Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| relationship between glycemic control and diabetes-related hospital costs in patients with type 1 or type 2 diabetes mellitus. | diabetes mellitus requires continuous medical care and patient self-management in order to prevent short-term complications and decrease the risk of long-term complications, which can result in substantial increases in the total economic burden of the disease. findings from randomized clinical trials have shown that improved glycemic control may reduce the risk of long-term complications as long as a target for hemoglobin a1c is not set below 7% for intensive glycemic control. however, limited d ... | 2010 | 20433217 |
| consent for genetic research in the framingham heart study. | extensive efforts have been aimed at understanding the genetic underpinnings of complex diseases that affect humans. numerous genome-wide association studies have assessed the association of genes with human disease, including the framingham heart study (fhs), which genotyped 550,000 snps in 9,000 participants. the success of such efforts requires high rates of consent by participants, which is dependent on ethical oversight, communications, and trust between research participants and investigat ... | 2010 | 20425830 |
| frequent occurrence of conserved extended haplotypes (cehs) in two caucasian populations. | conserved extended haplotypes (cehs) are large (>or=1mb) regions of identical dna of the major histocompatibility complex (mhc) region of chromosome 6p in unrelated individuals. they are recognized by family studies and constitute nearly half of mhc haplotypes among european caucasians. we studied 49 hungarian caucasian families in comparison with the previous findings in 2675 normal american caucasian chromosomes from families in the boston area. besides hla-a, -b and hla-drb1/-dqb1 alleles, co ... | 2010 | 20409590 |
| mat1a variants are associated with hypertension, stroke, and markers of dna damage and are modulated by plasma vitamin b-6 and folate. | the s-adenosylmethionine synthetase type 1 (mat1a) gene encodes a key enzyme in one-carbon nutrient metabolism. | 2010 | 20335551 |
| genetic variants and risk of lung cancer in never smokers: a genome-wide association study. | lung cancer in individuals who have never smoked tobacco products is an increasing medical and public-health issue. we aimed to unravel the genetic basis of lung cancer in never smokers. | 2010 | 20304703 |
| genetic heritage and native identity of the seaconke wampanoag tribe of massachusetts. | the name "wampanoag" means "eastern people" or "people of the first light" in the local dialect of the algonquian language. once extensively populating the coastal lands and neighboring islands of the eastern united states, the wampanoag people now consist of two federally recognized tribes, the aquinnah and mashpee, the state-recognized seaconke wampanoag tribe, and a number of bands and clans in present-day southern massachusetts. because of repeated epidemics and conflicts with english coloni ... | 2010 | 20229500 |
| mortality trends of stranded marine mammals on cape cod and southeastern massachusetts, usa, 2000 to 2006. | to understand the cause of death of 405 marine mammals stranded on cape cod and southeastern massachusetts between 2000 and 2006, a system for coding final diagnosis was developed and categorized as (1) disease, (2) human interaction, (3) mass-stranded with no significant findings, (4) single-stranded with no significant findings, (5) rock and/or sand ingestion, (6) predatory attack, (7) failure to thrive or dependent calf or pup, or (8) other. the cause of death for 91 animals could not be dete ... | 2010 | 20225675 |
| black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in microrna processing genes. | black carbon (bc) is a marker of traffic pollution that has been associated with blood pressure (bp), but findings have been inconsistent. micrornas (mirnas) are emerging as key regulators of gene expression, but whether polymorphisms in genes involved in processing of mirnas to maturity influence susceptibility to bc has not been elucidated. | 2010 | 20211803 |
| accuracy assessment of pharmacogenetically predictive warfarin dosing algorithms in patients of an academic medical center anticoagulation clinic. | the objectives of this retrospective cohort study are to evaluate the accuracy of pharmacogenetic warfarin dosing algorithms in predicting therapeutic dose and to determine if this degree of accuracy warrants the routine use of genotyping to prospectively dose patients newly started on warfarin. seventy-one patients of an outpatient anticoagulation clinic at an academic medical center who were age 18 years or older on a stable, therapeutic warfarin dose with international normalized ratio (inr) ... | 2010 | 20204461 |
| predicting virologic failure in an hiv clinic. | we sought to use data captured in the electronic health record (ehr) to develop and validate a prediction rule for virologic failure among patients being treated for infection with human immunodeficiency virus (hiv). | 2010 | 20121574 |
| sexually transmitted disease (std) diagnoses and mental health disparities among women who have sex with women screened at an urban community health center, boston, ma, 2007. | a growing body of research documents mental health disparities among women who have sex with women (wsw) compared with women who have sex with men only (wsm). however, there remains a dearth of research exploring these indicators alongside sexually transmitted diseases (stds) and wsw sexual health. | 2010 | 20118673 |
| beyond the information given: infants' transfer of actions learned through imitation. | five experiments were conducted to investigate infants' ability to transfer actions learned via imitation to new objects and to examine what components of the original context are critical to such transfer. infants of 15 months observed an experimenter perform an action with one or two toys and then were offered a novel toy that was not demonstrated for them. in all experiments, infants performed target actions with the novel toy more frequently than infants who were offered the same toy but had ... | 2010 | 20116804 |
