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subject-based feature extraction by using fisher wpd-csp in brain-computer interfaces.feature extraction of electroencephalogram (eeg) plays a vital role in brain-computer interfaces (bcis). in recent years, common spatial pattern (csp) has been proven to be an effective feature extraction method. however, the traditional csp has disadvantages of requiring a lot of input channels and the lack of frequency information. in order to remedy the defects of csp, wavelet packet decomposition (wpd) and csp are combined to extract effective features. but wpd-csp method considers less abou ...201627084317
recurrent guillain-barré syndrome, miller fisher syndrome and bickerstaff brainstem encephalitis.guillain-barré syndrome (gbs), miller fisher syndrome (mfs), and bickerstaff brainstem encephalitis (bbe) are usually monophasic, but some patients experience recurrences after long asymptomatic intervals. we aimed to investigate clinical features of recurrent gbs, mfs, and bbe at a single hospital.201627084218
factors impacting press ganey patient satisfaction scores in orthopedic surgery spine clinic.patient satisfaction is and will continue to become an important metric in the american health care system. to our knowledge, there is no current literature exploring the factors that impact patient satisfaction in outpatient orthopedic spine surgery clinic.201627084192
optimization of the pediatric head computed tomography scan image quality: reducing dose with an automatic tube potential selection in infants.the objective of our study was to evaluate the impact of an automatic tube potential selection (atps) on the delivered dose and image quality in unenhanced head computed tomography (ct) scans of infants.201627083689
comparison of removable and irremovable walking boot to total contact casting in offloading the neuropathic diabetic foot ulceration.despite its efficacy in healing neuropathic diabetic foot ulcers (dfus), total contact cast (tcc) is often underused because of technical limitations and poor patient acceptance. we compared tcc to irremovable and removable commercially available walking boots for dfu offloading.201627083507
sentinel lymph node biopsy can be omitted in dcis patients treated with breast conserving therapy.breast cancer guidelines advise sentinel lymph node biopsy (slnb) in patients with ductal carcinoma in situ (dcis) on core biopsy at high risk of invasive cancer or in case of mastectomy. this study investigates the incidence of slnb and sln metastases and the relevance of indications in guidelines and literature to perform slnb in order to validate whether slnb is justified in patients with dcis on core biopsy in current era. clinically node negative patients diagnosed from 2004 to 2013 with on ...201627083179
quantum electrodynamics in d=3 from the ε expansion.we study quantum electrodynamics in d=3 coupled to n_{f} flavors of fermions. the theory flows to an ir fixed point for n_{f} larger than some critical number n_{f}^{c}. for n_{f}≤n_{f}^{c}, chiral-symmetry breaking is believed to take place. in analogy with the wilson-fisher description of the critical o(n) models in d=3, we make use of the existence of a fixed point in d=4-2ε to study the three-dimensional conformal theory. we compute, in perturbation theory, the ir dimensions of fermion bilin ...201627081967
clinical diagnosis and chemical confirmation of ciguatera fish poisoning in new south wales, australia.ciguatera fish poisoning is common in tropical and sub-tropical areas and larger fish (> 10 kg) are more susceptible to toxin accumulation with age. although the coastal climate of northern new south wales is considered sub-tropical, prior to 2014 there has only been 1 documented outbreak of ciguatera fish poisoning from fish caught in the region. during february and march 2014, 2 outbreaks of ciguatera fish poisoning involved 4 and 9 individuals, respectively, both following consumption of span ...201627080020
small intrahepatic cholangiocarcinoma and hepatocellular carcinoma in cirrhotic livers may share similar enhancement patterns at multiphase dynamic mr imaging.purpose to assess the accuracy of magnetic resonance (mr) imaging-based differential diagnosis of hepatocellular carcinoma (hcc) and intrahepatic cholangiocarcinoma (icc) in a cohort of patients with focal liver lesions and cirrhosis. materials and methods this study was institutional review board approved, and the requirement for informed consent was waived. between january 2009 and december 2014, a cohort of cirrhotic patients, including 71 with icc and 612 with hcc, underwent unenhanced t1- a ...201627077381
the effect of washing water temperature on resin-dentin micro-shear bond strength.the purpose of this study was to evaluate the effect of washing water temperature on the micro-shear bond strength (μsbs) of composite resin to dentin using a two-step etch-and-rinse system and a two-step self-etching system.201727076833
sensitization profiles to peanut allergens in belgium; cracking the code in infants, children and adults.peanut allergy shows distinct clinical patterns that can be predicted by component resolved diagnosis. however, data about peanut sensitization profiles in populations with a broad age stratification are scarce.201627075794
periodontal pathogenic bacteria and ammp-8 findings depending on periodontal conditions of patients before and after liver transplantation.the aim of this single-center cross-sectional study was to detect the prevalence of selected periodontal pathogenic bacteria and active matrix metalloproteinase-8 (ammp-8) level in patients before (preltx) and after liver transplantation (postltx).201727074844
