Publications

Human papillomavirus genotype distribution and human papillomavirus 16 and human papillomavirus 18 genomic integration in invasive and in situ cervical carcinoma in human immunodeficiency virus-infected women.	Women infected with human immunodeficiency virus (HIV) are at increased risk of developing precancerous and cancerous lesions in cervix because of persistence of oncogenic human papillomavirus (HPV) infection. Scarce information about the HPV genotypes attributed to cervical cancer in the HIV-infected population is available, especially in countries with a low prevalence of this pathology.	2011	21892092
project genesis: self-reported religiosity and spirituality and sexual risk-taking in young african-american women attending a historically african-american college.	this pilot study explored the relationship between self-reported religiosity, spirituality, and sexual risk-taking. the participants were a convenience sample of (n = 100) female students attending a historically african-american college (hbcu) in the south. on this predominantly female campus, students completed an anonymous health-risk survey, plus additional items, to measure their religiosity and spirituality. correlation analysis revealed that although these students reported a high degree ...	2011	21888148
[human papilloma virus and lymphatic metastasis in squamous cell carcinoma of the cervix].	our study included 112 patients with squamous cell cervical carcinoma la-lib stages (figo). all of them were restaged on the basis of histological evidence after surgical treatment. ninety-eight were staged at final analysis. human papilloma virus (hpv) was detected in endocervical smears and paraffin blocks of lymph nodes by pcr and real-time pcr. oncogenic hpv in primary tumor was detected in 86 (87.8%); two or more genotypes--65 (75.58%): still more--21 (24.4%). in the latter group, the frequ ...	2011	21882602
distribution of human papillomavirus genotypes in archival cervical tissue from women with cervical cancer in urban sri lanka.	to identify the contributions of various human papillomavirus (hpv) genotypes in tissue samples from women diagnosed with cervical cancer in sri lanka.	2011	21872246
Bacterial vaginosis and the natural history of human papillomavirus.	To evaluate associations between common vaginal infections and human papillomavirus (HPV).	2011	21869857
Treatment of HPV with hypnosis--psychodynamic considerations of psychoneuroimmunology: a brief communication.	There is increasing evidence that the hypnotic cure of warts (infection by the human papilloma virus or HPV) results from activation of an immune response, but whether this is cellular or systemic is unknown. The hypnosis can be by direct suggestion or analytical hypnotherapy when indicated. The evidence is reviewed, and 4 clinical cases suggesting cellular immune response are presented.	2011	21867375
evidence for alteration of ezh2, bmi1, and kdm6a and epigenetic reprogramming in human papillomavirus type 16 e6/e7-expressing keratinocytes.	a number of epigenetic alterations occur in both the virus and host cellular genomes during human papillomavirus (hpv)-associated carcinogenesis, and investigations of such alterations, including changes in chromatin proteins and histone modifications, have the potential to lead to therapeutic epigenetic reversion. we report here that transformed hpv16 e6/e7-expressing primary human foreskin keratinocytes (hfks) (e6/e7 cells) demonstrate increased expression of the prc2 methyltransferase ezh2 at ...	2011	21865393
efficacy of a bivalent hpv 16/18 vaccine against anal hpv 16/18 infection among young women: a nested analysis within the costa rica vaccine trial.	anal cancer remains rare (incidence of about 1·5 per 100,000 women yearly), but rates are increasing in many countries. human papillomavirus (hpv) 16 and 18 infections cause most cases of anal cancer. we assessed efficacy of an as04-adjuvanted hpv 16 and hpv 18 vaccine against anal infection with hpv 16, hpv 18, or both (hpv 16/18).	2011	21865087
[study for association between high risk human papillomavirus and cervical lesions in the samples from opportunistic screening].	to investigate the association between hpv genotypes and cervical lesion in hybrid capture 2 (hc2) hpv test positive samples.	2011	21863625
cervical cancer in the screening era: who fell victim in spite of successful screening programs?	to compare profiles of a prescreening and screening cohort of women with cervical cancer regarding histopathology and clinical variables in order to identify those remaining at risk despite successful screening programs. by analyzing these profiles we hope to improve future screening methods.	2011	21860732
human papillomavirus 16/18 as04-adjuvanted cervical cancer vaccine: immunogenicity and safety in 15-25 years old healthy korean women.	the study assessed the immunogenicity and safety of human papillomavirus (hpv)-16/18 as04-adjuvanted cervical cancer vaccine in healthy korean women aged 15-25 years.	2011	21860731
biomarkers of oxidant load and type-specific clearance of prevalent oncogenic human papillomavirus infection: markers of immune response?	human papillomavirus (hpv) infection is the cause of cervical cancer. increased production of reactive oxygen species (ros) maybe the common mechanism through which hpv-cofactors (i.e., smoking and inflammation) influence duration of infections. biomarkers of total oxidant load may serve as cumulative measures of ros exposure due to these cofactors. therefore, we conducted a study evaluating the association between biomarkers of oxidant load and duration of hpv infections, early hpv natural hist ...	2011	21858808
cervical cytology and histopathologic abnormalities in women living with aids in são paulo, brazil.	women living with hiv/aids present with a higher prevalence of human papillomavirus (hpv) infection, higher rates of squamous intraepithelial lesions, and are more susceptible to invasive cervical carcinoma progression.	2011	21857321
another look at the human papillomavirus vaccine experience in canada.	policy debates about immunization frequently focus on classic trade-offs between individual versus collective well-being. publicly funded immunization programs are usually justified on the basis of widespread public benefit with minimal individual risk. we discuss the example of the policy process surrounding the adoption of the human papillomavirus (hpv) vaccine in canada to consider whether public good arguments continue to dominate immunization policymaking. specifically, we show how a range ...	2011	21852642
human papillomavirus genotype prevalence in cervical biopsies from women diagnosed with cervical intraepithelial neoplasia or cervical cancer in fiji.	there is currently limited information about human papillomavirus (hpv) genotype distribution in women in the south pacific region. this study's objective was to determine hpv genotypes present in cervical cancer (cc) and precancers (cervical intraepithelial lesion (cin) 3) in fiji.	2011	21851773