| mapping and measuring disparities in welfare for cats across neighborhoods in a large us city. | to determine whether disparities in health and welfare among cats are present within neighborhoods and across census tracts in a large us city, and to compare results with area-level human data. | 2010 | 20113223 |
| sources of human immunodeficiency virus and sexually transmitted disease information and responses to prevention messages among massachusetts men who have sex with men. | sexually transmitted disease (std) rates have continued to increase among men who have sex with men (msm). the present study used qualitative methods to assess sources of human immunodeficiency virus (hiv)/std information and responses to hiv/std prevention messages among msm. this was done to understand how to design more effective media campaigns on hiv/std prevention and testing for this population. | 2010 | 20073382 |
| a view from riggs: treatment resistance and patient authority-xii. examined living: a psychodynamic treatment system. | hospitalized patients with treatment resistant comorbid axis i and ii psychiatric disorders have in common a developmental history that includes a lack of fit between their needs and their human environment. adaptation of their personalities to this environmental failure contributes to these patients' lack of trust in authority. treatment resistance may represent a repetition of this early experience, with the current biological and symptom focus of the field representing yet another insufficien ... | 2009 | 20001200 |
| relative impact of influenza and respiratory syncytial virus in young children. | we measured the relative impact of influenza and respiratory syncytial virus (rsv) infections in young children in terms of emergency department (ed) visits, clinical care requirements, and overall resource use. | 2009 | 19933730 |
| boston medical center pediatric emergency response to h1n1. | 2009 | 19914494 | |
| five-year clinical follow-up after implantation of the endeavor zotarolimus-eluting stent: endeavor i, first-in-human study. | to evaluate the 5-year clinical outcomes of patients treated with the endeavor zotarolimus-eluting stent (zes) in the endeavor i first-in-human study. | 2009 | 19859958 |
| college men's knowledge, attitudes, and beliefs about the human papillomavirus infection and vaccine. | men enrolled in an urban university participated in focus groups (k=6; n=45) to explore knowledge about human papillomavirus and attitudes toward prophylactic vaccine. results suggest that regardless of whether vaccines become available to men, educational efforts should include them, as men tend to have many misconceptions and do not perceive themselves to be vulnerable. | 2009 | 19837363 |
| apolipoprotein a5 polymorphisms interact with total dietary fat intake in association with markers of metabolic syndrome in puerto rican older adults. | apoa5 -1131t > c and s19w single nucleotide polymorphisms (snp) have been consistently associated with plasma lipid concentration and metabolic syndrome (mets), alone and in modulation by dietary factors. puerto ricans have a high prevalence of metabolic conditions and high minor allele frequency for these snp, suggesting a possible role in disease for this population. we aimed to determine the association of apoa5 -1131t > c and s19w with plasma lipids and markers of mets, alone and in interact ... | 2009 | 19828688 |
| food availability differentially influences young males' and females' cognitive processes in accordance with sexual selection theory. | sexual selection theory predicts that additional resources will have a greater impact on males' compared with females' reproductive success. consequently, we expected that strong cues signalling increased resource availability should augment cognitive functioning associated with long-term maximization of reproductive outcomes (inhibition, working memory) in human males. in human females, who can rely on assistance in resource-rich environments, we expected the opposite effect. we tested this pre ... | 2010 | 19828494 |
| cleft palate in pfeiffer syndrome. | the frequency of associated cleft palate is known to be high in some fibroblast growth factor receptor 2 (fgfr2)-mediated craniosynostosis syndromes, such as apert syndrome. however, there is little information on the frequency of palatal clefts in the fgfr2-mediated disorder, that is, pfeiffer syndrome. the purpose of this study was to determine the frequency of palatal clefts in patients with pfeiffer syndrome. the records of patients with pfeiffer syndrome managed in our craniofacial unit wer ... | 2009 | 19816260 |
| prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of congenital anomalies: a retrospective cohort study. | prior animal and human studies of prenatal exposure to solvents including tetrachloroethylene (pce) have shown increases in the risk of certain congenital anomalies among exposed offspring. | 2009 | 19778411 |
| integrating professional behavior development across a professional allied health curriculum. | professional behaviors are an integral part of clinical practice in all allied health and medical fields. a systematic process for instruction, the education, and development of professional behaviors, cannot be taught in the same way that memorization of human anatomy or medical terminology is taught. one cannot expect professional behaviors to just appear in an individual upon graduation and entry into a health care field. professional behavior development is an essential component of physical ... | 2007 | 19759999 |
| insulin resistance and risk of incident hypertension among men. | j clin hypertens (greenwich). 2009;11:483-490. (c) 2009 wiley periodicals, inc.the independent association between insulin resistance and the development of hypertension remains in doubt because insulin resistance correlates with other metabolic factors also proposed to be associated with hypertension. the authors examined the association between the insulin sensitivity index and incident hypertension in a prospective nested case-control study among 1453 men (mean age, 61 years) who participated ... | 2009 | 19751460 |
