Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| the asexual yeast candida glabrata maintains distinct a and alpha haploid mating types. | the genome of the type strain of candida glabrata (cbs138, atcc 2001) contains homologs of most of the genes involved in mating in saccharomyces cerevisiae, starting with the mating pheromone and receptor genes. only haploid cells are ever isolated, but c. glabrata strains of both mating types are commonly found, the type strain being mat alpha and most other strains, such as bg2, being mata. no sexual cycle has been documented for this species. in order to understand which steps of the mating p ... | 2008 | 18375614 |
| [candidemia in a brazilian tertiary care hospital: incidence, frequency of different species, risk factors and antifungal susceptibility]. | results from a cross-sectional observational study on candidemia conducted at hospital de clínicas, federal university of paraná, are presented. from january 2001 to december 2004, one hundred candidemia cases were evaluated. the incidence was 1.27 episodes per 1,000 hospitalizations and candida was the eighth most frequently isolated agent from bloodstream infections. the patients ages ranged from five days to 89 years, with a mean of 32 years. sixty percent of the cases occurred in adults (66% ... | 2008 | 18368266 |
| identification and differentiation of candida species from pediatric patients by random amplified polymorphic dna. | thirty-four candida isolates were analyzed by random amplified polymorphic dna using the primer opg-10:24 candida albicans; 4 candida tropicalis; 2 candida parapsilosis; 2 candida dubliniensis; 1 candida glabrata and 1 candida krusei. the upgma-pearson correlation coefficient was used to calculate the genetic distance between the different candida groupings. samples were classified as identical (correlation of 100%); highly related samples (90%); moderately related samples (80%) and unrelated sa ... | 2008 | 18368262 |
| functional characterization of the cgpgs1 gene reveals a link between mitochondrial phospholipid homeostasis and drug resistance in candida glabrata. | cardiolipin and its precursor phosphatidylglycerol are two anionic phospholipids that are essential for the biogenesis of functional mitochondria. to assess their role in mitochondrial and cellular functions in the pathogenic yeast candida glabrata, a functional characterization of the cgpgs1 gene encoding the phosphatidylglycerolphosphate synthase has been carried out. transposon insertion mutation in cgpgs1 resulted in the loss of phosphatidylglycerolphosphate synthase activity and in deficien ... | 2008 | 18343926 |
| comparative evaluation of atb fungus 2 and sensititre yeastone panels for testing in vitro candida antifungal susceptibility. | atb fungus 2 and sensititreyeastone are commercial methods for antifungal susceptibility testing of yeasts. the agreement between these two methods was assessed with a total of 133 candida strains (60 candida albicans, 18 candida dubliniensis, 29 candida glabrata, and 26 candida krusei). mic endpoints were established after 24 h of incubation at 36-/+1 degrees c by each method. intra-laboratory reproducibility of both methods was excellent (=or>99%). overall agreement between atb fungus 2 and se ... | 2008 | 18338919 |
| the conserved pa14 domain of cell wall-associated fungal adhesins governs their glycan-binding specificity. | yeast cell wall-associated, lectin-like adhesins form large families that mediate flocculation and host cell recognition. the glycan specificity of individual adhesins is largely unknown. zupancic et al. (this issue of molecular microbiology) used glycan microarrays to compare the glycan-binding characteristics of individual adhesins (epa proteins) of the pathogenic yeast candida glabrata produced in the non-adherent yeast saccharomyces cerevisiae. by sequence swapping between the conserved pa14 ... | 2008 | 18331471 |
| antifungal susceptibility testing of micafungin against candida glabrata isolates. | antifungal susceptibility of micafungin against isolates of c. glabrata was performed to evaluate the hypothesis that micafungin may be a suitable alternative in treating those patients whose infections are from c. glabrata and have developed resistance to fluconazole. | 2008 | 18329581 |
| bile aspiration for diagnosis of candida glabrata cholecystitis. | 2008 | 18327680 | |
| fournier's gangrene due to candida glabrata. | fournier's gangrene is a rare and serious event. usual pathogens are bacteria of the skin and the digestive tract. candida species are exceptionally involved, mostly candida albicans. we report a patient with non-c. albicans candida sp. fournier's gangrene who survived with an appropriate antifungal therapy. yeasts should be considered as emerging pathogens in pelvic infections due to the increase in long-term immunocompromised patients. | 2008 | 18324496 |
| the atp-binding cassette transporter-encoding gene cgsnq2 is contributing to the cgpdr1-dependent azole resistance of candida glabrata. | our previous investigation on candida glabrata azole-resistant isolates identified two isolates with unaltered expression of cgcdr1/cgcdr2, but with upregulation of another atp-binding cassette transporter, cgsnq2, which is a gene highly similar to scsnq2 from saccharomyces cerevisiae. one of the two isolates (bpy55) was used here to elucidate this phenomenon. disruption of cgsnq2 in bpy55 decreased azole resistance, whereas reintroduction of the gene in a cgsnq2 deletion mutant fully reversed t ... | 2008 | 18312269 |
| flavour formation in fungi: characterisation of klatf, the kluyveromyces lactis orthologue of the saccharomyces cerevisiae alcohol acetyltransferases atf1 and atf2. | volatile aroma-active esters are responsible for the fruity character of fermented alcoholic beverages, such as beer and wine. in the brewers' yeast saccharomyces cerevisiae, the major part of these esters is formed by two alcohol acetyltransferases, atf1 and atf2. in this paper, the existence of orthologues of these s. cerevisiae alcohol acetyltransferases in several ascomycetous fungi was investigated. bioinformatic analysis of sequenced fungal genomes revealed the presence of multiple ortholo ... | 2008 | 18309479 |
| susceptibilities to amphotericin b and fluconazole of candida species in taiwan surveillance of antimicrobial resistance of yeasts 2006. | susceptibilities to amphotericin b and fluconazole of 964 candida isolates collected in taiwan surveillance of antimicrobial resistance of yeasts in 2006 were determined. there were 419 (43.5%) candida albicans, 246 (25.5%) candida tropicalis, 211 (21.9%) candida glabrata, 62 (6.4%) candida parapsilosis, 14 (1.5%) candida krusei, and 12 (1.2%) others. interestingly, 16 of the 17 amphotericin b-resistant isolates were non-albicans candida species. the resistant rate to amphotericin b has decrease ... | 2008 | 18304773 |