The human papillomavirus type 16 E5 oncoprotein translocates calpactin I to the perinuclear region.	The human papillomavirus type 16 (HPV-16) E5 oncoprotein is embedded in membranes of the endoplasmic reticulum and nuclear envelope with its C terminus exposed to the cytoplasm. Among other activities, E5 cooperates with the HPV E6 oncoprotein to induce koilocytosis in human cervical cells and keratinocytes in vitro. The effect of E5 on infected cells may rely on its interactions with various cellular proteins. In this study we identify calpactin I, a heterotetrameric, Ca(2+)- and phospholipid-b ...	2011	21849434
anogenital human papillomavirus in sexually abused and nonabused children: a multicenter study.	objectives: to characterize the epidemiology of genital human papillomavirus (hpv) infection in children without previous consensual sexual activity, comparing hpv prevalence by certainty of child sexual abuse (csa). patients and methods: patients presenting for evaluation of csa in 8 sites in atlanta, houston, harrisburg, and new york city were recruited along with patients presenting for unrelated health visits. csa certainty was classified as definite, probable, possible, or no evidence follo ...	2011	21844060
colposcopy in special circumstances: pregnancy, immunocompromise, including hiv and transplants, adolescence and menopause.	the true value of colposcopy in pregnancy is under debate; the examination may be more difficult depending on the gestation at which a woman presents. cervical intraepithelial neoplasia does not have an accelerated progression during pregnancy, and treatment is usually deferred until postpartum. the prevalence of cervical intraepithelial neoplasia is greater in women with immune compromise. those with human immunodeficiency have a higher prevalence, more persistence and less regression of human ...	2011	21843974
the relationship between p16 expression and high-risk human papillomavirus infection in squamous cell carcinomas from sites other than uterine cervix: a study of 137 cases.	p16 is known to be an excellent surrogate marker of human papillomavirus infection in squamous cell carcinoma of the cervix. recent studies have demonstrated a link between human papillomavirus infection and a subset of head and neck squamous cell carcinomas, especially from the oropharynx. the aims of this study were to determine the incidence of p16 expression in squamous cell carcinomas of noncervical origin and to assess its utility as a surrogate marker of human papillomavirus infection in ...	2011	21840041
role of high-risk human papillomavirus (hpv) mrna testing in the prediction of residual disease after conisation for high-grade cervical intraepithelial neoplasia.	objective: to evaluate testing for high-risk human papillomavirus (hr hpv) e6/e7 mrna transcripts 6months after conisation for cervical intraepithelial neoplasia grade 2 or worse (cin2+) to determine the risk of residual cin2+. methods: we prospectively followed 344 women treated for cin2+ by conisation. hr hpv mrna testing (pretect hpv-proofer, norchip-«), hr hpv dna testing (amplicor hpv test, roche diagnostics-«) and cytology was performed at 6 and 12months after conisation. biopsies were tak ...	2011	21839500
factors associated with initiation and completion of the quadrivalent human papillomavirus vaccine series in an ontario cohort of grade 8 girls.	abstract: background: although over a hundred million dollars have been invested in offering free quadrivalent human papillomavirus (hpv) vaccination to young girls in ontario, there continues to be very little information about its usage. in order to successfully guide future hpv vaccine programming, it is important to monitor hpv vaccine use and determine factors associated with use in this population. methods: linking administrative health and immunization databases, we conducted a population ...	2011	21838921
economic evaluation of policy options for prevention and control of cervical cancer in thailand.	background: the thai healthcare setting has seen patients with cervical cancer experience an increasing burden of morbidity and mortality, a stagnation in the performance of cervical screening programmes and the introduction of a vaccine for the prevention of human papillomavirus (hpv) infection. objective: this study aims to identify the optimum mix of interventions that are cost effective, from societal and healthcare provider perspectives, for the prevention and control of cervical cancer. me ...	2011	21838332
high prevalence of bk polyomavirus sequences in human papillomavirus-16-positive precancerous cervical lesions.	high- and low-grade cervical lesions were analyzed for the presence of polyomavirus (pyv) and human papillomavirus (hpv) sequences. in precancerous cervical lesions, the overall prevalence of pyv sequences was 44% (41/93). specifically, among the pyv-positive samples, 83% (34/41) tested positive for bk polyomavirus (bkv) sequences, whereas 17% (7/41) were positive for jc-virus. none of the samples were positive for simian virus 40. the presence of bkv dna in high-grade squamous intraepithelial l ...	2011	21837794
targeting the human papillomavirus e6 and e7 oncogenes through expression of the bpv1 e2 protein stimulates cellular motility.	expression of the high risk human papillomavirus (hpv) e6 and e7 oncogenes is essential for the initiation and maintenance of cervical cancer. the repression of both was previously shown to result in activation of their respective tumor suppressor targets p53 and prb, and subsequent senescence induction in cervical cancer cells. consequently, viral oncogene suppression is a promising approach for the treatment of hpv positive tumors. one well established method of e6/e7 repression involves the r ...	2011	21835799
risk of seropositivity to multiple oncogenic human papillomavirus (hpv) types among hiv positive and hiv negative ugandan women.	to understand prospects for human papillomavirus (hpv) mass vaccination in a developing country setting, we studied the co-occurrence of seropositivity to multiple high-risk (hr) hpv types among hiv-positive and hiv-negative ugandan women. our sero-epidemiological study was conducted among 2053 women attending antenatal clinics. sera were analyzed for antibodies to eight hrhpv types of the alpha-7 (18/45) and alpha-9 (16/31/33/35/52/58) species of hpv using a multiplex assay. our results show th ...	2011	21832008
