Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| posttransplant lymphoma in renal and heart allograft recipients: a single center experience. | posttransplant lymphoproliferative disorder (ptld) is a serious complication of organ transplantation, with a reported incidence between 0.8% to 32%. herein we retrospectively analyzed the patients who diagnosed as ptld in akdeniz university. within the 782 (773 renal and 9 heart) transplant recipients six patients were diagnosed as ptld (diffuse large b-cell lymphoma). five of them had renal, one had cardiac transplantation. three patients were diagnosed within the first year of transplantation ... | 2005 | 27265012 |
| epstein-barr virus latent membrane protein 1 (lmp-1) in hodgkin's lymphoma patients in turkey. | epstein-barr virus (ebv) has been implicated as a contributing factor in the development of hodgkin's lymphoma. the aim of this study was to elucidate the association of hodgkin's lymphoma with ebv in a turkish population using immunohistochemical detection of lmp-1. we studied a total of 21 consecutive cases of hodgkin's lymphoma from turkey. lmp-1 protein was detected in 9 of 21 (42.8%) cases. lmp-1 was positive in 4 of 7 (57%) mixed cellularity and 5 of 13 (38.4%) nodular sclerosis subtype. t ... | 2001 | 27264067 |
| chronic active epstein-barr virus infection with marked pericardial effusion successfully treated with allogeneic peripheral blood stem cell transplantation. | a 23-year-old woman presented with a persistent fever and shortness of breath. computed tomography showed marked pericardial effusion, hepatosplenomegaly, and cervical and mediastinal lymph node swelling. epstein-barr virus (ebv) antibody titers were abnormally elevated, and the copy number of ebv-dna was increased in peripheral blood. based on these observations, she was diagnosed with chronic active ebv infection (caebv). the ebv-infected cells in her peripheral blood were cd4(+)t lymphocytes. ... | 2016 | 27263789 |
| intense myelofibrosis in a child: unusual result of ebv-associated hemophagocytic lymphohistiocytosis. | a previously healthy 12-year-old girl was admitted to the intensive care unit with severe pulmonary bleeding. her history revealed that she had suffered from high fever, fatigue, sore throat, myalgia and generalized rash for two weeks. physical examination revealed hepatosplenomegaly. laboratory investigation showed pancytopenia associated with unusual high levels of serum ferritin, triglyceride and lactate dehydrogenase (ldh) and low fibrinogen levels. apparent hemophagocytosis was seen in bone ... | 2007 | 27263483 |
| [myeloradiculitis due to epstein-barr virus reactivation in a hodgkin's lymphoma patient]. | 2016 | 27262573 | |
| the impact of long-term secukinumab treatment on epstein-barr virus and cytomegalovirus loads in patients with psoriasis. | 2016 | 27261186 | |
| pd-l1 expression is associated with massive lymphocyte infiltration and histology in gastric cancer. | the mechanism of carcinogenesis of gastric cancer (gc) is still unclear now. this study aimed to explore the correlations among pd-l1, epstein-barr virus (ebv) infection, lymphocyte infiltration, her2 expression, her2 gene status, histology, and other clinicopathological factors in gc. a total of 44 gc patients with massive lymphocyte infiltration (gc-mli) and 93 gc patients without massive lymphocyte infiltration were involved in this study. immunohistochemical analysis was used to test the exp ... | 2016 | 27260946 |
| post-transplant lymphoproliferative disorder of the pediatric airway: presentation and management. | post-transplant lymphoproliferative disorder (ptld) is a rare complication of immunosuppression with little consensus on its evaluation and management. the purpose of this contemporary review is to describe a pediatric patient with ptld of the airway and review the literature to provide multidisciplinary recommendations regarding management. | 2016 | 27260610 |
| brief report: cd14brightcd16- monocytes and scd14 level negatively associate with cd4-memory t-cell frequency and predict hcv-decline on therapy. | during hiv+ hepatitis c virus (hcv)+ coinfection cd14cd16 monocytes produce soluble immune-activation markers that predict disease progression and poor response to interferon (ifn)-α treatment. we evaluated relationships among immune activation, monocyte phenotype, cd4-memory t cells, and hcv-, cytomegalovirus-, and cytomegalovirus/epstein-barr virus/influenza-specific ifn-γ-response before and during ifn-α treatment. effector-memory and central-memory cd4 t-cell frequencies were lower in hcv+ h ... | 2016 | 27258231 |
| overexpression of pin1 enhances cancer growth and aggressiveness with cyclin d1 induction in ebv-associated nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a peculiar epstein barr virus (ebv)-associated malignancy that is prevalent in south-east asia. peptidyl-prolyl cis-trans isomerase nima-interacting 1 (pin1) isomerizes specific phosphorylated amino acid residues, which makes it an important regulator in cell survival and apoptosis. in this study, we investigated the contribution made by pin1 in npc tumorigenesis and pin1's potential role as a therapeutic target. | 2016 | 27258148 |
| evaluation of the abbot architect(™) epstein-barr virus viral capsid antigen igm, viral capsid antigen igg and nuclear antigen igg assays in a pediatric and adult population. | the detection of antibodies against epstein-barr viral capsid (vca) and nuclear (ebna) antigens is routinely performed with different commercially available immunoassays. | 2016 | 27258036 |
| [an analysis of immunophenotyping of peripheral lymphocytes in adult patients with infectious mononucleosis and chronic active epstein-barr virus infection]. | to determine the immunophenotypic features of peripheral lymphocytes in adult patients with epstein-barr virus(ebv)-associated infectious mononucleosis(im) and chronic active ebv infection (caebv). | 2016 | 27256608 |
| ebv-lmp1 suppresses the dna damage response through dna-pk/ampk signaling to promote radioresistance in nasopharyngeal carcinoma. | we conducted this research to explore the role of latent membrane protein 1 (lmp1) encoded by the epstein-barr virus (ebv) in modulating the dna damage response (ddr) and its regulatory mechanisms in radioresistance. our results revealed that lmp1 repressed the repair of dna double strand breaks (dsbs) by inhibiting dna-dependent protein kinase (dna-pk) phosphorylation and activity. moreover, lmp1 reduced the phosphorylation of amp-activated protein kinase (ampk) and changed its subcellular loca ... | 2016 | 27255972 |
| antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis. | anti-citrullinated-peptide antibodies (acpa) have been detected in individuals with developing rheumatoid arthritis (ra) before the onset of symptom, with an initially limited spectrum of reactivities that gradually broadens. the aim was to analyze the evolution of acpa response pre-dating symptom onset, using four selected citrullinated exogenous and endogenous antigens. | 2016 | 27255888 |
