Publications

the response of the lung to foreign compounds that produce free radicals.		1986	2423026
[occlusive and nonocclusive mesenteric ischemia. anamnestic and clinical findings].		2008	2422844
[surgery of intestinal hemorrhage].		2008	2422843
m cell transport of vibrio cholerae from the intestinal lumen into peyer's patches: a mechanism for antigen sampling and for microbial transepithelial migration.	viable vibrio cholerae o1 were inoculated into the intestinal lumen of nonimmune rabbits. the vibrios were phagocytosed by m cells over peyer's patch lymphoid follicles, carried in vesicles through the epithelium, and discharged among underlying lymphocytes and macrophages. autoradiography of v. cholerae labeled with [2-3h]adenine confirmed transport. indigenous bacteria with and without capsules were also taken up from control loops and carried through m cells into peyer's patches. v. cholerae ...	1986	2422297
augmentation of natural killer activity by neuraminidase treatment of lymphocytes from tumor-bearing mice.	spleen cells from tumor-bearing mice showed decreased natural killer (nk) activity and decreased binding to target cells with progression of the tumor. treatment of spleen cells from tumor-bearing mice with vibrio cholerae neuraminidase (vcn) increased the cytotoxicity to a level twice or more as high as that of untreated cells, but the same treatment of spleen cells from normal mice had no or little effect. on the other hand, neither in spleen cells from tumor-bearing mice nor in those from nor ...	1986	2421536
effect of carrier on the immunogenic capacity of synthetic cholera vaccine.	in the design of the synthetic antigens and synthetic vaccines, primary consideration should be given to the choice of the carrier. since small peptides which are being used as the relevant antigenic determinants are likely to be poor immunogens as such, the augmentation of their immunogenic capacity by the carrier or any other means is crucial for the induction of immunity. in the present study, we explored several approaches for the enhancement of the immune response towards synthetic peptides ...	1985	2421153
electrophoretic resolution of microheterogeneity in vibrio cholerae lipopolysaccharide.	lipopolysaccharide (lps) from vibrio cholerae has been analysed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. under normal conditions of electrophoresis which resolve escherichia coli lps, v. cholerae lps shows two diffuse and unresolved bands. however, on long gels at low concentration it can be resolved into two major band types. there are at least 10 slow moving, discrete bands of regular periodicity and three fast moving bands. comparison with lps from e. coli indicates that ...	1985	2417638
isolation and characterization of influenza c virus inhibitor in rat serum.	two hemagglutination inhibitors for influenza c virus were isolated from pooled sera of normal rats by sequential chromatography on blue sepharose cl 6b, ultrogel aca 22, and deae-cellulose. the two inhibitors were identified as alpha 1-macroglobulin and murinoglobulin by comparison with the authentic samples. these inhibitors abolished the hemagglutination by influenza c virus strains but did not affect the hemagglutination by influenza a and b virus strains. hemagglutination inhibition activit ...	1985	2416143
differences in carbohydrate specificities and complement-activating capacity of guinea pig and human antibodies to neuraminidase-treated autologous erythrocytes.	guinea pig erythrocytes desialated by treatment with neuraminidase from vibrio cholerae were lyzed in autologous serum through a natural-antibody-dependent activation of the classical complement pathway. lysis was inhibited when a mannose, glucose, galactose or n-acetyl-glucosamine was added to the incubation mixture. methyl-alpha- or -beta-d-galactopyranosides were poorly effective and n-acetyl-d-galactosamine was not effective at all. inhibition of lysis by the carbohydrates was due neither to ...	1985	2415814
post operative stimulation of cell mediated immunity.	the consequences of altered immuno-competence resulting from anaesthesia and surgery are potentially hazardous to the patient with malignant disease. malnutrition also produces reduction in cell mediated immunity, a condition which is commonly incurred in patients with neoplastic disorders. numerous agents have been claimed to stimulate the immune responses but few have proved to be of practical value. this paper reports the use variously of protease inhibitors, using aprotinin, and post operati ...	2008	2415748
[vital staining of the conjunctiva for prevention of epithelial implantation cysts].	selective vital staining with 1% toluidine blue makes short-term intraoperative differentiation of the conjunctiva from tenon's capsule possible. it is used with advantage in operations where the anatomical situation is unclear to avoid displacement of conjunctival epithelium into deeper tissues and subsequent growth of cysts. examples of its application are reoperations with excessive scars after squint or detachment surgery, wound dehiscence after enucleations, lacerated wounds after accidents ...	1985	2415747
[pedicled papilloma of the conjunctiva with papilloma virus. immunohistochemical detection of species specific papilloma-virus antigens].	report on the immunohistochemical detection of genus-specific papillomavirus antigen with an immunoperoxidase technique - in a papilloma of the caruncle, in which papillomavirus-specific dna was previously successfully, demonstrated in a virological examination by means of hybridization of nucleic acid.	2008	2415746
transcriptional and post-transcriptional regulation of l-type pyruvate kinase in diabetic rat liver by insulin and dietary fructose.	regulation of the expression of the hepatic l-type pyruvate kinase gene by insulin and dietary fructose was studied in diabetic rats. insulin increased the levels of putative nuclear rna precursor species of this enzyme in parallel with that of total cellular pyruvate kinase l mrna. these changes occurred more slowly than those induced by dietary fructose. insulin caused a 3-fold increase in transcription of the pyruvate kinase l gene after 6 h and a 6-fold increase after 16 h. the increase caus ...	1985	2414297
