Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| five groups of antigenic determinants on dna identified by monoclonal antibodies from (nzb x nzw)f1 and mrl/mp-lpr/lpr mice. | a library of monoclonal antibodies (mca) reactive with dna was derived from mice with lupus-like disease. the combining reactions of the antibodies was determined by elisa, precipitation assay and indirect immunofluorescence assay on cells. on the basis of their reactions in these assays, the mca have been classified into five taxonomic groups. mca in group i react with conformational determinants on double-stranded dna (dsdna); those in group ii with conformational backbone-dependent sugar-phos ... | 2008 | 2581889 |
| nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section. | the sciatic nerve was sectioned unilaterally in rats and nerve growth factor (ngf) applied locally to the nerve stump for the following 10-14 days using an indwelling osmotic pump. the aim of the experiment was to test whether ngf had any effect on the previously reported neurophysiological and neurochemical events that occur central to a peripheral nerve lesion. the method of application allowed the sciatic nerve on the other side to be used as a control. primary afferent depolarization fell, a ... | 1985 | 2581648 |
| leukocyte tubuloreticular inclusions in reye's syndrome. | tubuloreticular inclusions (tri) have been observed in the rough endoplasmic reticulum of blood lymphocytes and monocytes in two cases of reye's syndrome initiated by influenza infections. tubuloreticular inclusions are seen in these mononuclear leukocytes during the acute phase of illness, but not during convalescence. since tri have been demonstrated in peripheral mononuclear leukocytes in patients with acquired immunodeficiency syndrome, systemic lupus erythematosus, and certain viral infecti ... | 1985 | 2581524 |
| medium- and long-latency responses to displacements of the ankle joint in patients with spinal and central lesions. | in order to elucidate further the possible pathways and the functional significance of long-loop reflexes we recorded short-, medium- and long-latency responses from leg muscles in 27 patients with spinal lesions, 20 patients with central lesions of the internal capsule or cerebral hemisphere, and in 18 control patients with frontal or occipital lesions without motor or sensory disturbances. our normal population included 50 subjects, who were age and sex matched to the patients. the mean latenc ... | 2008 | 2580691 |
| [barium currents through single calcium channels of a nerve cell membrane]. | 2008 | 2580683 | |
| intestinal infection with mycobacterium avium in acquired immune deficiency syndrome (aids). histological and clinical comparison with whipple's disease. | at endoscopy, a 30-year-old man with acquired immune deficiency syndrome (aids), kaposi's sarcoma, diarrhea, and unexplained malabsorption showed erythematous macular duodenal lesions consistent with whipple's disease by histology and electron microscopy. symptoms did not respond to tetracycline. subsequent cultures revealed systemic mycobacterium avium (m. avium) infection. tissue from this patient, from patients with whipple's disease and from a macaque with m. avium were compared. all contain ... | 1985 | 2580679 |
| cloning and characterization of the hemolysin determinants from vibrio cholerae rv79(hly+), rv79(hly-), and 569b. | the hly region from the chromosome of vibrio cholerae el tor strain rv79(hly-) and the nonhemolytic classical strain 569b were cloned into plasmid vector pbr322. escherichia coli k-12 transformants possessing these recombinant plasmids were nonhemolytic and were detected with a 32p-labeled hly-specific dna probe. restriction endonuclease sau3ai digestions of the cloned hly loci of two independently obtained rv79(hly+) convertants, when compared with the digests of cloned rv79(hly-) loci, reveale ... | 1985 | 2579940 |
| rationale behind the development of low molecular weight heparin derivatives. | there is now considerable evidence that the antithrombotic and the hemorrhagic effects of heparin can be dissociated by using low molecular weight heparins and by using heparin with low affinity to at iii. the findings with low-affinity heparin suggest that hemorrhage is contributed to by heparin properties that are independent of at iii binding and thus of their major anticoagulant effect. the current evidence supports the suggestion that the hemorrhagic effect of heparin is contributed to by a ... | 1985 | 2579436 |
| [determination of antibodies to streptococcus group a polysaccharide in human sera by an immunoenzyme method]. | use was made of the elisa to develop a highly sensitive quantitative method for detection of antibodies against streptococcus group a polysaccharide (polysaccharide a) in human sera. the main advantage is that one can use only one optimal dilution of the sera together with the reference serum. sera of 53 healthy volunteers and 77 patients with a history of streptococcus group a infections were screened for the presence of polysaccharide a antibodies. highly reproducible results were obtained in ... | 1985 | 2578835 |
| [surgical indications in severe abnormalities with reference to the expected quality of life]. | an explanation of the term "quality of life" must consider the view of the person concerned, the view of the therapist and society. patients with mmc who have the prerequisites for a satisfactory quality of life are often unable to realize it in practice. prenatal diagnostics has not yet provided new indications for operation. the malformation in the seven last admitted children with mmc was not known before the 23rd week of pregnancy. a selection after birth is considered problematical. | 2008 | 2577667 |
| [results of synovectomy of the elbow joint in chronic polyarthritis]. | 2008 | 2576709 | |
| regression of left ventricular hypertrophy in hypertension with alpha-adrenergic blockade: physiological basis and therapeutic implications. | left ventricular hypertrophy may be a serious consequence of chronic untreated hypertension since it may accentuate the risk of congestive heart failure, arrhythmias, coronary ischaemias and sudden death. although haemodynamic factors may play a role in the genesis of left ventricular hypertrophy, certain neurohumoral mechanisms such as the adrenergic nervous system may induce left ventricular hypertrophy in patients with hypertension. there is considerable evidence to implicate adrenergic activ ... | 2008 | 2576672 |