| efungumab and caspofungin: pre-clinical data supporting synergy. | heat shock protein 90 (hsp90) is targeted by the humoral response in invasive candidiasis. this paper tests for synergy between caspofungin and efungumab--a human antibody fragment against hsp90. | 2008 | 18299636 |
| semi-national surveillance of fungaemia in denmark 2004-2006: increasing incidence of fungaemia and numbers of isolates with reduced azole susceptibility. | a semi-national laboratory-based surveillance programme for fungaemia was initiated in 2003 that now covers c. 3.5 million inhabitants (64%) of the danish population. in total, 1089 episodes of fungaemia were recorded during 2004-2006, corresponding to an annual incidence of 10.4/100 000 inhabitants. the annual number of episodes increased by 17% during the study period. candida spp. accounted for 98% of the fungal pathogens. although candida albicans remained predominant, the proportion of c. a ... | 2008 | 18294241 |
| absence of amphotericin b-tolerant persister cells in biofilms of some candida species. | biofilms and planktonic cells of five candida species were surveyed for the presence of persister (drug-tolerant) cell populations after exposure to amphotericin b. none of the planktonic cultures (exponential or stationary phase) contained persister cells. however, persisters were found in biofilms of one of two strains of candida albicans tested and in biofilms of candida krusei and candida parapsilosis, but not in biofilms of candida glabrata or candida tropicalis. these results suggest that ... | 2008 | 18285487 |
| molecular identification of candida orthopsilosis isolated from blood culture. | the incidence of candidemia and invasive candidiasis have increased markedly due to the increasing number of immunocompromised patients. there are five major medically important species of candida with their frequency of isolation in the diminishing order namely candida albicans, candida parapsilosis, candida tropicalis, candida glabrata and candida krusei. in addition, there are numerous other species of candida which differ in their genetic makeup, virulence properties, drug susceptibilities a ... | 2008 | 18266075 |
| a prospective clinical trial of a real-time polymerase chain reaction assay for the diagnosis of candidemia in nonneutropenic, critically ill adults. | invasive candida infection among nonneutropenic, critically ill adults is a clinical problem that has received increasing attention in recent years. poor performance of extant diagnostic modalities has promoted risk-based, preemptive prescribing in view of the poor outcomes associated with inadequate or delayed antifungal therapy; this risks unnecessary overtreatment. a rapid, reliable diagnostic test could have a substantial impact on therapeutic practice in this patient population. | 2008 | 18260751 |
| efficacy of a new formulation of amphotericin b in a murine model of disseminated infection by candida glabrata. | amphotericin b poly-aggregates are a new formulation of amphotericin b, which can be obtained cheaply. in this study, we tested the efficacy of this new formulation for treating a disseminated infection by candida glabrata in a murine model. | 2008 | 18256113 |
| primary isolation of candida species from urine specimens using chromogenic medium. | chromagar candida (cac) is a chromogenic medium that can be used to detect candida species, including candida albicans, candida krusei, candida tropicalis, and perhaps candida glabrata. we evaluated the utility of cac to detect candiduria in high-risk patients and the potential usefulness of this information in directing initial antifungal therapy in those later identified with candidaemia. cac was compared in parallel to standard laboratory methods (sm) for the detection of candida from urine c ... | 2008 | 18254751 |
| [psoas abscess of the adult: study of 38 cases]. | our aim is to report the clinical aspects, the etiologies, the treatment and the evolution of the psoas abscess in the adult. | 2007 | 18254281 |
| respiratory deficiency enhances the sensitivity of the pathogenic fungus candida to photodynamic treatment. | mucosal infections caused by the pathogenic fungus candida are a significant infectious disease problem and are often difficult to eradicate because of the high frequency of resistance to conventional antifungal agents. photodynamic treatment (pdt) offers an attractive therapeutic alternative. previous studies demonstrated that filamentous forms and biofilms of candida albicans were sensitive to pdt using photofrin as a photosensitizer. however, early stationary phase yeast forms of c. albicans ... | 2008 | 18248505 |
| successful treatment of prosthetic knee candida glabrata infection with caspofungin combined with flucytosine. | 2008 | 18242959 | |
| successful treatment of encapsulating peritoneal sclerosis with immunosuppressive therapy. | encapsulating peritoneal sclerosis is a rare, but potentially lethal, complication of peritoneal dialysis. treatment of patients with encapsulating peritoneal sclerosis is controversial. conservative treatment carries a poor outcome, and immunosuppressive drugs are now used frequently. most commonly, these immunosuppressive regimens include steroids with or without azathioprine or cyclosporine. mycophenolate mofetil is a reversible dna synthesis inhibitor that frequently replaces azathioprine in ... | 2008 | 18215692 |
| a pharmacokinetic/pharmacodynamic mathematical model accurately describes the activity of voriconazole against candida spp. in vitro. | we developed a pharmacokinetic/pharmacodynamic (pk/pd) mathematical model that fits voriconazole time-kill data against candida isolates in vitro and used the model to simulate the expected kill curves for typical intravenous and oral dosing regimens. a series of emax mathematical models were used to fit time-kill data for two isolates each of candida albicans, candida glabrata and candida parapsilosis. pk parameters extracted from human data sets were used in the model to simulate kill curves f ... | 2008 | 18215509 |
| candida nivariensis, an emerging pathogenic fungus with multidrug resistance to antifungal agents. | in 2005, candida nivariensis, a yeast species genetically related to candida glabrata, was described following its isolation from three patients in a single spanish hospital. between 2005 and 2006, 16 fungal isolates with phenotypic similarities to c. nivariensis were submitted to the united kingdom mycology reference laboratory for identification. the strains originated from various clinical specimens, including deep, usually sterile sites, from patients at 12 different hospitals in the united ... | 2008 | 18199788 |
