Publications

links between clinical and experimental neuropsychology.	the goals of both experimental and clinical neuropsychology involve qualitative analyses of the behavioral sequelae of brain damage in humans. both of these subdisciplines attempt to delineate and clarify perceptual, cognitive, linguistic, affective, and other changes in individuals with neurological disease--particularly as these disorders contribute to our understanding of normal brain function and its modification by pathology. thus, an interest in brain-behavior relations is coupled with dia ...	2009	2668327
purification, crystallization, and preliminary x-ray diffraction studies of the flavoenzyme mercuric ion reductase from bacillus sp. strain rc607.	the flavoenzyme mercuric ion reductase from bacillus sp. strain rc607 was purified by dye-ligand affinity chromatography. the protein was crystallized from solutions of high ionic strength, and one of the two crystal forms obtained has proven suitable for x-ray diffraction studies. preliminary analysis showed that these crystals belong to the tetragonal space group 1422. the unit cell dimensions are a = b = 180.7 a; c = 127.9 a. the diffraction pattern extends to better than 3 a resolution. crys ...	1989	2668287
sulfonylurea binding to adipocyte membranes and potentiation of insulin-stimulated hexose transport.	we have previously shown that the sulfonylureas increase insulin-stimulated glucose transport in adipocytes mainly by enhancing the insulin-induced recruitment of glucose transporter from its intracellular storage pool to the plasma membrane (jacobs, d. b., and jung, c. y. (1985) j. biol. chem. 260, 2593-2596). in order to determine if this sulfonylurea effect is mediated by a specific membrane-associated sulfonylurea-binding protein, in the present report we measured exact dose dependence of th ...	1989	2668270
purification and characterization of a protease produced by vibrio cholerae non-o1 and comparison with a protease of v. cholerae o1.	a protease produced by a clinical isolate of vibrio cholerae non-o1 was purified to apparent homogeneity by ammonium sulfate fractionation and successive column chromatography on deae-sephadex a25, sephadex g100, mono q, and phenyl superose. like the hemagglutinin-protease of v. cholerae o1, the purified protease had both hemagglutinating and proteolytic activities. the protease was heat labile, and in contrast to crude preparations, no arrhenius effect was observed with the purified protein. im ...	1989	2668188
[extracorporeal lithotripsy of gallbladder calculi with piezoelectrically generated shock waves: initial experiences].	a piezoelectric lithotripter ("piezolith 2300") was used in 24 patients for extracorporeal fragmentation of radiolucent gallbladder stones. in 19 patients with one stone and 4 patients with two stones (diameter: 0.8-3.1 cm) fragmentation to a maximal fragment size of 7 mm was achieved. one to three treatment sessions were necessary (mean 1.5). during adjuvant oral litholytic therapy with chenodeoxycholic acid and ursodeoxycholic acid (500 mg each daily up to 80 kg bodyweight and 750 mg in patien ...	2009	2667262
fifteen years of experience on the use of libexin tablets.	the antitussive libexin was synthesized in the research laboratory of chinoin pharmaceutical and chemical works ltd., budapest. observations of the drug in different disease groups have been surveyed on the basis of data published over more than twenty years. according to the unanimous opinion of the authors the drug does not depress respiration, it rather improves the values of the respiratory function. the majority of the examining physicians are on the opinion that it does not hinder expector ...	2008	2667194
our knowledge of drug interactions with oral contraceptives.	in the introduction the author points out the importance, mechanism and consequence of interactions between oral contraceptives and other drugs. the interactions between certain drugs with different pharmacological action and the contraceptive tablets which decrease or increase the contraceptive effect as well as the drugs whose effect may be influenced by the contraceptive tablets have been discussed. cases in which only a few data refer to, or no clinical proof supports interaction, are also m ...	2009	2667191
hypocholesterolemia in childhood.		2008	2666625
hypocholesterolemia in childhood.		2008	2666625
binding of vibrio cholera toxin and the heat-labile enterotoxin of escherichia coli to gm1, derivatives of gm1, and nonlipid oligosaccharide polyvalent ligands.	vibrio cholera toxin and the heat-labile enterotoxin of escherichia coli have been shown to differ somewhat in their ligand specificity and in the antigenicity of their binding sites. therefore, the components of the oligosaccharide portion of gm1 bound by cholera toxin and the heat-labile enterotoxin of e. coli were identified by determining the concentration of gm1, derivatives of gm1, oligosaccharide isolated from gm1, or clustered oligosaccharide needed to inhibit toxin binding to gm1-coated ...	1989	2666416
[long-term results following breast reconstruction].	a ten-year experience of breast reconstruction (br) at the gustave-roussy institute (paris) provides material for a long-term analysis of carcinologic and cosmetic results. carcinologic results have been studied in a group of 120 breast reconstructions which was matched to a group of 120 mastectomies without br. no statistical difference was observed both for the overall survival and the disease-free survival in both groups. the percentage of local recurrences in the reconstructed breast was inf ...	2004	2666356