| the ankylosing spondylitis-associated hla-b*2705 presents a b*0702-restricted ebv epitope and sustains the clonal amplification of cytotoxic t cells in patients. | hla-b*27 is strongly associated with an inflammatory autoimmune disorder, the ankylosing spondylitis (as) and plays a protective role in viral infections. the two aspects might be linked. in this work, we compared in b*2705/b*07 positive patients with as, the cd8+ t cell responses to two immunodominant ebv-derived epitopes restricted for either the hla-b*27 (pebna3c) or the hla-b*07 (pebna3a). we have unexpectedly found that the hla-b*07-restricted ebna3a peptide is presented by both the b*0702 ... | 2016 | 27254288 |
| correlation between anti-jc-virus and anti-cytomegalovirus, -epstein-barr virus and -measles/-rubella/-varicella-zoster-virus antibodies. | anti-jcv antibody status is used for pml-risk-stratification in ms patients before and during natalizumab therapy. jcv antibodies can be detected in around 60% of ms patients, however, only a small proportion actually develop pml. as anti-viral antibodies tend to occur unspecifically, the aim of this study was to correlate jcv antibody status and index with other common anti-viral antibodies. a total of 123 samples of ms-patients were tested for anti-jcv antibodies by jcv-stratify-elisa at unila ... | 2017 | 27253624 |
| cd1c-related dcs that express cd207/langerin, but are distinguishable from langerhans cells, are consistently present in human tonsils. | several subsets of dendritic cells (dcs) are present in the oropharyngeal tonsillar tissues and are thought to behave as major actors in development and regulation of immunity by acting as a first line of recognition for airborne and alimentary antigens. we previously discovered in human adult tonsils infected with epstein-barr virus (ebv), a subset of dcs that expressed langerin/cd207, a lectin usually recognized as a hallmark of epidermal langerhans cells (lcs). in the present study, we analyz ... | 2016 | 27252701 |
| cytomegalovirus and epstein-barr virus infections. | 2016 | 27252178 | |
| risk factors and utility of a risk-based algorithm for monitoring cytomegalovirus, epstein-barr virus, and adenovirus infections in pediatric recipients after allogeneic hematopoietic cell transplantation. | infectious complications, particularly viral infections, remain a significant cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (allohct). only a handful of studies in children have analyzed the risks for and impact of viremia on allohct-related outcomes. we conducted a retrospective study of 140 pediatric patients undergoing allohct to investigate the incidence of and risk factors for cytomegalovirus (cmv), adenovirus (adv), and epstein-barr virus (ebv) viremi ... | 2016 | 27252110 |
| partial least square discriminant analysis discovered a dietary pattern inversely associated with nasopharyngeal carcinoma risk. | evidence on the association between dietary component, dietary pattern and nasopharyngeal carcinoma (npc) is scarce. a major challenge is the high degree of correlation among dietary constituents. we aimed to identify dietary pattern associated with npc and to illustrate the dose-response relationship between the identified dietary pattern scores and the risk of npc. taking advantage of a matched npc case-control study, data from a total of 319 incident cases and 319 matched controls were analyz ... | 2016 | 27249558 |
| viral oncomir spreading between b and t cells is employed by kaposi's sarcoma herpesvirus to induce non-cell-autonomous target gene regulation. | the two human lymphotrophic γ-herpesviruses, kaposi's sarcoma herpesvirus (kshv) and epstein-barr virus (ebv), are a recognized cause of human cancer, encoding multiple mirs that are major players in carcinogenesis. previously, we discovered that ebv-encoded mirs transfer between infected b and t lymphocytes. to further explore the biological significance of the spreading of γ-herpesvirus-encoded mirs on carcinogenesis, we focused on kshv-mir-k12-11 (mir-k12-11) that is unique in having an ident ... | 2016 | 27248822 |
| epstein-barr virus-induced gene 3 (ebi3) blocking leads to induce antitumor cytotoxic t lymphocyte response and suppress tumor growth in colorectal cancer by bidirectional reciprocal-regulation stat3 signaling pathway. | epstein-barr virus-induced gene 3 (ebi3) is a member of the interleukin-12 (il-12) family structural subunit and can form a heterodimer with il-27p28 and il-12p35 subunit to build il-27 and il-35, respectively. however, il-27 stimulates whereas il-35 inhibits antitumor t cell responses. to date, little is known about the role of ebi3 in tumor microenvironment. in this study, firstly we assessed ebi3, il-27p28, il-12p35, gp130, and p-stat3 expression with clinicopathological parameters of colorec ... | 2016 | 27247488 |
| development of a low-cost stem-loop real-time quantification pcr technique for ebv mirna expression analysis. | micrornas (mirnas) are short, single stranded, non-coding rna molecules. they are produced by many different species and are key regulators of several physiological processes. mirnas are also encoded by the genomes of multiple virus families, such as herpesvirus family. in particular, mirnas from epstein barr virus were found at high concentrations in different associated pathologies, such as burkitt's lymphoma, hodgkin disease, and nasopharyngeal carcinoma. thanks to their stability, these mole ... | 2016 | 27246439 |
| hemophagocytic lymphohistiocytosis in children: pathogenesis and treatment. | hemophagocytic lymphohistiocytosis (hlh) is a rare disorder in children that is characterized by persistent fever, splenomegaly with cytopenia, hypertriglyceridemia, and hypofibrinogenemia. increased levels of various cytokines and soluble interleukin-2 receptor are biological markers of hlh. hlh can be classified into two major forms: primary and secondary. familial hemophagocytic lymphohistiocytosis (fhl), a type of primary hlh, is an autosomal recessive disorder that typically occurs in infan ... | 2016 | 27242976 |
| mirna expression profiling of epstein-barr virus-associated nktl cell lines by illumina deep sequencing. | the aim of this work was to establish the microrna profile of snk6 and snt16, two epstein-barr virus (ebv)-infected cell lines derived from nasal nk/t-cell lymphoma (nktl). the oncogenic ebv is strongly associated with the pathogenesis of nasal and extranodal nk/t-cell lymphoma and expresses 44 mature micrornas and two noncoding ebv-encoded rnas (ebers). mirnas are 19-25nt noncoding rnas that affect host and viral gene expression post-transcriptionally. deregulated mirna patterns are frequently ... | 2016 | 27239439 |