| synthesis and in vitro biological properties of novel cationic derivatives of amphotericin b. | novel cationic amphotericin b derivatives as highly potent antifungal agents are reported. these semi-synthetic derivatives of amphotericin b were elaborated through a series of modifications both on the nitrogen atom of the mycosamine and on the c-16 carboxylic acid moiety. the antifungal activity of the new conjugates was tested against saccharomyces cerevisiae and also against nine different strains of candida albicans and candida glabrata, including an amphotericin resistant strain. high pot ... | 2008 | 18196508 |
| proteomic analysis of the ph response in the fungal pathogen candida glabrata. | micro-organisms must adapt to environmental change to survive, and this is particularly true for fungal pathogens such as candida glabrata. c. glabrata is found both in the environment and in diverse niches in its human host. the ambient ph of these niches varies considerably, and therefore we have examined the response of c. glabrata to changes in ambient ph using a proteomic approach. proteins expressed in c. glabrata cells growing at ph 4.0, 7.4 or 8.0 were compared by 2-de, and 174 spots dis ... | 2008 | 18186024 |
| kininogen adsorption to the cell surface of candida spp. | the invasion of human host by pathogenic microorganisms is often associated with increased kinin production which may occur due to the action of pathogen secretory proteinases or the activation of host's surface-dependent kinin generation cascade, initiated by the adsorption of high molecular weight kininogen (hk) on the pathogen cells. in this work we characterize for the first time the binding of hk by candida yeasts and analyze this adsorption in terms of intraspecific variation and a depende ... | 2008 | 18182233 |
| oral carriage of yeasts and coliforms in stroke sufferers: a prospective longitudinal study. | to investigate prospectively the qualitative and quantitative changes in oral carriage of yeasts and coliforms in southern chinese people suffering from stroke. | 2008 | 18173450 |
| antifungal effect of high- and low-molecular-weight chitosan hydrochloride, carboxymethyl chitosan, chitosan oligosaccharide and n-acetyl-d-glucosamine against candida albicans, candida krusei and candida glabrata. | generally, chitosan is a water-insoluble polyaminosaccharide with antimicrobial activity. the antifungal activity of water-soluble low- and high-molecular-weight chitosan hydrochloride, carboxymethyl chitosan, chitosan oligosaccharide and n-acetyl-d-glucosamine against candida albicans, candida krusei and candida glabrata was investigated. | 2008 | 18164151 |
| dna microarray based on arrayed-primer extension technique for identification of pathogenic fungi responsible for invasive and superficial mycoses. | an oligonucleotide microarray based on the arrayed-primer extension (apex) technique has been developed to simultaneously identify pathogenic fungi frequently isolated from invasive and superficial infections. species-specific oligonucleotide probes complementary to the internal transcribed spacer 1 and 2 (its1 and its2) region were designed for 24 species belonging to 10 genera, including candida species (candida albicans, candida dubliniensis, candida famata, candida glabrata, candida tropical ... | 2008 | 18160452 |
| early clinical experience with anidulafungin at a large tertiary care medical center. | to evaluate early clinical experience with anidulafungin. | 2008 | 18154476 |
| membrane structure and interactions of a short lycotoxin i analogue. | lycotoxin i and lycotoxin ii are natural anti-microbial peptides that were identified in the venom of the wolf spider lycosa carolinensis. these peptides were found to be potent growth inhibitors for bacteria (escherichia coli) and yeast (candida glabrata) at micromolar concentrations. recently, shortened analogues of lycoi and lycoii have been reported to have decreased haemolytic effects. a shorter lyco-i analogue studied, lycoi 1-15 (h-iwltalkflgkhaak-nh2), was active only above 10 microm, bu ... | 2008 | 18098329 |
| [identification and susceptibility against fluconazole and albaconazole of 100 yeasts' strains isolated from vaginal discharge]. | vulvovaginal candidiasis is a condition that affects a great number of fertile women. it is considered the second cause of genital infection after vaginosis due to gam complex. candida albicans is the most frequent isolated species from vaginal discharge. however, sometimes more than one yeast species could be found in the same clinical sample that are more resistant to antifungal drugs. nowadays, it is necessary to identify properly up to species level the isolated microorganism and to determin ... | 2007 | 18095765 |
| increases in slt2 expression and chitin content are associated with incomplete killing of candida glabrata by caspofungin. | incomplete killing was observed for caspofungin against candida glabrata, which was associated with increased slt2 expression and elevated chitin content. in contrast, fungicidal activity and no chitin increase were observed in an isogenic delta slt2 strain, suggesting a role for slt2 and chitin production in the response of c. glabrata to caspofungin. | 2008 | 18086838 |
| increasing incidence of candida parapsilosis candidemia with caspofungin usage. | to determine the impact on the change in epidemiology of candida species at our institution since the introduction of caspofungin. | 2008 | 18082269 |
| complete mitochondrial genome sequence of the wine yeast candida zemplinina: intraspecies distribution of a novel group-iib1 intron with eubacterial affiliations. | the mtdna of the ascomycetous wine yeast candida zemplinina is a circularly mapping genome of 23,114 bp. it contains 35 genes coding for the seven basic subunits of oxidative phosporylation found in yeasts (the genes encoding for nadh oxidoreductase subunits are absent), the ribosomal protein var1, two rrnas and 25 trna genes. although protein phylogenetic analysis showed a divergent mitochondrial genome, several traits appeared preserved. the conserved gene blocks between the mtdnas of c. zempl ... | 2008 | 18081838 |
| candida bracarensis detected among isolates of candida glabrata by peptide nucleic acid fluorescence in situ hybridization: susceptibility data and documentation of presumed infection. | molecular taxonomic studies have revealed new candida species among phenotypically delineated species, the best example being candida dubliniensis. this study was designed to determine the occurrence of two new molecularly defined species, candida bracarensis and candida nivariensis, which are closely related to and identified as candida glabrata by phenotypic assays. a total of 137 recent clinical isolates of c. glabrata identified by phenotypic characteristics was tested with c. bracarensis an ... | 2008 | 18077641 |