| be prepared. when a virus outbreak hits, hospital leaders must ready more beds, educate patients, and keep staff in the loop. | it is critical that hospitals and health systems can quickly activate plans to increase bed capacity and stage screening areas in the event of a disease outbreak. another piece of a hospital's emergency plan should include posting information on the homepage for patients. some organizations have implemented tracking and bed management systems to provide clinicians with better visibility on what space is available for triage. communication with staff is crucial during an emergency. whether it is ... | 2009 | 19722324 |
| integrating research training into residency: tools of human investigation. | although the need for new physician-clinical scientists has never been greater, significant obstacles deter young physicians from careers in clinical research. local and federal programs have sought to stimulate interest in clinical research among young physicians, medical students, and even undergraduates, but few formal programs have specifically focused on stimulating interest among residents in training. the recent implementation of strict duty hours regulations has provided residents with a ... | 2009 | 19707076 |
| self-supervised artmap. | computational models of learning typically train on labeled input patterns (supervised learning), unlabeled input patterns (unsupervised learning), or a combination of the two (semi-supervised learning). in each case input patterns have a fixed number of features throughout training and testing. human and machine learning contexts present additional opportunities for expanding incomplete knowledge from formal training, via self-directed learning that incorporates features not previously experien ... | 2010 | 19699053 |
| the effects of abcg5/g8 polymorphisms on hdl-cholesterol concentrations depend on abca1 genetic variants in the boston puerto rican health study. | atp-binding cassette transporters g5/g8 (abcg5/g8) are associated with hdl-c concentrations. to assess whether the effect of abcg5/g8 genetic variants on hdl-c concentrations is dependent on atp-binding cassette transporters a1 (abca1), we studied potential interactions between single nucleotide polymorphisms (snps) at abcg5/g8 (i7892t > c, 5u145a > c, t54ca > g, t400kc > a) and abca1 (i27943g > a, i48168g > a, k219rg > a, i125970g > c, 3u8995a > g) genes with hdl-c concentrations. | 2010 | 19692220 |
| a genome scan in affected sib-pairs with familial vesicoureteral reflux identifies a locus on chromosome 5. | the basis for vesicoureteral reflux (vur) is considered to be primarily genetic, with a 30-50% incidence of vur in first-degree relatives of patients. the search for the causative gene or genes has been elusive, likely because of vur being genetically heterogeneous with complex inheritance patterns. in this study, a genome-wide analysis of vur with high-density single nucleotide polymorphisms was conducted with the aim of identifying susceptibility loci for vur in 98 families with two or more af ... | 2010 | 19690587 |
| diversity of francisella species in environmental samples from martha's vineyard, massachusetts. | we determined whether francisella spp. are present in water, sediment, and soil from an active tularemia natural focus on martha's vineyard, massachusetts, during a multiyear outbreak of pneumonic tularemia. environmental samples were tested by polymerase chain reaction (pcr) targeting francisella species 16s rrna gene and succinate dehydrogenase a (sdha) sequences; evidence of the agent of tularemia was sought by amplification of francisella tularensis-specific sequences for the insertion eleme ... | 2010 | 19669828 |
| the frequency of palatal anomalies in saethre-chotzen syndrome. | saethre-chotzen syndrome (scs) is an autosomal dominant disorder with widespread phenotypic variability. cardinal features include coronal synostosis, blepharoptosis, and limb abnormalities. cleft palate can also occur, but there are few reports on its frequency. this study was undertaken to determine the prevalence of palatal anomalies in this population. | 2009 | 19642760 |
| apolipoprotein a5 and lipoprotein lipase interact to modulate anthropometric measures in hispanics of caribbean origin. | apolipoprotein a5 (apoa5) and lipoprotein lipase (lpl) proteins interact functionally to regulate lipid metabolism, and single-nucleotide polymorphisms (snps) for each gene have also been associated independently with obesity risk. evaluating gene combinations may be more effective than single snp analyses in identifying genetic risk, but insufficient minor allele frequency (maf) often limits evaluations of potential epistatic relationships. populations with multiple ancestral admixtures may pro ... | 2010 | 19629056 |
| metapopulation structure for perpetuation of francisella tularensis tularensis. | outbreaks of type a tularemia due to francisella tularensis tularensis are typically sporadic and unstable, greatly hindering identification of the determinants of perpetuation and human risk. martha's vineyard, massachusetts has experienced an outbreak of type a tularemia which has persisted for 9 years. this unique situation has allowed us to conduct long-term eco-epidemiologic studies there. our hypothesis is that the agent of type a tularemia is perpetuated as a metapopulation, with many sma ... | 2009 | 19627585 |
| formation of personal hiv disclosure policies among hiv-positive men who have sex with men. | given the increasing emphasis on "prevention with positives" programs designed to promote hiv transmission risk reduction among people living with hiv/aids, better understanding of influences upon serostatus disclosure in sexual situations is needed. based on grounded theory analyses of individual interviews, this exploratory research hypothesizes and interprets how 15 hiv-positive men who have sex with men (msm) formed personal hiv disclosure policies for sexual situations. participants describ ... | 2009 | 19621994 |
