Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| salmonella enterica paratyphi a infections in travelers returning from cambodia, united states. | 2015 | 25988984 | |
| salmonella enterica serotype enteritidis in french polynesia, south pacific, 2008-2013. | outbreaks of salmonella enterica serotype enteritidis infections associated with eggs occurred in french polynesia during 2008-2013. molecular analysis of isolates by using clustered regularly interspaced short palindromic repeat polymorphisms and multilocus variable-number tandem-repeat analysis was performed. this subtyping made defining the epidemic strain, finding the source, and decontaminating affected poultry flocks possible. | 2015 | 25988406 |
| importance of sigma factor mutations in increased triclosan resistance in salmonella typhimurium. | salmonella enterica is the second most common foodborne pathogen. the use of biocides is crucial to prevent spread of foodborne pathogens, and it would be devastating for food safety if salmonella would become resistant to the disinfectants used. another concern is that exposure to disinfectants might lead to decreased susceptibility to antibiotics. the current study aimed to identify genetic changes causing high level triclosan resistance in s. enterica serovar typhimurium and evaluate how thes ... | 2015 | 25986727 |
| editorial on plants as alternative hosts for human and animal pathogens. | 2015 | 25983729 | |
| catecholate siderophore esterases fes, irod and iroe are required for salmochelins secretion following utilization, but only irod contributes to virulence of extra-intestinal pathogenic escherichia coli. | salmochelins are glucosylated forms of enterobactin (enterochelin) and contribute to the virulence of salmonella enterica and some extra-intestinal pathogenic escherichia coli (expec). fes, irod and iroe esterases degrade salmochelins and enterobactin to release iron. we investigated the apparently redundant role of these esterases in virulence and in salmochelin production and utilization of the expec strain χ7122. the δirod, δfesδirod and δfesδirodδiroe mutants displayed attenuated virulence p ... | 2015 | 25982934 |
| high-throughput crispr typing of mycobacterium tuberculosis complex and salmonella enterica serotype typhimurium. | spoligotyping was developed almost 18 years ago and still remains a popular first-lane genotyping technique to identify and subtype mycobacterium tuberculosis complex (mtc) clinical isolates at a phylogeographic level. for other pathogens, such as salmonella enterica, recent studies suggest that specifically designed spoligotyping techniques could be interesting for public health purposes. spoligotyping was in its original format a reverse line-blot hybridization method using capture probes desi ... | 2015 | 25981468 |
| absence of multidrug resistance in salmonella enterica serotypes typhi and paratyphi a isolates with intermediate susceptibility to ciprofloxacin. | we describe the antimicrobial susceptibility pattern of 64 blood stream isolates of salmonella enterica serotypes typhi and paratyphi a studied from january 2013 to december 2014 at a tertiary care centre in north india. | 2015 | 25979527 |
| genomic and experimental evidence for multiple metabolic functions in the rida/yjgf/yer057c/uk114 (rid) protein family. | it is now recognized that enzymatic or chemical side-reactions can convert normal metabolites to useless or toxic ones and that a suite of enzymes exists to mitigate such metabolite damage. examples are the reactive imine/enamine intermediates produced by threonine dehydratase, which damage the pyridoxal 5'-phosphate cofactor of various enzymes causing inactivation. this damage is pre-empted by rida proteins, which hydrolyze the imines before they do harm. rida proteins belong to the yjgf/yer057 ... | 2015 | 25975565 |
| preliminary incidence and trends of infection with pathogens transmitted commonly through food - foodborne diseases active surveillance network, 10 u.s. sites, 2006-2014. | foodborne illnesses represent a substantial, yet largely preventable, health burden in the united states. in 10 u.s. geographic areas, the foodborne diseases active surveillance network (foodnet) monitors the incidence of laboratory-confirmed infections caused by nine pathogens transmitted commonly through food. this report summarizes preliminary 2014 data and describes changes in incidence compared with 2006-2008 and 2011-2013. in 2014, foodnet reported 19,542 infections, 4,445 hospitalizations ... | 2015 | 25974634 |
| multidrug-resistant salmonella enterica serovar typhimurium monophasic variant 4,12:i:- isolated from asymptomatic wildlife in a catalonian wildlife rehabilitation center, spain. | wildlife can act as long-term asymptomatic reservoirs for zoonotic bacteria, such as salmonella. the prevalence and antimicrobial-susceptibility profiles of salmonella spp. were assessed in 263 cases in wildlife from 22 animal orders from a wildlife rehabilitation center in catalonia (ne spain), september 2013-may 2014. eleven of 263 tested animals were positive for salmonella spp., representing an overall prevalence of 4.2%. prevalences by taxonomic categories were 2% in mammals, 4.7% in birds, ... | 2015 | 25973627 |
| mathematical model of flagella gene expression dynamics in salmonella enterica serovar typhimurium. | flagellar assembly in salmonella is controlled by an intricate genetic and biochemical network. this network comprises of a number of inter-connected feedback loops, which control the assembly process dynamically. critical among these are the flia-flgm feedback, fliz-mediated positive feedback, and flit-mediated negative feedback. in this work, we develop a mathematical model to track the dynamics of flagellar gene expression in salmonella. analysis of our model demonstrates that the network is ... | 2015 | 25972986 |
| host cell type-dependent translocation and phop-mediated positive regulation of the effector ssek1 of salmonella enterica. | salmonella enterica expresses two virulence-related type iii secretion systems (t3sss) encoded in salmonella pathogenicity island 1 (spi1) and spi2, respectively. ssek1 is a poorly characterized substrate of the spi2-encoded t3ss. here, we show that this effector is essential to get full virulence both in oral and intraperitoneal mice infections, in spite of not having a role in invasion or intracellular proliferation in cultured mammalian cells. in vitro, expression of ssek1 was higher in media ... | 2015 | 25972862 |
| a novel microbial source tracking microarray for pathogen detection and fecal source identification in environmental systems. | pathogen detection and the identification of fecal contamination sources are challenging in environmental waters. factors including pathogen diversity and ubiquity of fecal indicator bacteria hamper risk assessment and remediation of contamination sources. a custom microarray targeting pathogens (viruses, bacteria, protozoa), microbial source tracking (mst) markers, and antibiotic resistance genes was tested against dna obtained from whole genome amplification (wga) of rna and dna from sewage an ... | 2015 | 25970344 |
