Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| is occult hepatitis b virus infection with detectable anti-hbs infectious or not? | 2016 | 27252823 | |
| inverse association of plasma level of glutathione peroxidase with liver fibrosis in chronic hepatitis b: potential role of iron. | background oxidative stress has a major pathogenic role for liver damage following chronic hepatitis b. glutathione peroxidase (gpx) is necessary in oxidative state mechanism that is generally down-regulated by hepatitis b virus (hbv) infection. on the other hand, disorders of iron homeostasis have been found out in hbv infected patients. therefore, the objective of this study was to assess the interplay of gpx and serum iron on clinical and virological features of patients with chronic hbv infe ... | 2016 | 27252819 |
| single-molecule sequencing reveals complex genome variation of hepatitis b virus during 15 years of chronic infection following liver transplantation. | chronic hepatitis b (chb) is prevalent worldwide. the infectious agent, hepatitis b virus (hbv), replicates via an rna intermediate and is error prone, leading to the rapid generation of closely related but not identical viral variants, including those that can escape host immune responses and antiviral treatments. the complexity of chb can be further enhanced by the presence of hbv variants with large deletions in the genome generated via splicing (sphbv variants). although sphbv variants are i ... | 2016 | 27252524 |
| short-term treatment outcomes in human immunodeficiency virus type-1 and hepatitis b virus co-infections. | co-infection of hiv with hbv is common in west africa but little information is available on the effects of hbv on short-term therapy for hiv patients. a 28 day longitudinal study was conducted to examine short-term antiretroviral therapy (art) outcomes in hiv infected individuals with hbv co-infection. | 2016 | 27251610 |
| reciprocal regulation of farnesoid x receptor α activity and hepatitis b virus replication in differentiated heparg cells and primary human hepatocytes. | hepatitis b virus (hbv) and bile salt metabolism seem tightly connected. hbv enters hepatocytes by binding to sodium taurocholate cotransporting polypeptide (ntcp), the genome of which contains 2 active farnesoid x receptor (fxr) α response elements that participate in hbv transcriptional activity. we investigated in differentiated heparg cells and in primary human hepatocytes (phhs) effects of fxr activation on hbv replication and of infection on the fxr pathway. in heparg cells, fxr agonists ( ... | 2016 | 27251172 |
| a 13-year retrospective study on primary liver cancer in cambodia: a strikingly high hepatitis c occurrence among hepatocellular carcinoma cases. | hepatocellular carcinoma (hcc) is the main type of primary liver cancer (plc) worldwide, but cholangiocarcinoma (cca) may be predominant in some specific regions of southeast asia. the aim of the present study was to delineate a pattern of cambodian plc patients attending the calmette hospital in the cambodian capital phnom penh. | 2016 | 27250992 |
| hepatitis b, c, and d virus infection showing distinct patterns between injection drug users and the general population. | hepatitis b, c, and d virus (hbv, hcv, and hdv) infections are known to be prevalent in injection drug users (idus); however, the relationship between the molecular epidemiologic features of hepatitis virus infection in high-risk individuals and the general population has not yet been established. | 2017 | 27248508 |
| comparison of genome-scale dna methylation profiles in hepatocellular carcinoma by viral status. | hepatocellular carcinoma (hcc) incidence has steadily increased in the us over the past 30 years. our understanding of epigenetic regulation in hcc is still limited, especially the impact of hepatitis b virus (hbv) or hepatitis c virus (hcv) infection on aberrant dna methylation. we performed genome-wide dna methylation profiling in 33 fresh frozen tumor samples, including 10 hbv-hcc, 13 hcv-hcc, and 10 non-infected (niv-hcc) using the illumina humanmethylation450 beadchip. gene expression profi ... | 2016 | 27248055 |
| pathologic femoral neck fracture due to fanconi syndrome induced by adefovir dipivoxil therapy for hepatitis b. | in fanconi syndrome, hypophosphatemic osteomalacia is caused by proximal renal tubule dysfunction which leads to impaired reabsorption of amino acids, glucose, urate, and phosphate. we present a rare case of a 43-year-old korean male who was found to have insufficiency stress fracture of the femoral neck secondary to osteomalacia due to fanconi syndrome. he had been receiving low-dose adefovir dipivoxil (adv, 10 mg/day) for the treatment of chronic hepatitis b virus infection for 7 years and he ... | 2016 | 27247753 |
| nomogram for hepatic steatosis: a simple and economical diagnostic tool for massive screening. | to establish a simple economical diagnostic tool for prediction of hepatic steatosis in patients with hepatitis b virus (hbv) infection. | 2016 | 27246795 |
| hepatitis b reactivation after ifosfamide therapy for retroperitoneal sarcoma. | patients receiving cancer treatment are at risk for hepatitis b virus (hbv) reactivation. ifosfamide is an alkylating agent and is considered to be one of the important drugs for the treatment of metastatic sarcoma. no association of ifosfamide and hbv reactivation has been reported so far. | 2016 | 27246626 |
| extremely elevated alpha-fetoprotein due to acute exacerbation of chronic hepatitis b without malignancy: a case report. | alpha-fetoprotein is produced by a variety of tumors such as hepatocellular carcinoma, hepatoblastoma, and germ cell tumors of the ovary and testes. however, we present a case of significantly elevated serum alpha-fetoprotein without evidence of malignant disease in a patient who is a carrier of chronic hepatitis b. | 2016 | 27246404 |
| evidence-based clinical practice guidelines for liver cirrhosis 2015. | the japanese society of gastroenterology revised the evidence-based clinical practice guidelines for liver cirrhosis in 2015. eighty-three clinical questions were selected, and a literature search was performed for the clinical questions with use of the medline, cochrane, and igaku chuo zasshi databases for the period between 1983 and june 2012. manual searching of the latest important literature was added until august 2015. the guidelines were developed with use of the grading of recommendation ... | 2016 | 27246107 |