syngeneic monoclonal antibody against melanoma antigen with interspecies cross-reactivity recognizes gm3, a prominent ganglioside of b16 melanoma.	it has previously been reported that a mouse (c57bl/6) monoclonal antibody, m2590, was established against syngeneic melanoma b16 cells, which was shown to react only with melanoma cells from various species but not with other tumor cells or normal tissues (taniguchi, m., and wakabayashi, s. (1984) gann 75, 418-426). in the present study, the specificity of m2590 antibody was shown to be directed to a saccharide arrangement (neuac alpha 2-3gal beta 1-4glc (or -glcnac)) of gangliosides by three d ...	1985	2414279
protective characteristics of the antigen common to pseudomonas and vibrio and significance of bacterial endotoxins in protection against selected bacterial infections.	the protective effect of different vaccines against the killing activity of pseudomonas aeruginosa and vibrio parahaemolyticus for mice was studied. cross experiments confirmed the high protective effect of the pseudomonas common antigen (original endotoxin protein) contained in pseudomonas vaccine, which, together with other soluble components, substantial afforded protection of mice against vibrios and thus confirmed the antigenic relationship between pseudomonas and vibrio. satisfactory resul ...	1985	2413656
characterization of an unique rna initiated immediately upstream from human alpha 1 globin gene in vivo and in vitro: polymerase ii-dependence, tissue specificity, and subcellular location.	we have identified an abundant transcript initiated upstream from the canonical cap site of human alpha 1 globin gene in bone marrow cells and in cos-7 cells transfected with an alpha 1 globin gene-containing plasmid. similar to the major alpha 1 globin transcript, this upstream rna is present almost exclusively in the cytoplasm of the transfected cos-7 cells. it is also synthesized efficiently in vitro by rna polymerase ii in the nuclear extracts prepared from a hela cell line and an erythroleu ...	1985	2413422
genetics of insulin-specific helper and suppressor t cells in nonresponder mice.	the role of insulin-specific helper and suppressor t cells in the h-2-linked genetic control of antibody responses to heterologous insulins was examined in vitro. these data demonstrate that pork insulin stimulates both primed helper t cells and dominant suppressor t cells in all nonresponder strains tested. thus, the nonresponder phenotype is attributed to the activation of specific suppressor t cells rather than to an absence of helper t cell activity. examination of the antigenic cross-reacti ...	1985	2413109
expression of epidermal keratins and filaggrin during human fetal skin development.	the major structural proteins of epithelia, the keratins, and the keratin filament-associated protein, filaggrin, were analyzed in more than 50 samples of human embryonic and fetal skin by one-dimensional sds page and immunoblotting with monoclonal and polyclonal antibodies. companion samples were examined by immunohistochemistry and electron microscopy. based on structural characteristics of the epidermis, four periods of human epidermal development were identified. the first is the embryonic p ...	1985	2413039
a simple method for counting nuclei in the preimplantation mouse embryo.	an easy and rapid method of counting the number of cells in the preimplantation mouse embryo is described. the procedure increases the speed with which large numbers of embryos can be processed using a simple squash technique. cell numbers are determined by exposing the embryos to the fluorescent dna-binding dye, hoechst 33258, removing the zona pellucida and simply squashing the embryo and counting the number of fluorescent nuclei. an increase in fluorescent intensity and maintenance of nuclear ...	1985	2412884
a study on the pharmacokinetics in mouse of adenine-9-beta-d-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin.	in plasma of mice injected with adenine-9-beta-d-arabinofuranoside monophosphate (ara-amp) coupled to human lactosaminated serum albumin (l-hsa) some of the ara-amp molecules are enzymatically released, whereas others remain linked to l-hsa. evidence has been obtained that ara-amp is not deaminated when it is conjugated to l-hsa, in contrast to the free drug which is rapidly metabolized to its hypoxanthine derivative.	1985	2412878
[basic factors of the pathogenicity of vibrio cholerae].		1985	2412368
membrane-bound 5'-nucleotidase in marine luminous bacteria: biochemical and immunological properties.	a novel 5'-nucleotidase previously described in halophilic vibrio costicola was detected in marine vibrio and photobacterium strains. the enzyme of marine bacteria was similar in its properties to the 5'-nucleotidase of vibrio costicola; it was outwardly oriented in the cytoplasmic membrane and dephosphorylated nucleoside 5'-tri-, di-, and mono-phosphates to respective nucleosides before uptake. the enzyme in marine strains was immunologically cross-reactive with the antibody raised against the ...	1985	2411368
immunological characterization of vibrio cholerae o:1 lipopolysaccharide, o-side chain, and core with monoclonal antibodies.	lipopolysaccharide (lps) was extracted from vibrio cholerae o:1 strains of the serotypes ogawa, inaba, and hikojima and delipidated by mild-acid hydrolysis. two polysaccharide fragments with the molecular weights of approximately 9,000 and 900, respectively, were isolated by gel permeation chromatography. the lps preparations and the polysaccharide fragments were studied in enzyme-linked immunosorbent assay inhibition, rocket immunoelectrophoresis, and sodium dodecyl sulfate-polyacrylamide gel e ...	1985	2410362