| a new repertoire of informations about the quorum sensing system in salmonella enterica serovar enteritidis pt4. | salmonella spp are among the main causative agents of foodborne diseases. some phenotypes associated with increased drug resistance and virulence are regulated by quorum sensing (qs). in the present study, the autoinducer (ai)-1- and -2-mediated qs mechanisms were characterized in salmonella enterica serovar enteritidis pt4 for the first time. salmonella enteritidis did not produce ai-1. phylogenetic analysis of nucleotides encoding the sdia protein, the response regulator of ai-1-mediated qs, a ... | 2015 | 25966179 |
| interaction of salmonella enterica serovar typhimurium with intestinal organoids derived from human induced pluripotent stem cells. | the intestinal mucosa forms the first line of defense against infections mediated by enteric pathogens such as salmonellae. here we exploited intestinal "organoids" (ihos) generated from human induced pluripotent stem cells (hipscs) to explore the interaction of salmonella enterica serovar typhimurium with ihos. imaging and rna sequencing were used to analyze these interactions, and clear changes in transcriptional signatures were detected, including altered patterns of cytokine expression after ... | 2015 | 25964470 |
| trends in antibiotic susceptibility of enteric fever isolates in east london. | the study sought evidence for changes in the proportions of antibiotic resistant strains among isolates of salmonella enterica serovar typhi (s. typhi) and salmonella enterica serovar paratyphi (s. paratyphi) between 2005 and 2012. | 2015 | 25964222 |
| antimicrobial susceptibility of travel-related salmonella enterica serovar typhi isolates detected in switzerland (2002-2013) and molecular characterization of quinolone resistant isolates. | typhoid fever is an acute, invasive, and potentially fatal systemic infection caused by salmonella enterica subspecies enterica serotype typhi (s. typhi). drug resistance to antimicrobials such as ciprofloxacin is emerging in developing countries, threatening the efficacy of treatment of patients in endemic regions as well as of travellers returning from these countries. | 2015 | 25963025 |
| outbreak of salmonella enterica serovar typhimurium phage type dt41 in danish poultry production. | salmonella enterica subspecies enterica serovar typhimurium (s. typhimurium) is one of the most prevalent serovars in europe - where both poultry and poultry related products are common sources of human salmonellosis. due to efficient control programs, the prevalence of s. typhimurium in danish poultry production is very low. despite this, during the past decades there has been a reoccurring problem with infections with s. typhimurium phage type dt41 in the danish poultry production without iden ... | 2015 | 25962983 |
| the pdul phosphotransacylase is used to recycle coenzyme a within the pdu microcompartment. | in salmonella enterica, 1,2-propanediol (1,2-pd) utilization (pdu) is mediated by a bacterial microcompartment (mcp). the pdu mcp consists of a multiprotein shell that encapsulates enzymes and cofactors for 1,2-pd catabolism, and its role is to sequester a reactive intermediate (propionaldehyde) to minimize cellular toxicity and dna damage. for the pdu mcp to function, the enzymes encapsulated within must be provided with a steady supply of substrates and cofactors. in the present study, western ... | 2015 | 25962918 |
| in salmonella enterica, ethanolamine utilization is repressed by 1,2-propanediol to prevent detrimental mixing of components of two different bacterial microcompartments. | bacterial microcompartments (mcps) are a diverse family of protein-based organelles composed of metabolic enzymes encapsulated within a protein shell. the function of bacterial mcps is to optimize metabolic pathways by confining toxic and/or volatile metabolic intermediates. about 20% of bacteria produce mcps, and there are at least seven different types. different mcps vary in their encapsulated enzymes, but all have outer shells composed of highly conserved proteins containing bacterial microc ... | 2015 | 25962913 |
| phylogeographical analysis of the dominant multidrug-resistant h58 clade of salmonella typhi identifies inter- and intracontinental transmission events. | the emergence of multidrug-resistant (mdr) typhoid is a major global health threat affecting many countries where the disease is endemic. here whole-genome sequence analysis of 1,832 salmonella enterica serovar typhi (s. typhi) identifies a single dominant mdr lineage, h58, that has emerged and spread throughout asia and africa over the last 30 years. our analysis identifies numerous transmissions of h58, including multiple transfers from asia to africa and an ongoing, unrecognized mdr epidemic ... | 2015 | 25961941 |
| mechanisms of antimicrobial resistant salmonella enterica transmission associated with starling-livestock interactions. | bird-livestock interactions have been implicated as potential sources for bacteria within concentrated animal feeding operations (cafo). european starlings (sturnus vulgaris) in particular are known to contaminate cattle feed and water with salmonella enterica through their fecal waste. we propose that fecal waste is not the only mechanisms through which starlings introduce s. enterica to cafo. the goal of this study was to assess if starlings can mechanically move s. enterica. we define mechani ... | 2015 | 25960334 |
| biochemical and kinetic characterization of the eukaryotic phosphotransacetylase class iia enzyme from phytophthora ramorum. | phosphotransacetylase (pta), a key enzyme in bacterial metabolism, catalyzes the reversible transfer of an acetyl group from acetyl phosphate to coenzyme a (coa) to produce acetyl-coa and pi. two classes of pta have been identified based on the absence (pta(i)) or presence (pta(ii)) of an n-terminal regulatory domain. pta(i) has been fairly well studied in bacteria and one genus of archaea; however, only the escherichia coli and salmonella enterica pta(ii) enzymes have been biochemically charact ... | 2015 | 25956919 |
| sexually acquired salmonella typhi urinary tract infection. | we report a case of isolated urinary salmonella enterica serotype typhi in an hiv-positive man who has sex with men. he was clinically well and blood and stool cultures were negative, indicating that this may have been a sexually acquired urinary tract infection. | 2016 | 25953964 |
| older leaves of lettuce (lactuca spp.) support higher levels of salmonella enterica ser. senftenberg attachment and show greater variation between plant accessions than do younger leaves. | salmonella can bind to the leaves of salad crops including lettuce and survive for commercially relevant periods. previous studies have shown that younger leaves are more susceptible to colonization than older leaves and that colonization levels are dependent on both the bacterial serovar and the lettuce cultivar. in this study, we investigated the ability of two lactuca sativa cultivars (saladin and iceberg) and an accession of wild lettuce (l. serriola) to support attachment of salmonella ente ... | 2015 | 25953858 |
| parallel evolutionary pathways to antibiotic resistance selected by biocide exposure. | biocides are widely used to prevent infection. we aimed to determine whether exposure of salmonella to various biocides could act as a driver of antibiotic resistance. | 2015 | 25953808 |