| hepatitis b infection in hiv-1-infected patients receiving highly active antiretroviral therapy in lomé, togo: prevalence and molecular consequences. | no data are available on hiv/hepatitis b virus (hbv) or hepatitis c virus coinfection in togo, and patients are not routinely tested for hbv infection. | 2016 | 27245734 |
| serum hepatitis b virus rna is encapsidated pregenome rna that may be associated with persistence of viral infection and rebound. | hepatitis b virus (hbv) rna in serum has recently been linked to efficacy and prognosis of chronic hepatitis b (chb) treatment. this study explored the nature, origin, underlying mechanisms, and potential clinical significance of serum hbv rna. | 2016 | 27245431 |
| evidence of susceptibility to lamivudine-based haart and genetic stability of hepatitis b virus (hbv) in hiv co-infected patients: a south african longitudinal hbv whole genome study. | reports on the concomitant impact of hiv co-infection and long term highly active anti-retroviral therapy (haart) on the genetic stability and molecular evolution of hbv are limited in sub-saharan africa. | 2016 | 27245151 |
| association of il-10 polymorphisms with hepatitis b virus infection and outcome in han population. | this study evaluated the correlation of single nucleotide polymorphisms interleukin (il)-10-592 and -1082 with hepatitis b virus (hbv) susceptibility and recovery. | 2016 | 27245049 |
| high rate of hepatitis b virus mother-to-child transmission in lao people's democratic republic. | hepatitis b virus infection is endemic in lao people's democratic republic (pdr). among 3,000 pregnant women attending an antenatal clinic at mother and child hospital in vientiane, lao pdr, 5.8% were hbsag positive by a rapid test. among serum samples of 47 infants aged 9-12 months born to hbsag-positive mothers, 38% were anti-hbs negative. percent anti-hbs negative children is significantly higher in those born to hbeag positive mothers than in those born to hbeag negative mothers (60% vs 25%, ... | 2016 | 27244958 |
| genome-wide association study identifies 8p21.3 associated with persistent hepatitis b virus infection among chinese. | hepatitis b virus (hbv) infection is a common infectious disease. here we perform a genome-wide association study (gwas) among chinese populations to identify novel genetic loci involved in persistent hbv infection. gwas scan is performed in 1,251 persistently hbv infected subjects (pis, cases) and 1,057 spontaneously recovered subjects (srs, controls), followed by replications in four independent populations totally consisting of 3,905 pis and 3,356 srs. we identify a novel locus at 8p21.3 (ind ... | 2016 | 27244555 |
| international trends in liver cancer incidence, overall and by histologic subtype, 1978-2007. | primary liver cancer, the most common histologic types of which are hepatocellular carcinoma (hcc) and intrahepatic cholangiocarcinoma (icc), is the second leading cause of cancer death worldwide. while rising incidence of liver cancer in low-risk areas and decreasing incidence in some high-risk areas has been reported, trends have not been thoroughly explored by country or by histologic type. we examined liver cancer incidence overall and by histology by calendar time and birth cohort for selec ... | 2016 | 27244487 |
| clinical relevance of hla gene variants in hbv infection. | host gene variants may influence the natural history of hepatitis b virus (hbv) infection. the human leukocyte antigen (hla) system, the major histocompatibility complex (mhc) in humans, is one of the most important host factors that are correlated with the clinical course of hbv infection. genome-wide association studies (gwass) have shown that single nucleotide polymorphisms (snps) near certain hla gene loci are strongly associated with not only persistent hbv infection but also spontaneous hb ... | 2016 | 27243039 |
| links between human line-1 retrotransposons and hepatitis virus-related hepatocellular carcinoma. | hepatocellular carcinoma (hcc) accounts for approximately 80% of liver cancers, the third most frequent cause of cancer mortality. the most prevalent risk factors for hcc are infections by hepatitis b or hepatitis c virus. findings suggest that hepatitis virus-related hcc might be a cancer in which line-1 retrotransposon, often termed l1, activity plays a potential role. firstly, hepatitis viruses can suppress host defense factors that also control l1 mobilization. secondly, many recent studies ... | 2016 | 27242996 |
| improvement of in vivo antimicrobial activity of hbcard peptides by d-arginine replacement. | we previously identified a novel antimicrobial peptide with a broad spectrum bactericidal activity from human hepatitis b virus (hbv) core protein (hbc) arginine-rich domain (ard). we compared the antimicrobial activities of hbcard peptides from different hepadnaviruses which share similar amino acid sequences. in general, mammalian hbcard peptides exhibited stronger antimicrobial activity than avian peptides. using the strategy of d-amino acid substitutions, we improved the antimicrobial effica ... | 2016 | 27241023 |
| detection of hepatitis b virus dna in the blood of a stem cell donor after granulocyte colony-stimulating factor treatment. | 2016 | 27240006 | |
| vaccine wastage assessment after introduction of open vial policy in surat municipal corporation area of india. | as per the vaccine management policy of the government of india all vaccine vials opened for an immunization session were discarded at the end of that session, irrespective of the type of vaccine or the number of doses remaining in the vial prior to 2013. subsequently, open vial policy (ovp) was introduced in 2013 and should reduce both vaccine wastage as well as governmental healthcare costs for immunization. this study evaluates the vaccine wastage after introduction of the ovp and its compari ... | 2015 | 27239864 |
| hepatitis b surface antigen clearance in inactive hepatitis b surface antigen carriers treated with peginterferon alfa-2a. | to examine the association between interferon (ifn) therapy and loss of hepatitis b surface antigen (hbsag) in inactive hbsag carriers. | 2016 | 27239256 |