| redirecting t cell specificity using t cell receptor messenger rna electroporation. | autologous t lymphocytes genetically modified to express t cell receptors or chimeric antigen receptors have shown great promise in the treatment of several cancers, including melanoma and leukemia. in addition to tumor-associated antigens and tumor-specific neoantigens, tumors expressing viral peptides can also be recognized by specific t cells and are attractive targets for cell therapy. hepatocellular carcinoma cells often have hepatitis b virus dna integration and can be targeted by hepatiti ... | 2016 | 27236807 |
| human herpesvirus type 8-associated large b-cell lymphoma: a nonserous extracavitary variant of primary effusion lymphoma in an hiv-infected man: a case report and review of the literature. | primary effusion lymphoma (pel) is a rare non-hodgkin lymphoma subtype primarily seen in human immunodeficiency virus (hiv)-infected individuals with low cd4(+) cell counts and elevated hiv viral loads. it has always been associated with human herpesvirus type 8 (hhv-8) and in 80% of cases has also been associated with epstein-barr virus (ebv). less commonly, pel has presented in patients with advanced age and other conditions associated with an altered immunity, including malignancy, liver cirr ... | 2016 | 27234438 |
| emerging molecular classifications and therapeutic implications for gastric cancer. | gastric cancer (gc) is a highly aggressive and life-threatening malignancy. even with radical surgical removal and front-line chemotherapy, more than half of gcs locally relapse and metastasize at a distant site. the dismal outcomes reflect the ineffectiveness of a one-size-fits-all approach for a highly heterogeneous disease with diverse etiological causes and complex molecular underpinnings. the recent comprehensive genomic and molecular profiling has led to our deepened understanding of gc. t ... | 2016 | 27233623 |
| conjunctival angioimmunoblastic t-cell lymphoma. | angioimmunoblastic t-cell lymphoma (aitl) represents an uncommon variant of t-cell lymphomas and most often presents insidiously with systemic symptoms. this report constitutes the first documented case of conjunctival aitl, masquerading as nodular episcleritis, and describes both the clinical and pathological findings. furthermore, conjunctival t-cell lymphoma in general remains a rare occurrence, and a survey of previously reported cases reveals a wide variation in clinical presentation. a hig ... | 2015 | 27231687 |
| epstein-barr virus and carcinomas: rare association of the virus with gastric adenocarcinomas. | 2016 | 27228295 | |
| unusual indolent course of a chronic active epstein-barr virus-associated natural killer cell lymphoproliferative disorder. | natural killer (nk) cell lymphoproliferative disorders are uncommon and the epstein-barr virus (ebv) plays an important aetiological role in their pathogenesis. we report a 20-year-old male with a chronic active ebv infection associated with a nk cell lymphoproliferative disorder which had an unusual indolent course. he presented to the sultan qaboos university hospital in muscat, oman, in december 2011 with a history of intermittent fever and coughing. examinations revealed generalised lymphade ... | 2016 | 27226916 |
| association of atopic diseases and parvovirus b19 with acute lymphoblastic leukemia in childhood and adolescence in the northeast of brazil. | several factors related to the immune system, such as a history of allergies and virus infections, may be associated with acute lymphoblastic leukemia (all). the purpose of this study was to analyze whether the presence of atopic diseases and previous infection with parvovirus b19 and epstein-barr virus (ebv) are associated with the development of all. | 2016 | 27225490 |
| etiological characteristics of chlamydia trachoma conjunctivitis of primary boarding school students in the qinghai tibetan area. | the aim of this study was to investigate the etiological characteristics of chlamydia trachomatis conjunctivitis among resident students at primary schools in the qinghai tibetan area in order to understand the distribution of c. trachomatis and other pathogenic microorganisms, to detect the isolation rate of infectious pathogens, and to provide an evidence for further targeted efforts in the prevent of sporadic trachoma efforts. from two primary schools in qinghai province, ocular samples from ... | 2016 | 27225259 |
| nf-κb deregulation in hodgkin lymphoma. | hodgkin and reed/sternberg (hrs) cells in classical hodgkin lymphoma (hl) show constitutive activity of both the canonical and non-canonical nf-κb signaling pathways. the central pathogenetic role of this activity is indicated from studies with hl cell lines, which undergo apoptosis upon nf-κb inhibition. multiple factors contribute to the strong nf-κb activity of hrs cells. this includes interaction with other cells in the lymphoma microenvironment through cd30, cd40, bcma and other receptors, ... | 2016 | 27221964 |
| epstein-barr virus-positive diffuse large b-cell lymphoma: is it different between over and under 50 years of age? | epstein-barr virus (ebv) positive diffuse large b-cell lymphoma (dlbcl) of the elderly is an entity introduced in the latest who classification of lymphoid tumors and defined in patients older than 50 years without prior lymphoma or immunodeficiency. however, recently it has also been seen in patients under 50. there is thus debate as to whether these are separate entities. | 2016 | 27221931 |
| association of viral infections with risk of human lymphomas, egypt. | the aim of this study was to determine and evaluate the association of different viral infections, with hepatitis b and c viruses, epstein-barr virus, cytomegalovirus and human herpes virus-8 (hbv, hcv, ebv, cmv, hhv-8) with the risk of lymphomas (hodgkin and non-hodgkin) among egyptian patients, and correlate with the histopathological staging and typing as well as the prevalence of combined infections. | 2016 | 27221841 |
| biomarkers of ebv-positive gastric cancers: loss of pten expression is associated with poor prognosis and nodal metastasis. | epstein-barr virus-positive gastric carcinoma (ebvgc) constitutes approximately 10 % of all gastric carcinoma cases. while distinct molecular features have been characterized previously, there have not been studies identifying their clinical utility. the purpose of this study was to investigate the immunohistochemistry (ihc) profile of ebvgc and to evaluate the potential clinicopathologic and prognostic significance of each marker. | 2016 | 27221363 |
| epstein-barr virus-associated leukemic lymphoma after allogeneic stem cell transplantation. | leukemic epstein-barr virus (ebv)-associated post-transplant lymphoproliferative diseases (ptld) following allogeneic hematopoietic stem cell transplantation are extremely rare. we can successfully treat an ebv-associated leukemic lymphoma patient with rituximab, cidofovir, and donor lymphocyte infusion (dli). in the present case, ebv-specific t cells that were present in the peripheral blood before rituximab administration treatment rapidly increased after dli in association with a decrease in ... | 2016 | 27218416 |