| a handheld flow genetic analysis system (fgas): towards rapid, sensitive, quantitative and multiplex molecular diagnosis at the point-of-care level. | a handheld flow genetic analysis system (fgas) is proposed for rapid, sensitive, multiplex and real-time quantification of nucleic acids at the point-of-care (poc) level. the fgas includes a helical thermal-gradient microreactor and a microflow actuator, as well as control circuitry for temperature, fluid and power management, and smartphone fluorescence imaging. all of these features are integrated into a field-portable and easy-to-use molecular diagnostic platform powered by lithium batteries. ... | 2015 | 25953325 |
| genome sequence of salmonella enterica phage det7. | det7 is a myoviridae bacteriophage that gains entry into its salmonella enterica serovar typhimurium host cells by adsorbing to o-antigen polysaccharide. we report here the complete 157,498-bp sequence of its genome. det7, together with its vi01-like relatives, are distantly related to phage t4. | 2015 | 25953168 |
| salmonella in raw chicken meat from the romanian seaside: frequency of isolation and antibiotic resistance. | the purpose of this study was to investigate the occurrence of salmonella in raw chicken meat samples collected at the romanian seaside and to evaluate the antimicrobial susceptibility of the isolates. in 2012, 317 chicken meat samples from slaughterhouses (n = 289) and retail markets (n = 28) were evaluated. overall, 13.2% (42) of the samples contained salmonella; 12.8% (37) and 17.8% (5) from the chicken carcasses at slaughterhouses and the fresh meat from retail markets, respectively. eight s ... | 2015 | 25951397 |
| multiplex pcr-based serogrouping and serotyping of salmonella enterica from tonsil and jejunum with jejunal lymph nodes of slaughtered swine in metro manila, philippines. | food poisoning outbreaks and livestock mortalities caused by salmonella enterica are widespread in the philippines, with hogs being the most commonly recognized carriers of the pathogen. to prevent and control the occurrence of s. enterica infection in the country, methods were used in this study to isolate and rapidly detect, differentiate, and characterize s. enterica in tonsils and jejuna with jejunal lymph nodes of swine slaughtered in four locally registered meat establishments (lrmes) and ... | 2015 | 25951380 |
| development of combined dry heat and chlorine dioxide gas treatment with mechanical mixing for inactivation of salmonella enterica serovar montevideo on mung bean seeds. | foodborne outbreaks have been associated with the consumption of fresh sprouted beans. the sprouting conditions of mung bean seeds provide optimal conditions of temperature and relative humidity for any potential pathogenic contaminant on the seeds to grow. the lack of a kill step postsprouting is a major safety concern. thus, the use of a kill step on the seeds prior to a sprouting step would enhance the safety of fresh sprouts. the objective of this work was to evaluate the effectiveness of th ... | 2015 | 25951379 |
| improvement of bacterial clearance and relief of clinical signs of salmonella enterica serovar typhimurium infection in pigs through upregulation of th 1-specific responses by administration of a combination of two silicate minerals, biotite and bentonite. | biotite and bentonite are phyllosilicate minerals that were originally used in industrial applications. several beneficial activities of them have recently been reported, especially regulation of the immune system and antimicrobial effects. therefore, we investigated the immune-enhancing and bacterial clearance effects of a biotite and bentonite mixture (bbm) on experimental infection of salmonella enterica serovar typhimurium (s. typhimurium) to determine whether the bbm could be used as an alt ... | 2015 | 25947887 |
| variable responses to carbon utilization between planktonic and biofilm cells of a human carrier strain of salmonella enterica serovar typhi. | salmonella enterica serovar typhi (s. typhi) is a foodborne pathogen that causes typhoid fever and infects only humans. the ability of s. typhi to survive outside the human host remains unclear, particularly in human carrier strains. in this study, we have investigated the catabolic activity of a human carrier s. typhi strain in both planktonic and biofilm cells using the high-throughput biolog phenotype microarray, minimum biofilm eradication concentration (mbec) biofilm inoculator (96-well peg ... | 2015 | 25946205 |
| liver abscess caused by salmonella choleraesuis. | a 65-year-old man with long-term alcohol abuse presented with intermittent fever. abdominal computed tomography revealed multiple masses. abscess blood and pus cultures conducted after percutaneous catheter drainage with pigtail catheters yielded salmonella choleraesuis. antibiotic treatment with meropenem was started using multiple catheters in the liver. drainage catheters in different locations were exchanged several times with larger-bored catheters. after septicemia was detected, abscesses ... | 2015 | 25945064 |
| (1)h, (13)c and (15)n resonance assignments of σ(s) activating protein crl from salmonella enterica serovar typhimurium. | the general stress response in enterobacteria, like escherichia coli or salmonella, is controlled by the transcription factor σ(s), encoded by the rpos gene, which accumulates during stationary phase growth and associates with the core rna polymerase enzyme (e) to promote transcription of genes involved in cell survival. tight regulation of σ(s) is essential to preserve the balance between self-preservation under stress conditions and nutritional competence in the absence of stress. whereas σ fa ... | 2015 | 25943268 |
| proteomic analyses of intracellular salmonella enterica serovar typhimurium reveal extensive bacterial adaptations to infected host epithelial cells. | salmonella species can gain access into nonphagocytic cells, where the bacterium proliferates in a unique membrane-bounded compartment. in order to reveal bacterial adaptations to their intracellular niche, here we conducted the first comprehensive proteomic survey of salmonella isolated from infected epithelial cells. among ∼ 3,300 identified bacterial proteins, we found that about 100 proteins were significantly altered at the onset of salmonella intracellular replication. in addition to subst ... | 2015 | 25939512 |
| use of metagenomics and isolation of actinobacteria in brazil's atlantic rainforest soil for antimicrobial prospecting. | modern techniques involving molecular biology, such as metagenomics, have the advantage of exploiting a higher number of microorganisms; however, classic isolation and culture methods used to obtain antimicrobials continue to be promising, especially in the isolation of actinobacteria, which are responsible for the production of many of these compounds. in this work, two methodologies were used to search for antimicrobial substances-isolation of actinobacteria and metagenomics of the atlantic ra ... | 2014 | 25937991 |
| association with pathogenic bacteria affects life-history traits and population growth in caenorhabditis elegans. | determining the relationship between individual life-history traits and population dynamics is an essential step to understand and predict natural selection. model organisms that can be conveniently studied experimentally at both levels are invaluable to test the rich body of theoretical literature in this area. the nematode caenorhabditis elegans, despite being a well-established workhorse in genetics, has only recently received attention from ecologists and evolutionary biologists, especially ... | 2015 | 25937908 |