| evidence-based practice, clinical simulations workshop, and intravenous medications: moving toward safer practice. | in an era of increased emphasis on medication safety practice, a gap exists in the translation of research to clinical practice for administering intravenous continuous infusion medications. an educational initiative was designed for medical-surgical nurses in a tertiary care center to standardize operational procedures in a clinical model focusing on evidence-based practice. | 2009 | 19591361 |
| factors associated with rabid animals since the introduction of raccoon rabies variant in massachusetts, 1992-2007. | rabies virus has been identified in 26 animal species since the introduction of the raccoon rabies variant (rrv) into the commonwealth of massachusetts in 1992. this study used data from 47,162 testable specimens, including 4538 (9.62%) rabid animals, to produce a multi-categorical logistic regression model to identify factors associated with a positive rabies laboratory test. the model was adjusted by the animal type and animal species, using the least tested and the least found rabid animal sp ... | 2010 | 19589059 |
| multicenter study of knowledge about human papilloma virus and attitudes among emergency department patients. | we sought to evaluate knowledge of human papilloma virus (hpv) and attitudes toward the hpv vaccine among emergency department (ed) patients. | 2009 | 19576825 |
| seasonal source-sink dynamics at the edge of a species' range. | the roles of dispersal and population dynamics in determining species' range boundaries recently have received theoretical attention but little empirical work. here we provide data on survival, reproduction, and movement for a virginia opossum (didelphis virginiana) population at a local distributional edge in central massachusetts (usa). most juvenile females that apparently exploited anthropogenic resources survived their first winter, whereas those using adjacent natural resources died of sta ... | 2009 | 19569372 |
| infant sex predicts breast milk energy content. | during human evolutionary history, and for many around the world, breast milk is the primary source of nutritional energy for infants. variation in breast milk quality might logically have important effects on infant health, growth, and development, yet the sources of this variation remain largely unelucidated. we quantified nutrient and energy content of breast milk from 25 healthy, well-nourished massachusetts mothers with infants aged 2-5 months. we examined several potential sources of varia ... | 2010 | 19533619 |
| impact of tabletop exercises on participants' knowledge of and confidence in legal authorities for infectious disease emergencies. | legal preparedness is a critical component of comprehensive public health preparedness for public health emergencies. the scope of this study was to assess the usefulness of combining didactic sessions with a tabletop exercise as educational tools in legal preparedness, to assess the impact of the exercise on the participants' level of confidence about the legal preparedness of a public health system, and to identify legal issue areas in need of further improvement. | 2009 | 19491605 |
| ergonomic and socioeconomic risk factors for hospital workers' compensation injury claims. | hospital workers are a diverse population with high rates of musculoskeletal disorders (msds). the risk of msd leading to workers' compensation (wc) claims is likely to show a gradient by socioeconomic status (ses) that may be partly explained by working conditions. | 2009 | 19479820 |
| sexual mixing patterns and partner characteristics of black msm in massachusetts at increased risk for hiv infection and transmission. | black men who have sex with men (msm) are at increased risk for hiv infection in the united states compared to other msm. the aim of this study was to investigate black msm's sexual mixing patterns and partner characteristics in relation to sexual risk taking, as a possible explanation for this observed increase in hiv incidence. between january and july 2008, 197 black msm were recruited via modified respondent-driven sampling and completed optional pretest and post-test hiv serological testing ... | 2009 | 19466554 |
| salt marsh sediment bacteria: their distribution and response to external nutrient inputs. | a primary focus among microbial ecologists in recent years has been to understand controls on the distribution of microorganisms in various habitats. much less attention has been paid to the way that environmental disturbance interacts with processes that regulate bacterial community composition. we determined how human disturbance affected the distribution and community structure of salt marsh sediment bacteria by using denaturing gradient gel electrophoresis of 16s rrna in five different habit ... | 2009 | 19421233 |
| insulin-like growth factor levels in cord blood, birth weight and breast cancer risk. | breast cancer incidence and birth weight are higher among caucasian than asian women, and birth size has been positively associated with breast cancer risk. pregnancy hormone levels, however, have been generally lower in caucasian than asian women. we studied components of the insulin-like growth factor (igf) system in cord blood from 92 singleton babies born in boston, usa, and 110 born in shanghai, china, in 1994-1995. cord blood igf-1 was significantly higher among caucasian compared with chi ... | 2009 | 19417744 |
| genome-wide analysis of survival in early-stage non-small-cell lung cancer. | lung cancer, of which 85% is non-small-cell (nsclc), is the leading cause of cancer-related death in the united states. we used genome-wide analysis of tumor tissue to investigate whether single nucleotide polymorphisms (snps) in tumors are prognostic factors in early-stage nsclc. | 2009 | 19414679 |
| partner notification after std and hiv exposures and infections: knowledge, attitudes, and experiences of massachusetts men who have sex with men. | we assessed boston-area men who have sex with men (msm) in terms of their knowledge of partner notification (pn)/partner counseling and referral services (pcrs) and intentions to use such services if exposed to/infected with a sexually transmitted disease (std) or human immunodeficiency virus (hiv) in the future. | 2009 | 19413033 |
| predicting atrial fibrillation. | 2009 | 19410714 | |
