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[the characteristics of a cholera outbreak in pushkino district, the azerbaijan ssr].the outbreak of cholera in the pushkino district of the azerbaijan ssr, caused by the penetration of vibrio cholerae into the water of the irrigation system, is described. altogether 2 cholera patients and 39 vibrio carriers were detected. the etiological agent of this infection was v. cholerae eltor, serovar ogawa, with typical phenotype characteristics. from all patients and 37 carriers virulent strains and from 2 carriers faintly virulent strains were isolated. in this outbreak family foci we ...19911831949
limitations of balloon angioplasty for vein graft stenosis.vein graft stenosis remains an important contributing factor to the failure of infrainguinal arterial reconstruction. repair of these lesions before graft occlusion provides sustained patency, yet the optimal method of repair has not been established. percutaneous transluminal balloon angioplasty of these vein graft lesions has been repeatedly advocated as an alternative to surgical revision. balloon angioplasty was used in 30 patients with 54 stenotic lesions occurring in autogenous vein grafts ...20071831863
peritoneal macrophage response: an in vivo model for the study of synthetic materials.this study was designed to validate an in vivo model in rat to study cell-implant interactions. pieces of dacron and goretex and polydimethylsiloxane (reference material) precoated or not were implanted in the peritoneal cavity. in some cases the peritoneal cells were stimulated before the implantation. macrophage phagocytosis and fibrinocoagulolytic activities were investigated in parallel with morphological studies 6 h after implantation. a graded cell response related to the different situati ...19911831674
peritoneal macrophage response: an in vivo model for the study of synthetic materials.this study was designed to validate an in vivo model in rat to study cell-implant interactions. pieces of dacron and goretex and polydimethylsiloxane (reference material) precoated or not were implanted in the peritoneal cavity. in some cases the peritoneal cells were stimulated before the implantation. macrophage phagocytosis and fibrinocoagulolytic activities were investigated in parallel with morphological studies 6 h after implantation. a graded cell response related to the different situati ...19911831674
mercuric chloride-induced inhibition of different atpases in the intestine of mudskipper, boleophthalmus dentatus.this paper deals with the toxicity of mercuric chloride to different atpases in the intestine of mudskipper (boleophthalmus dentatus). mudskippers were exposed to four sublethal concentrations of mercuric chloride for three durations. the specific activities of na+, k(+)-atpase, ca(2+)-atpase, mg(2+)-atpase, ca2+, hco3(-)-atpase, and mg2+, hco3(-)-atpase were estimated. there was linear inhibition of all the enzymes with increasing mercuric chloride concentration as well as exposure duration. th ...20071829408
first trimester ca 125 and down's syndrome. 20071829379
[lung worm on a farm with summer stable feed]. 19911829278
percutaneous transjugular portosystemic shunt.--to determine the effectiveness of the palmaz balloon expandable stent for the creation of a transjugular intrahepatic portosystemic shunt. the device is designed to achieve portal decompression in patients with variceal hemorrhage secondary to portal hypertension.20071829120
exposure to human immunodeficiency virus (hiv) type i indicated by hiv-specific t helper cell responses before detection of infection by polymerase chain reaction and serum antibodies [corrected].a healthy individual at risk for human immunodeficiency virus type 1 (hiv-1) infection was studied longitudinally for 19 months for evidence of exposure to and infection with hiv. peripheral blood mononuclear cells (pbmc) were tested at 1, 5, 13, 16, and 19 months for t helper (th) cell function by in vitro-generated proliferation and interleukin-2 production in response to four synthetic peptides corresponding to env of hiv. pbmc were also tested for proviral dna using gag primers by the polyme ...19911829105
exposure to human immunodeficiency virus (hiv) type i indicated by hiv-specific t helper cell responses before detection of infection by polymerase chain reaction and serum antibodies [corrected].a healthy individual at risk for human immunodeficiency virus type 1 (hiv-1) infection was studied longitudinally for 19 months for evidence of exposure to and infection with hiv. peripheral blood mononuclear cells (pbmc) were tested at 1, 5, 13, 16, and 19 months for t helper (th) cell function by in vitro-generated proliferation and interleukin-2 production in response to four synthetic peptides corresponding to env of hiv. pbmc were also tested for proviral dna using gag primers by the polyme ...19911829105
the concept of major depression. ii. agreement between six competing operational definitions in 600 psychiatric inpatients.six operational definitions of the concept of major depression were submitted to empirical evaluation in 600 psychiatric inpatients. special attention was given to the comparison of major depression in dsm-iii-r and icd-10. the data base created by a polydiagnostic interview revealed relevant classificatory differences between the six definitions under study. sources of different diagnostic base rates were: inclusion or omission of anhedonia as an obligatory mood criterion; minimal number of syn ...20061829001
the concept of major depression. ii. agreement between six competing operational definitions in 600 psychiatric inpatients.six operational definitions of the concept of major depression were submitted to empirical evaluation in 600 psychiatric inpatients. special attention was given to the comparison of major depression in dsm-iii-r and icd-10. the data base created by a polydiagnostic interview revealed relevant classificatory differences between the six definitions under study. sources of different diagnostic base rates were: inclusion or omission of anhedonia as an obligatory mood criterion; minimal number of syn ...20061829001