assessment of interobserver agreement and use of selected magnetic resonance imaging variables for differentiation of acute noncompressive nucleus pulposus extrusion and ischemic myelopathy in dogs.objective to evaluate interobserver agreement for features used in presumptive diagnosis of acute noncompressive nucleus pulposus extrusion (annpe) or ischemic myelopathy by mri, compare findings on postcontrast t1-weighted (t1w) mri sequences with fat saturation (fs) for the 2 conditions, and determine whether length and directional patterns of hyperintensity of the intramedullary spinal cord on t2-weighted (t2w) fast spin echo (fse) mri sequences differ between dogs with these diseases. design ...201627074609
acute ataxia in childhood: 11-year experience at a major pediatric neurology referral center.we categorized the causes of acute ataxia in the pediatric population-referred to the division of neurology-at a large, urban pediatric medical center. of the 120 cases identified over the past 11 years, post-infectious cerebellar ataxia was the most commonly diagnosed (59%), followed by drug intoxication, opsoclonus-myoclonus ataxia syndrome, episodic ataxia, acute cerebellitis, cerebellar stroke, adem, meningitis, cerebral vein thrombosis, leigh's disease, miller-fisher syndrome, and concussio ...201627071467
self-reported oral health behaviour among scandinavian and polish medical students studying in poland.the aim of the study was to assess the self-reported oral health behaviour of scandinavian and polish medical students studying in poland.201627070972
predictors of aneurysmal rebleed before definitive surgical or endovascular management.aneurysmal rebleed is the most dreaded complication following subarachnoid hemorrhage. being a cause of devastating outcome, the stratification of risk factors can be used to prioritize patients, especially at high volume centers.201627068042
in silico prioritization based on coexpression can aid epileptic encephalopathy gene discovery.to evaluate the performance of an in silico prioritization approach that was applied to 179 epileptic encephalopathy candidate genes in 2013 and to expand the application of this approach to the whole genome based on expression data from the allen human brain atlas.201627066588
overlap between parkinson disease and alzheimer disease in abca7 functional variants.given their reported function in phagocytosis and clearance of protein aggregates in alzheimer disease (ad), we hypothesized that variants in atp-binding cassette transporter a7 (abca7) might be involved in parkinson disease (pd).201627066581
permissible noninformative priors for the accelerated life test model with censored data.in this paper, the jeffreys priors for the step-stress partially accelerated life test with type-ii adaptive progressive hybrid censoring scheme data are considered. given a density function family satisfied certain regularity conditions, the fisher information matrix and jeffreys priors are obtained. taking the weibull distribution as an example, the jeffreys priors, posterior analysis and its permissibility are discussed. the results, which present that how the accelerated stress levels, censo ...201627065208
risk factors associated with pediatric acute recurrent and chronic pancreatitis: lessons from insppire.pediatric acute recurrent pancreatitis (arp) and chronic pancreatitis (cp) are poorly understood.201627064572
the characteristics of women who use hypnotherapy for intrapartum pain management: preliminary insights from a nationally-representative sample of australian women.this manuscript presents a preliminary examination of the characteristics of women who choose intrapartum hypnosis for pain management.201627062951
mutation detection rates associated with specific selection criteria for brca1/2 testing in 1854 high-risk families: a monocentric italian study.brca mutation screening is frequently offered on the basis of the fulfillment of empirical selection criteria, thought to be indicative of a genetic predisposition to breast/ovarian cancer (brca/ovca). this study aimed to evaluate, in a large cohort of brca/ovca families, the mutation detection rate (dr) associated with specific clinical features and the relative performance of the employed selection criteria.201627062684
impact of system-wide king lt airway implementation on orotracheal intubation.orotracheal intubation is a key component of prehospital airway management and success rates are dependent on procedural experience. supraglottic airway devices are increasingly being used in the prehospital setting. as a result, paramedics may have fewer opportunities for performing intubation, limiting their proficiency in the procedure. we aimed to determine the trends in intubation versus supraglottic airway use over an 8 year period. we also aimed to determine the association between system ...201627058646
biological effects of a root conditioning treatment on periodontally affected teeth--an in vitro analysis.the aim of this study was to evaluated the root surfaces modifications resulted by application of different chemicals agents, and their influence on the fibrin network and fibroblasts attachment. from 96 anterior mandibular human extracted incisor teeth, 192 dentin blocks of buccal and lingual surface were obtained and randomly divided into 6 groups: cont- control group, which received no treatment; root surface scaling and root planing (srp); citric acid-srp; edta-srp; tetracycline capsule-srp; ...201727058378
chagas' disease in aboriginal and creole communities from the gran chaco region of argentina: seroprevalence and molecular parasitological characterization.most indigenous ethnias from northern argentina live in rural areas of "the gran chaco" region, where trypanosoma cruzi is endemic. serological and parasitological features have been poorly characterized in aboriginal populations and scarce information exist regarding relevant t. cruzi discrete typing units (dtu) and parasitic loads. this study was focused to characterize t. cruzi infection in qom, mocoit, pit'laxá and wichi ethnias (n=604) and creole communities (n=257) inhabiting rural village ...201627057620
asian patients with dyslipidemia in an urban population: effect of ethnicity on their ldl-cholesterol treatment goals.dyslipidemia is the primary risk factor for arthrosclerosis. it is the most common chronic disease among the multiethnic asian population in singapore. local national health survey has shown ethnic variability in achieving control of dyslipidemia.201627055972
