Publications

in vitro antiviral activity and preliminary clinical trials of a new adamantane compound.	a compound, 1'-methyl spiro (adamantane-2,3'-pyrrolidine) maleate, chemically related to the antiviral drug amantadine, was tested for activity in vitro against a number of human respiratory viruses. by a variety of techniques, it was shown to be active against a wide range of human and animal influenza a viruses. the effect was, however, variable and ranged from high activity against two 1957 asian strains to no observable activity against a 1971 strain. like amantadine, the drug did not inhibi ...	1973	4364762
a new virus isolated from the human respiratory tract.		1966	4285768
survival characteristics of airborne human coronavirus 229e.	the survival of airborne human coronavirus 229e (hcv/229e) was studied under different conditions of temperature (20 +/- 1 degree c and 6 +/- 1 degree c) and low (30 +/- 5%), medium (50 +/- 5%) or high (80 +/- 5%) relative humidities (rh). at 20 +/- 1 degree c, aerosolized hcv/229e was found to survive best at 50% rh with a half-life of 67.33 +/- 8.24 h while at 30% rh the virus half-life was 26.76 +/- 6.21 h. at 50% rh nearly 20% infectious virus was still detectable at 6 days. high rh at 20 +/ ...	1985	2999318
sequence analysis of the nucleocapsid protein gene of human coronavirus 229e.	human coronaviruses are important human pathogens and have also been implicated in multiple sclerosis. to further understand the molecular biology of human coronavirus 229e (hcv-229e), molecular cloning and sequence analysis of the viral rna have been initiated. following established protocols, the 3'-terminal 1732 nucleotides of the genome were sequenced. a large open reading frame encodes a 389 amino acid protein of 43,366 da, which is presumably the nucleocapsid protein. the predicted protein ...	1989	2922924
antigenic homology among coronaviruses related to transmissible gastroenteritis virus.	the antigenic homology of 26 coronavirus isolates, of which 22 were antigenically related to transmissible gastroenteritis virus (tgev), was determined with 42 monoclonal antibodies. type, group, and interspecies specific epitopes were defined. two group specific mabs distinguished the enteric tgev isolates from the respiratory variants. an antigenic subsite involved in neutralization was conserved in porcine, feline, and canine coronavirus. the classification of the human coronavirus 229e in a ...	1990	1689525
human aminopeptidase n is a receptor for human coronavirus 229e.	human coronaviruses (hcv) in two serogroups represented by hcv-229e and hcv-oc43 are an important cause of upper respiratory tract infections. here we report that human aminopeptidase n, a cell-surface metalloprotease on intestinal, lung and kidney epithelial cells, is a receptor for human coronavirus strain hcv-229e, but not for hcv-oc43. a monoclonal antibody, rbs, blocked hcv-229e virus infection of human lung fibroblasts, immunoprecipitated aminopeptidase n and inhibited its enzymatic activi ...	1992	1350662
cerebrospinal fluid antibodies to coronavirus in patients with parkinson's disease.	the etiology of parkinson's disease remains unknown, and a search for environmental agents continues. in 1985, fishman induced infection of the basal ganglia by a coronavirus in mice. although coronavirus is recognized primarily as a respiratory pathogen in humans, its affinity for the basal ganglia led us to investigate its possible role in human parkinson's disease. the cerebrospinal fluid of normal controls (ctl) (n = 18), and patients with parkinson's disease (pd (n = 20) and other neurologi ...	1992	1316552
purification and biophysical properties of human coronavirus 229e.		1976	824815
antigenic relationship of the feline infections peritonitis virus to coronaviruses of other species.	utilizing the direct and indirect fluorescent antibody procedure, the antigenic relationship of the feline infectious peritonitis virus (fipv) to 7 other human and animal coronaviruses was studied. fipv was found to be closely related to transmissible gastroenteritis virus (tgev) of swine. transmissible gastroenteritis virus and fipv were in turn antigenically related to human coronavirus 229e (hcv-229e) and canine coronavirus (ccv). an interesting finding in the study was that the 8 coronavirus ...	1978	81044