| human serum antibodies against ebv latent membrane protein 1 cross-react with α-synuclein. | to identify the epitope on α-synuclein (α-syn) to which antibodies against the epstein-barr virus (ebv) latent membrane protein 1 (lmp1) bind and to determine whether antibodies targeting this mimicry domain are present in human sera. | 2016 | 27218119 |
| serological response to epstein-barr virus early antigen is associated with gastric cancer and human immunodeficiency virus infection in zambian adults: a case-control study. | gastric cancer is one of the major causes of cancer related deaths, but data from sub-saharan africa are very scanty. the cancer genome atlas (tcga) initiative confirmed epstein-barr virus (ebv) related cancer as a distinct subtype, and we set out to look for serological evidence of its role in a sub-saharan african patient group. | 2016 | 27217871 |
| epstein-barr virus nuclear protein ebna3c directly induces expression of aid and somatic mutations in b cells. | activation-induced cytidine deaminase (aid), the enzyme responsible for induction of sequence variation in immunoglobulins (igs) during the process of somatic hypermutation (shm) and also ig class switching, can have a potent mutator phenotype in the development of lymphoma. using various epstein-barr virus (ebv) recombinants, we provide definitive evidence that the viral nuclear protein ebna3c is essential in ebv-infected primary b cells for the induction of aid mrna and protein. using lymphobl ... | 2016 | 27217538 |
| antibodies against epstein-barr virus glycoprotein gp42 for the diagnosis of nasopharyngeal carcinoma. | assessment of immunoglobulin a (iga) antibody responses to epstein-barr virus (ebv) antigen is important for the early diagnosis of nasopharyngeal carcinoma (npc). ebv glycoprotein gp42 has been shown to play an essential role in membrane fusion with b cells. the aim of the present study was to assess whether the antibodies to ebv glycoprotein gp42 in serum could be a novel marker for diagnosis of npc. | 2016 | 27215073 |
| posttransplant lymphoproliferative disorders in irish renal transplant recipients: insights from a national observational study. | posttransplant lymphoproliferative disorders (ptld) are a common malignancy after renal transplantation with a high incidence of ptld described in the first posttransplant year. we sought to determine incidence and risk determinants of ptld in irish kidney transplant recipients. | 2017 | 27214265 |
| epstein-barr virus encephalitis in an immunocompetent child: a case report and management of epstein-barr virus encephalitis. | epstein-barr virus (ebv) usually causes mild, asymptomatic, and self-limited infections in children and adults; however, it may occasionally lead to severe conditions such as neurological diseases, malignant diseases, hepatic failure, and myocarditis. epstein-barr virus-related neurological disorders include meningitis, encephalitis, and cranial or peripheral neuritis, which are mostly seen in immunocompromised patients. the therapeutic modalities for ebv-related severe organ damage including ce ... | 2016 | 27213062 |
| rec8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in ebv-positive subtype. | rec8 meiotic recombination protein (rec8) was found to be preferentially methylated in gastric cancer (gc) using promoter methylation array. we aimed to elucidate the epigenetic alteration and biological function of rec8 in gc. rec8 was downregulated in 100% (3/3) of epstein-barr virus (ebv)-positive and 80% (8/10) of ebv-negative gc cell lines by promoter methylation, but the expression could be restored through demethylation treatment. protein expression of rec8 was significantly lower in huma ... | 2017 | 27212034 |
| t cells for viral infections after allogeneic hematopoietic stem cell transplant. | despite recent advances in the field of allogeneic hematopoietic stem cell transplantation (hsct), viral infections are still a major complication during the period of immune suppression that follows the procedure. adoptive transfer of donor-derived virus-specific cytotoxic t cells (vsts) is a strategy to rapidly restore virus-specific immunity to prevent or treat viral diseases after hsct. early proof of principle studies demonstrated that the administration of donor-derived t cells specific fo ... | 2016 | 27207801 |
| weathering a cytokine storm: a case of ebv-induced hemophagocytic lymphohistiocytosis. | hemophagocytic lymphohistiocytosis (hlh) is a rare but life-threatening disease caused by excessive immune activation. acquired hlh is seen in adults and is often caused by infection or malignancy. diagnosis is difficult and usually missed as clinical and laboratory findings are nonspecific. moreover, the pathophysiology of the systemic inflammatory response syndrome and/or sepsis is remarkably similar to hlh. thus, in patients presenting with presumed severe sepsis or septic shock complicated b ... | 2017 | 27200381 |
| primary thyroid extranasal nk/t-cell lymphoma associated with good outcome: a case report and literature review: a care-compliant article. | most thyroid lymphomas are b-lineage, and t-cell lymphomas are rare. none of primary thyroid extranasal nk/t-cell lymphoma (nktcl) has been reported in the literature. here, we report a case of extranasal nktcl exclusively arising in the thyroid in an 18-year-old chinese.the patient presented with rapid anterior swelling at the neck and aggravated dyspnea for 2 months. neck computer tomography scan revealed diffuse thyroid enlargement in the left lobe compressing the trachea. the thyroid functio ... | 2016 | 27196451 |
| leiomyoma in a renal allograft. | leiomyomas are smooth muscle tumours that are rarely found in the kidney. there is one report of a leiomyoma in a kidney transplant in a paediatric recipient. here, we report an adult renal transplant recipient who developed an epstein-barr virus-positive leiomyoma in his allograft 15 years after transplantation. the patient was converted to everolimus for posttransplant immunosuppression management and there was no sign of progression over a year. | 2016 | 27195169 |
| acute retinal necrosis associated with epstein-barr virus in a patient undergoing immunosuppressive therapy. | acute retinal necrosis (arn) is a rapidly progressive and severe retinitis resulting in a poor visual outcome. infections caused by herpes viruses such as herpes simplex virus (hsv) types 1 and 2 or the varicella zoster virus (vzv) are known to be implicated in the development of arn. in the present study, an 80-year-old female with arn was examined. she had been affected with rheumatoid arthritis and had taken methotrexate for over 10 years. her right eye showed clinical features of arn, and he ... | 2017 | 27194989 |
| role of human papillomavirus and tumor suppressor genes in oral cancer. | the incidence of oral cancer remains high and is associated with many deaths in both western and asian countries. several risk factors for the development of oral cancer are now well known, including smoking, drinking and consumption of smokeless tobacco products. genetic predisposition to oral cancer has been found in certain cases, but its components are not yet entirely clear. in accordance with the multi-step theory of carcinogenesis, the natural history of oral cancer seems to gradually evo ... | 2017 | 27194871 |