evaluation and comparison of transverse and impact strength of different high strength denture base resins.the present study was undertaken to evaluate and compare the impact strength and transverse strength of the high-impact denture base materials. a conventional heat polymerized acrylic resin was used as a control.201727054863
postendarterectomy cerebral hyperperfusion syndrome: the etiological significance of "cerebral reserve".postoperative cerebral hyperperfusion syndrome (chs) in patients undergoing carotid intervention is thought to be related to the absence of cerebral reserve. although hyperperfusion syndrome is rare, severe postoperative headache is common and is considered to be a prodromal sign. cerebral reserve is measured by studying the response of cerebral vessels to a vasodilator such as hypercarbia. we produced hypercarbia by holding respiration for 60 seconds during carotid endarterectomy. we attempted ...201427053914
epidemiological study of bovine brucellosis in three senatorial zones of bauchi state, nigeria.to determine the seroepidemiological patterns of bovine brucellosis in three senatorial zones of bauchi state, nigeria.201627051184
comprehensive analysis of the clinical and urodynamic outcomes of primary tethered spinal cord before and after spinal cord untethering.primary tethered spinal cord (tsc) refers to a group of abnormalities associated with a posterior bony spinal defect that develops beneath an intact dermis and epidermis. there is relative agreement that patients with symptomatic tsc will require surgical intervention. however, it is still debatable as to how to approach asymptomatic patients with primary tsc.201627049673
compact representation of high-dimensional feature vectors for large-scale image recognition and retrieval.in large-scale visual recognition and image retrieval tasks, feature vectors, such as fisher vector (fv) or the vector of locally aggregated descriptors (vlad), have achieved state-of-the-art results. however, the combination of the large numbers of examples and high-dimensional vectors necessitates dimensionality reduction, in order to reduce its storage and cpu costs to a reasonable range. in spite of the popularity of various feature compression methods, this paper shows that the feature (dim ...201627046897
comparing unmet needs to optimize quality: characterizing inpatient and outpatient palliative care populations.palliative care (pc) consultation services are available in most hospitals; outpatient services are rapidly growing to meet the needs of patients at earlier stages of the disease trajectory.201627046299
hypochloraemia as a predictor of developing hyponatraemia and poor outcome in acute heart failure patients.heart failure (hf) is a major public health issue currently affecting more than 23 million patients worldwide. hyponatraemia has been shown to be a predictor of poor outcome in patients with acute and chronic hf. therefore, we aimed at finding a marker for early detection of patients at risk for developing hyponatraemia. to this end, the present study investigated the relationship between initial serum chloride and follow-up sodium levels in acute heart failure (ahf) patients.201627045878
hepatitis b birth dose vaccination rates among children in beijing: a comparison of local residents and first and second generation migrants.providing hepatitis b vaccine to all neonates within 24 hours of birth (timely birth dose, tbd) is the key preventative measure to control perinatal hepatitis b virus infection. previous chinese studies of tbd only differentiated between migrant and non-migrant (local-born generation-lg) children. our study is the first to stratify migrants in beijing into first generation migrants (fgm) and second generation migrants (sgm). based on a questionnaire survey of 2682 people in 3 beijing villages, w ...201627043864
survey of provider transfusion practices for oncology patients in an academic medical center.hospitalized oncology patients receive care from a variety of professionals, each of whom plays a role in decisions related to blood transfusions. we sought to examine differences in transfusion practices based on professional role, years of experience, and patient clinical scenario.201627043813
perceptions of older adults, hematologists, and medical oncologists in cancer care.the purpose of this study was to assess and compare the perceptions of hematologists, medical oncologists, cancer patients aged 65 years and older, and family members/caregivers regarding the value of a geriatric assessment (ga) in the management of older adults with cancer.201627043811
a study of tubal recanalization in era of art (assisted reproduction technology).tubectomy remains one of the most popular methods of permanent contraception in developing countries. but about 10% of them regret their decision and 1% want to restore their fertility. out of many options open method of tubal recanalisation is one of the method of restoring fertility.201627042534
increased levels of n(ε)- carboxy methyl lysine (n(ε)-cml) are associated with topographic alterations in retinal pigment epithelium: a preliminary study.to evaluate the association of serum levels of n(ε)- carboxy methyl lysine (n(ε)-cml), an advanced glycation end product with topographic alterations in retinal pigment epithelium (rpe) in diabetic retinopathy on spectral domain optical coherence tomography (sd-oct).201627039312
younger patients report similar activity levels to older patients after reverse total shoulder arthroplasty.younger patients who have undergone reverse total shoulder arthroplasty (rtsa) are believed to have higher activity levels that place higher stresses across the prosthesis, increasing the risk of failure, but there is little information to support or refute this supposition. the purposes of this study were to define the patient-reported activity levels of patients younger than 65 years and older than 65 years who underwent rtsa and to evaluate any differences between the groups.201627038566