| diagnostics for invasive salmonella infections: current challenges and future directions. | invasive salmonellosis caused by salmonella enterica serotype typhi or paratyphi a, b, c, or invasive non-typhoidal salmonella serotypes, is an immensely important disease cluster for which reliable, rapid diagnostic tests are not available. blood culture remains the gold standard but is insensitive, slow, and resource-intensive. existing molecular diagnostics have poor sensitivity due to the low organism burden in bodily fluids. commercially available serologic tests for typhoidal salmonella ha ... | 2015 | 25937611 |
| la35 poultry fecal marker persistence is correlated with that of indicators and pathogens in environmental waters. | disposal of fecally contaminated poultry litter by land application can deliver pathogens and fecal indicator bacteria (fib) into receiving waters via runoff. while water quality is regulated by fib enumeration, fib testing provides inadequate information about contamination source and health risk. this microbial source tracking (mst) study compared the persistence of the brevibacterium sp. strain la35 16s rrna gene (marker) for poultry litter with that of pathogens and fib under outdoor, enviro ... | 2015 | 25934617 |
| differentiation of incl and incm plasmids associated with the spread of clinically relevant antimicrobial resistance. | blaoxa-48, blandm-1 and blactx-m-3 are clinically relevant resistance genes, frequently associated with the broad-host range plasmids of the incl/m group. the l and m plasmids belong to two compatible groups, which were incorrectly classified together by molecular methods. in order to understand their evolution, we fully sequenced four incl/m plasmids, including the reference plasmids r471 and r69, the recently described blaoxa-48-carrying plasmid pkpn-el.nr7 from a klebsiella pneumoniae isolate ... | 2015 | 25933288 |
| dual 3'seq using deepsupersage uncovers transcriptomes of interacting salmonella enterica typhimurium and human host cells. | the interaction of eukaryotic host and prokaryotic pathogen cells is linked to specific changes in the cellular proteome, and consequently to infection-related gene expression patterns of the involved cells. to simultaneously assess the transcriptomes of both organisms during their interaction we developed dual 3'seq, a tag-based sequencing protocol that allows for exact quantification of differentially expressed transcripts in interacting pro- and eukaryotic cells without prior fixation or phys ... | 2015 | 25927313 |
| species interactions differ in their genetic robustness. | conflict and cooperation between bacterial species drive the composition and function of microbial communities. stability of these emergent properties will be influenced by the degree to which species' interactions are robust to genetic perturbations. we use genome-scale metabolic modeling to computationally analyze the impact of genetic changes when escherichia coli and salmonella enterica compete, or cooperate. we systematically knocked out in silico each reaction in the metabolic network of e ... | 2015 | 25926820 |
| photodynamic inactivation mediated by erythrosine and its derivatives on foodborne pathogens and spoilage bacteria. | the purpose of the present study was to evaluate the efficacy of photodynamic inactivation (pdi) mediated by erythrosine (ery) and its ester derivatives erythrosine methyl ester (erymet) and erythrosine butyl ester (erybut) on foodborne pathogens and spoilage bacteria. we evaluated staphylococcus aureus atcc 25923, aeromonas hydrophila atcc 7966, salmonella enterica serotype typhimurium atcc 14028, escherichia coli atcc 25922, and pseudomonas aeruginosa atcc 27853. the toxicity of all of the com ... | 2015 | 25925153 |
| identification and antimicrobial activity detection of lactic acid bacteria isolated from corn stover silage. | a total of 59 lactic acid bacteria (lab) strains were isolated from corn stover silage. according to phenotypic and chemotaxonomic characteristics, 16s ribosomal dna (rdna) sequences and reca gene polymerase chain reaction amplification, these lab isolates were identified as five species: lactobacillus (l.) plantarum subsp. plantarum, pediococcus pentosaceus, enterococcus mundtii, weissella cibaria and leuconostoc pseudomesenteroides, respectively. those strains were also screened for antimicrob ... | 2015 | 25924957 |
| evaluation of the salmonella enterica serovar pullorum pathogenicity island 2 mutant as a candidate live attenuated oral vaccine. | salmonella enterica serovar pullorum (s. pullorum) is a highly adapted pathogen that causes pullorum disease (pd), an important systemic disease of poultry that causes severe economic losses in developing countries. in the interests of developing a safe and immunogenic oral vaccine, the efficacy of a salmonella pathogenicity island 2 (spi2)-deleted mutant of s. pullorum (s06004δspi2) was evaluated in chickens. s06004δspi2 was severely less virulent than the parental wild-type strain s06004 as de ... | 2015 | 25924763 |
| resistance-gene cassettes associated with salmonella enterica genotypes. | the epidemiology of salmonellosis is complex because of the diversity and different serotypes of salmonella enterica (s. enterica) that occur in different reservoirs and geographic incidences. | 2015 | 25918187 |
| two novel salmonella genomic island 1 variants in proteus mirabilis isolates from swine farms in china. | four different salmonella genomic island 1 (sgi1) variants, including two novel variants, were characterized in one salmonella enterica serovar rissen sequence type st1917 isolate and three proteus mirabilis isolates from swine farms in china. one novel variant was derived from sgi1-b with the backbone gene s021 disrupted by a 12.72-kb is26 composite transposon containing the dfra17-aada5 cassettes and macrolide inactivation gene cluster mpha-mrx-mphr. the other one was an integron-free sgi1 and ... | 2015 | 25918148 |
| tn6026 and tn6029 are found in complex resistance regions mobilised by diverse plasmids and chromosomal islands in multiple antibiotic resistant enterobacteriaceae. | transposons flanked by direct copies of is26 are important contributors to the evolution of multiple antibiotic resistance. tn6029 and tn6026 are examples of composite transposons that have become widely disseminated on small and large plasmids with different incompatibility markers in pathogenic and commensal escherichia coli and various serovars of salmonella enterica. some of the plasmids that harbour these transposons also carry combinations of virulence genes. recently, tn6029 and tn6026 an ... | 2015 | 25917547 |
| h-ns silencing of the salmonella pathogenicity island 6-encoded type vi secretion system limits salmonella enterica serovar typhimurium interbacterial killing. | the secretion of bacterial toxin proteins is achieved by dedicated machineries called secretion systems. the type vi secretion system (t6ss) is a widespread versatile machine used for the delivery of protein toxins to both prokaryotic and eukaryotic cells. in salmonella enterica serovar typhimurium, the expression of the t6ss genes is activated during macrophage or mouse infection. here, we show that the t6ss gene cluster is silenced by the histone-like nucleoid structuring h-ns protein using a ... | 2015 | 25916986 |