| effect of urapidil on the performance of ischaemic myocardium in anaesthetized dogs. | the effect of urapidil on the ischaemic myocardium was studied in eight anaesthetized dogs. stenosis of the left descending coronary artery reduced blood flow and systolic contraction of the post-stenotic myocardium by about 50%; the end-diastolic length of the post-stenotic myocardium and the end-diastolic pressure increased, while aortic pressure slightly decreased. subsequent administration of urapidil (0.25 + 0.25 + 0.5 + 1.0 mg/kg intravenously) did not affect the systolic shortening and en ... | 1989 | 2576670 |
| additional benefits of combining beta-blockade and renal vasodilation in the treatment of mild to moderate hypertension: tertatolol international multicentre study results. | 2008 | 2576668 | |
| comparison of a vasodilating beta-blocker and a cardioselective beta-blocker in long-term treatment of hypertension: a european multicentre study. | the therapeutic effectiveness and safety of indenolol, a vasodilating beta-blocker with beta 2-agonism, was compared with that of atenolol, a cardioselective beta-blocker, in a 1-year double-blind trial. a total of 143 hypertensive patients (diastolic blood pressure 95-115 mmhg after 1 month of placebo) were randomly allocated to either atenolol, 50 mg/day, or indenolol, 60 mg/day. if the target diastolic blood pressure (less than or equal to 90 mmhg) was not reached after 1 month, the beta-bloc ... | 2008 | 2576667 |
| reduction of blood pressure in obese hyperinsulinaemic hypertensive patients during somatostatin infusion. | hypertension in the obese may be related to hyperinsulinaemia. to investigate this relationship further, we infused somatostatin (250 micrograms/h in 100 ml saline) or saline, single-blind and in a random order, for 10 h in seven obese hyperinsulinaemic hypertensive patients and in seven normo-insulinaemic hypertensive controls. every 2 h, blood pressure, plasma insulin, glucose, sodium, potassium, renin, cortisol and aldosterone concentrations and the urinary sodium:creatinine ratio were determ ... | 2008 | 2576663 |
| blood pressure rather than humoral factors regulate arterial wall trophicity in rats with an aortocaval fistula. | 1989 | 2576662 | |
| a family with an apparent hla-dr triplet: evidence for exchange of functional hla-dr beta-genes between different haplotypes. | serological and protein analysis showed that hla-dr1 and dr2 short (s) segregated together as one haplotype, resulting in a hla-dr triplet as found in a family study. both dr1 and dr2 molecules were coordinately expressed and were shown to function as restriction elements in antigen presentation assays. this unique hla-dr1, 2s haplotype was further studied by southern blot analysis. based upon well-known restriction fragment length polymorphisms for the involved gene sets, i.e. dr1 and dr2 along ... | 2008 | 2576521 |
| [possibilities of objective assessment of the course of activation in ideomotor training]. | an active exploration of movement tasks is accompanied with central nervous activation. its systematical examination needs a teamwork of scientists of various branches of knowledge (i.e. physiology, psychology, sport sciences). mental training (motor imagination - mi) was chosen as a model for such examinations. in connection with the execution of mi there are characteristic chances of the mean alpha frequency of the eeg, heart rate, respiration rate and skin conductance. the time course of thes ... | 2008 | 2576486 |
| the toxin-coregulated pilus (tcp) of vibrio cholerae: molecular cloning of genes involved in pilus biosynthesis and evaluation of tcp as a protective antigen in the infant mouse model. | a serum containing antibodies to non-lipopolysaccharide (non-lps) protective antigens of vibrio cholerae has been used, after extensive absorption, to facilitate the cloning of genes involved in the synthesis of toxin-coregulated pili (tcp). a gene bank was constructed from v. cholerae z17561 dna using a mobilizable cosmid vector in escherichia coli, and subsequently transferred by conjugation into v. cholerae o17. this strain does not produce tcp in vitro and lacks non-lps protective antigens. ... | 1989 | 2576091 |
| nucleotide sequence of the structural gene, tcpa, for a major pilin subunit of vibrio cholerae. | the toxin co-regulated pilus (tcp) of vibrio cholerae appears to be a major protective antigen. by cosmid cloning we have isolated a number of clones capable of converting tcp- el tor strains of v. cholerae to tcp+. a synthetic oligodeoxyribonucleotide probe based upon the n-terminal amino acid sequence of tcpa, has been used to localize the structural gene within the cosmid clones. using suitable subclones, the nucleotide sequence of the tcpa gene has been determined. the gene encodes a 23.3-kd ... | 1989 | 2576015 |
| central and peripheral actions of alpha 2-adrenergic agonists on renal function in long-evans and brattleboro rats. | the effects of 3 alpha 2-adrenergic receptor agonists on renal function in vasopressin (avp)-deficient brattleboro (di) rats were evaluated. the aim of this study was to determine the relative contribution of central versus peripheral alpha 2-adrenoceptors in mediating diuresis and natriuresis, as well as the role of alpha 2-adrenoceptors in antagonizing the actions of avp. in addition to the studies of renal function, the effects of avp deficiency on renal alpha 2-adrenoceptor affinity and numb ... | 1989 | 2575260 |
| modulation of a 190-kd microtubule-associated protein in pigment epithelium by vip. | vasoactive intestinal peptide stimulates phosphorylation of six high molecular weight cytosolic proteins in the cultured retinal pigment epithelium (rpe). of these, the 190-kd phosphoprotein is associated with the microtubules assembled by taxol/gtp and is immunologically related to the brain microtubule-associated protein 2 (mol.wt. = 280 kd). vip is also shown here to stimulate secretion in the cultured rpe. vip-stimulated phosphorylation of a 190-kd microtubule-associated protein is also demo ... | 2008 | 2575248 |