| molecular epidemiology of candida species isolated from clinical specimens of intensive care unit patients. | epidemiological analysis of nosocomial candida infections has gained importance due to an increase in these infections during the recent years. this study investigated the prevalence of clinical infections of candida in anesthesiology intensive care unit patients, and ascertains the level of genetic diversity in the candida species. a total of 70 candida isolates, consisting of 42 candida albicans, 16 candida glabrata and 12 candida tropicalis strains isolated from various clinical sites of infe ... | 2008 | 18076594 |
| potent anti-microbial activity of traditional chinese medicine herbs against candida species. | anti-candidial activities of eight traditional chinese medicinal (tcm) herbs were evaluated against six different candida species. tcm preparations were screened for antifungal activity using a standard agar diffusion assay. following identification of potential candidate herbs, their minimum inhibitory concentration (mic) values were determined using the standardised nccls m-27a broth microdilution assay. among tcm herbs, rhizoma coptidis had potent antifungal activity against candida glabrata, ... | 2008 | 18076592 |
| in vivo pharmacodynamic characterization of anidulafungin in a neutropenic murine candidiasis model. | multiple in vivo studies have characterized the pharmacodynamics of drugs from the triazole and polyene antifungal drug classes. fewer studies have investigated these pharmacodynamic relationships for the echinocandin drug class. we used a neutropenic murine model of disseminated candida albicans, candida tropicalis, and candida glabrata infection to characterize the time course of activity of the new echinocandin anidulafungin. the pharmacokinetic-pharmacodynamic (pk-pd) indices (the percentage ... | 2008 | 18070979 |
| comparative in vitro activities of caspofungin and micafungin, determined using the method of the european committee on antimicrobial susceptibility testing, against yeast isolates obtained in france in 2005-2006. | the in vitro activities of caspofungin and micafungin against 1,038 yeast isolates have been determined. the caspofungin and micafungin mics were lower for candida albicans, candida glabrata, and candida tropicalis than for candida parapsilosis, candida guilliermondii, and candida krusei. a clear correlation was seen between the mics for the two drugs. | 2008 | 18070978 |
| antifungal susceptibility of bloodstream yeasts isolated at a public children's hospital in brazil: comparison of the etest and the afst-eucast microdilution method. | this study compared the minimum inhibitory concentration (mic) results from the proposed standard methods of the antifungal susceptibility testing subcommittee of the european committee on antibiotic susceptibility testing (afst-eucast) with the commercial system etest(r) in the evaluation of susceptibility to flucytosine, fluconazole, itraconazole, voriconazole, and amphotericin b of 136 candida spp. isolated from the blood of hospitalized children. the results presented a greater agreement amo ... | 2007 | 18059562 |
| fluconazole prophylaxis against fungal colonization and invasive fungal infection in very low birth weight infants. | fungal infections are common cause of morbidity and mortality in very low birth weight infants | 2007 | 18057479 |
| posaconazole activity against candida glabrata after exposure to caspofungin or amphotericin b. | we evaluated the effects of sequential therapy with caspofungin (cas) or amphotericin b (amb) followed by posaconazole (pos) against candida glabrata. the susceptibilities to pos of yeast cells pre-exposed to cas or amb were identical to those of untreated cells as shown by standard clinical and laboratory standards institute broth dilution, cell viability, and disk diffusion methods. we then investigated the activity of sequential regimens in an experimental model of disseminated candidiasis. c ... | 2008 | 18056279 |
| activities of fluconazole and voriconazole against bloodstream isolates of candida glabrata and candida krusei: a 14-year study in a spanish tertiary medical centre. | the aim of this study was to evaluate the in vitro activities of voriconazole and fluconazole against candida glabrata and candida krusei isolated from blood during a 14-year period (1990-2003) at the tertiary care hospital of cruces (barakaldo, spain). the in vitro activities of fluconazole and voriconazole against 28 isolates of c. glabrata and 15 isolates of c. krusei were determined by the clinical and laboratory standards institute disk diffusion method. of the 28 c. glabrata isolates teste ... | 2008 | 18054468 |
| candida glabrata fungaemia in intensive care units. | candidaemia is increasingly important in intensive care units (icus). compared with candida albicans fungaemia, the impact of c. glabrata fungaemia on icu patients is not well-known. the aim of this study was to investigate the clinical features, the antifungal susceptibility and the treatment outcomes of c. glabrata fungaemia in icu patients. the medical records of icu patients with candidaemia between 2000 and 2005 were reviewed retrospectively, and antifungal susceptibility testing was perfor ... | 2008 | 18042196 |
| caspofungin as primary antifungal prophylaxis in stem cell transplant recipients. | to assess the effectiveness and tolerability of caspofungin as primary prophylaxis against invasive fungal infections in stem cell transplant recipients who are poor candidates for triazole or lipid amphotericin b prophylaxis due to renal or hepatic dysfunction, and to determine whether any patient characteristics are independently associated with an increased risk of breakthrough invasive fungal infection during caspofungin prophylaxis. | 2007 | 18041885 |
| prevalence & susceptibility to fluconazole of candida species causing vulvovaginitis. | vulvovaginal candidiasis is an important cause of morbidity in women of reproductive age. this study was carried out to determine the species prevalence and susceptibility pattern to fluconazole of yeasts isolated from the vagina of symptomatic women. | 2007 | 18037716 |
| synthesis of new isoxazoles and dihydroisoxazoles and in vitro evaluation of their antifungal activity. | new 2-(2,4-dihalogenophenyl)-1-(1h-imidazol-1-yl)-3-(isoxazol-5-yl)propan-2-ols and 2-(2,4-dihalogenophenyl)-1-(1h-imidazol-1-yl)-3-(4,5-dihydroisoxazol-5-yl)propan-2-ols were synthesized by 1,3-dipolar cycloaddition between homopropargylic or homoallylic alcohols and in-situ generated nitrile oxide. their antifungal activity was evaluated against candida albicans, c. glabrata, aspergillus fumigatus and an azole-resistant petite mutant of c. glabrata. preliminary sar results are discussed. | 2007 | 18035824 |