| tracking the elusive function of bacillus subtilis hfq. | rna-binding protein hfq is a key component of the adaptive responses of many proteobacterial species including escherichia coli, salmonella enterica and vibrio cholera. in these organisms, the importance of hfq largely stems from its participation to regulatory mechanisms involving small non-coding rnas. in contrast, the function of hfq in gram-positive bacteria has remained elusive and somewhat controversial. in the present study, we have further addressed this point by comparing growth phenoty ... | 2015 | 25915524 |
| unprecedented mechanism employed by the salmonella enterica eutt atp:co(i)rrinoid adenosyltransferase precludes adenosylation of incomplete co(ii)rrinoids. | three distinct families of atp:corrinoid adenosyltransferases (acats) exist that are capable of converting vitamin b12 derivatives into coenzyme b12 by catalyzing the thermodynamically challenging reduction of co(ii) rrinoids to form "supernucleophilic" co(i) intermediates. while the structures and mechanisms of two of the acat families have been studied extensively, little is known about the eutt enzymes beyond the fact that they exhibit a unique requirement for a divalent metal cofactor for en ... | 2015 | 25914129 |
| pseudogenization of sopa and sope2 is functionally linked and contributes to virulence of salmonella enterica serovar typhi. | the difference in host range between salmonella enterica serovar typhimurium (s. typhimurium) and s. enterica serovar typhi (s. typhi) can be partially attributed to pseudogenes. pseudogenes are genomic segments homologous to functional genes that do not encode functional products due to the presence of genetic defects. s. typhi lacks several protein effectors implicated in invasion or other important processes necessary for full virulence of s. typhimurium. sopa and sope2, effectors that have b ... | 2015 | 25913156 |
| acid environments affect biofilm formation and gene expression in isolates of salmonella enterica typhimurium dt104. | the aim of this study was to examine the survival and potential virulence of biofilm-forming salmonella typhimurium dt104 under mild acid conditions. salmonella typhimurium dt104 employs an acid tolerance response (atr) allowing it to adapt to acidic environments. the threat that these acid adapted cells pose to food safety could be enhanced if they also produce biofilms in acidic conditions. the cells were acid-adapted by culturing them in 1% glucose and their ability to form biofilms on stainl ... | 2015 | 25912312 |
| distribution and characterization of salmonella enterica isolates from irrigation ponds in the southeastern united states. | irrigation water has been implicated as a likely source of produce contamination by salmonella enterica. therefore, the distribution of s. enterica was surveyed monthly in irrigation ponds (n = 10) located within a prime agricultural region in southern georgia and northern florida. all ponds and 28.2% of all samples (n = 635) were positive for salmonella, with an overall geometric mean concentration (0.26 most probable number [mpn]/liter) that was relatively low compared to prior reports for riv ... | 2015 | 25911476 |
| combining lactic acid spray with near-infrared radiation heating to inactivate salmonella enterica serovar enteritidis on almond and pine nut kernels. | the aim of this study was to investigate the efficacy of near-infrared radiation (nir) heating combined with lactic acid (la) sprays for inactivating salmonella enterica serovar enteritidis on almond and pine nut kernels and to elucidate the mechanisms of the lethal effect of the nir-la combined treatment. also, the effect of the combination treatment on product quality was determined. separately prepared s. enteritidis phage type (pt) 30 and non-pt 30 s. enteritidis cocktails were inoculated on ... | 2015 | 25911473 |
| the development and evaluation of a loop-mediated isothermal amplification method for the rapid detection of salmonella enterica serovar typhi. | typhoid fever remains a public health threat in many countries. a positive result in traditional culture is a gold-standard for typhoid diagnosis, but this method is time consuming and not sensitive enough for detection of samples containing a low copy number of the target organism. the availability of the loop-mediated isothermal amplification (lamp) assay, which offers high speed and simplicity in detection of specific targets, has vastly improved the diagnosis of numerous infectious diseases. ... | 2015 | 25910059 |
| ultrasensitive detection and rapid identification of multiple foodborne pathogens with the naked eyes. | in this study, a novel approach for ultrasensitive detection and rapid high-throughput identification of a panel of common foodborne pathogens with the naked eyes is presented. as a proof-of-concept application, a multiple pathogen analysis array is fabricated through immobilizing three specific polyt-capture probes which can respectively recognize rfbe gene (escherichia coli o157:h7), inva gene (salmonella enterica), inla gene (listeria monocytogenes) on the plastic substrates. pcr has been dev ... | 2015 | 25909338 |
| effects of listeria monocytogenes egd-e and salmonella enterica ser. typhimurium lt2 chitinases on intracellular survival in dictyostelium discoideum and mammalian cell lines. | some bacterial pathogens produce chitinases as virulence factors during host infection. the molecular target of such enzymes in non-chitinous hosts remains uncertain. we studied the importance of listeria monocytogenes egd-e and salmonella enterica ser. typhimurium lt2 chitinases for intracellular survival in dictyostelium discoideum, and for salmonella, also infection of mammalian cell lines, and a mouse model. the salmonella chitinase did not contribute significantly to infection of d. discoid ... | 2015 | 25908871 |
| mangrovibacter yixingensis sp. nov., isolated from farmland soil. | a gram-staining-negative, facultatively anaerobic, rod-shaped, nitrogen-fixing bacterial strain, designated tull-at, was isolated from a farmland soil sample in yixing, china. the optimal conditions for growth were 30 °c, ph 7.0-8.0 and 0% (w/v) nacl. q8 was the dominant respiratory quinone and the major polar lipids were phosphatidylethanolamine, phosphatidylglycerol and aminophospholipid. phylogenetic analysis of 16s rrna gene sequences showed that strain tull-at was most closely related to ma ... | 2015 | 25908712 |
| a survey of zoonotic pathogens carried by non-indigenous rodents at the interface of the wet tropics of north queensland, australia. | in 1964, brucella was isolated from rodents trapped in wooroonooran national park (wnp), in northern queensland, australia. genotyping of bacterial isolates in 2008 determined that they were a novel brucella species. this study attempted to reisolate this species of brucella from rodents living in the boundary area adjacent to wnp and to establish which endo- and ecto-parasites and bacterial agents were being carried by non-indigenous rodents at this interface. seventy non-indigenous rodents wer ... | 2017 | 25906923 |