human papillomavirus genotype testing combined with cytology as a 'test of cure' post treatment: the importance of a persistent viral infection.	background: human papillomavirus (hpv) testing has been evaluated as a test of cure in patients following treatment of high-grade cervical intraepithelial neoplasia (cin2+). studies show that women who are hpv and cytology negative post treatment can be safely returned to routine recall. the management strategy for hpv positive women requires confirmation. objective: to evaluate the clinical utility of the papillocheck(-«) genotyping assay for predicting disease recurrence in a test of cure sett ...	2011	21831706
hpv vaccination among ethnic minorities in the uk: knowledge, acceptability and attitudes.	background:human papillomavirus (hpv) vaccination offers a unique opportunity for the primary prevention of cervical cancer. studies suggest that knowledge and attitudes about the vaccine are likely to influence uptake. one limitation of most studies assessing hpv vaccine knowledge, attitudes and acceptability is their under representation of ethnic minorities. it is important to ensure that our understanding of hpv knowledge and attitudes include all ethnic groups in the uk. this article review ...	2011	21829204
penile cancer: what's new?	this article reviews the epidemiology, diagnostic modalities and treatment of localized and advanced penile cancer, with special emphasis on most recent findings from the literature.	2011	21826001
suppression of hpv e6 and e7 expression by baf53 depletion in cervical cancer cells.	deregulation of the expression of human papillomavirus (hpv) oncogenes e6 and e7 plays a pivotal role in cervical carcinogenesis because the e6 and e7 proteins neutralize p53 and rb tumor suppressor pathways, respectively. in approximately 90% of all cervical carcinomas, hpvs are found to be integrated into the host genome. following integration, the core-enhancer element and p105 promoter that control expression of e6 and e7 adopt a chromatin structure that is different from that of episomal hp ...	2011	21821000
identification of high-risk human papillomavirus (hrhpv)-associated genes in early stage cervical squamous cell carcinomas.	this retrospective study investigated gene expression in tumour samples from 38 patients with early stage human papillomavirus (hpv)-associated cervical squamous cell carcinoma (cscc). the patients were divided into two groups based on the presence of viral markers of hpv16 or hpv18 infection. gene expression profiles of tumour samples and the corresponding normal cervical epithelium were analysed using cdna microarrays. several genes showed differential expression between the two groups of hpv- ...	2011	21819702
detection of human papillomavirus dna in urine. a review of the literature.	the detection of human papillomavirus (hpv) dna in urine, a specimen easily obtained by a non-invasive self-sampling method, has been the subject of a considerable number of studies. this review provides an overview of 41 published studies; assesses how different methods and settings may contribute to the sometimes contradictory outcomes; and discusses the potential relevance of using urine samples in vaccine trials, disease surveillance, epidemiological studies, and specific settings of cervica ...	2011	21818524
human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: a meta-analysis, 1985-2010.	human papillomavirus (hpv) types 16 and 18 are causally related to a sub-set of oral cavity and oropharyngeal squamous cell cancers. however, a clear estimate of the prevalence of hpv-16/18 in oral cavity and oropharyngeal dysplasia (oopd) is not available. this literature review and meta-analysis was conducted to provide a prevalence estimate for hpv-16/18 in oopd. twenty-two studies that reported prevalence of hpv-16 and/or 18 in 458 oopd lesions were analyzed. meta-analysis was used to evalua ...	2011	21816661
spotlight on as04-adjuvanted human papillomavirus (hpv) types 16 and 18 vaccine (cervarix-«)ôçá.	the as04-adjuvanted human papillomavirus (hpv) 16/18 vaccine (cervarix-«) is a noninfectious recombinant vaccine produced using purified virus-like particles (vlps) that induce a strong immunogenic response eliciting high levels of anti-l1 vlp antibodies that persist at levels markedly greater than those observed with natural infection. the vaccine adjuvant (as04) is composed of monophosphoryl-lipid a, which enhances cellular and humoral immune response, adsorbed to aluminum hydroxide. the vacci ...	2011	21815703
development of an as04-adjuvanted hpv vaccine with the adjuvant system approach.	a novel human papillomavirus (hpv) vaccine has been formulated with virus-like particles of the l1 protein of hpv-16 and hpv-18, and the adjuvant system 04 (as04). as04 is a combination of the toll-like receptor 4 agonist monophosphoryl lipid a (mpl) and aluminum hydroxide. the as04-adjuvanted hpv vaccine induces a high and sustained immune response against hpv, including high levels of neutralizing antibodies at the cervical mucosa in women aged 15-55 years. recently, the mechanism of action of ...	2011	21815697
inverted papilloma of the cervix and vagina: report of 2 cases of a rare lesion associated with human papillomavirus 42.	we report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting islands, trabeculae, and solid sheets of bland transitional epithelium with an inverted growth pattern. there were small foci of squamous and glandular differentiation in the cervical cas ...	2011	21813160
human papillomavirus typing of warts and response to cryotherapy.	background cutaneous warts are common and caused by a number of different types of human papillomaviruses (hpvs). objective the aim of this study was to investigate the hpv types causing common warts and to determine any association between the hpv type and the duration of warts and response to cryotherapy. methods eighty wart samples from 76 immunocompetent patients were taken from warts by paring prior to cryotherapy and analysed by in situ hybridization (ish) with hpv probes specific to hp ...	2011	21812829
characterization of a novel cutaneous human papillomavirus genotype hpv-125.	the dna genome of a novel hpv genotype, hpv-125, isolated from a hand wart of an immuno-competent 19-year old male was fully cloned, sequenced and characterized. the full genome of hpv-125 is 7,809-bp in length with a gc content of 46.4%. by comparing the nucleotide sequence of the complete l1 gene, hpv-125 is phylogenetically placed within cutaneotrophic species 2 of alphapapillomaviruses, and is most closely related to hpv-3 and hpv-28. hpv-125 has a typical genomic organization of alphapapill ...	2011	21811601
risk factors for persistent cervical intraepithelial neoplasia grades 1 and 2: managed by watchful waiting.	objective:: this study examines risk factors for persistent cervical intraepithelial neoplasia (cin) and examines whether human papillomavirus (hpv) testing predicts persistent lesions. materials and methods:: women with histologically diagnosed cin 1 or cin 2 (n = 206) were followed up every 3 months without treatment. human papillomavirus genotyping, plasma levels of ascorbic acid, and red blood cell folate levels were obtained. cervical biopsy at 12 months determined the presence of cin. rela ...	2011	21811178