| vaccinating adult patients with cirrhosis: trends over a decade in the united states. | introduction. the progression of chronic liver disease to cirrhosis involves both innate and adaptive immune system dysfunction resulting in increased risk of infectious complications. vaccinations against pneumococcus, hepatitis a virus (hav), and hepatitis b virus (hbv) are well tolerated and effective in disease prevention and reduction in morbidity and mortality. prior studies assessing vaccination rates in patients with cirrhosis have specific limitations and to date no study has provided a ... | 2016 | 27239192 |
| multiplex qpcr for serodetection and serotyping of hepatitis viruses: a brief review. | the present review describes the current status of multiplex quantitative real time polymerase chain reaction (qpcr) assays developed and used globally for detection and subtyping of hepatitis viruses in body fluids. several studies have reported the use of multiplex qpcr for the detection of hepatitis viruses, including hepatitis a virus (hav), hepatitis b virus (hbv), hepatitis c virus (hcv), hepatitis d virus (hdv), and hepatitis e virus (hev). in addition, multiplex qpcr has also been develo ... | 2016 | 27239109 |
| epcam-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis b virus-infected hepatocytes. | hepatocytes in which the hepatitis b virus (hbv) is replicating exhibit loss of the chromatin modifying polycomb repressive complex 2 (prc2), resulting in re-expression of specific, cellular prc2-repressed genes. epithelial cell adhesion molecule (epcam) is a prc2-repressed gene, normally expressed in hepatic progenitors, but re-expressed in hepatic cancer stem cells (hcscs). herein, we investigated the functional significance of epcam re-expression in hbv-mediated hepatocarcinogenesis. | 2016 | 27238755 |
| exosomes mediate hepatitis b virus (hbv) transmission and nk-cell dysfunction. | evidence suggests that exosomes can transfer genetic material between cells. however, their roles in hepatitis b virus (hbv) infection remain unclear. here, we report that exosomes present in the sera of chronic hepatitis b (chb) patients contained both hbv nucleic acids and hbv proteins, and transferred hbv to hepatocytes in an active manner. notably, hbv nucleic acids were detected in natural killer (nk) cells from both chb patients and healthy donors after exposure to hbv-positive exosomes. t ... | 2016 | 27238466 |
| redirecting t cell specificity using t cell receptor messenger rna electroporation. | autologous t lymphocytes genetically modified to express t cell receptors or chimeric antigen receptors have shown great promise in the treatment of several cancers, including melanoma and leukemia. in addition to tumor-associated antigens and tumor-specific neoantigens, tumors expressing viral peptides can also be recognized by specific t cells and are attractive targets for cell therapy. hepatocellular carcinoma cells often have hepatitis b virus dna integration and can be targeted by hepatiti ... | 2016 | 27236807 |
| association of hla-dq and ifnl4 polymorphisms with susceptibility to hepatitis b virus infection and clearance. | background and aim. leukocyte antigen dq (hla-dq) and interferon-λ4 (ifnl4) gene polymorphisms were associated with susceptibility to chronic hepatitis b and c virus infection. this study further confirmed that variants of these genes were associated with susceptibility and spontaneous clearance of hbv infection in a chinese population. | 2017 | 27236152 |
| meta-analysis of prophylactic entecavir or lamivudine against hepatitis b virus reactivation. | introduction and aim. studies suggest that entecavir and lamivudine are useful as prophylactics against hepatitis b virus (hbv) reactivation in patients undergoing chemotherapy or immunosuppressive therapy, but which drug is more effective is unclear. here we meta-analyzed available evidence on relative efficacy of prophylactic entecavir or lamivudine therapy in patients with chronic or resolved hepatitis b infection who were undergoing chemotherapy or immunosuppressive therapy. | 2017 | 27236149 |
| impact of adjuvants on cd4(+) t cell and b cell responses to a protein antigen vaccine: results from a phase ii, randomized, multicenter trial. | immunogenicity and safety of different adjuvants combined with a model antigen (hbsag) were compared. healthy hbv-naïve adults were randomized to receive hbs adjuvanted with alum or adjuvant systems as01b, as01e, as03a or as04 at days 0 and 30. different frequencies of hbs-specific cd4+ t cells 14days post dose 2 but similar polyfunctionality profiles were induced by the different adjuvants with frequencies significantly higher in the as01b and as01e groups than in the other groups. antibody con ... | 2016 | 27236001 |
| hepatitis b virus enhances cisplatin-induced hepatotoxicity via a mechanism involving suppression of glucose-regulated protein of 78 kda. | cisplatin is a classical platinum-based chemotherapeutic drug used in the treatment of many cancer types, including hepatocellular carcinoma (hcc). the application of cisplatin is significantly limited by its toxicity, which may be affected by various biological factors. persistence of hepatitis b virus (hbv) infection leads to hcc development and may be associated with higher incidence of severe hepatitis during chemotherapy. however, whether hbv alters the susceptibility of hepatocytes to cisp ... | 2016 | 27234046 |
| transmission of blood-borne pathogens in us dental health care settings: 2016 update. | during the past decade, investigators have reported transmissions of blood-borne pathogens (bbps) in dental settings. in this article, the authors describe these transmissions and examine the lapses in infection prevention on the basis of available information. | 2016 | 27233680 |
| sarcopenia and two types of presarcopenia in japanese patients with chronic liver disease. | the frequency of sarcopenia, defined as loss of both muscle volume and strength, was analyzed in chronic liver disease (cld). | 2016 | 27232361 |
| nomograms for survival prediction in patients undergoing liver resection for hepatitis b virus related early stage hepatocellular carcinoma. | the long-term outcomes of patients who underwent liver resection (lr) for early-stage hepatitis b virus (hbv)-related hepatocellular carcinomas (hccs) are difficult to predict. this study aimed to develop two nomograms to predict postoperative disease-free survival (dfs) and overall survival (os), respectively. | 2016 | 27232330 |