| live attenuated vaccines for invasive salmonella infections. | salmonella enterica serovar typhi produces significant morbidity and mortality worldwide despite the fact that there are licensed salmonella typhi vaccines available. this is primarily due to the fact that these vaccines are not used in the countries that most need them. there is growing recognition that an effective invasive salmonella vaccine formulation must also prevent infection due to other salmonella serovars. we anticipate that a multivalent vaccine that targets the following serovars wi ... | 2015 | 25902362 |
| salmonella enterica serovar weltevreden st1500 associated foodborne outbreak in pune, india. | 2015 | 25900961 | |
| a single amino acid of a salmonella virulence protein contributes to pathogenicity by protecting from the ftsh-mediated proteolysis. | ftsh is a membrane-bound atp-dependent protease in bacteria that is critical for degrading membrane proteins. the mgtc virulence protein from salmonella enterica is located at the inner membrane and required for survival inside macrophages. here we report that a single substitution at tryptophan 226 of the mgtc protein to alanine promotes the ftsh-mediated proteolysis. the trp residue is located at the very c-terminus of the cytoplasmic domain of the mgtc protein and conserved only in intracellu ... | 2015 | 25900124 |
| colorimetric biosensing of targeted gene sequence using dual nanoparticle platforms. | we have developed a colorimetric biosensor using a dual platform of gold nanoparticles and graphene oxide sheets for the detection of salmonella enterica. the presence of the inva gene in s. enterica causes a change in color of the biosensor from its original pinkish-red to a light purplish solution. this occurs through the aggregation of the primary gold nanoparticles-conjugated dna probe onto the surface of the secondary graphene oxide-conjugated dna probe through dna hybridization with the ta ... | 2015 | 25897217 |
| replication of salmonella enterica serovar typhimurium in human monocyte-derived macrophages. | salmonella enterica serovar typhimurium is a common cause of food-borne gastrointestinal illness, but additionally it causes potentially fatal bacteremia in some immunocompromised patients. in mice, systemic spread and replication of the bacteria depend upon infection of and replication within macrophages, but replication in human macrophages is not widely reported or well studied. in order to assess the ability of salmonella typhimurium to replicate in human macrophages, we infected primary mon ... | 2015 | 25895967 |
| description of a putative oligosaccharyl:s-layer protein transferase from the tyrosine o-glycosylation system of paenibacillus alvei ccm 2051(t). | surface (s)-layer proteins are model systems for studying protein glycosylation in bacteria and simultaneously hold promises for the design of novel, glyco-functionalized modules for nanobiotechnology due to their 2d self-assembly capability. understanding the mechanism governing s-layer glycan biosynthesis in the gram-positive bacterium paenibacillus alvei ccm 2051(t) is necessary for the tailored glyco-functionalization of its s-layer. here, the putative oligosaccharyl:s-layer protein transfer ... | 2012 | 25893145 |
| isolation of salmonella from ready-to-eat poultry meat and evaluation of its survival at low temperature, microwaving and simulated gastric fluids. | a study was conducted to evaluate the risk of salmonella contamination and its survival at different stages in chill ready-to-eat poultry meat products chain. samples (n = 181) were collected and examined for the presence of salmonella species. the bacteria were initially identified against polyvalent antisera "o" and "h", followed by confirmation with 16 s rdna. the single salmonella, isolate from the tested food samples showed 99.8 % phylogenetic similarity with salmonella enterica. it was fur ... | 2015 | 25892808 |
| molecular survey of occurrence and quantity of legionella spp., mycobacterium spp., pseudomonas aeruginosa and amoeba hosts in municipal drinking water storage tank sediments. | to examine the occurrence and quantity of potential pathogens and an indicator of microbial contamination in the sediments of municipal drinking water storage tanks (mdwsts), given the absence of such data across the united states. | 2015 | 25891145 |
| evaluation of tubex-tf and onsite typhoid igg/igm combo rapid tests to detect salmonella enterica serovar typhi infection during a typhoid outbreak in harare, zimbabwe. | salmonella enterica serovar typhi, the causative agent of typhoid, is endemic in most parts of the world especially in africa. reliable and rapid diagnosis of the bacterium is therefore critical for confirmation of all suspected typhoid cases. in many parts of zimbabwe, laboratory capacity to isolate the microorganism by culture method as a way of diagnosis has limitations. in this study, two rapid serological kits, tubex-tf and onsite typhoid igg/igm combo, were evaluated for possible expeditio ... | 2015 | 25890321 |
| improved cell surface display of salmonella enterica serovar enteritidis antigens in escherichia coli. | salmonella enterica serovar enteritidis (se) is one of the most potent pathogenic salmonella serotypes causing food-borne diseases in humans. we have previously reported the use of the β-autotransporter aida-i to express the salmonella flagellar protein h:gm and the se serotype-specific fimbrial protein sefa at the surface of e. coli as live bacterial vaccine vehicles. while sefa was successfully displayed at the cell surface, virtually no full-length h:gm was exposed to the medium due to extens ... | 2015 | 25889453 |
| conjunctival flora of clinically normal and diseased turtles and tortoises. | in captive breed turtles and tortoises conjunctival disease is common. our aim was to investigate the bacterial and fungal flora present in the eyes of healthy and pathological chelonians and to compare findings in turtles with those in tortoises. | 2015 | 25889261 |
| novel pegylated silver coated carbon nanotubes kill salmonella but they are non-toxic to eukaryotic cells. | resistance of food borne pathogens such as salmonella to existing antibiotics is of grave concern. silver coated single walled carbon nanotubes (swcnts-ag) have broad-spectrum antibacterial activity and may be a good treatment alternative. however, toxicity to human cells due to their physico-chemical properties is a serious public health concern. although pegylation is commonly used to reduce metal nanoparticle toxicity, swcnts-ag have not been pegylated as yet, and the effect of pegylation of ... | 2015 | 25888864 |
| presence of zoonotic agents in engorged ticks and hedgehog faeces from erinaceus europaeus in (sub) urban areas. | european hedgehogs (erinaceus europaeus) are hosts for ixodes hexagonus and i. ricinus ticks, which are vectors for zoonotic microorganisms. in addition, hedgehogs may carry several enteric zoonoses as well. it is unclear to what extent a presence of pathogens in hedgehogs poses a risk to public health, as information on the presence of zoonotic agents in hedgehogs in urban areas is relatively scarce. | 2015 | 25885888 |
| two draft genome sequences of a new serovar of salmonella enterica, serovar lubbock. | salmonella enterica is principally a foodborne pathogen that shows considerable serovar diversity. in this report, we present two draft genome sequences of salmonella enterica subsp. enterica serovar lubbock, a novel serovar. | 2015 | 25883279 |