development of a 2-plex luminex-based competitive immunoassay to quantify neutralizing antibodies induced by virus-like particles for human papillomavirus 16 and 18.	human papillomavirus (hpv) l1 virus-like particles (vlps) were proven an effective vaccine candidate to prevent against hpv-16 and -18 infections. in order to evaluate the potency of our produced hpv-16 and -18 l1 vlps-based vaccine candidates, also to quantify neutralizing antibodies induced by them, a 2-plex luminex-based competitive immunoassay was developed. unlike the published paper, the no-biotin conjugated neutralizing mabs spiked normal human serum (nhs) was used for standard curve prep ...	2011	21808597
development of interdigitated arrays coated with functional polyaniline/mwcnt for electrochemical biodetection: application for human papilloma virus.	in this study, polyaniline-multiwalled carbon nanotube film (pani-mwcnt) has been polymerized on interdigitated platinum electrode arrays (ida), fabricated by mems technology for the detection of human papillomavirus (hpv) infection, using immobilized peptide aptamers as affinity capture reagent. label-free, electrochemical detection of the specific immune reaction between antigen peptide aptamer hpv-16-l1 (with a molecular weight of 1825da), the most common genotype in cytological normal women ...	2011	21807222
evaluation of a novel microplate colorimetric hybridization genotyping assay for human papillomavirus.	persistent infection with high-risk human papillomavirus (hr-hpv) has been associated with cervical cancer. developing assays for the identification of these viral types is of great importance for monitoring patients and controlling strategies. the development of the mcha (microplate colorimetric hybridization assay), a pcr-based method for identifying six of the most common hr-hpv types (hpv 16, 18, 31, 33, 39 and 45) is described. the mcha combines the amplification with the gp5+/gp6+ consensu ...	2011	21807028
expression of p16 in sinonasal undifferentiated carcinoma (snuc) without associated human papillomavirus (hpv).	sinonasal undifferentiated carcinoma (snuc) is an uncommon and highly aggressive neoplasm of the paranasal sinuses and nasal cavity. its undifferentiated histologic appearance often requires immunohistochemical studies to distinguish it from other high-grade neoplasms. due to the rarity of snuc, its immunohistochemical staining profile has been incompletely characterized, and little work has been done on its expression of the markers for human papillomavirus (hpv). our objective is to expand our ...	2011	21805120
chemotherapeutic alteration of vegf-/pdgf- and pdgf-ra/ß expression by imatinib in hpv-transformed squamous cell carcinoma compared to hpv-negative hnscc in vitro.	head and neck squamous cell carcinoma (hnscc) is an aggressive epithelial malignancy known to be the most common neoplasm appearing in the upper aerodigestive tract. the poor five-year survival rate has remained unchanged in the last decades despite the emergence of improved techniques in surgery, radiation and chemotherapy. in the last 20 years awareness of a subset of squamous cell carcinomas induced by oncogenic forms of the human papilloma virus (hpv) (high-risk types 16 and 18) has increase ...	2011	21805039
evaluating a county-sponsored social marketing campaign to increase mothers' initiation of hpv vaccine for their pre-teen daughters in a primarily rural area.	routine vaccination against human papillomavirus (hpv), the main cause of cervical cancer, is recommended for 11-12 year old girls, yet vaccine uptake is low. this study evaluates a social marketing campaign initiated by 13 north carolina counties to raise awareness among parents and reduce barriers to accessing the vaccine in a primarily rural area. the 3-month campaign targeted mothers of girls ages 11-12 and healthcare practices serving pre-teen girls in four counties. principles of social ma ...	2011	21804767
high-risk human papillomavirus is associated with hiv acquisition among south african female sex workers.	background. mounting evidence suggests an association between human papillomavirus (hpv) and hiv acquisition. this study aimed to explore this association among south african female sex workers (fsws). methods. we used data from 88 hiv-negative fsws who participated in a vaginal gel (col-1492) trial. cervicovaginal rinse samples, obtained before hiv-seroconversion, were genotyped into high-risk (hr-) and low-risk (lr-) hpv. hiv-adjusted hazard ratios (ahrs) and 95% confidence intervals (ci) were ...	2011	21804752
role of via in cervical cancer screening in low-resource countries.	cervical cancer is one of the few highly preventable cancers. the early detection and removal of precancerous cervical lesions effectively abolish the development of invasive cervical cancer. the pap test has been the standard screening test in the western world for the last five decades. visual inspection of cervix with acetic acid (via) is currently more popular method of cervical cancer of screening test in low resource countries. cervical cancer incidence and mortality have been reduced dram ...	2011	21804524
human papillomavirus genotyping by 454 next generation sequencing technology.	background: an accurate tool for human papillomavirus (hpv) typing is important both for management of patients with hpv infection and for surveillance studies. objectives: design and evaluation of an hpv typing method based on 454 next generation sequencing (ngs) technology. study design: development of an hpv typing method based on 454 ngs of hpv l1 amplicons generated with my09/11-based primers. evaluation of the ngs method in control samples and in a panel of cervical cytological samples. co ...	2011	21802982
pre-vaccination genomic diversity of human papillomavirus genotype 6 (hpv 6): a comparative analysis of 21 full-length genome sequences.	comparative analysis of 21 full-length genome sequences of human papillomavirus genotype 6 (hpv 6): 18 determined in this study and three sequences available in nucleotide sequence databases, revealed more than 98% nucleotide similarity to the hpv 6 prototype isolate. the minimum and maximum genomic distance between the full-length genomic variants and the prototype sequence was three nucleotide substitutions, and 122 nucleotide substitutions and three insertions, respectively. detailed sequence ...	2011	21801853