an approximate markov model for the wright-fisher diffusion and its application to time series data.the joint and accurate inference of selection and demography from genetic data is considered a particularly challenging question in population genetics, since both process may lead to very similar patterns of genetic diversity. however, additional information for disentangling these effects may be obtained by observing changes in allele frequencies over multiple time points. such data are common in experimental evolution studies, as well as in the comparison of ancient and contemporary samples. ...201627038112
stent-assisted coiling versus coiling alone of ruptured anterior communicating artery aneurysms: a single-center experience.endovascular coiling of anterior communicating artery (acoa) aneurysms has evolved; however, stent-assisted coiling of ruptured aneurysms remains controversial. we aimed to compare periprocedural complications, angiographic and clinical outcomes after stent-assisted coiling with coiling alone of ruptured acoa aneurysms.201627037864
altered cerebellar-cerebral functional connectivity in benign adult familial myoclonic epilepsy.the pathogenesis of benign adult familial myoclonic epilepsy (bafme) remains unknown, although cerebellar pathologic changes and brain hyperexcitability have been reported. we used resting-state functional magnetic resonance imaging (fmri) to examine the functional connectivity between the cerebellum and cerebrum in a chinese family with bafme for the first time.201627037791
management of acute mesenteric ischemia: a critical review and treatment algorithm.acute mesenteric ischemia (ami) due to a sudden loss or decrease in blood perfusion to the mesentery represents a highly lethal condition. however, the optimal surgical management remains debatable and merits a more clear recommendation based on a higher level of evidence.201627036673
sonoelastography in the evaluation of plantar fasciitis treatment: 3-month follow-up after collagen injection.the aim of this study was to investigate whether ultrasound elastography can demonstrate the outcome of the treatment in comparison with gray-scale imaging.201627035685
prediction of outcome after subarachnoid hemorrhage: timing of clinical assessment.objective currently, early prediction of outcome after spontaneous subarachnoid hemorrhage (sah) lacks accuracy despite multiple studies addressing this issue. the clinical condition of the patient on admission as assessed using the world federation of neurosurgical societies (wfns) grading scale is currently considered the gold standard. however, the timing of the clinical assessment is subject to debate, as is the contribution of additional predictors. the aim of this study was to identify eit ...201727035175
meta-analysis and systematic review of risk factors for shunt dependency after aneurysmal subarachnoid hemorrhage.objective aneurysmal subarachnoid hemorrhage (asah) may be complicated by hydrocephalus in 6.5%-67% of cases. some patients with asah develop shunt dependency, which is often managed by ventriculoperitoneal shunt placement. the objectives of this study were to review published risk factors for shunt dependency in patients with asah, determine the level of evidence for each factor, and calculate the magnitude of each risk factor to better guide patient management. methods the authors searched pub ...201727035169
feeding during blood transfusions and the association with necrotizing enterocolitis.objective the aim of this study was to determine whether very low-birth-weight (vlbw) infants who had feedings withheld during all blood transfusions had a lower incidence of necrotizing enterocolitis (nec) compared with infants who were fed during transfusions. study design a retrospective chart review over a 3-year period in a level-3 neonatal intensive care unit was conducted. a total of 108 inborn vlbw infants (weight range: 500-1,500 g) who had received a transfusion before 36 weeks were re ...201627031053
classification of vitreous seeds in retinoblastoma: correlations with patient, tumor, and treatment characteristics.to evaluate the patient, disease, and tumor characteristics of the 3 morphologically distinct groups of vitreous seeds in retinoblastoma presenting for treatment with ophthalmic artery chemosurgery (oac): dust (class 1), spheres (class 2), and clouds (class 3) in primary and recurrent vitreous seeds.201627030103
obesity is not associated with antimicrobial treatment failure for intra-abdominal infection.obesity and commonly associated comorbidities are known risk factors for the development of infections. however, the intensity and duration of antimicrobial treatment are rarely conditioned on body mass index (bmi). in particular, the influence of obesity on failure of antimicrobial treatment for intra-abdominal infection (iai) remains unknown. we hypothesized that obesity is associated with recurrent infectious complications in patients treated for iai.201627027416
diffusion-weighted magnetic resonance imaging in distinguishing between mucin-producing and serous pancreatic cysts.the aim of this study was to evaluate the feasibility and reproducibility of diffusion-weighted imaging in distinguishing between mucin-producing and serous pancreatic cysts.201727023856
the relationship between optic nerve sheath decompression failure and intracranial pressure in idiopathic intracranial hypertension.to our knowledge, there are no studies of patients with idiopathic intracranial hypertension (iih) that address the relationship between level of intracranial pressure (icp) and likelihood of progressive visual loss despite uncomplicated optic nerve sheath decompression (onsd). this study investigated whether patients with iih undergoing onsd had a higher risk of surgical failure if opening pressure (op) on lumbar puncture was ≥50 cm h2o compared to those with op <50 cm h2o.201627023308