rapid detection of vibrio cholerae o:1 by motility inhibition and immunofluorescence with monoclonal antibodies.	monoclonal antibodies against the group and type specific antigens of vibrio cholerae o:1 lipopolysaccharide were used for the rapid detection of vibrio cholerae strains by motility inhibition and immunofluorescence. motility inhibition of live vibrio cholerae o:1 was obtained with group specific monoclonal antibodies. monoclonal antibodies against the type specific antigens b (ogawa) and c (inaba) inhibited motility of strains of homologous serotypes only. indirect immunofluorescence of heatfix ...	1985	2410265
catalase enhances damage to dna by bleomycin-iron(ii): the role of hydroxyl radicals.	bleomycin degrades dna under aerobic conditions when a ferrous salt is added. this reaction is enhanced by catalase and certain hydroxyl radical scavengers but inhibited by the addition of hydrogen peroxide. a ferricbleomycin complex is, however, stimulated by addition of hydrogen peroxide. these findings suggest that catalase removes hydrogen peroxide and in so doing prevents loss of ferrous ions and formation of hydroxyl radicals (oh.) by a fenton-type reaction. it further suggests that oh. ra ...	1985	2409975
use of non-carbonated soft drinks to provide safe drinking water.	non-carbonated, low-calorie soft drink concentrates (cordials), when diluted according to manufacturers' instructions, had significant antibacterial effects in vitro. bacteria affected include vibrio cholerae, aeromonas hydrophila, shigella sonnei, salmonella typhimurium and escherichia coli. with vibrios, bacterial counts were reduced from 10(6)/ml to undetectable numbers in less than 10 min. escherichia coli in an initial concentration of 10(6)/ml became undetectable after incubation for 1 h w ...	1985	2409896
fluorescent staining of sialidases in polyacrylamide gel electrophoresis and ultrathin-layer isoelectric focusing.	polyacrylamide gels were stained with the sialidase substrate 2'-(4-methylumbelliferyl)-alpha-d-n-acetylneuraminic acid showing the activity of vibrio cholerae and clostridium sordellii sialidases in the gels after electrophoresis. with this fluorogenic method minimum sialidase activities of 5 microu could be determined. the sensitivity of this staining is about 10,000-fold higher compared to protein-staining with coomassie brilliant blue. for the visualization of other proteins than sialidases ...	1985	2409836
vascular myogenic or stretch-dependent tone.	myogenic tone is an important source of vascular resistance, which appears to depend upon stretch of the vessel wall. it contributes to autoregulation, is dependent upon external calcium, and may involve a calcium-entry mechanism different from that associated with the action of agonists and changes in the membrane potential.	2008	2409386
in vitro antimicrobial activity of bismuth subsalicylate and other bismuth salts.	this report demonstrates that bismuth subsalicylate (bss) effectively inhibits growth of a number of bacterial strains known to cause diarrhea, including escherichia coli, salmonella, shigella, and campylobacter. other bismuth salts and sodium salicylate, a hydrolysis product of bss in the gut, also were examined and were shown to have various degrees of activity. growth of the organisms was monitored in vitro by inoculating culture fluid that contained one of the compounds to be tested and dete ...	1990	2406851
aetiological studies of diarrhoeal diseases in infants and young children in iran.	the aetiology of diarrhoeal diseases was investigated among 715 patients admitted to four children's hospitals in tehran, during february 1986 to march 1987, and also among 443 patients attending the central out-patient clinic in sanandaj, state of kordestan, during october 1986. enteropathogenic escherichia coli (epec) were the most common pathogens found in both areas. almost 26.7% of the patients in tehran and 20.1% of the patients in sanandaj were infected with epec. enterotoxigenic e. coli ...	1990	2406458
effects of the d-1 agonist skf-38393 combined with haloperidol in schizophrenic patients.		2008	2405808
health care in the united states. our dynamic jigsaw puzzle.		2008	2405797
non-01 vibrio cholerae septicemia: a case report.		1990	2402675
[re-evaluation of the improved double eyelid surgery using the suture and ligation method].		2008	2397442
[genomic "dactyloscopy" in the expertise of disputed paternity and the determination of biological relationship].	genome "dactyloscopy" (dna fingerprinting) is a principally new way of personal identification based on analysis of human genetic material (dna); the difference in dna structure of different subjects is the scientific basis of this method. this ensures opportunity to estimate biological relationship of persons positively. the authors were the first to demonstrate using certain expert material the adequacy and potentials of dna fingerprinting by m 13 probe for medicolegal expert practice in most ...	1990	2396289
[ethics in dental practice].	after a discussion of the foundations of ethical thinking in general, a link is made to the professional ethics for medical and dental practitioners. professional ethics are constantly influenced by the changing society, although some values remain fundamental. a critical look at existing ethical codes for dentists is followed by some examples of the wider context in which dental care is provided and its ethics influenced. not only safeguarding of professionalism in dental treatment but the fulf ...	1981	2396023
[microbiological evaluation of complex preventive program in adult years--schwerin prevention study].		1980	2395989
[interpretation of radiographs].		1980	2395982
prepuberal mpoa lesions and housing condition: effects on rats' male sex behaviors.	after prepuberal male rats underwent either medial preoptic area (mpoa) lesions or sham surgeries, they were housed in all-male groups (soc-x and soc-s treatments) or isolation (iso-x and iso-s treatments). in the first mating test, soc-x rats mounted and intromitted more than iso-x, but not soc-s, rats. in this and across mating tests, soc-x did not differ from soc-s rats in the proportion ejaculating; however, fewer iso-x than iso-s rats ejaculated. in the first ejaculatory test, mpoa-lesioned ...	1990	2395934