| restrictive influence of samhd1 on hepatitis b virus life cycle. | deoxynucleotide triphosphates (dntps) are essential for efficient hepatitis b virus (hbv) replication. here, we investigated the influence of the restriction factor samhd1, a dntp hydrolase (dntpase) and rnase, on hbv replication. we demonstrated that silencing of samhd1 in hepatic cells increased hbv replication, while overexpression had the opposite effect. samhd1 significantly affected the levels of extracellular viral dna as well as intracellular reverse transcription products, without affec ... | 2016 | 27229711 |
| [molecular biology of hepatitis b virus and immunopathogenesis of chronic viral hepatitis b]. | chronic hepatitis b belongs to a category of socially significant diseases due to its wide abundance in the world and high frequency of unfavourable outcomes of this disease. features of interaction of hepatitis b virus with human immune system, accompanying development of mechanisms of escape from immunological control, is the basis of development of chronic hepatitis b. molecular-biological features of hepatitis b virus are the basis of the indicated mechanisms, and the content of this review ... | 2016 | 27228681 |
| progressive accumulation of mutations in the hepatitis b virus genome and its impact on time to diagnosis of hepatocellular carcinoma. | to evaluate how hepatitis b virus (hbv) genetic variation affected progression from chronic carrier state to hepatocellular carcinoma (hcc), we analyzed hbv full-length sequences in blood obtained <1-20 years before diagnosis from 117 hcc cases and 118 controls nested in a cohort of 4,841 hbv carriers, for whom hbv genotypes b and c are predominant. the relationship between each viral single-nucleotide polymorphism (snp) and hcc development was assessed using ordinal logistic models according to ... | 2016 | 27228506 |
| pretransplant hepatitis b viral infection increases risk of death after kidney transplantation: a multicenter cohort study in korea. | clinical outcomes in kidney transplant recipients (ktrs) with hepatitis b virus (hbv) have not been thoroughly evaluated. here, we investigated recent posttransplant clinical outcomes of ktrs with hbv and compared them with ktrs with hepatitis c virus (hcv) and seronegative ktrs.of 3855 ktrs from april 1999 to december 2011, we enrolled 3482 ktrs who had viral hepatitis serology data; the patients were followed up for 89.1 ± 54.1 months. the numbers of recipients with hbv and hcv were 160 (4.6%) ... | 2016 | 27227927 |
| suppression of usp18 potentiates the anti-hbv activity of interferon alpha in hepg2.2.15 cells via jak/stat signaling. | ubiquitin-specific protease 18 (usp18, also known as ubp43) has both interferon stimulated gene 15 (isg15) dependent and isg15-independent functions. by silencing the expression of usp18 in hepg2.2.15 cells, we studied the effect of usp18 on the anti-hbv activity of ifn-f and demonstrated that knockdown of usp18 significantly inhibited the hbv expression and increased the expression of isgs. levels of hepatitis b virus surface antigen (hbsag), hepatitis b virus e antigen (hbeag), hbv dna and int ... | 2016 | 27227879 |
| the hbsag prevalence among blood donors from eastern mediterranean and middle eastern countries: a systematic review and meta-analysis. | the world health organization (who) recommends that all blood donations should be screened for evidence of infections, such as hepatitis b. the present study aimed to determine the prevalence of hepatitis b surface antigen (hbsag) in blood donors at the eastern mediterranean region office (emro) of the who and middle eastern countries. | 2016 | 27226804 |
| relative importance of hepatitis b and c viruses in hepatocellular carcinoma in emro countries and the middle east: a systematic review. | hepatocellular carcinoma (hcc) is the second most common cancer-related death worldwide. although many factors including dietary aflatoxin b1 (afb1) and alcoholic and non-alcoholic fatty liver diseases can lead to hcc, globally most hcc cases are due to hepatitis b virus (hbv) and hepatitis c virus (hcv). considering the importance of these viral factors in most hcc cases and relative lack of literature from eastern mediterranean region office of world health organization (emro) countries and th ... | 2016 | 27226803 |
| characterization of occult hepatitis b infection among injecting drug users in tehran, iran. | hepatitis b virus (hbv) infection is a major health problem worldwide. | 2016 | 27226802 |
| the correlation between interferon lambda 3 gene polymorphisms and susceptibility to hepatitis b virus infection. | cytokines are proteins that mediate innate and adaptive immunity responses. it is hypothesized that interferon lambda 3 (ifnl3) levels can influence the outcome of chronic hepatitis b virus (hbv) infection. polymorphisms in ifn genes have been associated with response to infection. | 2016 | 27226800 |
| the association of pre-s/s gene mutations and hepatitis b virus vertical transmission. | hbv pre-s/s gene mutations can occur before or after implementation of combined vaccination program. hbv prs-s/s gene mutation is a risk factor of vaccination failure and frequently causes hbv vertical transfection. | 2016 | 27226799 |
| the prevalence of hepatitis b virus among municipal solid waste workers: necessity for immunization of at-risk groups. | hepatitis b virus (hbv) is likely to be more prevalent in certain populations and occupational groups, such as municipal solid waste workers (mswws). | 2016 | 27226797 |
| characterization of the inflammasome in human kupffer cells in response to synthetic agonists and pathogens. | the liver is the largest gland in the human body and functions as an innate immune organ. liver macrophages called kupffer cells (kc) constitute the largest group of macrophages in the human body. innate immune responses involving kc represent the first line of defense against pathogens in the liver. human monocyte-derived macrophages have been used to characterize inflammasome responses that lead to the release of the proinflammatory cytokines il-1β and il-18, but it has not yet been determined ... | 2016 | 27226092 |