comparing the impact of topical application of human milk and chlorhexidine on cord separation time in newborns.the best umbilical cord care after birth is a controversial issue. aim of this research was to compare the effect of topical application of human milk and chlorhexidin on cord separation time in newborns.201727022383
travelling wave analysis of a mathematical model of glioblastoma growth.in this paper we analyse a previously proposed cell-based model of glioblastoma (brain tumour) growth, which is based on the assumption that the cancer cells switch phenotypes between a proliferative and motile state (gerlee and nelander, 2012). the dynamics of this model can be described by a system of partial differential equations, which exhibits travelling wave solutions whose wave speed depends crucially on the rates of phenotypic switching. we show that under certain conditions on the mode ...201627021919
fatigue and its associated factors in spinocerebellar ataxia type 3/machado-joseph disease.fatigue has been described in several neurodegenerative diseases, reducing quality of life. a systematic evaluation of this clinical feature is lacking in sca3/mjd. the aim of this study was to evaluate the frequency and the factors associated with fatigue in sca3/mjd. patients with sca3/mjd and matched healthy controls answered the modified fatigue impact scale (mfis), beck inventory depression (bdi) and epworth sleepiness scale (ess). scale for the assessment and rating of ataxia (sara) was us ...201727021342
effects of intraosseous epinephrine in a cardiac arrest swine model.interruptions in cardiopulmonary resuscitation (cpr) to obtain vascular access reduces blood flow to vital organs. tibial intraosseous (tio) access may be a faster alternative to intravenous (iv) access for delivery of vasoactive medications. the purpose of this study was to examine the differences in pharmacokinetics and pharmacodynamics of tio- and iv-delivered epinephrine.201627020815
higher-order occurrence pooling for bags-of-words: visual concept detection.in object recognition, the bag-of-words model assumes: i) extraction of local descriptors from images, ii) embedding the descriptors by a coder to a given visual vocabulary space which results in mid-level features, iii) extracting statistics from mid-level features with a pooling operator that aggregates occurrences of visual words in images into signatures, which we refer to as first-order occurrence pooling. this paper investigates higher-order pooling that aggregates over co-occurrences of v ...201727019477
genetic drift in populations governed by a galton-watson branching process.most population genetics studies have their origins in a wright-fisher or some closely related fixed-population model in which each individual randomly chooses its ancestor. populations which vary in size with time are typically modelled via a coalescent derived from wright-fisher, but use a nonlinear time-scaling driven by a deterministically imposed population growth. an alternate, arguably more realistic approach, and one which we take here, is to allow the population size to vary stochastica ...201627018000
can anomalous amplification be attained without postselection?we present a parameter estimation technique based on performing joint measurements of a weak interaction away from the weak-value-amplification approximation. two detectors are used to collect full statistics of the correlations between two weakly entangled degrees of freedom. without discarding of data, the protocol resembles the anomalous amplification of an imaginary-weak-value-like response. the amplification is induced in the difference signal of both detectors allowing robustness to differ ...201627015468
comparison of medical versus surgical management of peritonsillar abscess: a retrospective observational study.to compare clinical characteristics and outcomes in patients presenting with peritonsillar abscess (pta) treated with either initial medical or surgical management.201627010228
a multidisciplinary pulmonary embolism response team: initial 30-month experience with a novel approach to delivery of care to patients with submassive and massive pulmonary embolism.integrating newly developed tests and treatments for severe pulmonary embolism (pe) into clinical care requires coordinated multispecialty collaboration. to meet this need, we developed a new paradigm: a multidisciplinary pulmonary embolism response team (pert). in this report, we provide the first longitudinal analysis of patients treated by a pert.201627006156
proliferation indices correlate with diagnosis and metastasis in diagnostically challenging melanocytic tumors.the diagnosis of melanocytic lesions remains a formidable challenge in dermatopathology. for diagnostically challenging lesions, ancillary tests are available to inform the diagnosis, including immunohistochemistry and molecular testing (particularly fluorescence in situ hybridization [fish]). however, the test result that most robustly informs the diagnosis remains controversial. thirty-seven diagnostically challenging melanocytic lesions from our consultation service were reviewed. histopathol ...201627004944
fragmented qrs frequency in patients with cardiac syndrome x.cardiac syndrome x (csx) is characterised by typical exertional chest pain, a positive response to exercise testing, and a normal coronary angiography. the relationship of csx with myocardial fibrosis and ischemia has been clearly demonstrated in previous studies. in addition, fragmented qrs (fqrs) has been reported in the literature as an indicator of myocardial fibrosis. the aim of this study was to investigate the frequency of fqrs in patients with csx.201627004708
epidemiological and radiological evaluation of femoral shaft fractures: study of 200 cases.to evaluate epidemiological and radiological characteristics of the femoral shaft fractures, surgically treated from 1990 to 2005 at hospital de acidentados - clínica santa isabel - in goiânia, goiás, aiming to contribute to better preventive and therapeutic measures planning to adopt on those fractures.200927004172