safety and immunogenicity of human papillomavirus-16/18 as04-adjuvanted vaccine in healthy chinese females aged 15 to 45 years: a phase i trial.	globally, about 70% of cervical cancers are associated with human papillomavirus (hpv)-16 or hpv-18 infection. a meta-analysis of epidemiologic studies in china showed that hpv was present in 98% of cervical cancer samples. the hpv-16/18 as04-adjuvanted vaccine cervarix has shown a high level of protection against hpv-16/18 infections and associated cervical lesions. this phase i trial (nct00549900) assessed the safety, tolerability, and immunogenicity of the vaccine in chinese. thirty healthy c ...	2011	21801604
a population-based, cross-sectional study of age-specific risk factors for high risk human papillomavirus prevalence in rural nigeria.	abstract: background: cervical cancer, caused by persistent infection with carcinogenic human papillomavirus (hr-hpv), is particularly prevalent in sub-saharan africa and is associated with a high mortality rate. some studies in west africa, including our own, have found unusually high hr-hpv across all ages with a slight peak in older women. this increased prevalence may complicate screen-and-treat programs, which are implemented in regions where hpv prevalence declines with age and typically t ...	2011	21801395
exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in notch1.	head and neck squamous cell carcinoma (hnscc) is the sixth most common cancer worldwide. to explore the genetic origins of this cancer, we used whole-exome sequencing and gene copy number analyses to study 32 primary tumors. tumors from patients with a history of tobacco use had more mutations than did tumors from patients who did not use tobacco, and tumors that were negative for human papilloma virus (hpv) had more mutations than did hpv-positive tumors. six of the genes that were mutated in m ...	2011	21798897
lymphoepithelial-like carcinoma of the uterine cervix; a case report.	lymphoepithelioma-like carcinoma (lelc) of the uterine cervix is a rare variant of squamous cell carcinoma of the uterine cervix. this tumor is characterized by nests of poorly differentiated epithelial cells surrounded by a prominent lymphocytic infiltration. despite the poorly differentiated pathological findings, it appears to have a better outcome than the usual squamous cell carcinoma of the uterine cervix. therefore, it is quite important to differentiate this tumor from poorly differentia ...	2011	21797126
immunological evaluation of vaginal secretion in patients with high-grade cervical intraepithelial neoplasia treated with intralesional interferon alpha-2b.	conservative treatment with intralesional interferon (ifn) is a therapeutic option for cervical intraepithelial neoplasia (cin) patients of childbearing age.	2011	21797121
xrcc1 arg399gln polymorphism and risk for cervical cancer development in argentine women.	xrcc1 (x-ray repair cross-complementing group 1) plays a central role in the dna base excision repair mechanism. single nucleotide polymorphisms (snps) in the xrcc1 gene are thought to modulate dna repair capacity and have been linked to cancer risk in several studies.	2011	21797115
pre-vaccination epidemiology of human papillomavirus infections in japanese women with abnormal cytology.	aim: to investigate the pre-vaccination epidemiology of genital human papillomavirus (hpv) infections and genotypes in women with abnormal cytology in nagasaki, japan. material and methods: we performed pap smear tests, biopsies and hpv genotype testing in nagasaki prefecture from august 2007 through november 2009. results: during the study period, serial samples of uterine cervical specimens were obtained from 539 subjects with abnormal cytology and/or squamous intraepithelial lesions (sil) ...	2011	21793993
usefulness of serum mass spectrometry to identify women diagnosed with higher grades of cervical intraepithelial neoplasia may differ by race.	an early detection of precursor lesions of cervical cancer will help to eliminate the worldwide burden of cervical cancer.	2011	21792340
screening for the prevention of cervical cancer in the era of human papillomavirus vaccination: an australian perspective.	australia has a unique and highly successful screening program for cervical cancer which is based on the conventional pap smear. since its introduction in 1991 there has been a decline in both the incidence of and mortality from this disease. part of the success of this program has been the introduction of pap test registers and strict quality assurance measures for cervical cytology, including compulsory key performance indicators for laboratories. using these measures, nationwide calculations ...	2011	21791898
prevalence of genital human papillomavirus among females in the united states, the national health and nutrition examination survey, 2003-2006.	background. genital human papillomaviruses (hpv) include >40 sexually transmitted viruses. most hpv infections do not progress to disease, but infection with certain types of hpv can cause cervical and other anogenital and oropharyngeal cancer, and other types of hpv are associated with anogenital warts. hpv vaccines prevent infection with hpv 16 and 18, which account for 70% of cases of cervical cancer, and hpv 6 and 11, which cause 90% of the cases of anogenital warts. methods. using data an ...	2011	21791659
human papillomavirus type 16 e6 inhibits p21(waf1) transcription independently of p53 by inactivating p150(sal2).	hpv16 e6 deregulates g1/s cell cycle progression through p53 degradation preventing transcription of the cdk inhibitor p21(waf1). however, additional mechanisms independent of p53 inactivation appear to exist. here, we report that hpv16 e6 targets the cellular factor p150(sal2), which positively regulates p21(waf1) transcription. hpv16 e6 associates with p150(sal2), inducing its functional inhibition by preventing its binding to cis elements on the p21(waf1) promoter. a hpv16 e6 mutant, l110q, w ...	2011	21791360
psychological responses of women infected with cervical human papillomavirus: a qualitative study in taiwan.	to determine the psychological response of cervical human papillomavirus (hpv) infected women.	2011	21791300
integration of human papillomavirus correlates with high levels of viral oncogene transcripts in cervical carcinogenesis.	a prospective, cross-sectional study was conducted to investigate the correlation between the integration of high-risk human papillomavirus and disease severity of cervical lesions. 720 liquid-based cytology specimens including 422 normal cytology, 78 low-grade squamous intraepithelial lesions, 172 high-grade squamous intraepithelial lesions, and 48 women with cervical cancers were examined using hpv blot and type-specific e6 pcr. positive hpv dna types 16, 18, 52 and 58 were examined for viral ...	2011	21777630
emerging theme: cellular pdz proteins as common targets of pathogenic viruses.	more than a decade ago three viral oncoproteins - adenovirus type 9 e4-orf1, human t-lymphotropic virus type 1 tax, and high-risk human papillomavirus e6 - were found to encode a related carboxyl-terminal pdz domain-binding motif (pbm) that mediates interactions with a select group of cellular pdz proteins. recent studies have shown that many other viruses also encode pbm-containing proteins that bind to cellular pdz proteins. interestingly, these recently recognized viruses include not only som ...	2011	21775458