aggressive chemotherapy for acute leukaemia frequently causes intestinal protein leakage.cytostatic drugs are known to produce disturbances in intestinal absorption of carbohydrates. to further explore the gastrointestinal (gi) toxicity of cytostatic therapy, 37 patients with acute leukemia were investigated during and/or after remission induction courses by the use of the differential sugar absorption test (dsat) and the intestinal clearance of alpha-1-antitrypsin (claat). the ratio of the lactulose to the mannitol excretion in the urine was found abnormal in 44% of the tests. the ...20061828960
aggressive chemotherapy for acute leukaemia frequently causes intestinal protein leakage.cytostatic drugs are known to produce disturbances in intestinal absorption of carbohydrates. to further explore the gastrointestinal (gi) toxicity of cytostatic therapy, 37 patients with acute leukemia were investigated during and/or after remission induction courses by the use of the differential sugar absorption test (dsat) and the intestinal clearance of alpha-1-antitrypsin (claat). the ratio of the lactulose to the mannitol excretion in the urine was found abnormal in 44% of the tests. the ...20061828960
similarity of the three-dimensional structures of actin and the atpase fragment of a 70-kda heat shock cognate protein.although there is very little sequence identity between the two proteins, the structures of rabbit skeletal muscle actin (375-amino acid residues) and the 44-kda atpase fragment of the bovine 70-kda heat shock cognate protein (hsc70; 386 residues) are very similar. the alpha-carbon positions of 241 pairs of amino acid residues that are structurally equivalent within the two proteins can be superimposed with a root-mean-square difference in distance of 2.3 a; of these, 39 residues are identical, ...19911828889
structure of the rabbit phospholamban gene, cloning of the human cdna, and assignment of the gene to human chromosome 6.we have isolated and characterized genomic dna clones encoding rabbit phospholamban. only a single gene for phospholamban was detected in the rabbit genome. the phospholamban gene of 13.2 kilobases contains only one 10.5-kilobase intron, which separates exonic sequences located in the 5'-untranslated region. two potential transcription initiation sites were mapped to 335 and 185 nucleotides upstream from the translation initiation site in the mrna or 239 and 89 nucleotides upstream from the exon ...19911828805
retinal neurite growth on astrocytes is not modified by extracellular matrix, anti-l1 antibody, or oligodendrocytes.two factors that may influence the course of axonal regeneration in the central nervous system (cns) are extracellular matrix (ecm) and cell surface molecules that may enhance or inhibit neurite outgrowth. whereas cultured astrocytes have been reported to be a good substratum for neurite outgrowth, there is recent evidence that cultured oligodendrocytes are inhibitory. to test the influences of 1) ecm components, 2) the l1 adhesion molecule, and 3) the inhibitory potential of mature oligodendroc ...19911828788
retinal neurite growth on astrocytes is not modified by extracellular matrix, anti-l1 antibody, or oligodendrocytes.two factors that may influence the course of axonal regeneration in the central nervous system (cns) are extracellular matrix (ecm) and cell surface molecules that may enhance or inhibit neurite outgrowth. whereas cultured astrocytes have been reported to be a good substratum for neurite outgrowth, there is recent evidence that cultured oligodendrocytes are inhibitory. to test the influences of 1) ecm components, 2) the l1 adhesion molecule, and 3) the inhibitory potential of mature oligodendroc ...19911828788
surveys of human enterotoxigenic escherichia coli from three different geographical areas for possible colonization factors.enterotoxigenic escherichia coli (etec) from burma, central africa (rwanda and zaire) and peru, were screened by enzyme-linked immunoassays for the colonization factor antigens (cfas) and putative colonization factors (pcfs): cfa/i, cfa/ii, which consists of three coli surface-associated (cs) antigens, cs1, cs2 and cs3, cfa/iii, cfa/iv (cs4, cs5, cs6), cs7, pcfo9, pcfo159. h4, pcfo166, and cs17. the highest proportion of etec with identifiable colonization factors (71%) were found in the strains ...19911828771
issues with radiation therapy article. 20061828682
issues with radiation therapy article. 20061828682
the use of potassium-titanyl-phosphate laser for laparoscopic removal of ovarian endometrioma.from january 1989 through january 1990, 31 patients thought to have ovarian endometrioma at ultrasonography were treated by operative laparoscopy and potassium-titanyl-phosphate laser. the endometriomas ranged from 2 to 9.2 cm in diameter by preoperative transvaginal ultrasonography. the operative procedure used was a three-puncture technique with a 600 micron fiber attached to a potassium-titanyl-phosphate laser. the power setting was 10 w with a continuous pulse. in all cases endometriomas wer ...20061828651
the use of potassium-titanyl-phosphate laser for laparoscopic removal of ovarian endometrioma.from january 1989 through january 1990, 31 patients thought to have ovarian endometrioma at ultrasonography were treated by operative laparoscopy and potassium-titanyl-phosphate laser. the endometriomas ranged from 2 to 9.2 cm in diameter by preoperative transvaginal ultrasonography. the operative procedure used was a three-puncture technique with a 600 micron fiber attached to a potassium-titanyl-phosphate laser. the power setting was 10 w with a continuous pulse. in all cases endometriomas wer ...20061828651
[spontaneous rupture of subclavian artery disclosing ehlers-danlos disease. a case].the authors report the case of a 30-year old man who suffered spontaneous rupture of the right subclavian artery. treatment consisted of carotid-axillary graft since the fragility of the vessel precluded direct suture. the clinical symptoms, together with histological and ultrastructural examinations led to a diagnosis of ehlers-danlos syndrome with purely arterial manifestations.19911828582