| rapid identification of candida glabrata in candida bloodstream infections. | candida species are the fourth most common cause of bloodstream infection (bsi) in the hospitalized patient. candida glabrata is the most common non-candida albicans candida species in england and wales with an attributed mortality of 48%. c. glabrata is known to demonstrate reduced susceptibility to fluconazole, resulting in treatment failures when employing this agent for empirical treatment of candida bsi. the first part of this study demonstrated a technique utilizing a blood culture system ... | 2007 | 18033833 |
| [aortoduodenal fistula revealed by acute fever with heavy and swollen red leg]. | aortoduodenal fistulas are rare and severe complications of aortic prostheses. the clinical picture usually includes digestive features and fever, unlike our observation where fistula was revealed by heavy and swollen leg with cutaneous septic abscesses but no digestive signs. | 2007 | 18033065 |
| characterization of a parainfluenza virus isolated from a bottlenose dolphin (tursiops truncatus). | a novel member of the parainfluenza virus family was identified in a bottlenose dolphin with respiratory disease. the case animal was a 19-year old male atlantic bottlenose dolphin (tursiops truncatus) that presented with signs of respiratory illness, including raspy, foul-odored breaths and cream-colored exudate from the blowhole. focally extensive pyogranulomatous bronchointerstitial pneumonia with moderate numbers of intralesional yeast organisms was identified on histopathological examinatio ... | 2008 | 18031960 |
| biological consequences of statins in candida species and possible implications for human health. | the statins, simvastatin and atorvastatin are the most widely prescribed drugs. statins lower cholesterol levels through their action on hmg-coa (3-hydroxy-3-methylglutaryl-coa) reductase, an essential enzyme for the biosynthesis of cholesterol. fungal hmg-coa reductases are also inhibited by statins, resulting in reduced levels of ergosterol (the fungal equivalent of cholesterol) and concomitant growth inhibition. this effect occurs in a range of fungal species and possibly affects fungal colon ... | 2007 | 18031260 |
| therapy and outcome of candida glabrata versus candida albicans bloodstream infection. | candida glabrata is a common cause of bloodstream infection (bsi) and exhibits reduced susceptibility to antifungal agents. those with c. glabrata bsi may therefore be at increased risk for a delay in receiving appropriate therapy and poor treatment outcome. we compared treatment and outcome of patients with c. glabrata to controls with candida albicans bsi. each patient with c. glabrata bsi from july 1997 through december 2004 was matched with a control patient infected with c. albicans. approp ... | 2008 | 18024053 |
| epidemiological investigation and typing of candida glabrata clinical isolates by ftir spectroscopy. | candida glabrata has emerged as one of the leading agents of fungal infections and strain typing is essential for epidemiological investigation that is generally achieved by molecular techniques. in this work, we studied twenty-nine c. glabrata strains isolated from different patients, using a phenotypic approach based on fourier transform infrared (ftir) spectroscopy, which has been in a previous study successfully applied as a rapid typing method for candida albicans. a two-step procedure was ... | 2007 | 18022718 |
| yarrowia lipolytica vesicle-mediated protein transport pathways. | protein secretion is a universal cellular process involving vesicles which bud and fuse between organelles to bring proteins to their final destination. vesicle budding is mediated by protein coats; vesicle targeting and fusion depend on rab gtpase, tethering factors and snare complexes. the génolevures ii sequencing project made available entire genome sequences of four hemiascomycetous yeasts, yarrowia lipolytica, debaryomyces hansenii, kluyveromyces lactis and candida glabrata. y. lipolytica ... | 2007 | 17997821 |
| multicenter evaluation of the candida albicans/candida glabrata peptide nucleic acid fluorescent in situ hybridization method for simultaneous dual-color identification of c. albicans and c. glabrata directly from blood culture bottles. | we evaluated the performance of the candida albicans/candida glabrata peptide nucleic acid fluorescent in situ hybridization (pna fish) method, a rapid two-color assay for detection of c. albicans and c. glabrata, in a multicenter study. the assay is designed for use directly from positive blood culture bottles in a fish format. intact, fixed cells are labeled fluorescent green (c. albicans) or fluorescent red (c. glabrata) by rrna hybridization of fluorophore-labeled pna probes. results are ava ... | 2008 | 17977998 |
| a rare case of acute renal failure due to massive renal allograft infiltration with candida glabrata. | 2008 | 17977879 | |
| [species composition of yeast-like fungi isolated from hiv-infected patients]. | the strains of yeast-like fungi isolated from hiv-infected people in 1994-2005 were examined. it was found that a share of non-albicans strains increased up to 46.2%, in monoculture they were present in 40% of examined patients, candida glabrata (21.3%) being the dominant species. the definition of proteolytic activity as one of the factors of pathogenicity showed that it was typical of 90% of museum strains and 58% of fresh isolates. | 2007 | 17977446 |
| synthesis and spectral studies of organotin(iv) 4-amino-3-alkyl-1,2,4-triazole-5-thionates: in vitro antimicrobial activity. | some di- and triorganotin(iv) triazolates of general formula, r(4-n)snln (where n=2; r=me, n-bu and ph; n=1; r=me, n-pr, n-bu and ph and hl=4-amino-3-methyl-1,2,4-triazole-5-thiol (hl-1); and 4-amino-3-ethyl-1,2,4-triazole-5-thiol (hl-2)) were synthesized by the reaction of r(4-n)sncln with sodium salt of hl-1 and hl-2. the bonding and coordination behavior in these derivatives have been discussed on the basis of ir and 119sn mössbauer spectroscopic studies in the solid state. their coordination ... | 2008 | 17977061 |
| lactobacillus fermentum ess-1 with unique growth inhibition of vulvo-vaginal candidiasis pathogens. | the aim of this study was to characterize human isolates of lactobacillus species for their capacity to interfere with the growth of different strains of candida species in vitro in the search for a potential probiotic. growth inhibition of candida species was screened using an agar-overlay method. inhibiting strains were selected to assay the effect of a cell-free lactobacillus culture filtrate (lcf) on the growth of isolates of candida albicans and candida glabrata. a total of 126 human lactob ... | 2007 | 17965352 |
| ascending pneumonia complicating endoscopic therapy of a pancreatic abscess. | 2007 | 17957611 | |