| epstein-barr virus-positive gastric cancer: a distinct molecular subtype of the disease? | approximately 90% of the world population is infected by epstein-barr virus (ebv). usually, it infects b lymphocytes, predisposing them to malignant transformation. infection of epithelial cells occurs rarely, and it is estimated that about to 10% of gastric cancer patients harbor ebv in their malignant cells. given that gastric cancer is the third leading cause of cancer-related mortality worldwide, with a global annual incidence of over 950,000 cases, ebv-positive gastric cancer is the largest ... | 2016 | 27192582 |
| long-term clinical outcome in nasopharyngeal carcinoma patients with post-radiation persistently detectable plasma ebv dna. | to investigate the long-term clinical outcome of nasopharyngeal carcinoma (npc) patients with persistently detectable plasma ebv (pebv) dna after curative radiotherapy (rt). | 2016 | 27191654 |
| identification and characterization of epstein-barr virus genomes in lung carcinoma biopsy samples by next-generation sequencing technology. | epstein-barr virus (ebv) has been detected in the tumor cells of several cancers, including some cases of lung carcinoma (lc). however, the genomic characteristics and diversity of ebv strains associated with lc are poorly understood. in this study, we sequenced the ebv genomes isolated from four primary lc tumor biopsy samples, designated lc1 to lc4. comparative analysis demonstrated that lc strains were more closely related to gd1 strain. compared to gd1 reference genome, a total of 520 variat ... | 2016 | 27189712 |
| post-transplant lymphoproliferative disorders. | post-transplant lymphoproliferative disorders (ptlds) are a group of conditions that involve uncontrolled proliferation of lymphoid cells as a consequence of extrinsic immunosuppression after organ or haematopoietic stem cell transplant. ptlds show some similarities to classic lymphomas in the non-immunosuppressed general population. the oncogenic epstein-barr virus (ebv) is a key pathogenic driver in many early-onset cases, through multiple mechanisms. the incidence of ptld varies with the type ... | 2016 | 27189056 |
| (18)f-fdg pet/ct findings in acute epstein-barr virus infection mimicking malignant lymphoma. | we present a case demonstrating the diagnostic work-up and follow-up of a patient with acute epstein-barr virus (ebv) infection in which the clinical picture and imaging on (18)f-fdg pet/ct mimicked malignant lymphoma. follow-up (18)f-fdg pet/ct scan in the patient performed 7 weeks after the abnormal scan revealed complete resolution of the metabolically active disease in the neck, axillas, lung hili, and spleen. this case highlights inflammation as one of the most well established false positi ... | 2016 | 27187482 |
| pd-1/ctla-4 blockade inhibits epstein-barr virus-induced lymphoma growth in a cord blood humanized-mouse model. | epstein-barr virus (ebv) infection causes b cell lymphomas in humanized mouse models and contributes to a variety of different types of human lymphomas. t cells directed against viral antigens play a critical role in controlling ebv infection, and ebv-positive lymphomas are particularly common in immunocompromised hosts. we previously showed that ebv induces b cell lymphomas with high frequency in a cord blood-humanized mouse model in which ebv-infected human cord blood is injected intraperitone ... | 2016 | 27186886 |
| primary effusion lymphoma (pel)-like lymphoma in a child with congenital immunodeficiency. | primary effusion lymphoma (pel) is a rare lymphoma that occurs more frequently in immunocompromised adults and has a poor survival. we report a 9-year-old female with combined immunodeficiency with an epstein-barr virus positive/human herpes virus 8 negative pel-like lymphoma. the treatment with systemic chemotherapy for non-hodgkin lymphoma, zidovudine, and interferon-α failed to control disease progression. this is the first reported pediatric case of pel-like lymphoma. increased diagnostic aw ... | 2016 | 27186682 |
| luteolin inhibits epstein-barr virus lytic reactivation by repressing the promoter activities of immediate-early genes. | the lytic reactivation of epstein-barr virus (ebv) has been reported to be strongly associated with several human diseases, including nasopharyngeal carcinoma (npc). inhibition of the ebv lytic cycle has been shown to be of great benefit in the treatment of ebv-associated diseases. the administration of dietary compounds is safer and more convenient than other approaches to preventing ebv reactivation. we screened several dietary compounds for their ability to inhibit ebv reactivation in npc cel ... | 2016 | 27185626 |
| hodgkin lymphoma variant of richter transformation: morphology, epstein-barr virus status, clonality, and survival analysis-with comparison to hodgkin-like lesion. | hodgkin/reed-sternberg (hrs) cells in the setting of chronic lymphocytic leukemia (cll) exist in 2 forms: type i with isolated hrs cells in a cll background (hodgkin-like lesion) and type ii with typical classic hodgkin lymphoma, a variant of richter transformation (chl-rt). the clinical significance of the 2 morphological patterns is unclear, and their biological features have not been compared. we retrospectively reviewed 77 cases: 26 of type i and 51 of type ii chl-rt; 3 cases progressed from ... | 2016 | 27184478 |
| a pre-eclampsia-associated epstein-barr virus antibody cross-reacts with placental gpr50. | to characterize antibody specificities associated with pre-eclampsia (pe), bacterial displayed peptide library screening and evolution was applied to identify peptide epitopes recognized by plasma antibodies present in women with pe near the time of delivery. pre-eclamptic women exhibited elevated igg1 titers towards a peptide epitope krpscigck within the epstein-barr virus nuclear antigen 1 (ebna-1). ebna-1 epitope antibodies cross-reacted with a similar epitope within the extracellular n-termi ... | 2016 | 27181993 |
| autoimmune limbic encephalitis and syndrome of inappropriate antidiuretic hormone secretion associated with lamotrigine-induced drug rash with eosinophilia and systemic symptoms (dress) syndrome. | drug rash with eosinophilia and systemic symptoms (dress) is a severe drug hypersensitivity reaction characterized by rash, fever and multi-organ failure. limbic encephalitis (le) is a rare disorder characterized by cognitive dysfunction with memory disturbance, seizures and psychiatric symptoms. we herein present an unusual case of dress syndrome due to lamotrigine with reactivation of epstein-barr virus, which developed autoimmune le and syndrome of inappropriate antidiuretic hormone secretion ... | 2016 | 27181555 |