| first description of food-borne salmonella enterica resistance regions r1 and r3 associated with is26 elements. | in this study, we assessed the presence of is26 in food-borne assut-type salmonella enterica isolates. a new genetic region (r3) was described, that included a c14 caspase gene between is26 elements. r3 was present in two salmonella rissen isolates from a swine carcass and a meat handler, collected at the same abattoir. furthermore, a new rearrangement of resistance region r1, harboring the blatem-1 gene flanked by is26 elements, was identified in salmonella typhimurium and salmonella 4,[5],12:i ... | 2015 | 25881795 |
| ongoing outbreak of salmonella enterica serovar paratyphi a infections, phnom penh, cambodia. | 2015 | 25881538 | |
| use of ensure® nutrition shakes as an alternative formulation method for live recombinant attenuated salmonella typhi vaccines. | to be effective, orally administered live salmonella vaccines must first survive their encounter with the low ph environment of the stomach. to enhance survival, an antacid is often given to neutralize the acidic environment of the stomach just prior to or concomitant with administration of the vaccine. one drawback of this approach, from the perspective of the clinical trial volunteer, is that the taste of a bicarbonate-based acid neutralization system can be unpleasant. thus, we explored an al ... | 2015 | 25879849 |
| [salmonella spp. prevalence and contamination risk factors in broiler and broiler meat of gallus gallus in germany and the european union]. | in order to reduce the prevalence of the salmonella enterica serovars typhimurium and enteritidis as a main causative agent of human salmonellosis originating from poultry flocks and products, the eu regulations 2160/2003 and 2073/2005 and the german hühner-salmonellen-verordnung were established ten years ago. a literature review shows that this aim could be reached to a large extend in many areas of the food production chain, e.g. in breeding and husbandry facilities in most eu member states i ... | 2015 | 25876278 |
| draft genome sequence of multidrug resistant salmonella enterica serovar weltevreden isolated from seafood. | salmonella enterica subsp. enterica serovar weltevereden is the most frequent serovar isolated from asia. here, we report a draft genome sequence of multidrug resistant salmonella weltevreden 9 isolated from seafood. whole-genome of this isolate and annotation will help enhance the understanding of this pathogenic multidrug-resistant serovar. | 2015 | 25874015 |
| efficiency of conditionally attenuated salmonella enterica serovar typhimurium in bacterium-mediated tumor therapy. | increasing numbers of cancer cases generate a great urge for new treatment options. applying bacteria like salmonella enterica serovar typhimurium for cancer therapy represents an intensively explored option. these bacteria have been shown not only to colonize solid tumors but also to exhibit an intrinsic antitumor effect. in addition, they could serve as tumor-targeting vectors for therapeutic molecules. however, the pathogenic s. typhimurium strains used for tumor therapy need to be attenuated ... | 2015 | 25873375 |
| immunization with ty21a live oral typhoid vaccine elicits crossreactive multifunctional cd8+ t-cell responses against salmonella enterica serovar typhi, s. paratyphi a, and s. paratyphi b in humans. | previously we have extensively characterized salmonella enterica serovar typhi (s. typhi)-specific cell-mediated immune (cmi) responses in volunteers orally immunized with the licensed ty21a typhoid vaccine. in this study we measured salmonella-specific multifunctional (mf) cd8+ t-cell responses to further investigate whether ty21a elicits crossreactive cmi against s. paratyphi a and s. paratyphi b that also cause enteric fever. ty21a-elicited crossreactive cmi responses against all three salmon ... | 2015 | 25872480 |
| [increase in antimicrobial resistance of salmonella from food to fluoroquinolones and cephalosporins--a review of data from ten years]. | animal derived food is a relevant source of human infections with salmonella enterica. in this paper we analyse the presence of salmonella in meat with respect to the observed serovars and their resistance to the fluoroquinolone ciprofloxacin and 3rd generation cephalosporins in the years 2003 to 2012. data originated from 8176 isolates that were isolated from meat, characterized in the national reference laboratory for salmonella and tested for antimicrobial resistance in the national reference ... | 2015 | 25872252 |
| multiresistance to antibiotics of salmonella enterica serovar typhimurium strains producing extended spectrum beta-lactamases (esbls). | the purpose of the study is to give the rising incidence of salmonellosis and the continuous decrease of sensitivity of salmonella to a range of antibiotics, the prime importance of the choice of optimal anti-infective chemotherapy in order to prevent the selection of multidrug-resistant strains (mdr). we have studied 54 strains of salmonella sent for further investigation to "cantacuzino" nirdmi bucharest. the statistical analysis was based on the interpretation pathogen susceptibility and anal ... | 2014 | 25870680 |
| development and validation of a high-throughput cell-based screen to identify activators of a bacterial two-component signal transduction system. | cpxra is a two-component signal transduction system (2csts) found in many drug-resistant gram-negative bacteria. in response to periplasmic stress, cpxa autophosphorylates and donates a phosphoryl group to its cognate response regulator, cpxr. phosphorylated cpxr (cpxr-p) upregulates genes involved in membrane repair and downregulates multiple genes that encode virulence factors, which are trafficked across the cell membrane. mutants that constitutively activate cpxra in salmonella enterica sero ... | 2015 | 25870061 |
| anti-salmonella activity of volatile compounds of vietnam coriander. | essential oil derived from the fresh leaves of polygonum odoratum lour was tested for their effects on a foodborne bacterium salmonella choleraesuis subsp. choleraesuis atcc 35640 using a broth dilution method. this essential oil showed a significant antibacterial activity against s. choleraesuis at the concentration of 200 µg/ml. twenty-five volatile compounds were characterized from this essential oil by gc-ms, and aldehyde compounds were found abundant and accounted for more than three-fourth ... | 2015 | 25870012 |
| molecular characterization of salmonella enterica isolates associated with starling-livestock interactions. | bird-livestock interactions have been implicated as potential sources for bacteria within concentrated animal feeding operations (cafo). in this study we characterized xbai-digested genomic dna from salmonella enterica using pulsed-field gel electrophoresis (pfge). the pfge analysis was conducted using 182 s. enterica isolates collected from a single cafo between 2009 and 2012. samples collected in 2012 were subjected to antimicrobial susceptibility testing. the analysis was limited to s. enteri ... | 2015 | 25866128 |