prophylactic endoscopic sclerotherapy of oesophageal varices in liver cirrhosis. a multicentre prospective controlled randomised trial in vienna.	the effect of prophylactic treatment of oesophageal varices by endoscopic injection sclerotherapy before the first episode of variceal haemorrhage was studied in patients with cirrhosis in a prospective, randomised and controlled multicentre trial. from february 1984 to march 1987 patients with liver cirrhosis and large varices (stage iii-iv according to paquet) were treated and followed up. the sample comprised 87 patients: 45 in the prophylactic treatment and 42 in the control group. after exc ...	2004	2666282
nsaid-induced gastropathy in the elderly: understanding and avoidance.	nonsteroidal anti-inflammatory drugs (nsaids) are a significant cause of gastric mucosal injury and bleeding, particularly in elderly patients. the mechanism of this injury appears to be, at least in part, a disruption of normal cytoprotective mechanisms by the inhibition of prostaglandin production. acute injury results from the local effect of some drugs and may resolve with time. chronic injury may occur with any nsaid and may often be asymptomatic until a complication occurs. treatment of ei ...	2009	2666269
high-resolution structure of the temperature-sensitive mutant of phage lysozyme, arg 96----his.	the structure of the temperature-sensitive mutant lysozyme of bacteriophage t4 in which arginine 96 is replaced by histidine has been determined crystallographically and refined to a residual of 17.6% at 1.9-a resolution. overall, the three-dimensional structure of the mutant protein is extremely similar to that of wild type. there are local distortions in the mutant structure suggesting that the substituted his 96 residue is under strain. this appears to be one of the major reasons for the decr ...	1989	2665808
high-resolution structure of the temperature-sensitive mutant of phage lysozyme, arg 96----his.	the structure of the temperature-sensitive mutant lysozyme of bacteriophage t4 in which arginine 96 is replaced by histidine has been determined crystallographically and refined to a residual of 17.6% at 1.9-a resolution. overall, the three-dimensional structure of the mutant protein is extremely similar to that of wild type. there are local distortions in the mutant structure suggesting that the substituted his 96 residue is under strain. this appears to be one of the major reasons for the decr ...	1989	2665808
oral cholera vaccines containing b-subunit-killed whole cells and killed whole cells only. ii. field evaluation of cross-protection against other members of the vibrionaceae family.	because of demonstrable cross-reactivity of cellular antigens contained in b subunit-killed whole-cell (bs-wc) and killed whole-cell-only (wc) oral cholera vaccines with antigens of various non-cholera species of the family vibrionaceae (ncv), the protection conferred by the vaccines against diarrhoea associated with ncv was evaluated during a randomized, double-blind field trial in bangladesh. children aged 2-15 years and women aged greater than 15 years (62,285 in number) received three doses ...	1989	2665350
growth factors, oncogenes and anti-oncogenes in cancer.		2009	2665243
[conventional insulin therapy, infusion pumps, injector syringes. different methods of administration].		2009	2665113
long-term outcomes of an arthritis self-management study: effects of reinforcement efforts.	an underlying assumption of self-care interventions is that they are most effective when reinforced. to test this assumption, 8 months after baseline, 589 subjects who had taken a 6-week arthritis self-management course (asmc) were randomized to (1) receive a bi-monthly arthritis newsletter, (2) attend a new 6-week arthritis reinforcement course (arc) or (3) receive no reinforcement. between 8 and 20 months there were no significant differences among the three randomized groups. the results were ...	2009	2665110
alcoholism and other drug dependencies.	the disease of addiction is upon us and it is obvious that the elderly are not immune. there is every reason to believe from early reports that the elderly respond favorably to treatment, perhaps more so than their younger counterparts. it is believed that treating chemical dependency as a primary disease rather than as a symptom of something else has been a great boon in terms of improving recovery rates. furthermore, group therapy is the main component of treatment in rehabilitation, as it aff ...	1989	2664840
introduction to immunocytochemistry.	immunocytochemistry has opened a new era in research and diagnosis. the development of immunocytochemical methods has made it possible to identify in situ normal and pathological tissue constituents, which it has not been possible to detect using ordinary histological methods. however, immunocytochemical techniques involve several pitfalls, which without proper control protocols can easily lead to incorrect findings. when interpreting the results obtained, account must always be taken of the mor ...	2009	2664772
the problem of nasal obstruction.		2008	2664651