contribution of fdg pet/ct for the optimization of the management of additional lesions detected on local staging breast mri.the purpose of this study is to evaluate the added value of fdg pet/ct for the management of additional lesions detected by breast mri during initial staging of known breast cancer.201627003055
brachial artery flow mediated dilation and pulsatility index change as independent predictors for hypertensive disorders in the second trimester of pregnancy.to assess brachial artery flow mediated dilatation (fmd) and pulsatility index change (pic) as independent parameters for prediction hypertensive disorders (preeclampsia - pe and gestational hypertension - gh) in the second trimester of pregnancy.201627002727
poped lite: an optimal design software for preclinical pharmacokinetic and pharmacodynamic studies.optimal experimental design approaches are seldom used in preclinical drug discovery. the objective is to develop an optimal design software tool specifically designed for preclinical applications in order to increase the efficiency of drug discovery in vivo studies.201627000295
thioredoxin as a marker for severity and prognosis of aneurysmal subarachnoid hemorrhage.circulating levels of thioredoxin (trx), a potent anti-oxidant that modulates inflammation, cell growth and apoptosis, are increased in various critical care conditions. the purpose of this study was to establish the relationship between serum trx levels and prognosis of aneurysmal subarachnoid hemorrhage (asah).201627000227
late relapses in stage i testicular cancer patients on surveillance.comprehensive data on late relapse (lr) and very lr (vlr) in patients with clinical stage i (cs-1) testicular cancer followed on surveillance are missing. these data are essential for planning optimal follow-up.201626996661
detection of merkel cell polyomavirus and human papillomavirus dna in porocarcinoma.increasing evidences support the role of merkel cell polyomavirus (mcpyv) and human papillomavirus (hpv) in non-cutaneous and cutaneous tumours. porocarcinoma is a rare malignant neoplasm that arises from the intraepidermal ductal portion of the eccrine sweat glands. the aetiology of porocarcinoma is largely unknown and no systematic studies have been done to investigate the implication of infectious agents in the pathogenesis of this tumour.201626994694
histologic findings after mechanochemical ablation in a caprine model with use of clarivein.the use of foam and liquid sclerotherapy for the treatment of varicose veins and underlying venous reflux is widespread. a novel device, the clarivein occlusion catheter (vascular insights llc, madison, conn), has been the subject of several clinical trials in humans. we report the initial histologic results obtained with use of the device in a caprine vein model.201526993685
anatomic and functional outcomes of pharmacomechanical and catheter-directed thrombolysis of iliofemoral deep venous thrombosis.pharmacomechanical thrombolysis (pmt) and catheter-directed thrombolysis (cdt) are commonly used for the treatment of iliofemoral deep venous thrombosis (dvt). the purpose of this study was to examine the short- and long-term venous patency and venous valvular function as well as clinical outcomes of patients treated for iliofemoral dvt by pmt and cdt.201426993382
complications of indwelling retrievable versus permanent inferior vena cava filters.retrievable inferior vena cava (ivc) filters are appealing because they are designed for either retrieval or long-term use. however, the long-term safety of indwelling retrievable compared with permanent filters is largely unknown. this study was undertaken to compare complication rates and types associated with indwelling retrievable and permanent filters.201426993182
periodontal status in morbidly obese patients with and without obstructive sleep apnea syndrome risk: a cross-sectional study.this cross-sectional study aims to investigate the correlation between obstructive sleep apnea syndrome (osas) risk with periodontal disease and anthropometric measures in class iii obese patients.201626991486
detecting large quantum fisher information with finite measurement precision.we propose an experimentally accessible scheme to determine the lower bounds on the quantum fisher information (qfi), which ascertains multipartite entanglement or usefulness for quantum metrology. the scheme is based on comparing the measurement statistics of a state before and after a small unitary rotation. we argue that, in general, the limited resolution of collective observables prevents the detection of large qfi. this can be overcome by performing an additional operation prior to the mea ...201626991166
label-noise resistant logistic regression for functional data classification with an application to alzheimer's disease study.alzheimer's disease (ad) is usually diagnosed by clinicians through cognitive and functional performance test with a potential risk of misdiagnosis. since the progression of ad is known to cause structural changes in the corpus callosum (cc), the cc thickness can be used as a functional covariate in ad classification problem for a diagnosis. however, misclassified class labels negatively impact the classification performance. motivated by ad-cc association studies, we propose a logistic regressi ...201626990925
evaluation of presumably disease causing scn1a variants in a cohort of common epilepsy syndromes.the scn1a gene, coding for the voltage-gated na+ channel alpha subunit nav1.1, is the clinically most relevant epilepsy gene. with the advent of high-throughput next-generation sequencing, clinical laboratories are generating an ever-increasing catalogue of scn1a variants. variants are more likely to be classified as pathogenic if they have already been identified previously in a patient with epilepsy. here, we critically re-evaluate the pathogenicity of this class of variants in a cohort of pat ...201626990884