| a single exercise bout enhances the manufacture of viral-specific t-cells from healthy donors: implications for allogeneic adoptive transfer immunotherapy. | cytomegalovirus (cmv) and epstein-barr virus (ebv) infections remain a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (hsct). the adoptive transfer of donor-derived viral-specific cytotoxic t-cells (vsts) is an effective treatment for controlling cmv and ebv infections after hsct; however, new practical methods are required to augment the ex vivo manufacture of multi-vsts from healthy donors. this study investigated the effects of a single exercis ... | 2016 | 27181409 |
| micrornas serving as potential biomarkers and therapeutic targets in nasopharyngeal carcinoma: a critical review. | despite significant medical advancement, nasopharyngeal carcinoma (npc) remains one of the most difficult cancers to detect and treat where it continues to prevail especially among the asian population. mirnas could act as tumour suppressor genes or oncogenes in npc. they play important roles in the pathogenesis of npc by regulating specific target genes which are involved in various cellular processes and pathways. in particular, studies on mirnas related to the epstein barr virus (ebv)-encoded ... | 2016 | 27179594 |
| human papillomavirus promotes epstein-barr virus maintenance and lytic reactivation in immortalized oral keratinocytes. | epstein-barr virus and human papillomaviruses are human tumor viruses that infect and replicate in upper aerodigestive tract epithelia and cause head and neck cancers. the productive phases of both viruses are tied to stratified epithelia highlighting the possibility that these viruses may affect each other's life cycles. our lab has established an in vitro model system to test the effects of ebv and hpv co-infection in stratified squamous oral epithelial cells. our results indicate that hpv inc ... | 2016 | 27179345 |
| multifocal epstein-barr virus-negative posttransplantation lymphoproliferative disorder treated with reduction of immunosuppression. | posttransplantation lymphoproliferative disorder (ptld) is associated with significant mortality in kidney transplant recipients. ptld cases associated with poor prognostic factors that are refractory to reduction of immunosuppression generally require chemotherapy and immunotherapy. we present a patient with ptld who achieved complete remission after reduction of immunosuppression alone despite having a poor prognosis. a boy with a mutation in the wt1 gene developed bilateral wilms tumor at 15 ... | 2016 | 27178679 |
| clinical categories of exaggerated skin reactions to mosquito bites and their pathophysiology. | mosquito bites are skin irritating reactions, which usually resolve spontaneously without intensive medical care. however, in certain situations, mosquito bites may form a more vicious reaction, sometimes accompanying fever and systemic symptoms. in such cases, the presence of rare hematological disorders, abnormalities in eosinophils and/or association with epstein-barr virus (ebv) may underlie. importantly, hypersensitivity to mosquito bites (hmb), which is characterized by necrotic skin react ... | 2016 | 27177994 |
| evaluation of a transcription mediated amplification assay for detection of herpes simplex virus types 1 and 2 mrna in clinical specimens. | herpes simplex viruses (hsv) are double-stranded dna human herpesviruses (hhvs) that have the capacity to cause significant morbidity and mortality in humans. like hhv5 (cytomegalovirus) and hhv8 (kaposi's sarcoma virus), hsv type 1 (hsv-1), and hsv type 2 (hsv-2) (hhv1, hhv2) selectively package certain viral messenger rnas inside mature virions, as well as expressing those mrnas in infected cells. | 2016 | 27175478 |
| chronic physical stress does not interact with epstein-barr virus (ebv)-encoded dutpase to alter the sickness response. | most adult humans have been infected with epstein-barr virus (ebv), which is thought to contribute to the development of chronic fatigue syndrome. stress is known to influence the immune system and can exacerbate the sickness response. although a role for psychological stress in the sickness response, particularly in combination with ebv-encoded deoxyuridine triphosphate nucleotidohydrolase (dutpase) has been established, and the role of physical stressors in these interactions remains unspecifi ... | 2015 | 27175311 |
| viral infections in patients with hematological malignancies. | viral infections remain one of the most frequent complications in patients with hematological malignancies, especially in those receiving an allogeneic stem cell transplantation. viral infections result from reactivation of latent infection rather than from acquisition of new infection. infections caused by herpes viruses, including cytomegalovirus and epstein-barr virus, respiratory viruses and hepatitis b virus are frequently associated with high morbidity and mortality in the immunocompromise ... | 2012 | 27175238 |
| immune-checkpoint expression in epstein-barr virus positive and negative plasmablastic lymphoma: a clinical and pathological study in 82 patients. | plasmablastic lymphoma is a rare and aggressive diffuse large b-cell lymphoma commonly associated with epstein-barr virus co-infection that most often occurs in the context of human immunodeficiency virus infection. therefore, its immune escape strategy may involve the upregulation of immune-checkpoint proteins allowing the tumor immune evasion. however, the expression of these molecules was poorly studied in this lymphoma. we have investigated 82 plasmablastic lymphoma cases of whom half were e ... | 2016 | 27175027 |
| epstein-barr virus-positive diffuse large b cell lymphoma arising from a chronic lymphocytic leukemia: overlapping features with classical hodgkin lymphoma. | a small proportion of patients with chronic lymphocytic leukemia (cll) may progress to large cell lymphoma, or richter syndrome (rs). the large cells of rs may arise through transformation of the original cll clone (clonally related) or represent a new neoplasm (clonally unrelated), which might be epstein-barr virus (ebv)-associated. we present a 61-year-old male with 5-year history of cll who developed rs on bilateral adrenal glands. the tumor showed a vague nodular growth pattern separated by ... | 2016 | 27170210 |
| association of gata2 deficiency with severe primary epstein-barr virus (ebv) infection and ebv-associated cancers. | most patients infected with epstein-barr virus (ebv) are asymptomatic, have nonspecific symptoms, or have self-limiting infectious mononucleosis. ebv, however, may result in severe primary disease or cancer. | 2016 | 27169477 |
| [discordant lymphoma of duodenal ebv-positive peripheral t-cell lymphoma not otherwise specified and ileal diffuse large b-cell lymphoma]. | a 79-year-old woman was admitted with a 5-kg weight loss and anorexia. computed tomography showed diffuse lymphadenopathy, and thickening of the duodenal and ileal walls. the patient then underwent biopsy of these sites. pathological examination revealed duodenal epstein-barr virus (ebv)-positive peripheral t cell lymphoma-not otherwise specified (ptcl-nos) and ebv-negative ileal diffuse large b-cell lymphoma (dlbcl) to be present simultaneously. combination chemotherapy including rituximab prod ... | 2016 | 27169448 |