acute, chronic, and interactive effects of type i and ii corticosteroid receptor stimulation on feeding and weight gain.	type i (aldosterone) and/or type ii (dexamethasone or ru28362) corticosterone receptor agonists were continuously infused in adrenalectomized sprague-dawley rats for 28 days at doses of 3.4, 17.2, or 86.2 nmol/day. additional groups received combined agonist infusions, blank infusions, or sham operations. the type i agonist stimulated body weight gain, and the type ii agonists were both suppressive, differing mainly in degree. although there were a few early effects of these hormones (usually a ...	1990	2395928
[testosterone metabolism in discrete areas of the brain in rat fetuses].	experiments in vitro with further thin-layer chromatography of steroids were staged to investigate changing of 3h-testosterone into 3h-estradiol-17 beta and 3h-5 alpha-reduced metabolites in a fraction of 1000 g of homogenates of the medial preoptic area (mpa), the paraventricular nuclei (pvn), the dorsal vagal complex (dvc) of the lower cerebral trunk, the rostral and caudal parts of the amygdaloid complex (acr and acc) of the brain of 21-day male and female rat fetuses. the activity of aromata ...	1990	2395838
[the effect of neurotropic preparations on the sensitivity of the hypothalamo-hypophyseal system to the inhibiting action of dexamethasone].	the effect of 10 neurotropic drugs with the known mechanism of action on the cortisol level was studied in 220 patients with effective psychoses before and after administration of 0.5 mg of dexamethasone. the use of the tranquilizer phenazepam, alpha-adrenoblockers pyrroxane and phentolamine and a new generation antidepressant mianserin blocking alpha-adrenoreceptors, improved considerably the results of a dexamethasone test. pharmacological enhancement of serotoninergic processes with alpha-try ...	1979	2395831
profundus tendon disruption resulting in carpal tunnel syndrome.		1979	2395765
nucleotide sequence of cdna for the cytosolic cu/zn-superoxide dismutase from spinach (spinacia oleracea l.).		1978	2395656
single dose prophylaxis in colorectal surgery.	moxalactam disodium (latamoxef), was evaluated as a single dose prophylactic antibiotic against wound infection in open colorectal surgery. one hundred and five consecutive patients admitted to the university department of surgery, wellington hospital, were studied. twelve patients were excluded because either the antibiotic was not given or antibiotics were given for other reasons. eleven patients developed early wound infections and one further patient developed a late infection, an overall wo ...	1978	2395570
effects of sodium depletion on the caffeine-induced contraction of frog's skeletal muscle.	effects of depletion of na ions from the environmental medium on the caffeine-induced contraction were investigated in both intact and skinned fibers prepared from the frog's fast twitch muscle. in intact muscle fibers, both the twitch and the contracture induced by 5 mm caffeine were enhanced by depleting the external na at 9-10 degrees c. in contrast, in the mechanically skinned muscle fiber, which was used to examine the capability of the sarcoplasmic reticulum to take up ca ions from the sar ...	2008	2395238
metabolism of indium-111-labeled murine monoclonal antibody in tumor and normal tissue of the athymic mouse.	we have studied the fate of radiometal metabolism in vivo by analyzing the molecular form of radiolabeled anti-carcinoembryonic antigen (cea) in tissues. athymic mice bearing colonic tumor xenografts were injected i.v. with 111in-isothiocyanate-benzyl-dtpa-(scn-bz-dtpa) igg or 111in-(scn-bz-dtpa) f(ab')2, and then killed daily for up to four days. liver, kidney, and tumor were extracted and the supernatants, plasma and urine samples were analyzed by hplc, itlc, hpiec and sds-page. by hplc, the a ...	1990	2395019
toxicity of intravesical recombinant human tumor necrosis factor in cynomolgus monkeys.	six groups of two cynomolgus monkeys were treated with escalating intravesicular doses of recombinant human tumor necrosis factor (rhutnf) for a 6 week interval. the doses of rhutnf ranged from 10 ng to 1 mg and were instilled weekly. two monkeys had instillation of saline only and served as controls. the monkeys were weighed and temperatures determined before, immediately after, and 2 days following each treatment. cystoscopic examination was performed 2 days after each treatment and blood samp ...	1990	2395009
are separable aromatase systems involved in hormonal regulation of the male brain?	in vitro study of testosterone (t) metabolism shows that formation of estradiol-17 beta (e2) is regionally specific within the preoptic area (poa) of the male ring dove. the poa is known to be involved in the formation of e2 required for specific components of male sexual behavior. two sub-areas of high aromatase activity, anterior (apoa) and posterior preoptic (ppoa) areas, have been identified. aromatase activity is higher in apoa than in ppoa. the aromatase activity within the apoa is also mo ...	1990	2394989
sex differences in hormonal responses of vasopressin pathways in the rat brain.	vasopressin (avp) immunoreactivity in cells and projections of the bed nucleus of the stria terminalis (bst) and medial amygdaloid nucleus (ma) depends on gonadal steroids. in addition, the avp projections from the bst show denser fiber staining in males than in females. to study whether these differences depend on different hormone levels in adulthood, male and female rats were gonadectomized and similarly treated with testosterone for 4 weeks prior to sacrifice. immunocytochemistry showed that ...	1990	2394985
triiodothyronine augmentation of the antidepressant effect of the nontricyclic antidepressant trazodone.		2008	2394983