| gut size and the digestion of fibrous diets by tetraonid birds. | a series of diets containing different proportions of heather was fed to red grouse. heather is the bird's main natural food and contains much fiber; the rest of each diet was a relatively low-fiber, grain-based formulation. with increasing heather and associated fiber contents, food intake increased and overall digestibility of heather was only 9.4%, but, when heather was eaten as the sole food by wild red grouse, its digestibility was 46%. adaptations to diets containing more heather included ... | 2008 | 2575129 |
| mechanisms of action of slow-acting drugs in rheumatoid arthritis. | slow-acting anti-rheumatic drugs exhibit a number of similar properties in treated patients that suggest that they may have a common mode of action in rheumatoid arthritis. in vitro evaluation of drug action suggests that each of the slow-acting agents possesses immunosuppressive activity that may explain its therapeutic efficacy in rheumatoid arthritis. even though these agents appear to be able to suppress immune responses, the site of action of these agents differs. thus, gold compounds and t ... | 2008 | 2575024 |
| [method of isolating fmrf-amide-like substances in the snail, using affinity chromatography coupled with hplc]. | an extraction procedure of fmrfa-like substances from brain of helix aspersa was developed. it consists of using affinity chromatography coupled with reverse phase hplc. three synthetic peptides (fmrfa, pqdpflrfa, met-enkephalin) were used to evaluate the specificity and yield of the affinity column. its efficiency was tested by use of snail brain extracts. the results showed that this method is efficient and reproducible. | 2008 | 2575010 |
| the effects of h1 antihistamines on the early allergic response. | to increase understanding of the effect of h1 antihistamines on the immediate response to nasal challenge with antigen, we performed two double blind, placebo-controlled, crossover studies using cetirizine and terfenadine. the subjects underwent nasal challenge with antigen after premedication with either cetirizine (20 mg qd for two days, n = 10), terfenadine (60 mg bid for 1 week, n = 12), or placebo for equivalent periods of time. we monitored the response to challenge by counting the number ... | 2008 | 2574550 |
| unilateral akathisia. | 2006 | 2573863 | |
| tertatolol in hypertension. long-term therapy in 2,338 patients. | tertatolol has been studied in 2,338 patients with mild to moderate hypertension over a one year period. tertatolol (t) was initiated alone (5 mg once daily) and if satisfactory control of blood pressure (bp) (diastolic bp less than 95 mm hg) was not achieved, treatment was adapted at the third or sixth month either by increasing the dosage (heart rate greater than 70 beats/min), or by adding a potassium-sparing diuretic (heart rate less than or equal to 70 beats/min). blood pressure normalizati ... | 2008 | 2573378 |
| glutamine synthetase and glutaminase activities in various hepatoma cells. | glutamine synthetase and glutaminase activities in a series of hepatoma cells of human and rat origins were determined for comparison with normal liver tissues. marked decrease in glutamine synthetase activity was observed in the tumor cells. phosphate-dependent and phosphate-independent glutaminase activities were increased compared with those from normal liver tissues. well coupled mitochondria were isolated from huh 13 line of human hepatoma cells and human liver. oxypolarographic tests showe ... | 1989 | 2573354 |
| what the aircrew automated escape system and aircrew life support system equipment designers need from the investigating medical officer and pathologist. | a major problem apparent in many safety investigation reports concerning aviation mishaps, and especially in their component flight surgeon's reports (fsrs), is the failure of the investigators to recognize needs beyond those of their immediate organizational structures and chains of command in conducting the investigation, and reporting the resultant facts and findings. if aircrew losses and serious injuries are to be reduced, other needs must also be considered and addressed. these additional ... | 2008 | 2573335 |
| [takayasu arteritis: usefulness of radiologic and angiographic studies]. | with the purpose of learning the usefulness of radiologic and angiographic procedures for the evaluation of takayasu's arteritis (ta), we studied 64 patients (ratio women: 8.1, average age: 23.5 years, range: 13-52 years) in which we performed arteriographic studies in the clinically affected area. all cases had chest films: 53 had thoracic aortogram, 60 abdominal aortogram, 16 pulmonary arteriography. according to the topography of the lesions we found 8% of the cases with damage exclusive to t ... | 2008 | 2573321 |
| [seminoma in the undescended testis]. | maldescend testes are predisposed to tumor degeneration from embrional germinal dysgenesis, the cause of cryptorchidism. the risk of carcinogenesis is thirty to fifty times greater than in normal descended testes. the histologic features of this tumor type and its treatment do not differ from those of normotopic tumors. | 2008 | 2573318 |
| [persistent mullerian duct syndrome]. | we report on a 14-year-old boy who was admitted to the emergency department for acute retention of urine. at age 1 year, he had been submitted to surgery for left cryptorchidism and left-sided herniation, associated with hypospadias of the glans penis. radiologic and endoscopic work up revealed a large retrovesical cavity with septation in its upper portion communicating with the prostatic urethra. these structures were removed and pathologic examination disclosed remnants of müllerian ducts. th ... | 2008 | 2573317 |
| significance of toxin-coregulated pili as protective antigens of vibrio cholerae in the infant mouse model. | the infant mouse cholera model has been used to evaluate the relative importance of toxin-coregulated pili (tcp) as protective antigens of vibrio cholerae 01. electron microscopic and immunoblotting analyses revealed that, under the cultural conditions examined, tcp were only expressed by strains of classical biotype. antibodies to tcp were sufficient to confer protection against two such strains, and were more efficient if the challenge vibrios were cultured for tcp expression. in contrast, suc ... | 1989 | 2573216 |
| modulation of transmitter and hormone release by multiple neuronal opioid receptors. | 1989 | 2573137 | |