| an unusual case of anaplastic lymphoma kinase-positive large b-cell lymphoma in an elderly patient: a case report and discussion. | we present an unusual case of anaplastic lymphoma kinase (alk)-positive large b-cell lymphoma, with rapid clinical progression, which occurred in a 90-year-old male patient. the patient presented with numerous enlarged lymph nodes in the neck and mediastinum. histopathological analysis of a single lymph node detected diffuse large immunoblastic- or plasmablastic-like tumor cells, which were strongly immunoreactive for alk in a granular cytoplasmic distribution, but negative for the expression of ... | 2016 | 27168806 |
| epstein-barr virus encoded mir-bart11 promotes inflammation-induced carcinogenesis by targeting foxp1. | epstein-barr virus (ebv) infection and chronic inflammation are closely associated with the development and progression of nasopharyngeal carcinoma (npc) and gastric cancer (gc), and the infiltration of inflammatory cells, including tumor-associated macrophages (tams), is often observed in these cancers. ebv encodes 44 mature micro rnas (mirnas), but the roles of only a few ebv-encoded mirna targets are known in cancer development, and here, our aim was to elucidate the effects of ebv-mir-bart11 ... | 2016 | 27167345 |
| clinical presentation of hemophagocytic lymphohistiocytosis in adults is less typical than in children. | hemophagocytic lymphohistiocytosis in adults is largely underdiagnosed. to improve the rate and accuracy of diagnosis in adults, the clinical and laboratory characteristics of hemophagocytic lymphohistiocytosis were analyzed in and compared between adults and children in a chinese cohort. | 2016 | 27166770 |
| monitoring of epstein-barr virus load and killer t cells in patients with juvenile idiopathic arthritis treated with methotrexate or tocilizumab. | methotrexate (mtx) is used for the treatment of polyarticular juvenile idiopathic arthritis (jia), and an anti-interleukin-6 receptor monoclonal antibody (tocilizumab: tcz) is also used and added for the treatment of intractable jia. it has been reported that mtx might induce epstein-barr virus (ebv)-associated lymphoma, but the discussion about the effect of mtx and/or tcz against reactivation of ebv in pediatric patients has been incomplete. | 2017 | 27166661 |
| frequency of epstein - barr virus in patients presenting with acute febrile illness in kenya. | most acute febrile illnesses (afi) are usually not associated with a specific diagnosis because of limitations of available diagnostics. this study reports on the frequency of ebv viremia and viral load in children and adults presenting with febrile illness in hospitals in kenya. | 2016 | 27163791 |
| successful curative therapy with rituximab and allogeneic haematopoietic stem cell transplantation for malt lymphoma associated with stk4-mutated cd4+ lymphocytopenia. | idiopathic cd4+ lymphocytopenia and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (malt lymphoma) are rare diseases in children. we report the first case of a child with stk4-mutated cd4+ lymphocytopenia who developed epstein-barr virus associated malt lymphoma arising in the salivary gland. the child achieved complete remission with rituximab, and her immunodeficiency was cured by haematopoietic stem cell transplantation. the child remained well 24 months post transplan ... | 2016 | 27163767 |
| distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma. | nasopharyngeal carcinoma is one of the leading malignancies with obscure etiology. circulating tumor cells have been showed to intimately correlate with characteristics in different kinds of cancer. but links between circulating tumor cells and nasopharyngeal carcinoma were still lacking. therefore, we explored circulating tumor cells' distribution in nasopharyngeal carcinoma and their possible associations with nasopharyngeal carcinoma. | 2016 | 27162320 |
| [pharmacological correction of metabolic disorders in children with acute epstein--barr viral infection]. | the study was aimed to investigate the influence of drug reamberin inclusion in the treatment regimen of patients with acute epstein-barr virus (ebv) infection on the effectiveness of therapy. treatment results were analyzed in a group of 70 children aged 4-15 with a diagnosis of moderate to severe ebv infection. by the method of random sampling distribution, patients were divided into two comparable groups of 35 children, which were representative with respect to gender, age, date of admission, ... | 2016 | 27159955 |
| spleen histologic appearance in common variable immunodeficiency: analysis of 17 cases. | histologic and phenotypic analyses of splenectomy samples from 17 patients with common variable immunodeficiency (cvid) showed the following nonspecific, evocative, white-pulp lesions: white-pulp hyperplasia (wph) with reactive follicles, giant follicles (gfs), marginal zone hyperplasia, periarteriolar t-zone hyperplasia (path) and/or granulomas, which enabled us to discern 2 groups: the first (n=6) composed of wph with reactive follicles without granulomas, and the second (n=9) characterized by ... | 2016 | 27158760 |
| epstein-barr virus associated multi-organ smooth muscle tumours following renal transplantation. | 2016 | 27158124 | |
| comparative evaluation of four real-time pcr methods for the quantitative detection of epstein-barr virus from whole blood specimens. | monitoring of epstein-barr virus (ebv) load in immunocompromised patients has become integral to their care. an increasing number of reagents are available for quantitative detection of ebv; however, there are little published comparative data. four real-time pcr systems (one using laboratory-developed reagents and three using analyte-specific reagents) were compared with one another for detection of ebv from whole blood. whole blood specimens seeded with ebv were used to determine quantitative ... | 2016 | 27157323 |
| clinicopathological categorization of epstein-barr virus-positive t/nk-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications. | epstein-barr virus-positive t/nk-cell lymphoproliferative diseases (ebv-t/nk-lpds) include several overlapping ebv-related conditions with variably aggressive courses. for prognostic categorization, we retrospectively analyzed 42 ebv-t/nk-lpd cases. male (79% [33/42]), young (≤40 years; 83% [35/42]) patients and t-cell lineage (81% [34/42]; cd8/cd4 = 1.8) were predominant. clinicopathologically, three systemic and one cutaneous category were developed: hemophagocytic lymphohistiocytosis (hlh; 26 ... | 2017 | 27157296 |