phlegm production in plain cigarette smokers who changed to filter cigarettes or quit smoking.	data from a prospective epidemiological study that included 2025 plain cigarette smokers were analysed to investigate the effect of phlegm production of changing to filter cigarettes or quitting smoking. during a 5-year follow-up, 189 subjects quitted smoking, 312 changed to filter cigarettes, while 1524 continued to smoke plain cigarettes. multiple logistic regression was used to adjust for age, duration of smoking, number of cigarettes smoked, socio-economic status and alcohol consumption. smo ...	2008	2394961
spontaneous supratentorial intracerebral haemorrhage: a prognostic study.	a prospective study to determine the prognostic factors of spontaneous supratentorial intracerebral haemorrhage was carried out in 93 cases admitted to the faculty of medicine, siriraj hospital from 1984 to 1986. the overall mortality found in this study was 48.39 per cent, most of which occurred within the first ten days of admission. death resulting from brain herniation secondary to cerebral oedema accounted for 86.05 per cent of those who died. comparison to determine the possible factors re ...	2008	2394957
the physics of spinal manipulation. part iii. some characteristics of adjusting that facilitate joint distraction.	the role of quickness, adjustive amplitude, preadjustive tension, and countertension in facilitating joint distraction to cavitation is investigated. these characteristics are further shown to contribute to joint isolation, protection of joints from injury, and enhanced adjustive efficiency. block and spring "slinky dog" models aid in illustrating the physics principles involved. the complete role of mass and acceleration in the adjustive process is discussed.	1990	2394947
[use of pit and fissure sealants in private practice: the quebec situation].	this paper presents data collected in march of 1989 from a sample of dentists practicing in the province of quebec. a survey was mailed to dentists in order to determine to what degree sealants are used and the various characteristics relative to the dentists in question. other questions related to how dentists obtained information about sealants, the difficulties encountered with their application and the problems relative to their use by the dental profession. the results indicate that nearly ...	2008	2394870
identification of a virb10 protein aggregate in the inner membrane of agrobacterium tumefaciens.	products of the virb operon are proposed components of a membrane-associated t-dna transport apparatus in agrobacterium tumefaciens. here we identified the virb10 gene product and raised specific antiserum to the protein. while the virb10 reading frame contains two potential atg translation start sites located 32 codons apart, we found that only the downstream atg was required for efficient virb10 synthesis. cellular localization studies and analysis of translational fusions with the escherichia ...	1990	2394684
effects of surface tension and viscosity on airway reopening.	we studied airway opening in a benchtop model intended to mimic bronchial walls held in apposition by airway lining fluid. we measured the relationship between the airway opening velocity (u) and the applied airway opening pressure in thin-walled polyethylene tubes of different radii (r) using lining fluids of different surface tensions (gamma) and viscosities (mu). axial wall tension (t) was applied to modify the apparent wall compliance characteristics, and the lining film thickness (h) was va ...	2008	2394665
the role of alternating air and silicore overlays in preventing decubitus ulcers.	patients with chronic neurological diseases who were at high risk of decubitus ulcers were randomly assigned to alternating air on silicore mattress overlays for a period of 3 months. of 148 subjects who completed the trial, more than 50% in each group developed one or more ulcers. no statistically significant differences between groups were found in the incidence, severity, healing duration or the location of the ulcers; with the exception of a significant difference (p less than 0.001) in the ...	2007	2394540
nasolacrimal abnormalities in oblique facial clefts.	a patient with a tessier no. 4 cleft and an associated bifid nasolacrimal system is presented and considered within the tessier classification of craniofacial clefting. previous accounts of nasolacrimal abnormalities associated with facial clefts are reviewed together with the accepted developmental embryology. it is proposed that the bifid nasolacrimal duct system described constitutes a new addition to the literature.	2008	2393773
effectiveness of low-dose lovastatin in lowering serum cholesterol. experience with 56 patients.	this study reviews the progress of 56 consecutive patients with type iia and iib hyperlipoproteinemia following treatment with lovastatin. lovastatin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase, has been shown to have a cholesterol-lowering effect in doses ranging from 10 to 80 mg/d. thus far, however, no large study has been performed to show the effectiveness of low-dose lovastatin (20 mg/d) for more than a 6-week duration. fifty-six patients with known coronary arte ...	1991	2393325
the valsalva manoeuvre.		2007	2391301
role of the p plasmid in attenuation of vibrio cholerae o1.	the conjugative plasmid p of vibrio cholerae has been shown to have a suppressive effect on the virulence of hypertoxigenic strains like 569b. in this study, we have sought to analyze this phenomenon. utilizing the infant mouse cholera model, we have demonstrated that the presence of p increases the 50% lethal dose of v. cholerae classical inaba 569b by more than 300-fold. no effect of p on cholera toxin (ct) production, whether measured by gm1 enzyme-linked immunosorbent assay, by ct activity i ...	1990	2387637