| [hepatitis b virus and chromatin remodeling: hbx counteracts setdb1/hp1/h3k9me3 transcriptional silencing]. | 2016 | 27225916 | |
| awareness of hepatitis 'b' among people of khyber pakhtunkhwa province of pakistan. | hepatitis b virus is causing serious health concerns in countries like pakistan. in khyber pakhtunkhwa province, 0.6 milion people were estimated to be infected with this virus in 2008. the authors aimed to assess knowledge regarding vaccination, testing and routes of transmission of hepatitis b virus among people of khyber pakhtunkhwa, as such knowledge among masses will help limit the infection. people belonging to 12 different districts of khyber pakhtunkhwa province were interviewed over a p ... | 2016 | 27225157 |
| retrospective study of phospholipase a2 receptor and igg subclasses in glomerular deposits in chinese patients with membranous nephropathy. | the research work in the past years showed that detection of phospholipase a2 receptor (pla2r) antigen and its dominant igg4 autoantibody in glomerular deposits of patients with membranous nephropathy (mn) was useful for the differentiation between primary mn (pmn) and secondary mn (smn), but so far such research data from large chinese patient series is little. here, we are going to report a research work in a chinese cohort. | 2016 | 27223897 |
| [hepatitis b virus genotypes and evolutionary markers in chronic hbsag patients in bujumbura]. | hepatitis b virus infection (vhb) is a serious condition which can lead to serious complications, such as cirrhosis and hepato-cellular carcinoma (hcc). hbv genotypes greatly influence its evolution and the effectiveness of treatment. the aim was to evaluate the hbv genotypes and the evolutionary pathways of chronic hbsag patients. | 2016 | 27222687 |
| seroprevalence of human immunodeficiency virus, hepatitis b virus, hepatitis c virus, and syphilis among blood donors at jigjiga blood bank, eastern ethiopia. | transfusion-transmissible infectious agents such as human immunodeficiency virus (hiv), hepatitis b virus (hbv), hepatitis c virus (hcv), and syphilis are among the greatest threats to blood safety for recipients. they are also the leading causes of death and chronic and life-threatening abnormalities. | 2016 | 27222628 |
| nutrition status and small intestinal bacterial overgrowth in patients with virus-related cirrhosis. | malnutrition and small intestinal bacterial overgrowth (sibo) is frequently present in patients with liver cirrhosis (lc). however, the direct relationship between sibo and nutrition status in the lc patients has not been elucidated. the aim of this study was to investigate whether there was an association between nutrition status, evaluated by the subjective global assessment (sga) and sibo in patients with hepatitis b virus (hbv) or hepatitis c virus (hcv) related cirrhosis. a total of 120 pat ... | 2016 | 27222411 |
| network signatures of igg immune repertoires in hepatitis b associated chronic infection and vaccination responses. | the repertoire of igg antibody responses to infection and vaccination varies depending on the characteristics of the immunogen and the ability of the host to mount a protective immune response. chronic hepatitis b virus (hbv) infections are marked by persistent infection and immune tolerance to vaccination. this disease offers a unique opportunity to discover key repertoire signatures during infection and in response to vaccination. complementarity determining region 3 of an antibody heavy chain ... | 2016 | 27222149 |
| distribution of glutathione s-transferase omega gene polymorphism with different stages of hbv infection including hepatocellular carcinoma in the egyptian population. | infection with hepatitis b virus (hbv) is a major global public health problem, with a wide spectrum of clinical manifestations. human cytosolic glutathione-s-transferases (gsts) include several classes such as alpha (a), mu (m), pi (p), sigma (s), zeta (z), omega (o) and theta (t). the present study aimed to investigate the role of gst omega genes (gsto1 and gsto2) in different groups of patients infected with hbv. | 2016 | 27221910 |
| association of pinx1 but not tep1 polymorphisms with progression to hepatocellular carcinoma in thai patients with chronic hepatitis b virus infection. | hepatocellular carcinoma (hcc) is major health problem with high mortality rates, especially in patients with hepatitis b virus (hbv) infection. telomerase function is one of common mechanisms affecting genome stability and cancer development. recent studies demonstrated that genetic polymorphisms of telomerase associated genes such as telomerase associated protein 1 (tep1) rs1713449 and pin2/terf1-interacting telomerase inhibitor 1 (pinx1) rs1469557 may be associated with risk of hcc and other ... | 2016 | 27221889 |
| analysis of the complementarity determining regions β-chain genomic rearrangement using high-throughput sequencing in periphery cytotoxic t lymphocytes of patients with chronic hepatitis b. | cytotoxic t lymphocytes (ctls) are important for the recognition of the hepatitis b virus (hbv), mediating immunoprotective mechanisms and determining the clinical outcome following hbv infection. ctls recognize the invading virus via the t cell receptor (tcr). the aim of the current study was to investigate the variability of tcr in lymphocytes from patients with chronic hepatitis b and whether tcr genomic recombination is regulated by the current treatment strategies. peripheral blood mononucl ... | 2016 | 27221081 |
| short-term efficacy of treating hepatitis b virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs: a randomized controlled trial. | to evaluate the clinical efficacy and safety of yinchen zhufu decoction (, yczfd) in the treatment of acute-on-chronic liver failure caused by hepatitis b virus (hbv-aclf) with cold pattern in chinese medicine (cm). | 2016 | 27220737 |
| high prevalence of diffuse large b-cell lymphoma in occult hepatitis b virus-infected patients in the tohoku district in eastern japan. | occult hepatitis b virus (hbv) infection is a clinical challenge, but its relationship to clinicopathologic features and the risk of progression to malignant lymphoma (ml) are poorly defined. we estimated the prevalence of hbv infection of 1,358 patients with newly diagnosed ml. hbv infection was more prevalent in ml than in control patients. the occult hbv infection group had a higher median onset age, no liver or spleen involvement, and higher prevalence of diffuse large b-cell lymphoma than t ... | 2016 | 27219865 |