[value of periorbital ecchymosis in the diagnosis of amyloidosis]. 20071828572
laparoscopic cholecystectomy et al. 20061828530
laparoscopic cholecystectomy et al. 20061828530
tissue distribution of restricted leukocyte common antigens. a comprehensive study with protein- and carbohydrate-specific cd45r antibodies.a panel of monoclonal antibodies, specific for either protein or carbohydrate components of the leukocyte common antigen (lca), were used to characterize the expression pattern of different variants of this antigen complex. immunohistochemical and flow cytometric analysis was carried out on human lymphoid tissues from different anatomical compartments. we found that variations in terminal sialic acid or o-linked sugar moieties were associated with drastic differences in reactivity with some of t ...19911828514
tissue distribution of restricted leukocyte common antigens. a comprehensive study with protein- and carbohydrate-specific cd45r antibodies.a panel of monoclonal antibodies, specific for either protein or carbohydrate components of the leukocyte common antigen (lca), were used to characterize the expression pattern of different variants of this antigen complex. immunohistochemical and flow cytometric analysis was carried out on human lymphoid tissues from different anatomical compartments. we found that variations in terminal sialic acid or o-linked sugar moieties were associated with drastic differences in reactivity with some of t ...19911828514
allergic contact dermatitis due to benzoyl peroxide in an arm prosthesis. 20061828412
allergic contact dermatitis due to benzoyl peroxide in an arm prosthesis. 20061828412
[the cardiovascular system and antidepressive drugs].the authors consider the ever-increasing number of depressed patients, related to the stress of modern life and to the prolongation of life span. they stress that these patients are often cardiopathic or impaired by the senile heart. finally they illustrate the cardiovascular effects of antidepressant drugs and how to avoid them.20061828405
[the cardiovascular system and antidepressive drugs].the authors consider the ever-increasing number of depressed patients, related to the stress of modern life and to the prolongation of life span. they stress that these patients are often cardiopathic or impaired by the senile heart. finally they illustrate the cardiovascular effects of antidepressant drugs and how to avoid them.20061828405
the e2f transcription factor is a cellular target for the rb protein.although it is generally believed that the product of the retinoblastoma susceptibility gene (rb1) is an important regulator of cell proliferation, the biochemical mechanism for its action is unclear. we now show that the rb protein is found in a complex with the e2f transcription factor and that only the under phosphorylated form of rb is in the e2f complex. moreover, the adenovirus e1a protein can dissociate the e2f-rb complex, dependent on e1a sequence also critical for e1a to bind to rb. the ...20061828392
the e2f transcription factor is a cellular target for the rb protein.although it is generally believed that the product of the retinoblastoma susceptibility gene (rb1) is an important regulator of cell proliferation, the biochemical mechanism for its action is unclear. we now show that the rb protein is found in a complex with the e2f transcription factor and that only the under phosphorylated form of rb is in the e2f complex. moreover, the adenovirus e1a protein can dissociate the e2f-rb complex, dependent on e1a sequence also critical for e1a to bind to rb. the ...20061828392
socioeconomic status and morbidity and mortality in hypertensive blacks.despite an overall limited range of social and economic opportunities in the recent past, blacks of lower socioeconomic status have experienced marked excesses in hypertension-related burdens compared with their more advantaged peers: the incidence, prevalence, and severity of hypertension and its end-organ sequelae increased with decreasing educational achievement and the 5-year mortality was two times higher for black hypertensives of lower than higher educational achievement under conditions ...20061828391
socioeconomic status and morbidity and mortality in hypertensive blacks.despite an overall limited range of social and economic opportunities in the recent past, blacks of lower socioeconomic status have experienced marked excesses in hypertension-related burdens compared with their more advantaged peers: the incidence, prevalence, and severity of hypertension and its end-organ sequelae increased with decreasing educational achievement and the 5-year mortality was two times higher for black hypertensives of lower than higher educational achievement under conditions ...20061828391
inhibitory effect of inhaled procaterol on anaphylactic bronchoconstriction and thromboxane a2 production in guinea-pigs.this study was designed to examine whether an inhaled beta 2-agonist, procaterol, inhibits thromboxane a2 (txa2) production induced by antigen challenge in passively sensitized guinea-pigs in vivo. antigen-induced bronchoconstriction was markedly inhibited by pre-treatment with procaterol. inhaled procaterol significantly reduced in a dose-dependent manner the increment in txb2 concentration in bronchoalveolar lavage fluid obtained 5 min after antigen challenge. aerosol administration of procate ...19911828386
inhibitory effect of inhaled procaterol on anaphylactic bronchoconstriction and thromboxane a2 production in guinea-pigs.this study was designed to examine whether an inhaled beta 2-agonist, procaterol, inhibits thromboxane a2 (txa2) production induced by antigen challenge in passively sensitized guinea-pigs in vivo. antigen-induced bronchoconstriction was markedly inhibited by pre-treatment with procaterol. inhaled procaterol significantly reduced in a dose-dependent manner the increment in txb2 concentration in bronchoalveolar lavage fluid obtained 5 min after antigen challenge. aerosol administration of procate ...19911828386