the post-antibiotic effect defined by bacterial morphology.	three strains of escherichia coli were incubated with either ciprofloxacin or ampicillin. filamentation of bacteria was observed after 1-2 h. after 5 h of contact with either drug the percentage of filaments exceeded 90%. the organisms were washed and incubated on drug free medium. antibiotics when bound to an enzyme render that enzyme inactive; upon removal of the organisms from the antibiotic, the synthesis of enzymes resumes. the period of time encompassing the inactive enzymatic state of the ...	1989	2663811
is there life after roe v. wade?	mahowald's article is one of three in this issue of the hastings center report under the overall title of "abortion: searching for common ground." the articles were occasioned by the impending u.s. supreme court decision in webster v. reproductive health services (decided 3 jul 1989), which was widely regarded as the court's reconsideration of roe v. wade (1973). the debate in the united states over abortion has become intransigent and polarized since roe, and the hcr articles by mahowald, m. gl ...	2009	2663777
indicator dilution time-activity curves demonstrated by rapid magnetic resonance imaging techniques and paramagnetic contrast agent.	indicator dilution time-activity curves are demonstrated using magnetic resonance imaging (mri) as the detector and a paramagnetic contrast agent as the indicator. manganese chloride was injected into a flow phantom. the nuclear magnetic resonance (mr) intensity was measured downstream. several flow rates were used. the observed mr intensity decreased as the paramagnetic indicator passed through the imaging plane. the qualitative changes of the mr intensity decrease varied in accordance with ind ...	2008	2663765
clinical trial of clonidine hydrochloride as an antisecretory agent in cholera.	clonidine hydrochloride (an alpha 2-adrenoceptor agonist) was tested for antisecretory effects in patients with cholera in a randomized controlled trial. nineteen adults with diarrhea due to vibrio cholerae were treated with clonidine (0.9 mg/24 h orally for 72 h) and 18 served as controls. during the first 24 h of treatment and for 24 h afterwards, the mean +/- sd concentrations of sodium (in millimoles per liter) in the stools of clonidine-treated patients were 120.6 +/- 10.9 and 112.3 +/- 11. ...	1989	2663610
spontaneous intramural perforation of the esophagus: case report and review of the literature.	a 47-year-old male suffered spontaneous intramural perforation of his esophagus following tracheostomy and nasogastric intubation. the reports of this unusual lesion in the literature are reviewed, and the characteristic radiographic and endoscopic features demonstrated.	2009	2663466
serum lipid-bound sialic acid as a tumoral marker in minimal residual tumors.	the lipid-associated sialic acid (lasa) level in serum was increased in 663 out of 794 patients (83.5%) of which 55.1% were cea negative. there were 16.5% lasa (possibly false) negative, cea positive patients. there were 24.1% false positives in 116 patients without malignant tumors. in manifest prostatic carcinoma 94.2% of the lasa values but only 36.5% of the prostatic acid phosphatase values were increased. similarly, in breast and pulmonary carcinoma, lasa was more sensitive than cea. in 499 ...	2009	2663215
[common risk factors in the prognosis of myocardial infarction].		2009	2663156
response of solid tumors to chemotherapy monitored by in vivo 31p nuclear magnetic resonance spectroscopy: a review.	in vivo 31p nuclear magnetic resonance (mr) spectroscopy has shown great promise as a tool for cancer research and the clinical management of solid tumors. it is now possible in some cases to integrate mr spectroscopy with routine mr imaging of the cancer patient, so that tissue identified as tumor on an mr image can be examined biochemically and monitored following treatment. alterations have been observed in the phosphorus mr spectra of patient tumors after treatment, but the causes and conseq ...	2009	2663140
picosecond tryptophan fluorescence of thioredoxin: evidence for discrete species in slow exchange.	the steady-state tryptophan fluorescence and time-resolved tryptophan fluorescence of escherichia coli thioredoxin, calf thymus thioredoxin, and yeast thioredoxin have been studied. in all proteins, the tryptophan residues undergo strong static and dynamic quenching, probably due to charge-transfer interactions with the nearby sulfur atoms of the active cysteines. the use of a high-resolution photon counting instrument, with a time response of 60 ps full width at half-maximum, allowed the detect ...	1989	2663070
exploration of cervico-encephalic vessels using trans-brachial approach on outpatients.	among the several methods used for the exploration of supra-aortic vessels, none is perfect. the intra-arterial digital subtraction angiography is a secure method. the transbrachial approach for this purpose is a safe and efficient technique. the possible risks at the level of humeral artery can be reduced by applying the method described in the text. we present our experience among 200 patients, using mostly the right brachial artery. the quality of image was good in 3/4 of cases. humeral arter ...	2009	2662882
primordial birdheaded nanism associated with progressive ataxia, early onset insulin resistant diabetes, goiter and primary gonadal insufficiency. a new syndrome.	a new syndrome in two siblings with primordial birdheaded nanism, progressive ataxia, goiter, primary gonadal insufficiency and insulin resistant diabetes mellitus is presented. plasma concentrations of tsh, pth, lh, fsh, acth, glucagon and insulin all working through cell membrane receptors were elevated. a generalized cell membrane defect was suggested to be the pathophysiological abnormality in these patients.	2008	2662702