| veterans health administration hepatitis b testing and treatment with anti-cd20 antibody administration. | to evaluate pretreatment hepatitis b virus (hbv) testing, vaccination, and antiviral treatment rates in veterans affairs patients receiving anti-cd20 ab for quality improvement. | 2016 | 27217704 |
| 5-year efficacy of entecavir in indian patients with chronic hepatitis b. | entecavir, a drug with high potency and genetic barrier against hepatitis b virus, was believed to become very effective in reducing the hepatitis b burden in india. long-term studies on its treatment outcome are scarce. | 2016 | 27216583 |
| undocumented migrant women in denmark have inadequate access to pregnancy screening and have a higher prevalence hepatitis b virus infection compared to documented migrants in denmark: a prevalence study. | pregnant residents of denmark are tested by their gp for current infections with hepatitis b virus (hbv), hiv and syphilis through the danish pregnancy screening programme to identify infections and initiate interventions to prevent mother-to-child transmission. documented migrants (dm) have access to this screening but undocumented migrants (um) do not, instead relying on ad-hoc care from clinics run by non-governmental organisations. we aimed to assess screening frequency in um and to compare ... | 2016 | 27216405 |
| the role of hepatitis e virus infection in adult americans with acute liver failure. | acute hepatitis e virus (hev) infection is a leading cause of acute liver failure (alf) in many developing countries, yet rarely identified in western countries. given that antibody testing for hev infection is not routinely obtained, we hypothesized that hev-related alf might be present and unrecognized in north american alf patients. serum samples of 681 adults enrolled in the u.s. acute liver failure study group were tested for anti-hev immunoglobulin (ig) m and anti-hev igg levels. subjects ... | 2016 | 27215797 |
| clinicopathological correlations of renal pathology: a single center experience. | to evaluate the clinicopathological correlation of renal pathology and outline the frequencies of different renal diseases, beside assessment of lupus nephritis (ln), we studied 150 patients [72 (48%) males and mean age of 33.82 ± 15.4 years] who were subjected to native renal biopsy; 112 (72.8%) biopsied patients were diagnosed to have glomerulonephritis (gn). the most frequent clinical renal syndrome was nephrotic syndrome found in 55 (36.6%) patients, followed by nephritic syndrome in 38 (25. ... | 2016 | 27215250 |
| living donor liver transplantation indicated for compensated liver cirrhosis with symptomatic gallstone diseases: report of two cases. | surgical interventions for symptomatic gallstone disease could be dangerous in patients with severe comorbid conditions including liver cirrhosis. here, we report our experience of living donor liver transplantation (ldlt) indicated for two patients with liver cirrhosis complicated with gallstone diseases. | 2016 | 27215224 |
| hepatitis b serology and dna detection in multitransfused haemophiliacs and factor viii and ix concentrates. | to assess the effect of hiv infection and the introduction of virus-inactivated concentrates, we conducted a retrospective 20-year longitudinal study of hepatitis b virus (hbv) serology and look for hbv dna in recent serum samples of 63 multiply transfused haemophiliacs. of 63 haemophiliacs, 51 had evidence of previous hbv infection and 12 vaccinees had anti-hbs only. of 40 hiv-negative, two had persistent hbsag but all were hbv dna negative. all 23 hiv-positive were hbsag-negative. loss of anti ... | 1996 | 27214362 |
| viral load pattern among hepatitis b surface antigen-positive patients: laboratory perspective and implications for therapy. | hepatitis b viral infection is an old medical problem with worldwide distribution. it is usually diagnosed using serologic methods. however, the decision as to which patient to treat or not remains challenging due to the poor sensitivity of serologic markers as prognostic or severity markers. viral load (vl) determination using polymerase chain reaction techniques is a useful tool in decision-making. | 2017 | 27213092 |
| conjoined unification venoplasty for triple portal vein branches of right liver graft: a case report and technical refinement. | anomalous portal vein (pv) branching of the donor liver is uncommon and usually makes two, or rarely, more separate pv branches at the right liver graft. autologous pv y-graft interposition has long been regarded as the standard procedure, but is currently replaced with the newly developed technique of conjoined unification venoplasty (cuv) due to its superior results. herein, we presented a case of cuv application to three pv openings of a right liver graft. the recipient was a 32-year-old male ... | 2016 | 27212992 |
| genetic variant in cxcl13 gene is associated with susceptibility to intrauterine infection of hepatitis b virus. | intrauterine infection of hepatitis b virus (hbv), which accounts for the majority of mother-to-child transmission, is one of the main reasons for the failure of combined immunoprophylaxis against the transmission. recent studies have identified that genetic background might influence the susceptibility to intrauterine infection of hbv. we conducted this study to investigate the associations between 10 genetic variants in 9 genes (slc10a1, hla-dp, hla-c, cxcr5, cxcl13, tlr3, tlr4, tlr9 and ube2l ... | 2016 | 27212637 |
| prophylaxis among hepatitis b core antibody-positive deceased-donor liver transplant recipients: hepatitis b immunoglobulin plus oral antiviral agents versus antiviral agents alone: a single-center experience. | hepatitis b core antibody immunoglobulin g seropositivity is evidence of past exposure to hepatitis b virus. donor or recipient hepatitis b core antibody positivity may pose a risk of reactivation, especially early after liver transplant. although most centers advocate using antiviral agents plus hepatitis b immunoglobulin, some have recently relied on antivirals only as prophylaxis after liver transplant. here, we retrospectively investigated patient survival in hepatitis b core antibody-positi ... | 2017 | 27212251 |