vasomotion in venous disease.abnormalities of the capillary microcirculation may be important in the pathogenesis of venous ulceration. in this study the characteristics of capillary vasomotion in venous disease have been studied using laser doppler flowmetry. the amplitude and frequency of vasomotion in the skin microcirculation as measured by laser doppler flowmetry was determined in 101 subjects. these comprised 43 subjects with venous disease and lipodermatosclerosis (lds), 14 subjects with uncomplicated varicose veins ...20061828270
gtp-binding proteins transduce signals generated via human fc gamma receptor iiia (cd16).this study demonstrates that gtp-binding proteins regulate fc gamma riii-mediated signal transduction and inositol phosphate (ipn) generation in human nk cells. in addition the cross-linking of cd16 by mab, guanosine 5'-o-3-thiophosphate induced 1,4,5 inositol trisphosphate (ip3) release in permeabilized nk cells and their membranes. by contrast, guanosine 5'-o-2-thiophosphate, almost completely inhibited ip3 generation induced by cross-linking with anti-cd16 mab. pretreatment of nk cells with 1 ...19911827488
cost-benefit analysis of hepatitis b vaccination. 20071824729
familial predisposition for herniation of a lumbar disc in patients who are less than twenty-one years old.the parents of sixty-three patients who were less than twenty-one years old and who had operatively confirmed herniation of a lumbar disc were interviewed regarding a history of sever back pain, sciatica, and herniated disc, to determine whether aggregation of herniation of a lumbar disc occurs in families of patients in this young age-group. the parents of sixty-three additional patients who had a non-spinal orthopaedic diagnosis (control group) were matched for age and sex with the study group ...20071824705
cosmetic and clinical pictorial implant case presentations. 20071820803
cosmetic and clinical pictorial implant case presentations. 20071820803
[anti-inflammatory activities and effect of rhizoma alismatis on immune system].10 and 20 g/kg ig of rhizoma alismatis (ra) markedly decrease the clearance rate of charcoal particles in mice, but have no significant effect on the weight of immune organs, or on the content of serum antibody hemolysin and immunoglobulin g and the delayed footpad edema induced by sheep red blood cell. the contact dermatitis of mouse pinnae immunized with dinitrochlorobenzene is inhibited by ra when it is given before challenge. in addition, ra 20g/kg suppresses the swelling of mouse rinnae ind ...19911820797
[anti-inflammatory activities and effect of rhizoma alismatis on immune system].10 and 20 g/kg ig of rhizoma alismatis (ra) markedly decrease the clearance rate of charcoal particles in mice, but have no significant effect on the weight of immune organs, or on the content of serum antibody hemolysin and immunoglobulin g and the delayed footpad edema induced by sheep red blood cell. the contact dermatitis of mouse pinnae immunized with dinitrochlorobenzene is inhibited by ra when it is given before challenge. in addition, ra 20g/kg suppresses the swelling of mouse rinnae ind ...19911820797
myeloid leukemoid reaction in malaria infection. 20071820659
[sepsis due to vibrio cholerae no 01].two fatal sepsis cases in two male patients (58 and 14 years old) due to vibrio cholerae non 01 are described. their original diseases were hepatic cirrhosis and acute lymphoblastic leukemia in its third complete remission. in this last case, gastroenteritis due to v. cholerae non 01 was also diagnosed. these sepsis presented a rapid evolution and positive hemoculture after 24 and 48 hours of incubation. both strains isolated presented similar biochemical characteristics and did not agglutinate ...19911820501
global climate change and infectious diseases.the effects of global climate change on infectious diseases are hypothetical until more is known about the degree of change in temperature and humidity that will occur. diseases most likely to increase in their distribution and severity have three-factor (agent, vector, and human being) and four-factor (plus vertebrate reservoir host) ecology. aedes aegypti and aedes albopictus mosquitoes may move northward and have more rapid metamorphosis with global warming. these mosquitoes transmit dengue v ...19911820262
[central serous retinopathy (atypical forms)].in comparison with the typical forms of the central serous chorioretinopathy (cscr), atypical forms are characterized by an older age, the presence of multiple and bilateral foci, the higher tendency for recurrence and the more accentuated functional damages. they may take the form of drpe (diffuse retinal pigment epitheliopathy) and of gravitational epitheliopathy. sedative therapy is justified by the particular psychic background which often accompanies this disease. photocoagulation must be p ...20061817714
[central serous retinopathy (atypical forms)].in comparison with the typical forms of the central serous chorioretinopathy (cscr), atypical forms are characterized by an older age, the presence of multiple and bilateral foci, the higher tendency for recurrence and the more accentuated functional damages. they may take the form of drpe (diffuse retinal pigment epitheliopathy) and of gravitational epitheliopathy. sedative therapy is justified by the particular psychic background which often accompanies this disease. photocoagulation must be p ...20061817714
domiciliary oxygen concentrators in anaesthesia. 20071817638
[a study on diarrhoea disease caused by vibrionaceae along coast the east of zhejiang province].a study of the etiology of 1028 cases of acute diarrhoea due to vibrionaceae was carried out between august 1988 to july 1990 along the coast of east zhejiang province. from 417 clinical cases (40.56%) were found. 590 strains (57.39%) of pathogenic vibrios among them, the detection rates of vibrio, aeromonas and plesionmonas were 48.14%, 44.74%, 7.12% respectively. there were 8 species of vibrio detected: v. parahemolyticus (63.73%), v. fluvialis (11.97%), v. alginolyticus (10.215), non-01 vibri ...19911816992