| intramural tracking in esophageal pseudodiverticulosis. | 2007 | 17957608 | |
| oral candida colonization of human immunodeficiency virus infected subjects in turkey and its relation with viral load and cd4+ t-lymphocyte count. | the association of asymptomatic oral candida colonization with the markers of immunodeficiency and hiv is not clear yet. in addition, the prevalence of different candida species colonizing the oral cavity of hiv-infected patients in turkey remains unknown. to evaluate these subjects, oral rinse samples were taken from 64 hiv-positive individuals who have come to the department of microbiology and clinical microbiology, istanbul medical faculty for viral load and cd4(+) t-lymphocyte count measure ... | 2007 | 17944711 |
| [is there a change in ecology of candida species incriminated in fungemia? a 7 years study at foch hospital]. | some candidemia studies have documented changes in epidemiology of candida species and some species were reported as emerging species. we conducted a study over a 6 years period and until 2005 we do not noticed any change in epidemiology of candida even if candida albicans still the most common species followed by candida glabrata. no increase of candidemia was observed from 2000 to 2005 and we observed a decrease during the year 2006, this fact have to be confirm and may be related to other dat ... | 2007 | 17919846 |
| the candida glabrata putative sterol transporter gene cgaus1 protects cells against azoles in the presence of serum. | the uptake of endogenous sterol from serum may allow candida glabrata to survive azole treatment. this study aims to determine the contribution of a sterol transporter that alters fluconazole sensitivity in the presence of serum. | 2007 | 17913716 |
| antimicrobial activity of extracts of the lichen parmelia sulcata and its salazinic acid constituent. | the antimicrobial activity of the acetone, chloroform, diethyl ether, methanol, and petroleum ether extracts of the lichen parmelia sulcata and its salazinic acid constituent have been screened against twenty eight food-borne bacteria and fungi. all of the extracts with the exception of the petroleum ether extract showed antimicrobial activity against aeromonas hydrophila, bacillus cereus, bacillus subtilis, listeria monocytogenes, proteus vulgaris, yersinia enterocolitica, staphylococcus aureus ... | 2007 | 17913083 |
| accumulation of cds nanoparticles by yeasts in a fed-batch bioprocess. | the yeasts schizosaccharomyces pombe and candida glabrata were successfully cultivated in a fed-batch process at cadmium levels up to 100 mg l(-1). s. pombe incorporated 20 mg c dg(-1) dry biomass within 24h. c. glabrata accumulated 8 mg c dg(-1) dry biomass in 24h. the higher cd uptake from s. pombe cells correlate with the elevated glucose concentrations during and at the end of the cultivation. analysis of the cells with energy-filtering transmission electron microscopy-element specific imagi ... | 2007 | 17900736 |
| new ethacridine derivatives as the potential antifungal and antibacterial preparations. | until the 20th century fungal infections were rather easy cured, and the need of new antifungal drugs was low. however, low choice of antifungal preparations, their toxicity, limited spectrum of action, and ability to produce resistant strains show the need of new effective medicines for systemic fungal diseases in nowadays. our goal of research was to synthesize new antimicrobial compounds containing three or more pharmacophores in one molecule. the initial 5-substituted-2-methylmercaptothiazol ... | 2007 | 17895642 |
| synthesis, antifungal and antimycobacterial activities of new bis-imidazole derivatives, and prediction of their binding to p450(14dm) by molecular docking and mm/pbsa method. | new bis-imidazole derivatives have been synthesized and their antifungal and antimycobacterial activity was determined. almost all compounds exhibited a moderate to good activity against two clinical isolates of candida albicans 3038 and candida glabrata 123. the same compounds showed an interesting killing activity against mycobacterium tuberculosis h(37)rv reference strain. docking procedures combined with molecular dynamics simulations in the mm/pbsa framework of theory were applied to predic ... | 2007 | 17888669 |
| pneumonia caused by candida krusei and candida glabrata in a patient with chronic myeloid leukemia receiving imatinib mesylate treatment. | in this report we describe a patient suffering from chronic myeloid leukemia (cml), who was treated for 4.5 years with imatinib and developed pneumonia caused by two candida species, i.e., c. krusei and c. glabrata. the patient was in complete hematologic remission and molecular analyses did not display the presence of tlr2-r752q, tlr4-d299g and tlr4-t399i polymorphisms that may predispose individuals to fungal infections. this case report indicates that in some patients, as previously observed, ... | 2008 | 17885950 |
| correlation of posaconazole minimum fungicidal concentration and time kill test against nine candida species. | we evaluated the in vitro activity of posaconazole against nine candida species using minimum fungicidal concentration (mfc) measurements and time-kill methods. | 2007 | 17875607 |
| [in vitro antifungal activity of voriconazole: new data after the first years of clinical experience]. | voriconazole has been developed to meet the increasing need for new and useful antifungal agents for the treatment of invasive mycoses. this review describes the spectrum of voriconazole antifungal activity based on data from in vitro studies published during the last three years. this survey demonstrates that voriconazole has a broad antifungal spectrum against the most common fungal pathogens being its action fungistatic for candida and fungicidal for aspergillus and other filamentous fungi. o ... | 2007 | 17874856 |
| susceptibility patterns of candida species recovered from canadian intensive care units. | the objective of this study was to determine the speciation and susceptibility patterns of candida species recovered from canadian intensive care units (icus) during a 1-day point-prevalence study on fungal colonization/infection in canadian icus. | 2007 | 17869976 |
| multiple-locus variable-number tandem-repeat analysis for rapid typing of candida glabrata. | a multiple-locus variable-number tandem-repeat analysis (mlva) using six microsatellite markers was assessed in 127 candida glabrata isolates. thirty-seven different genotypes, stable both in vitro and in vivo, were observed. the highest discriminatory power (d = 0.902) was reached by using only four markers. mlva seems to be relevant for c. glabrata typing. | 2007 | 17855568 |