[fluorescent cholesterol derivatives in studies of membranes and lipoproteins].	the pathways of fluorescent chromophores introduction into the cholesterol molecule are reviewed and physicochemical, optical properties and biological identity of fluorescent cholesterol derivatives (fcd) to the natural analogues are briefly characterized. methods of the fcd incorporation into biological objects are discussed. the main part of the review is devoted to the use of fcd to investigate the model and biological membranes, blood plasma lipoproteins and their interactions with cells. t ...	2009	2662546
what lies ahead in infant nutrition.	factors in human milk serve as stimuli for present and future investigation as supplements for infants. these substances involve macronutrients and micronutrients. some substances such as minerals may serve as guidelines for minima and maxima for infant nutrition. while nutritional studies are needed for the prevention of disease, simultaneous nutritional studies for low birth weight and ill infants will bring major alterations in understanding of nutritional needs and types of feedings to becom ...	1989	2662411
[the link between cholesterol and atherosclerosis: intervention trials].	intervention trials aimed at influencing the course of atherosclerosis by reducing blood cholesterol levels of two types: some of them evaluate the clinical consequences of atherosclerosis, while the others study the disease itself by means of arteriography. several trials of the first type have convincingly shown that the incidence of coronary disease decreases after at least 5 years of medicinal treatment. as for direct visualization trials, they seem to indicate that the development of athero ...	2009	2662362
[campylobacter pylori and pathology of the gastro-duodenal mucosa. critical review of clinico-experimental and therapeutic contributions].	over the past five years, a series of important contributions have appeared in the medical literature on the role of infective agents in the pathogenesis of gastric and duodenal inflammation. the analysis of the available data confirms the possible role of campylobacter pylori in causing acute inflammation of the type b antral gastritis, although its role in the pathogenesis of gastric and duodenal ulcer and of the socalled non ulcer dyspepsia is still doubtful. not even the results of therapeut ...	1989	2661960
pelvic and para-aortic lymphadenectomy in cancer of the ovary.	the role of the lymphadenectomy in ovarian carcinoma is widely discussed. the natural history of disease, its tendency to spread to peritoneal cavity and the lack of any reported series of careful node dissections undertaken during surgical exploration has made it difficult to establish the real significance of nodal metastatization and the optimal therapeutic approach for patients with positive nodes. at the istituto nazionale tumori, milan, 341 patients with ovarian carcinoma have been subject ...	2009	2661087
intraoperative staging in ovarian cancer.	in patients with early stage i or ii ovarian cancer a meticulous staging laparotomy is required; this should include omentectomy, pelvic and paraaortic lymphadenectomy, multiple peritoneal biopsies and diaphragmatic biopsies. adjunctive therapy is based on these surgical-pathological findings. in patients with advanced disease (stages iii and iv) it has been demonstrated that optimal tumour reduction enhances the length of survival. a complete resection of all gross disease in the abdominal cavi ...	2009	2661086
the roles of work and of working in disorders of the upper extremity.		2009	2661024
[effect of bacterial toxins on the mitogen-induced increase of the ca2+ concentration in the cytoplasm of rat thymocytes. the role of n proteins].	the effect of bacterial toxins, modifying the activity of regulatory n proteins of adenylate cyclase and probably other systems, on the mitogen-induced changes of cytosolic free ca2+ concentration ([ca2+]i) has been studied using ca2+ fluorescent probe quin-2. it is shown that treatment of thymocytes with cholera toxin, e. coli heat-labile (hl) toxin or pertussis toxin abolishes the concanavalin a (con a)-induced rise of [ca2+]i. the inhibitory effect of cholera and hl toxins can be explained by ...	1989	2660922
expression of il-6 in normal individuals and in patients with autoimmune disease.		2009	2660696
[spontaneous dissection of the cervical internal carotid artery disclosed by migraine attack].		2009	2660657
[prognosis in synchronous liver metastasis from colorectal cancer. a multicenter study of patients with cancer of the rectum and cancer of the rectosigmoid colon].	a prospective investigation of 188 patients with cancer of the rectum and rectosigmoid colon with synchronous liver metastases is described. the mean survival time for 183 patients who did not receive any treatment for the liver metastases was six months and only one survived for longer than 37 months. after extirpation of the primary tumour, the most significant prognostic factors were etrahepatic metastases, enlarged liver on account of metastases and more than three liver metastases. serum ba ...	2009	2660370
cytoskeletal proteins including myofilaments in human tumors.		1989	2660368