| removal of pathogenic bacterial biofilms by combinations of oxidizing compounds. | bacterial biofilms are commonly formed on medical devices and food processing surfaces. the antimicrobials used have limited efficacy against the biofilms; therefore, new strategies to prevent and remove these structures are needed. here, the effectiveness of brief oxidative treatments, based on the combination of sodium hypochlorite (naclo) and hydrogen peroxide (h2o2) in the presence of copper sulfate (cuso4), were evaluated against bacterial laboratory strains and clinical isolates, both in p ... | 2015 | 25864510 |
| rapid detection of listeria monocytogenes in milk using confocal micro-raman spectroscopy and chemometric analysis. | listeria monocytogenes is a facultatively anaerobic, gram-positive, rod-shape foodborne bacterium causing invasive infection, listeriosis, in susceptible populations. rapid and high-throughput detection of this pathogen in dairy products is critical as milk and other dairy products have been implicated as food vehicles in several outbreaks. here we evaluated confocal micro-raman spectroscopy (785 nm laser) coupled with chemometric analysis to distinguish six closely related listeria species, inc ... | 2015 | 25863337 |
| purification and characterization of a novel plantaricin, kl-1y, from lactobacillus plantarum kl-1. | three bacteriocins from lactobacillus plantarum kl-1 were successfully purified using ammonium sulfate precipitation, cation-exchange chromatography and reverse-phase hplc. the bacteriocin peptides kl-1x, -1y and -1z had molecular masses of 3053.82, 3498.16 and 3533.16 da, respectively. all three peptides were stable at ph 2-12 and 25 °c and at high temperatures of 80 and 100 °c for 30 min and 121 °c for 15 min. however, they differed in their susceptibility to proteolytic enzymes and their inhi ... | 2015 | 25862353 |
| pulsed-field gel electrophoresis of salmonella enterica. | pulsed-field gel electrophoresis (pfge) is considered a "gold standard" for the molecular characterization of a number of bacterial strains. its strength relies on its high discriminatory power, together with its high reproducibility. for many years, an international network, pulsenet international, allows the rapid comparison of pfge data obtained all over the world, and it provides a valuable tool to promptly recognize the epidemiological dynamics of many pathogens, including salmonella enteri ... | 2015 | 25862058 |
| expression and function of s100a8/a9 (calprotectin) in human typhoid fever and the murine salmonella model. | typhoid fever, caused by the gram-negative bacterium salmonella enterica serovar typhi, is a major cause of community-acquired bacteremia and death worldwide. s100a8 (mrp8) and s100a9 (mrp14) form bioactive antimicrobial heterodimers (calprotectin) that can activate toll-like receptor 4, promoting lethal, endotoxin-induced shock and multi-organ failure. we aimed to characterize the expression and function of s100a8/a9 in patients with typhoid fever and in a murine invasive salmonella model. | 2015 | 25860480 |
| genome-wide methylation patterns in salmonella enterica subsp. enterica serovars. | the methylation of dna bases plays an important role in numerous biological processes including development, gene expression, and dna replication. salmonella is an important foodborne pathogen, and methylation in salmonella is implicated in virulence. using single molecule real-time (smrt) dna-sequencing, we sequenced and assembled the complete genomes of eleven salmonella enterica isolates from nine different serovars, and analysed the whole-genome methylation patterns of each genome. we descri ... | 2015 | 25860355 |
| acute scrotal ulcers in typhoid fever: case report and literature review. | in developed countries, typhoid fever is a travel-associated disease that is often overlooked. however, as standard blood and stool culture methods have relatively low sensitivity, diagnosis depends heavily on clinical signs and symptoms and on a high level of suspicion. | 2015 | 25859155 |
| the role of carbohydrates in infection strategies of enteric pathogens. | enteric pathogens cause considerable public health concerns worldwide including tropical regions. here, we review the roles of carbohydrates in the infection strategies of various enteric pathogens including viruses, bacteria and protozoa, which infect the epithelial lining of the human and animal intestine. at host cell entry, enteric viruses, including norovirus, recognize mainly histo-blood group antigens. at the initial step of bacterial infections, carbohydrates also function as receptors f ... | 2015 | 25859152 |
| complete genome sequence of salmonella enterica serovar typhimurium myophage mushroom. | salmonella enterica serovar typhimurium (s. typhimurium) is a leading cause of foodborne illness worldwide. over the past two decades, strains resistant to antibiotics have begun to emerge, highlighting the need for alternative treatment strategies such as bacteriophage therapy. here, we present the complete genome of mushroom, an s. typhimurium myophage. | 2015 | 25858827 |
| multiplexed detection of foodborne pathogens based on magnetic particles. | this paper addresses the novel approaches for the multiplex detection of food poisoning bacteria, paying closer attention to three of the most common pathogens involved in food outbreaks: salmonella enterica, escherichia coli o157:h7 and listeria monocytogenes. end-point and real-time pcr, classical immunological techniques, biosensors, microarrays and microfluidic platforms, as well as commercial kits for multiplex detection of food pathogens will be reviewed, with special focus on the role of ... | 2015 | 25858812 |
| antibiotic-resistant bacteria: prevalence in food and inactivation by food-compatible compounds and plant extracts. | foodborne antibiotic-resistant pathogenic bacteria such as campylobacter jejuni, bacillus cereus, clostridium perfringens, escherichia coli, salmonella enterica, staphylococcus aureus, vibrio cholerae, and vibrio parahemolyticus can adversely affect animal and human health, but a better understanding of the factors involved in their pathogenesis is needed. to help meet this need, this overview surveys and interprets much of our current knowledge of antibiotic (multidrug)-resistant bacteria in th ... | 2015 | 25856120 |
| murine gammaherpesvirus 68 pathogenesis is independent of caspase-1 and caspase-11 in mice and impairs interleukin-1β production upon extrinsic stimulation in culture. | gammaherpesviruses establish lifelong infections that are associated with the development of cancer. these viruses subvert many aspects of the innate and adaptive immune response of the host. the inflammasome, a macromolecular protein complex that controls inflammatory responses to intracellular danger signals generated by pathogens, is both activated and subverted during human gammaherpesvirus infection in culture. the impact of the inflammasome response on gammaherpesvirus replication and late ... | 2015 | 25855746 |
| typhoid fever in young children in bangladesh: clinical findings, antibiotic susceptibility pattern and immune responses. | children bear a large burden of typhoid fever caused by salmonella enterica serotype typhi (s. typhi) in endemic areas. however, immune responses and clinical findings in children are not well defined. here, we describe clinical and immunological characteristics of young children with s. typhi bacteremia, and antimicrobial susceptibility patterns of isolated strains. | 2015 | 25849611 |