| [pharmacologic therapy of bronchial asthma]. | the main feature in asthma is bronchial eosinophilic inflammation, induced, in genetically predisposed subjects, by known (aeroallergens, viral infection, occupational agents) and unknown agents. inflammation critically increases bronchial responsiveness so that even rather mild stimuli (exercise, cold air, mist, allergens) are able to induce obstructive reactions. when preventive measures (specific immunotherapy, avoidance of inflammatory and precipitating factors) are inadequate, a pharmacolog ... | 2008 | 2573115 |
| dopamine- and camp-regulated phosphoprotein (darpp-32) and dopamine da1 agonist-sensitive na+,k+-atpase in renal tubule cells. | the cellular localization of darpp-32, a dopamine- and camp-regulated phosphoprotein of mr 32,000 that appears to mediate certain actions of dopamine in the mammalian brain by acting as an inhibitor of protein phosphatase 1, was studied in the kidney of several species. darpp-32 mrna and darpp-32-like immunoreactivity were found in the cytoplasm of cells in the thick ascending limb of the loop of henle. the specific dopamine da1 agonist skf 82526 caused a dose-dependent inhibition of na+,k+-atpa ... | 1989 | 2573060 |
| the role of neuronal energy in the neurotoxicity of excitatory amino acids. | excitatory amino acids, acting at receptors such as the n-methyl-d-aspartate (nmda) subtype, are good candidates for a major role in the neuronal death characteristic of alzheimer's disease. recent evidence from studies with cultured neurons suggests that perturbations in the energy metabolism of the neuron may be involved in the transition of nmda agonists from neurotransmitters to neurotoxins via a mechanism that involves relief of the voltage-dependent mg++ block of the nmda channel. | 2008 | 2572985 |
| [immunoactive cells in endometrial tissue in various phases of the female ovulatory cycle]. | 2008 | 2572203 | |
| the cardiovascular effects of vecuronium during halothane anaesthesia. | in a double-blind, placebo-controlled, prospective randomized trial in 70 otherwise healthy patients undergoing elective surgery of the thyroid gland, the breast, the inguinal canal or the lower limbs, we studied the cardiovascular effects of vecuronium during halothane-nitrous oxide anaesthesia. vecuronium was found to have no clinically significant influence on heart rate or mean arterial pressure, before or during surgery. bradycardia was a rare event under the special conditions of the study ... | 2005 | 2572136 |
| hydrogen peroxide mutagenicity towards salmonella typhimurium. | in bioassays conducted under controlled, comparable conditions, weak direct mutagenicity responses were observed for hydrogen peroxide in the standard (ames test) agar plate incorporation bioassay with salmonella typhimurium strains ta97, ta98, ta102, and ta1537, in a 20 min preincubation test with strains ta97, ta98, ta100, ta102, ta1537, and ta1538, and in a liquid incubation modification using strain ta1537. these results conclusively demonstrate that hydrogen peroxide is a weak mutagen, espe ... | 1989 | 2572065 |
| effects of sch23390 injection into the dorsal striatum and nucleus accumbens on methamphetamine-induced gnawing and hyperlocomotion in rats. | the effects of sch23390, a selective d1 receptor antagonist, injected into either the dorsal striatum or nucleus accumbens on methamphetamine-induced stereotyped gnawing and hyperlocomotion in rats were investigated. sch23390 injected into the dorsal striatum did not alter the gnawing induced by both methamphetamine and apomorphine. however, sch23390 injected into the nucleus accumbens significantly reduced methamphetamine-induced gnawing without altering the effects of apomorphine. injection of ... | 1989 | 2570826 |
| similarities in the repair kinetics of sublethal and potentially lethal x-ray damage in log phase chinese hamster v79 cells. | we have compared the repair kinetics of x-ray-induced sublethal damage (sld) and potentially lethal damage (pld) in v79 cells during postirradiation incubation in growth medium at 37 degrees c. kinetics of sld repair were studied by dose fractionation (d1 + d2 = 2 + 2, 4 + 2, 4 + 4, 10 + 4 and 10 + 7 gy). kinetics of pld repair were studied by incubating cells with 0.5 m hypertonic saline (hs) for 20 min at various times after irradiation. the repair of sld, after 2, 4 and 10 gy, was complete in ... | 2008 | 2570810 |
| influence of egg production on zinc, copper and iron metabolism in the turkey hen (meleagris gallopavo). | 1. serum concentrations of zinc, copper, iron, calcium and protein increased significantly with the onset of egg production in turkey hens. 2. hepatic concentrations of zinc, copper and iron declined significantly with the onset of egg production, whereas the total hepatic content of zinc and copper increased significantly. 3. when plasma from laying and nonlaying hens was subjected to gel-permeation column chromatography, a high molecular weight protein fraction was detected in laying but not i ... | 1989 | 2570667 |
| enterohepatic circulation of opioid drugs. is it clinically relevant in the treatment of cancer patients? | 2008 | 2570655 | |
| haemodynamic responses to acute blood loss: new roles for the heart, brain and endogenous opioids. | information has come forward recently from several sources which provides new insights into the mechanisms that underlie the haemodynamic responses to acute blood loss. in unanaesthetised animals and human volunteers there are two distinct phases to these responses. at first, the engagement of baroreflexes results in a progressive rise in sympathetic vasoconstrictor drive and peripheral resistance, and the maintenance of arterial blood pressure at a near-normal level. when about one-third of blo ... | 1989 | 2570536 |
| interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos. | the expression of the xenopus homoeobox gene xhox3 is an early response to mesoderm induction by peptide growth factors and the level of xhox3 expression marks the antero-posterior character of the induced mesoderm. different peptide growth factors specify different antero-posterior mesodermal cell fates as seen by the level of xhox3 expression and the capacity to induce specific secondary neural/epidermal structures. these factors and homoeobox genes thus form part of the mechanism necessary fo ... | 2008 | 2570357 |
| panic attacks, buspirone, and serotonin function. | 2008 | 2570299 | |