[epidemiology and heterogeny].	the innovation of epidemiology plays a crucial role in the development of the health sciences. the authors emphasize the importance of epistemological analysis related to scientific and technical production. they focus on the theoretical and methodological contributions of the principal latin american groups in the field of epidemiology, stating their main accomplishments, issues and potentials. when reviewing those conceptual and practical innovations, the authors analyse the effects of broader ...	2008	2660269
[epidemiology and heterogeny].	the innovation of epidemiology plays a crucial role in the development of the health sciences. the authors emphasize the importance of epistemological analysis related to scientific and technical production. they focus on the theoretical and methodological contributions of the principal latin american groups in the field of epidemiology, stating their main accomplishments, issues and potentials. when reviewing those conceptual and practical innovations, the authors analyse the effects of broader ...	2008	2660269
lack of correlation between congo red binding and enteroinvasiveness in escherichia coli.		1989	2659682
amoxicillin in the treatment of asymptomatic bacteriuria in pregnancy: a single dose of 3 g amoxicillin versus a 4-day course of 3 doses 750 mg amoxicillin.	a prospective, randomized, controlled comparative clinical trial was carried out with the aim of investigating the efficacy and tolerance of two different dosage regimens of amoxicillin in the treatment of asymptomatic bacteriuria during pregnancy. patients in group a received a single dose of 3 g amoxicillin, which was compared to a 4-day course of 3 x 750 mg amoxicillin tablets taken every 8 h (group b). significant bacteriuria (cfu greater than or equal to 10(5)/ml clean catch midstream urine ...	1989	2659442
pancreas transplantation.		2009	2659253
development of nephrology nursing care in europe: 1978-1988.	nephrology nursing care in europe has been accelerated by medical and technical advances. nurses are becoming more and more involved in decision-making processes as opposed to the traditional serving role. this article analyzes some aspects responsible for these changes in europe from 1978-1988 and how nephrology nurses adapted to these developments.	2007	2658872
lumbar cutaneous hemangiomas as indicators of tethered spinal cords.	children with cutaneous hemangiomas in the lumbar region often also have tethered spinal cords. this diagnosis can be overlooked, because children with cutaneous hemangiomas may be otherwise asymptomatic and neurologically normal. from 1983 to 1987, six consecutive children with lumbar cutaneous hemangiomas underwent magnetic resonance imaging, and a seventh had a myelogram. in all seven children, despite their normal neurologic status, tethered spinal cords were diagnosed. all children had oper ...	2009	2657627
a role for hemispheric asymmetry in human behavioral variability.	a model is presented in which functional lateral specialization and selective hemisphere priming combine to provide a mechanism for behavioral variability. the model is tested and supported by two experiments in which lateral attentional priming produces significant reductions in between-subject and within-subject variability. these findings help us to understand the source of behavioral variability, broaden our knowledge of the gross structures and functions of the brain, provide information ab ...	1989	2657608
pro-sequence of subtilisin can guide the refolding of denatured subtilisin in an intermolecular process.	subtilisin e, an alkaline serine protease consisting of a single polypeptide chain of 275 amino acids is produced from a pre-pro-protein. the pre-sequence functions as the signal peptide for protein secretion across the membrane. deletion of the pro-sequence yields mature but inactive subtilisin: the 77-amino acid pro-sequence must precede the mature subtilisin to guide the latter into an active conformation. pro-subtilisin denatured in 6 m guanidine-hcl can be self-processed to the active enzym ...	1989	2657436
new light on the lysenko era.		2009	2657435
how can we pay for graduate medical education in ambulatory care?		2009	2657425
hormonal regulation of phosphoenolpyruvate carboxykinase gene expression is mediated through modulation of an already disrupted chromatin structure.	we used indirect end labeling to identify a series of five hypersensitive (hs) sites in the phosphoenolpyruvate carboxykinase (pepck) gene in h4iie rat hepatoma cells. these sites were found at -4800 base pairs (bp) (site a), at -1300 bp (site b), over a broad domain between -400 and -30 bp (site c), at +4650 bp (site d), and at +6200 bp (site e). sites a to d were detected only in cells capable of expressing the pepck gene, whereas site e was present in all of the cells examined thus far. the h ...	1989	2657389
clinical features and management of amebic liver abscess. experience from 29 patients.	29 patients with amebic liver abscess were evaluated in a study to examine clinical picture, laboratory data, epidemiology, radiologic methods, and therapy. since the clinical picture was unspecific a considerable amount of misdiagnoses occurred, and often originated from pulmonary symptoms. to establish diagnosis one should rely on the triad with positive amebic serology, intrahepatic scanning defects, and clinical picture with fever, right upper quadrant pain, and hepatomegaly. nearly all pati ...	2009	2657204