| five-year results of oral antiviral therapy in hbeag-negative chronic hepatitis b. | several guidelines recommend the use of tenofovir or entecavir as the first-line treatment for hepatitis b due to the lower resistance rates of these drugs than lamivudine, although lamivudine may still be preferred because of its low adverse effect profile and cost. it is important to know which patients might benefit from lamivudine as the first-line treatment. we aimed to assess the success rates of lamivudine, entecavir, and tenofovir, as well as the resistance rates, frequencies of hbsag cl ... | 2016 | 27210786 |
| emerging therapeutics and relevant targets for chronic hepatitis b. | chronic hepatitis b virus (hbv) infection is a global health problem for the pursuit of complete virus eradication and immunity acquisition to prevent liver disease progression. currently, interferon-alpha, with the underlying mechanism of host immunomodulation, and nucleos(t)ide analogs, with the underlying mechanism of inhibition of viral replication, are used for the treatment of patients with chronic hepatitis b. despite remarkable improvement in the virological, serological, biochemical, an ... | 2016 | 27210776 |
| decay of ccc-dna marks persistence of intrahepatic viral dna synthesis under tenofovir in hiv-hbv co-infected patients. | in the presence of highly-potent antivirals, persistence of hepatitis b virus (hbv) is most well-characterized by covalently-closed circular dna (cccdna) and total intrahepatic dna (ih-dna). we sought to determine how antiviral therapy could affect their levels during human immunodeficiency virus (hiv)-hbv co-infection. | 2016 | 27210429 |
| randomized phase ii study of gs-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis b. | gs-4774 is a heat-inactivated, yeast-based, t-cell vaccine designed to elicit hepatitis b virus (hbv)-specific t-cell responses. we evaluated the safety, tolerability and efficacy of gs-4774 in patients with chronic hbv infection. | 2016 | 27210427 |
| hepatitis b virus inhibits intrinsic rig-i and rig-g immune signaling via inducing mir146a. | previous studies showed that hepatitis b virus (hbv), as a latency invader, attenuated host anti-viral immune responses. mirnas were shown to be involved in hbv infection and hbv-related diseases, however, the precise role of mirnas in hbv-mediated immunosuppression remains unclear. here, we observed that down-regulated rig-i like receptors might be one critical mechanism of hbv-induced suppression of type i ifn transcription in both hbv(+) hepatoma cell lines and liver cancer tissues. then, mir ... | 2016 | 27210312 |
| genetic polymorphism of hla-dq confers susceptibility to hepatitis b virus-related hepatocellular carcinoma: a case-control study in han population in china. | several recent genome-wide studies showed that the genetic polymorphisms in the hla-dq region (rs9275572 and rs2856718) were related to chronic hepatitis b virus (hbv) infection and chronic hepatitis c virus (hcv)-associated hepatocellular carcinoma (hcc). we analyzed the two single-nucleotide polymorphisms for major hbv outcomes in han chinese. a total of 1291 samples were involved and peripheral blood samples were collected in this study. matrix-assisted laser desorption/ionization time of fli ... | 2016 | 27209411 |
| natural killer cells contribute to hepatic injury and help in viral persistence during progression of hepatitis b e-antigen-negative chronic hepatitis b virus infection. | hepatitis b e-antigen negative (e(-)) chronic hbv infection (chi) encompasses a heterogeneous clinical spectrum ranging from inactive carrier (ic) state to e(-) chronic hepatitis b (chb), cirrhosis and hepatic decompensation. in the backdrop of dysfunctional virus-specific t cells, natural killer (nk) cells are emerging as innate effectors in chi. we characterized cd3(-) cd56(+) nk cells in clinically well-defined, treatment-naive e(-) patients in ic, e(-)chb or decompensated liver cirrhosis (lc ... | 2016 | 27208430 |
| seroprevalence of hepatitis b and c among domestic and healthcare waste handlers in belo horizonte, brazil. | infection with the hepatitis b and c viruses may occur through contact with infected body fluids, including injury with infected sharps. collectors of domestic or healthcare wastes are potentially exposed to these infections. the aim of this article is to investigate the risk factors associated with the prevalence of hepatitis b and c viruses (hbv and hcv) infection among domestic and healthcare waste workers in belo horizonte, brazil. a cross-sectional study of hepatitis b and c infection was c ... | 2016 | 27207769 |
| cost-effective in-house neutralization assay for the confirmation of hbeag. | hepatitis b virus-e-antigen (hbeag) is an affordable viral marker to assess viral replication kinetics and response to antiviral therapy. in the absence of confirmatory assays, discrepant or false-positive hbeag results are resolved by screening for other hbv markers. we standardized an in-house hbeag neutralization assay (hbeag-nt) to confirm hbeag in clinical samples. | 2016 | 27207380 |
| graves' hyperthyroidism accompanied with acute hepatitis b virus infection: an extrahepatic manifestation? | although hepatitis b virus (hbv) primarily affects hepatocytes, it has also been shown to cause complications in the skin, joints, muscles, and kidneys. thyroid dysfunction is uncommon in cases of acute hbv infection. | 2016 | 27206523 |
| survey of hepatitis b knowledge and stigma among chronically infected patients and uninfected persons in beijing, china. | hepatitis b virus (hbv) infection carries substantial stigma in china. we surveyed hbv knowledge and stigma among chronic hepatitis b (chb) patients and persons without hbv infection in beijing, china. | 2016 | 27206379 |
| complete spectrum of crispr/cas9-induced mutations on hbv cccdna. | hepatitis b virus (hbv) causes chronic infections that cannot yet be cured. the virus persists in infected hepatocytes, because covalently closed circular dna (cccdna), the template for the transcription of viral rnas, is stable in nondividing cells. antiviral therapies with nucleoside analogues inhibit hbv dna synthesis in capsids in the cytoplasm of infected hepatocytes, but do not destroy nuclear cccdna. because over 200 million people are still infected, a cure for chronic hepatitis b (chb) ... | 2016 | 27203444 |