| campylobacter pylori, gastrin, acid secretion, and duodenal ulcers. | 1989 | 2570297 | |
| gut perforation after infection with herpes simplex virus and epstein-barr virus. | 1989 | 2570271 | |
| guidelines for the prevention and control of nosocomial h.i.v. infections. the hospital infection control group of thailand. | 1989 | 2570116 | |
| molecular epidemiology of vibrio cholerae in hong kong. | we studied restriction fragment length polymorphism of the enterotoxin genes of isolates of vibrio cholerae el tor, indistinguishable by bacteriophage typing, which were collected in hong kong since 1978. using this approach, we could distinguish indigenous and exogenous strains obtained from different sources and epidemiological settings. | 1989 | 2570082 |
| syntheses of the metabolites of 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-1h benzimidazole difumarate (kg-2413) and related compounds. | the metabolites of 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-1h-b enzimidazole difumarate (kg-2413), which has a potent h1-antihistaminic activity, were predicted on the basis of metabolic studies of related compounds and were synthesized to aid in identification of the actual metabolites and for examination of their antihistaminic activity. among the twelve compounds prepared, nine compounds were actually found as the metabolites of kg-2413 in rat urine. the antihistaminic a ... | 1989 | 2569942 |
| cloning and structural characterization of the genes coding for adenosylcobalamin-dependent methylmalonyl-coa mutase from propionibacterium shermanii. | the structural genes coding for both subunits of adenosylcobalamin-dependent methylmalonyl-coa mutase from the gram-positive bacterium propionibacterium shermanii have been cloned, with the use of synthetic oligonucleotides as primary hybridization probes. the genes are closely linked and are transcribed in the same direction. nucleotide sequence analysis of 4.5 kb of dna encompassing both genes allowed us to infer the complete amino acid sequence of the two subunits: the beta-subunit is the pro ... | 1989 | 2569861 |
| priapism: current concepts. | the treatment options for the management of the patient with priapism have changed markedly within the past several years. when possible, the underlying cause of the priapism should be identified. therapy should be guided by the results of aspiration of the blood-filled corpora cavernosa of the erect penis. early intervention through pharmacologic manipulation or surgical shunting should not be delayed while trying conservative measures. | 2001 | 2569852 |
| priapism: current concepts. | the treatment options for the management of the patient with priapism have changed markedly within the past several years. when possible, the underlying cause of the priapism should be identified. therapy should be guided by the results of aspiration of the blood-filled corpora cavernosa of the erect penis. early intervention through pharmacologic manipulation or surgical shunting should not be delayed while trying conservative measures. | 2001 | 2569852 |
| simultaneous outbreaks of contrasting drug resistant classic and el tor vibrio cholerae o1 in bangladesh. | 1989 | 2569589 | |
| duodenal bulb acidity and the natural history of duodenal ulceration. | fasting and post-prandial duodenal bulb ph was recorded in 10 subjects with untreated duodenal ulcers (du), 10 subjects with healed du, and 15 healthy volunteers. during fasting, ph was less than 4 for a greater percentage of time in healed than in active du. ingestion of a solid test meal accentuated this difference: subjects with active du and controls both showed less bulb acidification than subjects with healed ulcers. bulb ph was similar in patients with active ulceration and controls. the ... | 2008 | 2567869 |
| pili of vibrio cholerae o1 biotype e1 tor: a comparative study on adhesive and non-adhesive strains. | pili were found on the cell surface of non-adhesive vibrio cholerae o1 biotype e1 tor as well as the adhesive strain. purified pili of the adhesive and non-adhesive strains were morphologically, electrophoretically, and immunologically, indistinguishable from each other. the molecular weights of both pilin (subunit protein of the pilus) were about 16,000 daltons as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. these 16 kda pili are different from the pilus colonization ... | 1989 | 2567485 |
| effects of dopamine receptor activation on the level of cyclic amp in the trabecular meshwork. | we examined the effects of dopamine and of a selective da1 agonist, fenoldopam, on the levels of cyclic amp in the trabecular meshwork, freshly excised from porcine and canine eyes. as measured by radioimmunoassay, fenoldopam at a concentration of 10(-5) m caused a 4-fold increase in the cyclic amp content, from a basal level of 24.4 +/- 1.9 to 101.8 +/- 6.3 pmol/mg protein, of the trabecular meshwork samples from porcine eyes. in tissue samples from canine eyes, fenoldopam at a concentration of ... | 1989 | 2567286 |
| the relationship of symptomatology and medication to electrodermal activity in schizophrenia. | an electrodermal assessment procedure using mild innocuous tones, task-relevant tones, and loud white noise was administered to a sample of schizophrenic patients (n = 77). the present study investigated the relationship of schizophrenic symptomatology and anticholinergic level of neuroleptic medication to electrodermal variables. each patient was evaluated for positive (florid) and negative (defect) symptoms. the neuroleptics that patients received were rated according to their anticholinergic ... | 2008 | 2567035 |
| skin cancer among atom bomb survivors. | 2008 | 2566809 | |
| incorporation of monoclonal antibodies into cells by osmotic permeabilization. effect on cellular metabolism. | incorporation of asparagine synthetase-specific monoclonal antibodies into l5178y d10/r (l-asparaginase-resistant) murine lymphoma cells by osmotic lysis of pinocytic vesicles was used to evaluate the potential of the technique for macromolecular incorporation for metabolic studies. nonspecific effects of the incorporation procedure included temporary inhibition of protein and dna synthesis by 80-85% and a transitory loss of membrane integrity. cells incorporated with an antibody inhibitory to t ... | 2008 | 2566602 |