isolation and structure of a novel charged member of the red-pigment-concentrating hormone-adipokinetic hormone family of peptides isolated from the corpora cardiaca of the blowfly phormia terraenovae (diptera).	a hypertrehalosaemic neuropeptide from the corpora cardiaca of the blowfly phormia terraenovae has been isolated by reversed-phase h.p.l.c., and its primary structure was determined by pulsed-liquid phase sequencing employing edman chemistry after enzymically deblocking the n-terminal pyroglutamate residue. the c-terminus was also blocked, as indicated by the lack of digestion when the peptide was incubated with carboxypeptidase a. the octapeptide has the sequence pglu-leu-thr-phe-ser-pro-asp-tr ...	1990	2386478
four years' experience with cyclosporin a in pediatric kidney transplantation.	from 1982 to 1987 sixty-three children were treated with cyclosporin a and low dose prednisolone after kidney transplantation. patient survival rate at 4 years after transplantation was 98.3%, survival rate of living related grafts 100% (n = 10), and survival rate of cadaveric grafts 73% (n = 53). adequate cyclosporin blood levels were achieved in all children with a dosage regimen related to body surface area. major concerns during the observation period were the loss of glomerular filtration r ...	2008	2386053
[groups of the species vibrio cholerae having different epidemic importance].	subdivision of v. cholerae 01 into toxins on the basis of the whole complex of signs characteristic of this species does not make it possible to judge on their epidemic importance and to use the data on identification of v. cholerae for solving practical problems. classification of v. cholerae by their capacity for producing toxin (choleragen and hemolysin of type 1, subtype beta) removes these difficulties.	1990	2385990
attachment of vibrio cholerae serogroup o1 to zooplankton and phytoplankton of bangladesh waters.	vibrio cholerae serogroup o1, the causative agent of cholera, is capable of surviving in aquatic environments for extended periods and is considered an autochthonous species in estuarine and brackish waters. these environments contain numerous elements that may affect its ecology. the studies reported here examined physical interactions between v. cholerae o1 and natural plankton populations of a geographical region in bangladesh where cholera is an endemic disease. results showed that four of f ...	1990	2383016
[antibacterial and anti-hemolysin activities of tea catechins and their structural relatives].	among catechins tested, (-)epigallocatechin (egc), (-)epicatechin gallate (ecg), (-) epigallocatechin gallate (egcg) inhibited the growth of staphylococcus aureus, vibrio cholerae o1 classical inaba 569b and el tor inaba v86. s. aureus was more sensitive than v. cholerae o1 to these compounds. egcg showed also a bactericidal activity against v. cholerae o1 569b. pyrogallol showed a stronger antibacterial activity against s. aureus and v. cholerae o1 than tannic and gallic acid. rutin or caffein ...	1990	2381042
vibrio bacteremia in siriraj hospital.	from january 1983 to march 1988, 26 isolates of vibrio spp. were recovered from the blood of patients admitted to siriraj hospital. thirteen strains were identified as non 0-1 vibrio cholerae, 3 were vibrio vulnificus and 10 were vibrio spp. the medical records of 20 patients were available for clinical analysis. most of them were adult men with cirrhosis. clinical features included fever, abdominal pain, diarrhea, peritonitis, shock and skin lesions. some patients had a history of seafood consu ...	1990	2380645
use of a synthetic oligonucleotide probe to detect strains of non-serovar o1 vibrio cholerae carrying the gene for heat-stable enterotoxin (nag-st).	a synthetic oligonucleotide probe was developed to identify the gene for the heat-stable enterotoxin (nag-st) of non-serovar o1 vibrio cholerae. of 103 non-o1 v. cholerae isolates from thailand, 31 isolates from mexico, and 47 isolates from patients in the united states, only 7 (all from thailand) hybridized with the probe. probe-positive strains produced significantly higher fluid accumulations in infant mice than probe-negative strains.	1990	2380369
[excision of a splenic cyst using a surgical stapler in partial splenectomy].	the authors extirpated the splenic cyst of a young girl with the use of stapler in such a way that the distal part of the spleen was preserved. during this case the types of splenic preservative operations and the question of fulminant sepsis found in the patients went under splenectomy were surveyed. according to us the advantage of using stapler in partial splenectomy than the others is that firstly it is technically simple, less time consuming, and the haemostasis is safe. this is thought to ...	2007	2377359
[prevalence of type 1 human immunodeficiency virus (hiv) infection in african patients residing in catalonia].	278 black patients from west africa, living in maresme, a coastal area north of barcelona were studied in order to determine the prevalence of hiv-1 infection. during the first period (1984-86), 102 patients were studied, 3 of them were positive for hiv-2, but none was positive for hiv-1. in the second period (1987-89), 176 patients were studied and 15 were positive for hiv-1. sexual intercourse with prostitutes of low social level was the only risk factor in all of them. nine of these 15 patien ...	1990	2377013
lymphomas of mucosa-associated lymphoid tissue (malt).		2008	2376404
[diagnosis, incidence and clinical significance of premature lh rise/peak in patients of an in vitro fertilization and gamete transfer program].	in this study we analysed the prevalence and the clinical relevance of premature (related to the day of ovulation induction with hcg) lh rise (lh greater than or equal to 180%, but less than 300% of the mean of all previous values) or peak (lh greater than or equal to 300% of the mean of all previous values): 12% (2/16) of the conception cycles showed a premature lh peak, 44% (7/16) a premature lh rise and 44% (7/17) showed neither a premature lh rise nor a premature lh peak. the pregnancy rate ...	2007	2376305
indian health service: a dental student opens her heart to native americans.		2008	2376232