| candida glabrata and candida albicans; dissimilar tissue tropism and infectivity in a gnotobiotic model of mucosal candidiasis. | germ-free transgenic epsilon 26 (tgepsilon26) mice, deficient in both natural killer (nk)- and t-cells, were inoculated (orally) with each of two candida glabrata (bg2 or bg1003) or candida albicans (caf2-1 or sc5314) strains. candida glabrata- or c. albicans-colonized mice exhibited similar numbers of viable candida in the alimentary tract. neither c. glabrata nor c. albicans caused systemic candidiasis of endogenous (alimentary tract) origin. candida albicans invaded oroesophageal (tongue, pal ... | 2007 | 17854475 |
| the pan-ac assay: a single-reaction real-time pcr test for quantitative detection of a broad range of aspergillus and candida species. | in view of the growing incidence and the high mortality of invasive aspergillosis and candidiasis, adequate diagnostic techniques permitting timely onset of treatment are of paramount importance. more than 90 % of all invasive fungal infections in immunocompromised individuals can be attributed to candida and aspergillus species. to date, standardized techniques permitting rapid, sensitive and, no less importantly, economic screening for the clinically most relevant fungi are lacking. in the pre ... | 2007 | 17761478 |
| changing pattern of candidaemia 2001-2006 and use of antifungal therapy at the university hospital of vienna, austria. | a retrospective survey of candidaemia between 2001 and 2006 was performed at the university hospital of vienna, a 2200-bed centre with large organ transplantation and haematology-oncology units. the incidence rate of candida spp. in blood cultures increased from 0.27 cases/1000 admissions in 2001 to 0.77 cases/1000 admissions in 2006 (p <0.005). the incidence of candidaemia caused by candida albicans and by non-albicans candida spp. both increased during this period; although there was a trend t ... | 2007 | 17725647 |
| assimilation of nad(+) precursors in candida glabrata. | the yeast pathogen candida glabrata is a nicotinamide adenine dinucleotide (nad(+)) auxotroph and its growth depends on the environmental supply of vitamin precursors of nad(+). c. glabrata salvage pathways defined in this article allow nad(+) to be synthesized from three compounds - nicotinic acid (na), nicotinamide (nam) and nicotinamide riboside (nr). na is salvaged through a functional preiss-handler pathway. nam is first converted to na by nicotinamidase and then salvaged by the preiss-hand ... | 2007 | 17725566 |
| quiz page. acute renal failure caused by renal allograft infection with c glabrata. | 2007 | 17724848 | |
| candida interface keratitis after deep anterior lamellar keratoplasty: clinical, microbiologic, histopathologic, and confocal microscopic reports. | to report the clinical, histopathologic, microbiologic, and confocal microscopic features of candida keratitis after deep anterior lamellar keratoplasty (dalk). | 2007 | 17721287 |
| dna microarray-based detection and identification of fungal pathogens in clinical samples from neutropenic patients. | the increasing incidence of invasive fungal infections (ifi) in immunocompromised patients emphasizes the need to improve diagnostic tools. we established a dna microarray to detect and identify dna from 14 fungal pathogens (aspergillus fumigatus, aspergillus flavus, aspergillus terreus, candida albicans, candida dubliniensis, candida glabrata, candida lusitaniae, candida tropicalis, fusarium oxysporum, fusarium solani, mucor racemosus, rhizopus microsporus, scedosporium prolificans, and trichos ... | 2007 | 17715373 |
| erythematous candidosis in patients with complete dentures and hiv+/aids. | this investigation was designed to evaluate the frequency of erythematous candidosis (ec) and candida species, proteinase and phospholipase exoenzyme production, and to compare clinical features in patients with complete dentures and hiv+/acquired immunodeficiency disease syndrome (aids). fifty-one patients were selected from a total of 285 with ec: denture wearers (n = 30) and hiv+/aids (n = 21). the yeast prevalence and the production of exoenzymes, such as proteinase and phospholipase by cand ... | 2007 | 17714362 |
| community-onset candidemia at a university hospital, 1995-2005. | although not all candidemias are hospital-acquired, data on clinical epidemiology for the community-onset candidemia are limited. this retrospective study was conducted to describe predisposing factors and outcomes of community-onset candidemias. | 2007 | 17712471 |
| production of indole pigments by candida glabrata. | when provided as the sole nitrogen source tryptophan induces the production of several indole alkaloids, e.g., pityriacitrin, malasseziaindole, pityriaanhydride and pityriarubin with proven biological activity in the lipophilic yeast malassezia furfur. so far these pigments seem to have been unique and only produced by highly specialized basidiomycetal yeasts of the genus malassezia. having surprisingly observed a brown pigmented candida glabrata isolate as a contaminant on such a pigment induci ... | 2007 | 17710621 |
| [in vitro activity of amphotericin b, fluconazole and itraconazole against candida glabrata strains isolated from clinical samples]. | in recent years, the incidence of candida albicans infections tends to decrease, at least in some centers other candida species have emerged as opportunistic pathogens. among non-albicans candida species, c. glabrata is one of the most frequently isolated species. in this study, the in vitro activities of amphotericin b, itraconazole and fluconazole were tested against 134 clinical c. glabrata strains. the isolation and identification of the isolates were done by standard mycological methods. mi ... | 2007 | 17682710 |
| attachment and entry of candida famata in monocytes and epithelial cells. | candida albicans is considered the main pathogenic yeast responsible for a multitude of infective disorders. however, other yeasts, such as candida famata, are being recognized as potential emerging pathogens that cause several types of infections in humans and animals. consequently, we have investigated the adhesion and internalization of candida famata into monocytes and epithelial cells. the interaction of the yeast with the cells is very rapid and takes place during the first 15 min of injec ... | 2007 | 17661391 |
| [minimal inhibitory concentrations of candida species to five antifungals by using the reference dilution micromethod and the e-test.]. | it is accepted that the frequency of candidosis has increased during the last decade, specially in hospitalized patients. the more frequent use of azole antifungals and the recognition of isolates of candida sp resistant to these and other drugs such as 5-fluorocytosine constitute a great need for a reproducible and useful c. albicans in vitro susceptibility testing method for monitoring antifungal therapy in clinical mycological laboratories. the e-test is a novel agar diffussion technique for ... | 1997 | 17655386 |