| seasonal population changes and malaria transmission potential of anopheles pharoensis and the minor anophelines in mwea irrigation scheme, kenya. | a study in 1984 and 1985 showed that anopheles gambiae s.l. and an. pharoensis were the major anophelines in mwea irrigation scheme, kenya, constituting 83.86% and 15.69% of the catch respectively. four minor species made up the remaining 0.45%. the irrigation phase of the rice cultivation cycle in august, which linked the flooding effects of the two rainy seasons, resulted in major population increases of an. pharoensis and enabled continuous breeding for up to 9 months per year. the average of ... | 1989 | 2566271 |
| [amino acid reserves of the blood in patients with schizophrenia and their correction in insulin coma]. | free amino acid content was measured in the blood serum in patients with permanently progressive paranoid schizophrenia under conventional insulin shock therapy. the influence of several amino acids (methionine, glutamic acid) preinjection on their base levels was also assessed. metabolic response to the insulin coma was different in preinjected vs. control groups. glutamine acid-preinjected patients displayed less pronounced shifts in amino acid reserves in the blood serum that smoothed the sho ... | 2008 | 2566218 |
| weight gain associated with psychotropic drugs. | the weight increase that is an often reported side effect of psychotropic drug use has implications for health risks as well as medication noncompliance. in this article i review the literature on the association between the use of several classes of psychotropic drugs and weight gain, discuss the possible mechanisms for this effect, and offer some practical approaches for reducing the risk of drug-induced weight gain, including the identification of a group of patients "at risk." | 2008 | 2566204 |
| [the correct use of beta 2 stimulants]. | 2008 | 2566197 | |
| neuropeptides in alzheimer's disease: a postmortem study. | the concentration of 5 neuropeptides, neurotensin (nt), somatostatin (srif), corticotropin-releasing factor (crf), bombesin and thyrotropin-releasing hormone (trh) was measured in 3 cerebrocortical areas and several subcortical regions in post-mortem brains obtained from patients with histologically verified alzheimer's disease and from controls without neurological or psychiatric disorders using sensitive and specific radioimmunoassay procedures. in alzheimer's disease, reductions in the concen ... | 2008 | 2566190 |
| pharmacokinetic study of iminodibenzyl antipsychotic drugs, clocapramine and y-516 in dog and man. | the pharmacokinetic properties of the iminodibenzyl antipsychotic drugs clocapramine (ccp, 3-chloro-5-[3-(4-carbamoyl-4-piperidino piperidino) propyl]-10, 11-dihydro-5h-dibenzo[b, f]azepine) and y-516 (3-chloro-5-[3-(2-oxo-1, 2, 3, 5, 6, 7, 8, 8a-octahydroimidazo [1,2-a] pyridine-3-spiro-4'-piperidino) propyl]-10, 11-dihydro-5h-dibenzo[b, f]azepine) were investigated in dog and man. dogs were administered ccp and y-516 intravenously, intraperitoneally, and orally, and the concentrations of the p ... | 1989 | 2566185 |
| low frequency of erythromycin-resistant streptococcus pneumoniae in the netherlands. | 1989 | 2566090 | |
| non-invasive evaluation of hemodynamic, tremorogenic and biochemical effects in response to beta-adrenoceptor stimulation. | 1, 4, 12 and 24 micrograms som 1397 cl, a new beta 2-adrenergic bronchodilator, were administered by inhalation to 10 healthy volunteers in a double-blind, placebo-controlled, within-subject crossover study in order to assess circulatory, tremorogenic and biochemical effects. 1 microgram som 1397 cl did not cause any relevant changes in the measured parameters. after administration of 4 micrograms a slight but continuous increase in tremor amplitude and c-amp was observed. the effects on hemodyn ... | 2008 | 2565995 |
| in-vivo effects of (e)-2-(3',4'-dimethoxyphenyl)-3-fluoroallylamine (mdl 72145) on amine oxidase activities in the rat. selective inhibition of semicarbazide-sensitive amine oxidase in vascular and brown adipose tissues. | one hour after mdl 72145 ((e)-2-(3',4'-dimethoxyphenyl)-3-fluoroallylamine) (2.5 mg kg-1) was given by intraperitoneal injection, the semicarbazide-sensitive amine oxidase (ssao) activity of rat aorta and brown adipose tissue measured in-vitro was reduced by more than 95% of its control value, whereas the monoamine oxidase (mao-a) activity remained virtually unaffected. the action of this drug on amine oxidases in the liver at this dose was less selective. the in-vitro effect of mdl 72145 on the ... | 1989 | 2565962 |
| effect of psoralens and ultraviolet radiation on murine dendritic epidermal cells. | monofunctional psoralens produce less phototoxicity than bifunctional psoralens after ultraviolet a (uva) irradiation. we investigated the effect of repetitive treatments with angelicin (isopsoralen), a monofunctional psoralen, plus uva radiation (ipuva) on the number and morphology of dendritic epidermal cells (dec). this effect was compared with that of 8-methoxypsoralen plus uva radiation (puva), uva alone, and uvb radiation. c3h/hen mice were treated topically with the drugs three times/wk f ... | 2008 | 2565931 |
| bronchial and cardiovascular effects of ocular topical b-antagonists in asthmatic subjects: comparison of timolol, carteolol, and metipranolol. | b antagonists eye drops are most effective for the treatment of chronic open angle glaucoma. by this way of administration they have a very good systemic bioavailability. bronchial, and cardiovascular effects of three of these topicals: timolol, carteolol and metipranolol have been evaluated in three parallel groups of asthmatic patients. the three topics induce bronchoconstriction without significant difference between them, and lower heart rate (sometimes very intensely) whatever the b antagon ... | 2008 | 2565918 |
| malignant ovarian tumors associated with pregnancy: report of six cases. | six cases of pregnancy associated malignant ovarian tumors, four epithelial cancers, one immature teratoma and one metastatic cancer of colon origin, are reported. one patient with mucinous cystadenocarcinoma had a history of persistent ovarian tumor during her past three pregnancies. another patient was found to have mucinous cystadenocarcinoma after an emergency operation for twisted ovarian tumor. immature teratoma associated with pregnancy is very rare and our case seems to be the 8th report ... | 2008 | 2565833 |
| cholera and contagion. | 1989 | 2565470 | |