[identification of species of microorganisms of the genus vibrio].during 1988, a study was made on 61 microorganisms, genus vibrio, which were received at the national reference laboratory for acute diarrheic diseases. pedro kouri institute of tropical medicine. of them, 46 were from children with acute diarrheic disease and 15 were isolated from the environment. by means of biochemical tests. 61 vibrio cholerae no. 01. 9 vibrio parahaemolyticus and 1 vibrio alginolyticus were identified. emphasis is placed upon the importance of keeping a systematic surveilla ...19911812527
comparison of glucose/electrolyte and maltodextrin/glycine/glycyl-glycine/electrolyte oral rehydration solutions in cholera and watery diarrhoea in adults.one hundred and eight male adults (mean age 33 +/- 1.7 years) presenting with watery diarrhoea of less than 48 hours duration at home prior to hospitalization and with clinically evident (grade ii, severe) dehydration were admitted into a randomized double-blind clinical trial; 54 were treated with standard oral rehydration solution (ors)--who formulation containing citrate--and 54 with an improved ors formulation which contained, in addition to the standard formula, maltodextrin 20 g (instead o ...19911811441
[the origin of el tor cholera]. 19911811396
[dynamic changes in the biological properties of vibrio cholerae during long-term preservation in water and ice]. 19911811381
[the lipids of phosphorescent vibrio albensis bacteria].the lipid composition of fluorescent vibrios, v. eltor and nonagglutinating vibrios has been studied. in the fraction of polar lipids phosphatidylethanolamine, phosphatidylinositol and cardiolipin and in the fraction of neutral lipids monoglycerides, free fatty acids, diglycerides, triglycerides, sterol esters have been identified. the fatty acid composition of some classes of neutral lipids have been determined. both similarity and differences between the strains under study in their lipid and ...19911811379
genetic markers in the blood of multiple sclerosis patients.poligenetically determined predisposition to multiple sclerosis (ms) defines the way of immunological reaction to environmental factors and leads to clinically manifest disease. although the connection between ms and some loci of the hla system has been established, the hereditary predisposition to ms remains to be elucidated. we determined the phenotypes of monogenic hereditary characteristics linked to the surface of red blood cells that were obtained from 45 ms patients and 458 healthy subjec ...20071810395
[the anatomical and functional origin of the first bipedalism].this communication is the synthesis of ten years of researchers of comparative anatomy done by the author or under his control on fossil hominids, three million years old, found by his expeditions in eastern ethiopia. it brings, for the first time, the odd picture of a skeleton adapted to arboricolism and bipedalism together. the rachis has already the curves of an erect being but with at least a thoraco-lumbar cyphosis a bit more elongated than in our own rachis; the pelvis is wide and shallow ...19911809491
serum and breast milk antibodies to food antigens in african mothers and relation to their diet.results of a series of historical and recent studies of human milk and its protective antibodies against several bacterial and viral diseases and infantile diarrhea are presented. first, 1476 infants from lahore, pakistan from 3 socioeconomic groups, were observed and 300 mothers were given instruction on exclusive breast feeding. the prevalence of diarrhea indicated 60-80% protection to consistency of breast feeding, especially in summer when mothers replace breast milk with other liquids. h ...19911808999
identification and use of protective monoclonal iga antibodies against viral and bacterial pathogens. 19911808995
an aberrant hemolysin of vibrio cholerae non-o1.an aberrant hemolysin produced by a vibrio cholerae non-o1 strain n037 (n037-hly) was purified and characterized. n037-hly was antigenically very similar to el tor hemolysin but differed in molecular weight (48,000 vs. 60,000), interaction with glucose, and hemolytic activity. of 100 v. cholerae non-o1 strains other than the n037 strain examined, none produced this aberrant hemolysin. the n-terminal amino acid sequence of n037-hly was highly homologous to that of el tor hemolysin.19911808468
[education the health sciences in cuba]. 20071807950
acute intoxication as a cause of wild bird mortality in the netherlands from 1975-1989. 20071805755
'occupational hazards to dental staff'. 20071804266
[the protective effects of paeonol on cultured neonatal rat heart cells during calcium paradox].it has been found that the rapid (5min) and slow (120min) phases of 15ca uptake by normal myocardial cells and their beating rate are remarkably inhibited by paeonol. and that paeonol can also decrease 45ca uptake and lipid peroxide in calcium paradoxical heart cells, which appears in dose-dependence. this indicates that the mechanism of protection of paconol against calcium paradox is associated with its inhibition of ca2+ influx and antioxidation.19911804206
environmental health conditions and cholera vulnerability in latin america and the caribbean.epidemic cholera reached south america in january 1991 and later spread to central america and the united states. it afflicted 312,000 people and claimed 3200 lives. since cholera had not been in latin america for almost 70 years, health authorities allowed environmental health barriers to cholera collapse. for example, the governments of the region agreed in 1961 to abide by the charter of punta del este to provide water and sewerage to 70% of the urban population and 50% f the rural populat ...19911802889
pharmacological properties of cloned muscarinic receptors expressed in a9 l cells; comparison with in vitro models.the effects of a series of muscarinic agonists and antagonists at cloned m1 and m3 muscarinic receptors expressed in mouse fibroblast a9 l cells have been compared with their effects in in vitro models of m1 (rat superior cervical ganglion) and m3 (guinea-pig ileum) muscarinic receptors. a good correlation existed between the potencies of muscarinic agonists at cloned m1 muscarinic receptors and the m1 sites in rat ganglion (r = 0.80) as well as at cloned m3 receptors and guinea-pig ileum m3 rec ...19911802743