| animal rabies in massachusetts, 1985-2006. | in this study, we review annual rabies data from massachusetts from 1985 to 2006, spanning the introduction of raccoon strain rabies in 1992. of 52,034 animals tested, 9.7% (5,049/52,034) were rabid, representing 26 of over 67 species submitted. bats were the most common rabid animals prior to 1992 (50 of 52), but raccoons (procyon lotor) became the most common rabies-positive species upon arrival of raccoon strain rabies virus (38.2%, 2,728 of 7,138 tested), followed by striped skunks (mephitis ... | 2009 | 19395747 |
| anal human papillomavirus infection is associated with hiv acquisition in men who have sex with men. | human papillomavirus (hpv) is a common sexually transmitted agent that causes anogenital cancer and precancer lesions that have an inflammatory infiltrate, may be friable and bleed. our aim was to determine the association between anal hpv infection and hiv acquisition. | 2009 | 19390418 |
| p53 arg72pro and mdm2 t309g polymorphisms, histology, and esophageal cancer prognosis. | this study aimed to evaluate the prognostic significance of two functional single nucleotide polymorphisms (snp) in the p53 pathway (p53 arg72pro and mdm2 t309g) in patients with esophageal cancer, and to determine the importance of histologic subtype in the snp-outcome relationships. | 2009 | 19383811 |
| history of space medicine: the formative years at nasa. | almost nothing was known about the effects of spaceflight on human physiology when, in may of 1961, president john f. kennedy committed the united states to land a man on the moon and return him safely to earth within the decade. there were more questions than answers regarding the effects of acceleration, vibration, cabin pressure, co2 concentration, and microgravity. there were known external threats to life, such as solar and ultraviolet radiation, meteorites, and extreme temperatures as well ... | 2009 | 19378903 |
| an assessment of sources and pathways of human exposure to polybrominated diphenyl ethers in the united states. | polybrominated diphenyl ethers (pbdes) are ubiquitous in the indoor environment, owing to their use in consumer products ranging from electronics to mattresses, furniture, and carpets. people are exposed to pbdes through inhalation of indoor air and ingestion, and dermal absorption of dust particles present in the air. in this study, concentrations of pbdes were determined in indoor air and house dust collected from homes in albany, new york, usa. based on the measured concentrations of pbdes in ... | 2009 | 19349061 |
| exposure to breast milk in infancy and risk of breast cancer. | early life exposures, such as being breastfed in infancy, may influence the risk of breast cancer in adulthood. we evaluated the risk of breast cancer in relation to ever having been breastfed in infancy among 9,442 women who participated in a population-based, case-control study. cases were identified through cancer registries in three states (massachusetts, new hampshire, and wisconsin); controls were identified through statewide drivers' license lists or medicare lists. data on known and susp ... | 2009 | 19330531 |
| early adulthood uprooted: transitoriness in young women with breast cancer. | young women with breast cancer face a more aggressive disease and lower survival rate compared with those who are older, thereby confronting the potential finitude of life or transitoriness at a time when they are establishing their careers, developing partnerships, and building families. little is known about the perspectives of young women with breast cancer in how they consider issues of their own mortality. patients with stage i to iii breast cancer aged 39 years and younger who were diagnos ... | 2009 | 19295418 |
| resistin, adiponectin, and risk of heart failure the framingham offspring study. | we tested the association of the adipokines resistin and adiponectin with incident heart failure. | 2009 | 19245965 |
| a walk in the park: a case study in research ethics. | can researchers, interested in novel ways to assess hiv seroprevalence among populations which are otherwise hidden, collect condoms that have been discarded on the ground in a public sex environment and test them for hiv? researchers, who use other types of abandoned samples, such as discarded syringes, hair or saliva samples, or excess biological samples, confront similar issues. this review evaluates whether such abandoned tissues can be studied based on u.s. code of federal regulations and l ... | 2009 | 19245606 |
| participant experiences in a breastmilk biomonitoring study: a qualitative assessment. | biomonitoring studies can provide information about individual and population-wide exposure. however they must be designed in a way that protects the rights and welfare of participants. this descriptive qualitative study was conducted as a follow-up to a breastmilk biomonitoring study. the primary objectives were to assess participants' experiences in the study, including the report-back of individual body burden results, and to determine if participation in the study negatively affected breastf ... | 2009 | 19226469 |
| antiviral and antibiotic prescribing for influenza in primary care. | anti-influenza antiviral medications reduce influenza-related morbidity, but may often be used inappropriately. | 2009 | 19225847 |
| the effect of angiotensin-blocking agents on liver fibrosis in patients with hepatitis c. | multiple studies implicate the renin-angiotensin system in hepatic fibrogenesis. few studies have examined the effects of angiotensin blockade on liver fibrosis via human histology. | 2009 | 19220742 |
| polybrominated diphenyl ether (pbde) concentrations in house dust are related to hormone levels in men. | despite documented widespread human exposure to polybrominated diphenyl ethers (pbdes) through dietary intake and contact with or inhalation of indoor dust, along with growing laboratory evidence for altered endocrine function following exposure, human studies of pbde exposure and endocrine effects remain limited. we conducted a preliminary study within an ongoing study on the impact of environmental exposures on male reproductive health. we measured serum hormone levels and pbde concentrations ... | 2009 | 19211133 |