sigmoid volvulus in kaduna, nigeria.	worldwide regional variations exist in the incidence of sigmoid volvulus. this article describes the experience with sigmoid volvulus at the ahmadu bello university teaching hospital in kaduna, nigeria. sixty of 121 patients who had large-bowel obstruction over a 15-year period had sigmoid volvulus. fifty-seven (95 percent) had gangrenous bowel. the mortality rate was 16.7 percent. the clinical presentation and the treatment modalities offered are discussed.	2008	2376220
erotomania and senile dementia.		2008	2375449
[the morphofunctional characteristics of lymphoma nk/ly cells treated with concanavalin a and vibrio cholerae neuraminidase].	mouse nk/ly lymphoma cells were modified by con a or vibrio cholerae neuraminidase (vcn). severe damage of the modified cells was not revealed by either supravital staining or light microscopy. ultrastructural signs of metabolic lowering in the con-a-treated cells were determined. some increase in electrophoretic mobility of con-a-modified cells was found, along with its decrease in vcn-modified cells. the decrease in the pool of proliferating cells was determined in both the types of modificati ...	1990	2375060
a comparative study for fiberoptic and video endoscopic determination of the extent in minimal changes of gastric mucosa using indigo dye spraying.	the image resolution of fiberoptic and video endoscopy was compared in a series of patients with early gastric cancer. eighteen patients were divided into two groups. one group of patients (n = 9) was evaluated with fiberoptic endoscopy while the second group (n = 9) was evaluated using video endoscopy. the extent of cancer invasion, with special attention to size, shape and type of the lesions, was evaluated in each patient. attempts were also made to identify the proximal and distal limits of ...	2007	2374986
investigations of morning and laboratory dream recall and content in depressive patients during baseline conditions and under antidepressive treatment with trimipramine.	rem sleep abnormalities like shortened rem (rapid eye movement) latency, prolongation of the first rem period and heightening of rem density often found in patients with a major depression have prompted an increasing number of studies investigating the neurobiology and neurophysiology of rem sleep in depressive patients, as well as in healthy humans and animals. on the other hand, since the early 1970s investigation of the psychological concomitant of rem sleep, i.e., dreaming, in depressive pat ...	2008	2374795
cloning and nucleotide sequence of a cdna encoding the antifungal-protein of aspergillus giganteus and preliminary characterization of the native gene.		1990	2374718
effective discharge preparation of elderly cataract day surgery patients.	nurses should ensure that prior to discharge, cataract surgery patients acquire basic knowledge about the surgical procedure, postsurgical recovery, and safe, appropriate health-care practices during early convalescence. the modified knowledge test may be a functional, easy to administer tool to assess and track patient's knowledge about their post-cataract surgery recovery and safe, appropriate health-care practices during the early convalescent period. patients can acquire most of the requisit ...	2008	2374167
bacteria from solid tumours.	bacteria were grown from 63 (69%) of 91 specimens from necrotic tumours in 63 patients. of the tumours, 14 were abdominal, 5 pelvic, 23 of the head and neck, 4 of the lungs, 4 mediastinal, 2 lymphatic, 3 of the breast, and 8 were miscellaneous. aerobic or facultatively anaerobic bacteria only were present in 12 (19%) specimens, anaerobes only in 10 (16%), and mixed aerobic and anaerobic bacteria in 41 (65%). a total of 83 anaerobic and 47 aerobic and facultatively anaerobic bacteria were isolate ...	1990	2374159
the downfield resonances in the 1h nmr spectra of azotobacter vinelandii and pseudomonas putida seven-iron ferredoxins.	pseudomonas putida and azotobacter vinelandii ferredoxins each contain one [4fe-4s] cluster and one [3fe-4s] cluster. their polypeptide chains are nearly identical, differing by only 15 residues out of a total of 106. t1 measurements and temperature dependence studies of the 1h nmr spectrum of each ferredoxin demonstrate that all six resolved downfield resonances are near an iron-sulfur center. the five most downfield resonances are shown to arise from protons on cysteinyl beta-carbons by incorp ...	1990	2373698
temporal regulation of hyaluronan and proteoglycan metabolism by human bone cells in vitro.	osteoblasts elaborate a dynamic extracellular matrix that is constructed and mineralized as bone is formed. this matrix is primarily composed of collagen, along with noncollagenous proteins which include glycoproteins and proteoglycans. after various times in culture, human bone cells were labeled with [35s]sulfate, [3h] leucine/proline, or [3h]glucosamine and the metabolism of hyaluronan and four distinct species of proteoglycans (pgs) was assayed in the medium, cell layer, and intracellular po ...	1990	2373688
increasing spontaneous language in three autistic children.	a time delay procedure was used to increase spontaneous verbalizations of 3 autistic children. multiple baseline across behaviors designs were used with target responses, selected via a social validation procedure, of two spontaneous responses ("please" and "thank you") and one verbally prompted response ("you're welcome"). the results indicate gains across target behaviors for all children, with occurrence across other stimuli and settings. these gains were validated socially with 10 adults. fu ...	2002	2373659
[the laser wave--a current trend].		2002	2373617
[the equivalent resistance of intracerebral gold electrodes in human beings].		1990	2373308