[evaluation of transrectal longitudinal ultrasonography of chronic non-bacterial prostatitis].	transrectal longitudinal ultrasonography was performed in 34 patients with chronic non-bacterial prostatitis. prostatic stones and cystic lesions were associated with chronic non-bacterial prostatitis in 67.6% and 11.8%, respectively. the annual relapse rates of clinical symptoms were related to the presence of prostatic stones and cystic lesions. transrectal ultrasonography plays a very important role in predicting the clinical courses of chronic non-bacterial prostatitis.	2009	2657157
[clinical features of overseas travellers' infectious enteritis admitted in the hospitals for infectious diseases].		1989	2657133
[survey on overseas traveller's diarrhea at narita airport quarantine station--the species of bacteria isolated and the suspected countries for infection].		1989	2657132
asymmetric dna bending induced by the yeast multifunctional factor tuf.	tuf is a yeast regulatory factor that binds to conserved dna sequence elements involved in gene activation or silencing as well as in telomere function. using gel electrophoresis analyses, we show here that tuf induces dna bending at a site located upstream of the recognition sequence (rpg box). several point mutations in the rpg box reduced tuf binding strength without affecting the extent of bending. selective proteolysis of tuf.dna complexes further suggested the existence of two separate pro ...	1989	2656680
detection of antigens from gram-negative bacilli in urine of children with urinary tract infections. i. common antigen of enterobacteriaceae.	enterobacterial common antigen (eca) has attracted considerable interest since the original publication by kunin in 1962. in the present study we demonstrated this antigen directly in the urine from patients with urinary tract infections (uti) elicited by enterobacteria. sheep erythrocytes were incubated with uti urine; this resulted in their coating with eca, which was studied by means of hemagglutination by anti-eca serum. test tube hemagglutination and the more simple slide hemagglutination w ...	1989	2656534
effects of peptidases on non-adrenergic, non-cholinergic inhibitory responses of tracheal smooth muscle: a comparison with effects on vip- and phi-induced relaxation.	1. the effects of peptidase enzymes on non-adrenergic, non-cholinergic (nanc) inhibitory responses of guinea-pig trachea to electrical field stimulation (efs), and on relaxations induced by vasoactive intestinal peptide (vip) and peptide histidine isoleucine (phi) have been examined. 2. alpha-chymotrypsin reduced both the magnitude and, particularly, the duration of the inhibitory response to efs, whereas papain reduced only the magnitude. aprotinin, a peptidase inhibitor prevented the effects o ...	1989	2655804
1h-nmr studies of synthetic polypeptide models of plasmodium falciparum circumsporozoite protein tandemly repeated sequence.	the major immunodominant region of the coating protein of plasmodium falciparum sporozoites contains multiple tandem copies of the sequence asn-ala-asn-pro (nanp). current efforts for the development of an antisporozoite vaccine are focused on the synthesis of polypeptides reproducing part of the circumsporozoite protein repeat sequence and, in an attempt to relate conformational properties and biological response, 1h-nmr one- and two-dimensional studies of the synthetic models (nanp)2na and (na ...	1989	2655733
control of diarrheal diseases.	the tremendous advances made in the control of diarrheal diseases in the past few years indicate what more can be achieved. even though the lives of an estimated three quarters of a million children are being saved each year, over three million children are still dying from readily preventable diarrheal disease. the challenge is to build on the successes thus far, to learn from experience, to promote changes in health habits that will prevent diarrhea, and to make all of these activities sustain ...	1989	2655632
in situ survival of vibrio cholerae and escherichia coli in a tropical rain forest watershed.	for 12 months, vibrio cholerae and fecal coliform densities were monitored along with nine other water quality parameters at 12 sites in a rain forest watershed in puerto rico. densities of v. cholerae and fecal coliforms were not significantly correlated, even though the highest densities of both bacteria were found at a sewage outfall. high densities of v. cholerae were also found at pristine sites at the highest point in the watershed. the density of escherichia coli and v. cholerae in membra ...	1989	2655536
colony-stimulating factor and drug-induced agranulocytosis.		2008	2655524
colony-stimulating factor and drug-induced agranulocytosis.		2008	2655524
hyperosmolar coma: cellular dehydration and the serum sodium concentration.		2009	2655518
[cardiopathy in noonan syndrome. review of 29 cases].	twenty nine cases, nineteen females and ten males of noonan's syndrome are reported. the age at diagnosis ranged from five months to 11.5 years (median age: 56 months). fifteen cases 57% disclose aspects of the noonan's phenotype in female siblings. fourteen cases showed an associated cardiopathy. the total included eleven pulmonary valve stenosis, five atrial septal defect. three hypertrophic myocardiopathies, three ventricular septal defect, one patients with pulmonary stenosis manifested an a ...	2009	2655512
[relapsing polychondritis. an infrequent cartilage disease].	report of a case affecting a middle-age woman, 48, involving the e.n.t. area only. the aa comment on the features of the disease and report on the good results with medical treatment (prednisolone, indomethacin and dapsone).	2009	2655492