| effects of neuraminidase on the regulation of erythropoiesis: iii: characterization of carbohydrate moieties on the surface of thymic regulatory cells that interact with erythroid colony-forming cells. | in this study we further define cell surface carbohydrate structures relevant to cellular interactions that regulate erythropoiesis. an analysis of thymocyte cell surface negativity was made using fluoresceinated poly-l-ornithine (fitc poly-l-ornithine) as a probe that binds to negatively charged sites (i.e., sialic acid residues) at the cell surface. two distinct subpopulations are labeled, comprising both intensely as well as weakly fluorescent subpopulations of thymocytes. prior treatment of ... | 1989 | 2565244 |
| somatostatin in the treatment of acute pancreatitis: a prospective randomised controlled trial. | a prospective study was carried out to evaluate the efficacy of somatostatin in the treatment of acute pancreatitis. seventy one patients were randomised to control (h = 36), or to the somatostatin group (h = 35) who received somatostatin 100 micrograms/h after a 250 microgram bolus for the first two days. the following were compared in the two groups on admission and two days later: laboratory tests of prognostic significance, severity of pancreatitis, and also morbidity and mortality. of the n ... | 2008 | 2564834 |
| a role of carbohydrate-carbohydrate interaction in the process of specific cell recognition during embryogenesis and organogenesis: a preliminary note. | a possible role of cell surface glycoconjugates in cell recognition has been envisioned based on recognition of carbohydrates by cell surface proteins such as endogenous lectins, glycosyltransferases, and hydrolases (refs. 18-22 in text). a new possibility that a specific carbohydrate at the cell surface could be recognized by the same or similar carbohydrate on the counterpart cell surface is now suggested by specific interaction between lex and lex, but not between lex and sialylated or non-su ... | 2006 | 2563943 |
| effects of in vivo neuraminidase on the regulation of erythropoiesis. ii: modulation of erythroid colony formation by thymic regulatory cells. | effects of the enzyme vibrio-cholerae neuraminidase (vcn) on the marrow-derived erythropoietic progenitor cfu-e and thymic regulatory cells were examined in vitro 1 and 24 h after i.v. injection of the enzyme. an in vivo enzymatic modification of bone marrow and thymic helper regulatory cell function occurs within 1 h after i.v. injection of vcn and results in suppression of both cfu-e colony formation and thymic helper cell function. these inhibitory effects of neuraminidase, however, are no lo ... | 1989 | 2563245 |
| absence of dystrophin in becker muscular dystrophy. | 2008 | 2563029 | |
| vecuronium infusion requirements in pediatric patients during fentanyl-n2o-o2 anesthesia. | eighty-one pediatric patients, ranging from neonates to adolescents, were studied during fentanyl-n2o-o2 anesthesia to determine for each of them the vecuronium infusion required to maintain 90-95% neuromuscular block (nmb). electromyographic monitoring with train-of-four stimuli was used. the steady infusion rate was 62 +/- 15 (sd) micrograms.kg-1.hr-1 in neonates and infants. this rate was 40% of that required by children 3 to 10 years old (154 +/- 49 micrograms.kg-1.hr-1; p less than 0.05). i ... | 2007 | 2562909 |
| conserved sequences in bacterial and viral sialidases. | the genes of the bacterial sialidases from clostridium sordellii g12, c. perfringens a99, salmonella typhimurium lt-2 and vibrio cholerae 395 sequenced so far were examined for homologies and were compared with sequences of viral sialidases. each of the bacterial sialidases contains a short sequence of twelve amino-acids, which is repeated at four positions in the protein. all these sequences exhibit significant similarities. comparing the repeated sequences of the four sialidases, five amino-ac ... | 1989 | 2562507 |
| successful bridge to transplant under extreme conditions: implanting left ventricular assist device in intensive care unit during heart massage. | 1989 | 2562142 | |
| effects of trh on the immune system of newborn rats. | 1989 | 2561202 | |
| concept of the existence of human papillomavirus (hpv) dna in histologically normal squamous epithelium of the genital tract should be re-evaluated. | because of the crucial importance of guiding current thinking in the field of hpv epidemiology, the concept of the existence of hpv dna in histologically normal squamous epithelium was re-evaluated. a series of 102 randomly collected cervical punch biopsies, previously proved to contain the dna of hpv types 6, 11, 16, 18, 31 or 33 by in situ hybridization were subjected to analysis for the localization of hpv dna, i.e., whether found in the normal epithelium or at the lesion site only. this mate ... | 1989 | 2561041 |
| [acute maternal anterior poliomyelitis in a non-endemic zone]. | the authors report the case of a 26 year old woman with acute anterior poliomyelitis contracted during the vaccination of her baby. despite having been herself vaccinated in infancy she was not protected against the poliovirus. the clinical interest of this uncommon case is a severe paralytic state with definitive paraplegia. the authors suggest serologic testing of patients born before 1967 especially if they are at risk of encountering the virus. | 1989 | 2561040 |
| calcium and sodium transport in gestational hypertension. | the enzymatic activities of na+/k+ atpase and ca2+ atpase were determined on erythrocyte membranes from 9 normotensive and 9 gestational hypertensive pregnant women near term. a reduction in the activity of the na+/k+ atpase and a relative increase in the activity of the ca2+ atpase were found in the hypertensive patients, possibly due to a conformational alteration of erythrocyte membranes. this observation supports the possible role of the transmembrane cation transport in the pathogenesis of ... | 2008 | 2559895 |
| families of bacterial signal-transducing proteins. | bacteria can respond to a variety of environmental stimuli by means of systems generally composed of two proteins. the first protein (sensor or transmitter) is usually a transmembrane protein with cytoplasmic and extracytoplasmic domains. the extracytoplasmic domain (sensor) senses the environment and transfers the signal through the transmembrane domain to the cytoplasmic domain (transmitter), which has kinase activity. the second protein is located in the cytoplasm and contains an amino-termin ... | 1989 | 2559300 |