| subclinical ascites does not affect the long-term prognosis in hepatitis b virus-related cirrhosis patients receiving antivirals. | this study evaluated the clinical significance of subclinical ascites in patients with hepatitis b virus-related cirrhosis treated with lamivudine (lmv) or entecavir (etv). | 2016 | 27203430 |
| quantitative assessment of mutations in hepatitis b virus genome with liver cirrhosis and hepatocellular carcinoma development. | the long-term outcomes of liver cirrhosis (lc) and hepatocellular carcinoma (hcc) in patients with chronic hepatitis b virus (hbv) infection are associated with specific hbv genotypes and mutations in the virus genome. however, a number of gene-disease association studies have yielded inconsistent results in the field. to investigate this inconsistency, we conducted a meta-analysis from 118 studies involving a total of 9,418 hcc cases, 2,697 lc cases, and 18,785 hbv-infected participants for 11 ... | 2016 | 27203218 |
| persistence to treatment of chronic hepatitis b virus (hbv) infection: a study based on the french ims lifelink treatment dynamics (ltd) database. | 2014 | 27202519 | |
| cost analysis for management and prevention of hepatitis b virus reactivation. | 2014 | 27202452 | |
| lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis b virus-associated hepatocellular carcinoma patients after curative hepatectomy. | lymphocytes are an integral part of lymphocyte to monocyte ratio (lmr) and prognostic nutritional index (pni). both lmr and pni which reflect body's inflammatory and nutritional status can be obtained from routine blood and biochemical test conveniently. little evidence concerning the prognostic value of lmr and pni in hepatocellular carcinoma (hcc) patients has been published. this study aimed to investigate the prognostic value of lmr and pni in hepatitis b virals (hbv)-associated hcc patients ... | 2016 | 27199001 |
| review article: long-term safety of nucleoside and nucleotide analogues in hbv-monoinfected patients. | nucleos(t)ide analogues (nucs) for chronic hepatitis b treatment achieve high rates of viral suppression and are generally well tolerated. entecavir (etv) and tenofovir disoproxil fumarate (tdf) are the currently preferred first-line agents. the safety of these agents in clinical practice is particularly relevant since long-term treatment is usually required. | 2016 | 27198929 |
| fluctuation of viremia in hepatitis b virus-infected healthcare workers performing exposure-prone procedures in the netherlands. | to determine the longitudinal changes in viral load of hepatitis b virus (hbv)-infected healthcare workers (hcws) and its consequences for exclusion of infected hcws performing exposure-prone procedures, various hbv dna safety thresholds, and the frequency of monitoring. | 2016 | 27198603 |
| prevention of perinatal transmission of hepatitis b virus: assessment among wisconsin maternity hospitals. | to evaluate the completeness of identification of pregnant women testing positive for hepatitis b surface antigen (hbsag) and birth dose hepatitis b vaccine administration, and the extent of appropriate prophylaxis of infants born to women with and without maternal hbsag status documented in the infant medical record. | 2016 | 27197340 |
| statin-induced liver injury in an area endemic for hepatitis b virus infection: risk factors and outcome analysis. | statin-induced liver injury (sili) is quite rare, but may be severe. little is known about the impact of chronic hepatitis b infection (chbi) on sili. we aimed to investigate the risk factors and outcome of sili, with special reference to its interaction with chbi. | 2016 | 27197051 |
| barriers to timely administration of birth dose vaccines in the gambia, west africa. | although vaccine coverage in infants in sub-saharan africa is high, this is estimated at the age of 6-12 months. there is little information on the timely administration of birth dose vaccines. the objective of this study was to assess the timing of birth dose vaccines (hepatitis b, bcg and oral polio) and reasons for delayed administration in the gambia. | 2016 | 27195759 |
| biochemical and clinical predictive approach and time point analysis of hepatobiliary phase liver enhancement on gd-eob-dtpa-enhanced mr images: a multicenter study. | purpose to identify biochemical factors associated with liver enhancement over time on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (gd-eob-dtpa)-enhanced magnetic resonance (mr) images and predict the optimal time point of the hepatobiliary phase in various clinical settings. materials and methods this study was approved by the institutional review boards, and written informed consent was obtained from the 1903 patients enrolled. simple and multiple logistic regression analyses w ... | 2016 | 27195437 |
| an evaluation of entecavir treatment among nucleos(t)ide-naïve moroccan patients with chronic hepatitis b. | to analyse the efficacy and safety of entecavir (etv) treatment in nucleos(t)ide (nuc)-naïve moroccan patients with chronic hepatitis b. | 2016 | 27195127 |
| a novel hydrodynamic injection mouse model of hbv genotype c for the study of hbv biology and the anti-viral activity of lamivudine. | absence of an immunocompetent mouse model of persistent hepatitis b virus (hbv) infection has hindered the research of hbv infection and the development of antiviral medications. | 2016 | 27195013 |
| multiplex reverse transcriptase-pcr for simultaneous detection of hepatitis b, c, and e virus. | the hepatitis b virus (hbv), hcv, and hev may occur as singly or concurrently in patients of different kind of liver disease. the rapid, reliable, and cost-effective screening of these pathogens is required for the large epidemiological studies. therefore, a study has been planned to develop a multiplex reverse transcriptase-pcr assay which can be used for the screening of maximum number of pathogens at a time. | 2016 | 27194894 |
| acute-on-chronic liver failure (aclf) in coastal eastern india: "a single-center experience". | acute-on-chronic liver failure (aclf) is an emerging entity. the present study was undertaken to analyze the clinical profile and natural course of aclf patients. | 2016 | 27194893 |