| improving the health of diabetic patients through resident-initiated group visits. | group visits have the potential to benefit patients with chronic illnesses. our objective was to implement resident-run diabetic group visits that would improve patient education and help patients become more involved in their care. | 2009 | 19184689 |
| tcf7l2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the framingham heart study. | common variants in the tcf7l2 gene are associated with type 2 diabetes via impaired insulin secretion. one hypothesis is that variation in tcf7l2 impairs insulin processing in the beta cell. in contrast, the association of related tcf7l2 polymorphisms with obesity is controversial in that it has only been shown in cohorts susceptible to ascertainment bias. we reproduced the association of diabetes-associated variants with proinsulin/insulin ratios, and also examined the association of a tcf7l2 h ... | 2009 | 19183934 |
| cardiovascular, inflammatory, and metabolic consequences of sleep deprivation. | that insufficient sleep is associated with poor attention and performance deficits is becoming widely recognized. fewer people are aware that chronic sleep complaints in epidemiologic studies have also been associated with an increase in overall mortality and morbidity. this article summarizes findings of known effects of insufficient sleep on cardiovascular risk factors including blood pressure, glucose metabolism, hormonal regulation, and inflammation with particular emphasis on experimental s ... | 2009 | 19110131 |
| shire dumps dynepo. | 2008 | 19060856 | |
| elevated house dust and serum concentrations of pbdes in california: unintended consequences of furniture flammability standards? | studies show higher house dust and body burden levels of pbde flame retardants in north america than europe; but little is known about exposure variation within north america, where california's furniture flammability standard affects pbde use. we compared dust samples from 49 homes in two california communities with 120 massachusetts homes and with other published studies. dust concentrations [median (range) ng/g] in california homes of bde-47, -99, and -100 were 2700 (112-107,000), 3800 (102-1 ... | 2008 | 19031918 |
| the effects of abcg5/g8 polymorphisms on plasma hdl cholesterol concentrations depend on smoking habit in the boston puerto rican health study. | low hdl-cholesterol (hdl-c) is associated with an increased risk for atherosclerosis, and concentrations are modulated by genetic factors and environmental factors such as smoking. our objective was to assess whether the association of common single-nucleotide polymorphisms (snps) at abcg5/g8 (i18429g>a, i7892t>c, gln604gluc>g, 5u145a>c, tyr54cysa>g, asp19hisg>c, i14222a>g, and thr400lysc>a) genes with hdl-c differs according to smoking habit. abcg5/g8 snps were genotyped in 845 participants (24 ... | 2009 | 19005228 |
| movie magic in the clinic: computer-generated characters for automated health counseling. | in this presentation, i demonstrate how many of the technologies used in movie special effects and games have been successfully used in health education and behavior change interventions. computer-animated health counselors simulate human face-to-face dialogue as a computer interface medium, including not only verbal behavior but nonverbal conversational behavior such as hand gesture, body posture shifts, and facial display of emotion. this technology has now been successfully used in a wide ran ... | 2008 | 18999232 |
| personal genomes: a disruptive personality, disrupted. | 2008 | 18987711 | |
| influenza vaccination in adolescents with high-risk conditions. | we assessed influenza vaccination rates from 1992 to 2002, individual continuity of vaccination, and missed opportunities for vaccination in adolescents with high-risk conditions. | 2008 | 18977969 |
| using stem cells and reprogramming to understand disease. | kevin eggan received his phd in biology from the massachusetts institute of technology in february 2003. he is currently an assistant professor of stem cell and regenerative biology at harvard university. dr eggan has devoted the last 7 years to performing stem cell research. he is currently leading a research group that is investigating the mechanisms regulating epigenetic reprogramming after somatic cell nuclear transfer and using nuclear transfer techniques to derive disease-specific human em ... | 2008 | 18947303 |
| acculturation of host individuals: immigrants and personal networks. | there has been a vast amount of research on the changes experienced by immigrants, but little is known about the changes experienced by host individuals. this article focuses on the role of host individuals in the networks of relations between immigrant populations and the communities from the dominant culture, as well as the changes experienced by host individuals because of their continuous contact with immigrants. this research applied a network approach to the study of the acculturation of h ... | 2008 | 18923893 |
| outbreak of listeria monocytogenes infections associated with pasteurized milk from a local dairy--massachusetts, 2007. | on november 27, 2007, a local health officer in central massachusetts contacted the massachusetts department of public health (mdph) to report listeriosis in a man aged 87 years. pulsed-field gel electrophoresis (pfge) performed on the patient's listeria monocytogenes isolate produced a pattern indistinguishable from that of isolates from three other cases identified in residents of central massachusetts in june, october, and early november 2007. mdph, in collaboration with local public health o ... | 2008 | 18846031 |
| patient risks, outcomes, and costs of voluntary hiv testing at five testing sites within a medical center. | the centers for disease control and prevention (cdc) recommends offering human immunodeficiency virus (hiv) testing to all patients in all high hiv-prevalence clinical settings. we evaluated programmatic aspects of hiv testing across multiple clinical settings within a single medical center. | 2008 | 18828416 |