| the site of bluetongue virus attachment to glycophorins from a number of animal erythrocytes. | bluetongue virus (btv) was shown to agglutinate human, ovine and porcine erythrocytes. removal of neuraminic acid (na) from erythrocytes by vibrio cholerae neuraminidase prevented their agglutination. haemagglutination was also inhibited by n-acetyl neuraminic acid (nana), n-glycol neuraminic acid (ngna) and n-acetyl neuramin-lactose. the ability of btv to agglutinate trypsin-treated human erythrocytes, which lack the amino-terminal domain and the single n-linked oligosaccharide of glycophorin a ... | 1989 | 2558161 |
| destabilization of herpes simplex virus type 1 virions by local anesthetics, alkaline ph, and calcium depletion. | the infectivity of herpes simplex virus type 1 (hsv-1) was found to be markedly reduced by treating virions with the tertiary amine local anesthetics lidocaine, dibucaine and tetracaine. these treatments induced a characteristic shift in the buoyant density of the hsv-1 particles from a "light" to a "heavy" population. hsv-1 virions were unstable at alkaline ph, and alkali treatment caused the same shift in buoyant density. ca2+ stabilized the "light" population. these results suggest that the p ... | 1989 | 2556981 |
| isolation and characterization of a putative collagen receptor from staphylococcus aureus strain cowan 1. | in a previous study we demonstrated that cells of staphylococcus aureus strain cowan bind 125i-collagen in a receptor-ligand type of interaction (speziale, p., raucci, g., visai, l., switalski, l.m., timpl, r., and höök, m. (1986) j. bacteriol. 167, 77-81). in the present communication we report on the isolation and preliminary characterization of a putative collagen receptor from a lysate of s. aureus strain cowan. antibodies raised against a collagen receptor positive strain inhibit the bindin ... | 1989 | 2556392 |
| effect of glucocorticoids and limiting nursing on the carbohydrate digestive capacity and growth rate of piglets. | the influence of glucocorticoid administration and limited nursing on piglet carbohydrase enzyme development and subsequent growth was examined in three experiments using 371 piglets. treatments in the first two experiments were formed by the factorial arrangement of hydrocortisone (-hyd or +hyd) and limited nursing (-ln or +ln) imposed form d 14 to weaning (d 28). hydrocortisone was replaced by adrenocorticotropic hormone (acth) in the third experiment. growth rates were severely depressed by h ... | 1989 | 2556355 |
| adult wilms' tumor. role of combined modality treatment. | adults wilms' tumor, unlike its pediatric counterpart, is extremely rare and highly lethal. less than 200 cases have been reported in the world literature and a large proportion of these may not have been true wilms' tumors. we report 3 cases seen at our institution who were treated with a multimodality approach, all three remaining alive without evidence of active disease at 6 years, 2.25 years and 8 months respectively from diagnosis. we also review results of multimodality management, emphasi ... | 2007 | 2556167 |
| [the dynamic characteristics of regional muscle blood flow and the activity of mineralization processes in the bony callus with various methods of treating mandibular fractures]. | rmbf was comparatively assessed in patients with lower jaw fractures under orthopedic therapy of the osteal suture. to this end, the 99m pertechnetate was injected bilaterally in masseter muscles. the data suggest that double jaw fixation had an adverse effect on rmbf, especially ipsilateral to the fracture. nevertheless, the mineral metabolism intensity in the callus is higher under fixation as related to the cases surgically sutured. | 2008 | 2555937 |
| free radicals and lipid peroxidation in liver of rats kept on a diet devoid of choline. | rodents kept on a choline devoid (cd) diet up to 14 months develop hepatic lesions progressing through two broad stages. the first is characterized by severe steatosis and increase in cell turnover, the second by a gradual clearance of the deposited fat and fibrosis. hepatocellular carcinomas eventually arise in rats fed for over 12 months, even though the animals aer not exposed to chemical carcinogens. it has been suggested that the diet may trigger generated thereby may be responsible for ini ... | 1989 | 2555277 |
| [detection of new genes participating in the trans-regulation of locus yellow of mdg-4 in drosophila melanogaster]. | the aim of the present work was to obtain mutations in the genes involved in regulation of the yellow locus and mdg4. for this purpose, we searched for mutations changing phenotypic expression of the y(2) mutation induced by mdg4 insertion into the regulatory region of the yellow locus. mutations have been obtained in the earlier described system of prolonged genome instability, sometimes combined with p-m hybrid dysgenesis. the mutation mod(mdg4) in a novel gene, modifier of mdg4, was detected ... | 1965 | 2555256 |
| ultrasonic doppler studies of hepatocellular carcinoma and comparison with other hepatic focal lesions. | one hundred fifty-four liver lesions, including 63 hepatocellular carcinomas, were studied to determine the value of duplex ultrasound in the diagnosis of small hepatocellular carcinomas. arterial doppler signals were obtained either within the body of the tumor, at its periphery, or in both locations, from 28 to 37 hepatocellular carcinomas less than or equal to 3 cm in diameter and from all 26 hepatocellular carcinomas with a diameter greater than 3 cm. arterial doppler signals were obtained a ... | 1965 | 2555245 |
| suppression of calcium current in a snail neurone by eperisone and its analogues. | the effects of eperisone, tolperisone and isoperisone on the calcium current (ica) were studied in an identified neurone of achatina fulica under voltage clamping. at a holding voltage of -50 mv, these drugs inhibited ica dose dependently without affecting activation time. eperisone (ic50 = 0.348 mm) and isoperisone (0.226 mm) were significantly more effective than tolperisone (1.089 mm). eperisone binds competitively with ca2+ to the ca2+ channels, based on its effects seen with various extrace ... | 1989 | 2555204 |