glycosphingolipid expression on murine l1-fibrosarcoma cells: analysis of clonal in vivo and in vitro selected sublines with different lung colonisation potential.	the patterns of acidic and neutral glycosphingolipids (gsls) were examined in a syngeneic tumour system in balb/c mice consisting of closely related cell lines with different colonisation potentials directed to the murine lungs (in vivo selected highly metastatic sublines of l1-fibrosarcoma cells and their wga-resistant mutants with low metastatic potential). gsls were analysed by high-performance thin-layer chromatography and structurally identified by fast atom bombardment mass spectrometry co ...	1990	2372482
the cytolysin gene of vibrio vulnificus: sequence and relationship to the vibrio cholerae e1 tor hemolysin gene.	a cytolysin of ca. 56 kilodaltons has been suggested as a possible virulence factor in vibrio vulnificus infections. we sequenced the dna encoding cytolytic activity and found that the sequence contained two open reading frames, vvha and vvhb. vvha encoded the structural gene for the cytolysin and contained the n-terminal amino acid sequence previously reported for the protein. regions of the vvha gene showed homology to the structural gene for the vibrio cholerae e1 tor hemolysin.	1990	2370116
the response of serum growth hormone and prolactin to training in weight-maintaining healthy males.	resting levels of serum growth hormone (gh) and prolactin (prl) were measured pretraining, 3 weeks and 10 weeks posttraining in seven college age males. the exercise consisted of thrice weekly sessions at 70% vo2max for 20 minutes plus warmup and cool down. body weight remained constant during the ten week training period. however, body fat decreased significantly. resting daytime levels of gh decreased significantly with training while resting prl levels were unchanged. the hormone responses su ...	1976	2366534
[a clamp for securing bottles containing blood and blood substitutes].		1976	2366445
[ambulatory care and intensification of the rehabilitation of patients following reconstructive surgery on the major vessels].		1976	2366433
[the organization and extent of medical aid to burned patients in nonspecialized hospitals].		1976	2366432
the choice of surgical procedure in congenital, infantile, and juvenile glaucoma.	trabeculotomy is successful in patients with an angle anomaly involving only the trabecular meshwork, but in those involving the trabecular meshwork with iris and/or cornea trabeculotomy combined with trabeculectomy is recommended. in cases of failed trabeculotomy or trabeculectomy, a molteno implant can be tried, although it does not work well in patients with congenital glaucoma. if all else fails, a cyclodestructive procedure is indicated and contact nd:yag laser cyclophotocoagulation is reco ...	1974	2366246
the stereospecificities of seven dehydrogenases from acholeplasma laidlawii. the simplest historical model that explains dehydrogenase stereospecificity.	stereospecificities are reported for seven dehydrogenases from acholeplasma laidlawii, an organism from an evolutionarily distinct branch of life which has not previously been studied from a stereochemical point of view. three of the activities examined (alcohol dehydrogenase, lactate dehydrogenase, and alanine dehydrogenase) catalyze the transfer of the pro-r (a) hydrogen from nadh. four other activities (3-hydroxy-3-methylglutaryl-coa reductase, glyceraldehyde-3-phosphate dehydrogenase, glucos ...	1990	2365693
kinetics of "p"-site-mediated inhibition of adenylyl cyclase and the requirements for substrate.	the kinetics of "p"-site-mediated inhibition of adenylyl cyclase was studied with the detergent-solubilized enzyme from rat brain. mn2(+)-activated adenylyl cyclase exhibited typical noncompetitive inhibition by 2'-d3'-amp or 2',5'-dideoxyadenosine (2',5'-ddado). however, enzyme that was preactivated with guanosine 5'-o-(3-thiotriphosphate) (gtp gamma s) or proteolytically with ninhibin (+ gtp gamma s) exhibited apparently uncompetitive inhibition with either 2'-d3'-amp or 2',5'-ddado and with e ...	1990	2365688
intestinal cryptosporidiosis acquired from a cat.	a case of intestinal cryptosporidiosis in an eight-year-old boy is presented. the patient became ill during a visit to a farm where diarrhoea in newborn calves is a recurrent problem. furthermore, on that farm kittens periodically suffer from diarrhoea and failure to thrive. oocysts of cryptosporidium sp. were identified in the stool of the patient, and in the stool of the cat he had contact with. at that time the calves were not infected. the patient's gastrointestinal symptomatology consisted ...	1990	2365471
intestinal cryptosporidiosis acquired from a cat.	a case of intestinal cryptosporidiosis in an eight-year-old boy is presented. the patient became ill during a visit to a farm where diarrhoea in newborn calves is a recurrent problem. furthermore, on that farm kittens periodically suffer from diarrhoea and failure to thrive. oocysts of cryptosporidium sp. were identified in the stool of the patient, and in the stool of the cat he had contact with. at that time the calves were not infected. the patient's gastrointestinal symptomatology consisted ...	1990	2365471
morphology of endotoxin-like particles released by vibrio cholerae non-o1.	the morphology of "free endotoxin" in cell suspensions of vibrio cholerae non-o1 and in fractions purified from culture filtrate (fraction 1) was examined at the beginning of the exponential phase of growth in complex medium. the observed structures were compared with those of the lipopolysaccharide obtained by phenol extraction. blebs, vesicles, and ribbons with a trilaminar, membrane-like structure were observed by electron microscopy of ultrathin sections and negatively stained samples. endot ...	1990	2363795
neurocristopathy syndrome: review of four cases.	aberrant embryologic development of the neural crest may clinically result in one of several patterns of malformation. four examples of the neurocristopathy syndrome are described that collectively feature a very broad range of expression in these infants. because of the many expressions, the syndrome may not be recognized. we believe that greater familiarity with the disorder will aid in the discovery of unsuspected anomalies and provide clues about predisposing etiologies.	2008	2359735