detection of a heat-labile enterotoxin gene in enterotoxigenic escherichia coli by densitometric evaluation using highly specific enzyme-linked oligonucleotide probes.two alkaline phosphatase-conjugated 24-mer oligonucleotide probes were developed to detect the heat-labile enterotoxin gene in enterotoxigenic escherichia coli. probes were antisense codon sequences, which are transcribed into mrna, of the heat-labile enterotoxin gene of enterotoxigenic escherichia coli of human origin. using dot-blot hybridization, probes were tested with 100 clinical isolates and evaluated by a reflectance-type densitometer. results agreed very well with those of an immunologi ...19911802695
[an experimental study on the treatment of asthmatics with diethylcarbamazine].this study was designed to assess the effectiveness of oral administration of diethylcarbamazine (dec) on the treatment of asthmatics. when compared to baseline and placebo control dec failed to improve significantly lung ventilation function within 3 hours in 28 asthmatics. in 11 patients with stable asthma a significant increase in mch-pc20-fev1 was noticed at 3 days after the use of dec. in 24 atopic asthmatics dec given 90 minutes prior to exercise led to significantly less post-exercise per ...20051802434
coincident recording and stimulation of single and multiple neuronal activity with one extracellular microelectrode.this paper describes how an extracellular microelectrode may be used to stimulate neurons with brief, rectangular pulses and afterwards directly record the resultant activity. two obstacles are the stimulus artifact lingering in the electrical circuitry and transient tip potentials (ttps) arising from ion depletion at the electrode-tissue interface. electronic switching between the stimulus source and the recording amplifier eliminates direct stimulus artifact from the electrical circuitry, alth ...19911800855
[a case of idiopathic aseptic osteonecrosis of the patellae: repeat study of tc-99m hmdp bone scintigraphy in a reparative phase].a 37-year-old woman entered our hospital because of bilateral knee pain. tc-99m hmdp bone scintigram demonstrated increased activity in the bilateral patellae and cold lesion in the center and left lateral segments of the left patellae, so-called doughnut pattern. trephine biopsy was performed to prove bilateral idiopathic asepct osteonecrosis of the patellae. the knee pain subsided and a bone scan 5 months later demonstrated increased activity in the bilateral patellae more widely than initial ...20061800777
[a case of idiopathic aseptic osteonecrosis of the patellae: repeat study of tc-99m hmdp bone scintigraphy in a reparative phase].a 37-year-old woman entered our hospital because of bilateral knee pain. tc-99m hmdp bone scintigram demonstrated increased activity in the bilateral patellae and cold lesion in the center and left lateral segments of the left patellae, so-called doughnut pattern. trephine biopsy was performed to prove bilateral idiopathic asepct osteonecrosis of the patellae. the knee pain subsided and a bone scan 5 months later demonstrated increased activity in the bilateral patellae more widely than initial ...20061800777
the accuracy of confrontation visual field test in comparison with automated perimetry.the accuracy of confrontation visual field testing was determined for 512 visual fields using automated static perimetry as the reference standard. the sensitivity of confrontation testing excluding patchy defects was 40% for detecting anterior visual field defects, 68.3% for posterior defects, and 50% for both anterior and posterior visual field defects combined. the sensitivity within each group varied depending on the type of visual field defect encountered. confrontation testing had a high s ...20061800764
the accuracy of confrontation visual field test in comparison with automated perimetry.the accuracy of confrontation visual field testing was determined for 512 visual fields using automated static perimetry as the reference standard. the sensitivity of confrontation testing excluding patchy defects was 40% for detecting anterior visual field defects, 68.3% for posterior defects, and 50% for both anterior and posterior visual field defects combined. the sensitivity within each group varied depending on the type of visual field defect encountered. confrontation testing had a high s ...20061800764
a general software package for the handling of medical images.pics (portable imaging computer software), is a software system designed for handling and processing a variety of types of medical image. it has been designed to satisfy the following criteria: (a) the software should be portable between different items of hardware with minimal alteration; (b) there should be a simple operator interface to enable use by inexperienced users, while avoiding the need for experienced users to be directed through tedious menu trees; (c) the programming environment sh ...20061800747
a general software package for the handling of medical images.pics (portable imaging computer software), is a software system designed for handling and processing a variety of types of medical image. it has been designed to satisfy the following criteria: (a) the software should be portable between different items of hardware with minimal alteration; (b) there should be a simple operator interface to enable use by inexperienced users, while avoiding the need for experienced users to be directed through tedious menu trees; (c) the programming environment sh ...20061800747
tooth contact patterns in patients with temporomandibular dysfunction.the occlusal tooth contact patterns in patients with temporomandibular dysfunction and normal subjects were studied under a range of conditions using a newly devised radiotelemetry system. the patterns in the patient group were completely different from those in the control group. during rest or work, the patients showed higher values for total number and time of tooth contacts, as well as several contacts of extended duration. moreover, many of the tooth contacts during swallowing were plural c ...20061800694