delta method and bootstrap in linear mixed models to estimate a proportion when no event is observed: application to intralesional resection in bone tumor surgery.resecting bone tumors requires good cutting accuracy to reduce the occurrence of local recurrence. this issue is considerably reduced with a navigated technology. the estimation of extreme proportions is challenging especially with small or moderate sample sizes. when no success is observed, the commonly used binomial proportion confidence interval is not suitable while the rule of three provides a simple solution. unfortunately, these approaches are unable to differentiate between different uno ...201626990871
complex-valued time-series correlation increases sensitivity in fmri analysis.to develop a linear matrix representation of correlation between complex-valued (cv) time-series in the temporal fourier frequency domain, and demonstrate its increased sensitivity over correlation between magnitude-only (mo) time-series in functional mri (fmri) analysis.201626988705
comparison on the use of semi-automated and automated core biopsy needle in ultrasound guided breast biopsy.the aim of this study was to compare the use of semi-automated (medax velox 2; poggio rusco, italy) and automated (bard magnum biopsy instrument; covington, ga, usa) core biopsy needles, for ultrasound guided breast biopsy.201526988204
a critical review of 20 years of parotid gland surgery.conclusion pg surgery provides sufficient radicality with a minimum of functional loss. patient's outcome is associated with the reliable estimation of the lesional entity/dignity. diagnostic approaches are required to determine morphological aspects, avoid unnecessary surgery, and to reliable identify primary carcinomas/occult metastases. objectives the pre-operative assessment of parotid gland (pg) lesions is of major clinical impact, whilst surgery remains the diagnostic/therapeutic mainstay. ...201626986955
nonparametric estimation of fisher information from real data.the fisher information matrix (fim) is a widely used measure for applications including statistical inference, information geometry, experiment design, and the study of criticality in biological systems. the fim is defined for a parametric family of probability distributions and its estimation from data follows one of two paths: either the distribution is assumed to be known and the parameters are estimated from the data or the parameters are known and the distribution is estimated from the data ...201626986433
confirmatory evidence for a multidimensional model of racial-ethnic socialization for transracially adoptive families.the purpose of the current study is to test a recently established model of racial-ethnic socialization (langrehr, 2014) among 2 samples of white transracially adoptive parents and to assess whether the proposed model functions similarly after accounting for adopted child race.201626985870
prediction of 60-day case fatality after aneurysmal subarachnoid hemorrhage: external validation of a prediction model.external validation of prognostic models is crucial but rarely done. our aim was to externally validate a prognostic model to predict 60-day case fatality after aneurysmal subarachnoid hemorrhage developed from the international subarachnoid aneurysm trial in a retrospective unselected cohort of subarachnoid hemorrhage patients.201626985635
serum and csf gq1b antibodies in isolated ophthalmologic syndromes.to establish the sensitivity and specificity of serum and csf antibodies targeting the gangliosides gq1b (gq1bab) in isolated ophthalmologic syndromes, such as acute ophthalmoplegia (ao) and optic neuritis (on), caused by disorders other than miller-fisher syndrome (mfs).201626984947
comparison of hiv testing uptake in an urban academic emergency department using different testing assays and support systems.despite 2006 recommendations by the centers for disease control and prevention for opt-out hiv testing in all healthcare settings, emergency department (ed) testing has been limited. we conducted an observational cohort study to assess the impact of two workflow interventions on the proportion of hiv tests ordered in an urban academic ed. first, a 4(th)-generation hiv antigen/antibody combination test replaced the existing assay, and ed staff continued to notify patients of their reactive tests. ...201626982908
detection of mycobacterium ulcerans dna in the environment, ivory coast.ivory coast is a west african country with the highest reported cases of buruli ulcer, a disabling subcutaneous infection due to mycobacterium ulcerans. however, the prevalence of environmental m. ulcerans is poorly known in this country.201626982581
the inverted discoid meniscus segment: clinical, radiographic, and arthroscopic description of a hidden tear pattern.a flipped, or inverted, meniscus segment is easily visualized in the normal meniscus. however, an inverted discoid meniscus segment may be difficult to appreciate because the tear occurs more centrally and leaves more meniscal rim; thus, it may be undertreated if not addressed during arthroscopy.201626980846
aberrant activation-induced cytidine deaminase expression in philadelphia chromosome-positive b-cell acute lymphoblastic leukemia.activation-induced cytidine deaminase (aid) is expressed in germinal center b cells and plays a critical role in somatic hypermutation and class-switch recombination of immunoglobulin genes. philadelphia chromosome-positive (ph+) acute lymphoblastic leukemia (all) carries a poor prognosis and is specifically treated with tyrosine kinase inhibitors. interestingly, aid has been shown to be aberrantly expressed and functional in ph+ all and is thought to contribute to genetic instability. we hypoth ...201626980048