heterogeneity of the exocrine pancreas.	the exocrine pancreas is generally considered to be a homogeneous organ at the morphological and functional levels. recent work, reviewed here, has provided multiple reasons to question this. morphologically, differences have been found in cell size and digestive enzyme content in "peri-" vs. "teleinsular" acini by methods including acinar separation, enzyme assay, and both light and electron microscopic immunocytochemistry. detection of several blood group antigens in human acinar tissue showed ...	1989	2655473
weakness in patients with hemiparesis.	clinical and experimental results are reviewed concerning muscle weakness in patients with hemiparesis after a stroke. the discussion includes the important role that alterations in the physiology of motor units, notably changes in firing rates and muscle fiber atrophy, play in the manifestation of muscle weakness. this role is compared with the lesser role that spasticity (defined as hyperactive stretch reflexes) of the antagonist muscle group appears to play in determining the weakness of agon ...	2009	2655457
a control systems framework for understanding normal and abnormal posture.	this paper presents a brief overview of a control systems framework for understanding normal and abnormal posture, with a special emphasis on postural control during arm movements. the need for meaningful and valid definitions of postural output is discussed. a distinction is drawn between the joint posture and balance outputs of the system. the roles of commands and perturbing inputs in controlling and disturbing joint posture and balance are described. the effects of initial conditions on comm ...	2009	2655455
documentation and appropriateness of prescribing for va ambulatory-care patients.		2009	2655443
platelet function, platelet prostanoids and vascular prostacyclin in diabetes mellitus.		2009	2654960
[the benefits of l-carnitine therapy in essential arterial hypertension with diabetes mellitus type ii].	carnitine is a natural substance essential for the mitochondrial oxidation of long-chain fatty acids and therefore regulates the energy metabolism of the cells. tissue carnitine levels are altered under diabetes mellitus or hypertension. the aim of this study was to evaluate the efficacy and tolerability of l-carnitine therapy in essential hypertension with diabetes mellitus type ii. a clinical trial was performed in two homogeneous groups with essential hypertension and diabetes mellitus type i ...	2009	2654758
[literature storage and retrieval for library users using a microcomputer].		2009	2654664
[a case of immediate fertility restoration following childbirth].	we report an unwanted pregnancy following immediately after fulltime childbirth. we could not find previous reports of this nature in international literature. women who give bottle-feeding are even more liable to early return of ovulatory cycles than women who give breastfeeding. if a puerpera has vaginal bleeding (not lochia), there is an increased risk of ovulation as well as of endometritis. it is no longer acceptable to take impossibility to conceive immediately after delivery for granted: ...	2009	2654662
neuroendocrinology of the normal menstrual cycle.	the physiology of the ovarian/menstrual cycle is dependent on signaling whereby the "ovarian clock" modulates hypothalamic-pituitary function as well as endometrial proliferation and secretion and menses. diagnosis and treatment of infertility are based on these physiologic processes, as is contraceptive intervention. feedback stimulation and inhibition orchestrate fertility.	2008	2654387
randomized clinical trial of daily aspirin therapy in multi-infarct dementia. a pilot study.	seventy multi-infarct dementia patients were randomized into an aspirin-treated group and an untreated control group for an exploratory investigation to determine any effects of 325 mg aspirin daily on cognitive performance. the control group did not receive placebo but evaluations were carried out in a blinded manner. the index group (n = 37, mean age 67.1 years) received 325 mg of aspirin by mouth once daily while the control group (n = 33, mean age 67.6 years) was followed and treated in a si ...	2007	2654259
randomized clinical trial of daily aspirin therapy in multi-infarct dementia. a pilot study.	seventy multi-infarct dementia patients were randomized into an aspirin-treated group and an untreated control group for an exploratory investigation to determine any effects of 325 mg aspirin daily on cognitive performance. the control group did not receive placebo but evaluations were carried out in a blinded manner. the index group (n = 37, mean age 67.1 years) received 325 mg of aspirin by mouth once daily while the control group (n = 33, mean age 67.6 years) was followed and treated in a si ...	2007	2654259
biology of sweat glands and their disorders. ii. disorders of sweat gland function.	part i of this article (j am acad dermatol 1989; 20:537-63) focused on normal sweat gland function. part ii provides a discussion of hyperhidrosis and hypohidrosis. hyperhidrotic disorders affect the palms and soles and the axillae and are associated with previous spinal cord injuries, peripheral neuropathies, brain lesions, intrathoracic neoplasms, systemic illness, and gustatory sweating. hypohidrotic disorders include anhidrotic ectodermal dysplasia, hereditary sensory neuropathy, holmes-adie ...	2006	2654213