tooth contact patterns in patients with temporomandibular dysfunction.the occlusal tooth contact patterns in patients with temporomandibular dysfunction and normal subjects were studied under a range of conditions using a newly devised radiotelemetry system. the patterns in the patient group were completely different from those in the control group. during rest or work, the patients showed higher values for total number and time of tooth contacts, as well as several contacts of extended duration. moreover, many of the tooth contacts during swallowing were plural c ...20061800694
hypopituitarism following snake bite.a patient who developed hypopituitarism after viperine envenomation is described. thrombosis as a part of disseminated intravascular coagulation may have been the cause. hypopituitarism should be suspected in such cases especially when there is associated acute renal failure.20071800512
prognostic indicators and risk factors for increased duration of acute diarrhoea and for persistent diarrhoea in children.to identify the prognostic indicators and risk factors for increased duration of acute diarrhoea and for occurrence of persistent diarrhoea (i.e. acute episodes lasting longer than 14 days) in children under three years, a systematic sample (3690) of patients attending a large treatment centre in bangladesh was analysed using multiple regression, logistic regression and stratified (mantel-haenszel) analysis. significant prognostic indicators or risk factors for increase in duration of acute diar ...19911800405
role of faecal leucocytes in the diagnostic evaluation of acute diarrhoea.the value of faecal leucocyte examination was assessed in 400 infants with acute diarrhoea and 40 normal healthy infants. enteropathogens were isolated from 28.75%. escherichia coli was the commonest (16.5%) followed by salmonella typhimurium (7%), vibrio cholerae (3.25%) and shigella flexneri (1.5%). exudative response was observed in 57.1% of stools with salmonella and 66.6% each with shigella and e.i.e.c. infections. 81.3%, 89.5% and 87.7% of stools from which epec and etec and no enteropatho ...19911797652
inbreeding in saguenay-lac-st-jean (quebec, canada): a study of catholic church dispensations 1842-1971.saguenay-lac-st-jean (slsj) is a rather geographically isolated region of quebec which shows a high occurrence of hereditary disorders. it has been suggested that high inbreeding might explain this situation. we studied the inbreeding in the slsj region by 10-year periods from 1842 till 1971 using the catholic church dispensations. the values of the mean inbreeding coefficient were found to be low during the whole period, reaching a peak of 22.94 x 10(-4) during the period 1902-1911. the values ...20071797631
plant resistance mechanisms to air pollutants: rhythms in ascorbic acid production during growth under ozone stress.relationships between ozone (o3) tolerance and leaf ascorbic acid concentrations in o3-susceptible (o3-s) 'hark' and o3-resistant (o3-r) 'hood' soybean, glycine max (l.) merr., cultivars were examined with high-performance liquid chromatography (hplc). leaf samples were analyzed at 4 intervals during a 24 h period. soybean cultivars grown in the greenhouse with charcoal filtered (cf) and nonfiltered (nf) air showed daily oscillations in ascorbic acid production. highest ascorbic acid levels in l ...20061797413
plant resistance mechanisms to air pollutants: rhythms in ascorbic acid production during growth under ozone stress.relationships between ozone (o3) tolerance and leaf ascorbic acid concentrations in o3-susceptible (o3-s) 'hark' and o3-resistant (o3-r) 'hood' soybean, glycine max (l.) merr., cultivars were examined with high-performance liquid chromatography (hplc). leaf samples were analyzed at 4 intervals during a 24 h period. soybean cultivars grown in the greenhouse with charcoal filtered (cf) and nonfiltered (nf) air showed daily oscillations in ascorbic acid production. highest ascorbic acid levels in l ...20061797413
persistence of cell division synchrony in spirogyra insignis (gamophyceae): membrane proteoglycans transmitting synchronizing information throughout generations.spirogyra insignis shows a long-term persistence of cell division synchrony in the absence of the synchronizing zeitgeber, so that at least six generations are involved in the process. this tentatively suggests that a mechanism of transmission throughout generations of synchronizing information could maintain this synchrony. apparently, a vital part of the molecular basis of this mechanism is a membrane proteoglycan complex. this complex could obtain temporal information from a synchronizing zei ...20061797412
persistence of cell division synchrony in spirogyra insignis (gamophyceae): membrane proteoglycans transmitting synchronizing information throughout generations.spirogyra insignis shows a long-term persistence of cell division synchrony in the absence of the synchronizing zeitgeber, so that at least six generations are involved in the process. this tentatively suggests that a mechanism of transmission throughout generations of synchronizing information could maintain this synchrony. apparently, a vital part of the molecular basis of this mechanism is a membrane proteoglycan complex. this complex could obtain temporal information from a synchronizing zei ...20061797412
proton and carbon chemical-shift assignments for 6-kestose and neokestose from two-dimensional n.m.r. measurements.the proton and carbon chemical shift assignments of the simplest levan, 6-kestose, [o-beta-d-fructofuranosyl-(2----6)-beta-d-fructofuranosyl-(2 in equilibrium with 1)-alpha-d-glucopyranoside], along with another trisaccharide, neokestose, [o-beta-d-fructofuranosyl-(2----6)-alpha-d-glucopyranosyl-(1 in equilibrium with 2)-beta-d-fructofuranoside], were determined using two-dimensional (2d) homonuclear and heteronuclear n.m.r. methods. the 1h peak of h-1 of the glucose residue was determined by it ...20061797405