| point-of-care glucose and hemoglobin a1c in emergency department patients without known diabetes: implications for opportunistic screening. | the objectives were to evaluate the correlation between random glucose and hemoglobin a1c (hba1c) in emergency department (ed) patients without known diabetes and to determine the ability of diabetes screening in the ed to predict outpatient diabetes. | 2008 | 18785943 |
| talc use, variants of the gstm1, gstt1, and nat2 genes, and risk of epithelial ovarian cancer. | epidemiologic evidence suggests a possible association between genital use of talcum powder and risk of epithelial ovarian cancer; however, the biological basis for this association is not clear. we analyzed interactions between talc use and genes in detoxification pathways [glutathione s-transferase m1 (gstm1), glutathione s-transferase t1 (gstt1), and n-acetyltransferase 2 (nat2)] to assess whether the talc/ovarian cancer association is modified by variants of genes potentially involved in the ... | 2008 | 18768514 |
| discussions about preventive services: a qualitative study. | elderly minority patients are less likely to receive influenza vaccination and colorectal cancer screening than are other patients. communication between primary care providers (pcps) and patients may affect service receipt. | 2008 | 18768086 |
| fatal fires associated with smoking during long-term oxygen therapy--maine, massachusetts, new hampshire, and oklahoma, 2000-2007. | approximately 1 million persons in the united states receive long-term oxygen therapy (ltot) annually through the medicare program, most often for smoking-related lung disease. at 2:10 a.m. on december 14, 2007, a fire occurred in a public housing project for the elderly in westbrook, maine. approximately 60 residents were evacuated; six were transported to a hospital for smoke inhalation. the fire was caused unintentionally by a woman aged 57 years who was an overnight guest of a relative who l ... | 2008 | 18685553 |
| repetitive stress symptoms in radiology: prevalence and response to ergonomic interventions. | to determine the prevalence of repetitive stress symptoms among radiologists working in a archiving and communication systems (pacs) environment and to assess their responses to ergonomic interventions. | 2008 | 18657788 |
| brief report: lymphocytic choriomeningitis virus transmitted through solid organ transplantation--massachusetts, 2008. | lymphocytic choriomeningitis virus (lcmv) is a rodent-borne arenavirus found worldwide. house mice (mus musculus) are the natural reservoir, but lcmv also can infect other wild, pet, and laboratory rodents (e.g., rats, mice, guinea pigs, and hamsters). humans can be infected through exposure to rodent excreta. person-to-person transmission has occurred only through maternal-fetal transmission and solid organ transplantation. lcmv infection in humans can be asymptomatic or cause a spectrum of ill ... | 2008 | 18650788 |
| colostrum iodine and perchlorate concentrations in boston-area women: a cross-sectional study. | to measure levels of colostrum iodine, which has not been previously measured, and perchlorate and cotinine (a surrogate for thiocyanate derived from cigarette smoke) in women up to 60 h postpartum. perchlorate and thiocyanate are environmental inhibitors of iodide transport into the thyroid and lactating breast. | 2009 | 18616704 |
| risk factors for proteinuria in hiv-infected and -uninfected hispanic drug users. | proteinuria may be an early marker of chronic kidney disease in human immunodeficiency virus (hiv)-infected patients with coexisting chronic hepatitis and/or drug use. minorities are at greater risk of chronic kidney disease. data are limited about risk factors for proteinuria in hispanic drug users with and without hiv infection. | 2008 | 18572293 |
| long-term care facilities: a cornucopia of viral pathogens. | to determine the frequency and types of respiratory viruses circulating in boston long-term care facilities (ltcfs) during a 3-year period. | 2008 | 18557966 |
| moving nursing science forward within the framework of the roy adaptation model. | in 1999, the boston-based adaptation in nursing research society associates published their analysis of roy adaptation model-based research. this earlier analysis supported the model's conceptual framework, its adaptive processes, and the influences that effect human responses. the purpose of this article is to describe more recent research within the context of the roy adaptation model's structural framework, and ongoing developments that include expanded research programs, middle-range theory ... | 2008 | 18544788 |
| perfluorinated compounds in human milk from massachusetts, u.s.a. | perfluorinated compounds (pfcs), notably perfluorooctanesulfonate (pfos) and perfluorooctanoic acid (pfoa), have been reported in human blood. furthermore, the occurrence of pfcs in the blood of newborn babies, coupled with the need to study the potential association of pfc exposure with birth outcomes in neonates, suggests the need for determining the sources and magnitude of exposure in infants. in this study, nine pfcs were measured in 45 human breast milk samples collected in 2004 from massa ... | 2008 | 18497172 |
| tipping point, over the top, or just noncompliance as usual? | 2008 | 18457226 | |
| do pediatricians manage influenza differently than internists? | little is known about how pediatricians or internists manage influenza symptoms. recent guidelines on antiviral prescribing by the centers for disease control and prevention (cdc) make almost no distinction between adults and children. our objective was to describe how pediatricians in two large academic medical institutions manage influenza and compare them to internists. | 2008 | 18435850 |
| cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. | particulate air pollution is associated with cardiovascular mortality and morbidity. to help identify mechanisms of action and protective/susceptibility factors, we evaluated whether the effect of particulate matter <2.5 mum in aerodynamic diameter (pm(2.5)) on heart rate variability was modified by dietary intakes of methyl nutrients (folate, vitamins b(6) and b(12), methionine) and related gene polymorphisms (c677t methylenetetrahydrofolate reductase [mthfr] and c1420t cytoplasmic serine hydro ... | 2008 | 18378616 |