home care nursing: integration of politics and nursing.	home care is an important player in the health care arena because of its desirability and potential for cost savings. today, home care nurses are joining physicians, hospitals, and nursing homes at the table in policy discussions with government, business, insurers, and consumers. home care nurses are speaking up and demanding a piece of the health care pie, on behalf of their patients. by virtue of their frontline position in the community, on the street, and in the patient's home, home care nu ...	2009	2654152
chromosomal transfer and in vivo cloning of genes in vibrio cholerae using rp4::mini-mu.	the rp4::mini-mu replicon has been used to transfer chromosomal genes by conjugation and to clone in vivo metabolic, toxin and flagellar genes of vibrio cholerae. rp4::mini-mu was introduced into several strains of v. cholerae and these strains were mated with v. cholerae or escherichia coli k-12 recipients. r'-episomes carrying the respective genes were maintained in reca recipients and were detected by complementation of auxotrophic, nontoxinogenic and aflagellate mutations in v. cholerae.	1989	2653964
campylobacter jejuni chromosomal sequences that hybridize to vibrio cholerae and escherichia coli lt enterotoxin genes.	campylobacter jejuni is one of the main etiologic agents of gastrointestinal illness in developing and developed areas throughout the world. isolation of enterotoxin-producing c. jejuni has been associated with clinical symptoms of a watery-secretory type of diarrhea. although physiological and immunological relatedness has been demonstrated between the c. jejuni enterotoxin (cjt), the vibrio cholerae enterotoxin (ct), and the heat-labile cholera-like escherichia coli enterotoxin (lt), nucleotid ...	1989	2653963
stress in medical undergraduates and house officers.	junior doctors, and to a lesser extent medical students, suffer higher rates of stress and depression than the general population. while some of the causes of these problems may lie with the individual, others are associated with organizational and career factors and with a training which still does not prepare them for those first postgraduate years.	2009	2653534
nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-csf (il-3) expression.	post 5-fluorouracil-treated murine marrow cells were infected with a retroviral vector (mpzen) bearing a multi-potential colony stimulating factor (multi-csf) cdna insert and then transplanted into lethally irradiated syngeneic recipients to study the effects of autocrine production of multi-csf in normal hematopoietic cells. extremely high levels (14,000 u/ml) of multi-csf were detected in the sera and in media conditioned by various hematopoietic tissues of the transplanted animals. while sple ...	2008	2653457
amino acid sequence of a 15 kilodalton actin-binding fragment of turkey gizzard caldesmon: similarity with dystrophin, tropomyosin and the tropomyosin-binding region of troponin t.	we have determined the amino acid sequence of a 15 kda actin-binding fragment of turkey gizzard caldesmon. the 96-residue fragment contains 29 acidic and 29 basic residues, and is predicted to have an extended helical conformation stabilized by numerous internal salt bridges. cad15 bears some resemblance to dystrophin, tropomyosin and several other proteins, but is most strikingly similar to the tropomyosin-binding segment of troponin t.	1989	2653315
the sin of pride: research in obstetrics and gynecology.		2009	2653038
relevance of hepatitis b viral dna in assessment of potential liver allograft recipients.		1989	2652828
overcoming early cyclosporine nephrotoxicity after liver transplantation.		2005	2652724
no association between post-transplant erythrocytosis, thromboembolic events, and cyclosporine therapy.		2009	2652691
treatment of hematogenous pyogenic vertebral osteomyelitis with anterior debridement and primary bone grafting.	from 1971 to 1984 at the university of rochester medical center, 23 adult patients underwent surgical treatment via an anterior approach for pyogenic vertebral osteomyelitis. data from 21 patients with greater than 2-year follow-up is presented in this report. surgical debridement via an anterior approach was performed in all 21 patients. bone grafting with iliac crest or rib strut was done in 19 patients. clinical follow-up averaged 4 years, with a range of 2 years to 9 years, 9 months. no pati ...	2009	2652335
[history of the organization of emergency services in st. petersburg].		2009	2652330
[ear diseases--potentials and limitations of radiology].	the possibilities and limitations of conventional plain x-ray films, angiography, pluridirectional tomography, high-resolving ct (hr-ct) and magnetic resonance tomography (mrt) are described in general and then demonstrated in greater detail on the basis of characteristic findings in otological diseases. hr-ct is definitely superior to pluridirectional tomography within the general framework of diagnostic technique that goes beyond the initial findings. mrt is of only limited diagnostic value de ...	2009	2652270
long-term tamoxifen therapy for breast cancer.		2009	2651287
[myoglobin--its importance and possible methods of determination].		2009	2650888
[dna modification and carcinogenesis--early events caused by a heterocyclic aromatic amine, glu-p-1].	isolation, structure and activity of a mutagen, 2-amino-6-methyldipyrido [1, 2-a: 3', 2'-d] imidazole (glu-p-1), were summarized. the metabolic activation, its specific reaction with dna and biomimetic mutation of proto-ras oncogene were described.	2008	2650626