| in vitro antimicrobial properties of coconut oil on candida species in ibadan, nigeria. | the emergence of antimicrobial resistance, coupled with the availability of fewer antifungal agents with fungicidal actions, prompted this present study to characterize candida species in our environment and determine the effectiveness of virgin coconut oil as an antifungal agent on these species. in 2004, 52 recent isolates of candida species were obtained from clinical specimens sent to the medical microbiology laboratory, university college hospital, ibadan, nigeria. their susceptibilities to ... | 2007 | 17651080 |
| one year prospective survey of candida bloodstream infections in scotland. | a 12 month survey of candidaemia in scotland, uk, in which every scottish hospital laboratory submitted all blood isolates of yeasts for identification, strain typing and susceptibility testing, provided 300 isolates from 242 patients, generating incidence data of 4.8 cases per 100,000 population per year and 5.9 cases per 100,000 acute occupied bed days; 27.9 % of cases occurred in intensive care units. more than half the patients with candidaemia had an underlying disease involving the abdomen ... | 2007 | 17644714 |
| comprehensive review of conventional and non-conventional methods of management of recurrent vulvovaginal candidiasis. | recurrent vulvovaginal candidiasis (vvc) is a condition what causes women a great deal of discomfort, inconvenience, and sometimes has psychological sequelae.(1) this condition is notoriously difficult to manage. conventional management is generally favoured by medical practitioners. some practitioners prefer not to offer other options because of significant possible side-effects and the lack of research supporting alternative treatments. there are many studies and much available information sur ... | 2007 | 17627679 |
| the high-osmolarity glycerol response pathway in the human fungal pathogen candida glabrata strain atcc 2001 lacks a signaling branch that operates in baker's yeast. | the high-osmolarity glycerol (hog) mitogen-activated protein (map) kinase pathway mediates adaptation to high-osmolarity stress in the yeast saccharomyces cerevisiae. here we investigate the function of hog in the human opportunistic fungal pathogen candida glabrata. c. glabrata sho1delta (cgsho1delta) deletion strains from the sequenced atcc 2001 strain display severe growth defects under hyperosmotic conditions, a phenotype not observed for yeast sho1delta mutants. however, deletion of cgsho1 ... | 2007 | 17616630 |
| [candida glabrata chorioamnionitis following in vitro fertilization]. | we report one case of severe candida glabrata chorioamnionitis and septicemy occurring in a twin pregnancies achieved by in vitro fertilization techniques which resulted in pregnancy loss after preterm rupture of the membrane at 22 weeks of gestation despite a treatment with amphotericin b. | 2007 | 17616266 |
| rhodotorula glutinis fungemia in a liver-kidney transplant patient. | a 54-year-old man underwent simultaneous liver-kidney transplantation. during his prolonged hospitalization, he developed catheter-related fungemia with rhodotorula glutinis and azole-resistant candida glabrata. management of the rhodotorula fungemia was complicated by his renal insufficiency, hepatic insufficiency, and the concurrent fungemia with multi-azole resistant c. glabrata. he was treated with combination therapy with voriconazole and micafungin with subsequent clearance of the fungemia ... | 2008 | 17605726 |
| comparison of a randomly amplified polymorphic dna (rapd) analysis and atb id 32c system for identification of clinical isolates of different candida species. | the objective of this work was to compare the usefulness of a randomly amplified polymorphic dna (rapd) assay to that of the atb id32c kit (biomérieux, france) for identification of different species of candida isolated from clinical specimens. the rapd-pcr patterns obtained with ope-18 primer for identification of clinical isolates were consistent, and the different independent assays revealed reproduction of the band patterns. rapd with the ope-18 primer is a very specific and sensitive method ... | 2007 | 17604435 |
| breakthrough fungal infections after allogeneic hematopoietic stem cell transplantation in patients on prophylactic voriconazole. | seventy-one allograft recipients receiving voriconazole, in whom complete clinical, microbiologic and pharmacokinetic data were available, were studied to determine the efficacy of voriconazole in preventing fungal infections. the length of voriconazole therapy was 6-956 days (median 133). the total number of patient-days on voriconazole was 13 805 ( approximately 38 years). a total of 10 fungal infections were seen in patients on voriconazole (18% actuarial probability at 1 year): candida glabr ... | 2007 | 17589527 |
| the medically important yeasts present in clinical specimens. | in an effort to determine the yeast species present in clinical specimens obtained from patients attending a busy saudi hospital, the present study was undertaken. more than 1614 yeasts were isolated in culture from pathologic specimens of over 1303 patients with diverse clinical conditions. organisms identified in 22 species of eight general included: candida albicans, c. parapsilosis, c. tropicalis, c. krusei, c. lipolytica, c. guilliermondii, c. pseudotropicalis, c. pinotolopesii, c. humicola ... | 1992 | 17589130 |
| a phylogenetic analysis of the sugar porters in hemiascomycetous yeasts. | a total of 214 members of the sugar porter (sp) family (tc 2.a.1.1) from eight hemiascomycetous yeasts: saccharomyces cerevisiae, candida glabrata, kluyveromyces lactis, ashbya (eremothecium) gossypii, debaryomyces hansenii, yarrowia lipolytica, candida albicans and pichia stipitis, were identified. the yeast sps were classified in 13 different phylogenetic clusters. specific sugar substrates could be allocated to nine phylogenetic clusters, including two novel tc clusters that are specific to f ... | 2007 | 17587872 |
| changes in karyotype and azole susceptibility of sequential bloodstream isolates from patients with candida glabrata candidemia. | we examined the changes in genotypes and azole susceptibilities among sequential bloodstream isolates of candida glabrata during the course of fungemia and the relationship of these changes to antifungal therapy. forty-one isolates were obtained from 15 patients (9 patients who received antifungal therapy and 6 patients who did not) over periods of up to 36 days. the isolates were analyzed using pulsed-field gel electrophoresis (pfge) and multilocus sequence typing (mlst) and tested for antifung ... | 2007 | 17581937 |