| epstein-barr virus load in transplant patients: early detection of post-transplant lymphoproliferative disorders. | high levels of circulating ebv load are used as a marker of post-transplant lymphoproliferative disorders (ptld). there is no consensus regarding the threshold level indicative of an increase in peripheral ebv dna. the aim of the study was to clinically validate a developed ebv quantification assay for early ptld detection. transversal study: paired peripheral blood mononuclear cells (pbmc), plasma and oropharyngeal lymphoid tissue (olt) from children undergoing a solid organ transplant with (n= ... | 2017 | 27157146 |
| multivariate eqtl mapping uncovers functional variation on the x-chromosome associated with complex disease traits. | very few studies have investigated the associations between genetic polymorphisms and gene expression on the x-chromosome. this is a major bottleneck when conducting functional follow-up studies of trait-associated variants, as those identified in genome-wide association studies (gwas). we used a multivariate approach to test the association between individual single nucleotide polymorphisms (snps) and exon expression levels measured in 356 epstein-barr virus-transformed lymphoblastoid cell line ... | 2016 | 27155841 |
| a novel, rapid and efficient method of cloning functional antigen-specific t-cell receptors from single human and mouse t-cells. | t-cell receptor (tcr) gene therapy is a promising approach for the treatment of infectious diseases and cancers. however, the paired cloning and functional assays of antigen-specific tcrα and tcrβ is time-consuming and laborious. in this study, we developed a novel, rapid and efficient antigen-specific tcr-cloning system by combining three technologies: multiplex one-step rt-pcr, transcriptionally active pcr (tap) and luciferase reporter assays. multiplex one-step rt-pcr with leader primers desi ... | 2016 | 27155153 |
| the microenvironment of classical hodgkin lymphoma: heterogeneity by epstein-barr virus presence and location within the tumor. | 2016 | 27152844 | |
| cutaneous extranodal natural killer/t-cell lymphomas histopathologically mimicking benign inflammatory disease. | few studies have evaluated the histopathological features of cutaneous extranodal nk/t-cell lymphoma (enktl). the authors' study aims to describe cases of cutaneous enktl that histopathologically mimic benign inflammatory dermatosis. the authors searched the database of asan medical center to identify cases of cutaneous enktl that were confirmed by skin biopsy between january 1998 and december 2014. the authors included cases that were initially diagnosed as benign inflammatory disorders on the ... | 2017 | 27149332 |
| concomitant presentation of hemophagocytic lymphohistiocytosis and posttransplant lymphoproliferative disease-like lymphoma in a mildly immunosuppressed leukemia patient: an unusual association. | we describe a 4-year-old female with pre-b-cell acute lymphoblastic leukemia on maintenance chemotherapy, who developed hemophagocytic lymphohistiocytosis (hlh) secondary to epstein-barr virus (ebv) infection, complicated by an aggressive lymphoproliferative disorder. although there was no history of bone marrow transplant or underlying immunodeficiency, ebv triggered a post-transplant lymphoproliferative disease (ptld)-like lymphoma. multiple regimens of chemotherapy failed to induce remission ... | 2016 | 27148941 |
| methotrexate in crohn's disease: a new face for an old drug? | methotrexate is commonly used in rheumatoid arthritis but randomised controlled trials demonstrated its efficacy also in crohn's disease. methotrexate, although marginally used in clinical practice, is considered an appropriate immunomodulator particularly in patients refractory or intolerant to thiopurines. areas covered: a literature search using 'methotrexate', 'crohn's disease' and 'inflammatory bowel disease' as key words, identified randomised controlled trials, meta-analyses and observati ... | 2016 | 27148828 |
| nf-κb signaling regulates expression of epstein-barr virus bart micrornas and long noncoding rnas in nasopharyngeal carcinoma. | epstein-barr virus (ebv) expresses few viral proteins in nasopharyngeal carcinoma (npc) but high levels of bamhi-a rightward transcripts (barts), which include long noncoding rnas (lncrnas) and bart micrornas (mirnas). it is hypothesized that the mechanism for regulation of barts may relate to ebv pathogenesis in npc. we showed that nuclear factor-κb (nf-κb) activates the bart promoters and modulates the expression of barts in ebv-infected npc cells but that introduction of mutations into the pu ... | 2016 | 27147748 |
| abundant pd-l1 expression in epstein-barr virus-infected gastric cancers. | gastric cancer (gc) is a deadly disease with limited treatment options. recent studies with pd-1 inhibition have shown promising results in gc, but key questions remain regarding which gc subclass may respond best. in other cancers, expression of the pd-1 ligand pd-l1 has been shown to identify cancers with greater likelihood of response to pd-1 blockade. we here show with immunohistochemistry that epstein-barr virus (ebv)+ gcs (n = 32) have robust pd-l1 expression not seen in other gcs. in ebv+ ... | 2016 | 27147580 |
| pembrolizumab in classical hodgkin's lymphoma. | pembrolizumab is a humanized monoclonal antibody directed against programmed cell death protein 1 (pd-1), a key immune-inhibitory molecule expressed on t cells and implicated in cd4+ t-cell exhaustion and tumor immune-escape mechanisms. classical hodgkin's lymphoma (chl) is a unique b-cell malignancy in the sense that malignant reed-sternberg (rs) cells represent a small percentage of cells within an extensive immune cell infiltrate. pd-1 ligands are upregulated on rs cells as a consequence of b ... | 2016 | 27147112 |
| genomic variation of epstein-barr virus in inflammatory pseudotumour-like follicular dendritic cell tumour. | 2016 | 27146079 | |
| comprehensive profiling of virus micrornas of epstein-barr virus-associated gastric carcinoma: highlighting the interactions of ebv-bart9 and host tumor cells. | epstein-barr virus (ebv) is suggested to actively utilize its ebv-micrornas (mirnas) to manipulate viral and cellular functions during neoplasia transformation. a systemic profiling of ebv-mirnas expressed in ebv-associated gastric carcinoma (ebva gc) helps understand its epigenetic regulation of carcinogenesis. | 2017 | 27144885 |
| small-cell predominant extranodal nk/t cell lymphoma, nasal type: clinicopathological analysis of a series of cases diagnosed in a western population. | extranodal nk/t cell lymphoma, nasal type (enktcl) is usually composed of medium- to large-sized lymphoid cells showing prominent angiotrophism and tumour cell necrosis. we report 13 cases composed predominantly of small lymphocytes diagnosed in the united states and western europe. | 2016 | 27144366 |
| the role of epstein-barr virus dna load and serology as screening tools for nasopharyngeal carcinoma. | screening for nasopharyngeal carcinoma (npc) among family members has been advocated in endemic populations in view of significantly increased risks. we aimed to compare the role of epstein-barr virus (ebv) dna load and ebv iga serology as tools for screening patients with a first-degree family history of npc. | 2016 | 27143706 |