| pediatric population size is associated with geographic patterns of acute respiratory infections among adults. | we measure the association between proportion of children and specific pediatric age groups in a local population with the timing and rate of adult emergency department (ed) utilization for influenza and other acute respiratory infections. | 2008 | 18374453 |
| social responsibility, international development, and institutional commitment: lessons from the boston university experience. | boston university (bu) has a long history of a strong social mission and commitment to service. in august 2003, bu made an institutional commitment to work with the country of lesotho to tackle the human capital implications of the hiv/aids epidemic. surrounded by south africa, and with a population of two million, lesotho, a stable democracy, suffers the world's third-highest adult hiv prevalence rate of about 24%. the initiation of the program required a substantial initial institutional inves ... | 2008 | 18303358 |
| evaluation of pathways for release of rift valley fever virus into domestic ruminant livestock, ruminant wildlife, and human populations in the continental united states. | to evaluate the feasibility for rift valley fever virus (rvfv) to enter the continental united states by various routes as well as to identify states in which domestic and wild ruminant and human populations would be most vulnerable to exposure to rvfv. | 2008 | 18279085 |
| dna sequence variants in the loxl1 gene are associated with pseudoexfoliation glaucoma in a u.s. clinic-based population with broad ethnic diversity. | pseudoexfoliation syndrome is a major risk factor for glaucoma in many populations throughout the world. using a u.s. clinic-based case control sample with broad ethnic diversity, we show that three common snps in loxl1 previously associated with pseudoexfoliation in nordic populations are significantly associated with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. | 2008 | 18254956 |
| pcb-containing wood floor finish is a likely source of elevated pcbs in residents' blood, household air and dust: a case study of exposure. | polychlorinated biphenyls (pcbs) are persistent pollutants identified worldwide as human blood and breast milk contaminants. because they bioaccumulate, consumption of meat, fish, and dairy products predicts human blood concentrations. pcbs were also used widely in building materials, including caulks and paints, but few studies have evaluated the contribution of these exposures to body burden. | 2008 | 18201376 |
| ppargc1a variation associated with dna damage, diabetes, and cardiovascular diseases: the boston puerto rican health study. | individuals with type 2 diabetes exhibit higher dna damage and increased risk of cardiovascular disease (cvd). however, mechanisms underlying the association between dna damage and development of type 2 diabetes and cvd are not understood. we sought to link peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (ppargc1a), a master transcriptional regulator of mitochondrial oxidative phosphorylation and cellular energy metabolism, with dna damage, type 2 diabetes, and cvd. | 2008 | 18162502 |
| impact of september 11 on refugees and those seeking asylum. | september 11, 2001 profoundly affected the american public. we share the views of a cohort of refugees and those seeking asylum from the boston center for refugee health and human rights. of the 63 individuals from 18 countries interviewed, many had concerns about their personal safety following september 11, as well as fears related to deportation, arrest, detention, imprisonment, discrimination, physical violence and the destruction of property, and war. asylum seekers were more likely than re ... | 2007 | 18089639 |
| using the rate of positive high-risk hpv test results for asc-us together with the asc-us/sil ratio in evaluating the performance of cytopathologists. | we reviewed our experience with 2 indicators of cytopathologist performance: the relative frequency of the interpretations atypical squamous cells of undetermined significance (asc-us) and squamous intraepithelial lesion (sil) and the frequency of positive test results for high-risk human papillomavirus (hr-hpv) dna associated with a cytologic interpretation of asc-us. data derived for 9 cytopathologists were reviewed. asc-us/sil ranged from 0.99 to 4.02 (mean, 1.77) in 2005 and from 0.82 to 3.6 ... | 2008 | 18089494 |
| charting the terrain of touch. | discusses the laboratory for human and machine haptics at the massachusetts institute of technology, nicknamed the touch lab, which investigates new technologies involved in the sense of touch. | 2000 | 18050542 |
| effect of sediment remediation on polychlorinated biphenyl concentrations in tomatoes grown near new bedford harbor. | measurements of polychlorinated biphenyl (pcb) congener concentrations and profiles from produce grown near new bedford harbor, massachusetts, usa, before, during, and after remediation of pcb-contaminated sediment are presented. samples of tomatoes collected from locations upwind and downwind relative to harbor contamination are compared with the use of measurements of 47 individual pcb congeners. the pcb concentration in the locally grown tomatoes, as expressed by the sum of congeners, is high ... | 2007 | 18046797 |
| hidde ploegh: immunologist, journeyman. interview by nicole lebrasseur. | from the moment he finished his ph.d., hidde ploegh has been a wanted man. invited to join one institution after another, he always packed with him his keen interests in the immune system. | 2007 | 17984316 |
| maternal exposure to herpes simplex virus and risk of psychosis among adult offspring. | viral exposure during gestation is thought to be a risk factor for schizophrenia. previous studies have indicated that prenatal exposure to herpes simplex virus type 2 (hsv-2) may be a risk for the subsequent development of schizophrenia in some populations. in this investigation, we tested a large and diverse population to assess the risk of psychoses among offspring of mothers with serological evidence of hsv-2 infection. | 2008 | 17981263 |