histopathologic follow-up and human papillomavirus dna test results in 290 patients with high-grade squamous intraepithelial lesion papanicolaou test results.	background: the study documents histopathologic outcomes and high-risk (hr) human papillomavirus (hpv) test results in a large cohort of patients with high-grade squamous intraepithelial lesion (hsil) liquid-based cytology (lbc) pap test results. methods: a total of 352 patients with hsil results (338 cervical and 14 vaginal) who had hrhpv testing and 290 patients with biopsy follow-up were studied. hrhpv detection rates were compared at different ages, with or without an endocervical/transforma ...	2011	21774093
incomplete knowledge - unclarified roles in sex education: results of a national survey about human papillomavirus infections.	marek e., dergez t., bozsa s., gocze k., rebek-nagy g., kricskovics a., kiss i., ember i. & gocze p. (2011) european journal of cancer care. incomplete knowledge - unclarified roles in sex education: results of a national survey about human papillomavirus infections the purpose of this study was to evaluate the awareness of human papillomavirus (hpv) infections both in male and female adults in hungary. a self-administered, anonymous questionnaire was completed by 785 college students and parent ...	2011	21771125
small molecule inhibitors of human papillomavirus protein - protein interactions.	human papillomaviruses (hpv) have now been identified as a necessary cause of benign and malignant lesions of the differentiating epithelium, particularly cervical cancer, the second most prevalent cancer in women worldwide. while two prophylactic hpv vaccines and screening programs are available, there is currently no antiviral drug for the treatment of hpv infections and associated diseases. the recent progress toward the identification and characterization of specific molecular targets for sm ...	2011	21769307
the first international standard for antibodies to hpv 16.	current hpv vaccines and vaccine candidates are based on recombinant virus capsid proteins, so called virus-like particles (vlps). standardisation of assays for hpv capsid antibody will assist with epidemiology studies and future vaccine development. a world health organization international collaborative study was undertaken to assess the suitability of a freeze-dried serum, obtained from women naturally infected with hpv 16 and reactive against hpv 16 only, to serve as the international standa ...	2011	21767589
human papillomavirus genotype distribution in czech women and men with diseases etiologically linked to hpv.	the hpv prevalence and genotype distribution are important for the estimation of the impact of hpv-based cervical cancer screening and hpv vaccination on the incidence of diseases etiologically linked to hpvs. the hpv genotype distribution varies across different geographical regions. therefore, we investigated the type-specific hpv prevalence in czech women and men with anogenital diseases.	2011	21765924
new human papillomavirus (hpv) types involved in epidermodysplasia verruciformis (ev) in 3 hiv-infected patients: response to topical cidofovir.		2011	21763546
skin tumor formation in human papillomavirus 8 transgenic mice is associated with a deregulation of oncogenic mirnas and their tumor suppressive targets.	background: dysregulation of microrna (mirna) expression is regularly found in various types of cancer and contributes to tumorigenic processes. however, little is known about mirna expression in non-melanoma skin cancer in which a pathogenic role of beta human papillomaviruses (hpv) is discussed. a carcinogenic potential of beta hpv8 could be demonstrated in a transgenic mouse model, expressing all early genes of hpv8 (hpv8-cer). a single uva/b-dose induced oncogene expression and led to papill ...	2011	21763111
human papillomavirus type 18 chimeras containing the l2/l1 capsid genes from evolutionarily diverse papillomavirus types generate infectious virus.	papillomaviruses (pvs) comprise a large family of viruses infecting nearly all vertebrate species, with more than 100 human pvs identified. our previous studies showed that a mutant chimera hpv18/16 genome, consisting of the upper regulatory region and early orfs of hpv18 and the late orfs of hpv16, was capable of producing infectious virus in organotypic raft cultures. we were interested in determining whether the ability of this chimeric genome to produce infectious virus was the result of hpv ...	2011	21762735
higher incidence and persistence of high-risk human papillomavirus infection in female sex workers compared with women attending family planning.	background: there are no data on the incidence and persistence of high-risk human papillomavirus (hr-hpv) infections in female sex workers (fsws). we aimed to describe and compare the rates of incidence and persistence of hr-hpv infections in fsws and women from the general population (wgp) who attended healthcare facilities between may 2003 and december 2006 in alicante, spain. methods: women with an established hr-hpv infection at study entry were evaluated for the analysis of hr-hpv persisten ...	2011	21757383
human papillomavirus: science and technologies for the elimination of cervical cancer.	introduction: academic research has made a significant advancement in understanding the viral causes of cervical cancer and generating the technology for prevention, both at the primary and secondary levels. human papillomaviruses (hpvs) have been recognized as the first necessary cause of cervical cancer, the second most common cancer in women worldwide. areas covered: this paper reviews the epidemiological evidence of the causality of hpv in relation to cervical cancer, other genital tract can ...	2011	21756205
self-sample hpv-tests as an intervention for non-atteendees of cervical cancer screening in finland: a randomised study.	background: attendance in screening is an important determinant of cervical cancer. previous experience on high-risk human papillomavirus (hrhpv) dna testing on patient-obtained samples suggests a good effect among non-attendees of screening. we assessed the effects of self-sampling on attendance in the finnish screening programme.methods: non-attendees after the primary invitation in one municipality (espoo) were randomised to receive either a self-sampling kit (2,397 women) or an extra invitat ...	2011	21752985
incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients.	abstract: background: renal allograft recipients are reported to have a higher incidence of malignancy than the general population. this single hospital-based study examined the incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients. methods: among 453 women receiving renal transplantation from january 1990 to december 2008, 5 patients were diagnosed with cervical carcinoma. medical records of these 5 patients were retrospectively reviewed, and clin ...	2011	21752252
oral hpv infection and sexuality: a cross-sectional study in women.	human papillomavirus (hpv) is the main risk factor for cervical cancers and is associated with close to 36% of oropharyngeal cancers. there is increasing evidence that oral hpv transmission is related to sexual behavior but to our knowledge studies that involve women who have sex with women have not been performed. we examined the prevalence of oral hpv according to sexual behavior among a population-based sample of 118 women and have made some inferences of possible predictors of oral hpv infec ...	2011	21747715
an examination of male and female odds ratios by bmi, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies.	greater tobacco smoking and alcohol consumption and lower body mass index (bmi) increase odds ratios (or) for oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ors for these factors.	2011	21744095
until which age should women be vaccinated against hpv infection? recommendation based on cost-effectiveness analyses.	cervical cancer is caused by infection with human papillomavirus (hpv). several countries have implemented vaccination programs against hpv for teenage girls before sexual debut. however, recent clinical trials have demonstrated that vaccination of older women is highly effective as well. accordingly, it has been suggested that these older women should also be offered vaccination. here, the cost-effectiveness of hpv vaccination for older women was assessed.	2011	21742836
incremental impact of adding boys to current human papillomavirus vaccination programs: role of herd immunity.	our aim was to examine the potential incremental impact of vaccinating boys against human papillomavirus (hpv) on vaccine-type infection in females and males, using an individual-based hpv transmission-dynamic model. under base assumptions (vaccine efficacy = 99%, duration of protection = 20 years, coverage = 70%), vaccinating 12-year-old boys, in addition to girls, resulted in an incremental reduction in hpv-16/18 (hpv-6/11) incidence over 70 years of 16% (3%) in females and 23% (4%) in males. ...	2011	21742835
human papillomavirus serologic follow-up response and relationship to survival in head and neck cancer: a case-comparison study.	abstract:	2011	21740566
a semliki forest virus vector engineered to express ifn+¦ induces efficient elimination of established tumors.	semliki forest virus (sfv) represents a promising gene therapy vector for tumor treatment, because it produces high levels of recombinant therapeutic proteins while inducing apoptosis in infected cells. in this study, we constructed a sfv vector expressing murine interferon alpha (ifn+¦). ifn+¦ displays antitumor activity mainly by enhancing an antitumor immune response, as well as by a direct antiproliferative effect. in spite of the antiviral activity of ifn+¦, sfv-ifn could be produced in bhk ...	2011	21734727
cervical cancer treatment in africa.	this review is to inform the reader about the current situation with regard to treatment of cervical cancer in africa and the barriers and complexities faced in most african countries. it also reviews the natural history of cervical cancer, the new 2009 international federation of gynecology and obstetrics staging, and current treatment guidelines for cervical cancer.	2011	21734579
the changing picture of high-grade anal intraepithelial neoplasia in men who have sex with men: the effects of 10 years of experience performing high-resolution anoscopy.	ten years ago, we published findings from anal dysplasia screening in a metropolitan surgical practice where the majority of men who have sex with men had biopsy-proven high-grade anal intraepithelial neoplasia.	2011	21730790
induction of human +¦-defensins and psoriasin in vulvovaginal human papillomavirus-associated lesions.	infections with a low-risk type of human papillomavirus (hpv) may lead to genital warts. hpv targets the basal cell layer of epithelial cells. the first line of defense is the innate immune system, which provides nonspecific protection against a variety of pathogens. the antimicrobial peptides (amps) +¦- and +¦-defensins, cathelicidins, psoriasin, and rnase7 are central mediators.	2011	21730203
human papillomavirus vaccination uptake and factors related to uptake in a traditional desert city in the united arab emirates.	it is important to assess uptake of a new vaccine. the present survey estimated the uptake of the recently introduced human papillomavirus vaccine (hpvv) in the emirate of abu dhabi and also explored barriers to uptake. a questionnaire survey was conducted in secondary schools, enrolling 334 girls. the uptake percentage was estimated and factors associated with uptake were assessed with multilevel logistic regression. crude vaccination uptake was 53%. factors positively associated with uptake we ...	2011	21729960
a randomized clinical comparative study of cryotherapy plus photodynamic therapy vs. cryotherapy in the treatment of multiple condylomata acuminata.	cryotherapy cannot destroy subclinical human papillomavirus-infected cells of condylomata acuminata (ca). the topical application of aminolevulinic acid (ala) results in a shallow penetration depth in ca lesions (1).	2011	21729164
Promoter methylation analysis of WNT/+¦-catenin signaling pathway regulators to detect adenocarcinoma or its precursor lesion of the cervix.	Cervical adenocarcinoma (AdCA) and adenocarcinoma in situ (ACIS) are frequently missed in cytology-based screening programs. Testing for high-risk human papillomavirus (hrHPV) improves their detection, but novel ACIS/AdCA specific biomarkers are needed to increase specificity for these lesions. Novel markers may be deduced from the WNT/+¦-catenin signaling pathway, which is aberrantly activated during cervical carcinogenesis.	2011	21726894
prevalence of human papillomavirus (hpv) types in cervical cancer 2003-2008 in stockholm, sweden, before public hpv vaccination.	abstract background. human papillomavirus (hpv) infection is the major cause of cervical cancer, but the prevalence of different hpv types varies depending on geographical location and may change dramatically after introduction of hpv vaccination. here, we aimed to gain some information regarding the recent prevalence of different hpv types, in cancer of the uterine cervix in the stockholm region, before the introduction of public hpv vaccination in sweden. material and methods. from 215 diagnos ...	2011	21726177