proton and carbon chemical-shift assignments for 6-kestose and neokestose from two-dimensional n.m.r. measurements.the proton and carbon chemical shift assignments of the simplest levan, 6-kestose, [o-beta-d-fructofuranosyl-(2----6)-beta-d-fructofuranosyl-(2 in equilibrium with 1)-alpha-d-glucopyranoside], along with another trisaccharide, neokestose, [o-beta-d-fructofuranosyl-(2----6)-alpha-d-glucopyranosyl-(1 in equilibrium with 2)-beta-d-fructofuranoside], were determined using two-dimensional (2d) homonuclear and heteronuclear n.m.r. methods. the 1h peak of h-1 of the glucose residue was determined by it ...20061797405
2,3-didehydro-2-deoxysialic acids structurally varied at c-5 and their behaviour towards the sialidase from vibrio cholerae.2,3-didehydro-2-deoxy-n-trifluoroacetylneuraminic acid (5-trifluoroacetyl-neu2en) (3) has been synthesised from neu5ac2en (1) by hydrazinolysis, to give neu2en (2), followed by n-trifluoroacetylation. 2,3-didehydro-2,3-dideoxy-d-glycero-d-galacto-2-nonulopyranoson ic acid (kdn2en, 8) and 5-azido-2,3-didehydro-2,3,5-trideoxy-d-glycero-d-galacto-2-nonu lopyranosonic acid (5-azido-5-deoxy-kdn2en, 9) have been prepared from the acetylated methyl esters of kdn (4) and 5-azido-5-deoxy-kdn (5) via zemp ...19911797392
[photic maculopathy by low energy laser beam. a case report].the authors report a case of photic maculopathy that developed in a 30-year-old laboratory worker after repeated, consecutive exposure to low energy he-ne laser. pigmented foveal change and a small central scotoma in the right eye with window defect on fluorescein angiography characterized this maculopathy. photochemical damage is considered to be the cause of the maculopathy.20061797372
[photic maculopathy by low energy laser beam. a case report].the authors report a case of photic maculopathy that developed in a 30-year-old laboratory worker after repeated, consecutive exposure to low energy he-ne laser. pigmented foveal change and a small central scotoma in the right eye with window defect on fluorescein angiography characterized this maculopathy. photochemical damage is considered to be the cause of the maculopathy.20061797372
androgen effects on the development of the zebra finch song system.in adult zebra finches, males sing and females do not. this behavioral sex difference is associated with sex differences in brain regions that control singing. treatment of hatchling females with androgen causes permanent masculinization of neuron number in the robust nucleus of the archistriatum (ra), a brain region involved in song. we have re-examined the possible permanent effects of androgen on the zebra finch song system by treating male and female hatchlings with silastic implants contain ...20061797353
androgen effects on the development of the zebra finch song system.in adult zebra finches, males sing and females do not. this behavioral sex difference is associated with sex differences in brain regions that control singing. treatment of hatchling females with androgen causes permanent masculinization of neuron number in the robust nucleus of the archistriatum (ra), a brain region involved in song. we have re-examined the possible permanent effects of androgen on the zebra finch song system by treating male and female hatchlings with silastic implants contain ...20061797353
a calcitonin gene-related peptide (cgrp) antagonist (cgrp8-37) inhibits microvascular responses induced by cgrp and capsaicin in skin.1. the effect of the calcitonin gene-related peptide (cgrp) antagonist cgrp8-37 on responses to cgrp and other mediators was investigated in rabbit dorsal skin. 2. blood flow changes at intradermally-injected sites were measured by a multiple site 133xenon clearance technique. cgrp8-37 had little effect on blood flow at doses up to 0.3 nmol/site, when injected alone, although a significant increase in blood flow was observed at the highest dose tested (1 nmol/site). 3. cgrp8-37 dose-dependently ...19911797334
a calcitonin gene-related peptide (cgrp) antagonist (cgrp8-37) inhibits microvascular responses induced by cgrp and capsaicin in skin.1. the effect of the calcitonin gene-related peptide (cgrp) antagonist cgrp8-37 on responses to cgrp and other mediators was investigated in rabbit dorsal skin. 2. blood flow changes at intradermally-injected sites were measured by a multiple site 133xenon clearance technique. cgrp8-37 had little effect on blood flow at doses up to 0.3 nmol/site, when injected alone, although a significant increase in blood flow was observed at the highest dose tested (1 nmol/site). 3. cgrp8-37 dose-dependently ...19911797334
comparison of the electrophysiological effects of org 7797, disopyramide, mexiletine and propafenone in anaesthetized dogs with myocardial infarcts.1. the electrophysiological effects of intravenously administered org 7797 were compared with those of disopyramide (class ia), mexiletine (ib) and propafenone (ic) in anaesthetized dogs with 5-6 day-old left ventricular myocardial infarcts. 2. org 7797 (0.5 mg kg-1) slowed conduction at all levels of the myocardium as shown by increases in st-a, ah, hv and qrs intervals, very modestly prolonged atrial and ventricular refractory periods and slightly shortened ventricular repolarization. sinus no ...19911797309
comparison of the electrophysiological effects of org 7797, disopyramide, mexiletine and propafenone in anaesthetized dogs with myocardial infarcts.1. the electrophysiological effects of intravenously administered org 7797 were compared with those of disopyramide (class ia), mexiletine (ib) and propafenone (ic) in anaesthetized dogs with 5-6 day-old left ventricular myocardial infarcts. 2. org 7797 (0.5 mg kg-1) slowed conduction at all levels of the myocardium as shown by increases in st-a, ah, hv and qrs intervals, very modestly prolonged atrial and ventricular refractory periods and slightly shortened ventricular repolarization. sinus no ...19911797309
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