a morphological and immunophenotypic map of the immune response in merkel cell carcinoma.the susceptibility of merkel cell carcinoma to the host immune response has prompted a search for effective immunotherapy. cd8-positive t lymphocytes are considered key effectors of this response, but the cellular infiltrates also harbor tumor-protective agents. by developing a comprehensive morphological and immunophenotypic map of tumor-infiltrating lymphocytes (tils) in merkel cell carcinoma, we aimed to establish a useful template for future studies. twenty-two cases (mean age, 79years [rang ...201626980039
neurofibromin protein loss in desmoplastic melanoma subtypes: implicating nf1 allelic loss as a distinct genetic driver?loss of the nf1 allele, coding for the protein neurofibromin, and polymorphism in the proto-oncogene ret (retp) are purportedly common in desmoplastic melanoma (dm). dm is categorized into pure (pdm) and mixed (mdm) subtypes, which differ in prognosis. most nf1 mutations result in a truncated/absent protein, making immunohistochemical screening for neurofibromin an ideal surrogate for nf1 allelic loss. using antineurofibromin, our aims were to ascertain the incidence of neurofibromin loss in dm ...201626980030
efficient estimators for likelihood ratio sensitivity indices of complex stochastic dynamics.we demonstrate that centered likelihood ratio estimators for the sensitivity indices of complex stochastic dynamics are highly efficient with low, constant in time variance and consequently they are suitable for sensitivity analysis in long-time and steady-state regimes. these estimators rely on a new covariance formulation of the likelihood ratio that includes as a submatrix a fisher information matrix for stochastic dynamics and can also be used for fast screening of insensitive parameters and ...201626979681
enhancer of zeste homolog 2 (ezh2) expression in bladder cancer.studies evaluating enhancer of zeste homolog 2 (ezh2) expression and oncologic outcomes in bladder cancer have been discrepant. ezh2 expression in noninvasive bladder cancer is not well studied. we thus set out to address the discrepancy in previous reports, and to study expression of ezh2 in noninvasive bladder cancer and its associations, in a large cystectomy cohort.201626976725
descriptors of malignant non-mass enhancement of breast mri: their correlation to the presence of invasion.this study aims to investigate the clinical significance of malignant non-mass enhancement (nme) descriptors in breast magnetic resonance images by assessing their correlation to the presence of invasion or lymph node metastasis.201626976623
assessment of long-term bowel symptoms after segmental resection of deeply infiltrating endometriosis: a matched cohort study.to assess long-term bowel symptoms in women who underwent segmental bowel resection for deep-infiltrating endometriosis (die) compared with women who underwent resection of severe endometriosis without bowel resection.201726976198
[aneurysmal subarachnoid haemorrhage: results after introducing endovascular therapy in a medium-low volume centre].to evaluate the impact of introducing endovascular therapy for patients with aneurysmal subarachnoid haemorrhage (asah) in a medium-low volume centre.201626975879
bacterial regulon modeling and prediction based on systematic cis regulatory motif analyses.regulons are the basic units of the response system in a bacterial cell, and each consists of a set of transcriptionally co-regulated operons. regulon elucidation is the basis for studying the bacterial global transcriptional regulation network. in this study, we designed a novel co-regulation score between a pair of operons based on accurate operon identification and cis regulatory motif analyses, which can capture their co-regulation relationship much better than other scores. taking full adva ...201626975728
gender recognition from facial images: two or three dimensions?this paper seeks to compare encoded features from both two-dimensional (2d) and three-dimensional (3d) face images in order to achieve automatic gender recognition with high accuracy and robustness. the fisher vector encoding method is employed to produce 2d, 3d, and fused features with escalated discriminative power. for 3d face analysis, a two-source photometric stereo (ps) method is introduced that enables 3d surface reconstructions with accurate details as well as desirable efficiency. moreo ...201626974902
integrating simultaneous prosocial and antisocial behavior into theories of collective action.trust and cooperation constitute cornerstones of common-pool resource theory, showing that "prosocial" strategies among resource users can overcome collective action problems and lead to sustainable resource governance. yet, antisocial behavior and especially the coexistence of prosocial and antisocial behaviors have received less attention. we broaden the analysis to include the effects of both "prosocial" and "antisocial" interactions. we do so in the context of marine protected areas (mpas), ...201626973871
changes in the expression of calcitonin gene-related peptide after exposure to injurious stretch-shortening contractions.one of the factors that can result in musculoskeletal injuries, and time off work, is exposure to repetitive motion. the goal of this study was to determine if skeletal muscle injury induced by exposure to injurious stretch-shortening cycles (isscs), resulted in hyperalgesia in the hind limb and changes in calcitonin-gene related peptide (cgrp) immunolabeling in the dorsal root ganglia (drg) in young and old male rats.201626972633
differential network analysis reveals the genome-wide landscape of estrogen receptor modulation in hormonal cancers.several mutual information (mi)-based algorithms have been developed to identify dynamic gene-gene and function-function interactions governed by key modulators (genes, proteins, etc.). due to intensive computation, however, these methods rely heavily on prior knowledge and are limited in genome-wide analysis. we present the modulated gene/gene set interaction (magic) analysis to systematically identify genome-wide modulation of interaction networks. based on a novel statistical test employing c ...201626972162
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