rate of detection of high-risk hpv with two assays in womenôëñ30years of age.	high-risk (hr) human papillomavirus (hpv) prevalence rates, as determined by the cervista(-«) hpv hr test, in women aged ôëñ30 years in a routine screening population have not been studied.	2011	21724457
human papillomavirus genotypes in male genitalia and their concordance among pregnant spouses participating in the finnish family hpv study.	introduction.ôçé genotype-specific concordance among human papillomavirus (hpv)-infected spouses is incompletely assessed. hpv concordance is of importance in counselling hpv-infected subjects and their partners. aim.ôçé to determine hpv-genotype distribution and prevalence in semen and urethral samples of young fathers and their concordance with hpv-genotypes in cervical and oral mucosal samples of their spouses. methods.ôçé in the finnish family hpv study, urethral and semen samples were colle ...	2011	21718450
high-risk hpv dna testing and hpv-16/18 genotyping: what is the clinical application?	there are currently 2 tests approved for clinical use that nonspecifically detect the presence of multiple oncogenic or high-risk human papillomavirus (hpv) types. one hpv genotyping test is also available for use that specifically detects the presence of high-risk hpv types 16 and 18. the purpose of this review was to evaluate the clinical performance of these hpv dna tests and the utility of the tests within current screening recommendations.	2011	21716051
p63 is necessary for the activation of human papillomavirus late viral functions upon epithelial differentiation.	the late phase of the human papillomavirus (hpv) life cycle is linked to epithelial differentiation, and we investigated the factors that regulate this process. one potential regulator is p63, a member of the p53 family of proteins, which modulates epithelial development, as well as proliferation capability, in stem cells. in this study, we examined the role of p63 in the hpv life cycle using a lentiviral knockdown system for p63. in epithelial cells, the δn truncated isoforms of p63 predominate ...	2011	21715473
mother-daughter communication and college women's confidence to communicate with family members and doctors about the human papillomavirus and sexual health.	in this study, we examined whether mother-daughter sexuality communication in midadolescence contributes to young women's self-efficacy to consult with family members about sexual health problems, and to talk with physicians about the human papillomavirus (hpv).	2011	21715198
dendritic cell subsets and immunological milieu in inflammatory human papilloma virus-related skin lesions.	human papilloma virus (hpv)-related warts persist, evading host immune surveillance, but sometimes disappear with inflammation.	2011	21715145
safety and reactogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, 18) l1 viral-like-particle vaccine in older adolescents and young adults.	prophylactic vaccination with a quadrivalent hpv (types 6, 11, 16, 18) vaccine (qhpv) has been shown to prevent infection with hpv 6/11/16/18 and associated disease in women and more recently, in men. here we report on the safety and reactogenicity of the qhpv vaccine in males. a total of 4,065 healthy males aged 16-26 years were enrolled into a randomized, placebo-controlled, double-blind trial. subjects were randomized 1:1 to receive qhpv vaccine or placebo at day 1, month 2, and month 6. safe ...	2011	21712645
the value of high-resolution anoscopy in the diagnosis of anal cancer precursor lesions in hiv-positive patients.	anal cancer, although a still rare disease, is being observed in ascending rates among some population segments known to be at risk for the development of the disease. human papillomavirus (hpv) infection, immunodepression and anal intercourse are some factors associated with the development of the malignancy. its similarities to cervical cancer have led to many studies aiming to establish guidelines for detecting and treating precursor lesions of anal cancer, with the goal of prevention. high-r ...	2011	21709956
see-and-treat approaches to cervical cancer prevention for hiv-infected women.	cervical cancer remains the second commonest cancer among women worldwide, and more than 85% of the global burden of this disease occurs in the developing world. hiv-infected women have a higher likelihood of developing persistent high-risk human papillomavirus (hpv) infection, precancer, and invasive cervical cancer than seronegative women. although highly effective primary and secondary prevention strategies are currently available, they remain inaccessible to the vast majority of women. becau ...	2011	21706187
efficient dna extraction for hpv genotyping in formalin-fixed, paraffin-embedded tissues.	dna from archived ffpe can be used for papillomavirus genotyping, but potential problems include paraffin as a physical barrier, dna cross-linking, and pcr inhibitors. to address these complications, we combined a commercially available dna isolation kit (qiagen dneasy) with a heat treatment and evaluated the resulting dna with regards to hpv typing. dna was extracted from 10-++m sections from 150 ffpe cancer samples. one protocol followed the manufacturer's recommendation, including paraffin re ...	2011	21704270
c-t variant in a mirna target site of bcl2 is associated with increased risk of human papilloma virus related cervical cancer-an in silico approach.	micrornas control gene expression at the posttranscriptional level by base-pairing to the 3'-utr of their target mrnas, thus leading to mrna degradation of protein fabrication. we hypothesize, snps within mirnas and their targets could be of significance to an individual's risk of developing cancer. we analyzed in silico snp information on cervical cancer associated aberrant alleles and further investigated this in a case-control study by examining eleven snps from different genes. it was observ ...	2011	21704150
performance of the quantitative food frequency questionnaire used in the brazilian center of the prospective study natural history of human papillomavirus infection in men: the him study.	the natural history of human papillomavirus (hpv) infection in men: the him study is a prospective multicenter cohort study that, among other factors, analyzes participants' diet. a parallel cross-sectional study was designed to evaluate the validity and reproducibility of the quantitative food frequency questionnaire (qffq) used in the brazilian center from the him study. for this, a convenience subsample of 98 men aged 18 to 70 years from the him study in brazil answered three 54-item qffq and ...	2011	21703383
alaska native adolescent views on cervical cancer, the human papillomavirus (hpv), genital warts and the quadrivalent hpv vaccine.	to understand the knowledge levels, attitudes and perceptions of alaska native adolescent girls about cervical cancer, hpv, genital warts and the hpv vaccine.	2011	21703130