acute lyme disease. | lyme carditis poses a challenge to physicians given dramatic clinical presentations like the one presented in this case. quite frequently, these young patients are implanted with permanent pacemakers; given lack of knowledge on the transient nature of the cardiac conduction system inflammation. this is the first case in the literature that has captured the electrocardiographic evolution of lyme carditis, day by day until complete resolution. | 2017 | 28279540 |
| borrelia burgdorferi keeps moving and carries on: a review of borrelial dissemination and invasion. | borrelia burgdorferi is the etiological agent of lyme disease, a multisystemic, multistage, inflammatory infection resulting in patients experiencing cardiac, neurological, and arthritic complications when not treated with antibiotics shortly after exposure. the spirochetal bacterium transmits through the ixodes vector colonizing the dermis of a mammalian host prior to hematogenous dissemination and invasion of distal tissues all the while combating the immune response as it traverses through it ... | 2017 | 28270812 |
| melting pot of tick-borne zoonoses: the european hedgehog contributes to the maintenance of various tick-borne diseases in natural cycles urban and suburban areas. | european hedgehogs (erinaceus europaeus) are urban dwellers and host both ixodes ricinus and ixodes hexagonus. these ticks transmit several zoonotic pathogens like borrelia burgdorferi (sensu lato), anaplasma phagocytophilum, rickettsia helvetica, borrelia miyamotoi and "candidatus neoehrlichia mikurensis". it is unclear to what extent hedgehogs in (sub) urban areas contribute to the presence of infected ticks in these areas, which subsequently pose a risk for acquiring a tick-borne disease. the ... | 2017 | 28270232 |
| borrelia burgdorferi manipulates innate and adaptive immunity to establish persistence in rodent reservoir hosts. | borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of the pathogen with its natural hosts. however, infected humans and other incidental hosts can develop lyme disease, a serious inflammatory syndrome characterized by tissue inflammation of joints, heart, muscles, skin, and cns. although b. burgdorfe ... | 2017 | 28265270 |
| presence of borrelia in different populations of ixodes pararicinus from northwestern argentina. | this work was performed to evaluate the presence of borrelia in different populations of ixodes pararicinus from northwestern argentina (jujuy, salta and tucumán provinces). questing adults and nymphs of i. pararicinus were collected from vegetation, and i. pararicinus nymphs were also collected on birds. eighty-two ticks were tested for borrelia presence by pcr targeting the gene flagellin and the rrfa-rrlb intergenic spacer region. pools of ticks positive to borrelia were formed by two nymphs ... | 2017 | 28262480 |
| borrelia diversity and co-infection with other tick borne pathogens in ticks. | identifying borrelia burgdorferi as the causative agent of lyme disease in 1981 was a watershed moment in understanding the major impact that tick-borne zoonoses can have on public health worldwide, particularly in europe and the usa. the medical importance of tick-borne diseases has long since been acknowledged, yet little is known regarding the occurrence of emerging tick-borne pathogens such as borrelia spp., anaplasma phagocytophilum, rickettsia spp., bartonella spp., "candidatus neoehrlichi ... | 2017 | 28261565 |
| tick humoral responses: marching to the beat of a different drummer. | ticks transmit a variety of human pathogens, including borrelia burgdorferi, the etiological agent of lyme disease. multiple pathogens that are transmitted simultaneously, termed "coinfections," are of increasing importance and can affect disease outcome in a host. arthropod immunity is central to pathogen acquisition and transmission by the tick. pattern recognition receptors recognize pathogen-associated molecular patterns and induce humoral responses through the toll and immune deficiency (im ... | 2017 | 28261180 |
| detection of lyme disease bacterium, borrelia burgdorferi sensu lato, in blacklegged ticks collected in the grand river valley, ontario, canada. | we document the presence of blacklegged ticks, ixodes scapularis, in the grand river valley, centre wellington, ontario. overall, 15 (36%) of 42 i. scapularis adults collected from 41 mammalian hosts (dogs, cats, humans) were positive for the lyme disease bacterium, borrelia burgdorferi sensu lato (s.l.). using real-time pcr testing and dna sequencing of the flagellin (fla) gene, we determined that borrelia amplicons extracted from i. scapularis adults belonged to b. burgdorferi sensu stricto (s ... | 2017 | 28260991 |
| evaluation of a serological test for the diagnosis of borrelia miyamotoi disease in europe. | borrelia miyamotoi causes systemic febrile illness and is transmitted by the same tick species that transmits borrelia burgdorferi sensu lato and tick-borne encephalitis virus. we describe a serological test using a fragment of glycerophosphodiester phosphodiesterase (glpq) as an antigen, and determined its performance in well-defined patient categories. | 2017 | 28259789 |
| vancomycin reduces cell wall stiffness and slows swim speed of the lyme disease bacterium. | borrelia burgdorferi, the spirochete that causes lyme disease, is a tick-transmitted pathogen that requires motility to invade and colonize mammalian and tick hosts. these bacteria use a unique undulating flat-wave shape to penetrate and propel themselves through host tissues. previous mathematical modeling has suggested that the morphology and motility of these spirochetes depends crucially on the flagellar/cell wall stiffness ratio. here, we test this prediction using the antibiotic vancomycin ... | 2017 | 28256234 |
| transmission differentials for multiple pathogens as inferred from their prevalence in larva, nymph and adult of ixodes ricinus (acari: ixodidae). | ixodes ricinus serves as vector for a range of microorganisms capable of causing clinical illness in humans. the microorganisms occur in the same vector populations and are generally affected by the same tick-host interactions. still, the instars have different host preferences which should manifest in different transmission patterns for various microorganisms in the tick populations, i.e., most microorganisms increase in prevalence rate from larvae to nymphs because their reservoirs are among s ... | 2017 | 28255923 |
| determination of seroprevalence of borrelia burgdorferi igg in adult population living in trabzon. | lyme borreliosis is a tick-borne, multi-systemic infectious disease that is thought to be wide spread in turkey even though studies on its seroprevalence are limited. | 2017 | 28251023 |
| first identification of rickettsia helvetica in questing ticks from a french northern brittany forest. | tick-borne rickettsiae are considered to be emerging, but data about their presence in western europe are scarce. ixodes ricinus ticks, the most abundant and widespread tick species in western europe, were collected and tested for the presence of several tick-borne pathogens in western france, a region never previously explored in this context. there was a high tick abundance with a mean of 4 females, 4.5 males, and 23.3 nymphs collected per hour per collector. out of 622 tested ticks, specific ... | 2017 | 28248955 |
| detection of borrelia burgdorferi sensu lato and anaplasma phagocytophilum in questing ticks ixodes ricinus from the czech republic. | the aim of the present study is to compare the prevalence of borrelia burgdorferi sensu lato (s.l.) and anaplasma phagocytophilum in questing ticks by using molecular methods from spring to autumn 2007. a total of 526 ixodes ricinus ticks were collected from vegetation in three different sampling sites, representing an urban area (city park), a suburban area (village) and a natural montane habitat. the prevalence of b. burgdorferi s.l. was 17.3% (7.5% in males, 18.7% in females and 20.2% in nymp ... | 2017 | 28238642 |